Document Details
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Title:
PLUTONIUM CONTENT IN MARROW AND MINERALISED BONE IN AN OCCUPATIONALLY EXPOSED PERSON
Author(s):
KATHREN, R L [LOS ALAMOS NATIONAL LABORATORY]; MCINROY, J F [LOS ALAMOS NATIONAL LABORATORY]
Subject Terms:
HREX; BONE MARROW; BONES; OCCUPATIONAL WORKERS; PLUTONIUM; SKELETON
Document Location:
Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV
Document Type:
JOURNAL ARTICLE
Publication Date:
1990 Feb 12
Declassification Status:
Never classified
Document Pages:
0008
Accession Number:
NV0701394
OpenNet Entry Date:
1994 Aug 27
OpenNet Modified Date:
2017 Dec 21
Description/Abstract:
ORGANIC AND MINERAL COMPONENTS OF BONE FROM THE VERTEBRAL BODIES OF AN INDIVIDUAL WITH OCCUPATIONAL EXPOSURE TO PLUTONIUM WERE SEPARATED BY EACH OF FOUR TECHNIQUES: (1) CHEMICAL SEPARATION WITH ETHYLENEDIAMINE, (2) MECHANICAL SEPARATION BY A STREAM OF WATER, (3) MECHANICAL SEPARATION BY ULTRASONIC AGITATION, AND (4) THERMAL SEPARATION BY HEATING IN AN AUTOCLAVE: ALL SAMPLES WERE SUBJECTED TO RADIOCHEMICAL ANALYSIS FOR 239+240PU. NEARLY ALL OF THE TOTAL SKELETAL PLUTONIUM WAS ASSOCIATED WITH THE MINERAL BONE. APPROXIMATELY 3 PERCENT OF THE TOTAL SKELETAL PLUTONIUM WAS ESTIMATED TO BE RESIDENT IN THE MARROW, WITH THE CONCENTRATION IN THE RED MARROW 2-5 TIMES GREATER THAN THE CONCENTRATION IN THE YELLOW MARROW. THIS SUGGESTS THAT THE DOSE TO THE MINERALIZED PORTION OF THE BONE AND CLOSELY ASSOCIATED CELLS, INCLUDING THOSE OF THE PERIOSTEUM AND ENDOSTEUM, MAY BE AN ORDER OF MAGNITUDE OR MORE GREATER THAN THE DOSE TO THE RED MARROW, RESULTING IN A SEVERAL FOLD GREATER RISK FROM BONE TUMORIGENESIS THAN LEUKAEMIAS WHEN THE RELATIVE RISK PER UNIT DOSE IS FACTORED IN.