Document Details
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Title:
METABOLIC CHANGES IN HUMANS FOLLOWING TOTAL BODY IRRADIATION, 1 MAY 1963 - 29 FEBRUARY 1964 (DASA 1633M
Author(s):
Subject Terms:
BLOOD STUDIES
Document Location:
Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV
Document Type:
REPORT
Publication Date:
1964 Jan 01
Declassification Status:
Unknown
Document Pages:
0042
Accession Number:
NV0757935
Document Number(s):
DASA-1633
Originating Research Org.:
DEFENSE NUCLEAR AGENCY, U.S.
OpenNet Entry Date:
1999 Jul 13
OpenNet Modified Date:
2003 Sep 18
Description/Abstract:
THIS REPORT DESCRIBES STUDIES DESIGNED TO OBTAIN INFORMATION NECESSARY TO ESTIMATE COMBAT EFFECTIVENESS OF TROOPS AND TO DEVELOP METHODS OF DIAGNOSIS, PROGNOSIS, PROPHYLAXIS AND TREATMENT OF RADIATION INJURY. THE PARAMETERS OF INVESTIGATION WERE CLINICAL FINDINGS, HEMATOLOGIC EFFECTS, PROFILE SCORES, DEOXYCYTIDINE EXCRETION IN THE URINE, XANTHURENIC ACID EXCRETION IN THE URINE, CHROMOSOME CHANGES IN LEUCOCYTES, IMMUNOLOGIC STUDIES AND THE USE OF AUTOLOGOUS BONE MARROW. SIX PATIENTS WERE GIVEN FROM 149R TO 231R (100-150 RAD) TOTAL BODY IRRADIATION FROM A CO 60 SOURCE. THE LOWEST HEMATOLOGIC VALUES WERE FOUND 25 TO 35 DAYS AFTER IRRADIATION. DEOXYCYTIDINE WAS FOUND IN INCREASED AMOUNTS IN URINE FROM PATIENTS AFTER TOTAL BODY IRRADIATION. IN RATS LARGE AMOUNTS WERE FOUND IN THE URINE AFTER 500R AND 800R WHOLE BODY IRRADIATION. STUDIES INDICATED THAT THERE MIGHT BE AN IMMUNOLOGIC POST-IRRADIATION ALTERATION IN HUMAN GAMMA GLOBULIN ANTIGENICITY. THE AUTHORS CONCLUDED THAT COMBAT EFFECTIVENESS COULD BE RELATIVELY MAINTAINED WITH AN EXPOSURE UP TO 200 RAD, THOUGH A SECOND EXPOSURE WOULD RESULT IN SIGNIFICANT TROOP INEFFECTIVENESS. THIS IS AN ANNUAL REPORT (PROGRESS REPORT) SENT IN COMPLIANCE FOR CONTINUATION / RECEIPT OF FUNDING OF DA-49-146-XZ-029. (THE FILE ALSO CONTAINS AN ADDITIONAL COPY OF THE REPORT.)