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Title:
ANALYSIS OF ADIPOSE TISSUE AS A KEY TO THE UNDERSTANDING OF MECHANISM OF BODY WEIGHT LOSS IN THE HUMAN (1942-1962)
Subject Terms:
STUDIES WITH HUMAN SUBJECTS
Document Location:
Location - NNSA/NSO Nuclear Testing Archive Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - CIC@NV.DOE.GOV
Document Type:
REPORT
Publication Date:
1962 Jan 01
Declassification Status:
Unknown
Document Pages:
0023
Accession Number:
NV0756761
Originating Research Org.:
UNITED STATES NAVY, DEPARTMENT OF
OpenNet Entry Date:
1999 Jul 13
Description/Abstract:
CHANGES IN THE COMPOSITION OF THE WHOLE BODY AND OF SUBCUTANEOUS ADIPOSE TISSUE HAVE BEEN STUDIED DURING WEIGHT REDUCTION IN 2 HUMN SUBJECTS. THE WHOLE BODY LOST TISSUES RANGING IN DENSITY FROM 0.92-0.96 GMS/ML AT BODY TEMPERATURE, CONSISTING OF 55-85 PERCENT FAT. THE ADIPOSE TISSUE FAT CONTENTS FELL DURING WEIGHT LOSS FROM 80-85 PERCENT TO 65-80 PERCENT OF THE WHOLE TISSUE, OR BY ABOUT 50 PERCENT WHEN RELATED TO THE DRY, DE-FATTED RESIDUE. THE DENSITIES OF FAT DEPOTS INCREASED, THEREFORE, AS A RESULT OF THE EXCESS LOSS OF TISSUE FAT. ADIPOSE TISSUE DENSITIES CALCULATED FROM CHEMICAL COMPOSITION AGREED WELL WITH THE VALUES OBTAINED BY DIRECT DETERMINATION. FROM THESE OBSERVATIONS IT IS CONCLUDED THAT WHILE ADIPOSE TISSUES PROBABLY CONTRIBUTED THE GREATEST PORTION OF THE FAT AND BODY WEIGHT LOSS DURING WEIGHT REDUCTION, OTHER SOFT TISSUES ALSO CONTRIBUTE SIGNIFICANTLY TO THE BODY WEIGHT DECREASE BY LOSING NON-FAT COMPONENTS. ADIPOSE TISSUE COMPONENTS ARE NOT LOST UNIFORMLY DURING BODY WEIGHT LOSS IN THE HUMAN, AS HAD BEEN THOUGHT PREVIOUSLY.


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