National Library of Energy BETA

Sample records for tion administ ration

  1. CLASSIFICdTION CAWXL~ DAm

    Office of Legacy Management (LM)

    CLASSIFICdTION CAWXL DAm NAR 6 1969 For the Atomic EhergY hDh+ ,' ROBERT L JACKSON (' t' for the Chief, Declassification BJx

  2. Administering Work Force Discipline

    Directives, Delegations, and Other Requirements [Office of Management (MA)]

    2015-05-14

    The order provides requirements and responsibilities for administering work force discipline and corrective actions. Supersedes DOE O 3750.1.

  3. Administering Workforce Discipline

    Directives, Delegations, and Other Requirements [Office of Management (MA)]

    2014-10-27

    To provide requirements and responsibilities for administering workforce discipline that includes disciplinary, adverse, and alternative corrective actions in the Department of Energy (DOE).

  4. Administering Nonprofit Energy Efficiency Programs

    Energy.gov [DOE]

    Better Buildings Neighborhood Program Peer Exchange Call: Administering Nonprofit Energy Efficiency Programs, call slides and discussion summary, March 24, 2013.

  5. Rational enzyme redesign

    SciTech Connect

    Ornstein, R.L.

    1994-05-01

    Protein engineering is first a means of elucidating structure-function relations in an enzyme, and second, a means of changing a protein to make it serve a different, but generally related, purpose. In principle, one may change the functional characteristics of an enzyme by altering its substrate specificity, kinetics, optimum range of activity, and chemical mechanism. Obviously one cannot make all possible combinations of amino acid changes for even the smallest enzyme, so the essential question is which changes to make. The intent of rational protein/enzyme redesign is to alter a protein/enzyme in a timely and premeditated fashion. This article provides an outline of the process of rational enzyme redesign.

  6. Process for Administering Distributed Academic Competitions ...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Administering Distributed Academic Competitions The process manages the progression of matches within an academic competition, such as the National Science Bowl. Digital clocks...

  7. NEW - DOE O 333.1, Administering Work Force Discipline

    Directives, Delegations, and Other Requirements [Office of Management (MA)]

    The order provides requirements and responsibilities for administering work force discipline and corrective actions.

  8. Rational Energies LLC | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Minnesota-based development-stage company formed to produce and market renewable diesel made from waste feedstocks. References: Rational Energies LLC1 This article is a...

  9. Secretary of Energy Administers Oath to Three Senior Officials...

    Office of Environmental Management (EM)

    Secretary of Energy Administers Oath to Three Senior Officials September 4, 2007 - 3:16pm Addthis WASHINGTON, DC - Secretary of Energy Samuel W. Bodman today administered the oath ...

  10. Noninvasive Imaging of Administered Progenitor Cells

    SciTech Connect

    Steven R Bergmann, M.D., Ph.D.

    2012-12-03

    -99% pure population of leukocytes. Viability was assessed using Trypan blue histological analysis. We successfully isolated and labeled ~25-30 x 10{sup 7} CD34+ lymphocytes in cytokine mobilized progenitor cell apharesis harvests. Cells were also subjected to a stat gram stain to look for bacterial contamination, stat endotoxin LAL to look for endotoxin contamination, flow cytometry for evaluation of the purity of the cells and 14-day sterility culture. Colony forming assays confirm the capacity of these cells to proliferate and function ex-vivo with CFU-GM values of 26 colonies/ 1 x 10{sup 4} cells plated and 97% viability in cytokine augmented methylcellulose at 10-14 days in CO{sub 2} incubation. We developed a closed-processing system for the product labeling prior to infusion to maintain autologous cell integrity and sterility. Release criteria for the labeled product were documented for viability, cell count and differential, and measured radiolabel. We were successful in labeling the cells with up to 500 uCi/10{sup 8} cells, with viability of >98%. However, due to delays in getting the protocol approved by the FDA, the cells were not infused in humans in this location (although we did successfully use CD34+ cells in humans in a study in Australia). The approach developed should permit labeling of progenitor cells that can be administered to human subjects for tracking. The labeling approach should be useful for all progenitor cell types, although this would need to be verified since different cell lines may have differential radiosensitivity.

  11. DRAFT - DOE O 333.1, Administering Work Force Discipline

    Directives, Delegations, and Other Requirements [Office of Management (MA)]

    To provide requirements and responsibilities for administering workforce discipline that includes disciplinary, adverse, and alternative corrective actions in the Department of Energy (DOE).

  12. Rational design of metal-organic frameworks with anticipated...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Rational design of metal-organic frameworks with anticipated porosities and ... Until now, much progress has been made to rationalize the design and synthesis of MOFs. ...

  13. Title 40 CFR 270: EPA Administered Programs: The Hazardous Waste...

    OpenEI (Open Energy Information) [EERE & EIA]

    270: EPA Administered Programs: The Hazardous Waste Program Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: Title 40 CFR...

  14. Findings from Survey Administered to Weatherization Training Centers

    SciTech Connect

    Conlon, Brian; Tonn, Bruce Edward

    2015-03-01

    This report summarizes results of a survey administered to directors of weatherization training centers that receive funding from the U.S. Department of Energy. The survey presents results related to questions on training offered and future plans.

  15. China rationalizes its renewable energy policy

    SciTech Connect

    Su, Jack H.; Hui, Simone S.; Tsen, Kevin H.

    2010-04-15

    China's over-reliance on thermal power generation, especially coal-fired power stations, is well-documented. While nuclear power continues as an option to coal, China's strides in renewable energy are unprecedented. Recent amendments to the Renewable Energy Law, first promulgated in 2006, attempt to rationalize the regulatory regime governing wind, solar, hydropower and biomass projects in China, currently fraught with inadequate interconnection and tariff shock issues. (author)

  16. CUSSSFIC4TION CMUXLLq

    Office of Legacy Management (LM)

    At the timeofoastiug, the slutemperatame 188 probably scmewbere betaem Baja md 42000. These pieoee were oasttith thend ate; thfities wUbouttUbmmlopen.lng. Cnnone of these pieces ...

  17. The SpallaTion

    Office of Environmental Management (EM)

    ORNL had deep expertise in nuclear science, but it had never built an ... charged hydrogen ion (h - ) beam from 2.5 to 1000 million electron volts, as well as the low energy ...

  18. Administering an epoch initiated for remote memory access

    SciTech Connect

    Blocksome, Michael A; Miller, Douglas R

    2014-03-18

    Methods, systems, and products are disclosed for administering an epoch initiated for remote memory access that include: initiating, by an origin application messaging module on an origin compute node, one or more data transfers to a target compute node for the epoch; initiating, by the origin application messaging module after initiating the data transfers, a closing stage for the epoch, including rejecting any new data transfers after initiating the closing stage for the epoch; determining, by the origin application messaging module, whether the data transfers have completed; and closing, by the origin application messaging module, the epoch if the data transfers have completed.

  19. Administering an epoch initiated for remote memory access

    DOEpatents

    Blocksome, Michael A.; Miller, Douglas R.

    2013-01-01

    Methods, systems, and products are disclosed for administering an epoch initiated for remote memory access that include: initiating, by an origin application messaging module on an origin compute node, one or more data transfers to a target compute node for the epoch; initiating, by the origin application messaging module after initiating the data transfers, a closing stage for the epoch, including rejecting any new data transfers after initiating the closing stage for the epoch; determining, by the origin application messaging module, whether the data transfers have completed; and closing, by the origin application messaging module, the epoch if the data transfers have completed.

  20. Administering an epoch initiated for remote memory access

    DOEpatents

    Blocksome, Michael A; Miller, Douglas R

    2012-10-23

    Methods, systems, and products are disclosed for administering an epoch initiated for remote memory access that include: initiating, by an origin application messaging module on an origin compute node, one or more data transfers to a target compute node for the epoch; initiating, by the origin application messaging module after initiating the data transfers, a closing stage for the epoch, including rejecting any new data transfers after initiating the closing stage for the epoch; determining, by the origin application messaging module, whether the data transfers have completed; and closing, by the origin application messaging module, the epoch if the data transfers have completed.

  1. Rational design and adaptive management of combination therapies...

    Office of Scientific and Technical Information (OSTI)

    therapies for Hepatitis C virus infection Prev Next Title: Rational design and adaptive management of combination therapies for Hepatitis C virus infection Recent ...

  2. Rational Catalyst Design Applied to Development of Advanced Oxidation...

    Energy.gov [DOE] (indexed site)

    More Documents & Publications Overcoming Hydrocarbon Inhibition on Pd-based Diesel Oxidation Catalysts with Rational Catalyst Design Approach Vehicle Technologies Office Merit ...

  3. Administering truncated receive functions in a parallel messaging interface

    DOEpatents

    Archer, Charles J; Blocksome, Michael A; Ratterman, Joseph D; Smith, Brian E

    2014-12-09

    Administering truncated receive functions in a parallel messaging interface (`PMI`) of a parallel computer comprising a plurality of compute nodes coupled for data communications through the PMI and through a data communications network, including: sending, through the PMI on a source compute node, a quantity of data from the source compute node to a destination compute node; specifying, by an application on the destination compute node, a portion of the quantity of data to be received by the application on the destination compute node and a portion of the quantity of data to be discarded; receiving, by the PMI on the destination compute node, all of the quantity of data; providing, by the PMI on the destination compute node to the application on the destination compute node, only the portion of the quantity of data to be received by the application; and discarding, by the PMI on the destination compute node, the portion of the quantity of data to be discarded.

  4. WPN 09-1B: Grant Guidance to Administer the American Recovery...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    9-1B: Grant Guidance to Administer the American Recovery and Reinvestment Act of 2009 Funding WPN 09-1B: Grant Guidance to Administer the American Recovery and Reinvestment Act of ...

  5. Rational Design of Artificial Metal-Based Enzymes | Center for...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Rational Design of Artificial Metal-Based Enzymes 17 Mar 2014 Giovanna Ghirlanda is one of ... of Subtask 3 with an objective to design and optimize artificial catalysts for ...

  6. Implementing Rational Surface Locations Measured From Thomson Scattering Into

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Implementing Rational Surface Locations Measured From Thomson Scattering Into MSTfit by Curtis A. Johnson Senior Thesis (Physics) at the University of Wisconsin-Madison 2014 i Abstract Measurements of rational surface (RS) locations in the Madison Symmetric Torus as measured by Thomson Scattering (TS) have been implemented in the equilibrium reconstruction program MSTfit. Possible correlated errors between diagnostics show a small impact on the equilibrium reconstruction done by MSTfit. TS RS

  7. Rationality Validation of a Layered Decision Model for Network Defense

    SciTech Connect

    Wei, Huaqiang; Alves-Foss, James; Zhang, Du; Frincke, Deb

    2007-08-31

    We propose a cost-effective network defense strategy built on three key: three decision layers: security policies, defense strategies, and real-time defense tactics for countering immediate threats. A layered decision model (LDM) can be used to capture this decision process. The LDM helps decision-makers gain insight into the hierarchical relationships among inter-connected entities and decision types, and supports the selection of cost-effective defense mechanisms to safeguard computer networks. To be effective as a business tool, it is first necessary to validate the rationality of model before applying it to real-world business cases. This paper describes our efforts in validating the LDM rationality through simulation.

  8. WPN 09-1B: Grant Guidance to Administer the American Recovery and

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Reinvestment Act of 2009 Funding | Department of Energy 9-1B: Grant Guidance to Administer the American Recovery and Reinvestment Act of 2009 Funding WPN 09-1B: Grant Guidance to Administer the American Recovery and Reinvestment Act of 2009 Funding Archived 09/30/15, ARRA Completion To issue grant guidance and management information for accessing funding under the American Recovery and Reinvestment Act of 2009 (Recovery Act). This guidance should be used in conjunction with Weatherization

  9. Overcoming Hydrocarbon Inhibition on Pd-based Diesel Oxidation Catalysts with Rational Catalyst Design Approach

    Energy.gov [DOE]

    Discusses results of a project focused on overcoming hydrocarbon inhibition on Pd-based diesel oxidation catalysts by using a rational catalyst design approach.

  10. U-154: IBM Rational ClearQuest ActiveX Control Buffer Overflow Vulnerability

    Energy.gov [DOE]

    A vulnerability was reported in IBM Rational ClearQuest. A remote user can cause arbitrary code to be executed on the target user's system.

  11. LANL/LANS 2017 BCBSNM-Administered Medical Programs: ACTIVE EMPLOYEES & NON-MEDICARE RETIREES

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    7) LANL/LANS 2017 BCBSNM-Administered Medical Programs: ACTIVE EMPLOYEES & NON-MEDICARE RETIREES At-A-Glance: Comparing the 2017 PPO & HDHP Medical Programs Medical Program Benefit Comparison PPO Benefits & Cost Sharing HDHP + HSA Benefits & Cost-Sharing Preferred Provider (In-Network) Nonpreferred Provider (Out-of-Network) Preferred Provider (In-Network) Nonpreferred Provider (Out-of-Network) Calendar Year Deductible - All services are subject to deductible unless otherwise

  12. Rational Solutions for Challenges of the New Mellennium

    SciTech Connect

    Gover, J.; Guray, P.G.

    1998-08-01

    We have reviewed ten major public problems challenging our Nation as it enters the new millennium. These are defense, healthcare costs, education, aging population, energy and environment, crime, low productivity growth services, income distribution, regulations, and infrastructure. These problems share several features. First, each is so large, if it were soIved; it would have major impact on the U.S. economy. Second, each is resident in a socioeconomic system containing non-linear feedback loops and an adaptive human element. Third, each can only be solved by our political system, yet these problems are not responsive to piecemeal problem solving, the approach traditionally used by policy makers. However, unless each problem is addressed in the context of the system in which it resides, the solution maybe worse than the problem. Our political system is immersed in reams of disconnected, unintelligible information skewed by various special interests to suggest policies favoring their particular needs. Help is needed, if rational solutions that serve public interests are to be forged for these ten probIems, The simulation and modeIing tools of physical scientists, engineers, economists, social scientists, public policy experts, and others, bolstered by the recent explosive growth in massively parallel computing power, must be blended together to synthesize models of the complex systems in which these problems are resident. These models must simulate the seemingly chaotic human element inherent in these systems and support policymakers in making informed decKlons about the future. We propose altering the policy development process by incorporating more modeling, simulation and analysis to bring about a revolution in policy making that takes advantage of the revolution in engineering emerging from simulation and modeling. While we recommend major research efforts to address each of these problems, we also observe these to be very complex, highly interdependent, multi

  13. Regulatory analysis on criteria for the release of patients administered radioactive material

    SciTech Connect

    Schneider, S.; McGuire, S.A.; Behling, U.H.; Behling, K.; Goldin, D.

    1994-05-01

    The Nuclear Regulatory Commission (NRC) has received two petitions to amend its regulations in 10 CFR Parts 20 and 35 as they apply to doses received by members of the public exposed to patients released from a hospital after they have been administered radioactive material. While the two petitions are not identical they both request that the NRC establish a dose limit of 5 millisieverts (0.5 rem) per year for individuals exposed to patients who have been administered radioactive materials. This Regulatory Analysis evaluates three alternatives. Alternative 1 is for the NRC to amend its patient release criteria in 10 CFR 35.75 to use the more stringent dose limit of 1 millisievert per year in 10 CFR 20.1301(a) for its patient release criteria. Alternative 2 is for the NRC to continue using the existing patient release criteria in 10 CFR 35.75 of 1,110 megabecquerels of activity or a dose rate at one meter from the patient of 0.05 millisievert per hour. Alternative 3 is for the NRC to amend the patient release criteria in 10 CFR 35.75 to specify a dose limit of 5 millisieverts for patient release. The evaluation indicates that Alternative 1 would cause a prohibitively large increase in the national health care cost from retaining patients in a hospital longer and would cause significant personal and psychological costs to patients and their families. The choice of Alternatives 2 or 3 would affect only thyroid cancer patients treated with iodine-131. For those patients, Alternative 3 would result in less hospitalization than Alternative 2. Alternative 3 has a potential decrease in national health care cost of $30,000,000 per year but would increase the potential collective dose from released therapy patients by about 2,700 person-rem per year, mainly to family members.

  14. In vivo uptake and acute immune response to orally administered chitosan and PEG coated PLGA nanoparticles

    SciTech Connect

    Semete, B.; Booysen, L.I.J.; Kalombo, L.; Venter, J.D.; Katata, L.; Ramalapa, B.; Verschoor, J.A.; Swai, H.

    2010-12-01

    Nanoparticulate drug delivery systems offer great promise in addressing challenges of drug toxicity, poor bioavailability and non-specificity for a number of drugs. Much progress has been reported for nano drug delivery systems for intravenous administration, however very little is known about the effects of orally administered nanoparticles. Furthermore, the development of nanoparticulate systems necessitates a thorough understanding of the biological response post exposure. This study aimed to elucidate the in vivo uptake of chitosan and polyethylene glycol (PEG) coated Poly, DL, lactic-co-glycolic Acid (PLGA) nanoparticles and the immunological response within 24 h of oral and peritoneal administration. These PLGA nanoparticles were administered orally and peritoneally to female Balb/C mice, they were taken up by macrophages of the peritoneum. When these particles were fluorescently labelled, intracellular localisation was observed. The expression of pro-inflammatory cytokines IL-2, IL-6, IL-12p70 and TNF-{alpha} in plasma and peritoneal lavage was found to remain at low concentration in PLGA nanoparticles treated mice as well as ZnO nanoparticles during the 24 hour period. However, these were significantly increased in lipopolysaccharide (LPS) treated mice. Of these pro-inflammatory cytokines, IL-6 and IL-12p70 were produced at the highest concentration in the positive control group. The anti-inflammatory cytokines IL-10 and chemokines INF-{gamma}, IL-4, IL-5 remained at normal levels in PLGA treated mice. IL-10 and INF-{gamma} were significantly increased in LPS treated mice. MCP-1 was found to be significantly produced in all groups in the first hours, except the saline treated mice. These results provide the first report to detail the induction of cytokine production by PLGA nanoparticles engineered for oral applications.

  15. The use of artificially intelligent agents with bounded rationality in the study of economic markets

    SciTech Connect

    Rajan, V.; Slagle, J.R.

    1996-12-31

    The concepts of {open_quote}knowledge{close_quote} and {open_quote}rationality{close_quote} are of central importance to fields of science that are interested in human behavior and learning, such as artificial intelligence, economics, and psychology. The similarity between artificial intelligence and economics - both are concerned with intelligent thought, rational behavior, and the use and acquisition of knowledge - has led to the use of economic models as a paradigm for solving problems in distributed artificial intelligence (DAI) and multi agent systems (MAS). What we propose is the opposite; the use of artificial intelligence in the study of economic markets. Over the centuries various theories of market behavior have been advanced. The prevailing theory holds that an asset`s current price converges to the risk adjusted value of the rationally expected dividend stream. While this rational expectations model holds in equilibrium or near-equilibrium conditions, it does not sufficiently explain conditions of market disequilibrium. An example of market disequilibrium is the phenomenon of a speculative bubble. We present an example of using artificially intelligent agents with bounded rationality in the study of speculative bubbles.

  16. Regulatory analysis on criteria for the release of patients administered radioactive material. Final report

    SciTech Connect

    Schneider, S.; McGuire, S.A.

    1997-02-01

    This regulatory analysis was developed to respond to three petitions for rulemaking to amend 10 CFR parts 20 and 35 regarding release of patients administered radioactive material. The petitions requested revision of these regulations to remove the ambiguity that existed between the 1-millisievert (0.1-rem) total effective dose equivalent (TEDE) public dose limit in Part 20, adopted in 1991, and the activity-based release limit in 10 CFR 35.75 that, in some instances, would permit release of individuals in excess of the current public dose limit. Three alternatives for resolution of the petitions were evaluated. Under Alternative 1, NRC would amend its patient release criteria in 10 CFR 35.75 to match the annual public dose limit in Part 20 of 1 millisievert (0.1 rem) TEDE. Alternative 2 would maintain the status quo of using the activity-based release criteria currently found in 10 CFR 35.75. Under Alternative 3, the NRC would revise the release criteria in 10 CFR 35.75 to specify a dose limit of 5 millisieverts (0.5 rem) TEDE.

  17. T-615: IBM Rational System Architect ActiveBar ActiveX Control Lets Remote Users Execute Arbitrary Code

    Energy.gov [DOE]

    There is a high risk security vulnerability with the ActiveBar ActiveX controls used by IBM Rational System Architect.

  18. U-007: IBM Rational AppScan Import/Load Function Flaws Let Remote Users Execute Arbitrary Code

    Energy.gov [DOE]

    Two vulnerabilities were reported in IBM Rational AppScan. A remote user can cause arbitrary code to be executed on the target user's system.

  19. UTICA 4, NEW YORK COFIPOR~TION

    Office of Legacy Management (LM)

    H. J. Zmjian, GE", of the ncmbers of our orzaniza- has a "Q" cl:arance and our President is rcqueoting an 'L" clearance for some of us. -'n would appreciate it very much if you ...

  20. Rational extension and Jacobi-type X{sub m} solutions of a quantum nonlinear oscillator

    SciTech Connect

    Schulze-Halberg, Axel; Roy, Barnana

    2013-12-15

    We construct a rational extension of a recently studied nonlinear quantum oscillator model. Our extended model is shown to retain exact solvability, admitting a discrete spectrum and corresponding closed-form solutions that are expressed through Jacobi-type X{sub m} exceptional orthogonal polynomials.

  1. Utilizing interfaces: One-step forward for rational design of heterogeneous catalysts

    SciTech Connect

    Kim H. Y.

    2013-06-20

    As far as heterogeneous catalysts are a composite material, physicochemical properties of the interfaces between individual components should be extensively studied for rational design of catalysts with desired properties. Here, I will present recent computational achievements in following three heterogeneous catalysts where the interface between composing materials plays a critical role

  2. Measured dose rate constant from oncology patients administered 18F for positron emission tomography

    SciTech Connect

    Quinn, Brian; Holahan, Brian; Aime, Jean; Humm, John; St Germain, Jean; Dauer, Lawrence T.

    2012-10-15

    Purpose: Patient exposure rate measurements verify published patient dose rate data and characterize dose rates near 2-18-fluorodeoxyglucose ({sup 18}F-FDG) patients. A specific dose rate constant based on patient exposure rate measurements is a convenient quantity that can be applied to the desired distance, injection activity, and time postinjection to obtain an accurate calculation of cumulative external radiation dose. This study reports exposure rates measured at various locations near positron emission tomography (PET) {sup 18}F-FDG patients prior to PET scanning. These measurements are normalized for the amount of administered activity, measurement distance, and time postinjection and are compared with other published data. Methods: Exposure rates were measured using a calibrated ionization chamber at various body locations from 152 adult oncology patients postvoid after a mean uptake time of 76 min following injection with a mean activity of 490 MBq {sup 18}F-FDG. Data were obtained at nine measurement locations for each patient: three near the head, four near the chest, and two near the feet. Results: On contact with, 30 cm superior to and 30 cm lateral to the head, the mean (75th percentile) dose rates per unit injected activity at 60 min postinjection were 0.482 (0.511), 0.135 (0.155), and 0.193 (0.223) {mu}Sv/MBq h, respectively. On contact with, 30 cm anterior to, 30 cm lateral to and 1 m anterior to the chest, the mean (75th percentile) dose rates per unit injected activity at 60 min postinjection were 0.623 (0.709), 0.254 (0.283), 0.190 (0.218), and 0.067 (0.081) {mu}Sv/MBq h respectively. 30 cm inferior and 30 cm lateral to the feet, the mean (75th percentile) dose rates per unit injected activity at 60 min postinjection were 0.024 (0.022) and 0.039 (0.044) {mu}Sv/MBq h, respectively. Conclusions: The measurements for this study support the use of 0.092 {mu}Sv m{sup 2}/MBq h as a reasonable representation of the dose rate anterior from the chest of

  3. Rational Design of Rhodium Complexes Featuring κ4-N,N,N,N- and

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    κ5-N,N,N,P,P-Bis(imino)pyridine Ligands Rational Design of Rhodium Complexes Featuring κ4-N,N,N,N- and κ5-N,N,N,P,P-Bis(imino)pyridine Ligands Authors: Ben-Daat, H., Hall, G.B., Groy, T.L., and Trovitch, R.J Title: Rational Design of Rhodium Complexes Featuring κ4-N,N,N,N- and κ5-N,N,N,P,P-Bis(imino)pyridine Ligands Source: European Journal of Inorganic Chemistry Year: 2013 Volume: 25 Pages: 4430-4442 ABSTRACT: The addition of aminoalkyl-substituted 2,6-bis(imino)pyridine (or pyridine

  4. Verification of the ideal magnetohydrodynamic response at rational surfaces in the VMEC code

    SciTech Connect

    Lazerson, Samuel A.; Loizu, Joaquim; Hirshman, Steven; Hudson, Stuart R.

    2016-01-01

    The VMEC nonlinear ideal MHD equilibrium code [S. P. Hirshman and J. C. Whitson, Phys. Fluids 26, 3553 (1983)] is compared against analytic linear ideal MHD theory in a screw-pinch-like configuration. The focus of such analysis is to verify the ideal MHD response at magnetic surfaces which possess magnetic transform (ι) which is resonant with spectral values of the perturbed boundary harmonics. A large aspect ratio circular cross section zero-beta equilibrium is considered. This equilibrium possess a rational surface with safety factor q = 2 at a normalized flux value of 0.5. A small resonant boundary perturbation is introduced, exciting a response at the resonant rational surface. The code is found to capture the plasma response as predicted by a newly developed analytic theory that ensures the existence of nested flux surfaces by allowing for a jump in rotational transform (ι=1/qι=1/q). The VMEC code satisfactorily reproduces these theoretical results without the necessity of an explicit transform discontinuity (ΔιΔι) at the rational surface. It is found that the response across the rational surfaces depends upon both radial grid resolution and local shear (dι/dΦdι/dΦ, where ι is the rotational transform and ΦΦ the enclosed toroidal flux). Calculations of an implicit ΔιΔι suggest that it does not arise due to numerical artifacts (attributed to radial finite differences in VMEC) or existence conditions for flux surfaces as predicted by linear theory (minimum values of ΔιΔι). Scans of the rotational transform profile indicate that for experimentally relevant levels of transform shear the response becomes increasing localised. Careful examination of a large experimental tokamak equilibrium, with applied resonant fields, indicates that this shielding response is present, suggesting the phenomena is not limited to this verification exercise.

  5. Design Rational

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Compression Function Performance......This will allow "plug and play" with many of the data formatting ... parts of SANDstorm account for its high speed potential. ...

  6. An efficient implementation of the Chebyshev Rational Approximation Method (CRAM) for solving the burnup equations

    SciTech Connect

    Pusa, M.; Leppaenen, J.

    2012-07-01

    The Chebyshev Rational Approximation Method (CRAM) has been recently introduced by the authors for solving the burnup equations with excellent results. This method has been shown to be capable of simultaneously solving an entire burnup system with thousands of nuclides both accurately and efficiently. The method was prompted by an analysis of the spectral properties of burnup matrices and it can be characterized as the best rational approximation on the negative real axis. The coefficients of the rational approximation are fixed and have been reported for various approximation orders. In addition to these coefficients, implementing the method only requires a linear solver. This paper describes an efficient method for solving the linear systems associated with the CRAM approximation. The introduced direct method is based on sparse Gaussian elimination where the sparsity pattern of the resulting upper triangular matrix is determined before the numerical elimination phase. The stability of the proposed Gaussian elimination method is discussed based on considering the numerical properties of burnup matrices. Suitable algorithms are presented for computing the symbolic factorization and numerical elimination in order to facilitate the implementation of CRAM and its adoption into routine use. The accuracy and efficiency of the described technique are demonstrated by computing the CRAM approximations for a large test case with over 1600 nuclides. (authors)

  7. Method for loading lipsomes with ionizable phosphorylated hydrophobic compounds, pharmaceutical preparations and a method for administering the preparations

    DOEpatents

    Mehlhorn, R.J.

    1998-10-27

    A method of entrapping ionizable compounds, preferably phosphorylated hydrophobic compounds, into liposomes having transmembrane gradients is disclosed. The procedures involve forming liposomes in an acidic medium or a basic medium, adding to the acidic medium a cationic compound or to the basic medium an anionic compound and then adding a base to the cationic-containing medium or an acid to the anionic-containing medium, thereby inducing the ionizable compound into the liposomes` internal aqueous phase. The compound-entrapped liposomes prepared in accordance with the disclosed methods may be used as pharmaceutical preparations. Methods of administering such pharmaceutical preparations are also disclosed. 2 figs.

  8. Method for loading lipsomes with ionizable phosphorylated hydrophobic compounds, pharmaceutical preparations and a method for administering the preparations

    DOEpatents

    Mehlhorn, Rolf Joachim

    1998-10-27

    A method of entrapping ionizable compounds, preferably phosphorylated hydrophobic compounds, into liposomes having transmembrane gradients is disclosed. The procedures involve forming liposomes in an acidic medium or a basic medium, adding to the acidic medium a cationic compound or to the basic medium an anionic compound and then adding a base to the cationic-containing medium or an acid to the anionic-containing medium, thereby inducing the ionizable compound into the liposomes' internal aqueous phase. The compound-entrapped liposomes prepared in accordance with the disclosed methods may be used as pharmaceutical preparations. Methods of administering such pharmaceutical preparations are also disclosed.

  9. A rational minor actinide (MA) recycling concept based on innovative oxide fuel with high AM content

    SciTech Connect

    Tanaka, Kenya; Sato, Isamu; Ishii, Tetsuya; Yoshimochi, Hiroshi; Asaga, Takeo; Kurosaki, Ken

    2007-07-01

    A rational MA recycle concept based on high Am content fuel has been proposed. A design study of an Am- MOX fabrication plant, which is a key facility for the MA recycle concept, has been done and the facility concept was clarified from the viewpoint of basic process viability. Preliminary cost estimation suggested that the total construction cost of the MA recycle facilities including Am-MOX, Np-MOX and MA recovery could be comparable with that of the large scale LWR-MOX fabrication plant required for plutonium in LWR fuel cycle. (authors)

  10. Accuracy considerations for Chebyshev rational approximation method (CRAM) in Burnup calculations

    SciTech Connect

    Pusa, M.

    2013-07-01

    The burnup equations can in principle be solved by computing the exponential of the burnup matrix. However, due to the difficult numerical characteristics of burnup matrices, the problem is extremely stiff and the matrix exponential solution has previously been considered infeasible for an entire burnup system containing over a thousand nuclides. It was recently discovered by the author that the eigenvalues of burnup matrices are generally located near the negative real axis, which prompted introducing the Chebyshev rational approximation method (CRAM) for solving the burnup equations. CRAM can be characterized as the best rational approximation on the negative real axis and it has been shown to be capable of simultaneously solving an entire burnup system both accurately and efficiently. In this paper, the accuracy of CRAM is further studied in the context of burnup equations. The approximation error is analyzed based on the eigenvalue decomposition of the burnup matrix. It is deduced that the relative accuracy of CRAM may be compromised if a nuclide concentration diminishes significantly during the considered time step. Numerical results are presented for two test cases, the first one representing a small burnup system with 36 nuclides and the second one a full a decay system with 1531 nuclides. (authors)

  11. Rational Conversion of Affinity Reagents into Label-Free Sensors for Peptide Motifs by Designed Allostery

    SciTech Connect

    Huang, Jin; Koide, Shohei

    2010-05-25

    Optical biosensors for short peptide motifs, an important class of biomarkers, have been developed based on 'affinity clamps', a new class of recombinant affinity reagents. Affinity clamps are engineered by linking a peptide-binding domain and an antibody mimic domain based on the fibronectin type III scaffold, followed by optimization of the interface between the two. This two-domain architecture allows for the design of allosteric coupling of peptide binding to fluorescence energy transfer between two fluorescent proteins attached to the affinity clamp. Coupled with high affinity and specificity of the underlying affinity clamps and rationally designed mutants with different sensitivity, peptide concentrations in crude cell lysate were determined with a low nanomolar detection limit and over 3 orders of magnitude. Because diverse affinity clamps can be engineered, our strategy provides a general platform to generate a repertoire of genetically encoded, label-free sensors for peptide motifs.

  12. Generalized Information Architecture for Managing Requirements in IBM?s Rational DOORS(r) Application.

    SciTech Connect

    Aragon, Kathryn M.; Eaton, Shelley M.; McCornack, Marjorie T.; Shannon, Sharon A.

    2014-12-01

    When a requirements engineering effort fails to meet expectations, often times the requirements management tool is blamed. Working with numerous project teams at Sandia National Laboratories over the last fifteen years has shown us that the tool is rarely the culprit; usually it is the lack of a viable information architecture with well- designed processes to support requirements engineering. This document illustrates design concepts with rationale, as well as a proven information architecture to structure and manage information in support of requirements engineering activities for any size or type of project. This generalized information architecture is specific to IBM's Rational DOORS (Dynamic Object Oriented Requirements System) software application, which is the requirements management tool in Sandia's CEE (Common Engineering Environment). This generalized information architecture can be used as presented or as a foundation for designing a tailored information architecture for project-specific needs. It may also be tailored for another software tool. Version 1.0 4 November 201

  13. Rational design and adaptive management of combination therapies for Hepatitis C virus infection

    DOE PAGES [OSTI]

    Ke, Ruian; Loverdo, Claude; Qi, Hangfei; Sun, Ren; Lloyd-Smith, James O.; Kouyos, Roger Dimitri

    2015-06-30

    Recent discoveries of direct acting antivirals against Hepatitis C virus (HCV) have raised hopes of effective treatment via combination therapies. Yet rapid evolution and high diversity of HCV populations, combined with the reality of suboptimal treatment adherence, make drug resistance a clinical and public health concern. We develop a general model incorporating viral dynamics and pharmacokinetics/ pharmacodynamics to assess how suboptimal adherence affects resistance development and clinical outcomes. We derive design principles and adaptive treatment strategies, identifying a high-risk period when missing doses is particularly risky for de novo resistance, and quantifying the number of additional doses needed to compensatemore » when doses are missed. Using data from large-scale resistance assays, we demonstrate that the risk of resistance can be reduced substantially by applying these principles to a combination therapy of daclatasvir and asunaprevir. By providing a mechanistic framework to link patient characteristics to the risk of resistance, these findings show the potential of rational treatment design.« less

  14. Tuning calcite morphology and growth acceleration by a rational design of highly stable protein-mimetics

    SciTech Connect

    Chen, Chunlong; Qi, Jiahui; Tao, Jinhui; Zuckermann, Ronald; De Yoreo, James J.

    2014-09-05

    In nature, proteins play a significant role in biomineral formation. One of the ultimate goals of bioinspired materials science is to develop highly stable synthetic molecules that mimic the function of these natural proteins by controlling crystal formation. Here, we demonstrate that both the morphology and the degree of acceleration or inhibition observed during growth of calcite in the presence of peptoids can be rationally tuned by balancing the electrostatic interactions (EI) and hydrophobic interactions (HI), with HI playing the dominant role. While either strong EI or HI inhibit growth and suppress (104) face expression, correlations between peptoid-crystal binding energies and observed changes in calcite growth indicate moderate EI allow peptoids to weakly adsorb while moderate HI cause disruption of surface-adsorbed water layers, leading to growth acceleration with retained expression of (104) faces. This study provides fundamental principles for designing peptoids as crystallization promoters, and offers a straightforward screening method based on macroscopic crystal morphology. Because peptoids are sequence-specific, highly stable, and easily synthesized, peptoid-enhanced crystallization offers a broad range of potential applications.

  15. Structure of the Escherichia coli Phosphonate Binding Protein PhnD and Rationally Optimized Phosphonate Biosensors

    SciTech Connect

    Alicea, Ismael; Marvin, Jonathan S.; Miklos, Aleksandr E.; Ellington, Andrew D.; Looger, Loren L.; Schreiter, Eric R.

    2012-09-17

    The phnD gene of Escherichia coli encodes the periplasmic binding protein of the phosphonate (Pn) uptake and utilization pathway. We have crystallized and determined structures of E. coli PhnD (EcPhnD) in the absence of ligand and in complex with the environmentally abundant 2-aminoethylphosphonate (2AEP). Similar to other bacterial periplasmic binding proteins, 2AEP binds near the center of mass of EcPhnD in a cleft formed between two lobes. Comparison of the open, unliganded structure with the closed 2AEP-bound structure shows that the two lobes pivot around a hinge by {approx}70{sup o} between the two states. Extensive hydrogen bonding and electrostatic interactions stabilize 2AEP, which binds to EcPhnD with low nanomolar affinity. These structures provide insight into Pn uptake by bacteria and facilitated the rational design of high signal-to-noise Pn biosensors based on both coupled small-molecule dyes and autocatalytic fluorescent proteins.

  16. Surface Termination of M1 Phase and Rational Design of Propane Ammoxidation Catalysts

    SciTech Connect

    Guliants, Vadim

    2015-02-16

    This final report describes major accomplishments in this research project which has demonstrated that the M1 phase is the only crystalline phase required for propane ammoxidation to acrylonitrile and that a surface monolayer terminating the ab planes of the M1 phase is responsible for their activity and selectivity in this reaction. Fundamental studies of the topmost surface chemistry and mechanism of propane ammoxidation over the Mo-V-(Te,Sb)-(Nb,Ta)-O M1 and M2 phases resulted in the development of quantitative understanding of the surface molecular structure – reactivity relationships for this unique catalytic system. These oxides possess unique catalytic properties among mixed metal oxides, because they selectively catalyze three alkane transformation reactions, namely propane ammoxidation to acrylonitrile, propane oxidation to acrylic acid and ethane oxidative dehydrogenation, all of considerable economic significance. Therefore, the larger goal of this research was to expand this catalysis to other alkanes of commercial interest, and more broadly, demonstrate successful approaches to rational design of improved catalysts that can be applied to other selective (amm)oxidation processes.

  17. Rational design and adaptive management of combination therapies for Hepatitis C virus infection

    SciTech Connect

    Ke, Ruian; Loverdo, Claude; Qi, Hangfei; Sun, Ren; Lloyd-Smith, James O.; Kouyos, Roger Dimitri

    2015-06-30

    Recent discoveries of direct acting antivirals against Hepatitis C virus (HCV) have raised hopes of effective treatment via combination therapies. Yet rapid evolution and high diversity of HCV populations, combined with the reality of suboptimal treatment adherence, make drug resistance a clinical and public health concern. We develop a general model incorporating viral dynamics and pharmacokinetics/ pharmacodynamics to assess how suboptimal adherence affects resistance development and clinical outcomes. We derive design principles and adaptive treatment strategies, identifying a high-risk period when missing doses is particularly risky for de novo resistance, and quantifying the number of additional doses needed to compensate when doses are missed. Using data from large-scale resistance assays, we demonstrate that the risk of resistance can be reduced substantially by applying these principles to a combination therapy of daclatasvir and asunaprevir. By providing a mechanistic framework to link patient characteristics to the risk of resistance, these findings show the potential of rational treatment design.

  18. Projects Funded by the American Recovery and Reinvestment Act of 2009 and Administered by the Office of Energy Efficiency and Renewable Energy (EERE) Notice

    Energy.gov [DOE]

    U.S. Department of Energy (DOE) National Environmental Policy Act (NEPA) guidelines for states and U.S. territories sponsoring energy efficiency and renewable energy projects funded by the 2009 Recovery Act and administered through the DOE State Energy Program (SEP).

  19. IV Administered Gadodiamide Enters the Lumen of the Prostatic Glands: X-Ray Fluorescence Microscopy Examination of a Mouse Model

    SciTech Connect

    Mustafi, Devkumar; Gleber, Sophie-Charlotte; Ward, Jesse; Dougherty, Urszula; Zamora, Marta; Markiewicz, Erica; Binder, David C.; Antic, Tatjana; Vogt, Stefan; Karczmar, Gregory S.; Oto, Aytekin

    2015-09-01

    In our objective, we descibe how dynamic contrast-enhanced MRI (DCE-MRI) has become a standard component of multiparametric protocols for MRI examination of the prostate, and its use is incorporated into current guidelines for prostate MRI examination. Analysis of DCE-MRI data for the prostate is usually based on the distribution of gadolinium-based agents, such as gadodiamide, into two well-mixed compartments, and it assumes that gadodiamide does not enter into the glandular lumen. However, this assumption has not been directly tested. The purpose of this study was to use x-ray fluorescence microscopy (XFM) imaging in situ to measure the concentration of gadodiamide in the epithelia and lumens of the prostate of healthy mice after IV injection of the contrast agent. For our materials and methods, six C57Bl6 male mice (age, 28 weeks) were sacrificed 10 minutes after IV injection of gadodiamide (0.13 mmol/kg), and three mice were sacrificed after saline injection. Prostate tissue samples obtained from each mouse were harvested and frozen; 7-μm-thick slices were sectioned for XFM imaging, and adjacent 5-μm-thick slices were sectioned for H and E staining. Elemental concentrations were determined from XFM images. Our results show mean (± SD) baseline concentration of gadolinium of 0.01 ± 0.01 mM was determined from XFM measurements of prostatic tissue samples when no gadodiamide was administered, and it was used to determine the measurement error. When gadodiamide was added, the mean concentrations of gadolinium in the epithelia and lumens in 32 prostatic glands from six mice were 1.00 ± 0.13 and 0.36 ± 0.09 mM, respectively. In conclusion, our data suggest that IV administration of gadodiamide results in uptake of contrast agent by the glandular lumens of the mouse prostate. We were able to quantitatively determine gadodiamide distributions in mouse prostatic epithelia and lumens.

  20. IV Administered Gadodiamide Enters the Lumen of the Prostatic Glands: X-Ray Fluorescence Microscopy Examination of a Mouse Model

    DOE PAGES [OSTI]

    Mustafi, Devkumar; Gleber, Sophie-Charlotte; Ward, Jesse; Dougherty, Urszula; Zamora, Marta; Markiewicz, Erica; Binder, David C.; Antic, Tatjana; Vogt, Stefan; Karczmar, Gregory S.; et al

    2015-09-01

    In our objective, we descibe how dynamic contrast-enhanced MRI (DCE-MRI) has become a standard component of multiparametric protocols for MRI examination of the prostate, and its use is incorporated into current guidelines for prostate MRI examination. Analysis of DCE-MRI data for the prostate is usually based on the distribution of gadolinium-based agents, such as gadodiamide, into two well-mixed compartments, and it assumes that gadodiamide does not enter into the glandular lumen. However, this assumption has not been directly tested. The purpose of this study was to use x-ray fluorescence microscopy (XFM) imaging in situ to measure the concentration of gadodiamidemore » in the epithelia and lumens of the prostate of healthy mice after IV injection of the contrast agent. For our materials and methods, six C57Bl6 male mice (age, 28 weeks) were sacrificed 10 minutes after IV injection of gadodiamide (0.13 mmol/kg), and three mice were sacrificed after saline injection. Prostate tissue samples obtained from each mouse were harvested and frozen; 7-μm-thick slices were sectioned for XFM imaging, and adjacent 5-μm-thick slices were sectioned for H and E staining. Elemental concentrations were determined from XFM images. Our results show mean (± SD) baseline concentration of gadolinium of 0.01 ± 0.01 mM was determined from XFM measurements of prostatic tissue samples when no gadodiamide was administered, and it was used to determine the measurement error. When gadodiamide was added, the mean concentrations of gadolinium in the epithelia and lumens in 32 prostatic glands from six mice were 1.00 ± 0.13 and 0.36 ± 0.09 mM, respectively. In conclusion, our data suggest that IV administration of gadodiamide results in uptake of contrast agent by the glandular lumens of the mouse prostate. We were able to quantitatively determine gadodiamide distributions in mouse prostatic epithelia and lumens.« less

  1. On using rational enzyme redesign to improve enzyme-mediated microbial dehalogenation of recalcitrant substances in deep-subsurface environments

    SciTech Connect

    Ornstein, R.L.

    1993-06-01

    Heavily halogenated hydrocarbons are one of the most prevalent classes of man-made recalcitrant environmental contaminants and often make their way into subsurface environments. Biodegradation of heavily chlorinated compounds in the deep subsurface often occurs at extremely slow rates because native enzymes of indigenous microbes are unable to efficiently metabolize such synthetic substances. Cost-effective engineering solutions do not exist for dealing with disperse and recalcitrant pollutants in the deep subsurface (i.e., ground water, soils, and sediments). Timely biodegradation of heavily chlorinated compounds in the deep subsurface may be best accomplished by rational redesign of appropriate enzymes that enhance the ability of indigenous microbes to metabolize these substances. The isozyme family cytochromes P450 are catalytically very robust and are found in all aerobic life forms and may be active in may anaerobes as well. The author is attempting to demonstrate proof-of-principle rational enzyme redesign of cytochromes P450 to enhance biodehalogenation.

  2. Zinc content of selected tissues and taste perception in rats fed zinc deficient and zinc adequate rations

    SciTech Connect

    Boeckner, L.S.; Kies, C.

    1986-03-05

    The objective of the study was to determine the effects of feeding zinc sufficient and zinc deficient rations on taste sensitivity and zinc contents of selected organs in rats. The 36 Sprague-Dawley male weanling rats were divided into 2 groups and fed zinc deficient or zinc adequate rations. The animals were subjected to 4 trial periods in which a choice of deionized distilled water or a solution of quinine sulfate at 1.28 x 10/sup -6/ was given. A randomized schedule for rat sacrifice was used. No differences were found between zinc deficient and zinc adequate rats in taste preference aversion scores for quinine sulfate in the first three trial periods; however, in the last trial period rats in the zinc sufficient group drank somewhat less water containing quinine sulfate as a percentage of total water consumption than did rats fed the zinc deficient ration. Significantly higher zinc contents of kidney, brain and parotid salivary glands were seen in zinc adequate rats compared to zinc deficient rats at the end of the study. However, liver and tongue zinc levels were lower for both groups at the close of the study than were those of rats sacrificed at the beginning of the study.

  3. Dosimetric results in treatments of neuroblastoma and neuroendocrine tumors with {sup 131}I-metaiodobenzylguanidine with implications for the activity to administer

    SciTech Connect

    Mínguez, Pablo; Genollá, José; Guayambuco, Sonía; Delgado, Alejandro; Fombellida, José Cruz

    2015-07-15

    Purpose: The aim was to investigate whole-body and red marrow absorbed doses in treatments of neuroblastoma (NB) and adult neuroendocrine tumors (NETs) with {sup 131}I-metaiodobenzylguanidine and to propose a simple method for determining the activity to administer when dosimetric data for the individual patient are not available. Methods: Nine NB patients and six NET patients were included, giving in total 19 treatments as four patients were treated twice. Whole-body absorbed doses were determined from dose-rate measurements and planar gamma-camera imaging. For six NB and five NET treatments, red marrow absorbed doses were also determined using the blood-based method. Results: Dosimetric data from repeated administrations in the same patient were consistent. In groups of NB and NET patients, similar whole-body residence times were obtained, implying that whole-body absorbed dose per unit of administered activity could be reasonably well described as a power function of the patient mass. For NB, this functional form was found to be consistent with dosimetric data from previously published studies. The whole-body to red marrow absorbed dose ratio was similar among patients, with values of 1.4 ± 0.6–1.7 ± 0.7 (1 standard deviation) in NB treatments and between 1.5 ± 0.6 and 1.7 ± 0.7 (1 standard deviation) in NET treatments. Conclusions: The consistency of dosimetric results between administrations for the same patient supports prescription of the activity based on dosimetry performed in pretreatment studies, or during the first administration in a fractionated schedule. The expressions obtained for whole-body absorbed doses per unit of administered activity as a function of patient mass for NB and NET treatments are believed to be a useful tool to estimate the activity to administer at the stage when the individual patient biokinetics has not yet been measured.

  4. The Superior Energy Performance program, administered by DOE, certifies industrial facilities that implement an ISO 50001 compliant energy management system and achieve improved energy performance.

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Superior Energy Performance® Certifying Increased Energy Productivity under ISO 50001 The Superior Energy Performance ® (SEP(tm)) program, administered by the U.S. Department of Energy (DOE), certifies industrial facilities that implement an ISO 50001 compliant energy management system standard and achieve improved energy performance 1 . In addition DOE's SEP program adds a verification component that ensures energy savings. SEP builds on ISO 50001 and creates a roadmap that can guide

  5. Rational Ligand Design for U(VI) and Pu(IV)

    SciTech Connect

    Szigethy, Geza

    2009-08-12

    Nuclear power is an attractive alternative to hydrocarbon-based energy production at a time when moving away from carbon-producing processes is widely accepted as a significant developmental need. Hence, the radioactive actinide power sources for this industry are necessarily becoming more widespread, which is accompanied by the increased risk of exposure to both biological and environmental systems. This, in turn, requires the development of technology designed to remove such radioactive threats efficiently and selectively from contaminated material, whether that be contained nuclear waste streams or the human body. Raymond and coworkers (University of California, Berkeley) have for decades investigated the interaction of biologically-inspired, hard Lewis-base ligands with high-valent, early-actinide cations. It has been established that such ligands bind strongly to the hard Lewis-acidic early actinides, and many poly-bidentate ligands have been developed and shown to be effective chelators of actinide contaminants in vivo. Work reported herein explores the effect of ligand geometry on the linear U(IV) dioxo dication (uranyl, UO{sub 2}{sup 2+}). The goal is to utilize rational ligand design to develop ligands that exhibit shape selectivity towards linear dioxo cations and provides thermodynamically favorable binding interactions. The uranyl complexes with a series of tetradentate 3-hydroxy-pyridin-2-one (3,2-HOPO) ligands were studied in both the crystalline state as well as in solution. Despite significant geometric differences, the uranyl affinities of these ligands vary only slightly but are better than DTPA, the only FDA-approved chelation therapy for actinide contamination. The terepthalamide (TAM) moiety was combined into tris-beidentate ligands with 1,2- and 3,2-HOPO moieties were combined into hexadentate ligands whose structural preferences and solution thermodynamics were measured with the uranyl cation. In addition to achieving coordinative saturation

  6. A rational approach for evaluation and screening of treatment and disposal options for the solar pond sludges at Rocky Flats

    SciTech Connect

    Dickerson, K.S.

    1995-12-31

    This document consists of information about the treatment options for the sludge that is located in the evaporation ponds at the Rocky Flats Plant. The sludges are mixed low-level radioactive wastes whose composition and character were variable. Sludges similar to these are typically treated prior to ultimate disposal. Disposal of treated sludges includes both on-site and off-site options. The rational approach described in this paper is useful for technology evaluation and screening because it provides a format for developing objectives, listing alternatives, and weighing the alternatives against the objectives and against each other.

  7. SANDIA COKPOK4TION SANDIA BASE, .QLDUQUERQUE. N. M.

    Office of Legacy Management (LM)

    F. k e r s , R. F. Beers, Inc. S. E . J e r m e , Univ. of Nev., Xeno %. L, B r m e , i h z e l t o n Nuclear Science Corp. 0. R. P l a c k , USPXS, Las Vegas, Nev. G. H. H i g ...

  8. The Promiscuity of [beta]-Strand Pairing Allows for Rational Design of [beta]-Sheet Face Inversion

    SciTech Connect

    Makabe, Koki; Koide, Shohei

    2009-06-17

    Recent studies suggest the dominant role of main-chain H-bond formation in specifying {beta}-sheet topology. Its essentially sequence-independent nature implies a large degree of freedom in designing {beta}-sheet-based nanomaterials. Here we show rational design of {beta}-sheet face inversions by incremental deletions of {beta}-strands from the single-layer {beta}-sheet of Borrelia outer surface protein A. We show that a {beta}-sheet structure can be maintained when a large number of native contacts are removed and that one can design large-scale conformational transitions of a {beta}-sheet such as face inversion by exploiting the promiscuity of strand-strand interactions. High-resolution X-ray crystal structures confirmed the success of the design and supported the importance of main-chain H-bonds in determining {beta}-sheet topology. This work suggests a simple but effective strategy for designing and controlling nanomaterials based on {beta}-rich peptide self-assemblies.

  9. Rationalizing the role of structural motif and underlying electronic structure in the finite temperature behavior of atomic clusters

    SciTech Connect

    Susan, Anju; Joshi, Kavita

    2014-04-21

    Melting in finite size systems is an interesting but complex phenomenon. Many factors affect melting and owing to their interdependencies it is a challenging task to rationalize their roles in the phase transition. In this work, we demonstrate how structural motif of the ground state influences melting transition in small clusters. Here, we report a case with clusters of aluminum and gallium having same number of atoms, valence electrons, and similar structural motif of the ground state but drastically different melting temperatures. We have employed Born-Oppenheimer molecular dynamics to simulate the solid-like to liquid-like transition in these clusters. Our simulations have reproduced the experimental trends fairly well. Further, the detailed analysis of isomers has brought out the role of the ground state structure and underlying electronic structure in the finite temperature behavior of these clusters. For both clusters, isomers accessible before cluster melts have striking similarities and does have strong influence of the structural motif of the ground state. Further, the shape of the heat capacity curve is similar in both the cases but the transition is more spread over for Al{sub 36} which is consistent with the observed isomerization pattern. Our simulations also suggest a way to characterize transition region on the basis of accessibility of the ground state at a specific temperature.

  10. Rational design of efficient electrode–electrolyte interfaces for solid-state energy storage using ion soft landing

    DOE PAGES [OSTI]

    Prabhakaran, Venkateshkumar; Mehdi, B. Layla; Ditto, Jeffrey J.; Engelhard, Mark H.; Wang, Bingbing; Gunaratne, K. Don D.; Johnson, David C.; Browning, Nigel D.; Johnson, Grant E.; Laskin, Julia

    2016-04-21

    Here, the rational design of improved electrode-electrolyte interfaces (EEI) for energy storage is critically dependent on a molecular-level understanding of ionic interactions and nanoscale phenomena. The presence of non-redox active species at EEI has been shown to strongly influence Faradaic efficiency and long-term operational stability during energy storage processes. Herein, we achieve substantially higher performance and long-term stability of EEI prepared with highly-dispersed discrete redox-active cluster anions (50 ng of pure ~0.7 nm size molybdenum polyoxometalate anions (POM) anions on 25 mg (≈ 0.2 wt%) carbon nanotube (CNT) electrodes) by complete elimination of strongly coordinating non-redox species through ion soft-landingmore » (SL). For the first time, electron microscopy provides atomically-resolved images of individual POM species directly on complex technologically relevant CNT electrodes. In this context, SL is established as a versatile approach for the controlled design of novel surfaces for both fundamental and applied research in energy storage.« less

  11. Rational engineering of Geobacter sulfurreducens electron transfer components: A foundation for building improved Geobacter-based bioelectrochemical technologies

    DOE PAGES [OSTI]

    Dantas, Joana M.; Morgado, Leonor; Aklujkar, Muktak; Bruix, Marta; Londer, Yuri Y.; Schiffer, Marianne; Pokkuluri, P. Raj; Salgueiro, Carlos A.

    2015-07-30

    Multiheme cytochromes have been implicated in Geobacter sulfurreducens extracellular electron transfer (EET). These proteins are potential targets to improve EET and enhance bioremediation and electrical current production by G. sulfurreducens. However, the functional characterization of multiheme cytochromes is particularly complex due to the co-existence of several microstates in solution, connecting the fully reduced and fully oxidized states. Throughout the last decade, new strategies have been developed to characterize multiheme redox proteins functionally and structurally. These strategies were used to reveal the functional mechanism of G. sulfurreducens multiheme cytochromes and also to identify key residues in these proteins for EET. Inmore » previous studies, we set the foundations for enhancement of the EET abilities of G. sulfurreducens by characterizing a family of five triheme cytochromes (PpcA-E). These periplasmic cytochromes are implicated in electron transfer between the oxidative reactions of metabolism in the cytoplasm and the reduction of extracellular terminal electron acceptors at the cell's outer surface. The results obtained suggested that PpcA can couple e-/H+ transfer, a property that might contribute to the proton electrochemical gradient across the cytoplasmic membrane for metabolic energy production. The structural and functional properties of PpcA were characterized in detail and used for rational design of a family of 23 single site PpcA mutants. In this review, we summarize the functional characterization of the native and mutant proteins. Mutants that retain the mechanistic features of PpcA and adopt preferential e-/H+ transfer pathways at lower reduction potential values compared to the wild-type protein were selected for in vivo studies as the best candidates to increase the electron transfer rate of G. sulfurreducens. For the first time G. sulfurreducens strains have been manipulated by the introduction of mutant forms of

  12. Mechanism of imidazolium ionic liquids toxicity in Saccharomyces cerevisiae and rational engineering of a tolerant, xylose-fermenting strain

    DOE PAGES [OSTI]

    Dickinson, Quinn; Bottoms, Scott; Hinchman, Li; McIlwain, Sean; Li, Sheena; Myers, Chad L.; Boone, Charles; Coon, Joshua J.; Hebert, Alexander; Sato, Trey K.; et al

    2016-01-20

    In this study, imidazolium ionic liquids (IILs) underpin promising technologies that generate fermentable sugars from lignocellulose for future biorefineries. However, residual IILs are toxic to fermentative microbes such as Saccharomyces cerevisiae, making IIL-tolerance a key property for strain engineering. To enable rational engineering, we used chemical genomic profiling to understand the effects of IILs on S. cerevisiae. As a result, we found that IILs likely target mitochondria as their chemical genomic profiles closely resembled that of the mitochondrial membrane disrupting agent valinomycin. Further, several deletions of genes encoding mitochondrial proteins exhibited increased sensitivity to IIL. High-throughput chemical proteomics confirmed effectsmore » of IILs on mitochondrial protein levels. IILs induced abnormal mitochondrial morphology, as well as altered polarization of mitochondrial membrane potential similar to valinomycin. Deletion of the putative serine/threonine kinase PTK2 thought to activate the plasma-membrane proton efflux pump Pma1p conferred a significant IIL-fitness advantage. Conversely, overexpression of PMA1 conferred sensitivity to IILs, suggesting that hydrogen ion efflux may be coupled to influx of the toxic imidazolium cation. PTK2 deletion conferred resistance to multiple IILs, including [EMIM]Cl, [BMIM]Cl, and [EMIM]Ac. An engineered, xylose-converting ptk2Δ S. cerevisiae (Y133-IIL) strain consumed glucose and xylose faster and produced more ethanol in the presence of 1 % [BMIM]Cl than the wild-type PTK2 strain. We propose a model of IIL toxicity and resistance. In conclusion, this work demonstrates the utility of chemical genomics-guided biodesign for development of superior microbial biocatalysts for the ever-changing landscape of fermentation inhibitors.« less

  13. Rational Reprogramming of the R2 Subunit of Escherichia coli Ribonucleotide Reductase into a Self-Hydroxylating Monooxygenase

    SciTech Connect

    Baldwin, J.; Voegtli, W.C.; Khidekel, N.; Moënne-Loccoz, P.; Krebs, C.; Ley, B.A.; Huynh, B.H.; Loehr, T.M.; Rosenzweig, A.C.; Bollinger, Jr., J.M.

    2010-03-05

    The outcome of O{sub 2} activation at the diiron(II) cluster in the R2 subunit of Escherichia coli (class I) ribonucleotide reductase has been rationally altered from the normal tyrosyl radical (Y122) production to self-hydroxylation of a phenylalanine side-chain by two amino acid substitutions that leave intact the (histidine){sub 2}-(carboxylate){sub 4} ligand set characteristic of the diiron-carboxylate family. Iron ligand Asp (D) 84 was replaced with Glu (E), the amino acid found in the cognate position of the structurally similar diiron-carboxylate protein, methane monooxygenase hydroxylase (MMOH). We previously showed that this substitution allows accumulation of a {mu}-1,2-peroxodiiron(III) intermediate, which does not accumulate in the wild-type (wt) protein and is probably a structural homologue of intermediate P (H{sub peroxo}) in O{sub 2} activation by MMOH. In addition, the near-surface residue Trp (W) 48 was replaced with Phe (F), blocking transfer of the 'extra' electron that occurs in wt R2 during formation of the formally Fe(III)Fe(IV) cluster X. Decay of the {mu}-1,2-peroxodiiron(III) complex in R2-W48F/D84E gives an initial brown product, which contains very little Y122 and which converts very slowly (t{sub 1/2} {approx} 7 h) upon incubation at 0 C to an intensely purple final product. X-ray crystallographic analysis of the purple product indicates that F208 has undergone {epsilon}-hydroxylation and the resulting phenol has shifted significantly to become a ligand to Fe2 of the diiron cluster. Resonance Raman (RR) spectra of the purple product generated with {sup 16}O{sub 2} or {sub 18}O{sub 2} show appropriate isotopic sensitivity in bands assigned to O-phenyl and Fe-O-phenyl vibrational modes, confirming that the oxygen of the Fe(III)-phenolate species is derived from O{sub 2}. Chemical analysis, experiments involving interception of the hydroxylating intermediate with exogenous reductant, and Moessbauer and EXAFS characterization of the brown

  14. Laws DOE Administers | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Click here to learn more about Adobe Reader. Laws Albert Einstein Distinguished Educator Fellowship Act of 1994 Albert Einstein Distinguished Educator Fellowship Act of 1994 in ...

  15. Administering Workforce Discipline (Informational Purposes Only)

    Directives, Delegations, and Other Requirements [Office of Management (MA)]

    2015-01-26

    This draft has been scheduled for final review before the Directives Review Board on 02/5/2015. All major comments and concerns should be provided to your DRB representative by 02/3/2015, following your organization process. If you do not know who your representative is, please see the list of DRB members. If your office is represented by Ingrid Kolb, Director, Office of Management, please submit your major concerns and comments to the DRB Liaison, Camille Beben (Camille.Beben@hq.doe.gov; 202-586-1014).

  16. Process for Administering Distributed Academic Competitions

    SciTech Connect

    Feibush, Eliot

    2010-02-04

    Currently, academic-type competitions are scored using a combination of timer clocks, entries on paper, and individual computers to consolidate individual entries. Such a system is unwieldy, time-consuming, and depends on the individual computer skills that might be present amount the competition administrators. The new Academic Competition Software combines digital clocks, along with a scoring system that permits different point values for different types of questions. Bonus or ??toss-up? questions can be monitored during the competition, using a subtimer system. All data is consolidated on the fly and the system can be operated by a single person. Results from different sites (rooms) can be added in as well. As such, the software is extremely flexible. It is anticipated that this new software will be useful for?Science or Science Olympiad type competitions held in many high schools and colleges, as well as for preparation and training for such competitions.

  17. Process for Administering Distributed Academic Competitions

    Energy Science and Technology Software Center

    2010-02-04

    Currently, academic-type competitions are scored using a combination of timer clocks, entries on paper, and individual computers to consolidate individual entries. Such a system is unwieldy, time-consuming, and depends on the individual computer skills that might be present amount the competition administrators. The new Academic Competition Software combines digital clocks, along with a scoring system that permits different point values for different types of questions. Bonus or ‚Âœtoss-up‚ questions can be monitored during the competition,more » using a subtimer system. All data is consolidated on the fly and the system can be operated by a single person. Results from different sites (rooms) can be added in as well. As such, the software is extremely flexible. It is anticipated that this new software will be useful for‚Science or Science Olympiad type competitions held in many high schools and colleges, as well as for preparation and training for such competitions.« less

  18. Administering Nonprofit Energy Efficiency Programs | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    PDF icon Call Slides and Discussion Summary More Documents & Publications Assessing Revenue Streams: What Is Right for Your Program? Program Support From Socially Responsible...

  19. Combined state-adding and state-deleting approaches to type III multi-step rationally extended potentials: Applications to ladder operators and superintegrability

    SciTech Connect

    Marquette, Ian; Quesne, Christiane

    2014-11-15

    Type III multi-step rationally extended harmonic oscillator and radial harmonic oscillator potentials, characterized by a set of k integers m{sub 1}, m{sub 2}, ⋯, m{sub k}, such that m{sub 1} < m{sub 2} < ⋯ < m{sub k} with m{sub i} even (resp. odd) for i odd (resp. even), are considered. The state-adding and state-deleting approaches to these potentials in a supersymmetric quantum mechanical framework are combined to construct new ladder operators. The eigenstates of the Hamiltonians are shown to separate into m{sub k} + 1 infinite-dimensional unitary irreducible representations of the corresponding polynomial Heisenberg algebras. These ladder operators are then used to build a higher-order integral of motion for seven new infinite families of superintegrable two-dimensional systems separable in cartesian coordinates. The finite-dimensional unitary irreducible representations of the polynomial algebras of such systems are directly determined from the ladder operator action on the constituent one-dimensional Hamiltonian eigenstates and provide an algebraic derivation of the superintegrable systems whole spectrum including the level total degeneracies.

  20. Nature-oriented open coal mining technologies using mined-out space in an open-pit. Part II: A method for selecting rational sequence of mining flat dipping stratified deposits

    SciTech Connect

    Molotilov, S.G.; Norri, V.K.; Cheskidov, V.I.; Mattis, A.R.

    2007-01-15

    A method is proposed for selecting a rational mining sequence with internal dumping for flat stratified deposits, using new principles of the open-pit process-space formation and development. The main criteria for substantiating the mining sequence are geometrical form and development direction of the open-pit space, structure of the working wall and transportation network, internal dumping capacities and mining earthworks volumes.

  1. ADVANTG 3.0.1: AutomateD VAriaNce reducTion Generator

    Energy Science and Technology Software Center

    2015-08-17

    Version 00 ADVANTG is an automated tool for generating variance reduction parameters for fixed-source continuous-energy Monte Carlo simulations with MCNP5 V1.60 (CCC-810, not included in this distribution) based on approximate 3-D multigroup discrete ordinates adjoint transport solutions generated by Denovo (included in this distribution). The variance reduction parameters generated by ADVANTG consist of space and energy-dependent weight-window bounds and biased source distributions, which are output in formats that can be directly used with unmodified versionsmore » of MCNP5. ADVANTG has been applied to neutron, photon, and coupled neutron-photon simulations of real-world radiation detection and shielding scenarios. ADVANTG is compatible with all MCNP5 geometry features and can be used to accelerate cell tallies (F4, F6, F8), surface tallies (F1 and F2), point-detector tallies (F5), and Cartesian mesh tallies (FMESH).« less

  2. Rational engineering of Geobacter sulfurreducens electron transfer components: A foundation for building improved Geobacter-based bioelectrochemical technologies

    SciTech Connect

    Dantas, Joana M.; Morgado, Leonor; Aklujkar, Muktak; Bruix, Marta; Londer, Yuri Y.; Schiffer, Marianne; Pokkuluri, P. Raj; Salgueiro, Carlos A.

    2015-07-30

    Multiheme cytochromes have been implicated in Geobacter sulfurreducens extracellular electron transfer (EET). These proteins are potential targets to improve EET and enhance bioremediation and electrical current production by G. sulfurreducens. However, the functional characterization of multiheme cytochromes is particularly complex due to the co-existence of several microstates in solution, connecting the fully reduced and fully oxidized states. Throughout the last decade, new strategies have been developed to characterize multiheme redox proteins functionally and structurally. These strategies were used to reveal the functional mechanism of G. sulfurreducens multiheme cytochromes and also to identify key residues in these proteins for EET. In previous studies, we set the foundations for enhancement of the EET abilities of G. sulfurreducens by characterizing a family of five triheme cytochromes (PpcA-E). These periplasmic cytochromes are implicated in electron transfer between the oxidative reactions of metabolism in the cytoplasm and the reduction of extracellular terminal electron acceptors at the cell's outer surface. The results obtained suggested that PpcA can couple e-/H+ transfer, a property that might contribute to the proton electrochemical gradient across the cytoplasmic membrane for metabolic energy production. The structural and functional properties of PpcA were characterized in detail and used for rational design of a family of 23 single site PpcA mutants. In this review, we summarize the functional characterization of the native and mutant proteins. Mutants that retain the mechanistic features of PpcA and adopt preferential e-/H+ transfer pathways at lower reduction potential values compared to the wild-type protein were selected for in vivo studies as the best candidates to increase the electron transfer rate of G. sulfurreducens. For the first time G. sulfurreducens

  3. Significance determination: A rational reconstruction of decisions

    SciTech Connect

    Kjellerup, U.

    1999-01-01

    This article deals with some screening environmental impact assessments (EIAs) that have been reviewed and decided by an administrative board, the Appeal Board for Nature Protection. The practices developed by the Appeal Board show that the handling of significance in screening lacks focus, which leads to a mix of problems; namely, inconsistent argumentation and the development of practices not compliant with the usual understanding of EIA. The problems are found in project-related screening cases as well as in general screening cases. The article argues that structural barriers in Danish EIA regulations hinder the function of the EIA system in general. The article also touches upon the problems of implementing EIA into existing legal frameworks and present the view that a Board composed mainly of politicians cannot be the right body to enforce the procedural rules of the EIA-system.

  4. Title 40 CFR 122 EPA Administered Permit Programs: NPDES | Open...

    OpenEI (Open Energy Information) [EERE & EIA]

    Permit Programs: NPDESLegal Published NA Year Signed or Took Effect 2013 Legal Citation 40 CFR 122 DOI Not Provided Check for DOI availability: http:crossref.org Online...

  5. Title 40 Protection of Environment Part 122 EPA Administered...

    OpenEI (Open Energy Information) [EERE & EIA]

    Permit for National Pollution Discharge Elimination System requirements, under the Clean Water Act. Published NA Year Signed or Took Effect 1983 Legal Citation 40 CFR...

  6. Grant Guidance to Administer the American Recovery and Reinvestment...

    Energy.gov [DOE] (indexed site)

    the Recovery Act because it raised the income eligibility for the Program from 150% of poverty to 200% of poverty. The Department of Energy has modified the inputs to the...

  7. SF 4300-CRC;COMPLETION RECORD FOR CONTRACTOR ADMINISTERED TRAINING

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    for your records Provide the original to your employee If the agreement is a: Human Resource Staff Augmentation contract (the Staffing Requisition originated in Human Resources),...

  8. Hydrolysis of DFP and the Nerve Agent (S)-Sarin by DFPase Proceeds Along Two Different Reaction Pathways: Implica-tions for Engineering Bioscavengers

    SciTech Connect

    Wymore, Troy W; Langan, Paul; Smith, Jeremy C; Field, Martin J.; Parks, Jerry M

    2014-01-01

    Organophosphorus (OP) nerve agents such as (S)-sarin are among the most highly toxic compounds that have been synthesized. Engineering enzymes that catalyze the hydrolysis of nerve agents ( bioscavengers ) is an emerging prophylactic approach to diminishing their toxic effects. Although its native function is not known, diisopropyl fluorophosphatase (DFPase) from Loligo vulgaris catalyzes the hydrolysis of OP compounds. Here, we investigate the mechanisms of diisopropylfluorophosphate (DFP) and (S)-sarin hydrolysis by DFPase with quantum mechanical/molecular mechanical (QM/MM) umbrella sampling simulations. We find that the mechanism for hydrolysis of DFP involves nucleophilic attack by Asp229 on phosphorus to form a pentavalent intermediate. P F bond dissociation then yields a phosphoacyl enzyme intermediate in the rate-limiting step. The simulations suggest that a water molecule, coordinated to the catalytic Ca2+, donates a proton to Asp121 and then attacks the tetrahedral phosphoacyl intermediate to liberate the diisopropylphosphate product. In contrast, the calculated free energy barrier for hydrolysis of (S)-sarin by the same mechanism is highly unfavorable, primarily due to the instability of the pentavalent phosphoenzyme species. Instead, simulations suggest that hydrolysis of (S)-sarin proceeds by a mechanism in which Asp229 could activate an intervening water molecule for nucleophilic attack on the substrate. These findings may lead to improved strategies for engineering DFPase and related six-bladed -propeller folds for more efficient degradation of OP compounds.

  9. Rational Design and Adaptive Management of Combination Therapies...

    Office of Scientific and Technical Information (OSTI)

    of Combination Therapies for Hepatitis C Virus Infection CrossMark click for updates n ... Design and Adaptive Management of Combination Therapies for Hepatitis C Virus Infection. ...

  10. Rational design of a split-Cas9 enzyme complex

    SciTech Connect

    Wright, Addison V.; Sternberg, Samuel H.; Taylor, David W.; Staahl, Brett T.; Bardales, Jorge A.; Kornfeld, Jack E.; Doudna, Jennifer A.

    2015-02-23

    Cas9, an RNA-guided DNA endonuclease found in clustered regularly interspaced short palindromic repeats (CRISPR) bacterial immune systems, is a versatile tool for genome editing, transcriptional regulation, and cellular imaging applications. Structures of Streptococcus pyogenes Cas9 alone or bound to single-guide RNA (sgRNA) and target DNA revealed a bilobed protein architecture that undergoes major conformational changes upon guide RNA and DNA binding. To investigate the molecular determinants and relevance of the interlobe rearrangement for target recognition and cleavage, we designed a split-Cas9 enzyme in which the nuclease lobe and ?-helical lobe are expressed as separate polypeptides. The lobes do not interact on their own, the sgRNA recruits them into a ternary complex that recapitulates the activity of full-length Cas9 and catalyzes site-specific DNA cleavage. The use of a modified sgRNA abrogates split-Cas9 activity by preventing dimerization, allowing for the development of an inducible dimerization system. We propose that split-Cas9 can act as a highly regulatable platform for genome-engineering applications.

  11. Understanding Thin Film Structure for the Rational Design of...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    transistors (OTFT) can be achieved through molecular design by selective placement of electron-rich, electron-withdrawing, and aromatic groups in different parts of the molecule. ...

  12. Alveolar targeting of aerosol pentamidine. Toward a rational delivery system

    SciTech Connect

    Simonds, A.K.; Newman, S.P.; Johnson, M.A.; Talaee, N.; Lee, C.A.; Clarke, S.W. )

    1990-04-01

    Nebulizer systems that deposit a high proportion of aerosolized pentamidine on large airways are likely to be associated with marked adverse side effects, which may lead to premature cessation of treatment. We have measured alveolar deposition and large airway-related side effects (e.g., cough, breathlessness, and effect on pulmonary function) after aerosolization of 150 mg pentamidine isethionate labeled with {sup 99m}Tc-Sn-colloid. Nine patients with AIDS were studied using three nebulizer systems producing different droplet size profiles: the Acorn System 22, Respirgard II, and Respirgard II with the inspiratory baffle removed. Alveolar deposition was greatest and side effects least with the nebulizer producing the smallest droplet size profile (Respirgard II), whereas large airway-related side effects were prominent and alveolar deposition lowest with the nebulizer producing the largest droplet size (Acorn System 22). Values for alveolar deposition and adverse airway effects were intermediate using the Respirgard with inspiratory baffle removed, thus indicating the importance of the baffle valve in determining droplet size. Addition of a similar baffle valve to the Acorn System 22 produced a marked improvement in droplet size profile. Selection of a nebulizer that produces an optimal droplet size range offers the advantage of enhancing alveolar targeting of aerosolized pentamidine while reducing large airway-related side effects.

  13. Rational design of a split-Cas9 enzyme complex

    DOE PAGES [OSTI]

    Wright, Addison V.; Sternberg, Samuel H.; Taylor, David W.; Staahl, Brett T.; Bardales, Jorge A.; Kornfeld, Jack E.; Doudna, Jennifer A.

    2015-02-23

    Cas9, an RNA-guided DNA endonuclease found in clustered regularly interspaced short palindromic repeats (CRISPR) bacterial immune systems, is a versatile tool for genome editing, transcriptional regulation, and cellular imaging applications. Structures of Streptococcus pyogenes Cas9 alone or bound to single-guide RNA (sgRNA) and target DNA revealed a bilobed protein architecture that undergoes major conformational changes upon guide RNA and DNA binding. To investigate the molecular determinants and relevance of the interlobe rearrangement for target recognition and cleavage, we designed a split-Cas9 enzyme in which the nuclease lobe and α-helical lobe are expressed as separate polypeptides. The lobes do not interactmore » on their own, the sgRNA recruits them into a ternary complex that recapitulates the activity of full-length Cas9 and catalyzes site-specific DNA cleavage. The use of a modified sgRNA abrogates split-Cas9 activity by preventing dimerization, allowing for the development of an inducible dimerization system. We propose that split-Cas9 can act as a highly regulatable platform for genome-engineering applications.« less

  14. High-Performance Polymer Photovoltaics with Rationally Designed...

    Office of Scientific and Technical Information (OSTI)

    DOE Contract Number: DE-AC05-00OR22725 Resource Type: Journal Article Resource Relation: Journal Name: Solar Energy Materials and Solar Cells; Journal Volume: 118 Research Org: Oak ...

  15. Rationalization of Au concentration and distribution in AuNi...

    Office of Scientific and Technical Information (OSTI)

    Here, using density functional theory, we report the effect of adding Au as the third ... Country of Publication: United States Language: English Subject: 37 INORGANIC, ORGANIC, ...

  16. Verification of the ideal magnetohydrodynamic response at rational...

    Office of Scientific and Technical Information (OSTI)

    New Jersey 08543, USA Max-Planck-Institut fr Plasmaphysik, Greifswald 17491, Germany Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA Publication Date:...

  17. Computing Eigenvalues of Real Symmetric Matrices Using Rational...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    matrices are real symmetric, most such methods rely on complex arithmetic, to solve the linear systems that arise in their implementations. An appealing technique for overcoming...

  18. EMCBC Honored for Helping Administer American Recovery and Reinvestment Act Funds

    Energy.gov [DOE]

    DOE’s Office of Energy Efficiency and Renewable Energy (EERE) honored the Cincinnati-based EM Consolidated Business Center (EMCBC) this month for work EMCBC completed under the American Reinvestment and Recovery Act.

  19. LANL/LANS 2015 BCBSNM-Administered Medical Programs: ACTIVE EMPLOYEES...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    waived) 40% after deductible 10% after deductible 40% after deductible Behavioral Health: Mental HealthChemical Dependency Office 30visit (deductible waived) 40% after...

  20. Statistical Analysis of the Worker Engagement Survey Administered at the Worker Safety and Security Team Festival

    SciTech Connect

    Davis, Adam Christopher

    2015-08-25

    The Worker Safety and Security Team (WSST) at Los Alamos National Laboratory holds an annual festival, WSST-fest, to engage workers and inform them about safety- and securityrelated matters. As part of the 2015 WSST-fest, workers were given the opportunity to participate in a survey assessing their engagement in their organizations and work environments. A total of 789 workers participated in the 23-question survey where they were also invited, optionally, to identify themselves, their organization, and to give open-ended feedback. The survey consisted of 23 positive statements (i.e. “My organization is a good place to work.”) with which the respondent could express a level of agreement. The text of these statements are provided in Table 1. The level of agreement corresponds to a 5-level Likert scale ranging from “Strongly Disagree” to “Strongly Agree.” In addition to assessing the overall positivity or negativity of the scores, the results were partitioned into several cohorts based on the response meta-data (self-identification, comments, etc.) to explore trends. Survey respondents were presented with the options to identify themselves, their organizations and to provide comments. These options suggested the following questions about the data set.

  1. Grant Guidance to Administer the American Recovery and Reinvestment Act of 2009 Funding

    Office of Energy Efficiency and Renewable Energy (EERE)

    U.S. Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) Weatherization Assistance Program Notice 09-01B deals with guidance to program grantees„states and U.S. territories„for spending funding from the 2009 Recovery Act for weatherization.

  2. Final Report for grant 50105251, entitled AN OPEN SOURCE PLATFORM FOR MULTI-SCALE SPATIALLY DISTRIBUTED SIMULA TIONS OF MICROBIAL ECOSYSTEMS, DOE # DE-SC0004962, period 8/15/2010 – 8/14/2014

    SciTech Connect

    Segre, Daniel

    2015-12-09

    The goal of this project was to develop a tool for facilitating simulation, validation and discovery of multiscale dynamical processes in microbial ecosystems. This led to the development of an open-source software platform for Computation Of Microbial Ecosystems in Time and Space (COMETS). COMETS performs spatially distributed time-dependent flux balance based simulations of microbial metabolism. Our plan involved building the software platform itself, calibrating and testing it through comparison with experimental data, and integrating simulations and experiments to address important open questions on the evolution and dynamics of cross-feeding interactions between microbial species.

  3. Metabolomic changes in follicular fluid induced by soy isoflavones administered to rats from weaning until sexual maturity

    SciTech Connect

    Wang, Wenxiang; Zhang, Wenchang; Liu, Jin; Sun, Yan; Li, Yuchen; Li, Hong; Xiao, Shihua; Shen, Xiaohua

    2013-06-15

    Female Wistar rats at 21 days of age were treated with one of three concentrations of soy isoflavones (SIF) (50, 100 or 200 mg/kg body weight, orally, once per day) from weaning until sexual maturity (3 months) in order to evaluate the influence of SIF on ovarian follicle development. After treatment, the serum sex hormone levels and enumeration of ovarian follicles of the ovary were measured. The metabolic profile of follicular fluid was determined using HPLC-MS. Principal component analysis (PCA) and partial least-squares-discriminant analysis (PLS-DA) was used to identify differences in metabolites and reveal useful toxic biomarkers. The results indicated that modest doses of SIF affect ovarian follicle development, as demonstrated by decreased serum estradiol levels and increases in both ovarian follicle atresia and corpora lutea number in the ovary. SIF treatment-related metabolic alterations in follicular fluid were also found in the PCA and PLS-DA models. The 24 most significantly altered metabolites were identified, including primary sex hormones, amino acids, fatty acids and metabolites involved in energy metabolism. These findings may indicate that soy isoflavones affect ovarian follicle development by inducing metabolomic variations in the follicular fluid. - Highlights: ► Modest doses of soy isoflavones (SIF) do affect ovarian follicle development. ► SIF treatment-related metabolic alterations in follicular fluid were found. ► The 24 most significantly altered metabolites were identified.

  4. Rational Design of Cesium-Selective Ionophores and Chemosensors: Dihydrocalix[4]arene Crown-6 Ethers

    SciTech Connect

    Sachleben, Richard A.; Bryan, Jeffrey C.; Brown, Gilbert M.; Engle, Nancy L.; Haverlock, Tamara J.; Hay, Benjamin P.; Urvoas, Agathe; Moyer, Bruce A.

    2003-12-15

    Molecular mechanics calculations performed on calix[4]arene crown-6 ethers predict that the 1,3-dihydro derivatives will exhibit greater complementarity for potassium and cesium ions than the parent 1,3-dialkoxy calix crowns. The X-ray crystal structures of 1,3-alt bis-octyloxycalix[4]arene benzocrown-6 ether, dihydrocalix[4]arene benzocrown-6 ether, and the cesium nitrate complex of dihydrocalix[4]arene benzocrown-6 ether were determined. The cesium complex structure corresponds closely to the structure predicted by molecular mechanics. The dihydrocalix[4]arene crown-6 ethers exhibit enhanced cesium selectivity in the extraction of alkali metal salts and provide a platform for a highly sensitive and selective cesium chemosensor.

  5. A rationalization of the Type IV loading dependence in theKrger...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    The clustering can be caused due to hydrogen bonding effects as is the case for methanol diffusion in NaY, or due to the temperatures being lower than the critical...

  6. Rational Design of High-Performance Li2S Cathodes - Joint Center for Energy

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    INCIDENCE OF AN OIL GLUT: WHO BENEFITS FROM CHEAP CRUDE OIL IN THE MIDWEST? Severin Borenstein Haas School of Business and Energy Institute at Haas U.C. Berkeley Ryan Kellogg Department of Economics University of Michigan The Midwest oil glut has changed old views about integration of world oil markets * Common statement, pre-2011: "It's a world oil market" * Increased oil production in Canadian tar sands and North Dakota Bakken field changed the Midwest from crude importing to

  7. Rational Catalyst Design Applied to Development of Advanced Oxidation Catalysts for Diesel Emission Control

    Energy.gov [DOE]

    Presentation given at the 2007 Diesel Engine-Efficiency & Emissions Research Conference (DEER 2007). 13-16 August, 2007, Detroit, Michigan. Sponsored by the U.S. Department of Energy's (DOE) Office of FreedomCAR and Vehicle Technologies (OFCVT).

  8. U-154: IBM Rational ClearQuest ActiveX Control Buffer Overflow...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    V-020: Apple QuickTime Multiple Flaws Let Remote Users Execute Arbitrary Code U-126: Cisco Adaptive Security Appliances Port Forwarder ActiveX Control Buffer Overflow ...

  9. Assessing data quality for a federal environmental restoration project: Rationalizing the requirements of multiple clients

    SciTech Connect

    Kiszka, V.R.; Carlsen, T.M.

    1994-07-01

    Most environmental restoration projects at federal facilities face the difficult task of melding the quality assurance (QA) requirements of multiple clients, as well as dealing with historical data that are often of unknown quality. At Lawrence Livermore National Laboratory (LLNL), we have successfully integrated the requirements of our multiple clients by carefully developing a QA program that efficiently meets our clients` needs. The Site 300 Experimental Test Site is operated by LLNL in support of its national defense program. The responsibility for conducting environmental contaminant investigations and restoration at Site 300 is vested in the Site 300 Environmental Restoration Project (Site 300 ERP) of LLNL`s Environmental Restoration Division. LLNL Site 300 ERP must comply with the QA requirements of several clients, which include: the LLNL Environmental Protection Department, the DOE, the US Environmental Protection Agency-Region IX (EPA), the California Regional Water Quality Control Board -- Central Valley Region, and the California Department of Toxic Substances Control. This comprehensive QA program was used to determine the acceptability of historical data. The Site 300 ERP began soil and ground water investigations in 1982. However, we did not begin receiving analytical quality assurance/quality control (QA/QC) data until 1989; therefore, the pre-1989 data that were collected are of unknown quality. The US EPA QAMS-005/80 defines data quality as the totality of features and characteristics of data that bears on its ability to satisfy a given purpose. In the current context, the characteristics of major importance are accuracy, precision, completeness, representativeness, and comparability. Using our established QA program, we determined the quality of this historical data based on its comparability to the post-1989 data. By accepting this historical data, we were able to save a considerable amount of money in recharacterization costs.

  10. Osilodrostat (LCI699), a potent 11β-hydroxylase inhibitor, administered in combination with the multireceptor-targeted somatostatin analog pasireotide: A 13-week study in rats

    SciTech Connect

    Li, Li; Vashisht, Kapil; Boisclair, Julie; Li, Wenkui; Lin, Tsu-han; Schmid, Herbert A.; Kluwe, William; Schoenfeld, Heidi; Hoffmann, Peter

    2015-08-01

    The somatostatin analog pasireotide and the 11β-hydroxylase inhibitor osilodrostat (LCI699) reduce cortisol levels by distinct mechanisms of action. There exists a scientific rationale to investigate the clinical efficacy of these two agents in combination. This manuscript reports the results of a toxicology study in rats, evaluating different doses of osilodrostat and pasireotide alone and in combination. Sixty male and 60 female rats were randomized into single-sex groups to receive daily doses of pasireotide (0.3 mg/kg/day, subcutaneously), osilodrostat (20 mg/kg/day, orally), osilodrostat/pasireotide in combination (low dose, 1.5/0.03 mg/kg/day; mid-dose, 5/0.1 mg/kg/day; or high dose, 20/0.3 mg/kg/day), or vehicle for 13 weeks. Mean body-weight gains from baseline to Week 13 were significantly lower in the pasireotide-alone and combined-treatment groups compared to controls, and were significantly higher in female rats receiving osilodrostat monotherapy. Osilodrostat and pasireotide monotherapies were associated with significant changes in the histology and mean weights of the pituitary and adrenal glands, liver, and ovary/oviduct. Osilodrostat alone was associated with adrenocortical hypertrophy and hepatocellular hypertrophy. In combination, osilodrostat/pasireotide did not exacerbate any target organ changes and ameliorated the liver and adrenal gland changes observed with monotherapy. C{sub max} and AUC{sub 0–24h} of osilodrostat and pasireotide increased in an approximately dose-proportional manner. In conclusion, the pasireotide and osilodrostat combination did not exacerbate changes in target organ weight or toxicity compared with either monotherapy, and had an acceptable safety profile; addition of pasireotide to the osilodrostat regimen may attenuate potential adrenal gland hyperactivation and hepatocellular hypertrophy, which are potential side effects of osilodrostat monotherapy. - Highlights: • We examined the target organ toxicity of SOM230 (pasireotide) and LCI699 (osilodrostat) alone or in combination. • Co-treatment with pasireotide and osilodrostat did not exacerbate target organ toxicity by either compound. • Co-treatment with pasireotide and osilodrostat did not change the systemic exposure of either compound. • Combination of pasireotide and osilodrostat appeared to ameliorate some of the target organ effects by either compound.

  11. Administered activity and metastatic cure probability during radioimmunotherapy of ovarian cancer in nude mice with {sup 211}At-MX35 F(ab'){sub 2}

    SciTech Connect

    Elgqvist, Joergen . E-mail: jorgen.elgqvist@radfys.gu.se; Andersson, Hakan; Bernhardt, Peter; Baeck, Tom; Claesson, Ingela; Hultborn, Ragnar; Jensen, Holger; Johansson, Bengt R.; Lindegren, Sture; Olsson, Marita; Palm, Stig; Warnhammar, Elisabet; Jacobsson, Lars

    2006-11-15

    Purpose: To elucidate the therapeutic efficacy of {alpha}-radioimmunotherapy of ovarian cancer in mice. This study: (i) estimated the minimum required activity (MRA), giving a reasonable high therapeutic efficacy; and (ii) calculated the specific energy to tumor cell nuclei and the metastatic cure probability (MCP) using various assumptions regarding monoclonal-antibody (mAb) distribution in measured tumors. The study was performed using the {alpha}-particle emitter Astatine-211 ({sup 211}At) labeled to the mAb MX35 F(ab'){sub 2}. Methods and Materials: Animals were inoculated intraperitoneally with {approx}1 x 10{sup 7} cells of the cell line NIH:OVCAR-3. Four weeks later animals were treated with 25, 50, 100, or 200 kBq {sup 211}At-MX35 F(ab'){sub 2} (n = 74). Another group of animals was treated with a nonspecific mAb: 100 kBq {sup 211}At-Rituximab F(ab'){sub 2} (n = 18). Eight weeks after treatment the animals were sacrificed and presence of macro- and microscopic tumors and ascites was determined. An MCP model was developed and compared with the experimentally determined tumor-free fraction (TFF). Results: When treatment was given 4 weeks after cell inoculation, the TFFs were 25%, 22%, 50%, and 61% after treatment with 25, 50, 100, or 200 kBq {sup 211}At-MX35 F(ab'){sub 2}, respectively, the specific energy to irradiated cell nuclei varying between {approx}2 and {approx}400 Gy. Conclusion: As a significant increase in the therapeutic efficacy was observed between the activity levels of 50 and 100 kBq (TFF increase from 22% to 50%), the conclusion was that the MRA is {approx}100 kBq {sup 211}At-MX35 F(ab'){sub 2}. MCP was most consistent with the TFF when assuming a diffusion depth of 30 {mu}m of the mAbs in the tumors.

  12. Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action

    SciTech Connect

    Kostov, Rumen V.; Knatko, Elena V.; McLaughlin, Lesley A.; Henderson, Colin J.; Zheng, Suqing; Huang, Jeffrey T.-J.; Honda, Tadashi; Dinkova-Kostova, Albena T.

    2015-09-25

    The acetylenic tricyclic bis(cyanoenone) TBE-31 is a highly potent cysteine targeting compound with a reversible covalent mode of action; its best-characterized target being Kelch-like ECH-associated protein-1 (Keap1), the cellular sensor for oxidants and electrophiles. TBE-31 reacts with cysteines of Keap1, impairing its ability to target nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) for degradation. Consequently, Nrf2 accumulates and orchestrates cytoprotective gene expression. In this study we investigated the pharmacokinetic and pharmacodynamic properties of TBE-31 in C57BL/6 mice. After a single oral dose of 10 μmol/kg (∼200 nmol/animal), the concentration of TBE-31 in blood exhibited two peaks, at 22.3 nM and at 15.5 nM, 40 min and 4 h after dosing, respectively, as determined by a quantitative stable isotope dilution LC-MS/MS method. The AUC{sub 0–24h} was 195.5 h/nmol/l, the terminal elimination half-life was 10.2 h, and the k{sub el} was 0.068 h{sup −1}. To assess the pharmacodynamics of Nrf2 activation by TBE-31, we determined the enzyme activity of its prototypic target, NAD(P)H:quinone oxidoreductase 1 (NQO1) and found it elevated by 2.4- and 1.5-fold in liver and heart, respectively. Continuous feeding for 18 days with diet delivering the same daily doses of TBE-31 under conditions of concurrent treatment with the immunosuppressive agent azathioprine had a similar effect on Nrf2 activation without any indications of toxicity. Together with previous reports showing the cytoprotective effects of TBE-31 in animal models of carcinogenesis, our results demonstrate the high potency, efficacy and suitability for chronic administration of cysteine targeting reversible covalent drugs. - Highlights: • TBE-31 is a cysteine targeting compound with a reversible covalent mode of action. • After a single oral dose, the blood concentration of TBE-31 exhibits two peaks. • Oral TBE-31 is a potent activator of Nrf2-dependent enzymes in multiple organs. • Chronic dietary administration of TBE-31 at doses that show efficacy is not toxic.

  13. Neoadjuvant Sandwich Treatment With Oxaliplatin and Capecitabine Administered Prior to, Concurrently With, and Following Radiation Therapy in Locally Advanced Rectal Cancer: A Prospective Phase 2 Trial

    SciTech Connect

    Gao, Yuan-Hong; Lin, Jun-Zhong; An, Xin; Luo, Jie-Lin; Cai, Mu-Yan; Cai, Pei-Qiang; Kong, Ling-Heng; Liu, Guo-Chen; Tang, Jing-Hua; Chen, Gong; Pan, Zhi-Zhong; Ding, Pei-Rong

    2014-12-01

    Purpose: Systemic failure remains the major challenge in management of locally advanced rectal cancer (LARC). To optimize the timing of neoadjuvant treatment and enhance systemic control, we initiated a phase 2 trial to evaluate a new strategy of neoadjuvant sandwich treatment, integrating induction chemotherapy, concurrent chemoradiation therapy, and consolidation chemotherapy. Here, we present preliminary results of this trial, reporting the tumor response, toxicities, and surgical complications. Methods and Materials: Fifty-one patients with LARC were enrolled, among which were two patients who were ineligible because of distant metastases before treatment. Patients were treated first with one cycle of induction chemotherapy consisting of oxaliplatin, 130 mg/m² on day 1, with capecitabine, 1000 mg/m² twice daily for 14 days every 3 weeks (the XELOX regimen), followed by chemoradiation therapy, 50 Gy over 5 weeks, with the modified XELOX regimen (oxaliplatin 100 mg/m²), and then with another cycle of consolidation chemotherapy with the XELOX regimen. Surgery was performed 6 to 8 weeks after completion of radiation therapy. Tumor responses, toxicities, and surgical complications were recorded. Results: All but one patent completed the planned schedule of neoadjuvant sandwich treatment. Neither life-threatening blood count decrease nor febrile neutropenia were observed. Forty-five patents underwent optimal surgery with total mesorectal excision (TME). Four patients refused surgery because of clinically complete response. There was no perioperative mortality in this cohort. Five patients (11.1%) developed postoperative complications. Among the 45 patients who underwent TME, pathologic complete response (pCR), pCR or major regression, and at least moderate regression were achieved in 19 (42.2%), 37 (82.2%), and 44 patients (97.8%), respectively. Conclusions: Preliminary results suggest that the strategy of neoadjuvant sandwich treatment using XELOX regimen as induction, concomitant, and consolidation chemotherapy to the conventional radiation is well tolerated. The strategy is highly effective in terms of pCR and major regression, which warrants further investigation.

  14. Structural Criteria for the Rational Design of Selective Ligands: Convergent Hydrogen Bonding Sites for the Nitrate Anion

    SciTech Connect

    Hay, Benjamin P.; Gutowski, Maciej S.; Dixon, David A.; Garza , Jorge; Vargas, Rubicelia; Moyer, Bruce A.

    2004-06-30

    Molecular hosts for anion complexation are often constructed by combining two or more hydrogen bonding functional groups, DH. The deliberate design of complementary host architectures requires knowledge of the optimal geometry for the hydrogen bonds formed between the host and the guest. Herein, we present a detailed study of the structural aspects of hydrogen bonding interactions with the NO3 anion. A large number of crystal structures are analyzed to determine the number of hydrogen bond contacts per anion and to further characterize the structural aspects of these interactions. Electronic structure calculations are used to determine stable geometries and interaction energies for NO3 complexes with several simple molecules possessing DH groups, including water, methanol, N-methylformamide, and methane. Theoretical results are reported at several levels of density functional theory, including BP86/DN**, B3LYP/TZVP, and B3LYP/TZVP+, and at MP2/aug-cc-pVDZ. In addition, MP2 binding energies for these complexes were obtained at the complete basis set limit by extrapolating from single point energies obtained with larger correlation-consistent basis sets. The results establish that NO3 has an intrinsic hydrogen bonding topography in which there are six optimal sites for proton location. The structural features observed in crystal structures and in the optimized geometries of complexes are explained by a preference to locate the DH protons in these positions. For the strongest hydrogen bonding interactions, the NOH angle is bent at an angle of 115 10, and the hydrogen atom lies in the NO3 plane giving ONOH dihedral angles of 0 and 180. In addition, the D-H vector points towards the oxygen atom, giving DHO angles that are near linear, 170 10. Due to steric hindrance, simple alcohol OH and amide NH donors form 3:1 complexes with NO3, with HO distances of 1.85 0.5 . Thus, the optimal cavity radius for a tridentate host, defined as the distance from the center to the DH hydrogen atoms, is 2.65 0.15 .

  15. Rational Design of Bi Nanoparticles for Efficient Electrochemical CO2 Reduction: The Elucidation of Size and Surface Condition Effects

    DOE PAGES [OSTI]

    Zhang, Zhiyong; Chi, Miaofang; Veith, Gabriel M.; Zhang, Pengfei; Lutterman, Daniel A.; Rosenthal, Joel; Overbury, Steven H.; Dai, Sheng; Zhu, Huiyuan

    2016-08-08

    Here we report an efficient electrochemical conversion of CO2 to CO on surface-activated bismuth nanoparticles (NPs) in acetonitrile (MeCN) under ambient conditions, with the assistance of 1-butyl-3-methylimidazolium trifluoromethanesulfonate ([bmim][OTf]). Through the comparison between electrodeposited Bi films (Bi-ED) and different types of Bi NPs, we, for the first time, demonstrate the effects of catalyst’s size and surface condition on organic phase electrochemical CO2 reduction. Our study reveals that the surface inhibiting layer (hydrophobic surfactants and Bi3+ species) formed during the synthesis and purification process hinders the CO2 reduction, leading to a 20% drop in Faradaic efficiency for CO evolution (FECO). Bimore » particle size showed a significant effect on FECO when the surface of Bi was air-oxidized, but this effect of size on FECO became negligible on surface-activated Bi NPs. After the surface activation (hydrazine treatment) that effectively removed the native inhibiting layer, activated 36-nm Bi NPs exhibited an almost-quantitative conversion of CO2 to CO (96.1% FECO), and a mass activity for CO evolution (MACO) of 15.6 mA mg–1, which is three-fold higher than the conventional Bi-ED, at ₋2.0 V (vs Ag/AgCl). Ultimately, this work elucidates the importance of the surface activation for an efficient electrochemical CO2 conversion on metal NPs and paves the way for understanding the CO2 electrochemical reduction mechanism in nonaqueous media.« less

  16. From Molecular to Macroscopic via the Rational Design of a Self-Assembled 3D DNA Crystal

    SciTech Connect

    Zheng, J.; Birktoft, J; Yi, C; Tong, W; Ruojie, S; Constantinou, P; Ginell, S; Chenge, M; Seeman, N

    2009-01-01

    We live in a macroscopic three-dimensional (3D) world, but our best description of the structure of matter is at the atomic and molecular scale. Understanding the relationship between the two scales requires a bridge from the molecular world to the macroscopic world. Connecting these two domains with atomic precision is a central goal of the natural sciences, but it requires high spatial control of the 3D structure of matter1. The simplest practical route to producing precisely designed 3D macroscopic objects is to form a crystalline arrangement by self-assembly, because such a periodic array has only conceptually simple requirements: a motif that has a robust 3D structure, dominant affinity interactions between parts of the motif when it self-associates, and predictable structures for these affinity interactions. Fulfilling these three criteria to produce a 3D periodic system is not easy, but should readily be achieved with well-structured branched DNA motifs tailed by sticky ends2. Complementary sticky ends associate with each other preferentially and assume the well-known B-DNA structure when they do so3; the helically repeating nature of DNA facilitates the construction of a periodic array. It is essential that the directions of propagation associated with the sticky ends do not share the same plane, but extend to form a 3D arrangement of matter. Here we report the crystal structure at 4?Angstroms resolution of a designed, self-assembled, 3D crystal based on the DNA tensegrity triangle4. The data demonstrate clearly that it is possible to design and self-assemble a well-ordered macromolecular 3D crystalline lattice with precise control.

  17. A Rational Approach for Discovering and Validating Cancer Markers in Very Small Samples Using Mass Spectrometry and ELISA Microarrays

    DOE PAGES [OSTI]

    Zangar, Richard C.; Varnum, Susan M.; Covington, Chandice Y.; Smith, Richard D.

    2004-01-01

    Identifying useful markers of cancer can be problematic due to limited amounts of sample. Some samples such as nipple aspirate fluid (NAF) or early-stage tumors are inherently small. Other samples such as serum are collected in larger volumes but archives of these samples are very valuable and only small amounts of each sample may be available for a single study. Also, given the diverse nature of cancer and the inherent variability in individual protein levels, it seems likely that the best approach to screen for cancer will be to determine the profile of a battery of proteins. As a result,more » a major challenge in identifying protein markers of disease is the ability to screen many proteins using very small amounts of sample. In this review, we outline some technological advances in proteomics that greatly advance this capability. Specifically, we propose a strategy for identifying markers of breast cancer in NAF that utilizes mass spectrometry (MS) to simultaneously screen hundreds or thousands of proteins in each sample. The best potential markers identified by the MS analysis can then be extensively characterized using an ELISA microarray assay. Because the microarray analysis is quantitative and large numbers of samples can be efficiently analyzed, this approach offers the ability to rapidly assess a battery of selected proteins in a manner that is directly relevant to traditional clinical assays.« less

  18. Rational design of a carboxylic esterase RhEst1 based on computational analysis of substrate binding

    SciTech Connect

    Chen, Qi; Luan, Zheng -Jiao; Yu, Hui -Lei; Cheng, Xiaolin; Xu, Jian -He

    2015-10-31

    A new carboxylic esterase RhEst1 which catalyzes the hydrolysis of (S)-(+)-2,2-dimethylcyclopropanecarboxylate (S-DmCpCe), the key chiral building block of cilastatin, was identified and subsequently crystallized in our previous work. Mutant RhEst1A147I/V148F/G254A was found to show a 5-fold increase in the catalytic activity. In this work, molecular dynamic simulations were performed to elucidate the molecular determinant of the enzyme activity. Our simulations show that the substrate binds much more strongly in the A147I/V148F/G254A mutant than in wild type, with more hydrogen bonds formed between the substrate and the catalytic triad and the oxyanion hole. The OH group of the catalytic residue Ser101 in the mutant is better positioned to initiate the nucleophilic attack on S-DmCpCe. Interestingly, the "170-179" loop which is involved in shaping the catalytic sites and facilitating the product release shows remarkable dynamic differences in the two systems. Based on the simulation results, six residues were identified as potential "hot-spots" for further experimental testing. Consequently, the G126S and R133L mutants show higher catalytic efficiency as compared with the wild type. In conclusion, this work provides molecular-level insights into the substrate binding mechanism of carboxylic esterase RhEst1, facilitating future experimental efforts toward developing more efficient RhEst1 variants for industrial applications.

  19. Rational design of a carboxylic esterase RhEst1 based on computational analysis of substrate binding

    DOE PAGES [OSTI]

    Chen, Qi; Luan, Zheng -Jiao; Yu, Hui -Lei; Cheng, Xiaolin; Xu, Jian -He

    2015-10-31

    A new carboxylic esterase RhEst1 which catalyzes the hydrolysis of (S)-(+)-2,2-dimethylcyclopropanecarboxylate (S-DmCpCe), the key chiral building block of cilastatin, was identified and subsequently crystallized in our previous work. Mutant RhEst1A147I/V148F/G254A was found to show a 5-fold increase in the catalytic activity. In this work, molecular dynamic simulations were performed to elucidate the molecular determinant of the enzyme activity. Our simulations show that the substrate binds much more strongly in the A147I/V148F/G254A mutant than in wild type, with more hydrogen bonds formed between the substrate and the catalytic triad and the oxyanion hole. The OH group of the catalytic residue Ser101more » in the mutant is better positioned to initiate the nucleophilic attack on S-DmCpCe. Interestingly, the "170-179" loop which is involved in shaping the catalytic sites and facilitating the product release shows remarkable dynamic differences in the two systems. Based on the simulation results, six residues were identified as potential "hot-spots" for further experimental testing. Consequently, the G126S and R133L mutants show higher catalytic efficiency as compared with the wild type. In conclusion, this work provides molecular-level insights into the substrate binding mechanism of carboxylic esterase RhEst1, facilitating future experimental efforts toward developing more efficient RhEst1 variants for industrial applications.« less

  20. Theoretical Studies in Heterogenous Catalysis: Towards a Rational Design of Novel Catalysts for Hydrodesulfurization and Hydrogen Production

    SciTech Connect

    Rodriguez,J.A.; Liu, P.

    2008-10-01

    Traditionally, knowledge in heterogeneous catalysis has come through empirical research. Nowadays, there is a clear interest to change this since millions of dollars in products are generated every year in the chemical and petrochemical industries through catalytic processes. To obtain a fundamental knowledge of the factors that determine the activity of heterogeneous catalysts is a challenge for modern science since many of these systems are very complex in nature. In principle, when a molecule adsorbs on the surface of a heterogeneous catalyst, it can interact with a large number of bonding sites. It is known that the chemical properties of these bonding sites depend strongly on the chemical environment around them. Thus, there can be big variations in chemical reactivity when going from one region to another in the surface of a heterogeneous catalyst. A main objective is to understand how the structural and electronic properties of a surface affect the energetics for adsorption processes and the paths for dissociation and chemical reactions. In recent years, advances in instrumentation and experimental procedures have allowed a large series of detailed works on the surface chemistry of heterogeneous catalysts. In many cases, these experimental studies have shown interesting and unique phenomena. Theory is needed to unravel the basic interactions behind these phenomena and to provide a general framework for the interpretation of experimental results. Ideally, theoretical calculations based on density-functional theory have evolved to the point that one should be able to predict patterns in the activity of catalytic surfaces. As in the case of experimental techniques, no single theoretical approach is able to address the large diversity of phenomena occurring on a catalyst. Catalytic surfaces are usually modeled using either a finite cluster or a two-dimensionally periodic slab. Many articles have been published comparing the results of these two approaches. An important advantage of the cluster approach is that one can use the whole spectrum of quantum-chemical methods developed for small molecules with relatively minor modifications. On the other hand, the numerical effort involved in cluster calculations increases rather quickly with the size of the cluster. This problem does not exist when using slab models. Due to the explicit incorporation of the periodicity of the crystal lattice through the Bloch theorem, the actual dimension of a slab calculation depends only on the size of the unit cell. In practical terms, the slab approach is mainly useful for investigating the behavior of adsorbates at medium and high coverages. Very large unit cells are required at the limit of low to zero coverage, or when examining the properties and chemical behavior of isolated defect sites in a surface. In these cases, from a computational viewpoint, the cluster approach can be much more cost effective than the slab approach. Slab and cluster calculations can be performed at different levels of sophistication: semi-empirical methods, simple ab initio Hartree-Fock, ab initio post-Hartree-Fock (CI, MP2, etc), and density functional theory. Density-functional (DF) based calculations frequently give adsorption geometries with a high degree of accuracy and predict reliable trends for the energetics of adsorption reactions. This article provides a review of recent theoretical studies that deal with the behavior of novel catalysts used for hydrodesulfurization (HDS) reactions and the production of hydrogen (i.e. catalytic processes employed in the generation of clean fuels). These studies involve a strong coupling of theory and experiment. A significant fraction of the review is focused on the importance of size-effects and correlations between the electronic and chemical properties of catalytic materials. The article begins with a discussion of results for the desulfurization of thiophene on metal carbides and phosphides, systems which have the potential to become the next generation of industrial HDS catalysts. Then, systematic studies con

  1. Rationally tuned micropores within enantiopure metal-organic frameworks for highly selective separation of acetylene and ethylene

    SciTech Connect

    Xiang, Sheng-Chang; Zhang, Zhangjing; Zhao, Cong-Gui; Hong, Kunlun; Zhao, Xuebo; Ding, De-Rong; Xie, Ming-Hua; Wu, Chuan-De; Madhab, Das; Gill, Rachel; Thomas, K Mark; Chen, Banglin

    2011-01-01

    Separation of acetylene and ethylene is an important industrial process because both compounds are essential reagents for a range of chemical products and materials. Current separation approaches include the partial hydrogenation of acetylene into ethylene over a supported Pd catalyst, and the extraction of cracked olefins using an organic solvent; both routes are costly and energy consuming. Adsorption technologies may allow separation, but microporous materials exhibiting highly selective adsorption of C{sub 2}H{sub 2}/C{sub 2}H{sub 4} have not been realized to date. Here, we report the development of tunable microporous enantiopure mixed-metal-organic framework (M'MOF) materials for highly selective separation of C{sub 2}H{sub 2} and C{sub 2}H{sub 4}. The high selectivities achieved suggest the potential application of microporous M'MOFs for practical adsorption-based separation of C{sub 2}H{sub 2}/C{sub 2}H{sub 4}.

  2. Feeding Activity, Rate of Consumption, Daily Ration and Prey Selection of Major Predators in John Day Reservoir, 1984 : Annual Report.

    SciTech Connect

    Gray, Gerard A.; United States. Bonneville Power Administration; U.S. Fish and Wildlife Service; National Fishery Research Center

    1986-07-01

    The extent of predation on juvenile salmonids in John Day Reservoir was determined. Salmonids were the single most important food item by weight for northern squawfish (Ptychocheilus oregonensis) in the restricted zones at McNary tailrace and John Day forebay during all sampling periods. Salmonids accounted for 18.1% of the weight in the diet of walleyes (Stizostedion vitreum vitreum) in 1984 which was at least twice that found in previous years. In smallmouth bass (Micropterus dolomieui) salmonids contributed little to their diet whereas for channel catfish (Ictalurus punctatus) fish accounted for 64.1% of the weight in their diet with salmonids responsible for approximately half of this weight. An intensive search of the fisheries literature was conducted to review various fish capture and control techniques which might have potential as predation control measures for the major predators of juvenile salmonids in the Columbia River system. Most prey protection measures were judged to have high potential and direct predator control measures were judged to have moderate or low potential.

  3. Rationalization of Au concentration and distribution in AuNi@Pt core-shell nanoparticles for oxygen reduction reaction

    DOE PAGES [OSTI]

    An, Wei; Liu, Ping

    2015-09-18

    Improving the activity and stability of Pt-based core–shell nanocatalysts for proton exchange membrane fuel cells while lowering Pt loading has been one of the big challenges in electrocatalysis. Here, using density functional theory, we report the effect of adding Au as the third element to enhance the durability and activity of Ni@Pt core–shell nanoparticles (NPs) during the oxygen reduction reaction (ORR). Our results show that the durability and activity of a Ni@Pt NP can be finely tuned by controlling Au concentration and distribution. For a NiAu@Pt NP, the durability can be greatly promoted by thermodynamically favorable segregation of Au tomore » replace the Pt atoms at vertex, edge, and (100) facets on the shell, while still keeping the ORR activity on the active Pt(111) shell as high as that of Ni@Pt nanoparticles. Such behavior strongly depends on a direct interaction with the Ni interlayer. The results not only highlight the importance of interplay between surface strain on the shell and the interlayer–shell interaction in determining the durability and activity but also provide guidance on how to maximize the usage of Au to optimize the performance of core–shell (Pt) nanoparticles. As a result, such understanding has allowed us to discover a novel NiAu@Pt nanocatalyst for the ORR.« less

  4. Rationalization of Au concentration and distribution in AuNi@Pt core-shell nanoparticles for oxygen reduction reaction

    SciTech Connect

    An, Wei; Liu, Ping

    2015-09-18

    Improving the activity and stability of Pt-based coreshell nanocatalysts for proton exchange membrane fuel cells while lowering Pt loading has been one of the big challenges in electrocatalysis. Here, using density functional theory, we report the effect of adding Au as the third element to enhance the durability and activity of Ni@Pt coreshell nanoparticles (NPs) during the oxygen reduction reaction (ORR). Our results show that the durability and activity of a Ni@Pt NP can be finely tuned by controlling Au concentration and distribution. For a NiAu@Pt NP, the durability can be greatly promoted by thermodynamically favorable segregation of Au to replace the Pt atoms at vertex, edge, and (100) facets on the shell, while still keeping the ORR activity on the active Pt(111) shell as high as that of Ni@Pt nanoparticles. Such behavior strongly depends on a direct interaction with the Ni interlayer. The results not only highlight the importance of interplay between surface strain on the shell and the interlayershell interaction in determining the durability and activity but also provide guidance on how to maximize the usage of Au to optimize the performance of coreshell (Pt) nanoparticles. As a result, such understanding has allowed us to discover a novel NiAu@Pt nanocatalyst for the ORR.

  5. Structural Rationalization of a Large Difference in RNA Affinity Despite a Small Difference in Chemistry between Two 2'-O-Modified Nucleic Acid Analogs

    SciTech Connect

    Pattanayek, R.; Sethaphong, L.; Pan, C.; Prhavc, M.; Prakash, T.P.; Manoharan, M.; Egli, M.

    2010-03-08

    Chemical modification of nucleic acids at the 2'-position of ribose has generated antisense oligonucleotides (AONs) with a range of desirable properties. Electron-withdrawing substituents such as 2'-O-[2-(methoxy)ethyl] (MOE) confer enhanced RNA affinity relative to that of DNA by conformationally preorganizing an AON for pairing with the RNA target and by improving backbone hydration. 2'-Substitution of the ribose has also been shown to increase nuclease resistance and cellular uptake via changes in lipophilicity. Interestingly, incorporation of either 2'-O-[2-(methylamino)-2-oxoethyl]- (NMA) or 2'-O-(N-methylcarbamate)-modified (NMC) residues into AONs has divergent effects on RNA affinity. Incorporation of 2'-O-NMA-T considerably improves RNA affinity while incorporation of 2'-O-NMC-T drastically reduces RNA affinity. Crystal structures at high resolution of A-form DNA duplexes containing either 2'-O-NMA-T or 2'-O-NMC-T shed light on the structural origins of the surprisingly large difference in stability given the relatively minor difference in chemistry between NMA and NMC. NMA substituents adopt an extended conformation and use either their carbonyl oxygen or amino nitrogen to trap water molecules between phosphate group and sugar. The conformational properties of NMA and the observed hydration patterns are reminiscent of those found in the structures of 2'-O-MOE-modified RNA. Conversely, the carbonyl oxygen of NMC and O2 of T are in close contact, providing evidence that an unfavorable electrostatic interaction and the absence of a stable water structure are the main reasons for the loss in thermodynamic stability as a result of incorporation of 2'-O-NMC-modified residues.

  6. Rational assembly of Pb(II)/Cd(II)/Mn(II) coordination polymers based on flexible V-shaped dicarboxylate ligand: Syntheses, helical structures and properties

    SciTech Connect

    Yang, Gao-Shan; Liu, Chong-Bo; Liu, Hong; Robbins, Julianne; Zhang, Z. John; Yin, Hong-Shan; Wen, Hui-Liang; Wang, Yu-Hua

    2015-05-15

    Six new coordination polymers, namely, [Pb(L)(H{sub 2}O)] (1), [Pb(L)(phen)] (2), [Pb{sub 2}(L){sub 2}(4,4′-bipy){sub 0.5}] (3), [Cd(L)(phen)] (4), [Cd(L)(4,4′-bipy)]·H{sub 2}O (5) and [Mn(L)(4,4′-bipy)]·H{sub 2}O (6) have been synthesized by the hydrothermal reaction of 2,2′-[hexafluoroisopropylidenebis(p-phenyleneoxy)]diacetic acid (H{sub 2}L) with Pb(II)/Cd(II)/Mn(II) in the presence of ancillary ligands 4,4′-bipyridine (4,4′-bipy) or 1,10-phenanthroline (phen). Complexes 1 and 4–6 exhibit 2-D structures, and complexes 2–3 display 3-D frameworks, of which L{sup 2−} ligands join metal ions to single-stranded helical chains of 1, 3–6 and double-stranded helical chains of 2. Complexes 2 and 3 also contain double-stranded Metal–O helices. Topology analysis reveals that complexes 1 and 4 both represent 4-connected sql net, 2 represents 6-connected pcu net, 3 exhibits a novel (3,12)-connected net, while 5 and 6 display (3,5)-connected gek1 net. The six complexes exhibit two kinds of inorganic–organic connectivities: I{sup 0}O{sup 2} for 1, 4–6, and I{sup 1}O{sup 2} for 2–3. The photoluminescent properties of 4–5 and the magnetic properties of 6 have been investigated. - Graphical abstract: Six new Pb(II)/Cd(II)/Mn(II) coordination polymers with helical structures based on flexible V-shaped dicarboxylate ligand have been synthesized and structurally characterized. Photoluminescent and magnetic properties have been investigated. - Highlights: • Six novel M(II) coordination polymers with 2,2′-[hexafluoroisopropylidenebis(p-phenyleneoxy)]diacetic acid and N-donor ligands. • Complexes 1–6 show diverse intriguing helical characters. • The luminescent properties of complexes 1–5 were investigated. • Complex 6 shows antiferromagnetic coupling.

  7. joe_arm08.ppt

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    clear stable day with tion applied. Should be he curvature, which is eric instability.

  8. A spectral analysis of the domain decomposed Monte Carlo method for linear systems

    SciTech Connect

    Slattery, Stuart R.; Evans, Thomas M.; Wilson, Paul P. H.

    2015-09-08

    The domain decomposed behavior of the adjoint Neumann-Ulam Monte Carlo method for solving linear systems is analyzed using the spectral properties of the linear oper- ator. Relationships for the average length of the adjoint random walks, a measure of convergence speed and serial performance, are made with respect to the eigenvalues of the linear operator. In addition, relationships for the effective optical thickness of a domain in the decomposition are presented based on the spectral analysis and diffusion theory. Using the effective optical thickness, the Wigner rational approxi- mation and the mean chord approximation are applied to estimate the leakage frac- tion of random walks from a domain in the decomposition as a measure of parallel performance and potential communication costs. The one-speed, two-dimensional neutron diffusion equation is used as a model problem in numerical experiments to test the models for symmetric operators with spectral qualities similar to light water reactor problems. We find, in general, the derived approximations show good agreement with random walk lengths and leakage fractions computed by the numerical experiments.

  9. A spectral analysis of the domain decomposed Monte Carlo method for linear systems

    DOE PAGES [OSTI]

    Slattery, Stuart R.; Evans, Thomas M.; Wilson, Paul P. H.

    2015-09-08

    The domain decomposed behavior of the adjoint Neumann-Ulam Monte Carlo method for solving linear systems is analyzed using the spectral properties of the linear oper- ator. Relationships for the average length of the adjoint random walks, a measure of convergence speed and serial performance, are made with respect to the eigenvalues of the linear operator. In addition, relationships for the effective optical thickness of a domain in the decomposition are presented based on the spectral analysis and diffusion theory. Using the effective optical thickness, the Wigner rational approxi- mation and the mean chord approximation are applied to estimate the leakagemore » frac- tion of random walks from a domain in the decomposition as a measure of parallel performance and potential communication costs. The one-speed, two-dimensional neutron diffusion equation is used as a model problem in numerical experiments to test the models for symmetric operators with spectral qualities similar to light water reactor problems. We find, in general, the derived approximations show good agreement with random walk lengths and leakage fractions computed by the numerical experiments.« less

  10. Single-Axis Three-Beam Amplitude Monopulse Antenna-Signal Processing Issues

    SciTech Connect

    Doerry, Armin W.; Bickel, Douglas L.

    2015-05-01

    Typically, when three or more antenna beams along a single axis are required, the answer has been multiple antenna phase-centers, essentially a phase-monopulse system. Such systems and their design parameters are well-reported in the literature. Less appreciated is that three or more antenna beams can also be generated in an amplitude-monopulse fashion. Consequently, design guidelines and performance analysis of such antennas is somewhat under-reported in the literature. We provide discussion herein of three beams arrayed in a single axis with an amplitude-monopulse configuration. Acknowledgements The preparation of this report is the result of an unfunded research and development activity. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administ ration under contract DE-AC04-94AL85000.

  11. Date centerdTimes New Roman

    Energy.gov [DOE] (indexed site)

    ... personnel provide the necessary credentials to successfully administer ESPC ... personnel provide the necessary credentials to very successfully administer ESPCs. ...

  12. nemsoverview_928.vp

    Energy Information Administration (EIA) (indexed site)

    581(2009) The Na tional En ergy Mod el ing Sys tem: An Over view 2009 October 2009 En ergy In for ma tion Ad min is tra tion Of fice of In te grated Anal y sis and Fore cast ing U.S. De part ment of En ergy Wash ing ton, DC 20585 This re port was pre pared by the En ergy In for ma tion Ad min is tra tion, the in de pend ent sta tis ti cal and an a lyt i cal agency within the U.S. De part ment of En ergy. The in for ma tion con tained herein should be at trib uted to the En ergy In for ma tion Ad

  13. ners-cp1-20130402104412

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    581(2009) The Na tional En ergy Mod el ing Sys tem: An Over view 2009 October 2009 En ergy In for ma tion Ad min is tra tion Of fice of In te grated Anal y sis and Fore cast ing U.S. De part ment of En ergy Wash ing ton, DC 20585 This re port was pre pared by the En ergy In for ma tion Ad min is tra tion, the in de pend ent sta tis ti cal and an a lyt i cal agency within the U.S. De part ment of En ergy. The in for ma tion con tained herein should be at trib uted to the En ergy In for ma tion Ad

  14. IDC Re-Engineering Phase 2 Iteration E1 Use Cases.

    SciTech Connect

    Harris, James M.; Carr, Dorthe B.; Coram, Jamie L.

    2016-01-01

    This document contains 21 use cases generated from the model contained in Rational Software Architect.

  15. IDC Re-Engineering Phase 2 Data Model.

    SciTech Connect

    Harris, James M.; Young, Christopher J.; Burns, John F.; Hamlet, Benjamin R.; Montoya, Mark Sinclair; Sandoval, Rudy Daniel; Vickers, James Wallace

    2016-01-01

    This document contains the Data Model generated from the model contained in Rational Software Architect.

  16. Field Communications Control Center Technical Organizational

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    ... and are appropriate authorization credentials (e.g., badges, identifica- tion cards, ... Are all factory default authentication credentials changed after installation? (RRCSS ...

  17. United States

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  18. Relaxation

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    ... wall of tokamak reactors 8 and other possible applica- tions. This investigation is expected to contribute to the un- derstanding of the dynamics of fast tritium or deuterium ...

  19. Predicting Pressure-Dependent Combustion Chemical Reactions

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    ... Chemical Reactions HomeCapabilities, Computational Modeling & Simulation, CRF, Energy, ... in combus-tion and atmospheric chemistry that is expected to benefit auto and ...

  20. Alternative Fuels Data Center (Fact Sheet), Clean Cities, Vehicle...

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    Users can find real-life examples of delivery fleets that run on biodiesel, cities that ... The AFDC provides extensive informa- tion about alternative fuels, including biodiesel, ...

  1. Maintaining System Air Quality; Industrial Technologies Program...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    2 * August 2004 Industrial Technologies Program Suggested Actions * Review compressed air applica- tions and determine the required level of air quality for each. * Review the ...

  2. --No Title--

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    9: Natural Gas (CBECS89.A09) Ques- tion- naire Variable Variable Variable Variable item Description Name Position Format CASEID Building identifier BLDGID4 1- 5 Census region ...

  3. Y NATIOXAL RESFARCH CORPCRATION

    Office of Legacy Management (LM)

    ... From the slices thus taken, ssm- ples will be taken for metallographic examina- tion and vacuum fusion gas analysis for oxygen, nitrogen, hydrogen, and carbcm . hfetallcgraphic and ...

  4. Search results | Department of Energy

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    tion-wind-energy-wind-turbines Download Get Current: Switch on Clean Energy Activity Book Switching on clean energy technologies means strengthening the economy while protecting...

  5. Business Case for Energy Efficient Building Retrofit and Renovation

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    ... ripe for focusing on retrofit and renovation investments that could save energy and money. ... overall project valua- tion. the way this money is allocated to different products, ...

  6. ch_2

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    The Tank Farm consists of storage tanks, tank vaults, interconnecting waste transfer ... several small buildings that contain instrumenta- tion and equipment for the waste tanks. ...

  7. --No Title--

    Gasoline and Diesel Fuel Update

    Central Air Condi- tioners Heat Pumps Indiv- idual Air Condi- tioners District Chilled Water Central Chillers Pack- aged Air Condi- tioning Units Swamp Coolers Other All...

  8. About ASHRAE

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    Weather Data Real- Time Energy Pricing Demand Response Energy Usage Info HVAC Lighting Security Facility Manage- ment Industrial Automa- tion FSGIM Device Energy Manager Load Meter ...

  9. untitled

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    ... The advanced accelerator and X-ray sources developed for this mission are being extended ... viscoelastic fric- tion to its potential energy, we developed a ther- modynamically ...

  10. DOE/EV-0005/27

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    ... tion of uranium in a water sample taken from a core ... This history is based on information given in refs. 1 ... DIGESTION I SOLVENT EXTRACTIONPURIFICATION DENITRATION ...

  11. Single-Column Modeling A Stratiform Cloud Parameterization for...

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    ... variables. where c is a coefficient that depends on the ... The same parameteriza- tions of radiative transfer and ... ratio rv with the condensation-conserved variables T ...

  12. Glossary

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    mixture of relatively volatile hydrocarbons, with or without small quantities of additives, blended to form a fuel suitable for use in spark-ignition engines. Specifica- tions...

  13. LED Color Characteristics

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    a combina- tion of colored LEDs typically red, green, and blue (RGB) are also available. ... triphosphor uorescent, utilize a combination of red-, blue-, and green-emitting phosphors. ...

  14. Environmental Impacts of Increased Hydroelectric Development...

    Energy.gov [DOE] (indexed site)

    ... and oil for electric power production also have impacts on water resources. These include impacts of offshore oil development and oil spills during transporta- tion and refining. ...

  15. N

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    ... Coatings in Fast Neutron and High Temperature Environments of Next Genera- tion Reactors May 2015 Highlights ... gas- and liquid-cooled (sodium, salt, and lead) systems. ...

  16. dudhia-98.pdf

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    wind components, vertical velocity, pressure perturba- tion, temperature, water vapor, ground temperature and microphysical water and ice content variables. It has an upper...

  17. In The News Feed

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    tion-affordable-alternative-platinum

    Microwave heat improves nanostructured molybdenum disulfide catalyst's ability to produce hydrogen.

    October 26, 2015 In The News Feed...

  18. Document

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    ... energy'' means energy produced by solar, wind, biomass, landfill gas, ocean ... and other requirements of present and future genera- tions of Americans; and (l) ...

  19. Scalable Analysis

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    ... computers, work- station clusters, and heterogeneous combinations of these systems. ... For example, if each instrumenta- tion event contained a workflow ID, then a separate file ...

  20. Search results | Department of Energy

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    tion-nevada-teachers-helping-students-learn-about-energy Download Infographics from the 2014 National Geothermal Student Competition With the theme of GeoEnergy is Beautiful, the...

  1. ARQfall99.pgm

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    ... for assembly into radioisotope thermoelectric generators (RTGs), but the LWRHU ... In addi- tion, an aqueous chloride processing line, CLEAR, will use enhanced organic ...

  2. An Assessment

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    ... and applications, Journal of Computational ... et al., The AMP (Advanced MultiPhysics) ... tions, in: 2013 International Conference on Mathematics and Compu- tational ...

  3. PPPL Races Ahead with Fusion Research

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    tion in ITER, an international fusion facility of ... David Gates, a principal research physicist at PPPL and ... Discovery through Advanced Computing (SciDAC) ...

  4. S A N D I A T E C H N O L O G Y A Q UA RT E R LY R E S E A R

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    ... methods relies on smart mathematics for realiza- tion in ... The research relies on atomistic simulations augmented by ... The FUEGO code was developed as part of DOE's Advanced ...

  5. Buildings and Energy in the 1980's (TABLES)

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    1982 End Uses RSE Row Fac- tors All End Uses Space Heating Water Heating Air Conditioning Appliances Building Characteristics Buildings (thou- sand) Consump- tion...

  6. Buildings and Energy in the 1980's (TABLES)

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    1980 End Uses RSE Row Fac- tors All End Uses Space Heating Water Heating Air Conditioning Appliances Building Characteristics Buildings (thou- sand) Consump- tion...

  7. Buildings and Energy in the 1980's (TABLES)

    Energy Information Administration (EIA) (indexed site)

    1981 End Uses RSE Row Fac- tors All End Uses Space Heating Water Heating Air Conditioning Appliances Building Characteristics Buildings (thou- sand) Consump- tion...

  8. --No Title--

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    segregation of elements in the steel matrix.The synergistic deployment of ... under- standing of the structural response of a 9CCr ODS steel to neutron irradia- tion. ...

  9. Microsoft Word - ViArray_Fact_ Sheet_SAND2011-3935P_updated_format...

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    decoupling ude: & Control tion itoring Parts & FPG vironment op ility System boratories ha pplications. services" wi me custom ra aging, test, fa om microele Hard S tructured Ap...

  10. William J. Clinton, 1998

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ... To the extent feasible, remote sensing capabilities shall be developed and applied to this ... identifying the major causes and consequences of degrada- tion of coral reef ecosystems. ...

  11. Frequently Asked Questions about using the New DOE Energy Savings...

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    ... FEDERAL ENERGY MANAGEMENT PROGRAM 2 One example of modern design replacing prior conventional wisdom has occurred with steam plant and boiler decentraliza- tion. Many older ...

  12. X:\\ARM_19~1\\PGS29-47.WPD

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    Clouds are one of the most important moderators of the earth radiation budget and one of ... tions including cloud base height determination and cloud-type occurrence statistics. ...

  13. Agenda for Transitioning the Transportation Sector: Exploring...

    Energy.gov [DOE] (indexed site)

    ... natural gas and erent transport mental Science a e Public Affairs, s Manager, Ho scussion gen in direct co tion applicatio structure rollo ass of stations & uilt to ...

  14. A New Approach to a Lyme Disease Vaccine

    SciTech Connect

    Livey, I.; Dunn, J.; O'Rourke, M.; Traweger, A.; Savidis-Dacho, H.; Crowe, B. A.; Barrett, P. N.; Yang, X.; Luft, B. J.

    2011-02-01

    A single recombinant outer surface protein A (OspA) antigen designed to contain protective elements from 2 different OspA serotypes (1 and 2) is able to induce antibody responses that protect mice against infection with either Borrelia burgdorferi sensu stricto (OspA serotype-1) or Borrelia afzelii (OspA serotype-2). Protection against infection with B burgdorferi ss strain ZS7 was demonstrated in a needle-challenge model. Protection against B. afzelii species was shown in a tick-challenge model using feral ticks. In both models, as little as .03 {micro}g of antigen, when administered in a 2-dose immunization schedule with aluminum hydroxide as adjuvant, was sufficient to provide complete protection against the species targeted. This proof of principle study proves that knowledge of protective epitopes can be used for the rational design of effective, genetically modified vaccines requiring fewer OspA antigens and suggests that this approach may facilitate the development of an OspA vaccine for global use.

  15. WPN 10-9: Amendment to Weatherization Program Notice 09-1b to...

    Energy.gov [DOE] (indexed site)

    Program Notice (WPN) 09-1B, Grant Guidance to Administer the American ... Requirements (Section 4.0) of the Grant Guidance to Administer the American ...

  16. Indications of flow near maximum compression in layered deuterium-tritium implosions at the National Ignition Facility

    DOE PAGES [OSTI]

    Gatu Johnson, M.; Knauer, J. P.; Cerjan, C. J.; Eckart, M. J.; Grim, G. P.; Hartouni, E. P.; Hatarik, R.; Kilkenny, J. D.; Munro, D. H.; Sayre, D. B.; et al

    2016-08-15

    Here, an accurate understanding of burn dynamics in implosions of cryogenically layered deuterium (D) and tritium (T) filled capsules, obtained partly through precision diagnosis of these experiments, is essential for assessing the impediments to achieving ignition at the National Ignition Facility. We present measurements of neutrons from such implosions. The apparent ion temperatures Tion are inferred from the variance of the primary neutron spectrum. Consistently higher DT than DD Tion are observed and the difference is seen to increase with increasing apparent DT Tion. The line-of-sight rms variations of both DD and DT Tion are small, ~150eV, indicating an isotropicmore » source. The DD neutron yields are consistently high relative to the DT neutron yields given the observed Tion. Spatial and temporal variations of the DT temperature and density, DD-DT differential attenuation in the surrounding DT fuel, and fluid motion variations contribute to a DT Tion greater than the DD Tion, but are in a one-dimensional model insufficient to explain the data. We hypothesize that in a three-dimensional interpretation, these effects combined could explain the results.« less

  17. July 2010, Status and Outlook for Nuclear Energy In the United States

    Energy.gov [DOE]

    The U.S. nuclear power industry continues to make pro- gress toward the construction of new nuclear power plants in the United States. Currently, 13 license applica- tions are under active review...

  18. Using PHP format

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    ... the rapidly to the slowly rotating branch of solu- tions is shown as a dotted line. ... Technol. 19, 131 1991. 7 F. Gnesotto, P. Sonato, W. R. Baker et al., Fusion Eng. ...

  19. BPA-2013-01063-FOIA Request

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    Gener ating Station Value Study, including all of its workpapers, author ed by Robert Petty, manager of Power Services Business Opera tions. The draft I have seen was dated as...

  20. LA-11569-M Manual UC-15

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    ... sample well.3 A motor- driven cable moves the source into position where it irradiates the sample for a few seconds, then quickly withdraws the source to a shielded posi- tion. ...

  1. --No Title--

    Energy Information Administration (EIA) (indexed site)

    File 9: Natural Gas and Fuel Oil (cb86f09.csv) Ques- tion- naire Variable Variable Variable Variable item Description Name Position Format Building identifier BLDGID3 1- 5 Adjusted ...

  2. U.S. Energy Information Administration | State Energy Data 2014...

    Annual Energy Outlook

    3 Section 3. Natural Gas Physical units Eight natural gas data series are used to derive the natural gas consump- tion estimates in the State Energy Data System (SEDS). Several of ...

  3. US006753741Bl

    Office of Scientific and Technical Information (OSTI)

    ... separation of about 0.59 ns., Due to tion and dispersion in the nonlinear medium. ... A nonlinear wave crystal and about 10 V for the bi-layer-film waveguides. equation that ...

  4. --No Title--

    Energy Information Administration (EIA) (indexed site)

    File 3: Operating Hours (cb86f03.csv) Ques- tion- naire Variable Variable Variable Variable item Description Name Position Format Building identifier BLDGID3 1- 5 Adjusted weight ...

  5. Mr. John Kieling, Acting Chief Haza

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    or supervision according to a system designed to assure that qualified pers on nel prop erly gather and eva luate th e informa tion submitted . Based on our inquiry of the...

  6. DWIGHT D. EISENHOWER.

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    Saving clause If any provision of this chapter, or the applica- tion thereof to any person or circumstance, shall be held invalid, the validity of the remain- der of the chapter...

  7. OAK RIDGE NATIONAL LABORATORY LABO RATO RY RESULTS OF THE INDEPENDENT...

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    AT 64 TRUDY DRIVE, LODI, NEW JERSEY (LN004V) M. G. Yalcintas C. A. Johnson* *Biology ... In addi- tion, the authors appreciate the manuscript preparation by J. M. Wyrick, Biology ...

  8. O10'I'uf^^ff%

    Office of Legacy Management (LM)

    AT 59 AVENUE C, LODI, NEW JERSEY (LN008V) M. G. Yalcintas C. A. Johnson* *Biology Division ... In addi- tion, the authors appreciate the manuscript preparation by J. M. Wyrick, Biology ...

  9. ORNL/RASA-86/67

    Office of Legacy Management (LM)

    AT 61 TRUDY DRIVE, LODI, NEW JERSEY (LN003V) M. G. Yalcintas C. A. Johnson* *Biology ... In addi- tion, the authors appreciate the manuscript preparation by J. M. Wyrick, Biology ...

  10. OAK RIDGE NATIONAL LABORATORY LABORATORY RESULTS OF THE INDEPENDENT...

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    AT 121 AVENUE F, LODI, NEW JERSEY (LN006V) M. G. Yalcintas C. A. Johnson* *Biology ... In addi- tion, the authors appreciate the manuscript preparation by J. M. Wyrick, Biology ...

  11. OAK RIDGE NATIONAL LABORATORY LABORATORY RESULTS OF THE INDEPENDENT...

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    (LNO05V) M. G. Yalcintas C. A. Johnson* *Biology Division Date of Issue - December 1986 ... In addi- tion, the authors appreciate the manuscript preparation by J. M. Wyrick, Biology ...

  12. ORNL/RASA-86/71

    Office of Legacy Management (LM)

    AT 123 AVENUE F, LODI, NEW JERSEY (LN007V) M. G. Yalcintas C. A. Johnson* *Biology ... In addi- tion, the authors appreciate the manuscript preparation by J. M. Wyrick, Biology ...

  13. ORNL/RASA-86/66

    Office of Legacy Management (LM)

    AT 59 TRUDY DRIVE, LODI, NEW JERSEY (LN002V) M. G. Yalcintas C. A. Johnson* *Biology ... In addi- tion, the authors appreciate the manuscript preparation by J. M. Wyrick, Biology ...

  14. U.S. Global Change Research Program Recommended Citation: Global...

    National Nuclear Security Administration (NNSA)

    ... A billboard on Pohnpei, in the Fed- erated States of Micronesia, encour- ages water conservation in prepara- tion for the 1997 to 1998 El Nio. Extreme Sea-Level Days: Honolulu, ...

  15. Section 52

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    ... This includes the Planck func- tion, the contribution of minor species to absorption in ... this was accomplished by map- ping the Planck function at T5780K in each band ...

  16. Paul Hommert PRESIDENT AND LABORATORIES DIRECTOR

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    The post-Cold War world has presented new and complex issues for America, ranging from ... on clean, renewable solu- tions such as solar, wind, and research into fusion technology. ...

  17. Estimation of changes in insulation resistance with various design parameters of interdigitated wire loops.

    SciTech Connect

    Cordaro, Joseph Gabriel; Jones, Reese E.; Neel, Wiley Christopher

    2015-09-01

    In this report we explore the sensitivities of the insulation resistance between two loops of wire embedded in insulating materials with a simple, approximate model. We discuss limita- tions of the model and ideas for improvements.

  18. Microsoft Word - anthrax3.doc

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    Low pH condi- tions (around pH 5.5) then induce a pre-pore to pore conformational switch that allows the enzymes to enter and eventually kill the host cell. In severe cases, such ...

  19. X:\\L6046\\Data_Publication\\Pma\\current\\ventura\\pma.vp

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    marked the beginning of new federal and state regula- tions governing gasoline. The phase-in period for fed- eral Tier 2 gasoline sulfur standards (with regulations to be fully...

  20. TITLE

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    ... April 4, 1968 (UCRL) (specific.- tions). MSA-23-2184 Well Temt Data, Volune 111, 1968, 1969 (EP1IG) (Specifications). USA-Not Cited Inventory of Wcllr and Springs Witbin a 10-Mile ...

  1. Explanatory Notes

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    complete enumera- tion has the same nonsampling errors as the sample survey. The sampling error, or standard error of the estimate, is a measure of the variability among the...

  2. VOLUME

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    ... source from ioniza- tion of neutral hydrogen (deuterium) and low-Z impuri- ties, a ... current drive, or PPCD) to alter the mag- netic fluctuations and particle transport 12. ...

  3. Section 65

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    American Meteorological Society, Boston, 241-242. Ellingson, R.G., S.H. Shen, and J. Warner, 1994b: Calibra- tion of radiation codes used in climate models: Comparison of...

  4. TECHNOLOGY PROGRAM PLAN

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    ... The exhaust gas of a combus- tion turbine is very hot and ... can be deployed for coal-based ad- vanced integrated ... have a working fuid that contains mostly CO 2 and water. ...

  5. --No Title--

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    File 8: Electricity (cb86f08.csv) Ques- tion- naire Variable Variable Variable Variable ... was completed YRCONC3 31- 32 YRCONC. Electricity supplied ELSUPL3 34- 34 XXSUPL. ...

  6. --No Title--

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    File 8: Electricity (CBECS89.A08) Ques- tion- naire Variable Variable Variable Variable ... 18 YRCONC. P1A Seasonal pricing for electricity ELSEAS4 20- 20 YESNO. P1B Time-of-day ...

  7. DOE/EIA-0207/2 Residential Energy Consumption Survey:

    Gasoline and Diesel Fuel Update

    to keep a log of their fuel purchases and odometer readings for a two-month period. The panel consists of 500 to 1,000 households reporting each month. Separate tabula tions of...

  8. SUBCHAPTER G-NATURAL GAS (ECONOMIC REGULATORY ADMINISTRATION...

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    shall provide a time limit of not less than thirty (30) days from the notice's date of publica- tion in the FEDERAL REGISTER for per- sons to file protests, comments, or a...

  9. Solid-Solution CrCoCuFeNi High-Entropy Alloy Thin Films Synthesized...

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    ... tion up to 800C,1-3 high yield strengths at elevated temperatures,4 high ... lowest surface energy planes are the 111 family of planes, which have been numerically ...

  10. Data Center Energy Efficiency

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Center Energy Efficiency In 2014, data centers in the U.S. con- sumed an estimated 70 billion kWh, 1.8% of total U.S. electricity consump- tion. 1 Thus, it is no surprise that both ...

  11. Tax Incentives

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    tax credits for each kilowatt-hour (kWh) of electricity generated by the facility power projects are eligible to receive 2.3 cents per kWh for the produc - tion of electricity ...

  12. MEMORANDUM TO: FILE

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    ... HISTORl' Li.YITELl ST.-ITES .4R.O' 1 I:iSHZ.% TO.- D. C., I985 tion plants. ... and lubri- cants-needed to operate the plants safelv and efficiently with the highly ...

  13. Search results | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    tion-energy-electricity-consumption-and-efficiency Download An Exploration of Wind Energy & Wind Turbines This unit, which includes both a pre and post test on wind power engages...

  14. November 2007 BWXTymes

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    ... The 9731 Beta calutrons made a signifi cant contribu- tion to the Stable Isotope Program that produced the genesis of the medical radioisotopes used for diagnosis and treatment of ...

  15. Title

    National Nuclear Security Administration (NNSA)

    ... PHOTOGRAPHS TAKEN AUGUST, 1991 BY E G 8 G ENERGY MEASUREMENTS, INC. TION ALLUVIAL FAN ... AT DESIRED CALCULATION INTERVAL LOSS RATE:GREEN AND AMPT INFILTRATION KINEMATIC WAVE: NEW ...

  16. 29 CFR 1910 Occupational Safety and Health Standards

    National Nuclear Security Administration (NNSA)

    ... XVII (7-1-07 Edition) 1910.7 which will be available on the OSHA web site. APPENDIX A ... tion), and synthetic web (nylon, poly- ester, and polypropylene). (b) Definitions. ...

  17. Simplified P N Equations Steven P. Hamilton, Thomas M. Evans

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    Laboratory, 1 Bethel Valley Rd., Oak Ridge, TN 37831 U.S.A. Abstract In this paper we show new solver strategies for the multigroup SP N equa- tions for nuclear reactor analysis. ...

  18. --No Title--

    Energy Information Administration (EIA) (indexed site)

    Flags for HVAC, Lighting and Shell Conservation Features (cb86f14.csv) Ques- tion- ... Flags for HVAC, Lighting, and Shell Conservation Features (cb86f14.csv) (continued) ...

  19. --No Title--

    Energy Information Administration (EIA) (indexed site)

    File 15: Imputation Flags for Lighting and Conservation Features (CBECS89.A15) Ques- tion- ... ZMAINT4 90- 90 ZVAR. Imputed utility conservation program ZUTCNS4 92- 92 ZVAR. Imputed ...

  20. --No Title--

    Energy Information Administration (EIA) (indexed site)

    File 7: HVAC, Lighting, and Building Shell Conservation Features (cb86f07.csv) Ques- tion- ... 52- 52 YESNO. G-3A3 Other HVAC conservation measures OTHVAC3 54- 54 YESNO. G-3A3 ...

  1. --No Title--

    Energy Information Administration (EIA) (indexed site)

    File 7: Lighting and Conservation Features (CBECS89.A07) Ques- tion- naire Variable ... 102 YESNO. H6 Participated in utility conservation pgm UTCNS4 104- 104 YESNO. Adjusted ...

  2. Figure2b.eps

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    ... except the bare Coulomb interaction is replaced by the screened Coulomb interac- tion: W GG ' (q ; ) -1 GG ' (q ; )v(q + G ' ) where v is the bare Coulomb interaction. ...

  3. Microsoft Word - $ASQrpt78020.DOC

    Office of Scientific and Technical Information (OSTI)

    ... Op-tions, National Academies Press, Washington, DC. 2. U.S. Department of Energy (2005) Emission of Green-house Gases in the United States, www.eia.doe.gov oiaf1605flash...

  4. Washington. DC,20585

    Office of Legacy Management (LM)

    you mayihave. ' ,. If you have any ques Dr. Y. Alexander Wil tions, please feel free to call me at 301-903-2531 or liams (301-903UW' of my staff..,, Sincerely, Enclosures...

  5. --No Title--

    Energy Information Administration (EIA) (indexed site)

    File 10: Fuel Oil (CBECS89.A10) Ques- tion- naire Variable Variable Variable Variable ... YRCONC4 17- 18 YRCONC. P3 Total fuel oil tank capacity (gallons) TOTCAP4 20- 25 ...

  6. Dr. Googin and his early days at Y-12, part 8 -- Googin made...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    to do just that. His first "assault" on the chemical process, as he called it in his biography, was on the peroxide precipita- tion. He wanted to make the process handle more...

  7. An Optimized Swinging Door Algorithm for Wind Power Ramp Event...

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    ... An applica- tion of the optimized SDA is provided to ascertain the op- timal parameter of the original SDA. Measured wind power data from the Electric Reliability Council of Texas ...

  8. Energy Technology Solutions: Public-Private Partnerships Transforming...

    Energy.gov [DOE] (indexed site)

    IndustrIal technologIes save energy and Boost competItIveness EnErgy TEchnology SoluTionS public-private partnerships transforming Industry december 2010 "We need a sustained ...

  9. CABLE AOORIs*. HICRONIZER. MOORLblOWN. NEW ,SRIEY

    Office of Legacy Management (LM)

    This provision, how- ever, ls.' subJect:to eny.prlor'arracmont between your Institu- tion and the government with respect to inventions and p?j,tents. ,.: 3,ri 'I :: .:v:ri ...

  10. ch_4

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    based on annual exposure for 1995, 1996, and 1999. Based on 1990 U.S. Census Bureau data, the surrounding popula- tion consisted of approximately 120,000 people within a ...

  11. BPA-2013-00334-FOIA Request

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    but not limited to, the use of existing access roads and tower loca tions on wetlands. Page 3 of 4 The subject of the request: Whether the subject of the requested records...

  12. Word Pro - S1

    Energy Information Administration (EIA) (indexed site)

    Table 1.7 Primary Energy Consumption, Energy Expenditures, and Carbon Dioxide Emissions Indicators Primary Energy Consumption a Energy Expenditures b Carbon Dioxide Emissions c Consump- tion Consump- tion per Capita Consumption per Real Dollar d of GDP e Expendi- tures Expendi- tures per Capita Expenditures as Share of GDP e Expenditures as Share of Gross Output f Emissions Emissions per Capita Emissions per Real Dollar d of GDP e Quadrillion Btu Million Btu Thousand Btu per Chained (2009)

  13. Combined Heat and Power Technology Fact Sheets Series: Fuel Cells

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Fuel cells use an electrochemical process to convert the chemical energy in a fuel to electricity. In contrast to recipro- cating engines and gas turbines, fuel cells generate electric- ity without combusting the fuel. The first practical applica- tion for fuel cells emerged in the 1950s when fuel cells were used to provide onboard power for spacecraft. Fuel cells continue to be used in space exploration, but over the past few decades the technology has migrated to other applica- tions,

  14. The Environmental Style: Writing Environmental Assessments and Impact

    Energy Saver

    NATIONAL AND HOMELAND SECURITY Continued next page Network Interconnectivity The business world is online. So are hackers. The dangers and complica- tions of controlling corporate network access and informa- tion flow from unauthorized users has been a consistent problem since the Inter- net's inception. The guiding principal seems to be that if a programmer can build it, a hacker can destroy it. A virtual back and forth battle of patches and worms, upgrades and viruses has evolved. In addition,

  15. Wind for Schools Project Curriculum Brief (Fact Sheet), Wind And Water Power Program (WWPP)

    WindExchange

    Introduction The U.S. Department of Energy's (DOE's) 20% Wind Energy by 2030 report recommends expanding educa- tion to ensure a trained workforce to meet the projected growth of the wind industry and deployment. Although a few U.S. higher education institu- tions offer wind technology education programs, most are found in community and technical colleges, resulting in a shortage of programs preparing highly skilled graduates for wind industry careers. Further, the United States lags behind

  16. The Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    NATIONAL AND HOMELAND SECURITY Continued next page Network Interconnectivity The business world is online. So are hackers. The dangers and complica- tions of controlling corporate network access and informa- tion flow from unauthorized users has been a consistent problem since the Inter- net's inception. The guiding principal seems to be that if a programmer can build it, a hacker can destroy it. A virtual back and forth battle of patches and worms, upgrades and viruses has evolved. In addition,

  17. Presentations

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    of Clean and Efficient Combustion with Alternative Fuels Author(s): Jacqueline Chen, SNL | Download File: ChenCombustion.pdf | pdf | 30 MB Rational Catalyst Design for...

  18. David L. Rogow | Center for Gas SeparationsRelevant to Clean...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    EFRC research: The focus of my research is on the rational design and synthesis of metal-organic framework (MOF) materials that are tailored with specific functionality for ...

  19. ALSNews Vol. 355

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    the way to the rational design of new and improved versions of the enzymes for basic research and genetic engineering. Read more... Contacts: Jennifer Doudna and Eva Nogales...

  20. Millennium Institute | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    national and global levels. Building a network of supporters and partners across the globe to inspire, promote, endow, and implement rational, integrated planning. Increasing...

  1. Jie Feng | Center for Gas SeparationsRelevant to Clean Energy...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    structure-property relationships of membranes in order to design the new materialsdevices rationally. Employing molecular simulation, mathematical modeling and machine learning ...

  2. Five Los Alamos researchers receive Early Career Awards

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... Gaining a more complete understanding of fundamental chemical bonding properties of relevant actinide ions is essential for rational molecular design to develop efficient ...

  3. PNNL: Center for Molecular Electrocatalysis - Research: An Assessment...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    December 2010 molecular-level understanding of the energetic and mechanistic factors The rational design of improved catalysts requires a detailed molecular-level understanding of ...

  4. Small Molecule Adsorption in Open-Site Metal-Organic Frameworks...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Small Molecule Adsorption in Open-Site Metal-Organic Frameworks: A Systematic Density Functional Theory Study for Rational Design Previous Next List Kyuho Lee, Joshua D. Howe,...

  5. Probing Interfacial Electronic States in CdSe Quantum Dots using...

    Office of Scientific and Technical Information (OSTI)

    Understanding and rationally controlling the properties of nanomaterial surfaces is a ... Chemical modification of the QD surfaces through oxidation resulted in disappearance of ...

  6. Modulation of a membrane lipid lamellar-nonlamellar phase transition...

    Office of Scientific and Technical Information (OSTI)

    be useful as a criterion to assess the quality of lipid carriers and for rational design ... Subject: 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; CARRIERS; CONVERSION; ...

  7. Eden Prairie, Minnesota: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Energy Companies in Eden Prairie, Minnesota Cardinal Glass Industries Independent Natural Resources Inc Rational Energies LLC SUPERVALU Westwood Renewables Wind Energy America Inc...

  8. Search for: All records | SciTech Connect

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... (4) security (4) simulation (4) computer networks ... Facets And Rational Design Of Layered Lithium Transition-metal Oxide ... materials during battery cycling play a crucial ...

  9. Linamar Corporation | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Corporation Jump to: navigation, search Name: Linamar Corporation Place: Ontario, Canada Zip: N1H 1C5 Product: String representation "Linamar Corpora ... ration markets." is...

  10. Clostridium Thermocellum CbhA- Amino acid sequence modified for...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Prior cellulase engineering has focused upon screening small sets of rationally guided ... Significant activity improvement in processive cellulase enzymes on realistic substrates ...

  11. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    ... X-ray diffraction, Raman spectroscopy and NMR. The electrolyte synthesis process was studied and rational approaches for formulating highly active electrolytes were proposed. ...

  12. Model Baseline Fire Department/Fire Protection Engineering Assessment

    Energy.gov [DOE]

    The purpose of the document is to comprehensively delineate and rationalize the roles and responsibilities of the Fire Department and Fire Protection (Engineering).

  13. DOE CONTRACTOR PENSION PLANS

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ... 3 years or after a significant event) including rational for maintaining current asset allocation strategy. (dd) Comparison of budget projections submitted to the Department to ...

  14. Photodynamic therapy for the treatment of osteoarthritis

    DOEpatents

    Trauner, K.; Hasan, T.

    1999-08-24

    A method is disclosed of treating a patient who has osteoarthritic disease by administering a therapeutic composition containing a photoactivatable compound, or a precursor thereof, and administering light of a photoactivating wavelength that activates the compound. 5 figs.

  15. Photodynamic therapy for the treatment of osteoarthritis

    DOEpatents

    Trauner, Kenneth; Hasan, Tayyaba

    1999-01-01

    A method of treating a patient who has osteoarthritic disease by administering a therapeutic composition containing a photoactivatable compound, or a precursor thereof, and administering light of a photoactivating wavelength that activates the compound.

  16. SBOT WASHINGTON PACIFIC NORTHWEST LAB POC Kerry T. Bass Telephone

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ADMINISTATIVE WASTE REMEDIATION Facilities Support Services 561210 Employment Placement Agencies 561311 Temporary Help Services 561320 Professional Employer Organizations ...

  17. SBOT COLORADO GOLDEN FIELD OFFICE POC Karen Downs Telephone

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ADMINISTATIVE WASTE REMEDIATION Facilities Support Services 561210 Employment Placement Agencies 561311 Temporary Help Services 561320 Professional Employer Organizations ...

  18. Southwest Michigan Community Action Agency … Weatherization...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Opportunity under the Department of Human Services was responsible for administering ... governments and various nonprofit organizations participating in the Weatherization ...

  19. Tax Credits, Rebates & Savings | Department of Energy

    Energy.gov [DOE] (indexed site)

    also administers the SCORE Program which provides incentives, energy performance benchmarking, planning workshops, technical assistance, and communications support for...

  20. Treatment of tumors with genetically engineered herpes virus

    DOEpatents

    Weichselbaum, Ralph R; Roizman, Bernard; Whitley, Richard J

    2012-11-27

    Disclosed are methods for treating cancer by administering an effective amount of a modified Herpes simplex virus.

  1. Departmental Directives Program

    Directives, Delegations, and Other Requirements [Office of Management (MA)]

    2006-08-16

    The Order is the primary directive for administering the Department's directives Program. Cancels: DOE O 251.1A

  2. Large Energy Users Program

    Energy.gov [DOE]

    The program is administered by the NJ Board of Public Utilities and is under management by TRC Energy Solutions.

  3. Audit Report: WR-B-98-02 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Western Universities (AWU), a nonprofit organization, administered post-secondary educational programs for DOE through grants and, occasionally, subcontracts. The...

  4. CALIFORNIA LAWRENCE BERKELEY LAB POC David Chen Telephone

    Office of Environmental Management (EM)

    ADMINISTATIVE WASTE REMEDIATION CALIFORNIA LAWRENCE BERKELEY LAB POC David Chen ... Security Systems Services (except Locksmiths) 561621 Hazardous Waste Treatment and ...

  5. Carbon Dioxide Sealing Capacity: Textural or Compositional Controls?

    SciTech Connect

    Cranganu, Constantin; Soleymani, Hamidreza; Sadiqua, Soleymani; Watson, Kieva

    2013-11-30

    This research project is aiming to assess the carbon dioxide sealing capacity of most common seal-rocks, such as shales and non-fractured limestones, by analyzing the role of textural and compositional parameters of those rocks. We hypothesize that sealing capacity is controlled by textural and/or compositional pa-rameters of caprocks. In this research, we seek to evaluate the importance of textural and compositional parameters affecting the sealing capacity of caprocks. The conceptu-al framework involves two testable end-member hypotheses concerning the sealing ca-pacity of carbon dioxide reservoir caprocks. Better understanding of the elements controlling sealing quality will advance our knowledge regarding the sealing capacity of shales and carbonates. Due to relatively low permeability, shale and non-fractured carbonate units are considered relatively imper-meable formations which can retard reservoir fluid flow by forming high capillary pres-sure. Similarly, these unites can constitute reliable seals for carbon dioxide capture and sequestration purposes. This project is a part of the comprehensive project with the final aim of studying the caprock sealing properties and the relationship between microscopic and macroscopic characteristics of seal rocks in depleted gas fields of Oklahoma Pan-handle. Through this study we examined various seal rock characteristics to infer about their respective effects on sealing capacity in special case of replacing reservoir fluid with super critical carbon dioxide (scCO{sub 2}). To assess the effect of textural and compositional properties on scCO{sub 2} maximum reten-tion column height we collected 30 representative core samples in caprock formations in three counties (Cimarron, Texas, Beaver) in Oklahoma Panhandle. Core samples were collected from various seal formations (e.g., Cherokee, Keys, Morrowan) at different depths. We studied the compositional and textural properties of the core samples using several techniques

  6. EMPHASIS(TM)/Nevada Unstructured FEM Implementation Version 2.1.1.

    SciTech Connect

    Turner, C. David; Pointon, Timothy D.; Cartwright, Keith

    2014-08-01

    EMPHASIS TM /NEVADA is the SIERRA/NEVADA toolkit implementation of portions of the EMP HASIS TM code suite. The purpose of the toolkit i m- plementation is to facilitate coupling to other physics drivers such as radi a- tion transport as well as to better manage code design, implementation, co m- plexity, and important verification and validation processes. This document describes the theory and implementation of the unstructured finite - element method solver , associated algorithms, and selected verification and valid a- tion . Acknowledgement The author would like to recognize all of the ALEGRA team members for their gracious and willing support through this initial Nevada toolkit - implementation process. Although much of the knowledge needed was gleaned from document a- tion and code context, they were always willing to consult personally on some of the less obvious issues and enhancements necessary.

  7. CG Q/v

    Office of Legacy Management (LM)

    Therefore, the 5.4 alphas per dis&ntf ration of thorium-232 is summed in the units of dpm ... Cc-xaction has been aade to',;ive disk&ration rata of thorium-232. Bui' lding 21 A wal ...

  8. EOS Interpolation and Thermodynamic Consistency

    SciTech Connect

    Gammel, J. Tinka

    2015-11-16

    As discussed in LA-UR-08-05451, the current interpolator used by Grizzly, OpenSesame, EOSPAC, and similar routines is the rational function interpolator from Kerley. While the rational function interpolator is well-suited for interpolation on sparse grids with logarithmic spacing and it preserves monotonicity in 1-d, it has some known problems.

  9. Analysis of the neutron time-of-flight spectra from inertial confinement fusion experiments

    DOE PAGES [OSTI]

    Hatarik, R.; Sayre, D. B.; Caggiano, J. A.; Phillips, T.; Eckart, M. J.; Bond, E. J.; Cerjan, C.; Grim, G. P.; Hartouni, E. P.; Knauer, J. P.; et al

    2015-11-12

    For a long time, neutron time-of-flight diagnostics been used to characterize the neutron spectrum produced by inertial confinement fusion experiments. The primary diagnostic goals are to extract the d+t→n+α (DT) and d+d→n+³He (DD) neutron yields and peak widths, and the amount DT scattering relative to its unscattered yield, which is also known as the down-scatter ratio (DSR). These quantities are used to infer yield weighted plasma conditions, such as ion temperature (Tion) and cold fuel areal density. We explain such novel methodologies used to determine neutron yield, apparent Tion and DSR.

  10. S A V A N N A H R I V E R S I T E

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Excerpts from "Strengthening Energy Security through Federal Partnerships" 67 ENE RGY The Military Engineer * No. 676 The need to shrink depen dence on fos- sil fuels is not a new conce pt in the na- tion's energy discus sion, nor is the need to invest in clean, renew able energy . But the challe nge of how to deliver solar, bioma ss, wind, wave, geothe rmal and other power genera tion techno logies in a cost effecti ve, large-s cale mann er-an d meet the chang - ing energy deman ds of

  11. Superconductivity Program Overview High-Temperature Superconductivity

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    SuperconducTiviTy program haS Three FocuS areaS: SuperconducTiviTy applicaTionS Developing HTS-based electric power equipment such as transmission and distribution cables and fault current limiters Second-generaTion Wire developmenT Developing high-performance, low-cost, second- generation HTS wire at long lengths STraTegic reSearch Supporting fundamental research activities to better understand relationships between the microstructure of HTS materials and their ability to carry large electric

  12. Microsoft Word - summer.doc

    Energy Information Administration (EIA) (indexed site)

    b trac ting fro m th e da ily a ve rag e hig h te m p e ra tu res fo r th e la st 10 y ea rs a n am o un t e qu al to tw ice a n estim ate o f the stan da rd de via tion for h igh...

  13. IoT Interoperability at Bosch

    Energy.gov [DOE] (indexed site)

    Acquire d S oftwa re Innova tions , 2008 Bus ine s s proce s s ma na ge me nt Cloud-ba s e d IoT s olutions Acquiring P ros ys t (a nnounce d Fe brua ry 2015) P...

  14. The Honorable Aaron Thompson.

    Office of Legacy Management (LM)

    I lper ic. iiii SkIi lriili e 1 S.' ;e le ;hiT ' si viec I s'ii '0 ic It lb it i te L 1. ess In rma tjo ion I r Ai 'uil el a the I or .I . nls ,3"' .in : ,tion .' 'n is " eir ' ...

  15. Proposed Wild Horse Pass Substation Option

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    LAK E C ITY, U T PAN EL 2 ELEC TR IC ITY D ISTR IBU TION AN D EN D -U SE: H OW D O W E MAN AGE C H ALLEN GES AN D OPPOR TU N ITIES? AP R I L 2 5 , 2 0 1 6 Gila River Indian ...

  16. NUCLEAR EXPLOSIONS - PEACEFUI APPLICATIONS PROJECT WUL 1 SON

    Office of Legacy Management (LM)

    NUCLEAR EXPLOSIONS - PEACEFUI APPLICATIONS PROJECT WUL 1 SON F I N A L OPERATIONAL WAB$OACTIVI TY REPORT PRODUCT1 ON TESTS FEBRUARY 1972 PEACEFUL APPLICATIONS DIVISION NEVADA OPER4TIONS OFFICE This page intentionally left blank TABLE OF CONTENTS Subject Page N o . Abstract . . . . . . . . . . . . . . . . . . . . . . . . . . i i . . . . . . . . . . . . . . . . . . . . . . Acknowledgements i i i . . . . . . . . . . . . . . . . . . . . . . I . Introduction 1 I1 . F i r s t Production Test . . . . .

  17. Transforming PV Installations Toward Dispatchable, Schedulable...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Toward disPaTchable, schedulable energy soluTions MIChAEl MIllS-PrICE, SEGIS-AC ProGrAM MAnAGEr, AE SolAr EnErGy A B C N SATCON518kw1 B2+2 Cap Bank 7825S PHC870 6896 Aout Ain ...

  18. las

    Office of Legacy Management (LM)

    ... Net confining p r e s s u r e ( N C P ) , which is the oil p r e s s u r e minus mean gas ... C o r e Laboratories, Inc., Measurements for Austral Oil Co., private communica- tion ...

  19. Tax Credits, Rebates & Savings | Department of Energy

    Energy.gov [DOE] (indexed site)

    Sustainable Energy Utility- Business Energy Rebate Program The District of Columbia's Sustainable Energy Utility (DCSEU) administers the Business Energy Rebate Program. Rebates are...

  20. Home Energy Score: Information for Interested Organizations

    Energy.gov [DOE]

    Home Energy Score Partners include various types of organizations (e.g., utilities, state agencies, local governments, non-profits, contractor associations) that administer the delivery of the...

  1. SBOT TEXAS PANTEX PLANT POC Brad Beck Telephone

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    PANTEX PLANT POC Brad Beck Telephone (806) 477-6192 Email bbrack@pantex.com ADMINISTATIVE WASTE REMEDIATION Facilities Support Services 561210 Executive Search Services 561312 ...

  2. ORISE: Research Experiences

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Research Experiences Research Experiences The Oak Ridge Institute for Science and Education (ORISE) administers more than 150 science education programs on behalf of the U.S....

  3. Tax Credits, Rebates & Savings | Department of Energy

    Energy.gov [DOE] (indexed site)

    Solar Water Heat, Solar Space Heat, Solar Thermal Electric, Solar Thermal Process Heat, Solar Photovoltaics Energy Loan Program The Missouri Energy Loan Program, administered by...

  4. Tax Credits, Rebates & Savings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    pending approval, Other EE, Commercial Refrigeration Equipment City of Chicago- Small Business Improvement Fund SomerCor 504 Inc. administers the Small Business Improvement Fund...

  5. Tax Credits, Rebates & Savings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Roofs, LED Lighting, Commercial Refrigeration Equipment City of Chicago- Small Business Improvement Fund SomerCor 504 Inc. administers the Small Business Improvement Fund...

  6. Tax Credits, Rebates & Savings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    EE, Fuel Cells using Renewable Fuels, Tankless Water Heater City of Chicago- Small Business Improvement Fund SomerCor 504 Inc. administers the Small Business Improvement Fund...

  7. Tax Credits, Rebates & Savings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    EE, Food Service Equipment, Reflective Roofs, LED Lighting City of Chicago- Small Business Improvement Fund SomerCor 504 Inc. administers the Small Business Improvement Fund...

  8. Tax Credits, Rebates & Savings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Processing and Manufacturing Equipment, CustomOthers pending approval, Wind (Small) Energy Loan Program The Missouri Energy Loan Program, administered by the Division of...

  9. Tax Credits, Rebates & Savings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Tax Credits, Rebates & Savings Tax Credits, Rebates & Savings City of Chicago- Small Business Improvement Fund SomerCor 504 Inc. administers the Small Business Improvement Fund...

  10. Tax Credits, Rebates & Savings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Insulation, Windows, Doors, Roofs, Other EE, Reflective Roofs City of Chicago- Small Business Improvement Fund SomerCor 504 Inc. administers the Small Business Improvement Fund...

  11. Tax Credits, Rebates & Savings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Direct-Use, Other Distributed Generation Technologies City of Chicago- Small Business Improvement Fund SomerCor 504 Inc. administers the Small Business Improvement Fund...

  12. Tax Credits, Rebates & Savings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Controls, LED Lighting, Commercial Refrigeration Equipment City of Chicago- Small Business Improvement Fund SomerCor 504 Inc. administers the Small Business Improvement Fund...

  13. Tax Credits, Rebates & Savings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Reflective Roofs, Commercial Refrigeration Equipment City of Chicago- Small Business Improvement Fund SomerCor 504 Inc. administers the Small Business Improvement Fund...

  14. Tax Credits, Rebates & Savings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    DuctAir sealing, Building Insulation, Other EE, LED Lighting City of Chicago- Small Business Improvement Fund SomerCor 504 Inc. administers the Small Business Improvement Fund...

  15. Tax Credits, Rebates & Savings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Thermostats, DuctAir sealing, Building Insulation, Other EE City of Chicago- Small Business Improvement Fund SomerCor 504 Inc. administers the Small Business Improvement Fund...

  16. Tax Credits, Rebates & Savings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    CustomOthers pending approval, Tankless Water Heater City of Chicago- Small Business Improvement Fund SomerCor 504 Inc. administers the Small Business Improvement Fund...

  17. Tax Credits, Rebates & Savings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    MeasuresWhole Building, Wind (Small), Reflective Roofs City of Chicago- Small Business Improvement Fund SomerCor 504 Inc. administers the Small Business Improvement Fund...

  18. Tax Credits, Rebates & Savings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    (Small), Anaerobic Digestion, Fuel Cells using Renewable Fuels City of Chicago- Small Business Improvement Fund SomerCor 504 Inc. administers the Small Business Improvement Fund...

  19. Lineman

    Energy.gov [DOE]

    There are several Lineman positions available with Bonneville Power Administation in different locations throughout Washington and Oregon. A successful candidate in this position will perform...

  20. Home Energy Score API User: United Illuminating Company and Eversource

    Energy.gov [DOE]

    The United Illuminating Company and Eversource, administering conservation, and load management programs funded by the Connecticut Energy Efficiency Fund, are Home Energy Score Partners. Home...

  1. Tax Credits, Rebates & Savings | Department of Energy

    Energy.gov [DOE] (indexed site)

    Green Home Loan Program The loan program is administered through the city's Community Action Agency. Apply by calling the Agency at (405) 232-0199. Eligibility: Residential...

  2. Tax Credits, Rebates & Savings | Department of Energy

    Energy.gov [DOE] (indexed site)

    Wind (Small), Food Service Equipment, Commercial Refrigeration Equipment Small Business Pollution Prevention Assistance Account Loan Program The program is administered by the PA...

  3. Tax Credits, Rebates & Savings | Department of Energy

    Energy.gov [DOE] (indexed site)

    Motors, Motor VFDs, CustomOthers pending approval, Other EE, Wind (Small) Small Business Pollution Prevention Assistance Account Loan Program The program is administered by the PA...

  4. Tax Credits, Rebates & Savings | Department of Energy

    Energy.gov [DOE] (indexed site)

    conditioners, Energy Mgmt. SystemsBuilding Controls, Motor VFDs, Other EE Small Business Pollution Prevention Assistance Account Loan Program The program is administered by the PA...

  5. http://www.epa.gov/fedrgstr/eo/eo13175.htm

    National Nuclear Security Administration (NNSA)

    ... regulations administered by Indian tribal governments, the Federal Government shall grant Indian tribal governments the maximum administrative discretion possible. (c) When ...

  6. U.S. Department of Energy, Hanford Site

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Act (ESA) with regard to listed steelhead and Chinook salmon while the United States Fish and Wildlife Service (FWS) is responsible for administering the ESA with regard to...

  7. MassSAVE (Gas)- Residential Rebate Program

    Office of Energy Efficiency and Renewable Energy (EERE)

    MassSAVE, through Gas Networks, organizes residential conservation services for programs administered by Massachusetts electric companies, gas companies and municipal aggregators. These utilities...

  8. Tax Credits, Rebates & Savings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    in 1990 using oil overcharge funds. The program, administered by the Nebraska Energy Office, makes available low-interest loans for... Eligibility: Commercial, Construction,...

  9. Flood Disaster Protection Act of 1973 | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Flood Disaster Protection Act of 1973Legal Abstract The National Flood Insurance Program (NFIP) is administered primarily under two statutes: the National Flood...

  10. Tax Credits, Rebates & Savings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Motor VFDs, CustomOthers pending approval, Other EE, Wind (Small) Small Business Pollution Prevention Assistance Account Loan Program The program is administered by the PA...

  11. Building Energy Code

    Office of Energy Efficiency and Renewable Energy (EERE)

    The Rhode Island Building Code Standards Committee adopts, promulgates and administers the state building code. Compliance is determined through the building permit and inspection process by local...

  12. NW Natural (Gas)- Residential Energy Efficiency Rebate Program

    Office of Energy Efficiency and Renewable Energy (EERE)

    Energy Trust of Oregon administers energy efficiency rebate programs for both residential and commercial customers of NW Natural in Washington. Interested customers can see the program website...

  13. Alternative Fuels Data Center

    Alternative Fuels and Advanced Vehicles Data Center

    Natural Gas and Propane Vehicle Grant Program The Tennessee Department of Environment and Conservation's Office of Energy Programs administers the Natural Gas and Propane Vehicle ...

  14. Alternative Fuels Data Center

    Alternative Fuels and Advanced Vehicles Data Center

    Natural Gas Vehicle (NGV) and Fueling Infrastructure Grants The Texas Commission on Environmental Quality (TCEQ) administers the NGV Grant Program (Program) as part of the Texas ...

  15. Tax Credits, Rebates & Savings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Solar Photovoltaics Tax Credits, Rebates & Savings Tax Credits, Rebates & Savings Energy Loan Program The Missouri Energy Loan Program, administered by the Division of Energy in...

  16. FirstEnergy (MetEdison, Penelec, Penn Power, West Penn Power)- Residential Energy Efficiency Programs

    Office of Energy Efficiency and Renewable Energy (EERE)

    First Energy as a parent company administers the energy efficiency program for Metropolitan Edition (Met-Ed), Pennsylvania Electric (Penelec), Pennsylvania Power (Penn Power), and West Penn Power. ...

  17. Tax Credits, Rebates & Savings | Department of Energy

    Energy.gov [DOE] (indexed site)

    Enterprise Development Authority (Figtree PACE)- Statewide PACE Program FIGTREE Energy Financing is administering a Property Assessed Clean Energy (PACE) financing program...

  18. Deputy Director, Office of Civil Rights & Equal Opportunity

    Energy.gov [DOE]

    The U.S. Department of Energy (DOE) Office of Civil Rights and Equal Opportunity (OCREO) is responsible for developing and administering Departmental policies, practices, and procedures under...

  19. Tax Credits, Rebates & Savings | Department of Energy

    Energy.gov [DOE] (indexed site)

    a pilot loan program, CT Solar Loan, to provide homeowners with 15-year loans for solar PV equipment. The loans are administered... California Solar Initiative- Low-Income...

  20. MassSAVE (Electric)- Commercial New Construction/Major Renovation Program

    Office of Energy Efficiency and Renewable Energy (EERE)

    MassSAVE organizes commercial, industrial, and institutional conservation services for programs administered by Massachusetts electric companies, gas companies and municipal aggregators. These...

  1. Tax Credits, Rebates & Savings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    was created in 1990 using oil overcharge funds. The program, administered by the Nebraska Energy Office, makes available low-interest loans for... Eligibility: Commercial,...

  2. Appropriations Questions | Department of Energy

    Energy.gov [DOE] (indexed site)

    Officer. What are the guidelines for expenditure for third-party administered loan loss reserve (LLR) programs funded with SEP ARRA and EECBG ARRA funds? Loan loss reserve...

  3. Tax Credits, Rebates & Savings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Biomass Tax Credits, Rebates & Savings Tax Credits, Rebates & Savings Energy Loan Program The Missouri Energy Loan Program, administered by the Division of Energy in the...

  4. Clean Cities: Clean Fuels Ohio coalition

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    where he was charged with administering programs for AmeriCorps members. Andrew holds dual Bachelor's degrees in History and Comparative Religious Studies from Wright State...

  5. Tax Credits, Rebates & Savings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Motors Tax Credits, Rebates & Savings Tax Credits, Rebates & Savings Energy Loan Program The Missouri Energy Loan Program, administered by the Division of Energy in the Missouri...

  6. Retrofit Incentives for Multifamily Buildings | Department of...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Note that each DOE Weatherization grantee - state, tribe or territory - administers Weatherization based on the unique characteristics and priorities of their service territory. If ...

  7. VNCLIP | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    includes a recipient-executed component that will be administered by the Ministry of Natural Resources and Environment (MONRE). VNCLIP will be dedicated to building capacity on...

  8. Laws & Legal Resources | Department of Energy

    Energy.gov [DOE] (indexed site)

    Library Books | Credit: GC Photographer Daniel Zazueta Library Books | Credit: GC Photographer Daniel Zazueta Looking for... Online Legal Resources Laws DOE Administers Guidance &...

  9. Method of imaging the heart using copper-64 citrate

    DOEpatents

    Crook, James E.

    1988-01-01

    A method of imaging the heart to provide a distinct image using positron emission tomography comprises administering copper-64 citrate and a compatible carrier.

  10. ORISE Science Education Programs: How to Work with Us

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    How to Work with Us The Oak Ridge Institute for Science and Education (ORISE) administers high-quality, experience-based research programs to facilitate a scientifically literate...

  11. Tax Credits, Rebates & Savings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    State Government Tax Credits, Rebates & Savings Tax Credits, Rebates & Savings Energy Loan Program The Missouri Energy Loan Program, administered by the Division of Energy in...

  12. Tax Credits, Rebates & Savings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Local Government Tax Credits, Rebates & Savings Tax Credits, Rebates & Savings Energy Loan Program The Missouri Energy Loan Program, administered by the Division of Energy in...

  13. Tax Credits, Rebates & Savings | Department of Energy

    Energy.gov [DOE] (indexed site)

    pending approval, Other EE, Food Service Equipment, Tankless Water Heater NW Natural (Gas)- Residential Energy Efficiency Rebate Program Energy Trust of Oregon administers...

  14. Tax Credits, Rebates & Savings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Building Insulation, Windows, Doors, Siding, Roofs, Wind (Small) NW Natural (Gas)- Residential Energy Efficiency Rebate Program Energy Trust of Oregon administers...

  15. Tax Credits, Rebates & Savings | Department of Energy

    Energy.gov [DOE] (indexed site)

    approval, Other EE, LED Lighting, Commercial Refrigeration Equipment Small Business Pollution Prevention Assistance Account Loan Program The program is administered by the PA...

  16. Tax Credits, Rebates & Savings | Department of Energy

    Energy.gov [DOE] (indexed site)

    Energy Mgmt. SystemsBuilding Controls, Motor VFDs, Other EE Small Business Pollution Prevention Assistance Account Loan Program The program is administered by the PA...

  17. Tax Credits, Rebates & Savings | Department of Energy

    Energy.gov [DOE] (indexed site)

    Commercial Energy Efficiency Rebate Program Hawaii Energy is a ratepayer-funded conservation and efficiency program administered by Leidos Engineering, LLC under contract with the...

  18. California Enterprise Development Authority (Figtree PACE) -...

    Energy.gov [DOE] (indexed site)

    Administrator FIGTREE Energy Financing Website http:www.figtreecompany.com State California Program Type PACE Financing Summary FIGTREE Energy Financing is administering a...

  19. Tax Credits, Rebates & Savings | Department of Energy

    Energy.gov [DOE] (indexed site)

    NW Natural (Gas)- Business Energy Efficiency Rebate Program Energy Trust of Oregon administers energy efficiency rebate programs for both residential and commercial customers of NW...

  20. Tax Credits, Rebates & Savings | Department of Energy

    Energy.gov [DOE] (indexed site)

    NW Natural (Gas)- Residential Energy Efficiency Rebate Program Energy Trust of Oregon administers energy efficiency rebate programs for both residential and commercial customers of...

  1. Alternative Fuels Data Center

    Alternative Fuels and Advanced Vehicles Data Center

    Loans The Oregon Department of Energy administers the State Energy Loan Program (SELP) which offers low-interest loans for qualified projects. Eligible alternative fuel projects...

  2. Westlands Water District | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Westlands Water District Jump to: navigation, search Name: Westlands Water District Place: California Sector: Solar Product: Water district in central California which administers...

  3. 02-2012 | netl.doe.gov

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... Ranalli, a postdoctoral researcher from Virginia Tech, is participating in a 3-year research fellowship program at NETL administered by ORISE and managed by Oak Ridge Associated ...

  4. U.S. Department of Energy Carlsbad Field Office Waste Isolation...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Magnum Minerals LLC of Hereford, Texas. As part of the agreement, the Carlsbad Soil and Water Conservation District (CSWCD) will sign and administer the contract with Magnum...

  5. Tax Credits, Rebates & Savings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Programmable Thermostats Tax Credits, Rebates & Savings Tax Credits, Rebates & Savings Energy Loan Program The Missouri Energy Loan Program, administered by the Division of...

  6. Administration | U.S. DOE Office of Science (SC)

    Office of Science (SC)

    Employee Development and Training We administer the Training Program for the Office of ... Freedom of Information (FOIA) requests; employee separation guidance upon resignation...

  7. EIS-0472: Final Programmatic Environmental Impact Statement ...

    Energy.gov [DOE] (indexed site)

    for DOE's Uranium Leasing Program, under which DOE administers tracts of land in western Colorado for exploration, development, and the extraction of uranium and vanadium ...

  8. Oklahoma City- Green Home Loan Program

    Energy.gov [DOE]

    The loan program is administered through the city's Community Action Agency. Apply by calling the Agency at (405) 232-0199.

  9. Alternative Fuels Data Center

    Alternative Fuels and Advanced Vehicles Data Center

    Fuel Vehicle (AFV) and Fueling Infrastructure Loans The Nebraska Energy Office administers the Dollar and Energy Saving Loan Program, which makes low-cost loans available for a ...

  10. Nicholas Balthaser

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    analyst at Wells Fargo Bank. Before joining the Storage Systems Group Nick managed Linux compute platforms in the Computational Systems Group and administered FreeBSD systems...

  11. Residential Clean Energy Grant Program

    Energy.gov [DOE]

    Maryland's Residential Clean Energy Grant Program, administered by the Maryland Energy Administration (MEA), provides financial incentives to homeowners that install solar water-heating, solar...

  12. ORISE: ORISE is accepting applications for the 2015 U.S. Department...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    for students majoring in homeland security-related science, technology, engineering and mathematics (HS-STEM) disciplines. The program is administered for DHS through ORISE,...

  13. Microsoft PowerPoint - FY2016 Senior Professional Performance...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ... Ability to acquire and administer human, financial, material, and information resources in a manner that instills public trust and accomplishes the program's mission Building ...

  14. Sustainable Energy Utility (Electric & Gas)- Business Energy Rebate Program

    Office of Energy Efficiency and Renewable Energy (EERE)

    The District of Columbia's Sustainable Energy Utility (DCSEU) administers the Business Energy Rebate Program. Rebates are available to businesses and institutions for the installation of energy...

  15. Science Museum

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    New Mexico State University and is responsible for administering the department and teaching U.S., New Mexico and public history courses. - 2 - Hunner will talk about the...

  16. Microsoft Word - CRADA Agreement Boilerplate Approved 6-2014...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    B. "Contracting Officer" means the DOE employee administering the Contractor's DOE ... F. "Intellectual Property" means patents, trademarks, copyrights, mask works, Protected ...

  17. Microsoft Word - Short Form CRADA Agreement Boilerplate Approved...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    C. "Contracting Officer" means the DOE employee administering the Contractor's DOE ... CRADA. H. "Intellectual Property" means patents, trademarks, copyrights, mask works, ...

  18. RAPID/Roadmap/15-NV-a | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    BETA About Bulk Transmission Geothermal Hydropower Solar Tools Contribute Contact Us Air Quality Permit - Operating Permit (15-NV-a) The federal Clean Air Act is administered...

  19. Tax Credits, Rebates & Savings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    created in 1990 using oil overcharge funds. The program, administered by the Nebraska Energy Office, makes available low-interest loans for... Eligibility: Commercial,...

  20. DOE - NNSA/NFO -- News & Views NRDS Nuclear Rocket

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    The Atomic Energy Commission (AEC) and the National Aeronautics and Space Administration (NASA) Space Nuclear Propulsion Office jointly administered the test area --subsequently ...

  1. Introduction

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    The Atomic Energy Commission (AEC) and the National Aeronautics and Space Administration's (NASA) Space Nuclear Propulsion Office jointly administered the test area, later called ...

  2. Mass Save (Electric)- Large Commercial Retrofit Program

    Energy.gov [DOE]

    Mass Save organizes commercial, industrial, and institutional conservation services for programs administered by Massachusetts electric companies, gas companies and municipal aggregators. These...

  3. Mass Save (Electric)- Small Business Direct Install Program

    Energy.gov [DOE]

    Mass Save organizes commercial, industrial, and institutional conservation services for programs administered by Massachusetts electric companies, gas companies and municipal aggregators. These...

  4. Mass Save (Electric)- Residential Energy Efficiency Programs

    Energy.gov [DOE]

    Mass Save organizes residential energy conservation services for programs administered by Massachusetts electric companies, gas companies, and municipal aggregators. Rebates for various energy...

  5. Tax Credits, Rebates & Savings | Department of Energy

    Energy.gov [DOE] (indexed site)

    meet the efficiency and installation requirements stated by New Mexico Gas Company. New Mexico Gas Company also administers the SCORE Program which provides incentives, energy...

  6. Tax Credits, Rebates & Savings | Department of Energy

    Energy.gov [DOE] (indexed site)

    Reflective Roofs, Tankless Water Heater Commercial Energy Efficiency Rebate Program Hawaii Energy is a ratepayer-funded conservation and efficiency program administered by...

  7. Tax Credits, Rebates & Savings | Department of Energy

    Energy.gov [DOE] (indexed site)

    Pollution Prevention Assistance Account Loan Program The program is administered by the PA Department of Environmental Protection and the PA Department of Community and Economic...

  8. Tax Credits, Rebates & Savings | Department of Energy

    Energy.gov [DOE] (indexed site)

    Small Business Pollution Prevention Assistance Account Loan Program The program is administered by the PA Department of Environmental Protection and the PA Department of Community...

  9. Alternative Fuels Data Center

    Alternative Fuels and Advanced Vehicles Data Center

    Grants The Pennsylvania Department of Environmental Protection administers the Natural Gas Vehicle Grant Program, which provides funding to eligible municipal and commercial fleets...

  10. Washington Closure Hanford System Engineer Program FY2010 Annual Report

    SciTech Connect

    J.N. Winters

    2010-11-02

    This report is a summary of the assessments of the vital safety systems (VSS) that are administered under WCH’s system engineer program.

  11. Tax Credits, Rebates & Savings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Combined Heat & Power Tax Credits, Rebates & Savings Tax Credits, Rebates & Savings Energy Loan Program The Missouri Energy Loan Program, administered by the Division of Energy...

  12. Use Of Vitamin B6 To Mitigate Visual Field Deficits Associated With The Use Of Gabaergic Drugs In Mannals

    DOEpatents

    Ashby, Jr., Charles R.

    2004-03-30

    The invention provides a method for treating visual field defects in a mammal in need thereof by administering an effective amount of vitamin B6 to the mammal.

  13. RAPID/Roadmap/19-CA-b | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    for appropriating surface water in California. The California State Water Resources Control Board (SWRCB) has complete authority in administering the permit process. Developers...

  14. lustre-tools-llnl

    SciTech Connect

    Morrone, C.

    2010-12-17

    lustre-tools-llnl is a small set of commands that are helpful for using and administering a lustre file system.

  15. Utah R850-27 Geothermal Steam | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    in Utah outlining the authority for the Utah School and Institutional Trust Lands Administration (UTLA) to administer trust land in the state, including the leasing of trust land...

  16. RAPID/Roadmap/3-UT-e | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Lease (Utah Trust Lands) (3-UT-e) The Utah School and Institutional Trust Lands Administration (UTLA) administers the sale, exchange, and lease of state school and institutional...

  17. Tax Credits, Rebates & Savings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Building Insulation Tax Credits, Rebates & Savings Tax Credits, Rebates & Savings Energy Loan Program The Missouri Energy Loan Program, administered by the Division of Energy in...

  18. EAGA Partnership | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Kingdom Zip: NE2 1DB Sector: Efficiency Product: Employee-owned trust installing insulation, cavity wall and loft insulation, and allocating and administering energy efficiency...

  19. DOL: Role in EEOICPA - Part B and Part E | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Description DOL is tasked with administering the EEOICPA, both Parts B and E. Part B covers current and former workers who have been diagnosed with cancer, chronic beryllium ...

  20. EIS-0293: Amended Record of Decision

    Energy.gov [DOE]

    Conveyance and Transfer of Certain Land Tracts Administered by the Department of Energy and Located at Los Alamos National Laboratory, Los Alamos and Santa Fe Counties, New Mexico

  1. Trestle Bay Restoration Project Draft Feasibility Study and Draft

    Energy.gov [DOE] (indexed site)

    Local Operating Procedures for Endangered Species to Administer Stream Restoration and Fish Passage Improvement Actions Authorized or Carried Out by the U.S. Army Corps of...

  2. Endangered Species Act | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    species and the ecosystems upon which they depend. It is administered by the U.S. Fish and Wildlife Service and the Commerce Department's National Marine Fisheries Service...

  3. Retooling and Manufacturing Program Guidance Using State Energy...

    Energy.gov [DOE] (indexed site)

    sponsoring energy efficiency and renewable energy projects involving retooling and manufacturing that are funded by the 2009 Recovery Act and administered through the DOE State...

  4. Tax Credits, Rebates & Savings | Department of Energy

    Energy.gov [DOE] (indexed site)

    (Small), Food Service Equipment, Commercial Refrigeration Equipment Small Business Pollution Prevention Assistance Account Loan Program The program is administered by the PA...

  5. Tax Credits, Rebates & Savings | Department of Energy

    Energy.gov [DOE] (indexed site)

    Food Service Equipment, Commercial Refrigeration Equipment Small Business Pollution Prevention Assistance Account Loan Program The program is administered by the PA Department of...

  6. Tax Credits, Rebates & Savings | Department of Energy

    Energy.gov [DOE] (indexed site)

    Building Insulation, Windows, Doors, Other EE, LED Lighting Small Business Pollution Prevention Assistance Account Loan Program The program is administered by the PA Department of...

  7. Tax Credits, Rebates & Savings | Department of Energy

    Energy.gov [DOE] (indexed site)

    CustomOthers pending approval, Other EE, Wind (Small) Small Business Pollution Prevention Assistance Account Loan Program The program is administered by the PA Department of...

  8. U.S. Department of Energy Partners with the Next Generation Lighting Industry Alliance

    Energy.gov [DOE]

    Administered by the National Electrical Manufacturers Association (NEMA), the Next Generation Lighting Industry Alliance (NGLIA) is an alliance of for-profit lighting manufacturers formed to...

  9. Recycle My Fridge

    Energy.gov [DOE]

    The Illinois Municipal Electricity Agency (IMEA), a nonprofit organization representing 33 Illinois municipal and co-op electricity providers, administers the Illinois Recycle My Fridge program in...

  10. EIS-0293: Record of Decision

    Office of Energy Efficiency and Renewable Energy (EERE)

    Conveyance and Transfer of Certain Land Tracts Administered by the Department of Energy and Located at Los Alamos National Laboratory, Los Alamos and Santa Fe Counties, New Mexico

  11. Tax Credits, Rebates & Savings | Department of Energy

    Energy.gov [DOE] (indexed site)

    Residential Energy Efficiency Programs MassSAVE organizes residential conservation services for programs administered by Massachusetts electric companies, gas companies and...

  12. Workplace Charging Challenge: Workplace PEV Ride and Drive |...

    Energy.gov [DOE] (indexed site)

    Workplace Charging Challenge: Workplace PEV Ride and Drive Workplace plug-in electric vehicle ... Manage vehicle liability by requesting that car companies administer waivers and send ...

  13. Tax Credits, Rebates & Savings | Department of Energy

    Energy.gov [DOE] (indexed site)

    Energy is a ratepayer-funded conservation and efficiency program administered by Leidos Engineering, LLC under contract with the Hawaii Public Utilities Commission serving the...

  14. Microsoft Word - M-2 WTP Contract Section H - Conformed Thru...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    (or subcontracts thereunder) administered by the DOE, which are subject to the Davis-Bacon Act, in the classifications set forth in the Hanford Site Stabilization Agreement...

  15. Alternative Fuels Data Center

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    (OED) administers, offers grants ranging from 25,000 to 100,000 for community energy conservation efforts, including projects that deploy AFVs in fleets. Eligible entities ...

  16. DOE/EA-1494 Final Environmental Assessment for Activities Using

    National Nuclear Security Administration (NNSA)

    ... of Conservation and Natural Resources, Division of Environmental Protection, Bureau of Air Pollution Control (BAPC) administers the Clean Air Act within the state of Nevada. ...

  17. DOE/EA… 1334

    National Nuclear Security Administration (NNSA)

    ... The regulatory program for the CAA is administered within the state of Nevada by the Nevada Division of Environmental Protection (NDEP), Bureau of Air Pollution Control. Portions ...

  18. Alternative Fuels Data Center

    Alternative Fuels and Advanced Vehicles Data Center

    Electric Vehicle Supply Equipment (EVSE) Incentives - San Joaquin Valley The San Joaquin Valley Air Pollution Control District (SJVAPCD) administers the Charge Up Program, which ...

  19. Alternative Fuels Data Center

    Alternative Fuels and Advanced Vehicles Data Center

    The California Air Resources Board and the State Energy Resources Conservation and Development Commission will develop and administer the Program. Remanufactured and retrofitted ...

  20. Building Energy Code

    Energy.gov [DOE]

    The California Building Standards Commission (BSC) is responsible for administering California's building standards adoption, publication, and implementation. Since 1989, the BSC has published tr...

  1. INS-L-10-03

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    After a thorough review of the facts, including a review of e-mails, conducting a significant number of personal interviews, administering signedsworn statements, and making ...

  2. Table Definitions, Sources, and Explanatory Notes

    Annual Energy Outlook

    ... into five districts by the Petroleum Administration for Defense in 1950. These districts were originally defined during World War II for purposes of administering oil allocation. ...

  3. Table Definitions, Sources, and Explanatory Notes

    Annual Energy Outlook

    into five districts by the Petroleum Administration for Defense in 1950. These districts were originally defined during World War II for purposes of administering oil allocation. ...

  4. Clean Cities: Norwich Clean Cities coalition

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    administering and reporting on various programs and grant awards, including the Connecticut Clean Fuels Program and the recent Congestion Mitigation and Air Quality (CMAQ)...

  5. Tax Credits, Rebates & Savings | Department of Energy

    Energy.gov [DOE] (indexed site)

    Commercial Retrofit Program MassSAVE organizes commercial, industrial, and institutional conservation services for programs administered by Massachusetts electric companies, gas...

  6. Gamma Log At Lightning Dock Geothermal Area (Witcher, 2006) ...

    OpenEI (Open Energy Information) [EERE & EIA]

    Usefulness useful DOE-funding Unknown Exploration Basis Part of the Geothermal Resource Evaluation and Definition (GRED) Program administered by DOE-AAO under Cooperative...

  7. Well Deepening At Lightning Dock Geothermal Area (Witcher, 2006...

    OpenEI (Open Energy Information) [EERE & EIA]

    Usefulness useful DOE-funding Unknown Exploration Basis Part of the Geothermal Resource Evaluation and Definition (GRED) Program administered by DOE-AAO under Cooperative...

  8. Compound and Elemental Analysis At Lightning Dock Geothermal...

    OpenEI (Open Energy Information) [EERE & EIA]

    Usefulness useful DOE-funding Unknown Exploration Basis Part of the Geothermal Resource Evaluation and Definition (GRED) Program administered by DOE-AAO under Cooperative...

  9. Isotope Geothermometry At Lightning Dock Geothermal Area (Witcher...

    OpenEI (Open Energy Information) [EERE & EIA]

    Usefulness useful DOE-funding Unknown Exploration Basis Part of the Geothermal Resource Evaluation and Definition (GRED) Program administered by DOE-AAO under Cooperative...

  10. Isotopic Analysis- Fluid At Lightning Dock Geothermal Area (Witcher...

    OpenEI (Open Energy Information) [EERE & EIA]

    Usefulness useful DOE-funding Unknown Exploration Basis Part of the Geothermal Resource Evaluation and Definition (GRED) Program administered by DOE-AAO under Cooperative...

  11. Cation Geothermometers At Lightning Dock Geothermal Area (Witcher...

    OpenEI (Open Energy Information) [EERE & EIA]

    Usefulness useful DOE-funding Unknown Exploration Basis Part of the Geothermal Resource Evaluation and Definition (GRED) Program administered by DOE-AAO under Cooperative...

  12. Tax Credits, Rebates & Savings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Solar Water Heat Tax Credits, Rebates & Savings Tax Credits, Rebates & Savings Energy Loan Program The Missouri Energy Loan Program, administered by the Division of Energy in...

  13. United States Department of the Interior - Directors Order 53...

    OpenEI (Open Energy Information) [EERE & EIA]

    Regulatory GuidanceGuideHandbook Abstract This Director's Order sets forth the policies and procedures for administering special park uses on NPS lands. Author USDOI...

  14. Audit Report: IG-0568 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    and administer systems or networks by using government or privately-owned computer equipment. Generally, remote access to the Department's networks is achieved through dial-in ...

  15. Alternative Fuels Data Center

    Alternative Fuels and Advanced Vehicles Data Center

    ... The CR also provides 10 million to administer the program. ARRA and the Energy and Water Development and Related Agencies Appropriations Act of 2010 also appropriated funding for ...

  16. Grievance Policy and Procedures

    Directives, Delegations, and Other Requirements [Office of Management (MA)]

    2006-02-02

    This Order provides general requirements, instructions, and responsibilities for administering the Department of Energy's administrative grievance system. Supersedes DOE O 3771.1.

  17. DOE - Office of Legacy Management -- Blue

    Office of Legacy Management (LM)

    Mill Tailings Radiation Control Act (UMTRCA). The site transferred to the Office of Legacy Management in 2003 and is administered under the provisions of a general NRC license. ...

  18. DOE - Office of Legacy Management -- Lbar

    Office of Legacy Management (LM)

    Mill Tailings Radiation Control Act (UMTRCA). The site transferred to the Office of Legacy Management in 2003 and is administered under the provisions of a general NRC license. ...

  19. DOE - Office of Legacy Management -- Edge

    Office of Legacy Management (LM)

    Mill Tailings Radiation Control Act (UMTRCA). The site transferred to the Office of Legacy Management in 2003 and is administered under the provisions of a general NRC license. ...

  20. DOE - Office of Legacy Management -- Sherwood

    Office of Legacy Management (LM)

    Mill Tailings Radiation Control Act (UMTRCA). The site transferred to the Office of Legacy Management in 2003 and is administered under the provisions of a general NRC license. ...

  1. DOE - Office of Legacy Management -- Shirley

    Office of Legacy Management (LM)

    The site transferred to the Office of Legacy Management in 2003 and is administered under the provisions of a general NRC license. The site requires routine inspection and ...

  2. Alternative Fuels Data Center

    Alternative Fuels and Advanced Vehicles Data Center

    and Fueling Infrastructure Grants The New Mexico Energy, Minerals, and Natural Resources Department administers the Clean Energy Grants Program, which provides grants for projects ...

  3. Alternative Fuels Data Center

    Alternative Fuels and Advanced Vehicles Data Center

    Loans The Oregon Department of Energy administers the State Energy Loan Program (SELP) which offers low-interest loans for qualified projects. Eligible alternative fuel projects ...

  4. Alternative Fuels Data Center

    Alternative Fuels and Advanced Vehicles Data Center

    Vehicle (AFV) Voucher Program The Maryland Energy Administration (MEA) administers the Maryland Freedom Fleet Voucher (FFV) Program, which provides vouchers for the purchase of new ...

  5. Alternative Fuels Data Center

    Alternative Fuels and Advanced Vehicles Data Center

    Vehicle (AFV) and Fueling Infrastructure Loans The Nebraska Energy Office administers the Dollar and Energy Saving Loan Program, which makes low-cost loans available for a variety ...

  6. Alternative Fuels Data Center

    Alternative Fuels and Advanced Vehicles Data Center

    Infrastructure Grants The Maryland Energy Administration administers the Maryland Alternative Fuel Infrastructure Program (AFIP), which provides grants to develop public access ...

  7. Mass Save (Gas)- Residential Rebate Program

    Energy.gov [DOE]

    Mass Save, through Gas Networks, organizes residential conservation services for programs administered by Massachusetts gas companies. These gas providers include Columbia Gas of Massachusetts,...

  8. Tax Credits, Rebates & Savings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Program, administered by the Division of Energy in the Missouri Department of Economic Development (DED), is available for energy efficiency and renewable energy projects......

  9. Business Energy Conservation Revolving Loan Fund

    Energy.gov [DOE]

    The New Hampshire Business Finance Authority (BFA) administers a revolving loan program for businesses and non-profit organizations to finance energy efficiency improvements. The terms are flexible...

  10. Become a Corporate Host | Robotics Internship Program

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    of potential interns. ORISE, managed by ORAU on behalf of DOE, will administer the umbrella structure of this program. The basic components of the EERE Robotics Program include:...

  11. Tax Credits, Rebates & Savings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energy Loan Program, administered by the Division of Energy in the Missouri Department of Economic Development (DED), is available for energy efficiency and renewable energy...

  12. Energy Loan Program

    Office of Energy Efficiency and Renewable Energy (EERE)

    The Missouri Energy Loan Program, administered by the Division of Energy in the Missouri Department of Economic Development (DED), is available for energy efficiency and renewable energy projects...

  13. UDAC Meeting - September 2012 | Department of Energy

    Office of Environmental Management (EM)

    Decision Support for Ultra-Deepwater Drilling PDF icon EPAct Complementary Program - Extreme Offshore PDF icon RPSEA Administered Cost Share Research Overview: Ultra-Deepwater ...

  14. Alternative Fuels Data Center

    Alternative Fuels and Advanced Vehicles Data Center

    Clean Transportation Fuel Standards The Oregon Department of Environmental Quality (DEQ) administers the Oregon Clean Fuels Program (Program), which requires fuel producers and ...

  15. Alternative Fuels Data Center

    Alternative Fuels and Advanced Vehicles Data Center

    Air Quality Improvement Program Funding - Ventura County The Ventura County Air Pollution Control District (VCAPCD) administers the Clean Air Fund, which provides grants for ...

  16. Intriguing DNA Editor Has a Structural Trigger

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    the way to the rational design of new and improved versions of Cas9 enzymes for basic research and genetic engineering. Genetic Plug-Ins Software plug-ins make it relatively simple...

  17. CX-008929: Categorical Exclusion Determination

    Energy.gov [DOE]

    Fundamental Investigations and Rational Design of Durable, High-Performance Cathode Materials CX(s) Applied: B3.6 Date: 08/23/2012 Location(s): Georgia Offices(s): National Energy Technology Laboratory

  18. Overcoming Hydrocarbon Inhibition on Pd-based Diesel Oxidation...

    Energy.gov [DOE] (indexed site)

    Discusses results of a project focused on overcoming hydrocarbon inhibition on Pd-based diesel oxidation catalysts by using a rational catalyst design approach. deer11kapur.pdf ...

  19. Human choice and climate change. Volume 3: The tools for policy analysis

    SciTech Connect

    Rayner, S.; Malone, E.L.

    1997-12-31

    Foreward: Preface; Introduction; Economic activity and analysis; Games and simulations; Decision analysis and rational action; Reasoning by analogy; Integrated assessment modeling; and Sponsoring organizations, International Advisory Board, and project participants.

  20. LL Pm

    Office of Legacy Management (LM)

    ... average release rate of 3 pCim's, and (2) . increase the annual average Rn-222 cancer ration at or above any location outside the boundary of the cant minated area by more ...

  1. Herbert Goldstein, 1962 | U.S. DOE Office of Science (SC)

    Office of Science (SC)

    Print Text Size: A A A FeedbackShare Page Reactors: For significant contributions to reactor physics and to nuclear cross sections, and for leadership in establishing a rational ...

  2. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    ... Rationalization of Au concentration and distribution in AuNi@Pt core-shell nanoparticles ... of Ni@Pt core-shell nanoparticles (NPs) during the oxygen reduction reaction (ORR). ...

  3. Microsoft Word - Draftv2.doc

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    momentum input TP-8.2 Investigation of rational q effects on ITB formation and expansion 7 PEP-7 Pedestal width analysis by dimensional edge identity experiments PEP-10...

  4. AOT & LANSCE The Pulse February 2011

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    1 Los Alamos National Laboratory * Est. 1943 The Pulse-Newsletter of the Los Alamos Neutron Science Center and Accelerator Operations and Technology Division I N S I D E 2 From Alex's Desk 3 VersAtile AutomAteD sAmple chAnger For texture meAsure- ments At lAnsce neutron DiFFrAc- tion sheDs light on crystAl structure oF hyDrogen storAge mAteriAl 4 Workshop spot- lights lujAn center neutron scAttering expertise 5 smArts exAmines irrADiAtion-inDuceD eVolution oF DeFormA- tion mechAnisms lAnsce

  5. Fuel Efficient Stoves for Darfur Camps of Internally DisplacedPersons - Report of Field Trip to North and South Darfur, Nov. 16 -Dec.17, 2005

    SciTech Connect

    Galitsky, Christina; Gadgil, Ashok; Jacobs, Mark; Lee, Yoo-Mi

    2006-02-01

    Approximately 2.2 million internally displaced persons (''IDPs'') in Darfur are living in dense camps scattered in arid areas with low fuelwood productivity. Unsustainable harvesting of fuelwood by the IDPs has created ever increasing zones of denudation, that now (in November 2005) have reached several kilometers from the camp boundaries. Leaving the safety of the camps to fetch fuelwood from farther and farther away imposes great risk and hardship on the IDP women. Three different metal fuel efficient stove (''FES'') designs were tested in Darfur IDP camps for their suitability to substantially reduce the fuelwood needs of IDPs. The mud-and-dung ''ITDG'' stoves being promoted under the current FES program were also examined and tested. A modified design of the ITDG mud-and-dung stove, ''Avi'', was developed, built and tested. Systematic informal surveys of IDP households were undertaken in North and South Darfur to understand the household parameters related to family size, food, fuel, cooking habits, cooking pots, expenditure on fuel, and preferences related to alternative ways to spend time/money if fuel could be saved. Surveys found that a significant fraction of families are missing meals for lack of fuel (50% in South Darfur, and 90% in the North Darfur camps visited by the mission). About 60% of women in South Darfur, and about 90% of women in North Darfur camps purchase fuelwood. Selling some of the food rations to purchase fuel to cook meals was significant (40%) in South Darfur and has become common (80%) in North Darfur. The LBNL mission found that two of the metal stoves and the mud-and-dung Avi can significantly reduce fuelwood consumption using the same fuel, pot, cooking methods, and food ingredients used by Darfur IDPs. The most suitable design for Darfur conditions would be a modified ''Tara'' stove. With training of the cooks in tending the fire, this stove can save 50% fuel for the IDPs. The stove costs less than $10 (US) to produce in Darfur

  6. NREL Delivers In-Home HVAC Efficiency Testing Solutions (Fact Sheet), Building America: Technical Highlight, Building Technologies Program (BTP)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Delivers In-Home HVAC Efficiency Testing Solutions Researchers at the National Renewable Energy Laboratory (NREL) have recently developed two simple in-home efficiency test methods that can be used by technicians, researchers, or interested homeowners to verify the correct opera- tion and energy efficiency of a home's air conditioning and heating equipment. An efficiency validation method for mini-split heat pumps (MSHPs)-highly efficient refrigerant-based air conditioning and heating systems

  7. NRELs Energy-Saving Technology for Air Conditioning Cuts Peak Power Loads Without Using Harmful Refrigerants (Fact Sheet), NREL (National Renewable Energy Laboratory)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    DEVAP Slashes Peak Power Loads Desiccant-enhanced evaporative (DEVAP) air-condi- tioning will provide superior comfort for commercial buildings in any climate at a small fraction of the elec- tricity costs of conventional air-conditioning equip- ment, releasing far less carbon dioxide and cutting costly peak electrical demand by an estimated 80%. Air conditioning currently consumes about 15% of the electricity generated in the United States and is a major contributor to peak electrical demand on

  8. Improving Catalyst Efficiency in Bio-Based Hydrocarbon Fuels (Fact Sheet), NREL Highlights in Science, NREL (National Renewable Energy Laboratory)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    New study determines the effect of catalyst structure on product yields and coking during vapor phase upgrading of biomass pyrolysis products. Converting biomass, an abun- dant and renewable resource, into liquid transportation fuels has attracted significant atten- tion because of depleting fossil fuel reserves and associated environmental concerns. In the quest for sustainable and eco-friendly fuel alternatives, much research is focusing on improving the properties of bio-oil. Scientists at

  9. Federal Alternative Motor Fuels Programs Fifth Annual Report to Congress - 1996

    Alternative Fuels and Advanced Vehicles Data Center

    Abstract This annual report to Congress presents the current status of the U.S. Department of Energy's alterna- tive fuel vehicle demonstration and performance tracking programs being conducted across the country in accordance with the Energy Policy and Conservation Act (42 U.S.C. 6374, et seq.). These programs, which comprise the most compre- hensive data collection effort ever undertaken on alternative transporta- tion fuels and alternative fuel vehi- cles, are beginning their sixth year. This

  10. Industry and Education Experts Work Together to Establish Alternative Fuel Vehicle (AFV) Technician Training Standards

    Alternative Fuels and Advanced Vehicles Data Center

    s more and more AFVs find their places in the transporta- tion industry, the need for qualified technicians to service these vehicles continues to grow. To help meet this need, transportation indus- try and education experts are working together to develop standards for AFV technician training, standards that will serve as a valuable tool for AFV technician training programs now and in the future. Background Section 411 of the Energy Policy Act of 1992 (EPAct) requires that the U.S. Department

  11. Departm

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Kie ling, Acting Bureau Chief Hazardous Waste Bureau New Mexico Environment Department 2905 Rodeo Park Drive East, Building 1 San ta Fe, New Mexico 87 505-6303 MAY 2 4 2012 Subject: Notification of Class 1 Permit Modifica tion to the Hazard ous Waste Facility Permit, Number: NM4890139088-TSDF Dear Mr. Kieling: Enclosed is the fo llowing Class 1 Permit Modification Notification : * Update Emergency Coordinator Add ress and Telephone Numbers We certify under penalty of law that this document and

  12. CATALYTIC PROMOTION OF THE ADSORPTION OF VANADIUM ON AN ANIONIC EXCHANGE RESIN

    DOEpatents

    Bailes, R.H.; Ellis, D.A.

    1958-08-26

    An improvement in the process for the recovery of vanadium from acidic phosphatic solutions is presented. In this process the vanadium is first oxidized to the pentavaleat state, and is then separated by contacting such solutions with an anion exchange resin whereby adsorption of the complexed pentavalent vanadium is effected. The improvement lies in the fact that adsorp tion of the vanadium complex by the anion exchange resin is promoted and improved by providing fiuoride ions in solution to be contacted.

  13. Graduation Day

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Graduation Day Tevatron Impact Symposium Keynote Lisa Randall Graduation * grad*u*a*tion * [graj-oo-ey-shuhn * noun 1. an act of graduating; the state of being graduated. * 2. the ceremony of conferring degrees or diplomas, as at a college or school. * Today we celebrate the impact and legacy of the Tevatron * Both in terms of science and in its influence on technology and creative scientific thinking Legacy * Momentous time in particle physics. - Transition. - Many eyes on LHC. * But really

  14. BT16 Agricultural Residues and Biomass Energy Crops Factsheet

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    agricultural sector. POLYSYS was developed to simulate changes in eco- nomic policy, agricultural management, and natural resource conditions, as well as to estimate how agricultural producers may respond to new agricultural market opportunities, such as new demand for biomass, while considering the impact on other non-energy crops. For this analysis, the data in POLYSYS is anchored in a USDA-published baseline of yield, acreage, and price projec- tions for the agriculture sector, which are

  15. Operations & Maintenance Best Practices Guide: Release 3.0

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    C � Resources � Appendix C Resources for Energy and Facilities Professionals The references and resources provided below are by no means all-inclusive. The listed organiza- tions are not endorsed by the authors of this guide and are provided for your information only. To locate additional resources, the authors of this guide recommend contacting relevant trade groups, databases, and the world-wide web. Organizations American Society for Healthcare Engineering (ASHE) � Website: www.ashe.org

  16. Technical Sessions J. E. Penner Lawrence Livermore National Laboratory

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Penner Lawrence Livermore National Laboratory Livermore, California 94550 The stated goal of the Atmospheric Radiation Measure- ment (ARM) program is to improve the treatment of radia- tion in general circulation models (GCMs). The means for doing so will be to compare model-predicted radiative fluxes with measured fluxes at four to six permanent sites. The measured fluxes will characterize the fluxes expected on the scale of a GCM grid box. Because aerosol optical depths at solar wavelengths

  17. Final Environmental Impact Statement

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    EIS - 0097-F c f ` f= �c J m s= Final Environmental Impact Statement BONNEVILLE POWER ADMINISTRATION TRANSMISSION FACILITIES VEGETATION MANAGEMENT PROGRAM U.S. Department of Energy August 1983 Appendices albLbfp= J MMVTJc= Responsible Official: tfiif^j= ^K= s^rde^k= Assistant Secretary for Environmental Protection. Safety, and Emergency Prepafedness Final Environmental Impact Statement BONNEVILLE POWER ADM IN ISTRA TION TRANSMISSION FACILITIES VEGETATION MANAGEMENT PROGRAM U.S. Department of

  18. Flexible Hybrid Friction Stir Joining Technology

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Flexible Hybrid Friction Stir Joining Technology Improved Efficiency and Flexibility through the Development of Hybrid Friction Stir Joining Technology Welding is one of the most important and widely used fabrica- tion technologies in modern industry. Traditional fusion welding processes (e.g. arc welding and laser welding) require signifcant heat inputs and frequently lead to property deterioration, such as cracking and porosity during solidifcation. Friction Stir Welding (FSW) is a solid-state

  19. Fuel Cell Financing for Tax-Exempt Entities

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Financing for Tax-Exempt Entitities Facilitating deployments by structuring energy service contracts to include the Energy Investment Tax Credit. Introduction The Energy Investment Tax Credit (ITC) 1 can help reduce the cost of installing a fuel cell system. While Department of Treasury regulations prevent tax-exempt entities, e.g., not-for-proft organiza- tions, from directly taking advantage of tax benefts for property that they own, the Internal Revenue Code (IRC) and Treasury regulations

  20. Neutron-induced fission measurements at the time-of-flight facility nELBE

    DOE PAGES [OSTI]

    Kögler, T.; Beyer, R.; Junghans, A. R.; Massarczyk, R.; Schwengner, R.; Wagner, A.

    2015-05-18

    Neutron-induced fission of ²⁴²Pu is studied at the photoneutron source nELBE. The relative fast neutron fission cross section was determined using actinide fission chambers in a time-of-flight experiment. A good agreement of present nuclear data with evalua- tions has been achieved in the range of 100 keV to 10 MeV.

  1. International Training Course on Physical Protection (ITC-25) Report.

    SciTech Connect

    Overholt, Michelle Jungst

    2015-06-01

    The goal of this evaluation repor t is to provide the informa tion necessary to improve the effectiveness of the ITC provided to the In ternational Atomic Energy Agency Member States. This report examines ITC-25 training content, delivery me thods, scheduling, and logistics. Ultimately, this report evaluates whether the course pr ovides the knowledge and skills necessary to meet the students' needs in the protection of nuclear materials and facilities.

  2. San Francisco Operations Office

    Office of Legacy Management (LM)

    San Francisco Operations Office 1333 Broadway Oakland, California 94612 Dr. Joseph 0. Ward, Chief Radiological Health Section Department of Health Services 744 P Street Sacramento, California, 95814 SUBJECT: Certification Docket of Gilman Hall Dear Dr. Ward: The Department of Energy (DOE) has completed and reviewed the remedial ac- tions of Gilman Hall located at the University of California, Berkeley, California. Based on this review, DOE certifies that the condition of Gilman Hall is

  3. A Potential Role for Immersion Freezing in Arctic Mixed-Phase Stratus

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Potential Role for Immersion Freezing in Arctic Mixed-Phase Stratus Gijs de Boer, Edwin W. Eloranta, Tempei Hashino, and Gregory J. Tripoli The University of Wisconsin - Madison (1) Introduction Ice formation appears to a dominant factor controlling the lifecycle of Arctic mixed-phase clouds. To date, our understanding of ice formation in these long-lasting cloud structures does not explain the formation of observed ice amounts. Particularly puzzling are observa- tions taken from the 2004

  4. old.new.factsheets.indd

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    DARHT Dual-Axis Radiographic Hydrodynamic Test Facility At the Los Alamos National Laboratory (LANL), the Dual-Axis Radiographic Hydrodynamic Test Facility, or DARHT, supports a critical component of LANL's primary mission: to ensure the safety, security, and effectiveness of nuclear weapons in our na- tion's stockpile. Los Alamos scientists built DARHT, the world's most powerful x-ray machine, to analyze mockups of nuclear weapons. The DARHT Facility DARHT consists of two linear induction

  5. Patterns of Convection in the Tropical Western Pacific

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Patterns of Convection in the Tropical Western Pacific J. H. Mather Pacific Northwest National Laboratory Richland, Washington Introduction Convection is ubiquitous throughout the maritime continent region. However, the frequency of convec- tion is not uniform. While much of this region does not experience seasons to the same degree as one finds in mid-latitudes, the annual cycle of the sun's passage does have a large impact on convection throughout the maritime continent and the tropical

  6. QDP-JIT/PTX: A QDP++ Implementation for CUDA-Enabled GPUs

    SciTech Connect

    Winter, Frank T.; Edwards, Robert G.

    2014-11-01

    These proceedings describe briefly the QDP-JIT/PTX framework for lattice field theory calcula- tions on the CUDA architecture. The framework generates compute kernels in the PTX assembler language which can be compiled to efficient GPU machine code by the NVIDIA JIT compiler. A comprehensive memory management was added to the framework so that applications, e.g. Chroma, can run unaltered on GPU clusters and supercomputers.

  7. New Design Methods and Algorithms for Multi-component Distillation Processes

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Methods and Algorithms for Multi-component Distillation Processes Improved Energy Efficiency through the Determination of Optimal Distillation Configuration The ability to apply low-energy distillation confgurations can allow chemical manufacturers to reduce energy consumption of both existing and grassroots plants. However, the determina- tion of an appropriate confguration is limited by an incomplete knowledge of the 'search space' for a proper distillation network. Currently, no systematic

  8. Final Technical Report - Stochastic Analysis of Advection-Diffusion-reaction Systems with Applications to Reactive Transport in Porous Media - DE-FG02-07ER24818

    SciTech Connect

    Karniadakis, George Em

    2014-03-11

    The main objective of this project is to develop new computational tools for uncertainty quantifica- tion (UQ) of systems governed by stochastic partial differential equations (SPDEs) with applications to advection-diffusion-reaction systems. We pursue two complementary approaches: (1) generalized polynomial chaos and its extensions and (2) a new theory on deriving PDF equations for systems subject to color noise. The focus of the current work is on high-dimensional systems involving tens or hundreds of uncertain parameters.

  9. Microsoft Word - Mitoneet.doc

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    October 2007 MitoNEET is a Uniquely Folded Outer Mitochondrial Membrane Protein Stabilized by Diabetes Drugs The rise in obesity in the United States parallels a dramatic increase in obesity-associated diseases, most notably type-2 diabetes. This disease is predicted to reach epidemic propor- tions in the next several decades (Zimmet et al 2001, Urek et al 2007). Thus, understand- ing the biochemical processes underlying type-2 diabetes and identifying new targets for therapeutic intervention

  10. Cross-Cutting Hydrogen Station Infrastructure Review Report

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    HYDROGEN STATION INFRASTRUCTURE REVIEW REPORT June 10th, 2016 U.S. Department of Energy Fuel Cell Technologies Office Annual Merit Review NOTICE This report was prepared as an account of work sponsored by an agency of the United States government. Neither the United States government nor any agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any informa- tion,

  11. Chapter 5: Lighting, HVAC, and Plumbing

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    5: Lighting, HVAC, and Plumbing High-Performance Engineering Design Lighting System Design Mechanical System Design Central Plant Systems Plumbing and Water Use Building Control Systems Electrical Power Systems Metering LANL | Chapter 5 High-Performance Engineering Design Lighting, HVAC, and Plumbing By now, the building envelope serves multiple roles. It protects the occupants from changing weather condi- tions and it plays a key part in meeting the occupants' comfort needs. The heating,

  12. American Recovery & Reinvestment Act Newsletter - Issue 16

    Office of Environmental Management (EM)

    The Savannah River Site (SRS) is committed to performing the Cold War-era cleanup safely and with transparency. Oversight and direc- tion provided by stakeholders is key to keeping American taxpayers informed of American Recovery and Reinvestment Act spending and progress as America works toward economic prosperity. SRS's $1.6 billion Recovery Act pack- age invests in the workforce and area businesses to complete important cleanup projects years ahead of origi- nal projections. "We are

  13. VTA, SamTrans Look into Future with Bus Demo

    Alternative Fuels and Advanced Vehicles Data Center

    induction motor for propulsion. Although there are several fuel cell chemistries and configura- tions, PEM is generally recog- nized as the best combination of electrochemistry, operating temperature, and weight for transportation applications. The fuel cell supplies electric current via an inverter to the propulsion motor, which is a proprietary design. This chassis- mounted, three-phase, induction motor is rated at 225 kW (369 horsepower). Hydrogen is stored onboard in eleven 5,000-psi

  14. NREL Assesses National Design Standards for Offshore Wind (Fact Sheet), NREL Highlights in Research & Development, NREL (National Renewable Energy Laboratory)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Report summarizes regulations, standards, and guidelines for the design and operation of offshore wind projects in the United States. In 2012, the American Wind Energy Association (AWEA) published its Offshore Compliance Recommended Practices that are based on existing standards (Inter- national Electrotechnical Commission, International Organization for Standardiza- tion, and American Petroleum Institute) and guidelines (American Bureau of Ship- ping and DNV GL). Although the AWEA document

  15. NREL's Cyanobacteria Engineering Shortens Biofuel Production Process, Captures CO2 (Fact Sheet), Highlights in Research & Development, NREL (National Renewable Energy Laboratory)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    The flexibility of cyanobacterial metabolism supports direct conversion of carbon dioxide (CO 2 ) to ethylene. Photosynthesis fuels growth in plants and algae, two of the primary components of biomass. Biomass, in turn, can be converted into various fuels and chemicals. NREL researchers have shortened this process by engineering one photosynthetic organism, cyanobacterium, so that it converts CO 2 directly into the target chemical ethylene, bypassing the biomass produc- tion and processing

  16. Summary and Comparison of BT16 with BT11

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    have substantial potential. Algae have a higher fuel yield per unit of biomass than terrestrial feedstocks. At higher farmgate prices, additional algal biomass could be available, but the prices will need to decrease for the full potential to be realized. Approach Biomass availability is dependent on many factors, including market, innova- tion, and time. As with BT2, terrestrial biomass supply increases with increasing price, higher yields, and over time. A major difference between BT2 and BT16

  17. Atmospheric Radiation Measurement Convective and Orographically Induced

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Convective and Orographically Induced Precipitation Study The U.S. Department of Energy's Atmospheric Radiation Measurement (ARM) Climate Research Facility is providing the ARM Mobile Facility (AMF) to support a long-term precipitation study in the Black Forest region of Germany. Requested by researchers from the University of Hohenheim, the AMF will be deployed as one of four heav- ily instrumented supersites established for the Convective and Orographically Induced Precipita- tion Study

  18. Reducing Power Factor Cost

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Low power factor is expensive and inefficient. Many utility companies charge you an additional fee if your power factor is less than 0.95. Low power factor also reduces your electrical system's distribu- tion capacity by increasing current flow and causing voltage drops. This fact sheet describes power factor and explains how you can improve your power factor to reduce electric bills and enhance your electrical system's capacity. REDUCING POWER FACTOR COST To understand power factor, visualize a

  19. Rock the Watt: An Energy Conservation Campaign at Pacific Northwest National Lab

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Rock the Watt was a direct applica- tion of the Framework for Organiza- tional Change that included building sustainability champions, integration of a sustainability checklist, and sup- port for employees to come up with their own energy saving actions. Rock the Watt: An Energy Conservation Campaign at Pacific Northwest National Lab Pacifc Northwest National Laboratory (PNNL), one of the seventeen Department of Energy laboratories, implemented the 3-month Rock the Watt campaign in FY2015 to

  20. SSL EVALUATION: OLED Lighting in the Offices of Aurora Lighting Design, Inc.

    Energy Saver

    EVALUATION: OLED Lighting in the Offices of Aurora Lighting Design, Inc. The first GATEWAY demonstra- tion involving OLEDs is also the first office test site for the use of OLEDs in general lighting. In March 2014, Aurora Lighting Design, Inc., in Grayslake, IL, made the bold decision to install an OLED lighting system during offce renovations. Aurora is a small architectural lighting design offce located in the lower level of a residence. With large windows overlook- ing a lake, the offce uses

  1. Industry | U.S. DOE Office of Science (SC)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    s more and more AFVs find their places in the transporta- tion industry, the need for qualified technicians to service these vehicles continues to grow. To help meet this need, transportation indus- try and education experts are working together to develop standards for AFV technician training, standards that will serve as a valuable tool for AFV technician training programs now and in the future. Background Section 411 of the Energy Policy Act of 1992 (EPAct) requires that the U.S. Department

  2. DOE/EIA-0202(89/2Q)

    Gasoline and Diesel Fuel Update

    2Q) 11989 SHORT-TERM t . t QUARTERLY PROJECTIONS ENERGY INFORMATION ADMINISTRATION This publication is available from the Superintendent of Documents, U.S. Government Printing Office (GPO). Informa tion about purchasing this or other Energy Information Administration (EIA) publications may be obtained from the GPO or the ElA's National Energy Information Center (NEIC). Questions on energy statistics should be directed to the NEIC by mail, telephone or telecommunications device for the deaf

  3. DOE/EIA-0202(89/4Q) SHOKT-TERM

    Gasoline and Diesel Fuel Update

    4Q) SHOKT-TERM t . t QUARTERLY PROJECTIONS This publication is available from the Superintendent of Documents, U.S. Government Printing Office (QPO). Informa tion about purchasing this or other Energy Information Administration (EIA) publications may be obtained from the GPO or the ElA's National Energy Information Center (NEIC). Questions on energy statistics should be directed to the NEIC by mail, telephone or telecommunications device for the deaf (TDD). Addresses, telephone numbers and hours

  4. Gina Pearson Assistant Administrator

    Gasoline and Diesel Fuel Update

    Gina Pearson Assistant Administrator for Communications Duties Gina Pearson is the Assistant Administrator (AA) for Communications, and in this capacity provides leadership and direction to conduct the U.S. Energy Information Administration's comprehensive communications program for diverse external customer groups and agency employees. The AA for Communications is responsible for Agency communications policies and standards, the www.eia.gov website, press and media rela- tions, marketing and

  5. HTS Cable Projects

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Superconductivity Partnerships with Industry ANL Air Liquide DOE Golden LANL AEP ORNL Nexans Niagara Mohawk Super Power American Superconductor NYSERDA BOC Praxair W ? tion systems. This is the most the nation. W superconductivity? HTS Cable Projects www.oe.energy.gov Phone: 202 \ 586-1411 Office of Electricity Delivery and Energy Reliability, OE-1 U.S. Department of Energy - 1000 Independence Avenue, SW - Washington, DC 20585. Plugging America Into the Future of Power "A National Effort to

  6. Creating orbiting vorticity vectors in magnetic particle suspensions through field symmetry transitions–a route to multi-axis mixing

    DOE PAGES [OSTI]

    Martin, James E.; Solis, Kyle Jameson

    2015-11-09

    It has recently been reported that two types of triaxial electric or magnetic fields can drive vorticity in dielectric or magnetic particle suspensions, respectively. The first type-symmetry -- breaking rational fields -- consists of three mutually orthogonal fields, two alternating and one dc, and the second type -- rational triads -- consists of three mutually orthogonal alternating fields. In each case it can be shown through experiment and theory that the fluid vorticity vector is parallel to one of the three field components. For any given set of field frequencies this axis is invariant, but the sign and magnitude ofmore » the vorticity (at constant field strength) can be controlled by the phase angles of the alternating components and, at least for some symmetry-breaking rational fields, the direction of the dc field. In short, the locus of possible vorticity vectors is a 1-d set that is symmetric about zero and is along a field direction. In this paper we show that continuous, 3-d control of the vorticity vector is possible by progressively transitioning the field symmetry by applying a dc bias along one of the principal axes. Such biased rational triads are a combination of symmetry-breaking rational fields and rational triads. A surprising aspect of these transitions is that the locus of possible vorticity vectors for any given field bias is extremely complex, encompassing all three spatial dimensions. As a result, the evolution of a vorticity vector as the dc bias is increased is complex, with large components occurring along unexpected directions. More remarkable are the elaborate vorticity vector orbits that occur when one or more of the field frequencies are detuned. As a result, these orbits provide the basis for highly effective mixing strategies wherein the vorticity axis periodically explores a range of orientations and magnitudes.« less

  7. Creating orbiting vorticity vectors in magnetic particle suspensions through field symmetry transitions–a route to multi-axis mixing

    SciTech Connect

    Martin, James E.; Solis, Kyle Jameson

    2015-11-09

    It has recently been reported that two types of triaxial electric or magnetic fields can drive vorticity in dielectric or magnetic particle suspensions, respectively. The first type-symmetry -- breaking rational fields -- consists of three mutually orthogonal fields, two alternating and one dc, and the second type -- rational triads -- consists of three mutually orthogonal alternating fields. In each case it can be shown through experiment and theory that the fluid vorticity vector is parallel to one of the three field components. For any given set of field frequencies this axis is invariant, but the sign and magnitude of the vorticity (at constant field strength) can be controlled by the phase angles of the alternating components and, at least for some symmetry-breaking rational fields, the direction of the dc field. In short, the locus of possible vorticity vectors is a 1-d set that is symmetric about zero and is along a field direction. In this paper we show that continuous, 3-d control of the vorticity vector is possible by progressively transitioning the field symmetry by applying a dc bias along one of the principal axes. Such biased rational triads are a combination of symmetry-breaking rational fields and rational triads. A surprising aspect of these transitions is that the locus of possible vorticity vectors for any given field bias is extremely complex, encompassing all three spatial dimensions. As a result, the evolution of a vorticity vector as the dc bias is increased is complex, with large components occurring along unexpected directions. More remarkable are the elaborate vorticity vector orbits that occur when one or more of the field frequencies are detuned. As a result, these orbits provide the basis for highly effective mixing strategies wherein the vorticity axis periodically explores a range of orientations and magnitudes.

  8. Plasma current resonance in asymmetric toroidal systems

    SciTech Connect

    Hazeltine, R. D.; Catto, Peter J.

    2015-09-15

    The well-known singularity in the magnetic differential equation for plasma current in an asymmetric toroidal confinement system is resolved by including in the pressure tensor corrections stemming from finite Larmor radius. The result provides an estimate of the amplitude of spikes in the parallel current that occur on rational magnetic surfaces. Resolution of the singularity is shown to depend on both the ambipolarity condition—the requirement of zero surface-averaged radial current—and the form of the magnetic differential equation near the rational surface.

  9. Subsiding land and falling ground water tables: public policy, private liability, and legal remedy

    SciTech Connect

    Bradley, M.D.; Carpenter, M.C.

    1986-07-01

    Focusing on the American Southwest, the authors review physical explanations of subsidence, then offer an explanation for the evolving doctrines of responsibility, laws of support, tort liability, and ground water management. Still in its infancy, the effort to develop effective measures to prevent subsidence or compensate for damages will become increasingly clear. They note the societal cost of not dealing directly and rationally with the problem and the subsequent loss of initiatives and options. Ground water withdrawal is a relatively new cause of land subsidence. Dealing with sub-surface support and the avoidance of subsidence damage is a geo-political problem calling for rational planning and management. 50 references.

  10. Agency's Work Having a Ripple Effect in Community | Department...

    Energy.gov [DOE] (indexed site)

    Reducing energy costs for families is a natural part of CAHRA's mission of fighting poverty in Pinal County. The agency is administering 2.1 million in Recovery Act funding to ...

  11. PACE Financing (Local Option- Contractual Assessments for Energy Efficient Improvements)

    Energy.gov [DOE]

    Keeping PACE in Texas is currently assisting counties and municipalities with the creation, design, and implementation of locally-administered PACE programs. It provides a "PACE in a Box" toolkit...

  12. NW Natural (Gas)- Commercial Energy Efficiency Rebate Program

    Office of Energy Efficiency and Renewable Energy (EERE)

    Energy Trust of Oregon administers energy efficiency rebate programs for both residential and commercial customers of NW Natural in Washington. To be eligible for the commercial gas rebate program,...

  13. Utility Scale Solar Incentive Program

    Energy.gov [DOE]

    HB 4037 of 2016 created the Solar Incentive Program for utility-scale solar development. The bill directs Oregon's Business Development Department (the Department) to establish and administer a...

  14. Methods for promoting wound healing and muscle regeneration with the cell signaling protein Nell1

    SciTech Connect

    Culiat, Cymbeline T

    2014-11-04

    The present invention provides methods for promoting wound healing and treating muscle atrophy in a mammal in need. The method comprises administering to the mammal a Nell1 protein or a Nell1 nucleic acid molecule.

  15. St. Lucie County- Solar and Energy Loan Fund (SELF)

    Energy.gov [DOE]

    St. Lucie County has partnered with local financial institutions and community leaders to establish the non-profit Solar and Energy Loan Fund (SELF), which administers a low-interest loan program. ...

  16. Made in Minnesota Solar Energy Production Incentive

    Energy.gov [DOE]

    Since January 2014, The Department of Commerce (DOC) has administered the Made in Minnesota Solar Energy Production Incentive pursuant to H.F. 729, which was enacted in May 2013. Systems must be ...

  17. MMPA- Residential Energy Efficiency Program

    Energy.gov [DOE]

    The following five Members separately administer individual programs: Anoka, Chaska, East Grand Forks, Elk River, and Shakopee. See the web site listed above and select your utility for more prog...

  18. Dollar and Energy Savings Loans

    Office of Energy Efficiency and Renewable Energy (EERE)

    The Nebraska Dollar and Energy Savings Loan program was created in 1990 using oil overcharge funds. The program, administered by the Nebraska Energy Office, makes available low-interest loans for...

  19. Local Option- Contractual Assessments for Energy Efficient Improvements

    Energy.gov [DOE]

    Keeping PACE in Texas is currently assisting counties and municipalities with the creation, design, and implementation of locally-administered PACE programs. It provides a "PACE in a Box" toolkit...

  20. NEW- DOE O 325.2, Position Management and Classification

    Directives, Delegations, and Other Requirements [Office of Management (MA)]

    The order establishes departmental requirements and responsibilities for classifying positions using general schedule (GS) and federal wage system (FWS) standards and for developing and administering a sound position management and classification program within the Department.