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Title:
TISSUE DISTRIBUTION, KIMETICS, AND BIOLOGIC HALF-LIFE OF MAGNESIUMIN THE DOG ( AMERICAN JOURNAL OF PHYSIOLOGY, VOL. 204, JUNE 1963, PGS. 1086-1094 ) (PARTIAL)
Subject Terms:
HREX; ANIMALS; MAGNESIUM
Document Location:
Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV
Document Type:
JOURNAL ARTICLE
Publication Date:
1963 Dec 31
Declassification Status:
Never classified
Document Pages:
0009
Accession Number:
NV0702736
Originating Research Org.:
REYNOLDS ELECTRICAL AND ENGINEERING COMPANY
OpenNet Entry Date:
1994 Aug 27
OpenNet Modified Date:
2012 May 14
Description/Abstract:
MAGNESIUM-28 OF A HIGH SPECIFIC ACTIVITY WAS USED IN THESE STUDIES. IT WAS RAPIDLY INJECTED INTRAVENOUSLY INTO 12 DOGS, AND CONCENTRATION- TIME COURSE CURVES IN PLASMA WERE OBTAINED. URINARY AND FECAL EXCRETION WAS FOLLOWED IN SEVEN ANIMALS. THE DOGS WERE KILLED 7 MINUTES TO 68 HOURS FOLLOWING INJECTION. SEVENTY-FOUR TISSUES WERE SAMPLED AND ASSAYED FOR MAGNESIUM-28 CONCENTRATION. PLASMA MAGNESIUM- 24 WAS DETERMINED BY FLAME SPECTROPHOTOMETRY. WITH THESE DATA, IT WAS POSSIBLE TO FOLLOW THE CONCENTRATION-TIME COURSE OF MAGNESIUM-28 IN THE VARIOUS TISSUES AS WELL AS TO CALCULATE THEIR EXCHANGING MAGNESIUM-24 CONTENT AND EFFECTIVE RATES OF CHANGE. A VARIATION IN THE PATTERN OF UPTAKE AND IN CONCENTRATION OF EXCHANGING MAGNESIUM-24 WAS NOTED AMONG THE DIFFERENT TISSUES. THE BIOLOGIC HALF-LIFE OF MAGNESIUM-28 IN THE DOG, ESTIMATED FROM EXCRETION DATA WAS 11 DAYS.


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