Document Details
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Title:
FAST NEUTRON RADIATION THERAPY FOR UNRESECTABLE SQUAMOUS CELL CARCINOMAS OF THE HEAD AND NECK: THE RESULTS OF A RANDOMIZED RTOG STUDY ( RADIATION ONOCOLOGY BIOL. PHYS. VOL.10 )
Author(s):
DAVIS, R; GRIFFIN, T W [UNIVERSITY OF WASHINGTON, SEATTLE]; HENDRICKSON, F R [ST. LUKES HOSPITAL]; LARAMORE, G E [UNIVERSITY OF WASHINGTON, SEATTLE]; MAOR, M H
Subject Terms:
HREX; NEUTRON THERAPY STUDY
Document Location:
Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV
Document Type:
JOURNAL ARTICLE
Publication Date:
Declassification Status:
Never classified
Document Pages:
0003
Accession Number:
NV0702217
OpenNet Entry Date:
1994 Aug 27
OpenNet Modified Date:
2017 Dec 21
Description/Abstract:
FORTY PATIENTS WITH ADVANCED, UNRESECTABLE SQUAMOUS CELL CARCINOMAS OF THE HEAD AND NECK WERE ENTERED ON A PROSPECTIVE, RANDOMIZED STUDY COMPARING FAST NEUTRON RADIATION THERAPY WITH CONVENTIONAL PHOTON RADIATION THERAPY. TWENTY-SIX PATIENTS WERE RANDOMIZED TO NEUTRONS, AND 14 PATIENTS WERE RANDOMIZED TO PHOTONS. THE RANDOMIZATION WAS PURPOSEFULLY UNBALANCED IN FAVOR OF THE EXPERIMENTAL TREATMENT. THE COMPLETE RESPONSE RATE FOR THE NEUTRON-TREATED GROUP OF PATIENTS WAS 52 PERCENT. THE COMPLETE RESPONSE RATE FOR THE PHOTON-TREATED GROUP OF PATIENTS WAS 17 PERCENT. THE DIFFERENCE IS STATISTICALLY SIGNIFICANT AT THE P = .04 LEVEL. THE TWO-YEAR SURVIVAL RATES FOR THE NEUTRON-TREATED GROUP AND THE PHOTON-TREATED GROUP WERE 25 AND 0 PERCENT, RESPECTIVELY. THE MAJOR COMPLICATION RATES WERE NOT STATISTICALLY SIGNIFICANTLY DIFFERENT FOR THE TWO GROUPS (18 PERCENT FOR NEUTRONS, AND 33 PERCENT FOR PHOTONS).