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Title:
ARTICLE IN THE BRITISH JOURNAL OF RADIOLOGY: EXCRETION METHODS THE APPLICATION OF EXCRETION ANALYSES TO THE DETERMINATIONS OF BODY BURDEN OF RADIOACTIVE ISOTOPES
Author(s):
LANGHAM, W H [UNIVERSITY OF ROCHESTER]
Subject Terms:
HREX; ANIMALS; BODY BURDEN; EXCRETION; HUMANS; QUANTITATIVE ANALYSIS; RADIOACTIVE ISOTOPES
Document Location:
Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV
Document Type:
REPORT
Publication Date:
Declassification Status:
Never classified
Document Pages:
0019
Accession Number:
NV0700109
OpenNet Entry Date:
1994 Aug 27
OpenNet Modified Date:
2012 May 14
Description/Abstract:
NINETEEN-PAGE ARTICLE "THE APPLICATION OF EXCRETION ANALYSES TO THE DETERMINATION OF BODY BURDEN OF RADIOACTIVE ISOTOPES" WRITTEN BY WRIGHT H. LANGHAM, PH.D., PUBLISHED IN THE BRITISH JOURNAL OF RADIOLOGY 1957. APPLICATION OF EXCRETION ANALYSES TO THE QUANTITATIVE ESTIMATION OF TOTAL BODY BURDEN REQUIRES A PRIOR KNOWLEDGE OF THE EXCRETION RATE, PREFERABLY BY MAN, OF THE MATERIAL IN QUESTION. THE EXCRETION RATE OF SPECIFIC RADIOACTIVE NUCLIDES BY MAN IS NOT ALWAYS AVAILABLE, SO THAT IT IS NECESSARY TO USE DATA COLLECTED FROM EXPERIMENTAL ANIMALS. EXTRAPOLATION OF ANIMAL DATA TO MAN IS SUBJECT TO CONSIDERABLE CRITICISM. THERE IS NO WAY TO CIRCUMVENT SUCH CRITICISM, HOWEVER, UNTIL ADEQUATE EXPERIMENTAL DATA HAVE BEEN COLLECTED FROM HUMAN SUBJECTS.