Document Details
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Title:
MIXED BEAM RADIATION THERAPY FOR UNRESECTABLE SQUAMOUS CELL CARNINOMAS OF THE HEAD AND NECK: THE RESULTS OF A RANDOMIZED RTOG STUDY ( RADIATION ONOCOLOGY BIOL. PHYS. VOL.10 )
Author(s):
ANTUNEZ, A [CLEVELAND CLINIC, CLEVELAND, OH]; DAVIS, L; DAVIS, R; GRIFFIN, T W [UNIVERSITY OF WASHINGTON, SEATTLE]; HENDERICKSON, F R [ST. LUKES HOSPITAL]; LARAMORE, G E [UNIVERSITY OF WASHINGTON, SEATTLE]; MAOR, M H
Subject Terms:
HREX; NEUTRON THERAPY STUDY
Document Location:
Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV
Document Type:
JOURNAL ARTICLE
Publication Date:
Declassification Status:
Never classified
Document Pages:
0004
Accession Number:
NV0702216
OpenNet Entry Date:
1994 Aug 27
OpenNet Modified Date:
2017 Dec 21
Description/Abstract:
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