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Title:
MIXED NEUTRON/PHOTON IRRADIATION OF UNRESECTABLE SQUAMOUS CELL CARCINOMAS OF THE HEAD AND NECK: THE FINAL REPORT OF A RANDOMIZED COOPERATIVE TRIAL ( RADIATION BIOL. PHYS. VOL.17 )
Author(s):
DAVIS, L W [MONTEFIORE HOSPITAL]; GRIFFIN, T W [UNIVERSITY OF WASHINGTON, SEATTLE]; HENDRICKSON, F R [ST. LUKES HOSPITAL]; LARAMORE, G E [UNIVERSITY OF WASHINGTON, SEATTLE]; MAOR, M H; PAJAK, T F [RADIATION THERAPY ONCOLOGY GROUP - PHILADELPHIA, PENNA.]; PARKER, R G [UNIVERSITY OF CALIFORNIA]; THOMAS, F J [CLEVELAND CLINIC, CLEVELAND, OH]
Subject Terms:
HREX; NEUTRON THERAPY STUDY
Document Location:
Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV
Document Type:
JOURNAL ARTICLE
Publication Date:
Declassification Status:
Never classified
Document Pages:
0007
Accession Number:
NV0702218
OpenNet Entry Date:
1994 Aug 27
OpenNet Modified Date:
2017 Dec 21
Description/Abstract:
THREE HUNDRED AND TWENTY-SEVEN PATIENTS WITH INOPERABLE SQUAMOUS CELL CARCINOMAS OF THE HEAD AND NECK WERE ENTERED ON A RANDOMIZED STUDY COMPARING A MIXTURE OF NEUTRON AND PHOTON ("MIXED BEAM") RADIATION THERAPY WITH PHOTON/ELECTRON RADIATION THERAPY. NEUTRON TREATMENT WAS DELIVERED WITH FIXED-BEAM, PHYSICS-LABORATORY-BASED EQUIPMENT. PATIENTS WITH HISTOLOGICALLY PROVEN TUMORS OF T-STATE T(2), T(3), OR T(4) AND ANY N-STAGE WERE ELIGIBLE FOR RANDOMIZATION. PRIMARY TUMOR SITES WERE LIMITED TO CANCERS ORIGINATING IN THE ORAL CAVITY, OROPHARYNX, SUPRAGLOTTIC LARYNX, OR HYPOPHARYNX. PATIENTS ENTERED ON THIS STUDY NOW HAVE A MINIMUM AT-RISK FOLLOW-UP PERIOD OF 6 YEARS. STUDY RESULTS REVEAL NO SIGNIFICANT DIFFERENCES IN OVERALL LOCO- REGIONAL TUMOR CONTROL RATES OR SURVIVAL. SUBGROUP ANALYSIS REVEALS SIGNIFICANT DIFFERENCES BASED ON WHETHER OR NOT PATIENTS PRESENTED WITH POSITIVE LYMPH NODES. LOCO-REGIONAL TUMOR CONTROL RATES FOR PATIENTS PRESENTING WITH POSITIVE LYMPH NODES WERE 30 PERCENT FOR MIXED-BEAM-TREATED PATIENTS VERSUS 18 PERCENT FOR PHOTON-TREATED PATIENTS ( P = 0.05). LOCO-REGIONAL TUMOR CONTROL RATES FOR PATIENTS PRESENTING WITHOUT POSITIVE LYMPH NODES WERE 64 PERCENT FOR PHOTON- TREATED PATIENTS AND 33 PERCENT FOR MIXED-BEAM-TREATED PATIENTS (P = 0.004). CONTROL OF TUMOR LOCATED IN THE NODAL SITES FAVORED MIXED BEAM OVER PHOTONS BY A MARGIN OF 45 PERCENT (49/109) TO 26 PERCENT (23/87) WITH A SIGNIFICANCE OF P = 0.004. POSSIBLE EXPLANATIONS FOR THESE FINDINGS ARE DISCUSSED.