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Title:
PRACTICAL ASPECTS OF RADIOACTIVE ISOTOPES IN RELATION TO MEDICAL TREATMENT ( REPRINTED FROM THE BRITISH MEDICAL JOURNAL, VOL. 11, PAGE 747 )
Author(s):
MITCHELL, J S [UNIVERSITY OF CAMBRIDGE, VETERINARY SCHOOL OF MEDICINE]
Subject Terms:
HREX
Document Location:
Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV
Document Type:
JOURNAL ARTICLE
Publication Date:
1951 Dec 31
Declassification Status:
Never classified
Document Pages:
0016
Accession Number:
NV0702364
OpenNet Entry Date:
1994 Aug 27
OpenNet Modified Date:
2017 Dec 21
Description/Abstract:
THE USE OF ARTIFICIAL RADIOACTIVE ISOTOPES IN THE APPLICATION OF MEDICAL TREATMENT IS DISCUSSED. RADIO-SODIUM HAS RECEIVED LIMITED PRACTICAL APPLICATION TO PRODUCE EFFECTS COMPARABLE TO TOTAL BODY GAMMA RADIATION IN THE TREATMENT OF CHRONIC MYELOID AND LYMPHATIC LEUKAEMIA AND POLYCYTHEMIA. NO PROMISING RESULTS HAVE BEEN OBTAINED BY THE ATTEMPTED USE IN THE TREATMENT OF OSTEOGENIC SARCOMA OF THE WEAKLY RADIOACTIVE CALCIUM ISOTOPE 45-CA AND THE RADIO-STRONTIUM 89- SR. THE ADVANTAGES OF RADIO-PHOSPHORUS THERAPY IN POLYCYTHEMIA VERA ARE: THE RELIABLE PRODUCTION OF REMISSION, THE REDUCED INCIDENCE OF THROMBOSES AND HEMORRHAGES, THE ABSENCE OF IMMEDIATE OBVIOUS TOXIC REACTIONS, AND THE EASE OF ADMINISTRATION OF THE TREATMENT. THE DISADVANTAGE OF USING RADIO-PHOSPHORUS, OR ANY OTHER RADIOACTIVE ISOTOPE THERAPY IS THAT IT IS IMPOSSIBLE TO REVERSE THE EFFECTS AFTER ITS INTERNAL ADMINISTRATION, AND ONE CANNOT DETECT BEFORE-HAND THE UNUSUALLY RADIO-SENSITIVE PATIENT.