Document Details
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Title:
PLUTONIUM PARTITIONING AMONG INTERNAL ORGANS
Author(s):
HEALY, J W [LOS ALAMOS NATIONAL LABORATORY]; MCINROY, J F [LOS ALAMOS NATIONAL LABORATORY]; THOMAS, R G [LOS ALAMOS NATIONAL LABORATORY]
Subject Terms:
HREX; DEPOSITION; HUMAN ORGANS; PLUTONIUM
Document Location:
Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV
Document Type:
JOURNAL ARTICLE
Publication Date:
1983 Feb 28
Declassification Status:
Never classified
Document Pages:
0006
Accession Number:
NV0701376
OpenNet Entry Date:
1994 Aug 27
OpenNet Modified Date:
2017 Dec 21
Description/Abstract:
AN ESTIMATE OF PARTITIONING OF PLUTONIUM AMONG SKELETON, LIVER, AND OTHER ORGANS IS NEEDED TO ESTIMATE THE RADIATION DOSE TO INDIVIDUAL ORGANS. THIS REVIEW WAS DONE TO PROVIDE AN ANALYSIS OF THE COEFFICIENTS CURRENTLY USED FOR THE TRANSLOCATION OF PLUTONIUM FROM BLOOD TO OTHER ORGANS AND EXCRETA. DATA FROM BOTH EXPERIMENTAL ANIMALS AND HUMAN AUTOPSY CASES WERE USED IN OUR ANALYSIS. THE ANALYSIS OF DATA FROM 257 EXPERIMENTAL ANIMAL AND 169 HUMAN SUBJECTS LED TO A CONCLUSION THAT A 70-30 PERCENT SPLIT OF PLUTONIUM DISTRIBUTION BETWEEN SKELETON AND LIVER, RESPECTIVELY, WOULD BE APPROPRIATE FOR USE IN PLUTONIUM ORGAN DISTRIBUTION MODELS. ANALYSIS OF DATA FROM OTHER ORGANS AND EARLY EXCRETA INDICATED THAT THESE OTHER COMPARTMENTS GENERALLY COMPRISED LESS THAN 3 PERCENT OF THE TOTAL EARLY BODY BURDEN. THE VARIABILITY OF PLUTONIUM DISTRIBUTION WITHIN ALL COMPARTMENTS IS EMPHASIZED, WITH THE CONCLUSION THAT THE COEFFICIENTS OF UPTAKE TO INDIVIDUAL ORGANS ARE ADEQUATE TO ESTIMATE AVERAGE ORGAN DOSES FOR AN EXPOSED POPULATION BUT USE FOR ESTIMATING DOSES FOR AN INDIVIDUAL WILL LEAD TO UNCERTAIN RESULTS.