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Title:
DISTRIBUTION AND EXCRETION OF PLUTONIUM ADMINISTERED INTRAVENOUSLY TO MAN ( CASE NO. 40-010 )
Subject Terms:
HREX; EXCRETION; HUMANS; PLUTONIUM; PLUTONIUM INJECTION EXPERIMENT; RADIATION DOSE DISTRIBUTION
Document Location:
Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV
Document Type:
LEGAL DOCUMENT
Publication Date:
1950 Sep 20
Declassification Status:
Never classified
Document Pages:
0023
Accession Number:
NV0700911
OpenNet Entry Date:
1994 Aug 27
OpenNet Modified Date:
2012 May 14
Description/Abstract:
THIS IS A SCIENTIFIC REPORT DATED SEPTEMBER 20, 1950. THIS REPORT IS A COOPERATIVE RESEARCH PROJECT STARTED UNDER THE MANHATTAN ENGINEERING DISTRICT AND COMPLETED UNDER CONTRACT FOR THE ATOMIC ENERGY COMMISSION. THE PURPOSE OF THIS STUDY WAS TO ESTABLISH THE MAXIMUM PERMISSIBLE BODY BURDEN FOR PLUTONIUM, VERIFY AND QUALIFY PAST ANIMAL RESEARCH DATA, PROVIDE THE BASIS FOR QUANTIFYING THE DEGREE OF EXPOSURE TO PLUTONIUM, PROVIDE MORE DATA, AND QUANTIFY THE EXISTING DATA ON THE DEPOSITION AND EXCRETION OF PLUTONIUM BY MAN. IT WAS DETERMINED THAT THE INFORMATION NEEDED COULD ONLY BE GAINED BY ADMINISTERING SMALL AMOUNTS OF PLUTONIUM TO TWELVE INDIVIDUALS WITH A RELATIVELY SHORT LIFE EXPECTANCY. THE STUDY WAS CONDUCTED BY A JOINT VENTURE BETWEEN THE LOS ALAMOS SCIENTIFIC LABORATORY OF THE UNIVERSITY OF CALIFORNIA AND THE ATOMIC ENERGY PROJECT OF THE UNIVERSITY OF ROCHESTER. THE DATA WAS GAINED BY ANALYSIS OF VARIOUS BIOASSAY SAMPLES TAKEN BEFORE AND AFTER THE INJECTION OF PLUTONIUM. AS A RESULT OF THE STUDY THE EXCRETION RATE FOR PLUTONIUM AND THE DISTRIBUTION OF PLUTONIUM IN THE HUMAN BODY WAS DETERMINED. RESULTS OF THE STUDY WERE CORRELATED WITH DATA FROM OTHER STUDIES TO DETERMINE DOSAGE AND BODY BURDEN FOR PLUTONIUM.


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