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Title:
COMPARISON OF ESTIMATES OF SYSTEMIC PU FROM URINARY EXCRETION WITH ESTIMATES FROM POST-MORTEM TISSUE ANALYSIS
Author(s):
HEID, K R [* PACIFIC NORTHWEST LABORATORIES]; KATHREN, R L [* PACIFIC NORTHWEST LABORATORIES]; SWINT, M J
Subject Terms:
HREX; AUTOPSIES; EXCRETION; PLUTONIUM; RETENTION; TISSUE ANALYSIS; URINALYSIS; URINE SAMPLING
Document Location:
Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV
Document Type:
JOURNAL ARTICLE
Publication Date:
Declassification Status:
Never classified
Document Pages:
0007
Accession Number:
NV0701383
OpenNet Entry Date:
1994 Aug 27
OpenNet Modified Date:
2017 Dec 21
Description/Abstract:
URINALYSIS DATA FOR 17 INDIVIDUALS WITH KNOWN EXPOSURE TO PU WERE SUPPLIED TO SIX LABORATORIES, EACH OF WHICH MADE AN ESTIMATE OF SYSTEMIC DEPOSITION. IN GENERAL, THE EVALUATION WAS DONE WITH THE LANGHAM MODEL OR ONE OF ITS DERIVATIVES, AND THE VALUES OBTAINED BY THE LABORATORIES FOR ANY SINGLE CASE WERE TYPICALLY WITHIN A FACTOR OF TWO OF THE MEAN FOR ALL LABORATORIES. THE ESTIMATES MADE FROM URINALYSIS DATA TYPICALLY WERE SEVERAL-FOLD GREATER THAN THOSE MADE FROM AUTOPSY DATA. THE RESULTS INDICATE THAT ESTIMATES BASED ON URINARY EXCRETION OVERESTIMATE SYSTEMIC DEPOSITION AND TEND TO CONFIRM PREVIOUS OBSERVATIONS THAT THE LANGHAM EQUATION UNDERESTIMATES URINARY EXCRETION.


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