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Title:
THE EFFECT OF ERYTHROPOEITIC STIMULATION ON MARROW DISTRIBUTION IN MAN, RABBIT AND RAT AS SHOWN BY FE-59 AND FE-52 ( BLOOD, VOL 24, NO. 4, OCTOBER 1964 ) ( PARTIAL DOCUMENT ) ( IRON-59, IRON-52 )
Author(s):
ANGER, H [DONNER LABORATORIES]; POLLYCOVE, M [DONNER LABORATORIES]; VANDYKE, D [DONNER LABORATORIES]
Subject Terms:
HREX; ANIMALS; BONE MARROW; HUMANS; IRON 52; IRON 59
Document Location:
Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV
Document Type:
JOURNAL ARTICLE
Publication Date:
1964 Oct 31
Declassification Status:
Never classified
Document Pages:
0017
Accession Number:
NV0702312
OpenNet Entry Date:
1994 Aug 27
OpenNet Modified Date:
2017 Dec 21
Description/Abstract:
THE EFFECT OF ERYTHROPOIETIC STIMULATION ON MARROW DISTRIBUTION IN MAN, RABBIT AND RAT AS SHOWN BY 59FE AND 52FE IS DISCUSSED IN THIS REPORT. INFORMATION ON THE DISTRIBUTION OF MARROW IN THE SKELETON OF HUMAN SUBJECTS IS ROUTINELY OBTAINED AT DONNER LABORATORY BY SCANNING WITH A 10-CHANNEL WHOLE-BODY SCANNER 24 HOURS AFTER ADMINISTRATION OF 59FE. THE DOSE IS USUALLY 40 UC., WHICH IS GIVEN IN CONNECTION WITH DIAGNOSTIC FERROKINETIC STUDIES. THE 52FE IS PRODUCED BY ALPHA BOMBARDMENT OF NATURAL CHROMIUM IN THE LAWRENCE RADIATION LABORATORY 88-INCH CYCLOTRON. THE RADIOACTIVE IRON IS SEPARATED FROM THE CHROMIUM BY ETHER EXTRACTION. THE HALF-LIFE OF 52FE IS 8.2 HOURS. THE RESULTS OF WHOLE BODY SCANS OF THE DISTRIBUTION OF 59FE AT THE TIME OF MAXIMUM MARROW INCORPORATION ARE GIVEN FOR ONE NORMAL HUMAN BEING, ONE SEVERE CHRONIC BLEEDER, AND ONE WITH ACUTE HEMOLYTIC ANEMIA. IN THE NORMAL SUBJECT, THE IRON IS CONCENTRATED IN A CROSS-SHAPED AREA CORRESPONDING TO SPINE AND SHOULDER, IN A DIFFUSE THORACIC AREA CORRESPONDING TO THE RIBS, AND IN A RECTANGULAR AREA CORRESPONDING TO THE PELVIS. RADIOIRON DISTRIBUTION FOR THE PATIENT WITH SEVERE BLEEDING OF MANY YEARS' DURATION IS CONCENTRATED IN THE LOWER LIMBS, PARTICULARLY THE KNEE. THE DISTRIBUTION OF RADIOIRON IN THE PATIENT WITH SUBACUTE SEVER HEMOLYTIC ANEMIA OF 1-2 MONTHS' DURATION AND ERYTHROPOIESIS, INCREASED TO 13 TIMES NORMAL AND IS THE SAME AS THAT OF THE NORMAL CONTROL, EXCEPT THERE IS LESS RADIOIRON IN THE LUMBAR SPINE.