Document Details
Title:
GROSS DEVELOPMENTAL ANOMALIES INDUCED BY STRONTIUM-90 IN THE RAT EMBRYO
Author(s):
Document Location:
Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV
Document Type:
REPORT
Publication Date:
1964 Apr 10
Declassification Status:
Never classified
Document Pages:
0020
Accession Number:
NV0016120
Document Number(s):
URENG492
Originating Research Org.:
Univ. of Rochester, NY (United States)
OpenNet Entry Date:
1994 Aug 26
OpenNet Modified Date:
2003 Sep 18
Description/Abstract:
GROSS LOCALIZED DEVELOPMENTAL ANAMOLIES AND GENERALIZED STUNTING WERE OBSERVED IN RAT FETUSES ON THE 20TH POST-CONCEPTION DAY FOLLOWING THE INTRAVENOUS INJECTION OF 191 OR 382 MICROCURIES OF STRONTIUM-90 INTO D AMS ON DAY 2 OR DAY 10 POST-CONCEPTION. INJECTION ON DAY 2 POST-CONCEP TION PRODUCED SIGNIFICANT GENERAL STUNTING IN 13.2 PERCENT OF A TOTAL OF 76 FETUSES AFTER A DOSE OF 191 MICROCURIES, AND IN 23.3 PERCENT OF 30 FETUSES AFTER A DOSE OF 382 MICROCURIES, COMPARED TO AN INCIDENCE O F 5 PERCENT IN 159 CONTROL FETUSES EXAMINED. INJECTION ON DAY 10 POST- CONCEPTION PRODUCED A SIGNIFICANT INCIDENCE OF VARIOUS SPECIFIC LOCALI ZED DEVELOPMENTAL ANOMALIES IN ADDITION TO GENERALIZES STUNTING. A TOTAL OF 17.6 PERCENT (12/68) AND 51.0 PERCENT (49/96) OF THE FETUSES WERE ANOMALOUS OR STUNTED IN THE GROUPS THAT RECEIVED 191 AND 382 MICR OCURIES OF STRONTIUM-90, RESPECTIVELY, AS COMPARED TO A 3.1 PERCENT IN CIDENCE (5/159) IN CONTROLS. THE MOST COMMON EFFECTS OF STRONTIUM-90 O BSERVED WERE, IN DECREASING ORDER OF FREQUENCY, TAILLESSNESS, RETARDED GROWTH (GENERALIZED STUNTING), REDUCED EYE VOLUME, SKELTAL DEFECTS AND INTERSCAPULAR DEPRESSION. THE INCIDENCE OF DEFECTIVE FETUSES OBSERVED WAS APPARENTLY RELATED TO THE DOSE OF STRONTIUM-90 TO THE DAM AND TO THE GESTATION STAGE AT TIME OF INJECTION.