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Title:
THE DISTRIBUTION OF PU-239 IN THE BODY FOLLOWING EXPOSURE BY INHALATION ( HEALTH PHYSICS PERGAMON PRESS 1964, VOL. 10 PP 1035-1041 )
Author(s):
SNYDER, W S [OAK RIDGE NATIONAL LABORATORY]
Subject Terms:
HREX; ABSORPTION; AEROSOL; ARTICLE; AUTOPSY; BODY BURDEN; DIGESTIVE SYSTEM; HUMANS; INHALATION; ORGANS; PLUTONIUM; PLUTONIUM 239; RADIATION DOSE DISTRIBUTION; RESPIRATORY SYSTEM
Document Location:
Location - NNSA/NSO Nuclear Testing Archive Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - CIC@NV.DOE.GOV
Document Type:
JOURNAL ARTICLE
Publication Date:
Declassification Status:
Never classified
Document Pages:
0008
Accession Number:
NV0700112
Originating Research Org.:
HEALTH PHYSICS
OpenNet Entry Date:
1994 Aug 27
Description/Abstract:
APPLYING THE STANDARD LUNG MODEL, A SOLUBLE AEROSOL DEPOSITED IN THE LUNG IS ABSORBED INTO THE BLOOD, BUT SOME FRACTION OF THE MORE INSOLUBLE DEPOSITS REMAINS IN THE LUNG FOR LONG PERIODS OF TIME. CONVENTIONALLY, AN ELIMINATION HALF-TIME OF 120 DAYS IS ASSUMED FOR THESE "INSOLUBLE" DEPOSITS, AND IT IS ASSUMED FURTHER THAT ULTIMATELY MOST OF THIS MATERIAL IS ELIMINATED VIA THE GASTROINTESTINAL TRACT. AS A RESULT, BONE IS NOT CONSIDERED TO BE THE CRITICAL ORGAN FOR MOST INSOLUBLE AEROSOLS OF 239 PU OR OTHER HEAVY METALS. RECENT WORK INDICATES THAT THERE MAY BE A SIGNIFICANT FRACTION OF THESE "INSOLUBLE" DEPOSITS REACHING THE BLOOD, AND THUS THERE IS THE POSSIBILITY OF A SIGNIFICANT BONE BURDEN. AT FIRST GLANCE, THE AVAILABLE AUTOPSY DATA ON HUMAN EXPOSURE MIGHT SEEM TO CONFLICT WITH THE ABOVE INTERPRETATION. HOWEVER, A DETAILED DATA ANALYSIS OF A HUMAN EXPOSURE RECORD INDICATES THAT THE ABOVE INTERPRETATION MAY BE CORRECT. ALTHOUGH THE SUBJECT'S SKELETON SHOWED A SMALLER CONCENTRATION THAN DID THE LIVER, LUNG, OR PULMONARY LYMPH NODES, THIS DOES NOT EXCLUDE THE SKELETON AS THE CRITICAL ORGAN. APPLYING THE METABOLIC MODEL, THE LUNG WOULD BE EXPECTED TO HAVE A HIGHER CONCENTRATION THAN BONE IN THE EARLY YEARS OF EXPOSURE, ALTHOUGH THE LATTER WOULD CONTINUE TO INCREASE AND MIGHT BECOME THE LIMITING CRITERION GOVERNING CONTINUOUS EXPOSURE FOR A WORKING LIFE. THE EVIDENCE FOR AND AGAINST THIS HYPOTHESIS IS DISCUSSED IN SOME DETAIL.


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