Document Details
Title:
MINIATURE PIG PERFORMANCE AFTER FRACTIONATED DOSES OF IONIZING RADIATION
Author(s):
Document Location:
Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV
Document Type:
REPORT
Publication Date:
1969 Dec 31
Declassification Status:
Never classified
Document Pages:
0020
Accession Number:
NV0015747
Document Number(s):
AFRRISR6922
Originating Research Org.:
ARMED FORCES RADIOBIOLOGY RESEARCH INSTITUTE
OpenNet Entry Date:
1994 Aug 26
OpenNet Modified Date:
2003 Sep 18
Description/Abstract:
MINIATURE PIGS WERE TRAINED TO TRAVERSE ON CUE A TWO-CHAMBERED SHUTTLE BOX. THE PIGS RECEIVED EITHER UNFRACTIONATED (6500, 8600, 11,600 OR 13 ,000 RADS) OR FRACTIONATED (6800, 8500, 11,000, OR 13,300 RADS) DOSES OF PULSES MIXED GAMMA-NEUTRON RADIATION. THE FRACTIONATED DOSES WERE D ELIVERED AS TWO EQUAL FRACTIONS 5 HOURS APART. MINIATURE PIG PERFORMAN CE AFTER THE SECOND HALF OF THE FRACTIONATED DOSE WAS SIMILAR TO OR BE TTER THAN THE PERFORMANCE OBSERVED AFTER THE FIRST HALF OF THE DOSE. T HE PIG"S PERFORMANCE WAS MARKEDLY BETTER WHEN THE DOSE WAS FRACTIONATE D THAN WHEN IT WAS UNFRACTIONATED; EARLY TRANSIENT INCAPACITATION WAS SHORTER, AND ACCEPTABLE PERFORMACE WAS ACHIEVED EARLIER AND LASTED LONGER. ALSO, MEAN SURVIVAL TIMES OF THE PIGS THAT RECIEVED FRACTIONAT ED DOSES WERE LONGER. POSSIBLE MECHANISMS WHICH MAY BE RESPONSIBLE FOR THE REDUCED EFFECTIVENESS OF THE FRACTIONATED DOSES ARE DISCUSSED.