Document Details


Title:
THYROID NEOPLAISA IN MARSHALL ISLANDERS EXPOSED TO NUCLEAR FALLOUT ( JAMA, AUGUST 7, 1987, VOL. 258, NO. 5 )
Author(s):
HAMILTON, T E [UNIVERSITY OF WASHINGTON, SEATTLE]; VANBELLE, G [UNIVERSITY OF WASHINGTON, SEATTLE]; LOGERFO, J P [UNIVERSITY OF WASHINGTON, SEATTLE]
Subject Terms:
CASTLE OPERATION; BRAVO EVENT; THYROID; NEOPLASMS; BIOLOGICAL RADIATION EFFECTS; IODINE 131; IODINE 132; IODINE 133; IODINE 135; RESEARCH PROGRAMS; HUMAN POPULATIONS; PROBABILITY; CALCULATION METHODS; RISKS
Document Location:
Location - NNSA/NSO Nuclear Testing Archive Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - CIC@NV.DOE.GOV
Document Type:
JOURNAL ARTICLE
Publication Date:
1987 Aug 07
Declassification Status:
Never classified
Document Pages:
0008
Accession Number:
NV0067397
Originating Research Org.:
JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
OpenNet Entry Date:
1994 Aug 26
Description/Abstract:
WE STUDIED THE RISK OF THYROID NEOPLASIA IN MARSHALL ISLANDERS EXPOSED TO RADIOIODINES IN NUCLEAR FALLOUT FROM THE BRAVO THERMONUCLEAR TEST. WE SCREENED 7266 MARSHALL ISLANDERS FOR THRYOID NODULES; THE ISLANDER S WERE FROM 14 ATOLLS, INCLUDING SEVERAL SOUTHERN ATOLLS, WHICH WERE T HE SOURCE OF THE BEST AVAILABLE UNEXPOSED COMPARISON GROUP. USING A R ETROSPECTIVE COHORT DESIGN, WE DETERMINED THE REVALENCE OF THYROID NOD ULARITY IN A SUBGROUP OF 2273 PERSONS WHO WERE ALIVE IN 1954 AND WHO T HEREFORE WERE POTENTIALLY EXPOSED TO FALLOUT FROM THE BRAVO TEST. FOR THOSE 12 ATOLLS PREVIOUSLY THOUGHT TO BE UNEXPOSED TO FALLOUT, THE PR EVALENCE OF THYROID NODULES RANGED FROM 0.9 PERCENT TO 10.6 PERCENT. USING THE DISTANCE OF EACH ATOLL FROM THE TEST SITE AS A PROXY FOR THE RADIATION DOSE TO THE THYROID GLAND, A WEIGHTED LINEAR REGRESSION SHO WED AN INVERSE LINEAR RELATIONSHIP BETWEEN DISTANCE AND THE AGE-ADJUST ED PREVALENCE OF THYROID NODULES. DISTANCE WAS THE STRONGEST SINGLE P REDICTOR IN LOGISTIC REGRESSION ANALYSIS. A NEW ABSOLUTE RISK ESTIMAT E WAS CALCULATED TO BE 1100 EXCESS CASES/GY/Y/1*10**6 PERSONS (11.0 EX CESS CASES/RAD/Y/1 MILLION PERSONS), 33 PERCENT HIGHER THAN PREVIOUS E STIMATES. WE CONCLUDE THAT AN EXCESS OF THYROID NODULES WAS NOT LIMIT ED ONLY TO THE TWO NORTHERN ATOLLS BUT EXTENDED THROUGHOUT THE NORTHER N ATOLLS; THIS SUGGESTS A LINEAR DOSE-RESPONSE RELATIONSHIP.


<< Return to Search Results