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Title:
GIANT FOLLICULAR LYMPHOBLASTOMA: ITS TREATMENT WITH RADIOISOTOPES ( ANNALS OF INTERNAL MEDICINE VOL. 49 NO. 1 JULY 1958 )
Author(s):
DONALD, W G [UNIVERSITY OF CALIFORNIA, BERKELEY]; LAWRENCE, J H [DONNER LABORATORIES]
Subject Terms:
HREX
Document Location:
Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV
Document Type:
JOURNAL ARTICLE
Publication Date:
1958 Jul 01
Declassification Status:
Never classified
Document Pages:
0016
Accession Number:
NV0702378
OpenNet Entry Date:
1994 Aug 27
OpenNet Modified Date:
2017 Dec 22
Description/Abstract:
THE CLINICAL AND PATHOLOGIC FINDINGS IN 20 PATIENTS WITH GIANT FOLLICULAR LYMPHOBLASTOMA ARE PRESENTED AND DISCUSSED. THE CLINICAL FINDINGS CORRESPOND WELL TO THOSE PREVIOUSLY REPORTED IN THE LITERATURE. THERE IS A MARKED LACK OF CORRELATION, IN THIS SERIES, BETWEEN THE DURATION OF THE DISEASE AND THE RELATIVE BENIGN OR MALIGNANT APPEARANCE OF THE LESIONS HISTOLOGICALLY. SIXTEEN PATIENTS WHO RECEIVED RADIOACTIVE PHOSPHORUS ARE PRESENTED. FIVE PATIENTS RECEIVED THIS THERAPY WHILE IN THE TERMINAL STAGE OF THEIR ILLNESS. ELEVEN PATIENTS RECEIVED ADEQUATE 32-P THERAPY. THREE PATIENTS SHOWED EXCELLENT RESPONSES, ONE SHOWING COMPLETE AND TWO NEARLY COMPLETE REMISSION. THREE PATIENTS HAD GOOD RESPONSES, WITH DURATION OF CONTROL FROM SEVEN TO 20 MONTHS. THREE PATIENTS HAD FAIR RESPONSE BUT REQUIRED ADDITIONAL LOCAL X-RAY THERAPY FOR CONTROL. THE AVERAGE DURATION OF THE DISEASE IN THE 10 ADEQUATELY TREATED CASES FOLLOWED TO TERMINATION WAS 6.7 YEARS. RADIOACTIVE PHOSPHORUS WITH LOCAL X-RAY, OR ALONE, MAY BE THE TREATMENT OF CHOICE IN GIANT FOLLICULAR LYMPHOBLASTOMA AND CERTAINLY MERITS SERIOUS CONSIDERATION, PARTICULARLY IN THOSE CASES WITH WIDESPREAD INVOLVEMENT.