Document Details
Title:
RE-EVALUATION OF CERTAIN ASPECTS OF IODINE METABOLISM
Author(s):
Subject Terms:
IODINE 131; THYROID; ANIMALS; RODENTS; IODINE; FOOD; BIOLOGICAL MATERIALS; DIET; METABOLISM; BIOCHEMISTRY; BODY FLUIDS; EXCRETION; URINE
Document Location:
Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV
Document Type:
REPORT
Publication Date:
1960 Dec 31
Declassification Status:
Unknown
Document Pages:
0028
Accession Number:
NV0005209
Originating Research Org.:
Univ. of Tennessee, Knoxville, TN (United States)
OpenNet Entry Date:
1994 Aug 26
OpenNet Modified Date:
2003 Sep 18
Description/Abstract:
A HIGHLY PURIFIED LOW-IODINE DIET WAS PREPARED AND FED TO RATS FOR 8 W EEKS IN ORDER TO MEASURE ACUTE CHANGES IN IODINE METABOLISM. RECOVERY OF DIETARY IODINE WAS MEASURED BY ADDITION OF RADIOACTIVE I-131 TO TH E FOOD, AND THIS RECOVERY WAS DISAPPOINTINGLY POOR. SINCE I-131 WAS AD DED TO THE DIET TO MEASURE RECOVERY OF IODINE DURING CHEMICAL ANALYSIS , IT WAS DECIDED TO MIX I-131 WITH THE DIET AND FEED IT TO THE ANIMALS UNTIL THEIR THYROID GLANDS CONCENTRATED THE DIETARY IODINE. IT WAS HO PED THIS WOULD ALLOW FOR DEPENDABLE CHEMICAL DETERMINATIONS TO BE PERF ORMED. SOME FECAL IODINE EXCRETED BY RATS FED COMMERCIAL CHOW APPEARED TO BE DERIVED FROM UNABSORBED DIETARY IODINE PRESENT IN THE DIET IN A N UNDETERMINED STATE.