Document Details

(666 K)

RADIOACTIVE IODINE IN THE STUDY OF THYROID PHYSIOLOGY - VII. THE USE OF RADIOACTIVE IODINE THERAPY IN HYPERTHYROIDISM

HERTZ, S; ROBERTS, A

HREX

Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV

JOURNAL ARTICLE

1946 May 11

Never classified

0009

NV0702332

1994 Aug 27

2017 Dec 21

ON THE BASIS OF A SERIES OF ANIMAL AND CLINICAL EXPERIMENTS USING RADIOACTIVE ISOTOPES OF IODINE AS A TRACER I THE STUDY OF THYROID PHYSIOLOGY AND IODINE METABOLISM, THE TREATMENT OF 29 CASES OF HYPERTHYROIDISM WITH INTERNAL IRRADIATION BY RADIOACTIVE IODINE WAS INSTITUTED. BY CAREFUL EXCRETION STUDIES, EXTERNAL COUNTER MEASUREMENTS OVER THE THYROID GLAND AND BY PLANNED OPERATIONS IN 2 CASES, DATA WERE OBTAINED WHICH ALLOWED THE CONSTRUCTION OF A FORMULA FOR A PROCEDURE IN TREATMENT. THE ADDITION OF ORDINARY IODINE THERAPY AFTER THE ADMINISTRATION OF RADIO-IODINE OFFERS MANY ADVANTAGES IN THE CLINICAL CARE OF THESE PATIENTS AND IN THE ECONOMY AND SAFETY OF THE PROCEDURE. BY AN ANALYSIS, OVER A LONG PERIOD, OF BOTH THE FAILURES AND SUCCESSES IN THIS SERIES OF 29 CASES, IT IS SHOWN THAT RADIOACTIVE IODINE, WHEN GIVEN IN THE DOSAGE RANGE OF 5 GO 25 MILLICURIES TO UNIODINIZED PATIENTS WITH HYPERTHYROIDISM POSSESSING GOITERS OF 60 TO 75 GM., IS HIGHLY EFFECTIVE AS A CURE OF THE DISEASE IN ABOUT 80 PERCENT OF CASES. WHEN APPRECIABLE ACTIVITY HAS BEEN ADMINISTERED AND SUBTOTAL THYROIDECTOMY IS RESORTED TO, MYXEDEMA OR HYPOMETABOLISM MAY BE EXPECTED TO DEVELOP IN A LARGE FRACTION OF THE CASES (100 PERCENT IN 5 CASES IN THIS SERIES).