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Title:
FAST NEUTRON RADIOTHERAPY FOR LOCALLY ADVANCED PROSTATE CANCER ( AM J CLIN ONCOL (CCT) 16(2) )
Author(s):
DAVIS, L W [ALBERT EINSTEIN MEDICAL CENTER, PHILADELPHIA, PA]; GRIFFIN, T W [UNIVERSITY OF WASHINGTON, SEATTLE]; HENDRICKSON, F R [FERMI NATIONAL ACCELERATOR LABORATORY, BATAVIA, IL]; KRALL, J M [AMERICAN COLLEGE OF RADIOLOGY]; LARAMORE, G E [UNIVERSITY OF WASHINGTON, SEATTLE]; MAOR, M H; MARTZ, K L; RUSSELL, K J [UNIVERSITY OF WASHINGTON, SEATTLE]; THOMAS, F J
Subject Terms:
HREX; NEUTRON THERAPY STUDY
Document Location:
Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV
Document Type:
JOURNAL ARTICLE
Publication Date:
1993 Dec 31
Declassification Status:
Never classified
Document Pages:
0004
Accession Number:
NV0702225
OpenNet Entry Date:
1994 Aug 27
OpenNet Modified Date:
2017 Dec 21
Description/Abstract:
BETWEEN JUNE 1977 AND APRIL 1983 THE RADIATION THERAPY ONCOLOGY GROUP (RTOG) SPONSORED A PHASE III RANDOMIZED TRIAL INVESTIGATING THE USE OF FAST NEUTRON RADIOTHERAPY FOR PATIENTS WITH LOCALLY ADVANCED (STAGES C AND D(1)) ADENOCARCINOMA OF THE PROSTATE GLAND. PATIENTS WERE RANDOMIZED TO RECEIVE EITHER CONVENTIONAL PHOTON RADIATION OR FAST NEUTRON RADIATION USED IN A MIXED-BEAM (NEUTRON/PHOTON) TREATMENT SCHEDULE. A TOTAL OF 91 ANALYZABLE PATIENTS WERE ENTERED INTO THE STUDY, AND THE TWO PATIENT GROUPS WERE BALANCED WITH RESPECT TO THE MAJOR PROGNOSTIC VARIABLES. ACTUARIAL CURVES ARE PRESENTED FOR LOCAL/REGIONAL CONTROL AND "OVERALL" SURVIVAL. TEN-YEAR RESULTS FOR CLINICALLY ASSESSED LOCAL CONTROL ARE 70 PERCENT FOR THE MIXED-BEAM GROUP VERSUS 58 PERCENT FOR THE PHOTON GROUP (P = 0.03) AND FOR SURVIVAL ARE 46 PERCENT FOR THE MIXED-BEAM GROUP VERSUS 29 PERCENT FOR THE PHOTON GROUP(P= 0.04). THIS STUDY SUGGESTS THAT A REGIONAL METHOD OF TREATMENT CAN INFLUENCE BOTH LOCAL TUMOR CONTROL AND SURVIVAL IN PATIENTS WITH LOCALLY ADVANCED ADENOCARCINOMA OF THE PROSTATE GLAND.