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Title:
COMPARISON OF SYSTEMIC PLUTONIUM DEPOSITION ESTIMATES FROM URINALYSIS AND AUTOPSY DATA IN FIVE WHOLE-BODY DONORS
Author(s):
KATHREN, R L [HANFORD ENGINEERING DEVELOPMENT LABORATORY]; MCINROY, J F [LOS ALAMOS SCIENTIFIC LABORATORY]
Subject Terms:
HREX; AUTOPSIES; BIOASSAY; BODY; PLUTONIUM; TISSUE ANALYSIS; URINALYSIS; URINE SAMPLING
Document Location:
Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV
Document Type:
JOURNAL ARTICLE
Publication Date:
Declassification Status:
Never classified
Document Pages:
0008
Accession Number:
NV0701373
OpenNet Entry Date:
1994 Aug 27
OpenNet Modified Date:
2017 Dec 21
Description/Abstract:
THE SYSTEMIC DEPOSITION OF 239+240PU WAS DETERMINED BY POSTMORTEM RADIOCHEMICAL ANALYSIS OF THE TISSUES FROM FIVE WHOLE-BODY DONORS TO THE UNITED STATES TRANSURANIUM REGISTRY. ALL WERE MALES WITH INTAKES TYPICALLY OCCURRING MANY YEARS PRIOR TO DEATH. THE POSTMORTEM RADIOCHEMICAL RESULTS WERE COMPARED WITH ESTIMATES OF SYSTEMIC DEPOSITION MADE WITH 13 DIFFERENT BIOKINETIC MODELS USING URINARY EXCRETION DATA OBTAINED DURING LIFE. IN GENERAL, ESTIMATES MADE WITH OLDER BIOKINETIC MODELS WERE SEVERAL FOLD GREATER THAN THOSE OBTAINED FROM RADIO-CHEMICAL ANALYSIS OF THE TISSUES. FOR ALL FIVE CASES, AGREEMENT WITHIN A FACTOR OF TWO WITH THE TISSUE ANALYSIS RESULTS WAS OBTAINED WITH TWO OF THE TISSUES. FOR ALL FIVE CASES, AGREEMENT WITHIN A FACTOR OF TWO WITH THE TISSUE ANALYSIS RESULTS WAS OBTAINED WITH TWO OF THE BIOKINETIC MODELS EVALUATED: THE LANGHAM POWER FUNCTION MODEL AS MODIFIED BY LEGGETT AND ECKERMAN AND THE TWO COMPARTMENT EXPONENTIAL MODEL PROPOSED IN ICRP PUBLICATION NOS. 19 AND 30.


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