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THE TREATMENT OF RADIATION SICKNESS WITH ADRENAL CORTICAL HORMONE ( DESOXYCORTICOSTERONE ACETATE ) ( THE AMERICAN JOURNAL OF ROENTGENOLOGY AND RADIUM THERAPY, VOL LXI, NO 3, MARCH 1949 ) ( PARTIAL )

ELLINGER, F; GLASSER, S M; ROSWIT, B

HREX

Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV

JOURNAL ARTICLE

1949 Mar 31

Never classified

0011

NV0702308

1994 Aug 27

2017 Dec 21

THE PURPOSE OF THIS REPORT IS TO DETERMINE THE EFFECTS OF USING DESOXYCORTICOSTERONE ACETATE (DCA) AS A TREATMENT FOR RADIATION SICKNESS. FIFTY PATIENTS, WHO HAD BEEN IRRADIATED FOR A VARIETY OF BENIGN AND MALIGNANT CONDITIONS, COMPRISED THE GROUP FOR THIS STUDY. ALL OF THE PATIENTS EXHIBITED GASTROINTESTINAL MANIFESTATIONS, IN ADDITION TO OTHER SYMPTOMS OF RADIATION SICKNESS. THE AMOUNT OF RADIATION PRODUCING THESE SYMPTOMS RAGED FROM A SINGLE DOSE OF 50 R TO A TOTAL CUMULATIVE DOSE OF 7,500 R. THE RESULTS OF TREATING THE PATIENTS WITH DCA REVEAL THAT ONLY 3 PATIENTS OUT OF 50 FAILED TO RESPOND TO THIS HORMONE. TWO OF THE 3 FAILURES WERE PATIENTS SUFFERING FROM INOPERABLE ADVANCED BRAIN TUMORS. OF THE REMAINING 47 PATIENTS, 37 WERE COMPLETELY RELIEVED OF THE MOST DISTRESSING SYMPTOMS, NAUSEA AND/OR VOMITING. NINETEEN CASES WERE RELIEVED OF ALL SYMPTOMS INCLUDING NAUSEA AND/OR VOMITING. IN 12 CASES, WHERE NAUSEA AND/OR VOMITING RECURRED DURING THE COURSE OF IRRADIATION, REPEATED ADMINISTRATION OF DCA WAS EFFECTIVE IN RELIEVING THESE SYMPTOMS. HOWEVER, IF THE COURSE OF THE DISEASE FOR WHICH THE PATIENT WAS IRRADIATED SHOWED A RETROGRESSIVE TREND, THEN REPEATED ADMINISTRATION OF DCA WAS LESS EFFECTIVE.