Document Details


Title:
A PREDICTION OF EARLY RADIATION LETHALITY USING AN EFFECTIVE DOSE
Document Location:
Location - NNSA/NSO Nuclear Testing Archive Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - CIC@NV.DOE.GOV
Document Type:
REPORT
Publication Date:
1964 Sep 30
Declassification Status:
Unknown
Document Pages:
0038
Accession Number:
NV0025620
Document Number(s):
TABR4
Originating Research Org.:
ATOMIC ENERGY COMMISSION-DIVISION OF BIOLOGY AND M
OpenNet Entry Date:
1994 Aug 26
Description/Abstract:
THE PREDICTION OF THE INCIDENCE OF EARLY DEATH IN A MAMMALIAN SPECIES FOLLOWING EXPOSURE TO IONIZING RADIATION TO THE WHOLE BODY FROM AN EXT ERNAL SOURCE HAS BEEN PURSUED FOR BOTH APPLIED AND INVESTIGATIVE PURPO SES. THIS PAPER, EMPHASIZING THE DEPENDENCE OF THE LETHAL RESPONSE ON THE TIME CHARACTERISTICS OF THE EXPOSURE DOSE, CONSIDERS JOINTLY (1) S OME IMPLICATIONS OF A LONG-STANDING HYPOTHESIS OF H. A. BLAIR ON RECOV ERY FROM RADIATION INJURY AND (2) THE INTERPRETATION OF EXPERIMENTS TO ESTIMATE QUANTAL-RESPONSE RADIATION-TOLERANCE DISTRIBUTION. THE USUAL METHOD FOR MAKING PRACTICAL PREDICTIONS OF EARLY LETHALITY BASED UPON "EQUIVALENT RESIDUAL DOSE" OR "BIOLOGICAL DAMAGE DOSE" DEPENDS UPON A TACIT ASSUMPTION OF CONSTANT VARIANCE FOR THE UNDERLYING TOLERANCE DIS TRIBUTIONS. THERE IS EVIDENCE SUGGESTING THAT SUCH AN ASSUMPTION IS AT BEST FRAGILE. FUTURE EXPERIMENTS ARE NEEDED AND SHOULD BE DESIGNED TO LEAD TO CONCLUSIONS ABOUT THE VALIDITY OF (1) THE BLAIR HYPOTHESIS, I NCLUDING THE PROPER VALUES FOR THE ARBITRARY CONSTANTS, FOR A WIDER RA NGE OF EXPOSURE CHARACTERISTICS AND END POINTS AND (2) THE ASSUMPTION OF CONSTANT VARIANCE FOR THE ASSOCIATED TOLERANCE DISTRIBUTIONS.


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