PURL
(876 K)
Title:
CONTROL OF GRANULOCYTE FORMATION ( BROOKHAVEN SYMPOSIUM ON HOMEOSTATIC MECHANISMS JUNE 12-14, 1957 )
Document Location:
Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV
Document Type:
JOURNAL ARTICLE
Declassification Status:
Never classified
Accession Number:
NV0702379
OpenNet Entry Date:
1994 Aug 27
OpenNet Modified Date:
2017 Dec 15
Description/Abstract:
POSSIBLE MECHANISMS FOR PHYSIOLOGIC CONTROL OF GRANULOCYTE FORMATION HAVE BEEN CONSIDERED AGAINST THE BACKGROUND OF THE GRANULOCYTE LIFE CYCLE. SEVERAL LINES OF EVIDENCE SUGGEST THAT THE DETECTABLE CIRCULATING GRANULOCYTES ARE IN DYNAMIC EQUILIBRIUM WITH LARGE MEDULLARY AND EXTRA-MEDULLARY POOLS. AUTONOMOUS CONTROL OF GRANULOCYTE FORMATION IS VISUALIZED AS A SEQUENCE OF LOCAL EVENTS REVOLVING AROUND THE NUMBER OF CELLS IN THE VARIOUS FOCI OF GROWTH IN MARROW. THIS SEQUENCE BEGINS WITH THE RELEASE OF CELLS FROM MARROW WHICH IS BELIEVED TO BE A FUNCTION MAINLY OF THE RATE OF BLOOD FLOW THROUGH THE MARROW AND THE GRANULOCYTE GRADIENT. IT IS SUGGESTED THAT THE NUMBER OF MARGINAL CELLS MAY BE AN IMPORTANT DETERMINANT OF THE RATE OF ENTRY FROM MARROW TO BLOOD.