Document Details
Title:
BIOASSAY DATA AND A RETENTION - EXCRETION MODEL FOR SYSTEMIC PLUTONIUM
Author(s):
LEGGETT, R W [OAK RIDGE NATIONAL LABORATORY]
Document Location:
Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV
Document Type:
REPORT
Publication Date:
1984 May 31
Declassification Status:
Never classified
Document Pages:
0096
Accession Number:
NV0091622
Document Number(s):
NUREGCR3346
Originating Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
OpenNet Entry Date:
1994 Aug 27
OpenNet Modified Date:
2003 Sep 18
Description/Abstract:
THE ESTIMATION OF SYSTEMIC BURDENS FROM URINALYSES HAS BEEN THE MOST C OMMON AND USEFUL METHOD OF QUANTIFYING OCCUPATIONAL EXPOSURES TO PLUTO NIUM. PROBLEMS ARISE IN USING THIS TECHNIQUE, HOWEVER, BECAUSE OF INAD EQUATE MODELING OF HUMAN RETENTION, TRANSLOCATION, AND EXCRETION OF TH IS ELEMENT. PRESENT METHODS FOR ESTIMATING THE SYSTEMIC BURDEN FROM UR INALYSES WERE DERIVED TO A LARGE EXTENT FROM PATTERNS OBSERVED IN THE FIRST FEW MONTHS AFTER EXPOSURE, BUT THERE IS NOW EVIDENCE THAT THESE SAME PATTERNS DO NOT PERSIST OVER LONG PERIODS. IN FACT, RECENT COMPA RISONS OF AUTOPSY DATA WITH URINALYSES SUGGEST THAT EXTRAPOLATION TO E XTENDED PERIODS BASED ON THESE OBSERVED PATTERNS USUALLY LEADS TO A LA RGE OVERESTIMATE OF THE SYSTEMIC BURDEN AT TIMES MORE THAN A FEW YEARS AFTER EXPOSURE. IN THIS REPORT WE COLLECT AND DISCUSS HUMAN AND ANIMA L DATA FOR PLUTONIUM TOGETHER WITH GENERAL PHYSIOLOGICAL PROPERTIES NE EDED FOR THE INTERPRETATION OF BIOASSAY RESULTS. THIS INFORMATION IS U SED TO DEVELOP A MECHANISTIC MODEL OF THE MOVEMENT, RETENTION, AND EXC RETION OF SYSTEMIC PLUTONIUM. THIS MODEL APPEARS TO BE A REASONABLY AC CURATE PREDICTOR OF EXCRETION FOR TIMES RANGING FROM ONE DAY TO SEVERA L DECADES AFTER INTRODUCTION OF SOLUBLE PLUTONIUM TO BLOOD. THE MODEL MAY BE USED IN CONJUNCTION WITH EXISTING MODELS AND/OR CASE-SPECIFIC INFORMATION CONCERNING TRANSLOCATION FROM THE RESPIRATORY AND GASTROI NTESTINAL TRACTS OR FROM WOUNDS TO THE BLOODSTREAM. DESPITE THE IMPROV EMENTS OVER PREVIOUS RETENTION MODELS, SIGNIFICANT UNCERTAINTIES REMAI N REGARDING SOME ASPECTS OF THE MOVEMENT OF PLUTONIUM IN THE BODY, PAR TICULARLY ITS TRANSPORT FROM THE LIVER. AN ATTEMPT HAS BEEN MADE TO CO NSTRUCT AND ANALYZE THE MODEL IN SUCH A WAY AS TO ELUCIDATE THOSE AREA S NEEDING FURTHER ATTENTION.