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Title:
A COMPARISON OF THE METABOLISM OF PLUTONIUM ( PU258 ) IN MAN AND THE RAT
Subject Terms:
HREX; ANIMALS; BONE TISSUES; EXCRETION; HUMANS; INTERNAL IRRADIATION; MEDICAL SURVEILLANCE; METABOLISM; PLUTONIUM; PLUTONIUM 258; PLUTONIUM INJECTION EXPERIMENT; RETENTION; SKELETON; URINALYSIS
Document Location:
Location - NNSA/NSO Nuclear Testing Archive Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - CIC@NV.DOE.GOV
Document Type:
REPORT
Publication Date:
1946 May 31
Declassification Status:
Never classified
Document Pages:
0016
Accession Number:
NV0700098
OpenNet Entry Date:
1994 Aug 27
Description/Abstract:
FIFTEEN-PAGE REPORT "A COMPARISON OF THE METABOLISM OF PLUTONIUM (PU- 238) IN MAN AND THE RAT" WRITTEN BY J. CROWLEY, H. LANZ, K. SCOTT, AND J. G. HAMILTON, NO DATE GIVEN. THE FATE OF PLUTONIUM INJECTED INTRAVENOUSLY INTO A HUMAN SUBJECT AND INTO RATS WAS FOLLOWED IN PARALLEL STUDIES. THE DISTRIBUTION OF PLUTONIUM AMONG THE TISSUES OF THE BODY AND THE AVERAGE DAILY RATE OF EXCRETION OF THIS ELEMENT ARE COMPARED IN MAN AND IN RATS. IN GENERAL, THE RESULTS OF THESE EXPERIMENTS SHOW A HIGH DEGREE OF PROLONGED RETENTION OF PLUTONIUM IN THE BODY, WITH SELECTIVE DEPOSITION IN THE SKELETON, ESPECIALLY IN THE REGION ADJACENT TO THE BONE MARROW IN THE ENDOSTEUM AND TRABECULAR BONE. THE ELIMINATION OF PLUTONIUM FROM THE BODY OCCURS AT HIGHER RATES IN RATS THAN IN MAN. DURING THE COURSE OF THESE STUDIES, RATS ELIMINATED 50 PERCENT OF THE PLUTONIUM ADMINISTERED, WHEREAS IN THE PARALLEL EXPERIMENT IN MAN, ONLY ABOUT 5 PERCENT WAS EXCRETED. THE ELIMINATION OF PLUTONIUM IS PRIMARILY VIA THE FECES IN RATS, WHEREAS IN MAN THE MAJOR ELIMINATION OF PLUTONIUM OCCURS VIA THE URINE.


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