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Title:

CONCENTRATION-TIME COURSE IN THE PLASMA OF MAN OF RADIOMERCURY INTRODUCED AS A MERCURIAL DIURETIC ( DEPARTMENT OF MEDICINE, TULANE UNIVERSITY SCHOOL OF MEDICINE, ( CONTINUED IN ABSTRACT )

Author(s):

BURCH, G E; CRONVICH, J A; GORDON, W; MILNOR, J P; OVERMAN, W; RAY, C T; THREEFOOT, S A

Subject Terms:

HREX; MERCURY

Document Location:

Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV

Document Type:

JOURNAL ARTICLE

Publication Date:

1948 Dec 20

Declassification Status:

Never classified

Document Pages:

0010

Accession Number:

NV0702731

Originating Research Org.:

REYNOLDS ELECTRICAL AND ENGINEERING COMPANY

OpenNet Entry Date:

1994 Aug 27

OpenNet Modified Date:

2012 May 14

Description/Abstract:

( CONT'D FROM TITLE ) DECEMBER 20, 1948, PGS. 661-670 ) (PARTIAL) RADIOACTIVE MERCURY AND INJECTED INTRAVENOUSLY HAS BEEN STUDIED IN 15 HUMAN SUBJECTS. ANALYSIS OF THE REGRESSION CURVES DEMONSTRATES THAT THERE ARE AT LEAST THREE MAJOR EXPONENTIAL RATES RESPONSIBLE FOR THE DECLINE IN CONCENTRATION OF MERCURY IN THE PLASMA. THE FIRST RATE IS APPARENTLY DEPENDENT TO A LARGE EXTENT UPON MECHANICAL MIXING; THE SECOND IS POSSIBLY DUE TO RELATIVELY RAPID ADSORPTIVE, CHEMICAL AND DIFFUSION PHENOMENA WITH MIGRATION INTO DYNAMIC AND MORE STABLE COMPARTMENTS; THE THIRD RATE IS MOST PROBABLY A REFLECTION MAINLY OF EXCRETORY PROCESSES, PRINCIPALLY URINARY. IT WAS NOT POSSIBLE FROM THESE DATA TO DRAW ANY CONCLUSIONS AS TO DIFFERENCES BECAUSE OF THE VARIOUS CLINICAL STATES IN THE SUBJECTS STUDIED.

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