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THE DISTRIBUTION AND EXCRETION OF PLUTONIUM IN TWO HUMAN SUBJECTS ( GOOD COPY IS 700191 ) ( CASE NO. 40-004 )

NICKSON, J J; RUSSELL, E R

HREX; AUTOPSY; DEATH; EXCRETION; HUMANS; MEDICAL SURVEILLANCE; NEOPLASM; PATIENTS; PLUTONIUM; PLUTONIUM INJECTION EXPERIMENT; RADIATION DOSE DISTRIBUTION; RADIOBIOLOGY

Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV

LEGAL DOCUMENT

1946 Oct 02

Never classified

0029

NV0700644

1994 Aug 27

2017 Dec 21

REPORT FROM ARGONNE NATIONAL LABORATORY ON "THE DISTRIBUTION AND EXCRETION OF PLUTONIUM IN TWO HUMAN SUBJECTS" BY E R RUSSELL AND J J NICKSON, ASSISTED BY W MONROE, R LESKO AND L O JACOBSON. THE FIRST THREE PAGES ARE ILLEGIBLE. THE GOOD COPY OF THIS DOCUMENT IS NUMBERED 700191. THE DOCUMENT CONTAINS A TABLE OF CONTENTS AND TWO CASE STUDIES. CASE NUMBER ONE IS A 68-YEAR OLD WHITE MALE WHO WAS ADMITTED TO THE HOSPITAL FOR SURGICAL TREATMENT OF A RECURRENT EPITHELIOMA OF THE BUCUS MUCOSA. SURGERY WAS PERFORMED ON 11 AND 28 APR 45, AND ON 26 APR THE PATIENT WAS GIVEN A PLUTONIUM INJECTION. THE PATIENT DIED ON 3 OCT 45. AN AUTOPSY WAS PERFORMED AND THE FINDINGS ARE NOTED IN THE REPORT. CASE NUMBER TWO WAS A 55-YEAR OLD WHITE FEMALE WHO WAS ADMITTED TO THE HOSPITAL IN DEC 45 FOR DIAGNOSIS AND TREATMENT OF LYMPHADENOPATHY. ON 27 DEC 45 SHE WAS INTRAVENOUSLY INJECTED WITH PLUTONIUM. THE PATIENT DIED ON 13 JAN 45 (YEAR QUESTIONABLE). THE MAJOR AUTOPSY FINDINGS ARE NOTED IN THE REPORT. AN UNUSUAL FINDING WAS THAT THE PATIENT HAD TWO CO-EXISTING PRESUMABLE INDEPENDENT TUMORS. THE POST MORTEM SHOWED NO EVIDENT DIFFERENCE IN THE CHARACTER OF THE TUMOR FOLLOWING THE INJECTION OF PLUTONIUM. THE METHODS OF STUDY FOR EACH CASE ARE DOCUMENTED AND COMPARED IN THE REPORT. THE RESULTS FOR CASE NUMBER I WERE REACHED BY STUDYING EXCRETION OF PLUTONIUM IN THE URINE, FECAL PLUTONIUM EXCRETION, AND CLINICAL STUDIES OF PERIPHERAL BLOOD. TABLES AND CHARTS AUGMENT THE FINDINGS. THE RESULTS OF THE STUDY OF CASE 2 WERE DETERMINED BY EXCRETION STUDIES AS WELL AS STUDIES OF THE PERIPHERAL BLOOD. THE DISTRIBUTION OF PLUTONIUM IN THE TISSUE IS ALSO NOTED. AGAIN CHARTS AND TABLES AUGMENT THE FINDINGS. A DISCUSSION IS INCLUDED AT THE END OF THE REPORT WHICH STATES THAT THE FINDINGS OF THIS REPORT MAY NOT BE APPLICABLE TO THE POPULATION BECAUSE THE TWO STUBJECTS HAD CARCINOMAS AND THE MAJORITY OF OCCUPATIONALLY EXPOSED PEOPLE WILL GENERALLY BE IN BETTER HEALTH. THE CLINICAL PICTURE, INSOFAR AS CAN BE DETERMINED, THE CLINICAL COURSE IN NEITHER OF THE TWO CASES WAS INFLUENCED BY THE INJECTION OF PLUTONIUM. THE SUMMARY AND CONCLUSIONS ARE NOTED AT THE END OF THE REPORT. A BIBLIOGRAPHY IS ALSO INCLUDED.