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FAST NEUTRON IRRADIATION OF METASTATIC CERVICAL ADENOPATHY: THE RESULTS OF A RANDOMIZED RTOG STUDY ( RADIATION ONOCOLOGY BIOL. PHYS. VOL.9 )

ANTUNEZ, A [CLEVELAND CLINIC, CLEVELAND, OH]; DAVIS, R; GRIFFIN, T W [UNIVERSITY OF WASHINGTON, SEATTLE]; HENDRICKSON, F R [ST. LUKES HOSPITAL]; HUSSEY, D H; LARAMORE, G E [UNIVERSITY OF WASHINGTON, SEATTLE]

HREX; NEUTRON THERAPY STUDY

Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV

JOURNAL ARTICLE

Never classified

0010

NV0702215

1994 Aug 27

2017 Dec 21

BETWEEN 1977 AND 1982, 199 EVALUABLE PATIENTS WITH MEASURABLE CERVICAL ADENOPATHY WERE ENTERED ON A PROSPECTIVE, RANDOMIZED RTOG STUDY EVALUATING THE USE OF FAST NEUTRONS IN TREATMENT OF ADVANCED, INOPERABLE SQUAMOUS CELL CARCINOMAS OF THE HEAD AND NECK REGION. ONE HUNDRED-ELEVEN PATIENTS WERE RANDOMIZED TO RECEIVE MIXED BEAM RADIATION THERAPY, AND 88 WERE RANDOMIZED TO THE PHOTON CONTROL TREATMENT. THE COMPLETE RESPONSE RATES WERE 86 PERCENT FOR MIXED BEAM VS 75 PERCENT FOR PHOTONS FOR STAGE N(1) NODES, 62 PERCENT FOR MIXED BEAM VS 48 PERCENT FOR PHOTONS FOR STAGE N(2) NODES, AND 63 PERCENT FOR MIXED BEAM VS 53 PERCENT FOR PHOTONS FOR N(3) NODES. THE PERCENTS OF PATIENTS REMAINING FREE OF THEIR ADENOPATHY FOR TWO YEARS WERE 78 PERCENT FOR MIXED BEAM VS 55 PERCENT FOR PHOTONS FOR STAGE N(1) NODES, 39 PERCENT FOR BOTH MIXED BEAM AND PHOTONS FOR N(2) NODES AND 24 PERCENT FOR MIXED BEAM VS 13 PERCENT FOR PHOTONS FOR N(3) NODES. THE MEDIAN DISEASE-FREE STATUS WAS 20.3 MONTHS FOR MIXED BEAM TREATED PATIENTS AND 6.4 MONTHS FOR PHOTON-TREATED PATIENTS. PATIENTS WHO HAD CLEARANCE OF CERVICAL ADENOPATHY SURVIVED SIGNIFICANTLY LONGER THAN THOSE WHO DID NOT.