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Title:
EXPERIMENTAL RADIOTHERAPEUTICS ( REPRINT FROM " SCHWEIZERISCHE MEDIZINISCHE WOCHENSCHRIFT " 76TH YEAR, 1946, NO. 37/38, PAGE 883 )
Author(s):
MITCHELL, J S [UNIVERSITY OF CAMBRIDGE, VETERINARY SCHOOL OF MEDICINE]
Subject Terms:
HREX
Document Location:
Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV
Document Type:
JOURNAL ARTICLE
Publication Date:
1946 Dec 31
Declassification Status:
Never classified
Document Pages:
0012
Accession Number:
NV0702362
OpenNet Entry Date:
1994 Aug 27
OpenNet Modified Date:
2017 Dec 21
Description/Abstract:
THIS PAPER DISCUSSES THE RECENT ADVANCES IN RESEARCH IN RADIOTHERAPEUTICS DUE TO THE INFLUENCE OF CYTOLOGY AND CYTO-CHEMISTRY, GENETICS, RADIO-ACTIVE TRACER METHODS AND NUCLEAR PHYSICS. FOR INHIBITION OF MITOSIS, THE POINT OF MAXIMUM RADIO-SENSITIVITY IS USUALLY CONSIDERED TO BE DURING THE PROPHASE STAGE OF BUILDING-UP OF THE CHROMOSOME STRUCTURE. CELLS CAUGHT BY RADIATION IN PROPHASE ARE TEMPORARILY FROZEN. SOME OF THESE CELLS RETURN TO THE RESTING STAGE WITH THE CHROMOSOME NUMBER DOUBLED. WITH THE VERY SMALLEST DOSES, RECOVERY MAY APPEAR TO BE COMPLETE, SO THAT THERE MAY BE A SLIGHT TRANSIENT INCREASE IN THE PERCENTAGE OF CELLS IN MITOSIS AFTER THE TEMPORARY INHIBITION. WITH INCREASING DOSES OBVIOUS RECOVERY IS PROGRESSIVELY LESS COMPLETE. INCLUDED IN THIS DISCUSSION ARE THE FOLLOWING: (1) THE SIGNIFICANCE OF CHROMOSOME BREAKAGE. (2) THE DEPENDENCE OF THE BIOLOGICAL EFFICIENCY OF DIFFERENT RADIATIONS UPON SPECIFIC IONIZATION. (3) THE PRODUCTION OF ARTIFICIAL GAMMA RAY SOURCES FOR USE IN RADIOTHERAPY BY MEANS OF THE PILE. (4) THE THERAPEUTIC POSSIBILITIES OF 32-P, 131-I, AND OTHER RADIOACTIVE ISOTOPES.