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Title:
GRANULOCYTOPOIESIS AND EFFECTS OF IRRADIATION ( REPRINT FROM THE PROCEEDINGS OF THE IX CONGRESS OF THE INTERNATIONAL SOCIETY OF HEMATOLOGY VOL III ) (PARTIAL)
Author(s):
MALONEY, M A [ARGONNE NATIONAL LABORATORY]; PATT, H M [ARGONNE NATIONAL LABORATORY]
Subject Terms:
HREX
Document Location:
Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV
Document Type:
JOURNAL ARTICLE
Publication Date:
Declassification Status:
Never classified
Document Pages:
0004
Accession Number:
NV0702381
OpenNet Entry Date:
1994 Aug 27
OpenNet Modified Date:
2017 Dec 21
Description/Abstract:
THIS PAPER FOCUSES ON EXAMINING THE DEVELOPMENT OF RADIATION-INDUCED GRANULOCYTOPENIA IN SEVERAL SPECIES IN THE LIGHT OF PRESENT UNDERSTANDING OF GRANULOCYTE KINETICS. THE ENTIRE SEQUENCE AFTER MODERATE RADIATION DOSES TO THE TOTAL BODY REFLECTS MAINLY A FAILURE OF REPLACEMENT OF THE EARLY BONE MARROW CELLS THAT ARE KILLED, AND OF THE LATE BONE MARROW CELLS WHOSE DEVELOPMENT AND RATE OF RELEASE ARE UNCHANGED. RECOVERY FROM RADIATION INJURY IS IN SOME RESPECTS A NEBULOUS CONCEPT. THE VAST EXPERIENCE WITH MARROW TRANSPLANTATION AFTER IRRADIATION INDICATES THAT COMPARATIVELY FEW INTACT CELLS CAN GREATLY INFLUENCE RECOVERY. SMALL DIFFERENCES IN THE NUMBER OF SO- CALLED STEM CELLS IN THE VARIOUS SPECIES MIGHT ACCOUNT FOR DIFFERENCES IN RECOVERY, EVEN IF THE OVERALL KINETIC PATTERNS ARE SIMILAR.


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