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Title:
HEALTH PHYSICS ARTICLE, INVITED DISCUSSION - THE BIOLOGICAL IMPLICATIONS OF THE TRANSURANIUM ELEMENTS FOR MAN ( HEALTH PHYSICS PERGAMON PRESS 1972. VOL. 22 (JUNE), PP. 943-952 )
Author(s):
LANGHAM, W H [UNIVERSITY OF CALIFORNIA]
Subject Terms:
HREX; BIOLOGICAL RADIATON EFFECTS; HUMANS; INTERVIEWS; ISOTOPES; RADIOACTIVITY; SYMPOSIUM; TRANSURANIUM ELEMENTS
Document Location:
Location - NNSA/NSO Nuclear Testing Archive Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - CIC@NV.DOE.GOV
Document Type:
JOURNAL ARTICLE
Publication Date:
Declassification Status:
Never classified
Document Pages:
0012
Accession Number:
NV0700113
Originating Research Org.:
HEALTH PHYSICS
OpenNet Entry Date:
1994 Aug 27
Description/Abstract:
THE BIOLOGICAL IMPLICATIONS ON MAN OF USING TRANSURANIUM ELEMENTS AS AN ALTERNATIVE POWER SOURCE IS EXAMINED. IN EARLY OBSERVATIONS OF HUMAN CASES OF RADIUM EXPOSURE, SIGNS OF DAMAGE AND EVEN DEATH MAY OCCUR WITH BODY BURDENS OF 1 UG OF RADIUM FIXED IN THE BONE FOR SEVERAL YEARS. PLUTONIUM, LIKE RADIUM, CONCENTRATED IN BONE WOULD BE EXPECTED TO PRODUCE SIMILAR TYPES OF BONE LESIONS, INCLUDING OSTEOGENIC SARCOMA. THE QUESTION OF THE EFFECTS OF ATMOSPHERIC INHALATION AND RE-DEPOSITION OF PLUTONIUM IS INTRODUCED. IN 1949 IT WAS REPORTED THAT COMPARATIVE TOXICITY STUDIES IN MICE AND RATS SUGGESTED A TOXICITY RATIO BETWEEN EQUAL MICROCURIE AMOUNTS OF PLUTONIUM AND RADIUM OF APPROXIMATELY 15 TO 1. ON THIS BASIS, A BODY BURDEN OF 0.1 UG WAS ADOPTED. HOWEVER, RADON RETENTION FOR MAN IS 50 PERCENT AS COMPARED FROM 15 TO 20 PERCENT FOR RODENTS. BASED UPON THIS, IT WAS DETERMINED THAT THE MAXIMUM PERMISSIBLE RETAINED DOSE OF PLUTONIUM IN MAN IS 0.04 UC, WHICH DEPENDS UPON THE CORRESPONDING PERMISSIBLE DOSE OF RADIUM, ESTABLISHED AT 0.1 UC UP THROUGH 1972.


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