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Title:
FAST NEUTRON THERAPY FOR MALIGANT ASTROCYTOMAS ( JOURNAL OF NEURO-ONOCOLOGY 4 )
Subject Terms:
HREX; NEUTRON THERAPY STUDY
Document Location:
Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV
Document Type:
JOURNAL ARTICLE
Publication Date:
1986 Dec 31
Declassification Status:
Never classified
Document Pages:
0006
Accession Number:
NV0702220
OpenNet Entry Date:
1994 Aug 27
OpenNet Modified Date:
2017 Dec 21
Description/Abstract:
THE TREATMENT OF SUPRATENTORIAL MALIGNANT GLIOMAS HAS CONTINUED TO BE A MAJOR PROBLEM FOR NEUROSURGEONS AND ONCOLOGISTS. POST-OPERATIVE CONVENTIONAL RADIOTHERAPY IS KNOWN TO PROLONG SURVIVAL AND TO ENHANCE THE QUALITY OF LIFE. LOCAL PERSISTENCE OF TUMOR KILLS THE MAJORITY OF PATIENTS. FAST NEUTRON IRRADIATION IS BEING UTILIZED TO TREAT MALIGNANT GLIOMAS BASED ON ITS REPUTED RADIOBIOLOGICAL ADVANTAGES FOR TREATMENT OF LARGE TUMORS AND THE ENCOURAGING PRELIMINARY REPORTS SHOWING TUMOR ERADICATION IN POST-RADIATION BIOPSY AND AUTOPSY SPECIMENS. THIS PAPER REVIEWS THE RESULTS OF FAST NEUTRON IRRADIATION ALONE AND IN COMBINATION WITH PHOTONS AND HYPOXIC CELL SENSITIZERS. SURVIVAL COMPARISONS DO NOT SHOW ANY SUPERIORITY FOR NEUTRONS COMPARED TO CONVENTIONAL RADIATION. HOWEVER, POST-NEUTRON RADIATION TISSUE SAMPLES HAVE SHOWN LESS AGGRESSIVE AND MINIMAL RESIDUAL TUMOR IN MANY INSTANCES. AT THE SAME TIME RADIATION NECROSIS HAS EMERGED AS A SIGNIFICANT PROBLEM. IN SUMMARY, EVEN THOUGH NEUTRON IRRADIATION CAN ERADICATE MALIGNANT GLIOMAS A THERAPEUTIC WINDOW HAS YET TO BE IDENTIFIED.


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