Document Details
Title:
IN VITRO MOTOR ACTIVITY OF RAT SMALL INTESTINE FOLLOWING WHOLE-BODY X IRRADIATION
Author(s):
Document Location:
Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV
Document Type:
REPORT
Publication Date:
1969 Oct 31
Declassification Status:
Never classified
Document Pages:
0022
Accession Number:
NV0015743
Document Number(s):
AFRRISR6915
Originating Research Org.:
ARMED FORCES RADIOBIOLOGY RESEARCH INSTITUTE
OpenNet Entry Date:
1994 Aug 26
OpenNet Modified Date:
2003 Sep 18
Description/Abstract:
IN VITRO CONTRACTIONS OF SMALL INTESTINAL SEGMENTS WERE STUDIED AT VAR YING TIMES FOLLOWING EXPOSURE OF RATS TO WHOLE-BODY X IRRADIATION. JEJ UNAL CONTRACTIONS WERE MEASURED 20 TO 40 MINUTES, 4 TO 6 HOURS, 1 DAY, 2 DAYS, 3 DAYS, 5 DAYS, 7 DAYS, 11 DAYS AND 30 DAYS FOLLOWING 25 R, 1 00 R, AND 700 R, AS WELL AS DURING THE FIRST 3 DAYS FOLLOWING 1500 R. DUODENUM AND ILEUM WERE STUDIED 2 AND 3 DAYS FOLLOWING 1500 R. SHAM IR RADIATD RATS SERVED AS CONTROLS. THE IRREGULAR "MULTICOMPONENT" CONTRA CTION PATTERN CHARACTERISTIC OF JEJUNAL SEGMENTS FROM NONIRRADIATED RA TS WAS CHANGED TO A MORE REGULAR PATTERN 2 AND 3 DAYS AFTER 1500 R, 70 0 R, AND 100 R; IN ADDITION, EXPOSURES WITH 1500 R AND 700 R INCREASED CONTRACTION AMPLITUDE. TWO AND THREE DAYS FOLLOWING 1500 R, DUODENAL B UT NOT ILEAL SEGMENTS SHOWED INCREASED REGULARITY. FURTHERMORE, THE GR ADIENT OF CONTRACTION FREQUENCY (DUODENUM-JEJUNUM-ILEUM) WAS MAINTAINE D, BUT THE GRADIENT OF CONTRACTION REGULARITY (ILEUM-JEJUNUM-DUODENUM) WAS CHANGED. CHANGES IN SMALL INTESTINAL MOTOR FUNCTION FOLLOWING WHOL E-BODY RADIATION MAY SIGNIFICANTLY CONTRIBUTE TO THE PATHOPHYSIOLOGY O F INTESTINAL RADIATION INJURY.