Document Details
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Title:
FAST NEUTRON RADIATION THERAPY FOR GLIOBLASTOMA MULTIFORME ( AMERICAN JOURNAL OF CLINICAL ONCOLOGY )
Author(s):
ANTUNEZ, A [RADIATION THERAPY ONCOLOGY GROUP - PHILADELPHIA, PENNA.]; DAVIS, R [RADIATION THERAPY ONCOLOGY GROUP - PHILADELPHIA, PENNA.]; GRIFFIN, T W [RADIATION THERAPY ONCOLOGY GROUP - PHILADELPHIA, PENNA.]; HENDRICKSON, F [RADIATION THERAPY ONCOLOGY GROUP - PHILADELPHIA, PENNA.]; HUSSEY, D [RADIATION THERAPY ONCOLOGY GROUP - PHILADELPHIA, PENNA.]; LARAMORE, G [RADIATION THERAPY ONCOLOGY GROUP - PHILADELPHIA, PENNA.]; NELSON, J [RADIATION THERAPY ONCOLOGY GROUP - PHILADELPHIA, PENNA.]
Subject Terms:
HREX; NEUTRON THERAPY STUDY
Document Location:
Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV
Document Type:
JOURNAL ARTICLE
Publication Date:
1983 Dec 31
Declassification Status:
Never classified
Document Pages:
0007
Accession Number:
NV0702219
OpenNet Entry Date:
1994 Aug 27
OpenNet Modified Date:
2017 Dec 21
Description/Abstract:
BETWEEN JANUARY 1977 AND SEPTEMBER 1980, 166 PATIENTS WERE ENTERED ON A RTOG PROTOCOL COMPARING NEUTRON-BOOST RADIOTHERAPY WITH STANDARD TREATMENT FOR PATIENTS WITH GLIOBLASTOMAS. EIGHTY-THREE PATIENTS WERE RANDOMIZED TO RECEIVE A NEUTRON BOOST AND 83 TO RECEIVE A PHOTON BOOST AFTER 50 GY PHOTON, WHOLE-BRAIN IRRADIATION. OF THESE, SIX WERE INELIGIBLE AND TWO WERE CANCELED, LEAVING 158 PATIENTS AVAILABLE FOR ANALYSIS. THE MEDIAN SURVIVAL FOR THE NEUTRON-BOOST GROUP WAS 9.8 MONTHS, COMPARED TO 8.6 MONTHS FOR THE PHOTON-BOOST GROUP. THE DIFFERENCE IS NOT STATISTICALLY SIGNIFICANT. AUTOPSIES REVEALED ACTIVELY GROWING PERSISTENT TUMOR IN ALL PHOTON-TREATED PATIENTS COMPARED TO NO EVIDENCE OF ACTIVELY GROWING TUMOR IN THE MAJORITY OF NEUTRON-TREATED PATIENTS.