National Library of Energy BETA

Sample records for reporting interstitial therapy

  1. Syndrome of proximal interstitial deletion 4p15: Report of three cases and review of the literature

    SciTech Connect

    Chitayat, D.; Babul, R.; Teshima, I.E.

    1995-01-16

    We report on two boys and a girl with interstitial deletion in the short arm of chromosome 4 including the segment p15.2p15.33. All had normal growth with psychomotor retardation, multiple minor congenital anomalies, and a characteristic face distinct from that of the Wolf-Hirschhorn syndrome. One of the patients had congenitally enlarged penis. These patients resemble some of the previously reported patients with similar cytogenetic abnormalities and suggests the recognition of a specific clinical chromosome deletion syndrome. 12 refs., 6 figs., 1 tab.

  2. Interstitial duplication 19p

    SciTech Connect

    Stratton, R.F.; DuPont, B.R.; Moore, C.M.

    1995-07-17

    We report on a 9-month-old girl with an interstitial duplication of 19p, developmental delay, and multiple anomalies including bifrontal prominence, obtuse frontonasal angle, short columella, additional midline philtral pillar, midline ridge on the tongue, vertical midline ridge at the mental symphysis, and a complex congenital heart defect including severe branch pulmonary artery stenosis, secundum atrial septal defect (ASD), and several ventricular septal defects (VSDs). Use of fluorescent in situ hybridization (FISH) with chromosome 19- specific probes showed a direct duplication of bands 19p13.13 and 19p13.2. 6 refs., 1 fig.

  3. BERAC Subcommittee Report on Boron Neutron Capture Therapy (BNCT) Clinical

    Office of Science (SC)

    Trials. | U.S. DOE Office of Science (SC) BERAC Subcommittee Report on Boron Neutron Capture Therapy (BNCT) Clinical Trials. Biological and Environmental Research Advisory Committee (BERAC) BERAC Home Meetings Members Charges/Reports Current BERAC Charges Archive of BERAC Reports Charter .pdf file (135KB) BER Committees of Visitors Federal Advisory Committees BER Home Charges/Reports BERAC Subcommittee Report on Boron Neutron Capture Therapy (BNCT) Clinical Trials. Print Text Size: A A A

  4. Periodontium destruction associated with oncology therapy. Five case reports

    SciTech Connect

    Wright, W.E.

    1987-08-01

    Radiation treatment to the head and neck and cytotoxic chemotherapy can produce deleterious side effects to the periodontium that are generally transient in nature, reversible, and do not result in permanently visible defects. However, combinations of the malignant disease itself, the direct and indirect effects of medical therapy and associated oral infections, along with local trauma can lead to periodontal tissue destruction with resulting permanent architectural defects. Five case reports illustrate destructive alterations of the periodontium that were associated with oncology therapy. Proposed guidelines for periodontal treatment of compromised individuals undergoing oncology therapies are suggested.

  5. Ulcerative colitis and steroid-responsive, diffuse interstitial lung disease

    SciTech Connect

    Balestra, D.J.; Balestra, S.T.; Wasson, J.H.

    1988-07-01

    The authors describe a patient with ulcerative colitis and extracolonic manifestations in whom diffuse interstitial pulmonary disease developed that was responsive to glucocorticoid therapy one year after total proctocolectomy. The patient presented in December 1983 with a subacute course marked by cough and progressive exertional dyspnea, abnormal chest examination results, and a chest roentgenogram that revealed diffuse interstitital and alveolar infiltrates. A transbronchial biopsy specimen revealed a polymorphic interstitial infiltrate, mild interstitial fibrosis without apparent intraluminal fibrosis, and no vasculitis, granulomas, or significant eosinophilic infiltration. Within one week of the initiation of daily high-dose steroid therapy, the patient's symptoms dramatically improved; chest roentgenogram and forced vital capacity (60%) improved at a slower rate. All three measures deteriorated when alternate-day prednisone therapy was started but once again improved until the patient was totally asymptomatic, chest roentgenograms were normal, and forced vital capacity was 80% of the predicted value 2 1/2 years later.

  6. Computed Tomography–Guided Interstitial High-Dose-Rate Brachytherapy in Combination With Regional Positive Lymph Node Intensity-Modulated Radiation Therapy in Locally Advanced Peripheral Non–Small Cell Lung Cancer: A Phase 1 Clinical Trial

    SciTech Connect

    Xiang, Li; Zhang, Jian-wen; Lin, Sheng; Luo, Hui-Qun; Wen, Qing-Lian; He, Li-Jia; Shang, Chang-Ling; Ren, Pei-Rong; Yang, Hong-Ru; Pang, Hao-Wen; Yang, Bo; He, Huai-Lin; Chen, Yue; Wu, Jing-Bo

    2015-08-01

    Purpose: To assess the technical safety, adverse events, and efficacy of computed tomography (CT)-guided interstitial high-dose-rate (HDR) brachytherapy in combination with regional positive lymph node intensity modulated radiation therapy in patients with locally advanced peripheral non–small cell lung cancer (NSCLC). Methods and Materials: Twenty-six patients with histologically confirmed NSCLC were enrolled in a prospective, officially approved phase 1 trial. Primary tumors were treated with HDR brachytherapy. A single 30-Gy dose was delivered to the 90% isodose line of the gross lung tumor volume. A total dose of at least 70 Gy was administered to the 95% isodose line of the planning target volume of malignant lymph nodes using 6-MV X-rays. The patients received concurrent or sequential chemotherapy. We assessed treatment efficacy, adverse events, and radiation toxicity. Results: The median follow-up time was 28 months (range, 7-44 months). There were 3 cases of mild pneumothorax but no cases of hemothorax, dyspnea, or pyothorax after the procedure. Grade 3 or 4 acute hematologic toxicity was observed in 5 patients. During follow-up, mild fibrosis around the puncture point was observed on the CT scans of 2 patients, but both patients were asymptomatic. The overall response rates (complete and partial) for the primary mass and positive lymph nodes were 100% and 92.3%, respectively. The 1-year and 2-year overall survival (OS) rates were 90.9% and 67%, respectively, with a median OS of 22.5 months. Conclusion: Our findings suggest that HDR brachytherapy is safe and feasible for peripheral locally advanced NSCLC, justifying a phase 2 clinical trial.

  7. Objective and Longitudinal Assessment of Dermatitis After Postoperative Accelerated Partial Breast Irradiation Using High-Dose-Rate Interstitial Brachytherapy in Patients With Breast Cancer Treated With Breast Conserving Therapy: Reduction of Moisture Deterioration by APBI

    SciTech Connect

    Tanaka, Eiichi; Yamazaki, Hideya; Yoshida, Ken; Takenaka, Tadashi; Masuda, Norikazu; Kotsuma, Tadayuki; Yoshioka, Yasuo; Inoue, Takehiro

    2011-11-15

    Purpose: To objectively evaluate the radiation dermatitis caused by accelerated partial breast irradiation (APBI) using high-dose-rate interstitial brachytherapy. Patients and Methods: The skin color and moisture changes were examined using a newly installed spectrophotometer and corneometer in 22 patients who had undergone APBI using open cavity implant high-dose-rate interstitial brachytherapy (36 Gy in six fractions) and compared with the corresponding values for 44 patients in an external beam radiotherapy (EBRT) control group (50-60 Gy in 25-30 fractions within 5-6 weeks) after breast conserving surgery. Results: All values changed significantly as a result of APBI. The extent of elevation in a Asterisk-Operator (reddish) and reduction in L Asterisk-Operator (black) values caused by APBI were similar to those for EBRT, with slightly delayed recovery for 6-12 months after treatment owing to the surgical procedure. In contrast, only APBI caused a change in the b Asterisk-Operator values, and EBRT did not, demonstrating that the reduction in b Asterisk-Operator values (yellowish) depends largely on the surgical procedure. The changes in moisture were less severe after APBI than after EBRT, and the recovery was more rapid. The toxicity assessment using the Common Toxicity Criteria, version 3, showed that all dermatitis caused by APBI was Grade 2 or less. Conclusion: An objective analysis can quantify the effects of APBI procedures on color and moisture cosmesis. The radiation dermatitis caused by APBI using the present schedule showed an equivalent effect on skin color and a less severe effect on moisture than the effects caused by standard EBRT.

  8. DFT STUDY REVISES INTERSTITIAL CONFIGURATIONS IN HCP Zr

    SciTech Connect

    Samolyuk, German D; Golubov, Stanislav I; Osetskiy, Yury N; Stoller, Roger E

    2012-06-01

    Analysis of experimental result on microstructure evolution in irradiated Zr and alloys has demonstrated that available knowledge on self-interstitial defects in Zr is in contradiction. We therefore have initiated an extensive theoretical and modeling program to clarify this issue. In this report we present first ab initio calculations results of single SIA configurations in Zr. We demonstrate importance of simulations cell size, applied exchange-correlation functional and simulated c/a ratio. The results obtained demonstrate clearly that the most stable configurations are in basal plane and provide some evidences for enhanced interstitial transport along basal planes. The results obtained will be used in generation a new interatomic potential for Zr to be used in large-scale atomistic modeling of mechanisms relevant for radiation-induced microstructure evolution.

  9. Interstitial computing : utilizing spare cycles on supercomputers.

    SciTech Connect

    Clearwater, Scott Harvey; Kleban, Stephen David

    2003-06-01

    This paper presents an analysis of utilizing unused cycles on supercomputers through the use of many small jobs. What we call 'interstitial computing,' is important to supercomputer centers for both productivity and political reasons. Interstitial computing makes use of the fact that small jobs are more or less fungible consumers of compute cycles that are more efficient for bin packing than the typical jobs on a supercomputer. An important feature of interstitial computing is that it not have a significant impact on the makespan of native jobs on the machine. Also, a facility can obtain higher utilizations that may only be otherwise possible with more complicated schemes or with very long wait times. The key contribution of this paper is that it provides theoretical and empirical guidelines for users and administrators for how currently unused supercomputer cycles may be exploited. We find that that interstitial computing is a more effective means for increasing machine utilization than increasing native job run times or size.

  10. Systematic Review of Radiation Therapy Toxicity Reporting in Randomized Controlled Trials of Rectal Cancer: A Comparison of Patient-Reported Outcomes and Clinician Toxicity Reporting

    SciTech Connect

    Gilbert, Alexandra; Ziegler, Lucy; Martland, Maisie; Davidson, Susan; Efficace, Fabio; Sebag-Montefiore, David; Velikova, Galina

    2015-07-01

    The use of multimodal treatments for rectal cancer has improved cancer-related outcomes but makes monitoring toxicity challenging. Optimizing future radiation therapy regimens requires collection and publication of detailed toxicity data. This review evaluated the quality of toxicity information provided in randomized controlled trials (RCTs) of radiation therapy in rectal cancer and focused on the difference between clinician-reported and patient-reported toxicity. Medline, EMBASE, and the Cochrane Library were searched (January 1995-July 2013) for RCTs reporting late toxicity in patients treated with regimens including preoperative (chemo)radiation therapy. Data on toxicity measures and information on toxicity reported were extracted using Quantitative Analyses of Normal Tissue Effects in the Clinic recommendations. International Society for Quality of Life Research standards on patient-reported outcomes (PROs) were used to evaluate the quality of patient-reported toxicity. Twenty-one RCT publications met inclusion criteria out of 4144 articles screened. All PRO studies reported higher rates of toxicity symptoms than clinician-reported studies and reported on a wider range and milder symptoms. No clinician-reported study published data on sexual dysfunction. Of the clinician-reported studies, 55% grouped toxicity data related to an organ system together (eg “Bowel”), and 45% presented data only on more-severe (grade ≥3) toxicity. In comparison, all toxicity grades were reported in 79% of PRO publications, and all studies (100%) presented individual symptom toxicity data (eg bowel urgency). However, PRO reporting quality was variable. Only 43% of PRO studies presented baseline data, 28% did not use any psychometrically validated instruments, and only 29% of studies described statistical methods for managing missing data. Analysis of these trials highlights the lack of reporting standards for adverse events and reveals the differences between clinician and

  11. Bolus electron conformal therapy for the treatment of recurrent inflammatory breast cancer: a case report

    SciTech Connect

    Kim, Michelle M.; Kudchadker, Rajat J.; Kanke, James E.; Zhang, Sean; Perkins, George H.

    2012-07-01

    The treatment of locoregionally recurrent breast cancer in patients who have previously undergone radiation therapy is challenging. Special techniques are often required that both eradicate the disease and minimize the risks of retreatment. We report the case of a patient with an early-stage left breast cancer who developed inflammatory-type recurrence requiring re-irradiation of the chest wall using bolus electron conformal therapy with image-guided treatment delivery. The patient was a 51-year-old woman who had undergone lumpectomy, axillary lymph node dissection, and adjuvant whole-breast radiation therapy for a stage I left breast cancer in June 1998. In March 2009, she presented at our institution with biopsy-proven recurrent inflammatory carcinoma and was aggressively treated with multi-agent chemotherapy followed by mastectomy that left a positive surgical margin. Given the patient's prior irradiation and irregular chest wall anatomy, bolus electron conformal therapy was used to treat her chest wall and draining lymphatics while sparing the underlying soft tissue. The patient still had no evidence of disease 21 months after treatment. Our results indicate that bolus electron conformal therapy is an accessible, effective radiation treatment approach for recurrent breast cancer in patients with irregular chest wall anatomy as a result of surgery. This approach may complement standard techniques used to reduce locoregional recurrence in the postmastectomy setting.

  12. Di-interstitial defect in silicon revisited

    SciTech Connect

    Londos, C. A.; Antonaras, G.; Chroneos, A.; Department of Materials, Imperial College London, London SW7 2BP

    2013-11-21

    Infrared spectroscopy was used to study the defect spectrum of Cz-Si samples following fast neutron irradiation. We mainly focus on the band at 533 cm{sup ?1}, which disappears from the spectra at ?170 C, exhibiting similar thermal stability with the Si-P6 electron paramagnetic resonance (EPR) spectrum previously correlated with the di-interstitial defect. The suggested structural model of this defect comprises of two self-interstitial atoms located symmetrically around a lattice site Si atom. The band anneals out following a first-order kinetics with an activation energy of 0.88 0.3 eV. This value does not deviate considerably from previously quoted experimental and theoretical values for the di-interstitial defect. The present results indicate that the 533 cm{sup ?1} IR band originates from the same structure as that of the Si-P6 EPR spectrum.

  13. Impact of interstitial oxygen on the electronic and magnetic...

    Office of Scientific and Technical Information (OSTI)

    interstitial oxygen on the electronic and magnetic structure in superconducting Fe 1 + y Te O x thin films Citation Details In-Document Search Title: Impact of interstitial oxygen...

  14. Influence of interstitial Mn on magnetism in room-temperature ferromagnet Mn(1+delta)Sb

    SciTech Connect

    Taylor, Alice E; Berlijn, Tom; Hahn, Steven E; May, Andrew F; Williams, Travis J; Poudel, Lekhanath N; Calder, Stuart A; Fishman, Randy Scott; Stone, Matthew B; Aczel, Adam A; Cao, Huibo; Lumsden, Mark D; Christianson, Andrew D

    2015-01-01

    We report elastic and inelastic neutron scattering measurements of the high-TC ferromagnet Mn(1+delta)Sb. Measurements were performed on a large, TC = 434 K, single crystal with interstitial Mn content of delta=0.13. The neutron diffraction results reveal that the interstitial Mn has a magnetic moment, and that it is aligned antiparallel to the main Mn moment. We perform density functional theory calculations including the interstitial Mn, and find the interstitial to be magnetic in agreement with the diffraction data. The inelastic neutron scattering measurements reveal two features in the magnetic dynamics: i) a spin-wave-like dispersion emanating from ferromagnetic Bragg positions (H K 2n), and ii) a broad, non-dispersive signal centered at forbidden Bragg positions (H K 2n+1). The inelastic spectrum cannot be modeled by simple linear spin-wave theory calculations, and appears to be significantly altered by the presence of the interstitial Mn ions. The results show that the influence of the int

  15. Influence of interstitial Mn on magnetism in room-temperature ferromagnet Mn(1+delta)Sb

    DOE PAGES [OSTI]

    Taylor, Alice E; Berlijn, Tom; Hahn, Steven E; May, Andrew F; Williams, Travis J; Poudel, Lekhanath N; Calder, Stuart A; Fishman, Randy Scott; Stone, Matthew B; Aczel, Adam A; et al

    2015-01-01

    We report elastic and inelastic neutron scattering measurements of the high-TC ferromagnet Mn(1+delta)Sb. Measurements were performed on a large, TC = 434 K, single crystal with interstitial Mn content of delta=0.13. The neutron diffraction results reveal that the interstitial Mn has a magnetic moment, and that it is aligned antiparallel to the main Mn moment. We perform density functional theory calculations including the interstitial Mn, and find the interstitial to be magnetic in agreement with the diffraction data. The inelastic neutron scattering measurements reveal two features in the magnetic dynamics: i) a spin-wave-like dispersion emanating from ferromagnetic Bragg positions (Hmore » K 2n), and ii) a broad, non-dispersive signal centered at forbidden Bragg positions (H K 2n+1). The inelastic spectrum cannot be modeled by simple linear spin-wave theory calculations, and appears to be significantly altered by the presence of the interstitial Mn ions. The results show that the influence of the int« less

  16. Interstitial loop transformations in FeCr

    DOE PAGES [OSTI]

    Béland, Laurent Karim; Osetsky, Yuri N.; Stoller, Roger E.; Xu, Haixuan

    2015-03-27

    Here, we improve the Self-Evolving Atomistic Kinetic Monte Carlo (SEAKMC) algorithm by integrating the Activation Relaxation Technique nouveau (ARTn), a powerful open-ended saddle-point search method, into the algorithm. We use it to investigate the reaction of 37-interstitial 1/2[1 1 1] and 1/2[View the MathML source] loops in FeCr at 10 at.% Cr. They transform into 1/2[1 1 1], 1/2[View the MathML source], [1 0 0] and [0 1 0] 74-interstitial clusters with an overall barrier of 0.85 eV. We find that Cr decoration locally inhibits the rotation of crowdions, which dictates the final loop orientation. Moreover, the final loop orientationmore » depends on the details of the Cr decoration. Generally, a region of a given orientation is favored if Cr near its interface with a region of another orientation is able to inhibit reorientation at this interface more than the Cr present at the other interfaces. Also, we find that substitutional Cr atoms can diffuse from energetically unfavorable to energetically favorable sites within the interlocked 37-interstitial loops conformation with barriers of less than 0.35 eV.« less

  17. Bistability of Cation Interstitials in II-VI Semiconductors

    SciTech Connect

    Wei, S. H.; Dalpian, G. M.

    2005-11-01

    The stability of cation interstitials in II-VI semiconductors is studied using ab initio methods. We find that interstitials in the neutral charge state are more stable in the tetrahedral interstitial site near the cation, whereas in the (2+) charge state, they are more stable near the anion. The diffusion energy barrier changes when the defect charge state changes. Therefore, if electrons/holes are taken from the defect level by light, changing its charge state, the interstitial atom will be able to diffuse almost spontaneously due to a reduced diffusion barrier.

  18. Syndrome of proximal interstitial deletion 4p15

    SciTech Connect

    Fryns, J.P.

    1995-09-11

    In this journal, Chitayat et al. reported on 2 boys and a girl with interstitial deletion in the short arm of chromosome 4, including p15.2p15.33. All 3 patients had a characteristic face distinct from that of Wolf-Hirschhorn syndrome and multiple minor congenital anomalies. One patient had a congenitally enlarged penis. The authors noted that all had normal growth, and all had moderate psychomotor retardation (patient 1, developmental age of 4-6 years at age 9 years; patient 2, mental age 6 years at age 25 years; and patient 3, global delay with hypotonia, difficulties in both gross and fine motor development, and persistent delay in language skills). 5 refs., 1 fig.

  19. Self-Reported Cognitive Outcomes in Patients With Brain Metastases Before and After Radiation Therapy

    SciTech Connect

    Cole, Ansa Maer; Scherwath, Angela; Ernst, Gundula; Lanfermann, Heinrich; Bremer, Michael; Steinmann, Diana

    2013-11-15

    Purpose: Patients with brain metastases may experience treatment-related cognitive deficits. In this study, we prospectively assessed the self-reported cognitive abilities of patients with brain metastases from any solid primary cancer before and after irradiation of the brain. Methods and Materials: The treatment group (TG) consisted of adult patients (n=50) with brain metastases who received whole or partial irradiation of the brain without having received prior radiation therapy (RT). The control group (CG) consisted of breast cancer patients (n=27) without cranial involvement who were treated with adjuvant RT. Patients were recruited between May 2008 and December 2010. Self-reported cognitive abilities were acquired before RT and 6 weeks, 3 months, and 6 months after irradiation. The information regarding the neurocognitive status was collected by use of the German questionnaires for self-perceived deficits in attention (FEDA) and subjectively experienced everyday memory performance (FEAG). Results: The baseline data showed a high proportion of self-perceived neurocognitive deficits in both groups. A comparison between the TG and the CG regarding the course of self-reported outcomes after RT showed significant between-group differences for the FEDA scales 2 and 3: fatigue and retardation of daily living activities (P=.002) and decrease in motivation (P=.032) with an increase of attention deficits in the TG, but not in the CG. There was a trend towards significance in FEDA scale 1: distractibility and retardation of mental processes (P=.059) between the TG and the CG. The FEAG assessment presented no significant differences. An additional subgroup analysis within the TG was carried out. FEDA scale 3 showed significant differences in the time-related progress between patients with whole-brain RT and those receiving hypofractionated stereotactic RT (P=.025), with less decrease in motivation in the latter group. Conclusion: Self-reported attention declined in

  20. Interstitial rotating shield brachytherapy for prostate cancer

    SciTech Connect

    Adams, Quentin E. Xu, Jinghzu; Breitbach, Elizabeth K.; Li, Xing; Rockey, William R.; Kim, Yusung; Wu, Xiaodong; Flynn, Ryan T.; Enger, Shirin A.

    2014-05-15

    Purpose: To present a novel needle, catheter, and radiation source system for interstitial rotating shield brachytherapy (I-RSBT) of the prostate. I-RSBT is a promising technique for reducing urethra, rectum, and bladder dose relative to conventional interstitial high-dose-rate brachytherapy (HDR-BT). Methods: A wire-mounted 62 GBq{sup 153}Gd source is proposed with an encapsulated diameter of 0.59 mm, active diameter of 0.44 mm, and active length of 10 mm. A concept model I-RSBT needle/catheter pair was constructed using concentric 50 and 75 μm thick nickel-titanium alloy (nitinol) tubes. The needle is 16-gauge (1.651 mm) in outer diameter and the catheter contains a 535 μm thick platinum shield. I-RSBT and conventional HDR-BT treatment plans for a prostate cancer patient were generated based on Monte Carlo dose calculations. In order to minimize urethral dose, urethral dose gradient volumes within 0–5 mm of the urethra surface were allowed to receive doses less than the prescribed dose of 100%. Results: The platinum shield reduced the dose rate on the shielded side of the source at 1 cm off-axis to 6.4% of the dose rate on the unshielded side. For the case considered, for the same minimum dose to the hottest 98% of the clinical target volume (D{sub 98%}), I-RSBT reduced urethral D{sub 0.1cc} below that of conventional HDR-BT by 29%, 33%, 38%, and 44% for urethral dose gradient volumes within 0, 1, 3, and 5 mm of the urethra surface, respectively. Percentages are expressed relative to the prescription dose of 100%. For the case considered, for the same urethral dose gradient volumes, rectum D{sub 1cc} was reduced by 7%, 6%, 6%, and 6%, respectively, and bladder D{sub 1cc} was reduced by 4%, 5%, 5%, and 6%, respectively. Treatment time to deliver 20 Gy with I-RSBT was 154 min with ten 62 GBq {sup 153}Gd sources. Conclusions: For the case considered, the proposed{sup 153}Gd-based I-RSBT system has the potential to lower the urethral dose relative to HDR-BT by 29

  1. Complexes of self-interstitials with oxygen atoms in Ge

    SciTech Connect

    Khirunenko, L. I.; Pomozov, Yu. V.; Sosnin, M. G.; Abrosimov, N. V.; Riemann, H.

    2014-02-21

    Interactions of germanium self-interstitials with interstitial oxygen atoms in Ge subjected to irradiation at ?80 K and subsequently to annealing have been studied. To distinguish the processes involving vacancies and self-interstitials the doping with tin was used. It was shown that absorption lines with maximum at 602, 674, 713 and 803 cm{sup ?1} are self-interstitials-related. Two lines at 602 and 674, which develop upon annealing in the temperature range 180240 K, belong to IO complexes, while the bands at 713 and 803 cm{sup ?1}, which emerge after annealing at T>220 K, are associated with I{sub 2}O. It is argued that the annealing of IO occurs by two mechanisms: by dissociation and by diffusion.

  2. Hydrogen passivation of interstitial iron in boron-doped multicrystalline silicon during annealing

    SciTech Connect

    Liu, AnYao; Sun, Chang; Macdonald, Daniel

    2014-11-21

    Effective hydrogenation of interstitial iron in boron-doped multicrystalline silicon wafers is reported. The multicrystalline silicon wafers were annealed with plasma-enhanced chemical vapour deposited silicon nitride films, at temperatures of 400?C??900?C and for times from minutes to hours. At low temperatures where a combined effect of hydrogenation and precipitation of dissolved Fe is expected, results show that the hydrogenation process dominates the effect of precipitation. The concentrations of dissolved interstitial iron reduce by more than 90% after a 30-min anneal at temperatures between 600 and 900?C. The most effective reduction occurs at 700?C, where 99% of the initial dissolved iron is hydrogenated after 30?min. The results show that the observed reductions in interstitial Fe concentrations are not caused by the internal gettering of Fe at structural defects or by an enhanced diffusivity of Fe due to the presence of hydrogen. The hydrogenation process is conjectured to be the pairing of positively charged iron with negatively charged hydrogen, forming less recombination active Fe-H complexes in silicon.

  3. Interstitial carbon formation in irradiated copper-doped silicon

    SciTech Connect

    Yarykin, N. A.; Weber, J.

    2015-06-15

    The influence of a copper impurity on the spectrum of defects induced in p-Si crystals containing a low oxygen concentration by irradiation with electrons with an energy of 5 MeV at room temperature is studied by deep-level transient spectroscopy. It is found that interstitial carbon atoms (C{sub i}) which are the dominant defects in irradiated samples free of copper are unobservable immediately after irradiation, if the concentration of mobile interstitial copper atoms (Cu{sub i}) is higher than the concentration of radiation defects. This phenomenon is attributed to the formation of (Cu{sub i}, C{sub i}) complexes, which do not introduce levels into the lower half of the band gap. It is shown that these complexes dissociate upon annealing at temperatures of 300–340 K and, thus, bring about the appearance of interstitial carbon.

  4. Friedel-Like Oscillations from Interstitial Iron in Superconducting...

    Office of Scientific and Technical Information (OSTI)

    Fe1+yTe0.62Se0.38 Citation Details In-Document Search Title: Friedel-Like Oscillations from Interstitial Iron in Superconducting Fe1+yTe0.62Se0.38 Using polarized and ...

  5. Lymphocytic interstitial pneumonitis: a cause of pulmonary gallium-67 uptake in a child with acquired immunodeficiency syndrome

    SciTech Connect

    Zuckier, L.S.; Ongseng, F.; Goldfarb, C.R.

    1988-05-01

    Lymphocytic interstitial pneumonitis (LIP) is currently recognized as a frequent pediatric manifestation of the acquired immunodeficiency syndrome (AIDS). We report the gallium scan findings in a 3-yr-old girl with this disorder and review its clinical, radiologic, and pathologic features. LIP must be a prime consideration in the differential diagnosis of diffuse pulmonary gallium uptake in pediatric AIDS patients. Further experience will afford greater perspective on the diagnostic role that nuclear medicine will ultimately play in this disease. 49 references.

  6. Final Report for the “WSU Neutron Capture Therapy Facility Support”

    SciTech Connect

    Gerald E. Tripard; Keith G. Fox

    2006-08-24

    The objective for the cooperative research program for which this report has been written was to provide separate NCT facility user support for the students, faculty and scientists who would be doing the U.S. Department of Energy Office (DOE) of Science supported advanced radiotargeted research at the WSU 1 megawatt TRIGA reactor. The participants were the Idaho National laboratory (INL, P.I., Dave Nigg), the Veterinary Medical Research Center of Washington State University (WSU, Janean Fidel and Patrick Gavin), and the Washington State University Nuclear Radiation Center (WSU, P.I., Gerald Tripard). A significant number of DOE supported modifications were made to the WSU reactor in order to create an epithermal neutron beam while at the same time maintaining the other activities of the 1 MW reactor. These modifications were: (1) Removal of the old thermal column. (2) Construction and insertion of a new epithermal filter, collimator and shield. (3) Construction of a shielded room that could accommodate the very high radiation field created by an intense neutron beam. (4) Removal of the previous reactor core fuel cluster arrangement. (5) Design and loading of the new reactor core fuel cluster arrangement in order to optimize the neutron flux entering the epithermal neutron filter. (6) The integration of the shielded rooms interlocks and radiological controls into the SCRAM chain and operating electronics of the reactor. (7) Construction of a motorized mechanism for moving and remotely controlling the position of the entire reactor bridge. (8) The integration of the reactor bridge control electronics into the SCRAM chain and operating electronics of the reactor. (9) The design, construction and attachment to the support structure of the reactor of an irradiation box that could be inserted into position next to the face of the reactor. (Necessitated by the previously mentioned core rearrangement). All of the above modifications were successfully completed and tested

  7. Surprising stability of neutral interstitial hydrogen in diamond and cubic BN

    DOE PAGES [OSTI]

    Lyons, J. L.; Van de Walle, C. G.

    2016-01-21

    We report that in virtually all semiconductors and insulators, hydrogen interstitials (Hi) act as negative-U centers, implying that hydrogen is never stable in the neutral charge state. Using hybrid density functional calculations, we find a different behavior for Hi in diamond and cubic BN. In diamond, Hi is a very strong positive-U center, and the H0icharge state is stable over a Fermi-level range of more than 2 eV. In cubic BN, a III-V compound similar to diamond, we also find positive-U behavior, though over a much smaller Fermi-level range. Finally, these results highlight the unique behavior of Hi in thesemore » covalent wide-band-gap semiconductors.« less

  8. Interstitially stabilized phases in the zirconium-nickel system

    SciTech Connect

    MacKay, R.A.

    1993-07-01

    Addition of nonmetal interstitial atoms to Zr-Ni compounds has resulted in several new phases. A single-crystal x-ray study was carried out for Zr{sub 3}NiO. Zr{sub 4}Ni{sub 2}O is a high- temperature phase, forming in samples annealed at 1250 C. Huekel band calculations led to prediction and confirmation of additional phases in more electron rich systems. Other phases studied by XRD are Zr{sub 6}Ni{sub 4}Ti{sub 2}O{sub 0.6}, Nb{sub 6}Ni{sub 6}O, and Nb{sub 6}Ni{sub 4}Ta{sub 2}O{sub 2}. Phases identified by powder diffraction are Nb{sub 4}Ni{sub 2}O, Zr{sub 4}Cu{sub 2}O, and Zr{sub 6}Co{sub 4}Ti{sub 2}O. New Zr kappa phases in space group P6s{sub 3}/mmc were found: Zr{sub 9}Mo{sub 4}SO{sub x} and Zr{sub 9}W{sub 4}(S,Ni)O{sub 3}. A new structure type was discovered with Zr{sub 6}Ni{sub 6}TiSiO{sub 1.8}. In all these interstitially stabilized phases, O is coordinated in Zr octahedral; there are no Ni-O interactions.

  9. Outcomes of High-Dose-Rate Interstitial Brachytherapy in the Treatment of Locally Advanced Cervical Cancer: Long-term Results

    SciTech Connect

    Pinn-Bingham, Melva; Puthawala, Ajmel A.; Syed, A.M. Nisar; Sharma, Anil; DiSaia, Philip; Berman, Michael; Tewari, Krishnansu S.; Randall-Whitis, Leslie; Mahmood, Usama; Ramsinghani, Nilam; Kuo, Jeffrey; Chen, Wen-Pin; McLaren, Christine E.

    2013-03-01

    Purpose: The purpose of this study was to determine locoregional control (LRC), disease-free survival (DFS), and toxicity of high-dose-rate interstitial brachytherapy (HDR-ISBT) in the treatment of locally advanced cervical cancer. Methods and Materials: Between March 1996 and May 2009, 116 patients with cervical cancer were treated. Of these, 106 (91%) patients had advanced disease (International Federation of Gynecology and Obstetrics stage IIB-IVA). Ten patients had stage IB, 48 had stage II, 51 had stage III, and 7 had stage IVA disease. All patients were treated with a combination of external beam radiation therapy (EBRT) to the pelvis (5040 cGy) and 2 applications of HDR-ISBT to a dose of 3600 cGy to the implanted volume. Sixty-one percent of patients also received interstitial hyperthermia, and 94 (81%) patients received chemotherapy. Results: Clinical LRC was achieved in 99 (85.3%) patients. Three-year DFS rates were 59%, 67%, 71%, and 57% for patients with stage IB, II, III, and IVA disease, respectively. The 5-year DFS and overall survival rates for the entire group were 60% and 44%, respectively. Acute and late toxicities were within acceptable limits. Conclusions: Locally advanced cervical cancer patients for whom intracavitary BT is unsuitable can achieve excellent LRC and OS with a combination of EBRT and HDR-ISBT.

  10. Measurements of the oxidation state and concentration of plutonium in interstitial waters of the Irish Sea

    SciTech Connect

    Nelson, D.M.; Lovett, M.B.

    1980-01-01

    The question of plutonium movement in interstitial waters resulting from diffusion along concentration gradients or from advective flow is addressed. The results of measurements of both the concentration and the oxidation state of plutonium in interstitial water collected from sediments near the Windscale discharge, in the solid phases of these sediments and in seawater and suspended solids collected at the coring locations are discussed. (ACR)

  11. Intensity-Modulated Radiotherapy as Primary Therapy for Prostate Cancer: Report on Acute Toxicity After Dose Escalation With Simultaneous Integrated Boost to Intraprostatic Lesion

    SciTech Connect

    Fonteyne, Valerie Villeirs, Geert; Speleers, Bruno; Neve, Wilfried de; Wagter, Carlos de; Lumen, Nicolas; Meerleer, Gert de

    2008-11-01

    Purpose: To report on the acute toxicity of a third escalation level using intensity-modulated radiotherapy for prostate cancer (PCa) and the acute toxicity resulting from delivery of a simultaneous integrated boost (SIB) to an intraprostatic lesion (IPL) detected on magnetic resonance imaging (MRI), with or without spectroscopy. Methods and Materials: Between January 2002 and March 2007, we treated 230 patients with intensity-modulated radiotherapy to a third escalation level as primary therapy for prostate cancer. If an IPL (defined by MRI or MRI plus spectroscopy) was present, a SIB was delivered to the IPL. To report on acute toxicity, patients were seen weekly during treatment and 1 and 3 months after treatment. Toxicity was scored using the Radiation Therapy Oncology Group toxicity scale, supplemented by an in-house-developed scoring system. Results: The median dose to the planning target volume was 78 Gy. An IPL was found in 118 patients. The median dose to the MRI-detected IPL and MRI plus spectroscopy-detected IPL was 81 Gy and 82 Gy, respectively. No Grade 3 or 4 acute gastrointestinal toxicity developed. Grade 2 acute gastrointestinal toxicity was present in 26 patients (11%). Grade 3 genitourinary toxicity was present in 15 patients (7%), and 95 patients developed Grade 2 acute genitourinary toxicity (41%). No statistically significant increase was found in Grade 2-3 acute gastrointestinal or genitourinary toxicity after a SIB to an IPL. Conclusion: The results of our study have shown that treatment-induced acute toxicity remains low when intensity-modulated radiotherapy to 80 Gy as primary therapy for prostate cancer is used. In addition, a SIB to an IPL did not increase the severity or incidence of acute toxicity.

  12. Photodynamic Therapy of the Canine Prostate: Intra-arterial Drug Delivery

    SciTech Connect

    Moore, Ronald B. Xiao, Zhengwen; Owen, Richard J.; Ashforth, Robert; Dickey, Dwayne; Helps, Cathy; Tulip, John

    2008-01-15

    Purpose. Interstitial photodynamic therapy (PDT) selectively destroys tissue targeted with a photosensitizer and then exposed to light of a specific wavelength. We report a novel delivery method-intra-arterial drug delivery for PDT of the prostate-in a canine model.Methods. To evaluate drug distribution, the prostatovesical artery was selectively cannulated and photosensitizers alone or in conjunction with 99m-technetium-labeled macro-aggregated albumin ({sup 99m}Tc-MAA) were injected via a 3 Fr microcatheter in 8 animals. One dog was followed for 3 months to determine tolerance and toxicity. The remaining animals were euthanized and imaged with whole-body single photon emission CT and gamma counting for radioactivity distribution. Photosensitizer distribution was further analyzed by fluorescence confocal microscopy and tissue chemical extraction. To evaluate PDT, the photosensitizer QLT0074 was infused in 3 animals followed by interstitial illumination with 690 nm laser light. Results. Intra-arterial infusion selectively delivered drugs to the prostate, with both radioactivity and photosensitizer levels significantly higher (up to 18 times) than in the surrounding organs (i.e., rectum). With unilateral injection of {sup 99m}Tc-MAA, only the injected half of the prostate showed activity whereas bilateral administration resulted in drug delivery to the entire prostate. PDT resulted in comprehensive damage to the prostate without severe complications or systemic toxicity. Conclusion. Injection of radiolabeled MAA into the prostatovesical artery results in distribution within the prostate with negligible amounts reaching the adjacent organs. PDT also demonstrates selective damage to the prostate, which warrants clinical application in targeted prostate therapies.

  13. Is Stereotactic Body Radiation Therapy an Attractive Option for Unresectable Liver Metastases? A Preliminary Report From a Phase 2 Trial

    SciTech Connect

    Scorsetti, Marta; Arcangeli, Stefano; Tozzi, Angelo; Comito, Tiziana; Alongi, Filippo; Navarria, Pierina; Mancosu, Pietro; Reggiori, Giacomo; Fogliata, Antonella; Torzilli, Guido; Tomatis, Stefano; Cozzi, Luca

    2013-06-01

    Purpose: To evaluate the feasibility of high-dose stereotactic body radiation therapy (SBRT) in the treatment of unresectable liver metastases. Methods and Materials: Patients with 1 to 3 liver metastases, with maximum individual tumor diameters less than 6 cm and a Karnofsky Performance Status of at least 70, were enrolled and treated by SBRT on a phase 2 clinical trial. Dose prescription was 75 Gy on 3 consecutive days. SBRT was delivered using the volumetric modulated arc therapy by RapidArc (Varian, Palo Alto, CA) technique. The primary end-point was in-field local control. Secondary end-points were toxicity and survival. Results: Between February 2010 and September 2011, a total of 61 patients with 76 lesions were treated. Among the patients, 21 (34.3%) had stable extrahepatic disease at study entry. The most frequent primary sites were colorectal (45.9%) and breast (18%). Of the patients, 78.7% had 1 lesion, 18.0% had 2 lesions, and 3.3% had 3 lesions. After a median of 12 months (range, 2-26 months), the in-field local response rate was 94%. The median overall survival rate was 19 months, and actuarial survival at 12 months was 83.5%. None of the patients experienced grade 3 or higher acute toxicity. No radiation-induced liver disease was detected. One patient experienced G3 late toxicity at 6 months, resulting from chest wall pain. Conclusions: SBRT for unresectable liver metastases can be considered an effective, safe, and noninvasive therapeutic option, with excellent rates of local control and a low treatment-related toxicity.

  14. Muddy Water? Variation in Reporting Receipt of Breast Cancer Radiation Therapy by Population-Based Tumor Registries

    SciTech Connect

    Walker, Gary V.; Giordano, Sharon H.; Williams, Melanie; Jiang, Jing; Niu, Jiangong; MacKinnon, Jill; Anderson, Patricia; Wohler, Brad; Sinclair, Amber H.; Boscoe, Francis P.; Schymura, Maria J.; Buchholz, Thomas A.; Smith, Benjamin D.

    2013-07-15

    Purpose: To evaluate, in the setting of breast cancer, the accuracy of registry radiation therapy (RT) coding compared with the gold standard of Medicare claims. Methods and Materials: Using Surveillance, Epidemiology, and End Results (SEER)–Medicare data, we identified 73,077 patients aged ≥66 years diagnosed with breast cancer in the period 2001-2007. Underascertainment (1 - sensitivity), sensitivity, specificity, κ, and χ{sup 2} were calculated for RT receipt determined by registry data versus claims. Multivariate logistic regression characterized patient, treatment, and geographic factors associated with underascertainment of RT. Findings in the SEER–Medicare registries were compared with three non-SEER registries (Florida, New York, and Texas). Results: In the SEER–Medicare registries, 41.6% (n=30,386) of patients received RT according to registry coding, versus 49.3% (n=36,047) according to Medicare claims (P<.001). Underascertainment of RT was more likely if patients resided in a newer SEER registry (odds ratio [OR] 1.70, 95% confidence interval [CI] 1.60-1.80; P<.001), rural county (OR 1.34, 95% CI 1.21-1.48; P<.001), or if RT was delayed (OR 1.006/day, 95% CI 1.006-1.007; P<.001). Underascertainment of RT receipt in SEER registries was 18.7% (95% CI 18.6-18.8%), compared with 44.3% (95% CI 44.0-44.5%) in non-SEER registries. Conclusions: Population-based tumor registries are highly variable in ascertainment of RT receipt and should be augmented with other data sources when evaluating quality of breast cancer care. Future work should identify opportunities for the radiation oncology community to partner with registries to improve accuracy of treatment data.

  15. Quality assurance for image-guided radiation therapy utilizing CT-based technologies: A report of the AAPM TG-179

    SciTech Connect

    Bissonnette, Jean-Pierre; Balter, Peter A.; Dong Lei; Langen, Katja M.; Lovelock, D. Michael; Miften, Moyed; Moseley, Douglas J.; Pouliot, Jean; Sonke, Jan-Jakob; Yoo, Sua

    2012-04-15

    Purpose: Commercial CT-based image-guided radiotherapy (IGRT) systems allow widespread management of geometric variations in patient setup and internal organ motion. This document provides consensus recommendations for quality assurance protocols that ensure patient safety and patient treatment fidelity for such systems. Methods: The AAPM TG-179 reviews clinical implementation and quality assurance aspects for commercially available CT-based IGRT, each with their unique capabilities and underlying physics. The systems described are kilovolt and megavolt cone-beam CT, fan-beam MVCT, and CT-on-rails. A summary of the literature describing current clinical usage is also provided. Results: This report proposes a generic quality assurance program for CT-based IGRT systems in an effort to provide a vendor-independent program for clinical users. Published data from long-term, repeated quality control tests form the basis of the proposed test frequencies and tolerances.Conclusion: A program for quality control of CT-based image-guidance systems has been produced, with focus on geometry, image quality, image dose, system operation, and safety. Agreement and clarification with respect to reports from the AAPM TG-101, TG-104, TG-142, and TG-148 has been addressed.

  16. SU-E-J-04: Integration of Interstitial High Intensity Therapeutic Ultrasound Applicators On a Clinical MRI-Guided High Intensity Focused Ultrasound Treatment Planning Software Platform

    SciTech Connect

    Ellens, N; Partanen, A; Ghoshal, G; Burdette, E; Farahani, K

    2015-06-15

    Purpose: Interstitial high intensity therapeutic ultrasound (HITU) applicators can be used to ablate tissue percutaneously, allowing for minimally-invasive treatment without ionizing radiation [1,2]. The purpose of this study was to evaluate the feasibility and usability of combining multielement interstitial HITU applicators with a clinical magnetic resonance imaging (MRI)-guided focused ultrasound software platform. Methods: The Sonalleve software platform (Philips Healthcare, Vantaa, Finland) combines anatomical MRI for target selection and multi-planar MRI thermometry to provide real-time temperature information. The MRI-compatible interstitial US applicators (Acoustic MedSystems, Savoy, IL, USA) had 1–4 cylindrical US elements, each 1 cm long with either 180° or 360° of active surface. Each applicator (4 Fr diameter, enclosed within a 13 Fr flexible catheter) was inserted into a tissue-mimicking agar-silica phantom. Degassed water was circulated around the transducers for cooling and coupling. Based on the location of the applicator, a virtual transducer overlay was added to the software to assist targeting and to allow automatic thermometry slice placement. The phantom was sonicated at 7 MHz for 5 minutes with 6–8 W of acoustic power for each element. MR thermometry data were collected during and after sonication. Results: Preliminary testing indicated that the applicator location could be identified in the planning images and the transducer locations predicted within 1 mm accuracy using the overlay. Ablation zones (thermal dose ≥ 240 CEM43) for 2 active, adjacent US elements ranged from 18 mm × 24 mm (width × length) to 25 mm × 25 mm for the 6 W and 8 W sonications, respectively. Conclusion: The combination of interstitial HITU applicators and this software platform holds promise for novel approaches in minimally-invasive MRI-guided therapy, especially when bony structures or air-filled cavities may preclude extracorporeal HIFU.[1] Diederich et al

  17. Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Reports Reports Individual Permit reports are prepared annually to facilitate public review of activities for the previous year. Contact Environmental Communication & Public Involvement P.O. Box 1663 MS M996 Los Alamos, NM 87545 (505) 667-0216 Email Individual Permit for Storm Water Reports Annual Report 2015 (pdf) 2014 (pdf) 2013 (pdf) Submittal Letter (pdf) 2012 (pdf) Submittal Letter (pdf) 2011 (pdf) Background Metals and Radioactivity Report Background Metals Concentrations and

  18. Migration mechanisms of oxygen interstitial cluste (Journal Article...

    Office of Scientific and Technical Information (OSTI)

    Report Number(s): INLJOU-13-29349 DOE Contract Number: DE-AC07-05ID14517 Resource Type: Journal Article Resource Relation: Journal Name: Journal of Physics: Condensed Matter; ...

  19. Migration Mechanisms of Oxygen Interstitial Clusters in UO2 ...

    Office of Scientific and Technical Information (OSTI)

    Authors: Xian-Ming Bai ; Anter El-Azab ; Jianguo Yu ; Todd R. Allen Publication Date: 2013-01-01 OSTI Identifier: 1057705 Report Number(s): INLJOU-12-27046 DOE Contract Number: ...

  20. Ultra-low contact resistance at an epitaxial metal/oxide heterojunction through interstitial site doping

    SciTech Connect

    Chambers, Scott A.; Gu, Meng; Sushko, Petr V.; Yang, Hao; Wang, Chong M.; Browning, Nigel D.

    2013-08-07

    The ability to form reliable, low-resistance Ohmic contacts is of critical importance to the ongoing development of oxide electronics. Most metals form Schottky barriers when deposited on oxide surfaces. Ohmic contacts rarely occur, and the associated contact resistances are not particularly low. Little is known at an atomistic level about what leads to a good Ohmic contact on a wide-gap oxide. Here we describe the structure of a simple, yet exceptionally low-contact resistance Ohmic metal on an important oxide semiconductor -- epitaxial Cr on Nb-doped SrTiO3(001). Heteroepitaxial growth is accompanied by Cr diffusion into the STO and occupation of interstitial sites within the first few atomic planes. Interstitial Cr is ionized and the resulting electrons occupy the STO conduction band, resulting in effective metallization near the interface.

  1. Chemical composition of interstitial waters from the Japan Sea, ODP Leg 128

    SciTech Connect

    Sturz, A. ); Von Breymann, M.; Dunbar, R. )

    1990-06-01

    During ODP Leg 128, interstitial waters were recovered from Oki Ridge (Site 798) and Kita-Yamato Trough (Site 799) sediment, Sea of Japan. Interstitial water chemical composition reflects diagenetic processes. Evidence indicating organic matter degradation processes includes sulfate depletion, high ammonium concentrations, and shallow maxima of dissolved phosphate. Rapid alkalinity increases in the uppermost sections of the sediments are accompanied by decreases in dissolved calcium, reflecting inorganic calcite precipitation. Authigenic dolomitization results in changes in slopes of the Mg/Ca molar ratios with depth. The opal-A/opal-CT transition is documented by the concentration depth profiles of dissolved silica and lithium. Dolomitization precedes the opal-A/opal-CT transition at both sites. Kita-Yamato Trough sediments show an abrupt change in the compositional character of the pore fluids below 435 mbsf, which coincides with the occurrence of low porosity and high bulk density layers composed of dolomite and opal-CT. These layers impede to some extent diffusional communication with the overlying interstitial waters. The interstitial waters in sediments below 435 mbsf have chloride concentrations of 504-515 mM, significantly lower than that of modern day Japan Sea water (540 mM). The presence of low chloride waters within Miocene age sediments may indicate: (1) diagenetic reactions that involve the release of exchangeable and structural bound water from clay minerals and/or opal-A, (2) Miocene connate brackish lake water, (3) phase separation of hydrothermal fluids associated with rifting, (4) potential effects of clay membrane filtration in a high pressure zone.

  2. A rare mosaic interstitial deletion of 7q, 46,XX/46,XX,del(7)(q22.1q31.33), results in a mild clinical phenotype

    SciTech Connect

    Shapira, S.K.; Kochanek, S.; Shaffer, L.G.

    1994-09-01

    Constitutional mosaic structural rearrangements, including deletions, are extremely rare in the population. We present a case of mosaicism for a deletion of chromosome 7q. The patient`s phenotype is much milder than that of non-mosaic patients with a similar deletion of 7q. A 6 and 9/12-year-old Caucasian girl was evaluated because of attention deficit disorder and speech delay. She was born at 38 weeks gestation to her 37 year old G2P2 mother. Her birth weight was 2.2 kg (3rd centile), length was 47 cm (10th-25th centile), and OFC was 30.5 cm (<10th centile). Her motor development was normal. Her speech development was profoundly delayed with her first words spoken at 3 years, and 2-3 word sentences spoken at 5-6 years. At 6 and 9/12 years, she manifested mild mental retardation and profound speech delay, but only mildly dysmorphic features (protuberant ears with under-developed antihelices, flattened forehead, moderate micro-retrognathia). Height, weight, and OFC were at the 10th centile. Chromosomal analysis showed the presence of two cell lines, with 66% of the lymphocytes having a 46,XX pattern and 33% having a 46,XX,del(7)(q22.1q31.33) karyotype. Less than 20 cases of interstitial 7q deletions extending from bands 7q21 or 7q22 to 7q31 or 7q32 have been reported. Our patient represents the first documented case with a mosaic interstitial deletion of chromosome 7q. Furthermore, the deletion resulted in a relatively mild phenotype when compared to reported non-mosaic interstitial 7q deletions, and thus expands the range of clinical heterogeneity that can be anticipated in interstitial deletion patients.

  3. The use of directional interstitial sources to improve dosimetry in breast brachytherapy

    SciTech Connect

    Lin Liyong; Patel, Rakesh R.; Thomadsen, Bruce R.; Henderson, Douglass L.

    2008-01-15

    The purposes of this study were to investigate the feasibility of improving dosimetry with temporary low-dose-rate (LDR) multicatheter breast implants using directional {sup 125}I (iodine) interstitial sources and to provide a comparison of a patient treatment plan to that achieved by conventional high-dose-rate (HDR) interstitial breast brachytherapy. A novel {sup 125}I source emitting radiation in a specified direction has been developed. The directional sources contain an internal radiation shield that greatly reduces the intensity of radiation in the shielded direction. The sources have a similar dose distribution to conventional nondirectional sources on the unshielded side. The treatment plan for a patient treated with HDR interstitial brachytherapy with {sup 192}Ir (iridium) was compared with a directional {sup 125}I treatment plan using the same data set. Several dosimetric parameters are compared including target volume coverage, volume receiving 50%, 100%, and 150% of the prescription dose (V50, V100, and V150, respectively), dose homogeneity index (DHI), and the skin surface areas receiving 30%, 50%, and 80% of the prescription dose (S30, S50, and S80, respectively). The HDR and LDR prescription doses were 34 Gy in ten fractions delivered over five days and 45 Gy in 108 h, respectively. Similar and excellent target volume coverage was achieved by both directional LDR and HDR plans (99.2% and 97.5%, respectively). For a 170 cm{sup 3} target volume, the dosimetric parameters were similar for LDR and HDR: DHI was 0.82 in both cases, V100 was 214.4 cm{sup 3} and 225.7 cm{sup 3}, and V150 was 39.1 cm{sup 3} and 40.4 cm{sup 3}, respectively. However, with directional LDR, significant reductions in skin dose were achieved: S30 was reduced from 100.6 to 62.5 cm{sup 2}, S50 from 50.6 to 16.1 cm{sup 2}, and S80 from 2 cm{sup 2} to zero. The reduction in V50 for the whole breast was more than 100 cm{sup 3} (386.1 cm{sup 3} for LDR versus 489.2 cm{sup 3} for HDR

  4. Physical asymmetry of the crystallographic texture of an interstitial-free sheet steel

    SciTech Connect

    Hook, R.E. . Armco Research and Technology)

    1993-09-01

    The texture of a mill-produced, Nb-bearing, interstitial-free, hot-rolled sheet steel was evaluated at a number of sheet thickness positions. The texture was also studied following laboratory cold rolling and following recrystallization. A nonsymmetric case crystallite orientation distribution function analysis applicable to the analysis on nonsymmetric pole figures was used. While sheet steels are generally assumed to have orthotropic physical symmetry, it was found that an appreciable degree of physical asymmetry existed. The asymmetry was with respect to the rolling direction (RD) and normal direction (ND) mirror planes, while transverse direction (TD) mirror-plane symmetry existed.

  5. Reports

    Office of Legacy Management (LM)

    aehsed herewith ia Coaprehenaive Survey of USBEC mtp, Lewebldinge ad G~r~n&-owned Bpipment under SC & COntraCtCW'S COntrOl, as requested in AEC BULLETIN No. 48 dated April 26, 1917. .& Inols. Reports 10 acres NO. 5412 5435 5436 5421 5621 5432 5433 5434 5431 5437 Pipe Shop /j LOCATION Ij ij 88 1 / j Lske 'OntsTis Tohawanda !IS AEC Ordndnce 'Worki, Sllkffiqe ,Model wty, ,New York '8 I' j, i/ DESCRIPTION !! OF TT 'fro1 heti TX-2 fron inec s3n Die ylaed Ialst JS Eng- 1, 3x38 *ict 23, 144

  6. Reports

    Office of Legacy Management (LM)

    Reports . . . . , Book -1. Service Open File Information for Project Rulison, Production Testing Phase, . , August 28,1970 : . "; DISCLAIMER Portions of this document may be illegible in electronic image products. Images are produced from the best available original document. DESCRIPTION O F PU1:T41C I-l!lkI,T;-1 SE1:VICh: 0P:SN F I L E INPOPt4ATION i[ ' 7 S&u-~%uestcrn E a d i o l o g i c a l H e a l t h 1,aboratol-p r? U. S. Depaieraent o f I l e a l t h ,. E d u c a t i o n aud

  7. Strength and formability of ultra-low-carbon Ti-IF steels[Interstitial Free

    SciTech Connect

    Jeong, W.C.

    2000-04-01

    Ultra-low-carbon interstitial free (IF) steel sheets bearing Ti and/or Nb have been extensively used for automotive panels because of superior formability and nonaging properties. It is well known that the interstitial elements such as C and N play important roles in the formability. The lower the contents of the C and N in steel, the better the formability of the steel. The demands for the steel with excellent formability from automotive industry will accelerate the progress in the steelmaking process, leading to the development of the ultra-low-carbon steel. With the advent and installation of improved vacuum degassing equipment in the steelmaking process, it is now possible to consistently produce ultra-low-carbon content of 0.002 to 0.005 wt pct. It is expected that in the near future, the C and N contents can be lowered to as low as 0.001 pct or less. This study is focused on strength and formability in the extremely ultra-low-carbon IF steels containing about 0.001 pct carbon.

  8. Effect of interstitials on tensile strength and creep in nanostructured Ni

    SciTech Connect

    Yin, W.M.; Whang, S.H. . E-mail: swhang@poly.edu; Mirshams, R.A.

    2005-01-10

    The tensile, creep and anelastic behavior of nanostructured nickel doped and un-doped with boron was investigated. Specimen material with an average grain size of around 30 nm produced by the pulse electrodeposition method contains impurities such as carbon, sulfur and boron. The interstitials content does not have notable impact on the tensile strength at room temperature and 373 K. But, at 473 K, the minor change in sulfur content from 0.03 to 0.061 at.% raises the ultimate strength by 150 MPa while the boron doping further improves the tensile strength. On the other hand, with increasing sulfur content in nanostructured Ni, the ductility decreases. All the specimens exhibit significant anelastic relaxation from room temperature to 473 K. The creep test results show that both minimum creep rate and creep strain significantly decrease with increasing sulfur or by doping boron in nanostructured nickel. The stress exponent in the expression of Coble-type creep increases to around five at 373 and 473 K from two at room temperature. A model for grain boundary sliding, in which grain boundary dislocations and back stress are introduced, has successfully explained the large stress exponents. The calculated back stress indicates that the interstitials in grain boundaries effectively retard the sliding of grain boundary dislocations.

  9. Library of Congress Catalogingin-Publication Data

    Office of Scientific and Technical Information (OSTI)

    interstitial therapy. p. "Issued: 1 August 1997." cm. - (ICRU report ; 58) Includes ... Quality Clinical Proton Dosimetry - Part 11: Dose Specification for Dose and Volume ...

  10. Most Viewed Documents for Biology and Medicine: December 2014...

    Office of Scientific and Technical Information (OSTI)

    Most Viewed Documents for Biology and Medicine: December 2014 Dose and volume specification for reporting interstitial therapy NONE (1997) 38 Modification to the Monte Carlo ...

  11. Most Viewed Documents for Biology and Medicine: December 2014...

    Office of Scientific and Technical Information (OSTI)

    Dose and volume specification for reporting interstitial therapy NONE (1997) 38 Modification to the Monte Carlo N-Particle (MCNP) Visual Editor (MCNPVised) to Read in Computer ...

  12. Correlation between the electronic structures and diffusion paths of interstitial defects in semiconductors: The case in CdTe

    SciTech Connect

    Ma, Jie; Yang, Jihui; Da Silva, J. L.F.; Wei, Su-Huai

    2014-10-30

    Using first-principles calculations, we study the diffusions of interstitial defects Cd, Cu, Te, and Cl in CdTe. We find that the diffusion behavior is strongly correlated with the electronic structure of the interstitial diffuser. For Cd and Cu, because the defect state is the non-degenerated slike state under Td symmetry, the diffusions are almost along the [111] directions between the tetrahedral sites, although the diffusion of Cu shows some deviation due to the s - d coupling. The diffusions of the neutral and charged Cd and Cu follow similar paths. However, for Te and Cl atoms, because the defect state is the degenerated p-like state under Td symmetry, large distortions occur. Therefore, the diffusion paths are very different from those of Cd and Cu interstitials, and depend strongly on the charge states of the interstitial atoms. For Te, we find that the distortion is mostly stabilized by the crystal-field splitting, but for Cl, the exchange splitting plays a more important role.

  13. Correlation between the electronic structures and diffusion paths of interstitial defects in semiconductors: The case in CdTe

    DOE PAGES [OSTI]

    Ma, Jie; Yang, Jihui; Da Silva, J. L.F.; Wei, Su-Huai

    2014-10-30

    Using first-principles calculations, we study the diffusions of interstitial defects Cd, Cu, Te, and Cl in CdTe. We find that the diffusion behavior is strongly correlated with the electronic structure of the interstitial diffuser. For Cd and Cu, because the defect state is the non-degenerated slike state under Td symmetry, the diffusions are almost along the [111] directions between the tetrahedral sites, although the diffusion of Cu shows some deviation due to the s - d coupling. The diffusions of the neutral and charged Cd and Cu follow similar paths. However, for Te and Cl atoms, because the defect statemore » is the degenerated p-like state under Td symmetry, large distortions occur. Therefore, the diffusion paths are very different from those of Cd and Cu interstitials, and depend strongly on the charge states of the interstitial atoms. For Te, we find that the distortion is mostly stabilized by the crystal-field splitting, but for Cl, the exchange splitting plays a more important role.« less

  14. Influence of Noncompliance With Radiation Therapy Protocol Guidelines and Operative Bed Recurrences for Children With Rhabdomyosarcoma and Microscopic Residual Disease: A Report From the Children's Oncology Group

    SciTech Connect

    Million, Lynn; Anderson, James; Breneman, John; Hawkins, Douglas S.; Laurie, Fran; Michalski, Jeff; Rodeberg, David; Wharam, Moody; Wolden, Suzanne; Donaldson, Sarah S.

    2011-06-01

    Purpose: Postoperative radiation therapy (RT) is recommended for patients with rhabdomyosarcoma having microscopic disease. Sometimes RT dose/volume is reduced or omitted in an attempt to avoid late effects, particularly in young children. We reviewed operative bed recurrences to determine if noncompliance with RT protocol guidelines influenced local-regional control. Methods and Materials: All operative bed recurrences among 695 Group II rhabdomyosarcoma patients in Intergroup Rhabdomyosarcoma Study Group (IRS) I through IV were reviewed for deviation from RT protocol. Major/minor dose deviation was defined as >10% or 6-10% of the prescribed dose (40-60 Gy), respectively. Major/minor volume deviation was defined as tumor excluded from the RT field or treatment volume not covered by the specified margin (preoperative tumor volume and 2- to 5-cm margin), respectively. No RT was a major deviation. Results: Forty-six of 83 (55%) patients with operative bed recurrences did not receive the intended RT (39 major and 7 minor deviations). RT omission was the most frequent RT protocol deviation (19/46, 41%), followed by dose (17/46, 37%), volume (9/46, 20%), and dose and volume deviation (1/46, 2%). Only 7 operative bed recurrences occurred in IRS IV (5% local-regional failure) with only 3 RT protocol deviations. Sixty-three (76%) patients with recurrence died of disease despite retrieval therapy, including 13 of 19 nonirradiated children. Conclusion: Over half of the operative bed recurrences were associated with noncompliance; omission of RT was the most common protocol deviation. Three fourths of children die when local-regional disease is not controlled, emphasizing the importance of RT in Group II rhabdomyosarcoma.

  15. Quality Assurance of Multifractionated Pelvic Interstitial Brachytherapy for Postoperative Recurrences of Cervical Cancers: A Prospective Study

    SciTech Connect

    Shukla, Pragya; Chopra, Supriya; Engineer, Reena; Mahantshetty, Umesh; Paul, Siji Nojin; Phurailatpam, Reena; SV, Jamema; Shrivastava, Shyam K.

    2012-03-15

    Purpose: To evaluate three-dimensional needle displacements during multifractionated interstitial brachytherapy (BT) for cervical cancers. Methods and Materials: Patients scheduled to undergo pelvic interstitial BT for postoperative and or postradiation vault recurrences were included from November 2009 to December 2010. All procedures were performed under spinal anesthesia. Postprocedure BT planning CT scans were obtained with patients in supine position with arms on the chest (interslice thickness of 3 mm). Thereafter, verification CT was repeated at every alternate fraction. Needle displacements were measured in reference to a relocatable bony point. The mean cranial, caudal, anteroposterior, and mediolateral displacements were recorded. Statistical significance of mean interfraction displacements was evaluated with Wilcoxon Test. Results: Twenty patients were included. Seventeen received boost BT (20 Gy/5 fractions/3 days) after external radiation, three received radical BT alone (36 Gy/9 fractions/5-8 days). An average of three scans (range, 2-3) were available per patient, and 357 needle displacements were analyzed. For the entire study cohort, the average of mean needle displacement was 2.5 mm (range, 0-7.4), 17.4 mm (range, 0-27.9), 1.7 mm (range, 0-6.7), 2.1 mm (range, 0-9.5), 1.7 mm (range, 0-9.3), and 0.6 mm (range, 0-7.8) in cranial, caudal, anterior, posterior, right, and left directions, respectively. The mean displacement in the caudal direction was higher between Days 1 and 2 than that between Days 2 and 3 (13.4 mm vs. 3.8 mm; p = 0.01). The average caudal displacements were no different between reirradiation and boost cohort (15.2 vs. 17.8 mm). Conclusions: Clinically significant caudal displacements occur during multifractionated pelvic brachytherapy. Optimal margins need to be incorporated while preplanning brachytherapy to account for interfraction displacements.

  16. Patterns of Relapse From a Phase 3 Study of Response-Based Therapy for Intermediate-Risk Hodgkin Lymphoma (AHOD0031): A Report From the Children's Oncology Group

    SciTech Connect

    Dharmarajan, Kavita V.; Friedman, Debra L.; Schwartz, Cindy L.; Chen, Lu; FitzGerald, T.J.; McCarten, Kathleen M.; Constine, Louis S.; Wolden, Suzanne L.

    2015-05-01

    Purpose: The study was designed to determine whether response-based therapy improves outcomes in intermediate-risk Hodgkin lymphoma. We examined patterns of first relapse in the study. Patients and Methods: From September 2002 to July 2010, 1712 patients <22 years old with stage I-IIA with bulk, I-IIAE, I-IIB, and IIIA-IVA with or without doxorubicin, bleomycin, vincristine, etoposide, prednisone, and cyclophosphamide were enrolled. Patients were categorized as rapid (RER) or slow early responders (SER) after 2 cycles of doxorubicin, bleomycin, vincristine, etoposide, prednisone, and cyclophosphamide (ABVE-PC). The SER patients were randomized to 2 additional ABVE-PC cycles or augmented chemotherapy with 21 Gy involved field radiation therapy (IFRT). RER patients were stipulated to undergo 2 additional ABVE-PC cycles and were then randomized to 21 Gy IFRT or no further treatment if complete response (CR) was achieved. RER without CR patients were non-randomly assigned to 21 Gy IFRT. Relapses were characterized without respect to site (initial, new, or both; and initial bulk or initial nonbulk), and involved field radiation therapy field (in-field, out-of-field, or both). Patients were grouped by treatment assignment (SER; RER/no CR; RER/CR/IFRT; and RER/CR/no IFRT). Summary statistics were reported. Results: At 4-year median follow-up, 244 patients had experienced relapse, 198 of whom were fully evaluable for review. Those who progressed during treatment (n=30) or lacked relapse imaging (n=16) were excluded. The median time to relapse was 12.8 months. Of the 198 evaluable patients, 30% were RER/no CR, 26% were SER, 26% were RER/CR/no IFRT, 16% were RER/CR/IFRT, and 2% remained uncategorized. The 74% and 75% relapses involved initially bulky and nonbulky sites, respectively. First relapses rarely occurred at exclusively new or out-of-field sites. By contrast, relapses usually occurred at nodal sites of initial bulky and nonbulky disease. Conclusion: Although

  17. Dosimetric Consequences of Interobserver Variability in Delineating the Organs at Risk in Gynecologic Interstitial Brachytherapy

    SciTech Connect

    Damato, Antonio L.; Bair, Ryan J.; Cormack, Robert A.; Kovacs, Arpad; Lee, Larissa J.; Lewis, John H.; Viswanathan, Akila N.

    2014-07-01

    Purpose: To investigate the dosimetric variability associated with interobserver organ-at-risk delineation differences on computed tomography in patients undergoing gynecologic interstitial brachytherapy. Methods and Materials: The rectum, bladder, and sigmoid of 14 patients treated with gynecologic interstitial brachytherapy were retrospectively contoured by 13 physicians. Geometric variability was calculated using κ statistics, conformity index (CI{sub gen}), and coefficient of variation (CV) of volumes contoured across physicians. Dosimetric variability of the single-fraction D{sub 0.1cc} and D{sub 2cc} was assessed through CV across physicians, and the standard deviation of the total EQD2 (equivalent dose in 2 Gy per fraction) brachytherapy dose (SD{sup TOT}) was calculated. Results: The population mean ± 1 standard deviation of κ, CI{sub gen}, and volume CV were, respectively: 0.77 ± 0.06, 0.70 ± 0.08, and 20% ± 6% for bladder; 0.74 ± 06, 0.67 ± 0.08, and 20% ± 5% for rectum; and 0.33 ± 0.20, 0.26 ± 0.17, and 82% ± 42% for sigmoid. Dosimetric variability was as follows: for bladder, CV = 31% ± 19% (SD{sup TOT} = 72 ± 64 Gy) for D{sub 0.1cc} and CV = 16% ± 10% (SD{sup TOT} = 9 ± 6 Gy) for D{sub 2cc}; for rectum, CV = 11% ± 5% (SD{sup TOT} = 16 ± 17 Gy) for D{sub 0.1cc} and CV = 7% ± 2% (SD{sup TOT} = 4 ± 3 Gy) for D{sub 2cc}; for sigmoid, CV = 39% ± 28% (SD{sup TOT} = 12 ± 18 Gy) for D{sub 0.1cc} and CV = 34% ± 19% (SD{sup TOT} = 4 ± 4 Gy) for D{sub 2cc.} Conclusions: Delineation of bladder and rectum by 13 physicians demonstrated substantial geometric agreement and resulted in good dosimetric agreement for all dose-volume histogram parameters except bladder D{sub 0.1cc.} Small delineation differences in high-dose regions by the posterior bladder wall may explain these results. The delineation of sigmoid showed fair geometric agreement. The higher dosimetric variability for sigmoid compared with rectum and bladder did not correlate with

  18. Modeling Local Control After Hypofractionated Stereotactic Body Radiation Therapy for Stage I Non-Small Cell Lung Cancer: A Report From the Elekta Collaborative Lung Research Group

    SciTech Connect

    Ohri, Nitin; Werner-Wasik, Maria; Grills, Inga S.; Belderbos, Jose; Hope, Andrew; Yan Di; Kestin, Larry L.; Guckenberger, Matthias; Sonke, Jan-Jakob; Bissonnette, Jean-Pierre; Xiao, Ying

    2012-11-01

    Purpose: Hypofractionated stereotactic body radiation therapy (SBRT) has emerged as an effective treatment option for early-stage non-small cell lung cancer (NSCLC). Using data collected by the Elekta Lung Research Group, we generated a tumor control probability (TCP) model that predicts 2-year local control after SBRT as a function of biologically effective dose (BED) and tumor size. Methods and Materials: We formulated our TCP model as follows: TCP = e{sup [BED10-c Asterisk-Operator L-TCD50]/k} Division-Sign (1 + e{sup [BED10-c Asterisk-Operator L-TCD50]/k}), where BED10 is the biologically effective SBRT dose, c is a constant, L is the maximal tumor diameter, and TCD50 and k are parameters that define the shape of the TCP curve. Least-squares optimization with a bootstrap resampling approach was used to identify the values of c, TCD50, and k that provided the best fit with observed actuarial 2-year local control rates. Results: Data from 504 NSCLC tumors treated with a variety of SBRT schedules were available. The mean follow-up time was 18.4 months, and 26 local recurrences were observed. The optimal values for c, TCD50, and k were 10 Gy/cm, 0 Gy, and 31 Gy, respectively. Thus, size-adjusted BED (sBED) may be defined as BED minus 10 times the tumor diameter (in centimeters). Our TCP model indicates that sBED values of 44 Gy, 69 Gy, and 93 Gy provide 80%, 90%, and 95% chances of tumor control at 2 years, respectively. When patients were grouped by sBED, the model accurately characterized the relationship between sBED and actuarial 2-year local control (r=0.847, P=.008). Conclusion: We have developed a TCP model that predicts 2-year local control rate after hypofractionated SBRT for early-stage NSCLC as a function of biologically effective dose and tumor diameter. Further testing of this model with additional datasets is warranted.

  19. The structures of interstitial hydrogen centers in VO2 in the dilute limit from their vibrational properties and theory

    DOE PAGES [OSTI]

    Yin, W.; Qin, Ying; Fowler, W. B.; Stavola, M.; Boatner, Lynn A.

    2016-07-28

    The introduction of a large concentration of H into VO2 is known to suppress the insulating phase of the metal-insulator transition that occurs upon cooling below 340 K. We have used infrared spectroscopy and complementary theory to study the properties of interstitial H and D in VO2 in the dilute limit to determine the vibrational frequencies, thermal stabilities, and equilibrium positions of isolated interstitial H and D centers. The vibrational lines of several OH and OD centers were observed to have thermal stabilities similar to that of the hydrogen that suppresses the insulating phase. Theory associates two of the fourmore » possible OH configurations for Hi in the insulating VO2 monoclinic phase with OH lines seen by experiment. Furthermore, theory predicts the energies and vibrational frequencies for configurations with Hi trapped near a substitutional impurity and suggests such defects as candidates for additional OH centers that have been observed.« less

  20. Mixed ligand chelate therapy for plutonium and toxic metals from energy power production. Final report, April 15, 1977-October 14, 1980. [Mice

    SciTech Connect

    Schubert, J.

    1980-10-14

    The results of experiments are summarized on the ability of combinations of chelating agents to modify the genotoxicity or tissue distributions. The mutagenicities of Cr and of chelating agents were determined. The metals described in the report are Pu(IV), Cd(II), Cr(III), and Cr(VI). Accurate measurements were made of the ability of CaNa/sub 2/EDTA, CaNa/sub 3/DTPA, and DMPS to reduce mortality in mice given doses (i.p.) of CdCl/sub 2/ well above the 100% lethal level. The efficacy in terms of the mmoles/kg needed to reduce the mortality was: DTPA > EDTA > DMPS. The combination of DTPA + DMPS proved most promising though little evidence for mixed complex formation was noted. Potentiometric titration studies the case of Pu(IV) a few combinations proved effective, but only when given shortly after Pu administration and then only in the liver but not the skeleton. It is recommended that metabolically stable chelating agents be used in combinations, especially for those combinations which may form very stable mixed ligand chelates.

  1. Analysis of Interstitial Elements in Niobium with Secondary Ion Mass Spectrometry (SIMS)

    SciTech Connect

    Maheshwari, P.; Griffis, D. P.; Stevie, F. A.; Myeneni, G.; Ciovati, G.; Rigsbee, J. M.

    2011-03-31

    Superconducting Radio Frequency (SRF) cavities provide enhanced efficiency and reduced energy utilization in present day particle accelerators. Niobium (Nb) is the material of choice for these cavities due to its high critical temperature and critical magnetic field. In order to understand why certain treatments, especially a low temperature bake, improve performance, it is important to study Nb surface characteristics and identify elemental contamination that can affect the performance of the cavity. H, C, O, and N are of interest because they are interstitial impurities in Nb. In earlier work, SIMS analysis using a CAMECA IMS-6F with Cs{sup +} primary beam showed that C and N were probably not significant factors impacting performance but there was a very high level of H in the Nb. Ion implants of C, N, O, and D into Nb provided quantification of C, N, O and indicated that D is very mobile in the Nb. Further analyses showed that heat treated Nb has lower levels of surface H than non heat treated Nb and subsequent removal of surface oxide by etching causes intake of H in a heat treated Nb sample. This result helps confirm the role of surface oxide as a hydrogen barrier. To further understand the oxide, Nb samples were anodized to obtain a thicker surface oxide and H and D were implanted into this oxide to check for the appearance of implant peaks. SIMS depth profile analyses were carried out and confirmed the presence of the implant shape for these elements in the oxide. Relative Sensitivity Factor (RSFs) could then be calculated for quantification of H in the oxide. Since the Nb matrix signal showed little change from the oxide to the substrate, the same RSF was used to estimate the H concentration in the Nb at 2x10{sup 22} atoms/cm{sup 3}(approximately 40% mole fraction H).

  2. Noncirrhotic portal fibrosis after Wilms' tumor therapy

    SciTech Connect

    Barnard, J.A.; Marshall, G.S.; Neblett, W.W.; Gray, G.; Ghishan, F.K.

    1986-04-01

    A 9-yr-old girl developed massive hemorrhage from esophageal varices 2 yr after combined modality therapy for Wilms' tumor. Evaluation showed a patent extrahepatic portal venous system and an elevated splenic pulp pressure. In contrast to previous reports of hepatopathy after irradiation injury, histologic sections of the liver did not demonstrate occlusion of the central veins, but rather a diffuse obliteration of intrahepatic portal venous radicles. This pattern of noncirrhotic portal fibrosis has not been described following antitumor therapy.

  3. Imaging Tumor Variation in Response to Photodynamic Therapy in Pancreatic Cancer Xenograft Models

    SciTech Connect

    Samkoe, Kimberley S.; Chen, Alina; Rizvi, Imran; O'Hara, Julia A.; Hoopes, P. Jack; Pereira, Stephen P.; Hasan, Tayyaba; Pogue, Brian W.

    2010-01-15

    Purpose: A treatment monitoring study investigated the differential effects of orthotopic pancreatic cancer models in response to interstitial photodynamic therapy (PDT), and the validity of using magnetic resonance imaging as a surrogate measure of response was assessed. Methods and Materials: Different orthotopic pancreatic cancer xenograft models (AsPC-1 and Panc-1) were used to represent the range of pathophysiology observed in human beings. Identical dose escalation studies (10, 20, and 40J/cm) using interstitial verteporfin PDT were performed, and magnetic resonance imaging with T2-weighted and T1-weighted contrast were used to monitor the total tumor volume and the vascular perfusion volume, respectively. Results: There was a significant amount of necrosis in the slower-growing Panc-1 tumor using high light dose, although complete necrosis was not observed. Lower doses were required for the same level of tumor kill in the faster-growing AsPC-1 cell line. Conclusions: The tumor growth rate and vascular pattern of the tumor affect the optimal PDT treatment regimen, with faster-growing tumors being relatively easier to treat. This highlights the fact that therapy in human beings shows a heterogeneous range of outcomes, and suggests a need for careful individualized treatment outcomes assessment in clinical work.

  4. Phase 3 Trial of Domiciliary Humidification to Mitigate Acute Mucosal Toxicity During Radiation Therapy for Head-and-Neck Cancer: First Report of Trans Tasman Radiation Oncology Group (TROG) 07.03 RadioHUM Study

    SciTech Connect

    Macann, Andrew; Fua, Tsien; Milross, Chris G.; Porceddu, Sandro V.; Penniment, Michael; Wratten, Chris; Krawitz, Hedley; Poulsen, Michael; Tang, Colin I.; Morton, Randall P.; Hay, K. David; Thomson, Vicki; Bell, Melanie L.; King, Madeleine T.; Fraser-Browne, Carol L.; Hockey, Hans-Ulrich P.

    2014-03-01

    Purpose: To assess the impact of domicile-based humidification on symptom burden during radiation therapy (RT) for head-and-neck (H and N) cancer. Methods and Materials: From June 2007 through June 2011, 210 patients with H and N cancer receiving RT were randomized to either a control arm or to receive humidification using the Fisher and Paykel Healthcare MR880 humidifier. Humidification commenced on day 1 of RT and continued until Common Terminology Criteria for Adverse Events (CTCAE), version 3.0, clinical mucositis (CMuc) grade ≤1 occurred. Forty-three patients (42%) met a defined benchmark for humidification compliance and contributed to per protocol (PP) analysis. Acute toxicities, hospitalizations, and feeding tube events were recorded prospectively. The McMaster University Head and Neck Radiotherapy Questionnaire (HNRQ) was used for patient-reported outcomes. The primary endpoint was area under the curve (AUC) for CMuc grade ≥2. Results: There were no significant differences in AUC for CMuc ≥2 between the 2 arms. Humidification patients had significantly fewer days in hospital (P=.017). In compliant PP patients, the AUC for CTCAE functional mucositis score (FMuc) ≥2 was significantly reduced (P=.009), and the proportion who never required a feeding tube was significantly greater (P=.04). HNRQ PP analysis estimates also in the direction favoring humidification with less symptom severity, although differences at most time points did not reach significance. Conclusions: TROG 07.03 has provided efficacy signals consistent with a role for humidification in reducing symptom burden from mucositis, but the influence of humidification compliance on the results moderates recommendations regarding its practical utility.

  5. Comparison of precipitate behaviors in ultra-low carbon, titanium-stabilized interstitial free steel sheets under different annealing processes

    SciTech Connect

    Shi, J.; Wang, X.

    1999-12-01

    Ultra-low carbon, titanium-stabilized interstitial free (ULC Ti-IF) steel sheets are widely used in the automobile industry because of excellent deep drawability. The annealing process is critical to their final property, and there are two different annealing processes used in industrial production of interstitial free (IF) steel sheets, namely batch annealing and continuous annealing. In this study, precipitation behaviors of titanium IF steels, that is, TiN, TiS, Ti{sub 4}(CS){sub 2}, and TiC, the size and dispersion of TiN, TiS, and Ti{sub 4}(CS){sub 2} remained almost unchanged after either annealing process. Conversely, the average size of a TiC particle increased substantially after both annealing processes, while TiC after continuous annealing was larger than that after batch annealing due to the higher heating temperature of continuous annealing. Two new particles, FeTiP and (Ti, Mn)S, were also observed in the batch annealing process but not in continuous annealing. The structure of FeTiP and (Ti, Mn)S were studied, and furthermore the evolution of FeTiP precipitation was found to be closely related to recrystallization in batch annealing. Finally, the interrelation among processing parameters, precipitation behaviors, and final property was studied.

  6. Structure, Stoichiometry and Stability in Magnetoplumbite and {beta}-Alumina Structured Type Ceramics. Final Report

    SciTech Connect

    Cormack, A. N.

    2004-03-01

    Work has been completed on the atomistic simulation of hexa-aluminate ceramics with the magnetoplumbite and beta-alumina type structures. In this report, three aspects of the work are highlighted. One is the simulation of surface structures. The second concerns details of the interstitially mechanisms observed in molecular dynamics simulations. The novel result here is the observation that the lattice ion always leaves its Beevers-Ross site before the aBR interstitial begins to move towards the lattice site. It is also found that, as expected, the interstitial mechanism is the most common mechanism in the heavily disordered nonstoichiometric structure, as well as in the stoichiometric material. Finally, the disposition of trivalent europium in the phosphor material BAM has been elucidated.

  7. Accelerators for Cancer Therapy

    DOE R&D Accomplishments

    Lennox, Arlene J.

    2000-05-30

    The vast majority of radiation treatments for cancerous tumors are given using electron linacs that provide both electrons and photons at several energies. Design and construction of these linacs are based on mature technology that is rapidly becoming more and more standardized and sophisticated. The use of hadrons such as neutrons, protons, alphas, or carbon, oxygen and neon ions is relatively new. Accelerators for hadron therapy are far from standardized, but the use of hadron therapy as an alternative to conventional radiation has led to significant improvements and refinements in conventional treatment techniques. This paper presents the rationale for radiation therapy, describes the accelerators used in conventional and hadron therapy, and outlines the issues that must still be resolved in the emerging field of hadron therapy.

  8. Roles of Vacancy/Interstitial Diffusion and Segregation in the Microchemistry at Grain Boundaries of Irradiated Fe-Cr-Ni alloys

    DOE PAGES [OSTI]

    Yang, Ying; Field, Kevin G.; Allen, Todd R.; Busby, Jeremy T.

    2016-02-23

    A detailed analysis of the diffusion fluxes near and at grain boundaries of irradiated Fe–Cr–Ni alloys, induced by preferential atom-vacancy and atom-interstitial coupling, is presented. The diffusion flux equations were based on the Perks model formulated through the linear theory of the thermodynamics of irreversible processes. The preferential atom-vacancy coupling was described by the mobility model, whereas the preferential atom-interstitial coupling was described by the interstitial binding model. The composition dependence of the thermodynamic factor was modeled using the CALPHAD approach. The calculated fluxes up to 10 dpa suggested the dominant diffusion mechanism for chromium and iron is via vacancy,more » while that for nickel can swing from the vacancy to the interstitial dominant mechanism. The diffusion flux in the vicinity of a grain boundary was found to be greatly modified by the segregation induced by irradiation, leading to the oscillatory behavior of alloy compositions in this region.« less

  9. Simulation of xenon, uranium vacancy and interstitial diffusion and grain boundary segregation in UO2

    SciTech Connect

    Andersson, Anders D.; Tonks, Michael R.; Casillas, Luis; Nerikar, Pankaj; Vyas, Shyam; Uberuaga, Blas P.; Stanek, Christopher R.

    2014-10-31

    In light water reactor fuel, gaseous fission products segregate to grain boundaries, resulting in the nucleation and growth of large intergranular fission gas bubbles. Based on the mechanisms established from density functional theory (DFT) and empirical potential calculations 1, continuum models for diffusion of xenon (Xe), uranium (U) vacancies and U interstitials in UO2 have been derived for both intrinsic conditions and under irradiation. Segregation of Xe to grain boundaries is described by combining the bulk diffusion model with a model for the interaction between Xe atoms and three different grain boundaries in UO2 ( Σ5 tilt, Σ5 twist and a high angle random boundary),as derived from atomistic calculations. All models are implemented in the MARMOT phase field code, which is used to calculate effective Xe and U diffusivities as well as redistribution for a few simple microstructures.

  10. First-principles multiple-barrier diffusion theory. The case study of interstitial diffusion in CdTe

    SciTech Connect

    Yang, Ji -Hui; Park, Ji -Sang; Kang, Joongoo; Wei, Su -Huai

    2015-02-17

    The diffusion of particles in solid-state materials generally involves several sequential thermal-activation processes. However, presently, diffusion coefficient theory only deals with a single barrier, i.e., it lacks an accurate description to deal with multiple-barrier diffusion. Here, we develop a general diffusion coefficient theory for multiple-barrier diffusion. Using our diffusion theory and first-principles calculated hopping rates for each barrier, we calculate the diffusion coefficients of Cd, Cu, Te, and Cl interstitials in CdTe for their full multiple-barrier diffusion pathways. As a result, we found that the calculated diffusivity agrees well with the experimental measurement, thus justifying our theory, which is general for many other systems.

  11. First-principles multiple-barrier diffusion theory. The case study of interstitial diffusion in CdTe

    DOE PAGES [OSTI]

    Yang, Ji -Hui; Park, Ji -Sang; Kang, Joongoo; Wei, Su -Huai

    2015-02-17

    The diffusion of particles in solid-state materials generally involves several sequential thermal-activation processes. However, presently, diffusion coefficient theory only deals with a single barrier, i.e., it lacks an accurate description to deal with multiple-barrier diffusion. Here, we develop a general diffusion coefficient theory for multiple-barrier diffusion. Using our diffusion theory and first-principles calculated hopping rates for each barrier, we calculate the diffusion coefficients of Cd, Cu, Te, and Cl interstitials in CdTe for their full multiple-barrier diffusion pathways. As a result, we found that the calculated diffusivity agrees well with the experimental measurement, thus justifying our theory, which is generalmore » for many other systems.« less

  12. Formation of shallow boron emitters in crystalline silicon using flash lamp annealing: Role of excess silicon interstitials

    SciTech Connect

    Riise, Heine Nygard Azarov, Alexander; Svensson, Bengt G.; Monakhov, Edouard

    2015-07-13

    Shallow, Boron (B)-doped p{sup +} emitters have been realized using spin-on deposition and Flash Lamp Annealing (FLA) to diffuse B into monocrystalline float zone Silicon (Si). The emitters extend between 50 and 140 nm in depth below the surface, have peak concentrations between 9 × 10{sup 19 }cm{sup –3} and 3 × 10{sup 20 }cm{sup –3}, and exhibit sheet resistances between 70 and 3000 Ω/□. An exceptionally large increase in B diffusion occurs for FLA energy densities exceeding ∼93 J/cm{sup 2} irrespective of 10 or 20 ms pulse duration. The effect is attributed to enhanced diffusion of B caused by Si interstitial injection following a thermally activated reaction between the spin-on diffusant film and the silicon wafer.

  13. In-Situ Characterization of Cloud Condensation Nuclei, Interstitial, and background Particles using Single Particle Mass Spectrometer, SPLAT II

    SciTech Connect

    Zelenyuk, Alla; Imre, D.; Earle, Michael; Easter, Richard C.; Korolev, Alexei; Leaitch, W. R.; Liu, Peter; Macdonald, A. M.; Ovchinnikov, Mikhail; Strapp, Walter

    2010-10-01

    Aerosol indirect effect remains the most uncertain aspect of climate change modeling because proper test requires knowledge of individual particles sizes and compositions with high spatial and temporal resolution. We present the first deployment of a single particle mass spectrometer (SPLAT II) that is operated in a dual data acquisition mode to measure all the required individual particle properties with sufficient temporal resolution to definitively resolve the aerosol-cloud interaction in this exemplary case. We measured particle number concentrations, asphericity, and individual particle size, composition, and density with better than 60 seconds resolution. SPLAT II measured particle number concentrations between 70 particles cm-3and 300 particles cm-3, an average particle density of 1.4 g cm-3. Found that most particles are composed of oxygenated organics, many of which are mixed with sulfates. Biomass burn particles some with sulfates were prevalent, particularly at higher altitudes, and processed sea-salt was observed over the ocean. Analysis of cloud residuals shows that with time cloud droplets acquire sulfate by the reaction of peroxide with SO2. Based on the particle mass spectra and densities we find that the compositions of cloud condensation nuclei are similar to those of background aerosol but, contain on average ~7% more sulfate, and do not include dust and metallic particles. A comparison between the size distributions of background, activated, and interstitial particles shows that while nearly none of the activated particles is smaller than 115 nm, more than 80% of interstitial particles are smaller than 115 nm. We conclude that for this cloud the most important difference between CCN and background aerosol is particle size although having more sulfate also helps.

  14. De novo interstitial tandem duplication of chromosome 4(q21-q28)

    SciTech Connect

    Navarro, E.G.; Ramon, F.J.H.; Jimenez, R.D.

    1996-03-29

    We describe a girl with a previously unreported de novo duplication of chromosome 4q involving segment q21-q28. Clinical manifestations included growth and psychomotor retardation, facial asymmetry, hypotelorism, epicanthic folds, mongoloid slant of palpebral fissures, apparently low-set auricles, high nasal bridge, long philtrum, small mouth, short neck, low-set thumbs, and bilateral club foot. This phenotype is compared with that of previously reported cases of duplication 4q. 12 refs., 3 figs., 1 tab.

  15. De novo interstitial deletions of 9q22.1-22.3 in two unrelated cases with different phenotype

    SciTech Connect

    Mohamed, A.N.; Bawle, E.; Conard, J.

    1994-09-01

    Deletions involving the long arm of chromosome 9 are rare. A recent review, particularly with deletions of 9q22-32 region, failed to recognize a distinct pattern of dysmorphies and malformations. Herein, we described two phenotypically abnormal unrelated cases with interstitial deletion of chromosome 9 at band q22.1-q22.3. Parents of both cases exhibited normal karyotypes, indicating that the deletions were de novo events. Therefore, the clinical features present in these two cases can be attributed to partial monosomy for the deleted band 9q22. The first case was a 2-day-old baby with ambiguous genitalia, hydrocephalus, cleft palate and lip, polycystic kidney, absence of uterus on ultrasound and one gonad in the labiosacral region. Chromosome analysis showed a male karyotype, 46,XY,del(9)(q22.1q22.3). The absence of monosomy X cell line and the normal histology of testicular tissue were against the diagnosis of mixed gonadal dysgenesis or XY gonadal dysgenesis. The second 3-day-old newborn baby girl presented with right side hypoplastic heart and pulmonary atresia. In addition, the patient showed multiple dysmorphic features including epicanthal fold, low-set ears, depressed nasal bridge, hypertelorism, and micrognathia. The uvula is absent with slight cleft palate. Bilateral clinodactyly of 5th fingers and severe club feet were also present. The external genitalia was of a normal female phenotype. Chromosome study also indicated interstatial deletion of band 9q22. Although both cases appeared to have the same chromosomal anomalies, neither a discrete facial appearance nor a common pattern of malformations was noted.

  16. WE-G-17A-05: Real-Time Catheter Localization Using An Active MR Tracker for Interstitial Brachytherapy

    SciTech Connect

    Wang, W; Damato, A; Viswanathan, A; Cormack, R; Penzkofer, T; Schmidt, E; Pan, L; Gilson, W; Seethamraju, R

    2014-06-15

    Purpose: To develop a novel active MR-tracking system which can provide accurate and rapid localization of brachytherapy catheters, and assess its reliability and spatial accuracy in comparison to standard catheter digitization using MR images. Methods: An active MR tracker for brachytherapy was constructed by adding three printed-circuit micro-coils to the shaft of a commercial metallic stylet. A gel phantom with an embedded framework was built, into which fifteen 14-Gauge catheters were placed, following either with parallel or crossed paths. The tracker was inserted sequentially into each catheter, with MR-tracking running continuously. Tracking was also performed during the tracker's removal from each catheter. Catheter trajectories measured from the insertion and the removal procedures using the same micro-coil were compared, as well as trajectories obtained using different micro-coils. A 3D high-resolution MR image dataset of the phantom was acquired and imported into a treatment planning system (TPS) for catheter digitization. A comparison between MR-tracked positions and positions digitized from MR images by TPS was performed. Results: The MR tracking shows good consistency for varying catheter paths and for all micro-coils (mean difference ∼1.1 mm). The average distance between the MR-tracking trajectory and catheter digitization from the MR images was 1.1 mm. Ambiguity in catheter assignment from images due to crossed paths was resolved by active tracking. When tracking was interleaved with imaging, real-time images were continuously acquired at the instantaneous tip positions and displayed on an external workstation. Conclusion: The active MR tracker may be used to provide an independent measurement of catheter location in the MR environment, potentially eliminating the need for subsequent CT. It may also be used to control realtime imaging of catheter placement. This will enable MR-based brachytherapy planning of interstitial implants without ionizing

  17. Neutron capture therapies

    DOEpatents

    Yanch, Jacquelyn C.; Shefer, Ruth E.; Klinkowstein, Robert E.

    1999-01-01

    In one embodiment there is provided an application of the .sup.10 B(n,.alpha.).sup.7 Li nuclear reaction or other neutron capture reactions for the treatment of rheumatoid arthritis. This application, called Boron Neutron Capture Synovectomy (BNCS), requires substantially altered demands on neutron beam design than for instance treatment of deep seated tumors. Considerations for neutron beam design for the treatment of arthritic joints via BNCS are provided for, and comparisons with the design requirements for Boron Neutron Capture Therapy (BNCT) of tumors are made. In addition, exemplary moderator/reflector assemblies are provided which produce intense, high-quality neutron beams based on (p,n) accelerator-based reactions. In another embodiment there is provided the use of deuteron-based charged particle reactions to be used as sources for epithermal or thermal neutron beams for neutron capture therapies. Many d,n reactions (e.g. using deuterium, tritium or beryllium targets) are very prolific at relatively low deuteron energies.

  18. Recombination radius of a Frenkel pair and capture radius of a self-interstitial atom by vacancy clusters in bcc Fe

    DOE PAGES [OSTI]

    Nakashima, Kenichi; Stoller, Roger E.; Xu, Haixuan

    2015-01-01

    The recombination radius of a Frenkel pair is a fundamental parameter for the object kinetic Monte Carlo (OKMC) and mean field rate theory (RT) methods that are used to investigate irradiation damage accumulation in neutron irradiated nuclear materials. The recombination radius in bcc Fe has been studied both experimentally and numerically, however there is no general consensus about its value. The detailed atomistic processes of recombination also remain uncertain. Values from 1:0a₀ to 3:3a₀ have been employed as a recombination radius in previous studies using OKMC and RT. The recombination process of a Frenkel pair is investigated at the atomicmore » level using the self-evolved atomistic kinetic Monte Carlo (SEAKMC) method in this paper. SEAKMC calculations reveal that a self-interstitial atom recombines with a vacancy in a spontaneous reaction from several nearby sites following characteristic pathways. The recombination radius of a Frenkel pair is estimated to be 2.26a₀ by taking the average of the recombination distances from 80 simulation cases. This value agrees well with the experimental estimate. In addition, we apply these procedures to the capture radius of a self-interstitial atom by a vacancy cluster. The capture radius is found to gradually increase with the size of the vacancy cluster. The fitting curve for the capture radius is obtained as a function of the number of vacancies in the cluster.« less

  19. Recombination radius of a Frenkel pair and capture radius of a self-interstitial atom by vacancy clusters in bcc Fe

    SciTech Connect

    Nakashima, Kenichi; Stoller, Roger E.; Xu, Haixuan

    2015-08-04

    The recombination radius of a Frenkel pair is a fundamental parameter for the object kinetic Monte Carlo (OKMC) and mean field rate theory (RT) methods that are used to investigate irradiation damage accumulation in neutron irradiated nuclear materials. The recombination radius in bcc Fe has been studied both experimentally and numerically, however there is no general consensus about its value. The detailed atomistic processes of recombination also remain uncertain. Values from 1:0a? to 3:3a? have been employed as a recombination radius in previous studies using OKMC and RT. The recombination process of a Frenkel pair is investigated at the atomic level using the self-evolved atomistic kinetic Monte Carlo (SEAKMC) method in this paper. SEAKMC calculations reveal that a self-interstitial atom recombines with a vacancy in a spontaneous reaction from several nearby sites following characteristic pathways. The recombination radius of a Frenkel pair is estimated to be 2.26a? by taking the average of the recombination distances from 80 simulation cases. This value agrees well with the experimental estimate. In addition, we apply these procedures to the capture radius of a self-interstitial atom by a vacancy cluster. The capture radius is found to gradually increase with the size of the vacancy cluster. The fitting curve for the capture radius is obtained as a function of the number of vacancies in the cluster.

  20. Once-Daily Radiation Therapy for Inflammatory Breast Cancer

    SciTech Connect

    Brown, Lindsay; Harmsen, William; Blanchard, Miran; Goetz, Matthew; Jakub, James; Mutter, Robert; Petersen, Ivy; Rooney, Jessica; Stauder, Michael; Yan, Elizabeth; Laack, Nadia

    2014-08-01

    Purpose: Inflammatory breast cancer (IBC) is a rare and aggressive breast cancer variant treated with multimodality therapy. A variety of approaches intended to escalate the intensity and efficacy of radiation therapy have been reported, including twice-daily radiation therapy, dose escalation, and aggressive use of bolus. Herein, we examine our outcomes for patients treated with once-daily radiation therapy with aggressive bolus utilization, focusing on treatment technique. Methods and Materials: A retrospective review of patients with nonmetastatic IBC treated from January 1, 2000, through December 31, 2010, was performed. Locoregional control (LRC), disease-free survival (DFS), overall survival (OS) and predictors thereof were assessed. Results: Fifty-two women with IBC were identified, 49 (94%) of whom were treated with neoadjuvant chemotherapy. All underwent mastectomy followed by adjuvant radiation therapy. Radiation was delivered in once-daily fractions of 1.8 to 2.25 Gy (median, 2 Gy). Patients were typically treated with daily 1-cm bolus throughout treatment, and 33 (63%) received a subsequent boost to the mastectomy scar. Five-year Kaplan Meier survival estimates for LRC, DFS, and OS were 81%, 56%, and 64%, respectively. Locoregional recurrence was associated with poorer OS (P<.001; hazard ratio [HR], 4.1). Extracapsular extension was associated with worse LRC (P=.02), DFS (P=.007), and OS (P=.002). Age greater than 50 years was associated with better DFS (P=.03). Pathologic complete response was associated with a trend toward improved LRC (P=.06). Conclusions: Once-daily radiation therapy with aggressive use of bolus for IBC results in outcomes consistent with previous reports using various intensified radiation therapy regimens. LRC remains a challenge despite modern systemic therapy. Extracapsular extension, age ≤50 years, and lack of complete response to chemotherapy appear to be associated with worse outcomes. Novel strategies are needed in IBC

  1. Targeted radionuclide therapy

    SciTech Connect

    Williams, Lawrence E.; DeNardo, Gerald L.; Meredith, Ruby F.

    2008-07-15

    Targeted radionuclide therapy (TRT) seeks molecular and functional targets within patient tumor sites. A number of agents have been constructed and labeled with beta, alpha, and Auger emitters. Radionuclide carriers spanning a broad range of sizes; e.g., antibodies, liposomes, and constructs such as nanoparticles have been used in these studies. Uptake, in percent-injected dose per gram of malignant tissue, is used to evaluate the specificity of the targeting vehicle. Lymphoma (B-cell) has been the primary clinical application. Extension to solid tumors will require raising the macroscopic absorbed dose by several-fold over values found in present technology. Methods that may effect such changes include multistep targeting, simultaneous chemotherapy, and external sequestration of the agent. Toxicity has primarily involved red marrow so that marrow replacement can also be used to enhance future TRT treatments. Correlation of toxicities and treatment efficiency has been limited by relatively poor absorbed dose estimates partly because of using standard (phantom) organ sizes. These associations will be improved in the future by obtaining patient-specific organ size and activity data with hybrid SPECT/CT and PET/CT scanners.

  2. A Prospective Longitudinal Clinical Trial Evaluating Quality of Life After Breast-Conserving Surgery and High-Dose-Rate Interstitial Brachytherapy for Early-Stage Breast Cancer

    SciTech Connect

    Garsa, Adam A.; Ferraro, Daniel J.; DeWees, Todd A.; Deshields, Teresa L.; Margenthaler, Julie A.; Cyr, Amy E.; Naughton, Michael; Aft, Rebecca; Gillanders, William E.; Eberlein, Timothy; Matesa, Melissa A.; Ochoa, Laura L.; Zoberi, Imran

    2013-12-01

    Purpose: To prospectively examine quality of life (QOL) of patients with early stage breast cancer treated with accelerated partial breast irradiation (APBI) using high-dose-rate (HDR) interstitial brachytherapy. Methods and Materials: Between March 2004 and December 2008, 151 patients with early stage breast cancer were enrolled in a phase 2 prospective clinical trial. Eligible patients included those with Tis-T2 tumors measuring ?3 cm excised with negative surgical margins and with no nodal involvement. Patients received 3.4 Gy twice daily to a total dose of 34 Gy. QOL was measured using European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30, version 3.0, and QLQ-BR23 questionnaires. The QLQ-C30 and QLQ-BR23 questionnaires were evaluated during pretreatment and then at 6 to 8 weeks, 3 to 4 months, 6 to 8 months, and 1 and 2 years after treatment. Results: The median follow-up was 55 months. Breast symptom scores remained stable in the months after treatment, and they significantly improved 6 to 8 months after treatment. Scores for emotional functioning, social functioning, and future perspective showed significant improvement 2 years after treatment. Symptomatic fat necrosis was associated with several changes in QOL, including increased pain, breast symptoms, systemic treatment side effects, dyspnea, and fatigue, as well as decreased role functioning, emotional functioning, and social functioning. Conclusions: HDR multicatheter interstitial brachytherapy was well tolerated, with no significant detrimental effect on measured QOL scales/items through 2 years of follow-up. Compared to pretreatment scores, there was improvement in breast symptoms, emotional functioning, social functioning, and future perspective 2 years after treatment.

  3. AUDIT REPORT

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    heart imaging, cancer therapy, smoke and explosive detectors, and oil exploration. ... create actinium-225 and bismuth-213, two extremely rare isotopes used in cancer research. ...

  4. Report to Congress on abnormal occurrences, October--December 1988

    SciTech Connect

    Not Available

    1989-04-01

    Section 208 of the Energy Reorganization Act of 1974 identifies an abnormal occurrence as an unscheduled incident or event which the Nuclear Regulatory Commission determines to be significant from the standpoint of public health or safety and requires a quarterly report of such events to be made to Congress. This report covers the period from October 1 to December 31, 1988. For this reporting period, there were no abnormal occurrences at nuclear power plants licensed to operate. There was one abnormal occurrence under other NRC-issued licenses involving a medical therapy misadministration. Three other abnormal occurrences were reported by Agreement States. The State of New York reported an event involving multiple medical therapy misadministrations. The State of Maryland reported two events, both occurring at the same hospital. One involved a single medical therapy misadministration and the second involved multiple medical therapy misadministrations. The report also contains information updating some previously reported abnormal occurrences. 3 refs.

  5. Image-Guided Radiotherapy for Cervix Cancer: High-Tech External Beam Therapy Versus High-Tech Brachytherapy

    SciTech Connect

    Georg, Dietmar Kirisits, Christian; Hillbrand, Martin; Dimopoulos, Johannes; Poetter, Richard

    2008-07-15

    Purpose: Many studies comparing external-beam therapy (EBT) and brachytherapy (BT) are biased because advanced EBT is compared with conventional BT. This study compares high-tech EBT against high-tech BT. Methods and Materials: Nine patients were selected with locally advanced cervix cancer, representing typical clinical situations according to initial tumor extension and response after EBT. Patients were treated either with intracavitary, combined interstitial/intracavitary, or complex interstitial BT. Gross tumor volume, high-risk clinical target volume (CTV), intermediate-risk CTV, bladder, rectum, and sigmoid were delineated. Magnetic resonance-guided BT planning was manually optimized with respect to organ dose limits. Margins (3 and 5 mm) were added to BT CTVs to construct planning target volumes (PTVs) for EBT. Inversely planned EBT with photons (IMRT) and protons (IMPT) was challenged to deliver the highest possible doses to PTVs while respecting D{sub 1cc} and D{sub 2cc} limits from BT, assuming the same fractionation (4 x 7 Gy). The D90 for target structures and normal tissue volumes receiving fractionated doses between 3 and 7 Gy were compared. Results: High-risk CTV doses depended on the clinical situation and radiation quality. If IMRT was limited to D{sub 2cc} and D{sub 1cc} from BT, the D90 for high-risk PTV and intermediate-risk PTV was mostly lower. Volumes receiving 60 Gy (in equivalent dose in 20 Gy fractions) were approximately twice as large for IMRT compared with BT. For IMPT, this volume ratio was lower. Planning target volume doses of IMPT plans with 3-mm margins were comparable to those with BT. Gross tumor volume doses were mostly lower for both IMRT and IMPT. Conclusion: For benchmarking high-tech EBT, high-tech BT techniques have to be used. For cervix cancer boost treatments, both IMRT and IMPT seem to be inferior to advanced BT.

  6. Validation of mathematical models for the prediction of organs-at-risk dosimetric metrics in high-dose-rate gynecologic interstitial brachytherapy

    SciTech Connect

    Damato, Antonio L.; Viswanathan, Akila N.; Cormack, Robert A.

    2013-10-15

    Purpose: Given the complicated nature of an interstitial gynecologic brachytherapy treatment plan, the use of a quantitative tool to evaluate the quality of the achieved metrics compared to clinical practice would be advantageous. For this purpose, predictive mathematical models to predict the D{sub 2cc} of rectum and bladder in interstitial gynecologic brachytherapy are discussed and validated.Methods: Previous plans were used to establish the relationship between D2cc and the overlapping volume of the organ at risk with the targeted area (C0) or a 1-cm expansion of the target area (C1). Three mathematical models were evaluated: D{sub 2cc}=α*C{sub 1}+β (LIN); D{sub 2cc}=α– exp(–β*C{sub 0}) (EXP); and a mixed approach (MIX), where both C{sub 0} and C{sub 1} were inputs of the model. The parameters of the models were optimized on a training set of patient data, and the predictive error of each model (predicted D{sub 2cc}− real D{sub 2cc}) was calculated on a validation set of patient data. The data of 20 patients were used to perform a K-fold cross validation analysis, with K = 2, 4, 6, 8, 10, and 20.Results: MIX was associated with the smallest mean prediction error <6.4% for an 18-patient training set; LIN had an error <8.5%; EXP had an error <8.3%. Best case scenario analysis shows that an error ≤5% can be achieved for a ten-patient training set with MIX, an error ≤7.4% for LIN, and an error ≤6.9% for EXP. The error decreases with the increase in training set size, with the most marked decrease observed for MIX.Conclusions: The MIX model can predict the D{sub 2cc} of the organs at risk with an error lower than 5% with a training set of ten patients or greater. The model can be used in the development of quality assurance tools to identify treatment plans with suboptimal sparing of the organs at risk. It can also be used to improve preplanning and in the development of real-time intraoperative planning tools.

  7. Electrical signature analysis to quantify human and animal performance on fitness and therapy equipment such as a treadmill

    SciTech Connect

    Cox, Daryl F.; Hochanadel, Charles D.; Haynes, Howard D.

    2010-05-18

    The invention is a human and animal performance data acquisition, analysis, and diagnostic system for fitness and therapy devices having an interface box removably disposed on incoming power wiring to a fitness and therapy device, at least one current transducer removably disposed on said interface box for sensing current signals to said fitness and therapy device, and a means for analyzing, displaying, and reporting said current signals to determine human and animal performance on said device using measurable parameters.

  8. Chemoradiotherapeutic wrinkled mesoporous silica nanoparticles for use in cancer therapy

    SciTech Connect

    Munaweera, Imalka; Balkus, Kenneth J. Jr. E-mail: Anthony.DiPasqua@unthsc.edu; Koneru, Bhuvaneswari; Shi, Yi; Di Pasqua, Anthony J. E-mail: Anthony.DiPasqua@unthsc.edu

    2014-11-01

    Over the last decade, the development and application of nanotechnology in cancer detection, diagnosis, and therapy have been widely reported. Engineering of vehicles for the simultaneous delivery of chemo- and radiotherapeutics increases the effectiveness of the therapy and reduces the dosage of each individual drug required to produce an observable therapeutic response. We here developed a novel chemoradiotherapeutic 1,2-dioleoyl-sn-glycero-3-phosphocholine lipid coated/uncoated platinum drug loaded, holmium-containing, wrinkled mesoporous silica nanoparticle. The materials were characterized with TEM, FTIR, {sup 1}H NMR, energy dispersive x-ray, inductively coupled plasma-mass spectrometry, and zeta potential measurements. In vitro platinum drug release from both lipid coated and uncoated chemoradiotherapeutic wrinkled mesoporous silica are reported. Various kinetic models were used to analyze the release kinetics. The radioactivity of the chemoradiotherapeutic nanocarriers was measured after neutron-activation.

  9. Annual Reports - SRSCRO

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    reports Annual Reports Annual Report 2015 Annual Report 2014 Annual Report 2013 Annual Report 2012 Annual Report 2011 Annual Report 2010 Annual Report 2009 Annual Report 2008...

  10. A Dosimetric Comparison of Accelerated Partial Breast Irradiation Techniques: Multicatheter Interstitial Brachytherapy, Three-Dimensional Conformal Radiotherapy, and Supine Versus Prone Helical Tomotherapy

    SciTech Connect

    Patel, Rakesh R. . E-mail: patel@humonc.wisc.edu; Becker, Stewart J.; Das, Rupak K.; Mackie, Thomas R.

    2007-07-01

    Purpose: To compare dosimetrically four different techniques of accelerated partial breast irradiation (APBI) in the same patient. Methods and Materials: Thirteen post-lumpectomy interstitial brachytherapy (IB) patients underwent imaging with preimplant computed tomography (CT) in the prone and supine position. These CT scans were then used to generate three-dimensional conformal radiotherapy (3D-CRT) and prone and supine helical tomotherapy (PT and ST, respectively) APBI plans and compared with the treated IB plans. Dose-volume histogram analysis and the mean dose (NTD{sub mean}) values were compared. Results: Planning target volume coverage was excellent for all methods. Statistical significance was considered to be a p value <0.05. The mean V100 was significantly lower for IB (12% vs. 15% for PT, 18% for ST, and 26% for 3D-CRT). A greater significant differential was seen when comparing V50 with mean values of 24%, 43%, 47%, and 52% for IB, PT, ST, and 3D-CRT, respectively. The IB and PT were similar and delivered an average lung NTD{sub mean} dose of 1.3 Gy{sub 3} and 1.2 Gy{sub 3}, respectively. Both of these methods were statistically significantly lower than the supine external beam techniques. Overall, all four methods yielded similar low doses to the heart. Conclusions: The use of IB and PT resulted in greater normal tissue sparing (especially ipsilateral breast and lung) than the use of supine external beam techniques of 3D-CRT or ST. However, the choice of APBI technique must be tailored to the patient's anatomy, lumpectomy cavity location, and overall treatment goals.

  11. Find Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Classified reports - contact the SI-RMS Technical Report Collection for an appointment: ... Office 94 Cities of Gold Road Santa Fe, NM 87506 Where can I find Classified Reports? ...

  12. Monthly Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Environmental Management Monthly Reports - FY 2015 The Department of Energy Nevada Field Office Environmental Management Program creates monthly reports for the NSSAB. These ...

  13. Reporting Requirements

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Reporting Requirements Reporting Requirements Contacts Director Albert Migliori Deputy Franz Freibert 505 667-6879 Email Professional Staff Assistant Susan Ramsay 505 665 0858...

  14. Monthly Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Environmental Management Monthly Reports - FY 2014 The Department of Energy Nevada Field Office Environmental Management Program creates monthly reports for the NSSAB. These...

  15. Monthly Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Environmental Management Monthly Reports - FY 2015 The Department of Energy Nevada Field Office Environmental Management Program creates monthly reports for the NSSAB. These...

  16. Monthly Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Environmental Management Monthly Reports - FY 2013 The Department of Energy Nevada Field Office Environmental Management Program creates monthly reports for the NSSAB. These...

  17. Monthly Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Environmental Management Monthly Reports - FY 2012 The Department of Energy Nevada Field Office Environmental Management Program creates monthly reports for the NSSAB. These...

  18. Proton beam therapy control system

    DOEpatents

    Baumann, Michael A; Beloussov, Alexandre V; Bakir, Julide; Armon, Deganit; Olsen, Howard B; Salem, Dana

    2013-06-25

    A tiered communications architecture for managing network traffic in a distributed system. Communication between client or control computers and a plurality of hardware devices is administered by agent and monitor devices whose activities are coordinated to reduce the number of open channels or sockets. The communications architecture also improves the transparency and scalability of the distributed system by reducing network mapping dependence. The architecture is desirably implemented in a proton beam therapy system to provide flexible security policies which improve patent safety and facilitate system maintenance and development.

  19. Proton beam therapy control system

    DOEpatents

    Baumann, Michael A.; Beloussov, Alexandre V.; Bakir, Julide; Armon, Deganit; Olsen, Howard B.; Salem, Dana

    2008-07-08

    A tiered communications architecture for managing network traffic in a distributed system. Communication between client or control computers and a plurality of hardware devices is administered by agent and monitor devices whose activities are coordinated to reduce the number of open channels or sockets. The communications architecture also improves the transparency and scalability of the distributed system by reducing network mapping dependence. The architecture is desirably implemented in a proton beam therapy system to provide flexible security policies which improve patent safety and facilitate system maintenance and development.

  20. Proton beam therapy control system

    DOEpatents

    Baumann, Michael A; Beloussov, Alexandre V; Bakir, Julide; Armon, Deganit; Olsen, Howard B; Salem, Dana

    2013-12-03

    A tiered communications architecture for managing network traffic in a distributed system. Communication between client or control computers and a plurality of hardware devices is administered by agent and monitor devices whose activities are coordinated to reduce the number of open channels or sockets. The communications architecture also improves the transparency and scalability of the distributed system by reducing network mapping dependence. The architecture is desirably implemented in a proton beam therapy system to provide flexible security policies which improve patent safety and facilitate system maintenance and development.

  1. Proton beam therapy control system

    DOEpatents

    Baumann, Michael A.; Beloussov, Alexandre V.; Bakir, Julide; Armon, Deganit; Olsen, Howard B.; Salem, Dana

    2010-09-21

    A tiered communications architecture for managing network traffic in a distributed system. Communication between client or control computers and a plurality of hardware devices is administered by agent and monitor devices whose activities are coordinated to reduce the number of open channels or sockets. The communications architecture also improves the transparency and scalability of the distributed system by reducing network mapping dependence. The architecture is desirably implemented in a proton beam therapy system to provide flexible security policies which improve patent safety and facilitate system maintenance and development.

  2. Compact accelerator for medical therapy

    DOEpatents

    Caporaso, George J.; Chen, Yu-Jiuan; Hawkins, Steven A.; Sampayan, Stephen E.; Paul, Arthur C.

    2010-05-04

    A compact accelerator system having an integrated particle generator-linear accelerator with a compact, small-scale construction capable of producing an energetic (.about.70-250 MeV) proton beam or other nuclei and transporting the beam direction to a medical therapy patient without the need for bending magnets or other hardware often required for remote beam transport. The integrated particle generator-accelerator is actuable as a unitary body on a support structure to enable scanning of a particle beam by direction actuation of the particle generator-accelerator.

  3. Method for microbeam radiation therapy

    DOEpatents

    Slatkin, Daniel N.; Dilmanian, F. Avraham; Spanne, Per O.

    1994-01-01

    A method of performing radiation therapy on a patient, involving exposing a target, usually a tumor, to a therapeutic dose of high energy electromagnetic radiation, preferably X-ray radiation, in the form of at least two non-overlapping microbeams of radiation, each microbeam having a width of less than about 1 millimeter. Target tissue exposed to the microbeams receives a radiation dose during the exposure that exceeds the maximum dose that such tissue can survive. Non-target tissue between the microbeams receives a dose of radiation below the threshold amount of radiation that can be survived by the tissue, and thereby permits the non-target tissue to regenerate. The microbeams may be directed at the target from one direction, or from more than one direction in which case the microbeams overlap within the target tissue enhancing the lethal effect of the irradiation while sparing the surrounding healthy tissue.

  4. Method for microbeam radiation therapy

    DOEpatents

    Slatkin, D.N.; Dilmanian, F.A.; Spanne, P.O.

    1994-08-16

    A method is disclosed of performing radiation therapy on a patient, involving exposing a target, usually a tumor, to a therapeutic dose of high energy electromagnetic radiation, preferably X-ray radiation. The dose is in the form of at least two non-overlapping microbeams of radiation, each microbeam having a width of less than about 1 millimeter. Target tissue exposed to the microbeams receives a radiation dose during the exposure that exceeds the maximum dose that such tissue can survive. Non-target tissue between the microbeams receives a dose of radiation below the threshold amount of radiation that can be survived by the tissue, and thereby permits the non-target tissue to regenerate. The microbeams may be directed at the target from one direction, or from more than one direction in which case the microbeams overlap within the target tissue enhancing the lethal effect of the irradiation while sparing the surrounding healthy tissue. No Drawings

  5. Workshop on neutron capture therapy

    SciTech Connect

    Fairchild, R.G.; Bond, V.P.

    1986-01-01

    Potentially optimal conditions for Neutron Capture Therapy (NCT) may soon be in hand due to the anticipated development of band-pass filtered beams relatively free of fast neutron contaminations, and of broadly applicable biomolecules for boron transport such as porphyrins and monoclonal antibodies. Consequently, a number of groups in the US are now devoting their efforts to exploring NCT for clinical application. The purpose of this Workshop was to bring these groups together to exchange views on significant problems of mutual interest, and to assure a unified and effective approach to the solutions. Several areas of preclinical investigation were deemed to be necessary before it would be possible to initiate clinical studies. As neither the monomer nor the dimer of sulfhydryl boron hydride is unequivocally preferable at this time, studies on both compounds should be continued until one is proven superior.

  6. Prototype demonstration of radiation therapy planning code system

    SciTech Connect

    Little, R.C.; Adams, K.J.; Estes, G.P.; Hughes, L.S. III; Waters, L.S.

    1996-09-01

    This is the final report of a one-year, Laboratory-Directed Research and Development project at the Los Alamos National Laboratory (LANL). Radiation therapy planning is the process by which a radiation oncologist plans a treatment protocol for a patient preparing to undergo radiation therapy. The objective is to develop a protocol that delivers sufficient radiation dose to the entire tumor volume, while minimizing dose to healthy tissue. Radiation therapy planning, as currently practiced in the field, suffers from inaccuracies made in modeling patient anatomy and radiation transport. This project investigated the ability to automatically model patient-specific, three-dimensional (3-D) geometries in advanced Los Alamos radiation transport codes (such as MCNP), and to efficiently generate accurate radiation dose profiles in these geometries via sophisticated physics modeling. Modem scientific visualization techniques were utilized. The long-term goal is that such a system could be used by a non-expert in a distributed computing environment to help plan the treatment protocol for any candidate radiation source. The improved accuracy offered by such a system promises increased efficacy and reduced costs for this important aspect of health care.

  7. SANDIA REPORT

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... 32 Figure 16. DowntimesSuspension Times SQL Query ......including installation details, customer contact information, and incident report history. ...

  8. Validation of a novel robot-assisted 3DUS system for real-time planning and guidance of breast interstitial HDR brachytherapy

    SciTech Connect

    Poulin, Eric; Beaulieu, Luc; Gardi, Lori; Barker, Kevin; Montreuil, Jacques; Fenster, Aaron

    2015-12-15

    Purpose: In current clinical practice, there is no integrated 3D ultrasound (3DUS) guidance system clinically available for breast brachytherapy. In this study, the authors present a novel robot-assisted 3DUS system for real-time planning and guidance of breast interstitial high dose rate (HDR) brachytherapy treatment. Methods: For this work, a new computer controlled robotic 3DUS system was built to perform a hybrid motion scan, which is a combination of a 6 cm linear translation with a 30° rotation at both ends. The new 3DUS scanner was designed to fit on a modified Kuske assembly, keeping the current template grid configuration but modifying the frame to allow the mounting of the 3DUS system at several positions. A finer grid was also tested. A user interface was developed to perform image reconstruction, semiautomatic segmentation of the surgical bed as well as catheter reconstruction and tracking. A 3D string phantom was used to validate the geometric accuracy of the reconstruction. The volumetric accuracy of the system was validated with phantoms using magnetic resonance imaging (MRI) and computed tomography (CT) images. In order to accurately determine whether 3DUS can effectively replace CT for treatment planning, the authors have compared the 3DUS catheter reconstruction to the one obtained from CT images. In addition, in agarose-based phantoms, an end-to-end procedure was performed by executing six independent complete procedures with both 14 and 16 catheters, and for both standard and finer Kuske grids. Finally, in phantoms, five end-to-end procedures were performed with the final CT planning for the validation of 3DUS preplanning. Results: The 3DUS acquisition time is approximately 10 s. A paired Student t-test showed that there was no statistical significant difference between known and measured values of string separations in each direction. Both MRI and CT volume measurements were not statistically different from 3DUS volume (Student t-test: p > 0

  9. Implementation of Remote 3-Dimensional Image Guided Radiation Therapy Quality Assurance for Radiation Therapy Oncology Group Clinical Trials

    SciTech Connect

    Cui Yunfeng; Galvin, James M.; Radiation Therapy Oncology Group, American College of Radiology, Philadelphia, Pennsylvania ; Parker, William; Breen, Stephen; Yin Fangfang; Cai Jing; Papiez, Lech S.; Li, X. Allen; Bednarz, Greg; Chen Wenzhou; Xiao Ying

    2013-01-01

    Purpose: To report the process and initial experience of remote credentialing of three-dimensional (3D) image guided radiation therapy (IGRT) as part of the quality assurance (QA) of submitted data for Radiation Therapy Oncology Group (RTOG) clinical trials; and to identify major issues resulting from this process and analyze the review results on patient positioning shifts. Methods and Materials: Image guided radiation therapy datasets including in-room positioning CT scans and daily shifts applied were submitted through the Image Guided Therapy QA Center from institutions for the IGRT credentialing process, as required by various RTOG trials. A centralized virtual environment is established at the RTOG Core Laboratory, containing analysis tools and database infrastructure for remote review by the Physics Principal Investigators of each protocol. The appropriateness of IGRT technique and volumetric image registration accuracy were evaluated. Registration accuracy was verified by repeat registration with a third-party registration software system. With the accumulated review results, registration differences between those obtained by the Physics Principal Investigators and from the institutions were analyzed for different imaging sites, shift directions, and imaging modalities. Results: The remote review process was successfully carried out for 87 3D cases (out of 137 total cases, including 2-dimensional and 3D) during 2010. Frequent errors in submitted IGRT data and challenges in the review of image registration for some special cases were identified. Workarounds for these issues were developed. The average differences of registration results between reviewers and institutions ranged between 2 mm and 3 mm. Large discrepancies in the superior-inferior direction were found for megavoltage CT cases, owing to low spatial resolution in this direction for most megavoltage CT cases. Conclusion: This first experience indicated that remote review for 3D IGRT as part of QA

  10. Rational design and adaptive management of combination therapies...

    Office of Scientific and Technical Information (OSTI)

    therapies for Hepatitis C virus infection Prev Next Title: Rational design and adaptive management of combination therapies for Hepatitis C virus infection Recent ...

  11. Rational Design and Adaptive Management of Combination Therapies...

    Office of Scientific and Technical Information (OSTI)

    of Combination Therapies for Hepatitis C Virus Infection CrossMark click for updates n ... Design and Adaptive Management of Combination Therapies for Hepatitis C Virus Infection. ...

  12. Shape memory polymer foams for endovascular therapies (Patent...

    Office of Scientific and Technical Information (OSTI)

    Patent: Shape memory polymer foams for endovascular therapies Citation Details In-Document Search Title: Shape memory polymer foams for endovascular therapies A system for ...

  13. Shape memory polymer foams for endovascular therapies (Patent...

    Office of Scientific and Technical Information (OSTI)

    Shape memory polymer foams for endovascular therapies Title: Shape memory polymer foams for endovascular therapies A system for occluding a physical anomaly. One embodiment ...

  14. SPECIAL REPORT

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Allegations Related to the Energy Information Administration's Reporting Process DOE/IG-0940 June 2015 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 June 10, 2015 MEMORANDUM FOR THE SECRETARY FROM: Gregory H. Friedman Inspector General SUBJECT: INFORMATION: Special Report: "Allegations Related to the Energy Information Administration's Reporting Process" BACKGROUND The Energy Information Administration

  15. ASSESSMENT REPORT

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Inspector General SUBJECT: INFORMATION: Assessment Report on "Audit Coverage of Cost Allowability for Babcock & Wilcox Technical Services Pantex LLC During Fiscal Year 2013 ...

  16. FINAL REPORT

    Office of Scientific and Technical Information (OSTI)

    FINAL REPORT Analytical and Elemental Analysis of Air and Soil Samples Facility and Public ... Information 4 Background 5 Stormwater Pollution 5 Erosion and Sediment Control Workshop ...

  17. AUDIT REPORT

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Inspector General SUBJECT: INFORMATION: Audit Report on the "Management and Oversight of ... Shortly after the audit began, Richland Operations Office officials stated that they had ...

  18. SPECIAL REPORT

    Energy.gov [DOE] (indexed site)

    Washington, DC 20585 September 3, 2015 MEMORANDUM FOR THE SECRETARY FROM: Gregory H. Friedman Inspector General SUBJECT: INFORMATION: Special Report: "The Department of Energy's...

  19. AUDIT REPORT

    Energy.gov [DOE] (indexed site)

    Activities at Y-12 include retrieving and storing nuclear materials, helping fuel the Nation's ... In June 2004, the Office of Inspector General's report on Management of the ...

  20. Report: Communications

    Office of Environmental Management (EM)

    Board (EMAB) issued a report to the Assistant Secretary ... appraisals beginning in FY 2008. EMAB applauds the ... performance; however, the Board stresses that such an ...

  1. Decision Regret in Men Undergoing Dose-Escalated Radiation Therapy for Prostate Cancer

    SciTech Connect

    Steer, Anna N.; Aherne, Noel J.; Gorzynska, Karen; Hoffman, Matthew; Last, Andrew; Hill, Jacques; Shakespeare, Thomas P.; Rural Clinical School Faculty of Medicine, University of New South Wales, Coffs Harbour

    2013-07-15

    Purpose: Decision regret (DR) is a negative emotion associated with medical treatment decisions, and it is an important patient-centered outcome after therapy for localized prostate cancer. DR has been found to occur in up to 53% of patients treated for localized prostate cancer, and it may vary depending on treatment modality. DR after modern dose-escalated radiation therapy (DE-RT) has not been investigated previously, to our knowledge. Our primary aim was to evaluate DR in a cohort of patients treated with DE-RT. Methods and Materials: We surveyed 257 consecutive patients with localized prostate cancer who had previously received DE-RT, by means of a validated questionnaire. Results: There were 220 responses (85.6% response rate). Image-guided intensity modulated radiation therapy was given in 85.0% of patients and 3-dimensional conformal radiation therapy in 15.0%. Doses received included 73.8 Gy (34.5% patients), 74 Gy (53.6%), and 76 Gy (10.9%). Neoadjuvant androgen deprivation (AD) was given in 51.8% of patients and both neoadjuvant and adjuvant AD in 34.5%. The median follow-up time was 23 months (range, 12-67 months). In all, 3.8% of patients expressed DR for their choice of treatment. When asked whether they would choose DE-RT or AD again, only 0.5% probably or definitely would not choose DE-RT again, compared with 8.4% for AD (P<.01). Conclusion: Few patients treated with modern DE-RT express DR, with regret appearing to be lower than in previously published reports of patients treated with radical prostatectomy or older radiation therapy techniques. Patients experienced more regret with the AD component of treatment than with the radiation therapy component, with implications for informed consent. Further research should investigate regret associated with individual components of modern therapy, including AD, radiation therapy and surgery.

  2. Nonclinical safety strategies for stem cell therapies

    SciTech Connect

    Sharpe, Michaela E.; Morton, Daniel; Rossi, Annamaria

    2012-08-01

    Recent breakthroughs in stem cell biology, especially the development of the induced pluripotent stem cell techniques, have generated tremendous enthusiasm and efforts to explore the therapeutic potential of stem cells in regenerative medicine. Stem cell therapies are being considered for the treatment of degenerative diseases, inflammatory conditions, cancer and repair of damaged tissue. The safety of a stem cell therapy depends on many factors including the type of cell therapy, the differentiation status and proliferation capacity of the cells, the route of administration, the intended clinical location, long term survival of the product and/or engraftment, the need for repeated administration, the disease to be treated and the age of the population. Understanding the product profile of the intended therapy is crucial to the development of the nonclinical safety study design.

  3. EUD-based biological optimization for carbon ion therapy

    SciTech Connect

    Brüningk, Sarah C. Kamp, Florian; Wilkens, Jan J.

    2015-11-15

    Purpose: Treatment planning for carbon ion therapy requires an accurate modeling of the biological response of each tissue to estimate the clinical outcome of a treatment. The relative biological effectiveness (RBE) accounts for this biological response on a cellular level but does not refer to the actual impact on the organ as a whole. For photon therapy, the concept of equivalent uniform dose (EUD) represents a simple model to take the organ response into account, yet so far no formulation of EUD has been reported that is suitable to carbon ion therapy. The authors introduce the concept of an equivalent uniform effect (EUE) that is directly applicable to both ion and photon therapies and exemplarily implemented it as a basis for biological treatment plan optimization for carbon ion therapy. Methods: In addition to a classical EUD concept, which calculates a generalized mean over the RBE-weighted dose distribution, the authors propose the EUE to simplify the optimization process of carbon ion therapy plans. The EUE is defined as the biologically equivalent uniform effect that yields the same probability of injury as the inhomogeneous effect distribution in an organ. Its mathematical formulation is based on the generalized mean effect using an effect-volume parameter to account for different organ architectures and is thus independent of a reference radiation. For both EUD concepts, quadratic and logistic objective functions are implemented into a research treatment planning system. A flexible implementation allows choosing for each structure between biological effect constraints per voxel and EUD constraints per structure. Exemplary treatment plans are calculated for a head-and-neck patient for multiple combinations of objective functions and optimization parameters. Results: Treatment plans optimized using an EUE-based objective function were comparable to those optimized with an RBE-weighted EUD-based approach. In agreement with previous results from photon

  4. Novel targeted therapy for stomach cancer

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Novel targeted therapy for stomach cancer Novel targeted therapy for stomach cancer This finding has the potential to save thousand of lives a year by delivering a more effective, targeted treatment for cancer patients. October 29, 2015 New research at Los Alamos National Laboratory and the Wellcome Trust Sanger Institute shows a molecular fingerprint in stomach cancer that shows it can be treated with platinum drugs and/or molecular inhibitors known as PARP (poly ADP ribose polymerase). New

  5. Special Report

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Special Report 1501 MACY DRIVE ROSWELL, GA 30076 PH +1 770 642-7745 FX +1 770 643-2954 Impact of DOE Inventory Sales on the Nuclear Fuel Markets January | 2015 A PUBLICATION OF UXC.COM PREPARED FOR Cameco Corporation - NOTICE - The Ux Consulting Company, LLC ("UxC") shall have title to, ownership of, and all proprietary rights in this Report. Under United States federal copyright law (17 USC 101 et seq.) it is illegal to reproduce this Report by any means without written permission

  6. AUDIT REPORT

    Office of Environmental Management (EM)

    Enriched Uranium Operations at the Y-12 National Security Complex DOE-OIG-16-13 July 2016 ... INFORMATION: Audit Report on "Enriched Uranium Operations at the Y-12 National Security ...

  7. Final Report

    SciTech Connect

    Biros, George

    2014-08-18

    This the final report for the project "Large-Scale Optimization for Bayesian Inference in Complex Systems," for the work in the group of the co-PI George Biros.

  8. Final Report

    SciTech Connect

    DeTar, Carleton

    2012-12-10

    This document constitutes the Final Report for award DE-FC02-06ER41446 as required by the Office of Science. It summarizes accomplishments and provides copies of scientific publications with significant contribution from this award.

  9. AUDIT REPORT

    Office of Environmental Management (EM)

    Treatment of Salt Waste at the Savannah River Site OAS-L-15-09 August 2015 U.S. Department ... Audit Report: "Treatment of Salt Waste at the Savannah River Site" BACKGROUND The ...

  10. Workshop Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    we do not know why. Complete Executive Summary (pdf) Read entire Final Report (pdf) LA-UR 10-02959 Research Needs for Material Mixing at Extremes (pdf) Image of the Cover of...

  11. SAND REPORT

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    SAND REPORT SAND2001 -2950 Unlimited Release Printed September 2001 Useful Equations fol Induced Voltage I n s L en ^trucC- ~ dissemination unlimited. mg.,jandia National laboratories i / . Issued by Sandia National Laboratories, operated for the United States Department of Energy by Sandia Corporation. NOTICE: This report was prepared as an account of work sponsored by an agency of the United States Government. Neither the United States Government, nor any agency thereof, nor any of their

  12. SANDIA REPORT

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    SANDIA REPORT SAND 2011-3958 Unlimited Release Printed June 2011 Site Environmental Report for 2010 Sandia National Laboratories, California B.L. Larsen Prepared by Sandia National Laboratories Livermore, California 94550 Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under Contract DE-AC04-94AL85000.

  13. Reporting Requirements

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Reporting Requirements Reporting Requirements Contacts Director Albert Migliori Deputy Franz Freibert 505 667-6879 Email Professional Staff Assistant Susan Ramsay 505 665 0858 Email The Fellow will be required to participate in the Actinide Science lecture series by both attending lectures and presenting a scientific lecture on actinide science in this series. Submission of a viewgraph and brief write-up of the project. Provide metrics information as requested. Submission of an overview article

  14. SPECIAL REPORT

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    SPECIAL REPORT Enforcement Activities Conducted by the Federal Energy Regulatory Commission DOE/IG-0947 September 2015 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 September 29, 2015 MEMORANDUM FOR THE CHAIRMAN, FEDERAL ENERGY REGULATORY COMMISSION FROM: Gregory H. Friedman Inspector General SUBJECT: INFORMATION: Special Report: "Enforcement Activities Conducted by the Federal Energy Regulatory

  15. SUMMARY REPORT

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    SUMMARY REPORT Department of Energy's Implementation of Selected Controls as Defined in the Cybersecurity Act of 2015 DOE-OIG-16-14 August 2016 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 August 4, 2016 MEMORANDUM FOR THE SECRETARY FROM: Rickey R. Hass Acting Inspector General SUBJECT: INFORMATION: Summary Report on the "Department of Energy's Implementation of Selected Controls as Defined in the

  16. A Method for Evaluating Quality Assurance Needs in Radiation Therapy

    SciTech Connect

    Huq, M. Saiful Fraass, Benedick A.; Dunscombe, Peter B.; Gibbons, John P.; Ibbott, Geoffrey S.; Medin, Paul M.; Mundt, Arno; Mutic, Sassa; Palta, Jatinder R.; Thomadsen, Bruce R.; Williamson, Jeffrey F.; Yorke, Ellen D.

    2008-05-01

    The increasing complexity of modern radiation therapy planning and delivery techniques challenges traditional prescriptive quality control and quality assurance programs that ensure safety and reliability of treatment planning and delivery systems under all clinical scenarios. Until now quality management (QM) guidelines published by concerned organizations (e.g., American Association of Physicists in Medicine [AAPM], European Society for Therapeutic Radiology and Oncology [ESTRO], International Atomic Energy Agency [IAEA]) have focused on monitoring functional performance of radiotherapy equipment by measurable parameters, with tolerances set at strict but achievable values. In the modern environment, however, the number and sophistication of possible tests and measurements have increased dramatically. There is a need to prioritize QM activities in a way that will strike a balance between being reasonably achievable and optimally beneficial to patients. A systematic understanding of possible errors over the course of a radiation therapy treatment and the potential clinical impact of each is needed to direct limited resources in such a way to produce maximal benefit to the quality of patient care. Task Group 100 of the AAPM has taken a broad view of these issues and is developing a framework for designing QM activities, and hence allocating resources, based on estimates of clinical outcome, risk assessment, and failure modes. The report will provide guidelines on risk assessment approaches with emphasis on failure mode and effect analysis (FMEA) and an achievable QM program based on risk analysis. Examples of FMEA to intensity-modulated radiation therapy and high-dose-rate brachytherapy are presented. Recommendations on how to apply this new approach to individual clinics and further research and development will also be discussed.

  17. Fast optimization and dose calculation in scanned ion beam therapy

    SciTech Connect

    Hild, S.; Graeff, C.; Trautmann, J.; Kraemer, M.; Zink, K.; Durante, M.; Bert, C.

    2014-07-15

    Purpose: Particle therapy (PT) has advantages over photon irradiation on static tumors. An increased biological effectiveness and active target conformal dose shaping are strong arguments for PT. However, the sensitivity to changes of internal geometry complicates the use of PT for moving organs. In case of interfractionally moving objects adaptive radiotherapy (ART) concepts known from intensity modulated radiotherapy (IMRT) can be adopted for PT treatments. One ART strategy is to optimize a new treatment plan based on daily image data directly before a radiation fraction is delivered [treatment replanning (TRP)]. Optimizing treatment plans for PT using a scanned beam is a time consuming problem especially for particles other than protons where the biological effective dose has to be calculated. For the purpose of TRP, fast optimization and fast dose calculation have been implemented into the GSI in-house treatment planning system (TPS) TRiP98. Methods: This work reports about the outcome of a code analysis that resulted in optimization of the calculation processes as well as implementation of routines supporting parallel execution of the code. To benchmark the new features, the calculation time for therapy treatment planning has been studied. Results: Compared to the original version of the TPS, calculation times for treatment planning (optimization and dose calculation) have been improved by a factor of 10 with code optimization. The parallelization of the TPS resulted in a speedup factor of 12 and 5.5 for the original version and the code optimized version, respectively. Hence the total speedup of the new implementation of the authors' TPS yielded speedup factors up to 55. Conclusions: The improved TPS is capable of completing treatment planning for ion beam therapy of a prostate irradiation considering organs at risk in this has been overseen in the review process. Also see below 6 min.

  18. Report to congress on abnormal occurrences: January--March 1992

    SciTech Connect

    Not Available

    1992-07-01

    Section 208 of the Energy Reorganization Act of 1974 identifies an abnormal occurrence as abnormal occurrence as an unscheduled incident or event that the Nuclear Regulatory Commission determines to be significant from the standpoint of public health or safety and requires a quarterly report of such events to be made to congress. This report covers the period from January 1 through March 31, 1992. The abnormal occurrences involving medical therapy misadministrations at NRC-licensed facilities are discussed in this report. There were no abnormal occurrences at a nuclear power plant, and none were reported by NRC's Agreement States. The report also contains information updating some previously reported abnormal occurrences.

  19. A Treatment Planning Method for Sequentially Combining Radiopharmaceutical Therapy and External Radiation Therapy;External beam therapy; Radiopharmaceutical therapy; Three-dimensional dosimetry; Treatment planning

    SciTech Connect

    Hobbs, Robert F.; McNutt, Todd; Baechler, Sebastien; He Bin; Esaias, Caroline E.; Frey, Eric C.; Loeb, David M.; Wahl, Richard L.; Shokek, Ori; Sgouros, George

    2011-07-15

    Purpose: Effective cancer treatment generally requires combination therapy. The combination of external beam therapy (XRT) with radiopharmaceutical therapy (RPT) requires accurate three-dimensional dose calculations to avoid toxicity and evaluate efficacy. We have developed and tested a treatment planning method, using the patient-specific three-dimensional dosimetry package 3D-RD, for sequentially combined RPT/XRT therapy designed to limit toxicity to organs at risk. Methods and Materials: The biologic effective dose (BED) was used to translate voxelized RPT absorbed dose (D{sub RPT}) values into a normalized total dose (or equivalent 2-Gy-fraction XRT absorbed dose), NTD{sub RPT} map. The BED was calculated numerically using an algorithmic approach, which enabled a more accurate calculation of BED and NTD{sub RPT}. A treatment plan from the combined Samarium-153 and external beam was designed that would deliver a tumoricidal dose while delivering no more than 50 Gy of NTD{sub sum} to the spinal cord of a patient with a paraspinal tumor. Results: The average voxel NTD{sub RPT} to tumor from RPT was 22.6 Gy (range, 1-85 Gy); the maximum spinal cord voxel NTD{sub RPT} from RPT was 6.8 Gy. The combined therapy NTD{sub sum} to tumor was 71.5 Gy (range, 40-135 Gy) for a maximum voxel spinal cord NTD{sub sum} equal to the maximum tolerated dose of 50 Gy. Conclusions: A method that enables real-time treatment planning of combined RPT-XRT has been developed. By implementing a more generalized conversion between the dose values from the two modalities and an activity-based treatment of partial volume effects, the reliability of combination therapy treatment planning has been expanded.

  20. Annual Report

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    09 THROUGH 09/30/2010 The following Annual Freedom of Information Act report covers the Period 10/01/2009, through 09/30/2010, as required by 5 U.S.C. 552. I. BASIC INFORMATION REGARDING REPORT 1. Kevin T. Hagerty, Director Office of Information Resources, MA-90 U.S. Department of Energy 1000 Independence Ave., SW Washington, DC 20585 202-586-5955 Alexander Morris, FOIA Officer Sheila Jeter, FOIA/Privacy Act Specialist FOIA Office, MA-90 Office of Information Resources U.S. Department of Energy

  1. SANDIA REPORT

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    .VUQ.SAUQ.P6.02; Apply VUQ Practices With Dakota to COBRA-TF for AMA-Relevant Problems Vincent Mousseau Brian Adams Kostadin Ivanov Maria Avramova Robert Salko Taylor Blyth Sandia National Laboratories April 2013: CASL-U-2013-0048-000 SANDIA REPORT SAND2013-3093 Unlimited Release Printed April 2013 CASL L3 Milestone Report: L3:VUQ.SAUQ.P6.02; Apply VUQ Practices with Dakota to COBRA-TF for AMA-Relevant Problems Vincent Mousseau Brian Adams Kostadin Ivanov Maria Avramova Robert Salko Taylor Blyth

  2. Lidar Report

    SciTech Connect

    Wollpert.

    2009-04-01

    This report provides an overview of the LiDAR acquisition methodology employed by Woolpert on the 2009 USDA - Savannah River LiDAR Site Project. LiDAR system parameters and flight and equipment information is also included. The LiDAR data acquisition was executed in ten sessions from February 21 through final reflights on March 2, 2009; using two Leica ALS50-II 150kHz Multi-pulse enabled LiDAR Systems. Specific details about the ALS50-II systems are included in Section 4 of this report.

  3. Usage Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Reports Usage Reports Batch Job Statistics See queue wait times, hours used, top users and other summary statistics for jobs run at NERSC (login required). Read More » Parallel Job Statistics [rest... Read More » Edison Job Size Charts Fraction of Hours Used per Job Size Note: Interactive charts with current and past Cori and Edison data are now available on MyNERSC This chart shows the fraction of hours used on Edison in each of 5 job-core-size bins. 2015 2014 Fraction of Hours Used by Big

  4. Report to Congress on abnormal occurrences, October--December 1991

    SciTech Connect

    Not Available

    1992-03-01

    Section 208 of the Energy Reorganization Act of 1974 identifies an abnormal occurrence of an unscheduled incident or event that the Nuclear Regulatory Commission determines to be significant from the standpoint of public health and safety and requires a quarterly report of such events to be made to Congress. This report covers the period October through December 1991. Five abnormal occurrences at NRC-licensed facilities are discussed in this report. None of these occurrences involved a nuclear power plant. Four involved medical therapy misadministrations and one involved a medical diagnostic misadministration. The NRC's Agreement States reported three abnormal occurrences. Two involved exposures of non-radiation workers and one involved a medical therapy misadministration. The report also contains information that updates some previously reported abnormal occurrences.

  5. Clinical Implementation of Intensity Modulated Proton Therapy for Thoracic Malignancies

    SciTech Connect

    Chang, Joe Y.; Li, Heng; Zhu, X. Ronald; Liao, Zhongxing; Zhao, Lina; Liu, Amy; Li, Yupeng; Sahoo, Narayan; Poenisch, Falk; Gomez, Daniel R.; Wu, Richard; Gillin, Michael; Zhang, Xiaodong

    2014-11-15

    Purpose: Intensity modulated proton therapy (IMPT) can improve dose conformality and better spare normal tissue over passive scattering techniques, but range uncertainties complicate its use, particularly for moving targets. We report our early experience with IMPT for thoracic malignancies in terms of motion analysis and management, plan optimization and robustness, and quality assurance. Methods and Materials: Thirty-four consecutive patients with lung/mediastinal cancers received IMPT to a median 66 Gy(relative biological equivalence [RBE]). All patients were able to undergo definitive radiation therapy. IMPT was used when the treating physician judged that IMPT conferred a dosimetric advantage; all patients had minimal tumor motion (<5 mm) and underwent individualized tumor-motion dose-uncertainty analysis and 4-dimensional (4D) computed tomographic (CT)-based treatment simulation and motion analysis. Plan robustness was optimized by using a worst-case scenario method. All patients had 4D CT repeated simulation during treatment. Results: IMPT produced lower mean lung dose (MLD), lung V{sub 5} and V{sub 20}, heart V{sub 40}, and esophageal V{sub 60} than did IMRT (P<.05) and lower MLD, lung V{sub 20}, and esophageal V{sub 60} than did passive scattering proton therapy (PSPT) (P<.05). D{sub 5} to the gross tumor volume and clinical target volume was higher with IMPT than with intensity modulated radiation therapy or PSPT (P<.05). All cases were analyzed for beam-angle-specific motion, water-equivalent thickness, and robustness. Beam angles were chosen to minimize the effect of respiratory motion and avoid previously treated regions, and the maximum deviation from the nominal dose-volume histogram values was kept at <5% for the target dose and met the normal tissue constraints under a worst-case scenario. Patient-specific quality assurance measurements showed that a median 99% (range, 95% to 100%) of the pixels met the 3% dose/3 mm distance criteria for the

  6. Activity report

    SciTech Connect

    Yu, S W

    2008-08-11

    This report is aimed to show the author's activities to support the LDRD. The title is 'Investigation of the Double-C Behavior in the Pu-Ga Time-Temperature-Transformation Diagram' The sections are: (1) Sample Holder Test; (2) Calculation of x-ray diffraction patterns; (3) Literature search and preparing publications; (4) Tasks Required for APS Experiments; and (5) Communications.

  7. Occurrence Reporting

    Directives, Delegations, and Other Requirements [Office of Management (MA)]

    1995-09-25

    To establish and maintain a system for reporting operations information related to DOE-owned or -operated facilities and processing that information to identify the root causes of Unusual, Off-Normal, and Emergency Occurrences and provide for appropriate corrective action. Cancels DOE 5000.3B.

  8. A virtual simulator designed for collision prevention in proton therapy

    SciTech Connect

    Jung, Hyunuk; Kum, Oyeon; Han, Youngyih Park, Hee Chul; Kim, Jin Sung; Choi, Doo Ho

    2015-10-15

    Purpose: In proton therapy, collisions between the patient and nozzle potentially occur because of the large nozzle structure and efforts to minimize the air gap. Thus, software was developed to predict such collisions between the nozzle and patient using treatment virtual simulation. Methods: Three-dimensional (3D) modeling of a gantry inner-floor, nozzle, and robotic-couch was performed using SolidWorks based on the manufacturer’s machine data. To obtain patient body information, a 3D-scanner was utilized right before CT scanning. Using the acquired images, a 3D-image of the patient’s body contour was reconstructed. The accuracy of the image was confirmed against the CT image of a humanoid phantom. The machine components and the virtual patient were combined on the treatment-room coordinate system, resulting in a virtual simulator. The simulator simulated the motion of its components such as rotation and translation of the gantry, nozzle, and couch in real scale. A collision, if any, was examined both in static and dynamic modes. The static mode assessed collisions only at fixed positions of the machine’s components, while the dynamic mode operated any time a component was in motion. A collision was identified if any voxels of two components, e.g., the nozzle and the patient or couch, overlapped when calculating volume locations. The event and collision point were visualized, and collision volumes were reported. Results: All components were successfully assembled, and the motions were accurately controlled. The 3D-shape of the phantom agreed with CT images within a deviation of 2 mm. Collision situations were simulated within minutes, and the results were displayed and reported. Conclusions: The developed software will be useful in improving patient safety and clinical efficiency of proton therapy.

  9. Porphyrins for boron neutron capture therapy

    DOEpatents

    Miura, Michiko; Gabel, Detlef

    1990-01-01

    Novel compounds for treatment of brain tumors in Boron Neutron Capture Therapy are disclosed. A method for preparing the compounds as well as pharmaceutical compositions containing said compounds are also disclosed. The compounds are water soluble, non-toxic and non-labile boronated porphyrins which show significant uptake and retention in tumors.

  10. Special Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Special Report 193 Chemical Weekly June 16, 2015 T he Japanese rightly called them the seeds of technology'; while in US it is the techno- logy metals'. Unknown to most lay persons, these elements make possible the high-tech world we take for granted today - from electronics, medical technologies and novel green' energy solutions, to supporting a myriad of essential telecommunications and de- fence systems. These elements have come to be recognised as the vital cog in the world of technology

  11. INSPECTION REPORT

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Worker Safety and Health at the Y-12 National Security Complex OAI-L-16-06 December 2015 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 December 22, 2015 MEMORANDUM FOR THE MANAGER, NATIONAL NUCLEAR SECURITY ADMINSTRATION PRODUCTION OFFICE FROM: April G. Stephenson Assistant Inspector General for Inspections Office of Inspector General SUBJECT: INFORMATION: Inspection Report on "Worker Safety and Health at the

  12. ASSESSMENT REPORT

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    REPORT Audit Coverage of Cost Allowability for Lawrence Livermore National Security, LLC, During Fiscal Year 2013 Under Department of Energy Contract No. DE-AC52-07NA27344 OAI-V-16-01 October 2015 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 October 27, 2015 MEMORANDUM FOR THE MANAGER, LIVERMORE FIELD OFFICE FROM: David Sedillo, Director Western Audits Division Office of Inspector General SUBJECT: INFORMATION:

  13. ASSESSMENT REPORT

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    National Security Technologies LLC During Fiscal Years 2012 Through 2014 Under Department of Energy Contract No. DE-AC52-06NA25946 OAI-V-16-07 April 2016 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 April 12, 2016 MEMORANDUM FOR THE MANAGER, NEVADA FIELD OFFICE FROM: David Sedillo Deputy Assistant Inspector General for Audits and Inspections Office of Inspector General SUBJECT: INFORMATION: Assessment Report on

  14. SANDIA REPORT

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    09 Unlimited Release SAND2010-7245P Printed October 2010 Annual Groundwater Monitoring Report Prepared by Sandia National Laboratories, Albuquerque, New Mexico Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000. Approved for public release; further dissemination unlimited Issued

  15. Report Template

    Office of Environmental Management (EM)

    (03-94) Replaces EIA-459B U.S. DEPARTMENT OF ENERGY FEDERAL ASSISTANCE MILESTONE PLAN OMB Control No. 1910-0400 Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information,

  16. SANDIA REPORT

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    3-3735 Unlimited Release Printed June 2013 Site Environmental Report for 2012 Sandia National Laboratories, California Barbara L. Larsen Prepared by Sandia National Laboratories Livermore, California 94550 Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000. Approved for public

  17. SANDIA REPORT

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    5-4277 Unlimited Release Printed June 2015 Site Environmental Report for 2014 Sandia National Laboratories, California Barbara L. Larsen Prepared by Sandia National Laboratories Livermore, California 94550 Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000. Approved for public

  18. SANDIA REPORT

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    5630 Unlimited Release Printed June 2016 Site Environmental Report for 2015 Sandia National Laboratories, California Barbara L. Larsen Prepared by Sandia National Laboratories Livermore, California 94550 Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000. Approved for public

  19. Final Report

    SciTech Connect

    Marchant, Gary E.

    2013-04-23

    This is the final report of a two year project entitled "Governing Nanotechnology Risks and Benefits in the Transition to Regulation: Innovative Public and Private Approaches." This project examined the role of new governance or "soft law" mechanisms such as codes of conduct, voluntary programs and partnership agreements to manage the risks of emerging technologies such as nanotechnology. A series of published or in publication papers and book chapters are attached.

  20. AUDIT REPORT

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    5 Consolidated Financial Statements OAI-FS-16-01 November 2015 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 November 16, 2015 MEMORANDUM FOR THE SECRETARY FROM: Rickey R. Hass Acting Inspector General SUBJECT: INFORMATION: Audit Report: "Department of Energy's Fiscal Year 2015 Consolidated Financial Statements" Pursuant to requirements established by the Government Management Reform Act of 1994, the

  1. AUDIT REPORT

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    5 Financial Statement Audit OAI-FS-16-09 May 2016 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 May 6, 2016 MEMORANDUM FOR THE ADMINISTRATOR, WESTERN AREA POWER ADMINISTRATION FROM: Ricky R. Hass Acting Inspector General SUBJECT: INFORMATION: Audit Report for the "Management Letter on the Western Federal Power System's Fiscal Year 2015 Financial Statement Audit" KPMG LLP (KPMG), our contract auditors,

  2. CRD Report

    SciTech Connect

    Wang, Ucilia

    2007-12-18

    This report has the following articles: (1) Deconstructing Microbes--metagenomic research on bugs in termites relies on new data analysis tools; (2) Popular Science--a nanomaterial research paper in Nano Letters drew strong interest from the scientific community; (3) Direct Approach--researchers employ an algorithm to solve an energy-reduction issue essential in describing complex physical system; and (4) SciDAC Special--A science journal features research on petascale enabling technologies.

  3. AUDIT REPORT

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Management of Information Technology Hardware DOE/IG-0926 October 2014 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 October 30, 2014 MEMORANDUM FOR THE SECRETARY FROM: Gregory H. Friedman Inspector General SUBJECT: INFORMATION: Audit Report on "Follow-up on the Department of Energy's Management of Information Technology Hardware" BACKGROUND The Department of Energy and its facility contractors rely on

  4. AUDIT REPORT

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Status of Cleanup at the Department of Energy's Paducah Site DOE/IG-0937 June 2015 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 June 2, 2015 MEMORANDUM FOR THE SECRETARY FROM: Gregory H. Friedman Inspector General SUBJECT: INFORMATION: Audit Report: "The Status of Cleanup at the Department of Energy's Paducah Site" BACKGROUND The Paducah Gaseous Diffusion Plant is located on the Department of Energy's

  5. AUDIT REPORT

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Lithium Operations at the Y-12 National Security Complex OAI-L-16-05 December 2015 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 December 15, 2015 MEMORANDUM FOR THE ASSISTANT DEPUTY ADMINISTRATOR OF STOCKPILE MANAGEMENT FROM: April G. Stephenson Assistant Inspector General for Inspections Office of Inspector General SUBJECT: INFORMATION: Audit Report on "Lithium Operations at the Y-12 National Security

  6. AUDIT REPORT

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Issues Management at the Los Alamos Field Office OAI-M-16-02 December 2015 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 December 7, 2015 MEMORANDUM FOR THE MANAGER, LOS ALAMOS FIELD OFFICE FROM: Daniel M. Weeber Assistant Inspector General for Audits and Administration Office of Inspector General SUBJECT: INFORMATION: Audit Report on "Issues Management at the Los Alamos Field Office" BACKGROUND The

  7. AUDIT REPORT

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Office of Headquarters Procurement Services Contract Awards Made to Alaska Native Corporations OAI-M-16-09 April 2016 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 April 6, 2016 MEMORANDUM FOR THE DIRECTOR, OFFICE OF MANAGEMENT FROM: April G. Stephenson Assistant Inspector General for Audits and Inspections Office of Inspector General SUBJECT: INFORMATION: Audit Report on "The Department of Energy's Office of

  8. AUDIT REPORT

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Implementation of the Department of Energy's CyberOne Initiative OAI-L-16-11 June 2016 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 June 17, 2016 MEMORANDUM FOR THE CHIEF FINANCIAL OFFICER CHIEF INFORMATION OFFICER FROM: Sarah B. Nelson Assistant Inspector General for Audits and Administration Office of Inspector General SUBJECT: INFORMATION: Audit Report on the "Implementation of the Department of Energy's

  9. AUDIT REPORT

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    of Infrastructure at the Pantex Plant OAI-M-16-12 June 2016 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 June 23, 2016 MEMORANDUM FOR THE MANAGER, NATIONAL NUCLEAR SECURITY ADMINISTRATION PRODUCTION OFFICE FROM: Michelle Anderson Assistant Inspector General for Audits and Inspections Office of Inspector General SUBJECT: INFORMATION: Audit Report on "Management of Infrastructure at the Pantex Plant"

  10. Annual Report

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Report Fiscal Year 2011 Office of Environment, Security, Safety and Health The Office of Fossil Energy: Striving for Environmental, Security, Safety and Health (ESS&H) and Sustainability Excellence I The Department of Energy's Office of Fossil Energy (FE) is dedicated to ensuring that the nation can continue to rely on traditional resources for clean, affordable energy while enhancing sustainability across its three sites: the Strategic Petroleum Reserve (SPR), the National Energy Technology

  11. SPECIAL REPORT

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    The Department of Energy's Freedom of Information Act Process DOE/IG-0946 September 2015 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 September 18, 2015 MEMORANDUM FOR THE DIRECTOR, OFFICE OF MANAGEMENT FROM: Gregory H. Friedman Inspector General SUBJECT: INFORMATION: Special Report: "The Department of Energy's Freedom of Information Act Process" BACKGROUND The Freedom of Information Act (FOIA or the

  12. SPECIAL REPORT

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Management Challenges at the Department of Energy - Fiscal Year 2016 OIG-SR-16-01 November 2015 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 November 16, 2015 MEMORANDUM FOR THE SECRETARY FROM: Rickey R. Hass Acting Inspector General SUBJECT: INFORMATION: Special Report: "Management Challenges at the Department of Energy - Fiscal Year 2016" INTRODUCTION The Department of Energy is responsible for some

  13. Audit Report: IG-0709 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    9 Audit Report: IG-0709 November 17, 2005 Management of the Department's Isotope Program Dating back to the Atomic Energy Act of 1954, the Development Isotopes Department of Energy's (Department) predecessor agency, the Atomic Energy Commission, was authorized to distribute stable and radioactive isotopes at no charge to assist and encourage research on peaceful uses of isotopes involving medical therapy. More recently, the 1990 Energy and Water Appropriations Act consolidated all isotope

  14. Microsoft PowerPoint - MBPCC CAMD Cancer Therapy Program, 12...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Bird Perkins Cancer Center's CAMD Cancer Therapy Research Program CAMD Cancer Therapy Research Program Kenneth R Hogstrom, PhD, PI Chief of Physics Mary Bird Perkins Cancer Center ...

  15. Proton Therapy for Cancer: Current Status, Promise and Challenges...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    March 9, 2016, 4:15pm to 5:30pm Colloquia MBG Auditorium Proton Therapy for Cancer: Current Status, Promise and Challenges Dr. Dennis Mah ProCure Proton Therapy Center Colloquium...

  16. COLLOQUIUM: Proton Therapy for Cancer: Current Status, Promise and

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Challenges | Princeton Plasma Physics Lab May 25, 2016, 1:30pm to 2:45pm Colloquia MBG Auditorium, PPPL (284 cap.) COLLOQUIUM: Proton Therapy for Cancer: Current Status, Promise and Challenges Dr. Dennis Mah ProCure Proton Therapy Center This presentation will provide a physicist's perspective on a proton therapy for cancer treatment. It will include a context of how radiation therapy fits into cancer management overall with an emphasis on the differences between proton and conventional

  17. DOE Research Contributions to Radiation and Cancer Therapy

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    DOE Research Contributions to Radiation and Cancer Therapy Resources with Additional Information Planned radiation treatment Peregrine calculation from Mission Possible: DOE Advanced Biomedical Technology Research, page 10 Over the time span of many years, DOE's research has made many contributions to radiation and cancer therapy, including PEREGRINE and Boron Neutron Capture Therapy (BNCT). 'PEREGRINE, a hardware and software system that addresses the problem of radiation therapy dosage using

  18. ASSESSMENT REPORT

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Stanford University During Fiscal Years 2012 and 2013 Under Department of Energy Contract No. DE-AC02-76SF00515 OAS-V-15-04 September 2015 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 September 21, 2015 MEMORANDUM FOR THE MANAGER, SLAC SITE OFFICE FROM: David Sedillo, Director Western Audits Division Office of Inspector General SUBJECT: INFORMATION: Assessment Report: "Audit Coverage of Cost Allowability for

  19. ASSESSMENT REPORT

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    the University of California During Fiscal Years 2013 and 2014 Under Department of Energy Contract No. DE-AC02-05CH11231 OAI-V-16-10 June 2016 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 June 28, 2016 MEMORANDUM FOR THE MANAGER, BERKELEY SITE OFFICE FROM: David Sedillo Deputy Assistant Inspector General for Audits and Inspections Office of Inspector General SUBJECT: INFORMATION: Assessment Report on "Audit

  20. ASSESSMENT REPORT

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    UT-Battelle LLC During Fiscal Year 2014 Under Department of Energy Contract No. DE-AC05-00OR22725 OAI-V-16-11 July 2016 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 July 29, 2016 MEMORANDUM FOR THE MANAGER, OAK RIDGE NATIONAL LABORATORY SITE OFFICE FROM: Debra K. Solmonson Deputy Assistant Inspector General for Audits and Inspections Office of Inspector General SUBJECT: INFORMATION: Assessment Report on the

  1. Final Report

    SciTech Connect

    R Paul Drake

    2004-01-12

    OAK-B135 This is the final report from the project Hydrodynamics by High-Energy-Density Plasma Flow and Hydrodynamics and Radiation Hydrodynamics with Astrophysical Applications. This project supported a group at the University of Michigan in the invention, design, performance, and analysis of experiments using high-energy-density research facilities. The experiments explored compressible nonlinear hydrodynamics, in particular at decelerating interfaces, and the radiation hydrodynamics of strong shock waves. It has application to supernovae, astrophysical jets, shock-cloud interactions, and radiative shock waves.

  2. Final report

    SciTech Connect

    Dutta, Pulak

    2013-04-01

    The overall goal of this project was the exploration of new ways to make organic and hybrid (organic-inorganic) materials for energy-related applications. Towards this end, our research focused on the structure and behavior of molecular monolayers at interfaces (including floating monolayers, transferred Langmuir-Blodgett monolayers, and self-assembled monolayers), as well as the biomimetic nucleation of inorganic crystals at soft-hard interfaces. The project resulted in a number of 'firsts' and other notable achievements, which are described in the report.

  3. Monthly Biodiesel Production Report

    Gasoline and Diesel Fuel Update

    Monthly Biodiesel Production Report With data for July 2016 Independent Statistics & ... Information Administration | Monthly Biodiesel Production Report This report was ...

  4. Final Report

    SciTech Connect

    Webb, Robert C.; Kamon, Teruki; Toback, David; Safonov, Alexei; Dutta, Bhaskar; Dimitri, Nanopoulos; Pope, Christopher; White, James

    2013-11-18

    Overview The High Energy Physics Group at Texas A&M University is submitting this final report for our grant number DE-FG02-95ER40917. This grant has supported our wide range of research activities for over a decade. The reports contained here summarize the latest work done by our research team. Task A (Collider Physics Program): CMS & CDF Profs. T. Kamon, A. Safonov, and D. Toback co-lead the Texas A&M (TAMU) collider program focusing on CDF and CMS experiments. Task D: Particle Physics Theory Our particle physics theory task is the combined effort of Profs. B. Dutta, D. Nanopoulos, and C. Pope. Task E (Underground Physics): LUX & NEXT Profs. R. Webb and J. White(deceased) lead the Xenon-based underground research program consisting of two main thrusts: the first, participation in the LUX two-phase xenon dark matter search experiment and the second, detector R&D primarily aimed at developing future detectors for underground physics (e.g. NEXT and LZ).

  5. Proposals and Design Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Proposals and Design Reports Proposals and Design Reports Proposal (1204) Proposal Addendum (29304) Physics Case and Detector Technology Report (1204) Technical Design Report ...

  6. The effects of interstitial atoms H and B on magnetic properties and magnetocaloric effect in LaFe{sub 11.5}Al{sub 1.5} compound

    SciTech Connect

    Zhang, D. K.; Zhao, J. L.; Shen, J.; Zhang, H. G.; Yue, M.

    2014-05-14

    The changes in magnetic properties of LaFe{sub 11.5}Al{sub 1.5}H{sub x} and LaFe{sub 11.5}Al{sub 1.5}B{sub y} have been investigated. By introducing interstitial atoms H or B, the magnetic ground state is changed from the antiferromagnetic to the ferromagnetic state, accompanied by significant increases in the saturated magnetization (Ms) and the Curie temperature (T{sub C}). An attractive feature is that the magnetic transition from the second-order to the weakly first-order with increasing hydrogen content compared to the magnetic transition from the weakly first-order to the second-order with increasing boron content. The maximum magnetic entropy change (−ΔS{sub M}) under a field change of 0–5 T increases from 10.1 J/kg · K for hydrogen content x = 0.12 to 12.3 J/kg · K for x = 1.3, while decreases from 9.6 J/kg · K for boron content y = 0.1 to 9.2 J/kg · K for y = 0.3.

  7. Final Report

    SciTech Connect

    Gurney, Kevin R

    2015-01-12

    This document constitutes the final report under DOE grant DE-FG-08ER64649. The organization of this document is as follows: first, I will review the original scope of the proposed research. Second, I will present the current draft of a paper nearing submission to Nature Climate Change on the initial results of this funded effort. Finally, I will present the last phase of the research under this grant which has supported a Ph.D. student. To that end, I will present the graduate student’s proposed research, a portion of which is completed and reflected in the paper nearing submission. This final work phase will be completed in the next 12 months. This final workphase will likely result in 1-2 additional publications and we consider the results (as exemplified by the current paper) high quality. The continuing results will acknowledge the funding provided by DOE grant DE-FG-08ER64649.

  8. Final Report

    SciTech Connect

    Yelton, John Martin; Mitselmakher, Guenakh; Korytov, Andrey; Avery, Paul; Furic, Ivan; Acosta, Darin; Konigsberg, Jacobo; Field, Richard; Matchev, Konstantin; Ramond, Pierre; Thorn, Richard; Sikivie, Pierre; Ray, Heather; Tanner, David

    2013-10-10

    We report on progress in a series of different directions within high energy physics research. 1. Neutrino research in hardware and software on the Minerva and MiniBooNE experiments 2. Experimental particle physics at the hadron colliders, with emphasis on research and development and data analysis on the CMS experiment operating at the CERN LHC. This includes research on the discovery and properties on the Higgs Boson. 3. Educational outreach through the Quarknet program, taking physics research into High School classrooms. 4. Theoretical and Phenomenological High Energy research, covering a broad range of activities ranging from fundamental theoretical issues to areas of immediate phenomenological importance. 5. Experiment searches for the Axion, as part of the ADMX experiment.

  9. Report on reports: nuclear energy

    SciTech Connect

    Darmstadter, J.

    1982-11-01

    A joint report by the Nuclear Energy Agency (of the OECD) and the International Energy Agency, nuclear energy prospects to 2000 surveys the factors shaping the future of nuclear power in the 24-country OECD grouping, 13 of whom were operating nuclear power plants as of the end of 1981. Among the factors reviewed are the long-term economic outlook and its effect on total energy consumption, the role of electricity within aggregate energy use, and the economic and policy determinants governing nuclear's future contribution to electric power capacity and generation. The way in which public confidence bears on the nuclear outlook is mentioned as one of the considerations in the policy process, but this is given rather short shrift for an issue which many feel to be at the heart of the present-day nuclear power dilemma. The report describes areas in which nuclear power could offer notable advantages: 1) competitive electricity costs; 2) resource adequacy; 3) security of supply; and 4) environmental integrity. (JMT)

  10. FY 2013 Reports - Hanford Site

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Impact Statements Environmental Management Performance Reports FY 2016 Reports FY 2015 Reports FY 2014 Reports FY 2013 Reports FY 2012 Reports FY 2011 Reports FY 2010 ...

  11. FY 2011 Reports - Hanford Site

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Impact Statements Environmental Management Performance Reports FY 2016 Reports FY 2015 Reports FY 2014 Reports FY 2013 Reports FY 2012 Reports FY 2011 Reports FY 2010 ...

  12. FY 2016 Reports - Hanford Site

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Impact Statements Environmental Management Performance Reports FY 2016 Reports FY 2015 Reports FY 2014 Reports FY 2013 Reports FY 2012 Reports FY 2011 Reports FY 2010 ...

  13. FY 2015 Reports - Hanford Site

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Impact Statements Environmental Management Performance Reports FY 2016 Reports FY 2015 Reports FY 2014 Reports FY 2013 Reports FY 2012 Reports FY 2011 Reports FY 2010 ...

  14. FY 2014 Reports - Hanford Site

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Impact Statements Environmental Management Performance Reports FY 2016 Reports FY 2015 Reports FY 2014 Reports FY 2013 Reports FY 2012 Reports FY 2011 Reports FY 2010 ...

  15. FY 2012 Reports - Hanford Site

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Impact Statements Environmental Management Performance Reports FY 2016 Reports FY 2015 Reports FY 2014 Reports FY 2013 Reports FY 2012 Reports FY 2011 Reports FY 2010 ...

  16. FY 2010 Reports - Hanford Site

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Impact Statements Environmental Management Performance Reports FY 2016 Reports FY 2015 Reports FY 2014 Reports FY 2013 Reports FY 2012 Reports FY 2011 Reports FY 2010 ...

  17. Cost-Effectiveness Analysis of Intensity Modulated Radiation Therapy Versus 3-Dimensional Conformal Radiation Therapy for Anal Cancer

    SciTech Connect

    Hodges, Joseph C.; Beg, Muhammad S.; Das, Prajnan; Meyer, Jeffrey

    2014-07-15

    Purpose: To compare the cost-effectiveness of intensity modulated radiation therapy (IMRT) and 3-dimensional conformal radiation therapy (3D-CRT) for anal cancer and determine disease, patient, and treatment parameters that influence the result. Methods and Materials: A Markov decision model was designed with the various disease states for the base case of a 65-year-old patient with anal cancer treated with either IMRT or 3D-CRT and concurrent chemotherapy. Health states accounting for rates of local failure, colostomy failure, treatment breaks, patient prognosis, acute and late toxicities, and the utility of toxicities were informed by existing literature and analyzed with deterministic and probabilistic sensitivity analysis. Results: In the base case, mean costs and quality-adjusted life expectancy in years (QALY) for IMRT and 3D-CRT were $32,291 (4.81) and $28,444 (4.78), respectively, resulting in an incremental cost-effectiveness ratio of $128,233/QALY for IMRT compared with 3D-CRT. Probabilistic sensitivity analysis found that IMRT was cost-effective in 22%, 47%, and 65% of iterations at willingness-to-pay thresholds of $50,000, $100,000, and $150,000 per QALY, respectively. Conclusions: In our base model, IMRT was a cost-ineffective strategy despite the reduced acute treatment toxicities and their associated costs of management. The model outcome was sensitive to variations in local and colostomy failure rates, as well as patient-reported utilities relating to acute toxicities.

  18. Final report

    SciTech Connect

    Joseph H. Simmons; Tracie J. Bukowski

    2002-08-07

    determine if photocarriers could be collected. Thus, we tested a variety of semiconductor-glass nano-composite structures for photoconductivity. Tests were conducted in collaboration with the Laser Physics Division at Sandia National Laboratories. Nano-composite samples were formed consisting of Ge nanocrystals embedded in an indium-tin-oxide matrix. Photoconductivity measurements were conducted with exposure of the films to sub-bandgap and super-bandgap light. The results showed a clear photoconductivity effect arising from exposure to super-bandgap light only. These results suggest that the high-efficiency photovoltaic cell structure proposed in DOE sponsored U.S. Patent 5,720,827 is viable. The results of fabrication studies, structural characterization studies and photovoltaic measurements are presented in the report. This report is taken from a PhD dissertation of Tracie J. Bukowski submitted to the University of Florida in May 2002. ''The optical and photoconductive response in germanium quantum dots and indium tin oxide composite thin film structures,'' Dr. Bukowski conducted her PhD study under this grant at the University of Arizona and under Grant No DE-FG05-91ER45462 at the University of Florida, as well as during a two-year fellowship at Sandia National Laboratories.

  19. Gantry for medical particle therapy facility

    DOEpatents

    Trbojevic, Dejan

    2012-05-08

    A particle therapy gantry for delivering a particle beam to a patient includes a beam tube having a curvature defining a particle beam path and a plurality of fixed field magnets sequentially arranged along the beam tube for guiding the particle beam along the particle path. In a method for delivering a particle beam to a patient through a gantry, a particle beam is guided by a plurality of fixed field magnets sequentially arranged along a beam tube of the gantry and the beam is alternately focused and defocused with alternately arranged focusing and defocusing fixed field magnets.

  20. Gantry for medical particle therapy facility

    DOEpatents

    Trbojevic, Dejan

    2013-04-23

    A particle therapy gantry for delivering a particle beam to a patient includes a beam tube having a curvature defining a particle beam path and a plurality of superconducting, variable field magnets sequentially arranged along the beam tube for guiding the particle beam along the particle path. In a method for delivering a particle beam to a patient through a gantry, a particle beam is guided by a plurality of variable field magnets sequentially arranged along a beam tube of the gantry and the beam is alternately focused and defocused with alternately arranged focusing and defocusing variable field magnets.

  1. Acceleration Of Wound Healing Ny Photodynamic Therapy

    DOEpatents

    Hasan, Tayyaba; Hamblin, Michael R.; Trauner, Kenneth

    2000-08-22

    Disclosed is a method for accelerating wound healing in a mammal. The method includes identifying an unhealed wound site or partially-healed wound site in a mammal; administering a photosensitizer to the mammal; waiting for a time period wherein the photosensitizer reaches an effective tissue concentration at the wound site; and photoactivating the photosensitizer at the wound site. The dose of photodynamic therapy is selected to stimulate the production of one or more growth factor by cells at the wound site, without causing tissue destruction.

  2. COMPACT ACCELERATOR CONCEPT FOR PROTON THERAPY

    SciTech Connect

    Caporaso, G; Sampayan, S; Chen, Y; Harris, J; Hawkins, S; Holmes, C; Krogh, M; Nelson, S; Nunnally, W; Paul, A; Poole, B; Rhodes, M; Sanders, D; Selenes, K; Sullivan, J; Wang, L; Watson, J

    2006-08-18

    A new type of compact induction accelerator is under development at the Lawrence Livermore National Laboratory that promises to increase the average accelerating gradient by at least an order of magnitude over that of existing induction machines. The machine is based on the use of high gradient vacuum insulators, advanced dielectric materials and switches and is being developed as a compact flash x-ray radiography source. Research describing an extreme variant of this technology aimed at proton therapy for cancer will be presented.

  3. Biogas Opportunities Roadmap Progress Report (Technical Report...

    Office of Scientific and Technical Information (OSTI)

    Biogas Opportunities Roadmap Progress Report Citation Details In-Document Search Title: Biogas Opportunities Roadmap Progress Report In support of the Obama Administration's ...

  4. Final Report

    SciTech Connect

    Michael C. Weinberg; Lori L. Burgner; Joseph H. Simmons

    2003-05-23

    OAK B135 The formation of metastable crystalline phases in lithium disilicate glass has been a subject of controversy for decades. Here, one aspect of this problem relating to the stability of these non-equilibrium phases when glasses are heated for extended time periods in the nucleation regime is addressed. The results of a systematic experimental investigation on the persistence of metastable phases and the factors that may influence the appearance of such phases, e.g., water content, impurities, glass composition, and glass preparation procedure are presented. Growth rates of lithium disilicate crystals in lithium disilicate glass are measured as a function water concentration in the glass and of temperature in the deeply undercooled regime. The growth rate data obtained in this work are combined with data reported in the literature and used to assess the applicability of standard models of crystal growth for the description of experimental results over a very broad temperature range. The reduced growth rate versus undercooling graph is found to consist of three regimes. For undercoolings less than 140C, the reduced growth rate curve is suggestive of either 2-D surface nucleation or screw dislocation growth. For undercoolings greater than 400C, the reduced growth rate plot suggests the operative crystal growth mechanism is 2-D surface nucleation, but detailed calculations cast doubt upon this conclusion. In the intermediate undercooling range, there appears to be some sort of transitional behavior for which none of the standard models appear to be applicable. Further, it is observed that small differences in the viscosity data employed can produce enormous differences in the predicted growth rates at larger undercoolings. Results of the kinetic analyses conducted herein seem to indicate that the nature of the kinetic rate coefficient used in the standard growth models may be incorrect. Nucleation rates of sodium metasilicate crystals in a sodium silicate

  5. Collimator design for experimental minibeam radiation therapy

    SciTech Connect

    Babcock, Kerry; Sidhu, Narinder; Kundapur, Vijayananda; Ali, Kaiser

    2011-04-15

    Purpose: To design and optimize a minibeam collimator for minibeam radiation therapy studies using a 250 kVp x-ray machine as a simulated synchrotron source. Methods: A Philips RT250 orthovoltage x-ray machine was modeled using the EGSnrc/BEAMnrc Monte Carlo software. The resulting machine model was coupled to a model of a minibeam collimator with a beam aperture of 1 mm. Interaperture spacing and collimator thickness were varied to produce a minibeam with the desired peak-to-valley ratio. Results: Proper design of a minibeam collimator with Monte Carlo methods requires detailed knowledge of the x-ray source setup. For a cathode-ray tube source, the beam spot size, target angle, and source shielding all determine the final valley-to-peak dose ratio. Conclusions: A minibeam collimator setup was created, which can deliver a 30 Gy peak dose minibeam radiation therapy treatment at depths less than 1 cm with a valley-to-peak dose ratio on the order of 23%.

  6. Methods for implementing microbeam radiation therapy

    DOEpatents

    Dilmanian, F. Avraham; Morris, Gerard M.; Hainfeld, James F.

    2007-03-20

    A method of performing radiation therapy includes delivering a therapeutic dose such as X-ray only to a target (e.g., tumor) with continuous broad beam (or in-effect continuous) using arrays of parallel planes of radiation (microbeams/microplanar beams). Microbeams spare normal tissues, and when interlaced at a tumor, form a broad-beam for tumor ablation. Bidirectional interlaced microbeam radiation therapy (BIMRT) uses two orthogonal arrays with inter-beam spacing equal to beam thickness. Multidirectional interlaced MRT (MIMRT) includes irradiations of arrays from several angles, which interleave at the target. Contrast agents, such as tungsten and gold, are administered to preferentially increase the target dose relative to the dose in normal tissue. Lighter elements, such as iodine and gadolinium, are used as scattering agents in conjunction with non-interleaving geometries of array(s) (e.g., unidirectional or cross-fired (intersecting) to generate a broad beam effect only within the target by preferentially increasing the valley dose within the tumor.

  7. Reducing the uncertainties in particle therapy

    SciTech Connect

    Oancea, C.; Shipulin, K. N.; Mytsin, G. V.; Luchin, Y. I.

    2015-02-24

    The use of fundamental Nuclear Physics in Nuclear Medicine has a significant impact in the fight against cancer. Hadrontherapy is an innovative cancer radiotherapy method using nuclear particles (protons, neutrons and ions) for the treatment of early and advanced tumors. The main goal of proton therapy is to deliver high radiation doses to the tumor volume with minimal damage to healthy tissues and organs. The purpose of this work was to investigate the dosimetric errors in clinical proton therapy dose calculation due to the presence of metallic implants in the treatment plan, and to determine the impact of the errors. The results indicate that the errors introduced by the treatment planning systems are higher than 10% in the prediction of the dose at isocenter when the proton beam is passing directly through a metallic titanium alloy implant. In conclusion, we recommend that pencil-beam algorithms not be used when planning treatment for patients with titanium alloy implants, and to consider implementing methods to mitigate the effects of the implants.

  8. Monthly Performance Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... ACCOMPLISHMENTS FY 2016 Hanford Lifecycle Scope, Schedule and Cost Report (Lifecycle ... the FY 2016 Hanford Lifecycle Scope, Schedule and Cost Report (Lifecycle Report). ...

  9. Annual Coal Distribution Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Annual Coal Distribution Report Release Date: April 16, 2015 | Next Release Date: March 2016 | full report | RevisionCorrection Revision to the Annual Coal Distribution Report ...

  10. Metalloporphyrins and their uses as radiosensitizers for radiation therapy

    DOEpatents

    Miura, Michiko; Slatkin, Daniel N.

    2004-07-06

    The present invention covers radiosensitizers containing as an active ingredient halogenated derivatives of boronated porphyrins containing multiple carborane cages having the structure ##STR1## which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies including, but not limited to, boron neutron--capture therapy and photodynamic therapy. The present invention also covers methods for using these radiosensitizers in tumor imaging and cancer treatment.

  11. Oct. 25 Lecture Highlights Treatment Technology of HU's Proton Therapy

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Institute | Jefferson Lab Oct. 25 Lecture Highlights Treatment Technology of HU's Proton Therapy Institute Oct. 25 Lecture Highlights Treatment Technology of HU's Proton Therapy Institute Cynthia Keppel Hampton University Proton Therapy Institute Scientific and Technical Director, Cynthia Keppel, will present a public lecture titled "Accelerating Protons to Save Lives" on Oct. 25 at Jefferson Lab in Newport News. NEWPORT NEWS, Va., Sept. 29, 2011 - Jefferson Lab's 2011 Fall Science

  12. DOE Research Contributions to Radiation and Cancer Therapy

    Office of Scientific and Technical Information (OSTI)

    DOE Research Contributions to Radiation and Cancer Therapy Resources with Additional Information Planned radiation treatment Peregrine calculation from Mission Possible: DOE ...

  13. Shape memory polymer foams for endovascular therapies (Patent...

    Office of Scientific and Technical Information (OSTI)

    Title: Shape memory polymer foams for endovascular therapies A system for occluding a ... Sponsoring Org: USDOE Country of Publication: United States Language: English Subject: 59 ...

  14. Radioisotopes for Medical Diagnostics and Cancer Therapy at BNL...

    Office of Science (SC)

    Radioisotopes for Medical Diagnostics and Cancer Therapy at BNL Nuclear Physics (NP) NP Home About Research Facilities Science Highlights Benefits of NP Applications of Nuclear ...

  15. Cytometric Therapies for Cell Delivery - Energy Innovation Portal

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Advanced Materials Advanced Materials Find More Like This Return to Search Cytometric Therapies for Cell Delivery Maximizing Efficacy of Cell Delivery Oak Ridge National Laboratory ...

  16. Weekly Petroleum Status Report

    Gasoline and Diesel Fuel Update

    Please go to the redesigned Weekly Petroleum Status Report.

  17. Papers and Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Papers, Reports Papers and Reports Bringing together top space science students with internationally recognized researchers at Los Alamos in an educational and collaborative atmosphere. Contacts Director Misa Cowee Email Administrative Assistant Lynea Koshar Email Request more information Email Annual research reports Report 2015 (pdf - 9.35 MB) Report 2014 (pdf - 12.16 MB) Report 2013 (pdf - 29.06 MB) Report 2012 (pdf - 25.42 MB) Report 2011 (pdf - 10.46 MB) Papers, posters, presentations

  18. Hadron Cancer Therapy: Role of Nuclear Reactions

    DOE R&D Accomplishments

    Chadwick, M. B.

    2000-06-20

    Recently it has become feasible to calculate energy deposition and particle transport in the body by proton and neutron radiotherapy beams, using Monte Carlo transport methods. A number of advances have made this possible, including dramatic increases in computer speeds, a better understanding of the microscopic nuclear reaction cross sections, and the development of methods to model the characteristics of the radiation emerging from the accelerator treatment unit. This paper describes the nuclear reaction mechanisms involved, and how the cross sections have been evaluated from theory and experiment, for use in computer simulations of radiation therapy. The simulations will allow the dose delivered to a tumor to be optimized, whilst minimizing the dos given to nearby organs at risk.

  19. Intraoperative radiation therapy in recurrent ovarian cancer

    SciTech Connect

    Yap, O.W. Stephanie . E-mail: stbeast@stanford.edu; Kapp, Daniel S.; Teng, Nelson N.H.; Husain, Amreen

    2005-11-15

    Purpose: To evaluate disease outcomes and complications in patients with recurrent ovarian cancer treated with cytoreductive surgery and intraoperative radiation therapy (IORT). Methods and Materials: A retrospective study of 24 consecutive patients with ovarian carcinoma who underwent secondary cytoreduction and intraoperative radiation therapy at our institution between 1994 and 2002 was conducted. After optimal cytoreductive surgery, IORT was delivered with orthovoltage X-rays (200 kVp) using individually sized and beveled cone applications. Outcomes measures were local control of disease, progression-free interval, overall survival, and treatment-related complications. Results: Of these 24 patients, 22 were available for follow-up analysis. Additional treatment at the time of and after IORT included whole abdominopelvic radiation, 9; pelvic or locoregional radiation, 5; chemotherapy, 6; and no adjuvant treatment, 2. IORT doses ranged from 9-14 Gy (median, 12 Gy). The anatomic sites treated were pelvis (sidewalls, vaginal cuff, presacral area, anterior pubis), para-aortic and paracaval lymph node beds, inguinal region, or porta hepatitis. At a median follow-up of 24 months, 5 patients remain free of disease, whereas 17 patients have recurred, of whom 4 are alive with disease and 13 died from disease. Five patients recurred within the radiation fields for a locoregional relapse rate of 32% and 12 patients recurred at distant sites with a median time to recurrence of 13.7 months. Five-year overall survival was 22% with a median survival of 26 months from time of IORT. Nine patients (41%) experienced Grade 3 toxicities from their treatments. Conclusion: In carefully selected patients with locally recurrent ovarian cancer, combined IORT and tumor reductive surgery is reasonably tolerated and may contribute to achieving local control and disease palliation.

  20. Endoscopic Electron-Beam Cancer Therapy | Argonne National Laboratory

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Endoscopic Electron-Beam Cancer Therapy Technology available for licensing: A successful and cost-effective means of treating cancer in previously inoperable or radiation-sensitive areas of the body. Cost-effective Can treat cancer in inoperable or radiation-sensitive areas PDF icon e-beam_cancer_therapy

  1. [Research programs in radiotherapy]. DOE final report, 1996

    SciTech Connect

    DeNardo, S.J.

    1996-12-31

    Results which have not yet been published in detail are reported here on the following associated studies: Progress in the area of macrocyclic chelates for targeted therapy; Progress in biologic activation with radioimmunoconjugate therapy: Association of molecular receptor increase and tumor response in ChL6/L6 protocol patients; Progress in genetically engineered Lym-1 single chain molecules; Progress in analysis of molecular genetic coded messages to enhance tumor response; Progress on development and validation of planar imaging for therapy planning systems; Progress in development of a 3-D treatment planning system using SPECT; Progress in development of methods to evaluate enhancement of tumor penetration in a murine model; and Progress in clinical applications.

  2. [Purification of {sup 67}Cu]. Progress report

    SciTech Connect

    DeNardo, S.J.

    1994-09-01

    This report documents progress made in several areas of research and describes results which have not yet been published. These areas include: Purification of {sup 67}Cu; Macrocyclic chelates for targeted therapy; Studies of biologic activation associated with molecular receptor increase and tumor response in ChL6/L6 protocol patients; Lym-1 single chain genetically engineered molecules; Analysis of molecular genetic coded messages to enhance tumor response; Human dosimetry and therapeutic human use radiopharmaceuticals; studies in phantoms; Quantitative SPECT; Preclinical studies; and Clinical studies.

  3. Report to Congress on abnormal occurrences, April--June 1989

    SciTech Connect

    Not Available

    1989-10-01

    The Energy Reorganization Act of 1974 identifies an abnormal occurrence as an unscheduled incident or event which the Nuclear Regulatory Commission determines to be significant from the standpoint of public health or safety and requires a quarterly report of such events to be made to Congress. For this reporting period, there was one abnormal occurrence at nuclear power plants licensed to operate involving significant deficiencies in management controls at Slurry Nuclear Power Station. There was one abnormal occurrence under other NRC-issued licenses; the event involved a medical therapy misadministration. One other abnormal occurrence, involving industrial radiography overexposures, was reported by an Agreement State (Texas). 40 refs.

  4. Annual Site Environmental Report Calendar Year 2010

    SciTech Connect

    Kayser, Dan

    2011-01-31

    Procurement Performance Measure. A performance level of 'A-' was achieved in 2010 for Integrated Safety, Health and Environmental Protection. As reported in Site Environmental Reports for prior years, the Laboratory's Environmental Management System (EMS) has been integrated into the Laboratory's Integrated Safety Management System since 2005. The integration of EMS into the way the Laboratory does business allows the Laboratory to systematically review, address and respond to the Laboratory's environmental impacts. The Laboratory's EMS was audited in April 2009 by DOE-CH. There were four 'Sufficiently in Conformity' findings as a result of the audit. All four findings were tracked in the Laboratory's corrective action database for completion. Beryllium was used routinely at Ames Laboratory in the 1940's and 1950's in processes developed for the production of highly pure uranium and thorium in support of the historic Manhattan Project. Laboratory metallurgists also worked on a process to produce pure beryllium metal from beryllium fluoride. In the early 1950's, beryllium oxide powder was used to produce shaped beryllium and crucibles. As a result of that work, beryllium contamination now exists in many interstitial spaces (e.g., utility chases) and ventilation systems in Wilhelm, Spedding and Metals Development buildings. Extensive characterization and remediation efforts have occurred in 2009 and 2010 in order to better understand the extent of the contamination. Analysis of extensive sampling data suggests that a fairly wide dispersion of beryllium occurred (most likely in the 1950's and 60's) in Wilhelm Hall and in certain areas of Spedding Hall and Metals Development. Area air-sampling results and work-area surface characterizations indicate the exposure potential to current workers, building visitors and the public remains extremely low. This information is now used to guide cleaning efforts and to provide worker protection during remodeling and maintenance activities

  5. Multifield Optimization Intensity Modulated Proton Therapy for Head and Neck Tumors: A Translation to Practice

    SciTech Connect

    Frank, Steven J.; Cox, James D.; Gillin, Michael; Mohan, Radhe; Garden, Adam S.; Rosenthal, David I.; Gunn, G. Brandon; Weber, Randal S.; Kies, Merrill S.; Lewin, Jan S.; Munsell, Mark F.; Palmer, Matthew B.; Sahoo, Narayan; Zhang, Xiaodong; Liu, Wei; Zhu, X. Ronald

    2014-07-15

    Background: We report the first clinical experience and toxicity of multifield optimization (MFO) intensity modulated proton therapy (IMPT) for patients with head and neck tumors. Methods and Materials: Fifteen consecutive patients with head and neck cancer underwent MFO-IMPT with active scanning beam proton therapy. Patients with squamous cell carcinoma (SCC) had comprehensive treatment extending from the base of the skull to the clavicle. The doses for chemoradiation therapy and radiation therapy alone were 70 Gy and 66 Gy, respectively. The robustness of each treatment plan was also analyzed to evaluate sensitivity to uncertainties associated with variations in patient setup and the effect of uncertainties with proton beam range in patients. Proton beam energies during treatment ranged from 72.5 to 221.8 MeV. Spot sizes varied depending on the beam energy and depth of the target, and the scanning nozzle delivered the spot scanning treatment “spot by spot” and “layer by layer.” Results: Ten patients presented with SCC and 5 with adenoid cystic carcinoma. All 15 patients were able to complete treatment with MFO-IMPT, with no need for treatment breaks and no hospitalizations. There were no treatment-related deaths, and with a median follow-up time of 28 months (range, 20-35 months), the overall clinical complete response rate was 93.3% (95% confidence interval, 68.1%-99.8%). Xerostomia occurred in all 15 patients as follows: grade 1 in 10 patients, grade 2 in 4 patients, and grade 3 in 1 patient. Mucositis within the planning target volumes was seen during the treatment of all patients: grade 1 in 1 patient, grade 2 in 8 patients, and grade 3 in 6 patients. No patient experienced grade 2 or higher anterior oral mucositis. Conclusions: To our knowledge, this is the first clinical report of MFO-IMPT for head and neck tumors. Early clinical outcomes are encouraging and warrant further investigation of proton therapy in prospective clinical trials.

  6. NERSC Annual Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Annual Reports NERSC Annual Reports Sort by: Default | Name 2015AnnualReportcover NERSC Annual Report 2015 Download Image: 2015AnnualReportcover.png | png | 542 KB Download File: 2015NERSCAnnualReportFinal.pdf | pdf | 4.8 MB 2014cover.jpg NERSC Annual Report 2014 Download Image: 2014cover.jpg | jpg | 202 KB Download File: 2014NERSCAnnualReport.pdf | pdf | 6.1 MB 2013-Annual-Report-cover.png NERSC Annual Report 2013 Download Image: 2013-Annual-Report-cover.png | png | 645 KB Download File:

  7. Report to Congress on abnormal occurrences, January--March 1989

    SciTech Connect

    Not Available

    1989-08-01

    Section 208 of the Energy Reorganization Act of 1974 identifies an abnormal occurrence as an unscheduled incident or event which the Nuclear Regulatory Commission determines to be significant from the standpoint of public health and safety and requires a Quarterly report of such events to be made to Congress. This report covers the period January 1 to March 31, 1989. For this reporting period, there were two abnormal occurrences at nuclear power plants licensed to operate. The first had generic implications and involved a plug failure resulting in a steam generator tube leak at North Anna Unit 1. The second involved a steam generator tube rupture at McGuire Unit 1. There were three abnormal occurrences under other NRC-issued licenses. Two involved medical therapy misadministrations and one involved a medical diagnostic misadministration. There were no abnormal occurrences reported by the Agreement States. The report also contains information updating some previously reported abnormal occurrences.

  8. Effects of Voice Rehabilitation After Radiation Therapy for Laryngeal Cancer: A Randomized Controlled Study

    SciTech Connect

    Tuomi, Lisa; Andrll, Paulin

    2014-08-01

    Background: Patients treated with radiation therapy for laryngeal cancer often experience voice problems. The aim of this randomized controlled trial was to assess the efficacy of voice rehabilitation for laryngeal cancer patients after having undergone radiation therapy and to investigate whether differences between different tumor localizations with regard to rehabilitation outcomes exist. Methods and Materials: Sixty-nine male patients irradiated for laryngeal cancer participated. Voice recordings and self-assessments of communicative dysfunction were performed 1 and 6 months after radiation therapy. Thirty-three patients were randomized to structured voice rehabilitation with a speech-language pathologist and 36 to a control group. Furthermore, comparisons with 23 healthy control individuals were made. Acoustic analyses were performed for all patients, including the healthy control individuals. The Swedish version of the Self Evaluation of Communication Experiences after Laryngeal Cancer and self-ratings of voice function were used to assess vocal and communicative function. Results: The patients who received vocal rehabilitation experienced improved self-rated vocal function after rehabilitation. Patients with supraglottic tumors who received voice rehabilitation had statistically significant improvements in voice quality and self-rated vocal function, whereas the control group did not. Conclusion: Voice rehabilitation for male patients with laryngeal cancer is efficacious regarding patient-reported outcome measurements. The patients experienced better voice function after rehabilitation. Patients with supraglottic tumors also showed an improvement in terms of acoustic voice outcomes. Rehabilitation with a speech-language pathologist is recommended for laryngeal cancer patients after radiation therapy, particularly for patients with supraglottic tumors.

  9. Report to congress on abnormal occurrences: January--March 1992. Volume 15, No. 1

    SciTech Connect

    Not Available

    1992-07-01

    Section 208 of the Energy Reorganization Act of 1974 identifies an abnormal occurrence as abnormal occurrence as an unscheduled incident or event that the Nuclear Regulatory Commission determines to be significant from the standpoint of public health or safety and requires a quarterly report of such events to be made to congress. This report covers the period from January 1 through March 31, 1992. The abnormal occurrences involving medical therapy misadministrations at NRC-licensed facilities are discussed in this report. There were no abnormal occurrences at a nuclear power plant, and none were reported by NRC`s Agreement States. The report also contains information updating some previously reported abnormal occurrences.

  10. Proton minibeam radiation therapy: Experimental dosimetry evaluation

    SciTech Connect

    Peucelle, C.; Martínez-Rovira, I.; Prezado, Y.; Nauraye, C.; Patriarca, A.; Hierso, E.; Fournier-Bidoz, N.

    2015-12-15

    Purpose: Proton minibeam radiation therapy (pMBRT) is a new radiotherapy (RT) approach that allies the inherent physical advantages of protons with the normal tissue preservation observed when irradiated with submillimetric spatially fractionated beams. This dosimetry work aims at demonstrating the feasibility of the technical implementation of pMBRT. This has been performed at the Institut Curie - Proton Therapy Center in Orsay. Methods: Proton minibeams (400 and 700 μm-width) were generated by means of a brass multislit collimator. Center-to-center distances between consecutive beams of 3200 and 3500 μm, respectively, were employed. The (passive scattered) beam energy was 100 MeV corresponding to a range of 7.7 cm water equivalent. Absolute dosimetry was performed with a thimble ionization chamber (IBA CC13) in a water tank. Relative dosimetry was carried out irradiating radiochromic films interspersed in a IBA RW3 slab phantom. Depth dose curves and lateral profiles at different depths were evaluated. Peak-to-valley dose ratios (PVDR), beam widths, and output factors were also assessed as a function of depth. Results: A pattern of peaks and valleys was maintained in the transverse direction with PVDR values decreasing as a function of depth until 6.7 cm. From that depth, the transverse dose profiles became homogeneous due to multiple Coulomb scattering. Peak-to-valley dose ratio values extended from 8.2 ± 0.5 at the phantom surface to 1.08 ± 0.06 at the Bragg peak. This was the first time that dosimetry in such small proton field sizes was performed. Despite the challenge, a complete set of dosimetric data needed to guide the first biological experiments was achieved. Conclusions: pMBRT is a novel strategy in order to reduce the side effects of RT. This works provides the experimental proof of concept of this new RT method: clinical proton beams might allow depositing a (high) uniform dose in a brain tumor located in the center of the brain (7.5 cm depth

  11. Sustained virological response with intravenous silibinin: individualized IFN-free therapy via real-time modelling of HCV kinetics

    DOE PAGES [OSTI]

    Dahari, Harel; Shteingart, Shimon; Gafanovich, Inna; Cotler, Scott J.; D'Amato, Massimo; Pohl, Ralf T.; Weiss, Gali; Ashkenazi, Yaakov J.; Tichler, Thomas; Goldin, Eran; et al

    2014-10-10

    Providing here our aims and project background, we note that intravenous silibinin (SIL) is a potent antiviral agent against hepatitis C virus (HCV) genotype-1. In this proof of concept case-study we tested: (i) whether interferon-alfa (IFN)-free treatment with SIL plus ribavirin (RBV) can achieve sustained virological response (SVR); (ii) whether SIL is safe and feasible for prolonged duration of treatment and (iii) whether mathematical modelling of early on-treatment HCV kinetics can guide duration of therapy to achieve SVR. With our method, a 44 year-old female HCV-(genotype-1)-infected patient who developed severe psychiatric adverse events to a previous course of pegIFN+RBV, initiatedmore » combination treatment with 1200 mg/day of SIL, 1200 mg/day of RBV and 6000 u/day vitamin D. Blood samples were collected frequently till week 4, thereafter every 1-12 weeks until the end of therapy. The standard biphasic mathematical model with time-varying SIL effectiveness was used to predict the duration of therapy to achieve SVR. Our results show that, based on modelling the observed viral kinetics during the first 3 weeks of treatment, SVR was predicted to be achieved within 34 weeks of therapy. Provided with this information, the patient agreed to complete 34 weeks of treatment. IFN-free treatment with SIL+RBV was feasible, safe and achieved SVR (week-33). In conclusion, we report, for the first time, the use of real-time mathematical modelling of HCV kinetics to individualize duration of IFN-free therapy and to empower a patient to participate in shared decision making regarding length of treatment. SIL-based individualized therapy provides a treatment option for patients who do not respond to or cannot receive other HCV agents and should be further validated.« less

  12. Brachial Plexus-Associated Neuropathy After High-Dose Radiation Therapy for Head-and-Neck Cancer

    SciTech Connect

    Chen, Allen M.; Hall, William H.; Li, Judy; Beckett, Laurel; Farwell, D. Gregory; Lau, Derick H.; Purdy, James A.

    2012-09-01

    Purpose: To identify clinical and treatment-related predictors of brachial plexus-associated neuropathies after radiation therapy for head-and-neck cancer. Methods and Materials: Three hundred thirty patients who had previously completed radiation therapy for head-and-neck cancer were prospectively screened using a standardized instrument for symptoms of neuropathy thought to be related to brachial plexus injury. All patients were disease-free at the time of screening. The median time from completion of radiation therapy was 56 months (range, 6-135 months). One-hundred fifty-five patients (47%) were treated by definitive radiation therapy, and 175 (53%) were treated postoperatively. Radiation doses ranged from 50 to 74 Gy (median, 66 Gy). Intensity-modulated radiation therapy was used in 62% of cases, and 133 patients (40%) received concurrent chemotherapy. Results: Forty patients (12%) reported neuropathic symptoms, with the most common being ipsilateral pain (50%), numbness/tingling (40%), motor weakness, and/or muscle atrophy (25%). When patients with <5 years of follow-up were excluded, the rate of positive symptoms increased to 22%. On univariate analysis, the following factors were significantly associated with brachial plexus symptoms: prior neck dissection (p = 0.01), concurrent chemotherapy (p = 0.01), and radiation maximum dose (p < 0.001). Cox regression analysis confirmed that both neck dissection (p < 0.001) and radiation maximum dose (p < 0.001) were independently predictive of symptoms. Conclusion: The incidence of brachial plexus-associated neuropathies after radiation therapy for head-and-neck cancer may be underreported. In view of the dose-response relationship identified, limiting radiation dose to the brachial plexus should be considered when possible.

  13. Sustained virological response with intravenous silibinin: individualized IFN-free therapy via real-time modelling of HCV kinetics

    SciTech Connect

    Dahari, Harel; Shteingart, Shimon; Gafanovich, Inna; Cotler, Scott J.; D'Amato, Massimo; Pohl, Ralf T.; Weiss, Gali; Ashkenazi, Yaakov J.; Tichler, Thomas; Goldin, Eran; Lurie, Yoav

    2014-10-10

    Providing here our aims and project background, we note that intravenous silibinin (SIL) is a potent antiviral agent against hepatitis C virus (HCV) genotype-1. In this proof of concept case-study we tested: (i) whether interferon-alfa (IFN)-free treatment with SIL plus ribavirin (RBV) can achieve sustained virological response (SVR); (ii) whether SIL is safe and feasible for prolonged duration of treatment and (iii) whether mathematical modelling of early on-treatment HCV kinetics can guide duration of therapy to achieve SVR. With our method, a 44 year-old female HCV-(genotype-1)-infected patient who developed severe psychiatric adverse events to a previous course of pegIFN+RBV, initiated combination treatment with 1200 mg/day of SIL, 1200 mg/day of RBV and 6000 u/day vitamin D. Blood samples were collected frequently till week 4, thereafter every 1-12 weeks until the end of therapy. The standard biphasic mathematical model with time-varying SIL effectiveness was used to predict the duration of therapy to achieve SVR. Our results show that, based on modelling the observed viral kinetics during the first 3 weeks of treatment, SVR was predicted to be achieved within 34 weeks of therapy. Provided with this information, the patient agreed to complete 34 weeks of treatment. IFN-free treatment with SIL+RBV was feasible, safe and achieved SVR (week-33). In conclusion, we report, for the first time, the use of real-time mathematical modelling of HCV kinetics to individualize duration of IFN-free therapy and to empower a patient to participate in shared decision making regarding length of treatment. SIL-based individualized therapy provides a treatment option for patients who do not respond to or cannot receive other HCV agents and should be further validated.

  14. Voice Quality After Treatment of Early Vocal Cord Cancer: A Randomized Trial Comparing Laser Surgery With Radiation Therapy

    SciTech Connect

    Aaltonen, Leena-Maija; Rautiainen, Noora; Sellman, Jaana; Saarilahti, Kauko; Mkitie, Antti; Rihkanen, Heikki; Laranne, Jussi; Kleemola, Leenamaija; Wigren, Tuija; Sala, Eeva; Lindholm, Paula; Grenman, Reidar; Joensuu, Heikki

    2014-10-01

    Objective: Early laryngeal cancer is usually treated with either transoral laser surgery or radiation therapy. The quality of voice achieved with these treatments has not been compared in a randomized trial. Methods and Materials: Male patients with carcinoma limited to 1 mobile vocal cord (T1aN0M0) were randomly assigned to receive either laser surgery (n=32) or external beam radiation therapy (n=28). Surgery consisted of tumor excision with a CO{sub 2} laser with the patient under general anaesthesia. External beam radiation therapy to the larynx was delivered to a cumulative dose of 66Gy in 2-Gy daily fractions over 6.5weeks. Voice quality was assessed at baseline and 6 and 24months after treatment. The main outcome measures were expert-rated voice quality on a grade, roughness, breathiness, asthenia, and strain (GRBAS) scale, videolaryngostroboscopic findings, and the patients' self-rated voice quality and its impact on activities of daily living. Results: Overall voice quality between the groups was rated similar, but voice was more breathy and the glottal gap was wider in patients treated with laser surgery than in those who received radiation therapy. Patients treated with radiation therapy reported less hoarseness-related inconvenience in daily living 2years after treatment. Three patients in each group had local cancer recurrence within 2years from randomization. Conclusions: Radiation therapy may be the treatment of choice for patients whose requirements for voice quality are demanding. Overall voice quality was similar in both treatment groups, however, indicating a need for careful consideration of patient-related factors in the choice of a treatment option.

  15. Report to Congress on abnormal occurrences, October--December 1991. Volume 14, No. 4

    SciTech Connect

    Not Available

    1992-03-01

    Section 208 of the Energy Reorganization Act of 1974 identifies an abnormal occurrence of an unscheduled incident or event that the Nuclear Regulatory Commission determines to be significant from the standpoint of public health and safety and requires a quarterly report of such events to be made to Congress. This report covers the period October through December 1991. Five abnormal occurrences at NRC-licensed facilities are discussed in this report. None of these occurrences involved a nuclear power plant. Four involved medical therapy misadministrations and one involved a medical diagnostic misadministration. The NRC`s Agreement States reported three abnormal occurrences. Two involved exposures of non-radiation workers and one involved a medical therapy misadministration. The report also contains information that updates some previously reported abnormal occurrences.

  16. Application of Monte Carlo Methods in Molecular Targeted Radionuclide Therapy

    SciTech Connect

    Hartmann Siantar, C; Descalle, M-A; DeNardo, G L; Nigg, D W

    2002-02-19

    Targeted radionuclide therapy promises to expand the role of radiation beyond the treatment of localized tumors. This novel form of therapy targets metastatic cancers by combining radioactive isotopes with tumor-seeking molecules such as monoclonal antibodies and custom-designed synthetic agents. Ultimately, like conventional radiotherapy, the effectiveness of targeted radionuclide therapy is limited by the maximum dose that can be given to a critical, normal tissue, such as bone marrow, kidneys, and lungs. Because radionuclide therapy relies on biological delivery of radiation, its optimization and characterization are necessarily different than for conventional radiation therapy. We have initiated the development of a new, Monte Carlo transport-based treatment planning system for molecular targeted radiation therapy as part of the MINERVA treatment planning system. This system calculates patient-specific radiation dose estimates using a set of computed tomography scans to describe the 3D patient anatomy, combined with 2D (planar image) and 3D (SPECT, or single photon emission computed tomography) to describe the time-dependent radiation source. The accuracy of such a dose calculation is limited primarily by the accuracy of the initial radiation source distribution, overlaid on the patient's anatomy. This presentation provides an overview of MINERVA functionality for molecular targeted radiation therapy, and describes early validation and implementation results of Monte Carlo simulations.

  17. Cold atmospheric plasma in cancer therapy

    SciTech Connect

    Keidar, Michael; Shashurin, Alex; Volotskova, Olga; Ann Stepp, Mary; Srinivasan, Priya; Sandler, Anthony; Trink, Barry

    2013-05-15

    Recent progress in atmospheric plasmas has led to the creation of cold plasmas with ion temperature close to room temperature. This paper outlines recent progress in understanding of cold plasma physics as well as application of cold atmospheric plasma (CAP) in cancer therapy. Varieties of novel plasma diagnostic techniques were developed recently in a quest to understand physics of CAP. It was established that the streamer head charge is about 10{sup 8} electrons, the electrical field in the head vicinity is about 10{sup 7} V/m, and the electron density of the streamer column is about 10{sup 19} m{sup −3}. Both in-vitro and in-vivo studies of CAP action on cancer were performed. It was shown that the cold plasma application selectively eradicates cancer cells in-vitro without damaging normal cells and significantly reduces tumor size in-vivo. Studies indicate that the mechanism of action of cold plasma on cancer cells is related to generation of reactive oxygen species with possible induction of the apoptosis pathway. It is also shown that the cancer cells are more susceptible to the effects of CAP because a greater percentage of cells are in the S phase of the cell cycle.

  18. Monthly Report 2015

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Report 2015 Monthly Report for the Reporting Period ending November 30, 2015, as required by NMED Administrative Orders dated February 27, 2014 and May 12, 2014, as Amended by NMED ...

  19. Basic Energy Sciences Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Basic Energy Sciences Reports Basic Energy Sciences Reports The list below of Basic Energy ... The report originated from a January 25, 2005, request from the Office of Science and is ...

  20. Report: RFP0001

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    1 of 5 Report: RFP0001 Fiscal Year: 2010 Fiscal Month: 05 Financial Plan Number: 5 Rpt ... RL14383 - AdvanceMed Hanford Financial Plan Report - Detail Report Generated on: February ...

  1. Thiourea derivatives, methods of their preparation and their use in neutron capture therapy of malignant melanoma

    DOEpatents

    Gabel, Detlef

    1991-01-01

    The present invention pertains to boron containing thiouracil derivatives, their method of preparations, and their use in the therapy of malignant melanoma using boron neutron capture therapy.

  2. Boron containing compounds and their preparation and use in neutron capture therapy

    DOEpatents

    Gabel, Detlef

    1992-01-01

    The present invention pertains to boron containing thiouracil derivatives, their method of preparations, and their use in the therapy of malignant melanoma using boron neutron capture therapy.

  3. Annual Reports - Hanford Site

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Annual Reports Soil & Groundwater Home Annual Reports Environmental Data Access Administrative Record Annual Reports Email Email Page | Print Print Page | Text Increase Font Size Decrease Font Size NEW The Groundwater Remediation Project issues an annual report describing its accomplishments and plans. The projects associated with the Groundwater Remediation Project also issue periodic status reports. Those reports can be found in this section. Title Issue Date Rev. Document Information

  4. Reporting | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Emergency Situation Reports Reports on energy related activities resulting from natural and man-made disasters. Energy Assurance Daily Energy Assurance Daily provides a summary of ...

  5. Annual Report on U

    Energy.gov [DOE] (indexed site)

    4 2013 WIND TECHNOLOGIES MARKET REPORT This report is being disseminated by the U.S. ... from the advice and comments of five wind industry and trade association ...

  6. Benefits Plan Reports & Notices

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Benefits Plan Reports & Notices Benefits Plan Reports & Notices Employees and retirees are the building blocks of the Lab's success. Our employees get to contribute to the most ...

  7. Monthly Performance Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... planned work scope at FY 2014 Omnibus Budget levels, and the FY 2015 OMB Budget Request. ... Hanford Lifecycle Scope, Schedule & Cost Report (Lifecycle Report) - MSA, working in ...

  8. Monthly Performance Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... MSA's environmental scope with safety and health, and combine the radiological programs. ... Hanford Lifecycle Scope, Schedule & Cost Report (Lifecycle Report) - The 2014 Lifecycle ...

  9. Monthly Performance Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... Veritas in September. 2016 Hanford Lifecycle Scope, Schedule and Cost Report - MSA submitted the Final 2016 Hanford Lifecycle Scope, Schedule and Cost Report to RL on December 29, ...

  10. Monthly Performance Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... Report - MSA completed the 2013 Hanford Lifecycle Scope, Schedule and Cost Report. ... implementation plan to scope out program development and implementation activities. ...

  11. PGI Bug Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    PGI PGI Bug Reports PGI Bug Reports Internal compiler error for function pointer with identically named arguments June 9, 2015 by Scott French, NERSC USG Status: Bug 21435...

  12. DRAFT AUDIT REPORT

    Energy.gov [DOE] (indexed site)

    Assessment Report Assessment of Audit Coverage of Cost Allowability for Bechtel Marine ... INFORMATION: Report on "Assessment of Audit Coverage of Cost Allowability for Bechtel ...

  13. Uranium Purchases Report

    Reports and Publications

    1996-01-01

    Final issue. This report details natural and enriched uranium purchases as reported by owners and operators of commercial nuclear power plants. 1996 represents the most recent publication year.

  14. Papers and Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Papers, Reports Papers and Reports Bringing together top space science students with ... or papers related to your Los Alamos Space Weather Summer School project listed here, ...

  15. Quarterly Progress Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Quarterly Progress Reports Quarterly Progress Reports Investigating the field of high energy physics through experiments that strengthen our fundamental understanding of matter,...

  16. Annual Performance Report

    Office of Legacy Management (LM)

    Department of Energy Annual Performance Report, Shiprock, New Mexico October 2014 Doc. ... 25 Annual Performance Report, Shiprock, New Mexico U.S. Department of Energy Doc. No. ...

  17. FY 2008 Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Environmental Management Monthly Reports - FY 2008 The Department of Energy Nevada Field Office Environmental Management Program creates monthly reports for the NSSAB. These...

  18. FY 2007 Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Environmental Management Monthly Reports - FY 2007 The Department of Energy Nevada Field Office Environmental Management Program creates monthly reports for the NSSAB. These...

  19. FY 2011 Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Environmental Management Monthly Reports - FY 2011 The Department of Energy Nevada Field Office Environmental Management Program creates monthly reports for the NSSAB. These...

  20. FY 2009 Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Environmental Management Monthly Reports - FY 2009 The Department of Energy Nevada Field Office Environmental Management Program creates monthly reports for the NSSAB. These...

  1. FY 2010 Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Environmental Management Monthly Reports - FY 2010 The Department of Energy Nevada Field Office Environmental Management Program creates monthly reports for the NSSAB. These...

  2. Inhibition of Axl improves the targeted therapy against ALK-mutated neuroblastoma

    SciTech Connect

    Xu, Fei; Li, Hongling; Sun, Yong

    2014-11-28

    Highlights: • First reported Axl is co-expressed with ALK in neuroblastoma tissues and cell lines. • Axl activation promotes cell growth and impairs the efficiency of ALK inhibitor. • Further found silence of Axl leads to increased sensitivity to ALK inhibitors. • Axl inhibitor promotes the efficiency of targeted therapy in vitro and in vivo. • Axl activation should be considered in the clinical application of ALK inhibitors. - Abstract: Neuroblastoma (NB) patients harboring mutated ALK can be expected to potentially benefit from targeted therapy based on ALK tyrosine kinase inhibitor (TKI), such as crizotinib and ceritinib. However, the effect of the treatment varies with different individuals, although with the same genic changes. Axl receptor tyrosine kinase is expressed in a variety of human cancers, but little data are reported in NB, particularly in which carrying mutated ALK. In this study, we focus on the roles of Axl in ALK-mutated NB for investigating rational therapeutic strategy. We found that Axl is expressed in ALK-positive NB tissues and cell lines, and could be effectively activated by its ligand GAS6. Ligand-dependent Axl activation obviously rescued crizotinib-mediated suppression of cell proliferation in ALK-mutated NB cells. Genetic inhibition of Axl with specific small interfering RNA markedly increased the sensitivity of cells to ALK-TKIs. Furthermore, a small-molecule inhibitor of Axl significantly enhanced ALK-targeted therapy, as an increased frequency of apoptosis was observed in NB cells co-expressing ALK and Axl. Taken together, our results demonstrated that activation of Axl could lead to insensitivity to ALK inhibitors, and dual inhibition of ALK and Axl might be a potential therapeutic strategy against ALK-mutated NB.

  3. Health status of young children with cancer following discontinuation of therapy

    SciTech Connect

    Pastore, G.; Zurlo, M.G.; Acquaviva, A.; Calculli, G.; Castello, M.; Ceci, A.; Di Tullio, M.L.; Gandus, S.; Macchia, P.; Di Montezemolo, L.C.

    1987-01-01

    This paper reports late effects and health status of 198 children who had cancer or leukemia diagnosed under 2 years of age and their therapies electively withdrawn. This series (92 neuroblastoma (NBL), 57 Wilms' tumor (WT), 46 acute lymphoblastic leukemia (ALL), and 3 non-Hodgkin's lymphoma) was followed for 1-12 years after discontinuation of therapy. Thirty-three children were diagnosed before 1973, 92 between 1973 and 1977, and 73 after 1977 in 16 Italian Pediatric Oncology Centers. As of December 1983, 176 children were reported to be alive and without evidence of primary cancer by physicians responsible for their care. One child died from a second primary tumor, two from late recurrences of the primary cancer, and three from other causes; eight were alive with evidence of primary cancer; and eight were lost to follow-up. Kyphoscoliosis was found in 22 children and other musculoskeletal anomalies in 8. Neurological sequelae were observed in 8 of 35 children with ALL treated with radiotherapy (RT) and intrathecal methotrexate. All but one were in continuous complete remission when they developed seizures (three cases), leukoencephalopathy (three cases), or intracerebral calcifications (two cases). One child had cardiomyopathy and subsequently died from cardiac failure: he had received doxorubicin (400 mg/m2) and mediastinal RT (13 Gy) for NBL. Growth impairments were observed in children with NBL and WT.

  4. The M. D. Anderson proton therapy system

    SciTech Connect

    Smith, Alfred; Gillin, Michael; Bues, Martin; Zhu, X. Ronald; Suzuki, Kazumichi; Mohan, Radhe; Woo, Shiao; Lee, Andrew; Komaki, Ritsko; Cox, James; Hiramoto, Kazuo; Akiyama, Hiroshi; Ishida, Takayuki; Sasaki, Toshie; Matsuda, Koji

    2009-09-15

    Purpose: The purpose of this study is to describe University of Texas M. D. Anderson proton therapy system (PTC-H) including the accelerator, beam transport, and treatment delivery systems, the functionality and clinical parameters for passive scattering and pencil beam scanning treatment modes, and the results of acceptance tests. Methods: The PTC-H has a synchrotron (70-250 MeV) and four treatment rooms. An overall control system manages the treatment, physics, and service modes of operation. An independent safety system ensures the safety of patients, staff, and equipment. Three treatment rooms have isocentric gantries and one room has two fixed horizontal beamlines, which include a large-field treatment nozzle, used primarily for prostate treatments, and a small-field treatment nozzle for ocular treatments. Two gantry treatment rooms and the fixed-beam treatment room have passive scattering nozzles. The third gantry has a pencil beam scanning nozzle for the delivery of intensity modulated proton treatments (IMPT) and single field uniform dose (SFUD) treatments. The PTC-H also has an experimental room with a fixed horizontal beamline and a passive scattering nozzle. The equipment described above was provided by Hitachi, Ltd. Treatment planning is performed using the Eclipse system from Varian Medical Systems and data management is handled by the MOSAIQ system from IMPAC Medical Systems, Inc. The large-field passive scattering nozzles use double scattering systems in which the first scatterers are physically integrated with the range modulation wheels. The proton beam is gated on the rotating range modulation wheels at gating angles designed to produce spread-out-Bragg peaks ranging in size from 2 to 16 g/cm{sup 2}. Field sizes of up to 25x25 cm{sup 2} can be achieved with the double scattering system. The IMPT delivery technique is discrete spot scanning, which has a maximum field size of 30x30 cm{sup 2}. Depth scanning is achieved by changing the energy

  5. Modern Radiation Therapy for Extranodal Lymphomas: Field and Dose Guidelines From the International Lymphoma Radiation Oncology Group

    SciTech Connect

    Yahalom, Joachim; Illidge, Tim; Specht, Lena; Hoppe, Richard T.; Li, Ye-Xiong; Tsang, Richard; Wirth, Andrew

    2015-05-01

    Extranodal lymphomas (ENLs) comprise about a third of all non-Hodgkin lymphomas (NHL). Radiation therapy (RT) is frequently used as either primary therapy (particularly for indolent ENL), consolidation after systemic therapy, salvage treatment, or palliation. The wide range of presentations of ENL, involving any organ in the body and the spectrum of histological sub-types, poses a challenge both for routine clinical care and for the conduct of prospective and retrospective studies. This has led to uncertainty and lack of consistency in RT approaches between centers and clinicians. Thus far there is a lack of guidelines for the use of RT in the management of ENL. This report presents an effort by the International Lymphoma Radiation Oncology Group (ILROG) to harmonize and standardize the principles of treatment of ENL, and to address the technical challenges of simulation, volume definition and treatment planning for the most frequently involved organs. Specifically, detailed recommendations for RT volumes are provided. We have applied the same modern principles of involved site radiation therapy as previously developed and published as guidelines for Hodgkin lymphoma and nodal NHL. We have adopted RT volume definitions based on the International Commission on Radiation Units and Measurements (ICRU), as has been widely adopted by the field of radiation oncology for solid tumors. Organ-specific recommendations take into account histological subtype, anatomy, the treatment intent, and other treatment modalities that may be have been used before RT.

  6. Radiation Therapy for Neovascular Age-related Macular Degeneration

    SciTech Connect

    Kishan, Amar U.; Modjtahedi, Bobeck S.; Morse, Lawrence S.; Lee, Percy

    2013-03-01

    In the enormity of the public health burden imposed by age-related macular degeneration (ARMD), much effort has been directed toward identifying effective and efficient treatments. Currently, anti-vascular endothelial growth factor (VEGF) injections have demonstrated considerably efficacy in treating neovascular ARMD, but patients require frequent treatment to fully benefit. Here, we review the rationale and evidence for radiation therapy of ARMD. The results of early photon external beam radiation therapy are included to provide a framework for the sequential discussion of evidence for the usage of stereotactic radiation therapy, proton therapy, and brachytherapy. The evidence suggests that these 3 modern modalities can provide a dose-dependent benefit in the treatment of ARMD. Most importantly, preliminary data suggest that all 3 can be used in conjunction with anti-VEGF therapeutics, thereby reducing the frequency of anti-VEGF injections required to maintain visual acuity.

  7. Hanford Lifecycle Reports - Hanford Site

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Hanford Lifecycle Reports Hanford Lifecycle Reports Hanford Lifecycle Reports Hanford Lifecycle Reports Email Email Page | Print Print Page | Text Increase Font Size Decrease Font Size 2016 Hanford Lifecycle Report 2015 Hanford Lifecycle Report 2014 Hanford Lifecycle Report 2013 Hanford Lifecycle Report 2012 Hanford Lifecycle Report 2011 Hanford Lifecycle Report Share on Last Updated 02/22/2016 2:54

  8. Shape memory polymer foams for endovascular therapies (Patent) | DOEPatents

    Office of Scientific and Technical Information (OSTI)

    polymer foams for endovascular therapies Title: Shape memory polymer foams for endovascular therapies A system for occluding a physical anomaly. One embodiment comprises a shape memory material body wherein the shape memory material body fits within the physical anomaly occluding the physical anomaly. The shape memory material body has a primary shape for occluding the physical anomaly and a secondary shape for being positioned in the physical anomaly. Inventors: Wilson, Thomas S. ; Maitland,

  9. 2008 Annual Report

    SciTech Connect

    2008-01-01

    This annual report includes: a brief overview of Western; FY 2008 operational highlights; and financial data.

  10. CAF Bug Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    » CAF Bug Reports CAF Bug Reports There are currently no significant reported user bugs with CAF. November 18, 2013 No reported CAF bugs. Read the full post Subscribe via RSS Subscribe Browse by Date November 2013 Last edited: 2016-04-29 11:34:54

  11. Audit Report: IG-0651

    Office of Energy Efficiency and Renewable Energy (EERE)

    Audit Report on Management of the Department's Personnel Security and Access Control Information Systems

  12. STEP Program Benchmark Report

    Energy.gov [DOE]

    STEP Program Benchmark Report, from the Tool Kit Framework: Small Town University Energy Program (STEP).

  13. STEP Participant Survey Report

    Office of Energy Efficiency and Renewable Energy (EERE)

    STEP Participant Survey Report, from the Tool Kit Framework: Small Town University Energy Program (STEP).

  14. Quarterly Progress Report

    Energy.gov [DOE]

    Quarterly Progress Report, from the Tool Kit Framework: Small Town University Energy Program (STEP).

  15. Radiation Therapy to the Plexus Brachialis in Breast Cancer Patients: Analysis of Paresthesia in Relation to Dose and Volume

    SciTech Connect

    Lundstedt, Dan; Gustafsson, Magnus; Steineck, Gunnar; Sundberg, Agnetha; Wilderäng, Ulrica; Holmberg, Erik; Johansson, Karl-Axel; Karlsson, Per

    2015-06-01

    Purpose: To identify volume and dose predictors of paresthesia after irradiation of the brachial plexus among women treated for breast cancer. Methods and Materials: The women had breast surgery with axillary dissection, followed by radiation therapy with (n=192) or without irradiation (n=509) of the supraclavicular lymph nodes (SCLNs). The breast area was treated to 50 Gy in 2.0-Gy fractions, and 192 of the women also had 46 to 50 Gy to the SCLNs. We delineated the brachial plexus on 3-dimensional dose-planning computerized tomography. Three to eight years after radiation therapy the women answered a questionnaire. Irradiated volumes and doses were calculated and related to the occurrence of paresthesia in the hand. Results: After treatment with axillary dissection with radiation therapy to the SCLNs 20% of the women reported paresthesia, compared with 13% after axillary dissection without radiation therapy, resulting in a relative risk (RR) of 1.47 (95% confidence interval [CI] 1.02-2.11). Paresthesia was reported by 25% after radiation therapy to the SCLNs with a V{sub 40} {sub Gy} ≥ 13.5 cm{sup 3}, compared with 13% without radiation therapy, RR 1.83 (95% CI 1.13-2.95). Women having a maximum dose to the brachial plexus of ≥55.0 Gy had a 25% occurrence of paresthesia, with RR 1.86 (95% CI 0.68-5.07, not significant). Conclusion: Our results indicate that there is a correlation between larger irradiated volumes of the brachial plexus and an increased risk of reported paresthesia among women treated for breast cancer.

  16. Radiation-induced prostatic sarcoma: A case report

    SciTech Connect

    Scully, J.M.; Uno, J.M.; McIntyre, M.; Mosely, S. )

    1990-09-01

    A 64-year-old man had a prostatic sarcoma 8 years after transurethral prostatectomy and radical bilateral pelvic lymph node dissection with insertion of 125-iodine implants for stage B1N carcinoma of the prostate. Therapy for the sarcoma consisted of isolated pelvic perfusion and then pelvic exenteration with creation of an ileal conduit and colostomy. The pathology report showed well encapsulated grade 2 spindle cell sarcoma of the prostate. Multiple small metallic particles were embedded in the tumor specimen.

  17. NERSC Annual Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    NERSC Annual Reports NERSC Annual Reports Sort by: Default | Name anrep2000.png NERSC Annual Report 2000 Download Image: anrep2000.png | png | 203 KB Download File: NERSCAnnualReport2000.pdf | pdf | 4.9 MB anrep2001.png NERSC Annual Report 2001 Download Image: anrep2001.png | png | 175 KB Download File: annrep01.pdf | pdf | 7.1 MB anrep2002.png NERSC Annual Report 2002 Download Image: anrep2002.png | png | 55 KB Download File: annrep02.pdf | pdf | 3.4 MB anrep2003.png NERSC Annual Report 2003

  18. Publications & Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    User Surveys HPC Requirements for Science HPC Workshop Reports NERSC Staff Publications & Presentations Journal Cover Stories Galleries facebook icon Facebook google plus icon Google+ twitter icon Twitter Home » News & Publications » Publications & Reports Publications & Reports » Download the NERSC Strategic Plan (PDF | 3.2 MB) NERSC Annual Reports NERSC's annual reports highlight the scientific accomplishments of its users and innovations of its staff. Read More » Science

  19. Annual Site Environmental Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    2014 Annual Site Environmental Report Updated July 24, 2015 NETL's Annual Site Environmental Report for 2014 -ii- 2014 Annual Site Environmental Report September 9, 2015 U.S. Department of Energy National Energy Technology Laboratory Albany, Oregon Anchorage, Alaska Morgantown, West Virginia Pittsburgh, Pennsylvania Sugar Land, Texas NETL's Annual Site Environmental Report for 2014 -iii- Disclaimer This report was prepared as an account of work sponsored by an agency of the U.S. Government.

  20. Technical Consultant Report Template

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    TECHNICAL CONSULTING REPORT Page 1 of 1 Report Date Report By: Homeowner Address Consult Type & Date(s) Email / Telephone In Person Purpose(s) of Meeting (generally) Service(s) Undertaken Observations Recommendations a. Visual Inspection Attic Basement / Crawlspace Equipment Other b. Diagnostic Testing Blower Door Combustion Testing Other c. Written Materials Review Audit Report Proposal Other d. Other NOTE: This Report was prepared at the request of the Homeowner, based on information

  1. Prospective Study of Local Control and Late Radiation Toxicity After Intraoperative Radiation Therapy Boost for Early Breast Cancer

    SciTech Connect

    Chang, David W.; Marvelde, Luc te; Chua, Boon H.

    2014-01-01

    Purpose: To report the local recurrence rate and late toxicity of intraoperative radiation therapy (IORT) boost to the tumor bed using the Intrabeam System followed by external-beam whole-breast irradiation (WBI) in women with early-stage breast cancer in a prospective single-institution study. Methods and Materials: Women with breast cancer ?3 cm were recruited between February 2003 and May 2005. After breast-conserving surgery, a single dose of 5 Gy IORT boost was delivered using 50-kV x-rays to a depth of 10 mm from the applicator surface. This was followed by WBI to a total dose of 50 Gy in 25 fractions. Patients were reviewed at regular, predefined intervals. Late toxicities were recorded using the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer Late Radiation Morbidity Scoring systems. Results: Fifty-five patients completed both IORT boost and external-beam WBI. Median follow-up was 3.3 years (range, 1.4-4.1 years). There was no reported locoregional recurrence or death. One patient developed distant metastases. Grade 2 and 3 subcutaneous fibrosis was detected in 29 (53%) and 8 patients (15%), respectively. Conclusions: The use of IORT as a tumor bed boost using kV x-rays in breast-conserving therapy was associated with good local control but a clinically significant rate of grade 2 and 3 subcutaneous fibrosis.

  2. Annual Reports | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Annual Reports Annual Reports Note: Some of the following documents are in PDF and will require Adobe Reader for viewing. Freedom of Information Act Annual Reports Annual Report for 2015 Annual Report for 2014 Annual Report for 2013 Annual Report for 2012 Annual Report for 2011 Annual Report for 2010 Annual Report for 2009 Annual Report for 2008 (pdf) Annual Report for 2007 (pdf) Annual Report for 2006 (pdf) Annual Report for 2005 (pdf) Annual Report for 2004 (pdf) Annual Report for 2003 (pdf)

  3. Quality of Life and Toxicity From Passively Scattered and Spot-Scanning Proton Beam Therapy for Localized Prostate Cancer

    SciTech Connect

    Pugh, Thomas J. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Munsell, Mark F. [Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Choi, Seungtaek; Nguyen, Quyhn Nhu; Mathai, Benson [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Zhu, X. Ron; Sahoo, Narayan; Gillin, Michael; Johnson, Jennifer L.; Amos, Richard A. [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Dong, Lei [Scripps Proton Therapy Center, San Diego, California (United States); Mahmood, Usama; Kuban, Deborah A.; Frank, Steven J.; Hoffman, Karen E.; McGuire, Sean E. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Lee, Andrew K., E-mail: aklee@mdanderson.org [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2013-12-01

    Purpose: To report quality of life (QOL)/toxicity in men treated with proton beam therapy for localized prostate cancer and to compare outcomes between passively scattered proton therapy (PSPT) and spot-scanning proton therapy (SSPT). Methods and Materials: Men with localized prostate cancer enrolled on a prospective QOL protocol with a minimum of 2 years' follow-up were reviewed. Comparative groups were defined by technique (PSPT vs SSPT). Patients completed Expanded Prostate Cancer Index Composite questionnaires at baseline and every 3-6 months after proton beam therapy. Clinically meaningful differences in QOL were defined as ?0.5 baseline standard deviation. The cumulative incidence of modified Radiation Therapy Oncology Group grade ?2 gastrointestinal (GI) or genitourinary (GU) toxicity and argon plasma coagulation were determined by the Kaplan-Meier method. Results: A total of 226 men received PSPT, and 65 received SSPT. Both PSPT and SSPT resulted in statistically significant changes in sexual, urinary, and bowel Expanded Prostate Cancer Index Composite summary scores. Only bowel summary, function, and bother resulted in clinically meaningful decrements beyond treatment completion. The decrement in bowel QOL persisted through 24-month follow-up. Cumulative grade ?2 GU and GI toxicity at 24 months were 13.4% and 9.6%, respectively. There was 1 grade 3 GI toxicity (PSPT group) and no other grade ?3 GI or GU toxicity. Argon plasma coagulation application was infrequent (PSPT 4.4% vs SSPT 1.5%; P=.21). No statistically significant differences were appreciated between PSPT and SSPT regarding toxicity or QOL. Conclusion: Both PSPT and SSPT confer low rates of grade ?2 GI or GU toxicity, with preservation of meaningful sexual and urinary QOL at 24 months. A modest, yet clinically meaningful, decrement in bowel QOL was seen throughout follow-up. No toxicity or QOL differences between PSPT and SSPT were identified. Long-term comparative results in a larger patient

  4. Data Network Weather Service Reporting - Final Report

    SciTech Connect

    Michael Frey

    2012-08-30

    A final report is made of a three-year effort to develop a new forecasting paradigm for computer network performance. This effort was made in co-ordination with Fermi Lab's construction of e-Weather Center.

  5. Microsoft Word - Blue Report Cover Report

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Report on Critical Asset Vulnerability and Risk Assessments at the Power Marketing Administrations--Follow- up Audit DOE/IG-0842 October 2010 Department of Energy Washington, DC 20585 October 7, 2010 MEMORANDUM FOR THE ADMINISTRATORS, BONNEVILLE POWER, WESTERN AREA POWER, AND SOUTHWESTERN POWER ADMINISTRATIONS FROM: Gregory H. Friedman Inspector General SUBJECT: INFORMATION: Audit Report on "Critical Asset Vulnerability and Risk Assessment at the Power Marketing Administrations--Follow-up

  6. 1995 PVUSA progress report. Final report

    SciTech Connect

    1996-03-01

    Photovoltaics for Utility Scale Applications (PVUSA) is a national public-private partnership that is assessing and demonstrating the viability of utility-scale (US) photovoltaic (PV) electric generation systems and recent developments in PV module technology. This report updates the project`s progress, reviews the status and performance of the various PV installations during 1995, summarizes key accomplishments and conclusions, and serves as the final report under Pacific Gas and Electric Company`s project management.

  7. 2016 SSL Forecast Report

    Energy.gov [DOE]

    The DOE report, Energy Savings Forecast of Solid-State Lighting in General Illumination Applications, is a biannual report which models the adoption of LEDs in the U.S. general-lighting market,...

  8. "Annual Coal Report

    Energy Information Administration (EIA) (indexed site)

    Annual Coal Report Data Released: January 20, 2015 Data for: 2013 Re-Release Date: April 23, 2015 (CORRECTION) Annual Coal Report 2013 CorrectionUpdate April 23, 2015 The Annual ...

  9. SSL Forecast Report

    Energy.gov [DOE]

    The DOE report, Energy Savings Forecast of Solid-State Lighting in General Illumination Applications, is the latest edition of a biannual report which models the adoption of LEDs in the U.S....

  10. Quarterly Progress Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Effective Recovery of Low-TDS Frac Flowback Water for Re-use Department of Energy: DE-FE0000784 Final Report Reporting Period: October 1, 2009 - March 31, 2011 Harish R. Acharya...

  11. Monthly Performance Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    3 Monthly Performance Report December 2014 F. Armijo President and General Manager U.S. Department of Energy Contract DE-AC06-09RL14728 MSC Monthly Performance Report DEC 2014 DOE...

  12. Capital Reporting Company Quadrennial ...

    Energy.gov [DOE] (indexed site)

    Capital Reporting Company Quadrennial Energy Review Meeting No. 4 06-19-2014 (866) 448 - DEPO www.CapitalReportingCompany.com 2014 1 UNITED STATES DEPARTMENT OF ENERGY OFFICE OF ...

  13. Biochemical Response to Androgen Deprivation Therapy Before External Beam Radiation Therapy Predicts Long-term Prostate Cancer Survival Outcomes

    SciTech Connect

    Zelefsky, Michael J.; Gomez, Daniel R.; Polkinghorn, William R.; Pei, Xin; Kollmeier, Marisa

    2013-07-01

    Purpose: To determine whether the response to neoadjuvant androgen deprivation therapy (ADT) defined by a decline in prostate-specific antigen (PSA) to nadir values is associated with improved survival outcomes after external beam radiation therapy (EBRT) for prostate cancer. Methods and Materials: One thousand forty-five patients with localized prostate cancer were treated with definitive EBRT in conjunction with neoadjuvant and concurrent ADT. A 6-month course of ADT was used (3 months during the neoadjuvant phase and 2 to 3 months concurrently with EBRT). The median EBRT prescription dose was 81 Gy using a conformal-based technique. The median follow-up time was 8.5 years. Results: The 10-year PSA relapse-free survival outcome among patients with pre-radiation therapy PSA nadirs of ?0.3 ng/mL was 74.3%, compared with 57.7% for patients with higher PSA nadir values (P<.001). The 10-year distant metastases-free survival outcome among patients with pre-radiation therapy PSA nadirs of ?0.3 ng/mL was 86.1%, compared with 78.6% for patients with higher PSA nadir values (P=.004). In a competing-risk analysis, prostate cancer-related deaths were also significantly reduced among patients with pre-radiation therapy PSA nadirs of <0.3 ng/mL compared with higher values (7.8% compared with 13.7%; P=.009). Multivariable analysis demonstrated that the pre-EBRT PSA nadir value was a significant predictor of long-term biochemical tumor control, distant metastases-free survival, and cause-specific survival outcomes. Conclusions: Pre-radiation therapy nadir PSA values of ?0.3 ng/mL after neoadjuvant ADT were associated with improved long-term biochemical tumor control, reduction in distant metastases, and prostate cancer-related death. Patients with higher nadir values may require alternative adjuvant therapies to improve outcomes.

  14. The Efficacy of Radiation Therapy in the Treatment of Graves' Orbitopathy

    SciTech Connect

    Matthiesen, Chance; Thompson, J. Spencer; Thompson, David; Farris, Bradley; Wilkes, Byron; Ahmad, Salahuddin; Herman, Terence; Bogardus, Carl

    2012-01-01

    Purpose: To review our institutional outcomes of patients treated with radiation therapy (RT) for Graves' orbitopathy (GO), assess the role of orbital reirradiation, and identify prognostic factors of complete response (CR). Methods and Materials: This is a retrospective review of 211 patients who presented with a diagnosis of GO and received RT between January 2000-2010. RT dose was 20 Gy in 10 fractions. Patient median age was 51 years (range, 15-84 years), median follow-up was 11 months (range, 1-88 months). Patient symptoms included any combination of proptosis (90.9%), extraocular muscle dysfunction (78.9%), soft tissue signs (68.4%), and diplopia (58.4%). Corticosteroids were used as first-line therapy in 20.6% of patients. Among those who achieved either CR or partial response (PR), prognostic factors were evaluated. Results: Stabilization of disease without recurrence was clinically achieved overall in 202 patients (96.7%). At the completion of RT, 176 patients (84.2%) reported a symptomatic improvement of pretreatment symptoms. CR of GO symptoms was achieved using multiple treatment modalities, including RT by 93 patients (44.5%), of which 32 patients received RT only. Corticosteroids were discontinued in 97.8% of patients who received them as initial therapy. Surgical intervention following radiotherapy was required for 144 (68.9%) of all patients. Fourteen patients received orbital reirradiation for persistent or recurrent symptoms. Five of these achieved a CR, and the other nine achieved disease stabilization but retained persistent ocular symptoms. Long-term side effects of RT included dry eyes (12%). Of the prognostic factors we investigated, only gender predicted CR, which was less common in men (33.9%) than in women (49.7%) p = 0.0471. Conclusions: Orbital radiation for GO is an established treatment modality for patients. Orbital reirradiation is beneficial for patients who do not respond to initial RT or experience symptom recurrence without an

  15. MMCR Calibration Report

    SciTech Connect

    Mead, D

    2010-03-23

    Calibration report for the Millimeter Wavelength Cloud Radar performed for the ARM Climate Research Facility by ProSensing Inc.

  16. Monthly Performance Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... Priority List (RIPL), Regulatory Decision Document (RDD) Reporting, and Dashboards. ... Control for badging, securing tour guides and facility briefers, ordering ...

  17. Regional Efficiency Progress Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Expand Utility Resources News & Events Expand News & Events Skip navigation links Marketing Resources Reports, Publications, and Research Agricultural Commercial Consumer...

  18. Hazard Analysis Database report

    SciTech Connect

    Niemi, B.J.

    1997-08-12

    This document describes and defines the Hazard Analysis Database for the Tank Waste Remediation System Final Safety Analysis Report.

  19. CM modeling report

    SciTech Connect

    Vann, J.M., Fluor Daniel Hanford

    1997-02-07

    This report compiles TWRS configuration management pre- implementation assessments, categorizes findings, and highlights programs identified for improvement.

  20. Smart Grid System Report

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    August 2014 2014 Smart Grid System Report Report to Congress August 2014 United States Department of Energy Washington, DC 20585 Department of Energy | August 2014 THIS PAGE INTENTIONALLY LEFT BLANK 2014 Smart Grid System Report Department of Energy | August 2014 Message from the Assistant Secretary Office of Electricity Delivery and Energy Reliability I am pleased to present the 2014 Smart Grid System Report, which is intended to provide an update on the status of smart grid deployment

  1. Federal Financial Report

    Energy.gov [DOE]

    Federal Financial Report, as posted on the U.S. Department of Energy's Better Buildings Neighborhood Program website.

  2. Progress Report Template

    Energy.gov [DOE]

    Progress report template, as posted on the U.S. Department of Energy's Better Buildings Neighborhood Program website.

  3. Hazard analysis results report

    SciTech Connect

    Niemi, B.J., Westinghouse Hanford

    1996-09-30

    This document describes and defines the Hazard Analysis Results for the Tank Waste Remediation System Final Safety Analysis Report.

  4. Assorted Situation Reports

    Office of Energy Efficiency and Renewable Energy (EERE)

    The Office of Electricity Delivery and Energy Reliability issues public Situation Reports during large scale energy emergencies.

  5. Inspection Report: IG-0438

    Energy.gov [DOE]

    Inspection of Reporting at Oak Ridge of Potential Noncompliances With DOE Price-Anderson Amendments Act Implementing Rules

  6. Cray Bug Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Reports Cray Bug Reports Viewing entries posted in November 2013 Cray C/C++ predefined _RELEASE macro returns wrong value [updated] November 18, 2013 by Mike Stewart, NERSC USG Status: Reported to Cray as bug 797442, became documentation bug 805340. Read the full post Subscribe via RSS Subscribe Browse by Date November 2013 Last edited: 2016-04-29 11:34:26

  7. 2014 Site Environmental Report

    SciTech Connect

    Paquette, Douglas; Remien, Jason; Foley, Brian; Burke, John; Dorsch, William; Ratel, Karen; Howe, Robert; Welty, Tim; Williams, Jeffrey; Pohlpt, Peter; Lagattolla, Richard; Metz, Robert; Milligan, James; Lettieri, Lawrence

    2015-10-01

    BNL prepares an annual Site Environmental Report (SER) in accordance with DOE Order 231.1B, Environment, Safety and Health Reporting. The report is written to inform the public, regulators, employees, and other stakeholders of the Laboratory’s environmental performance during the calendar year in review.

  8. Organic solvent topical report

    SciTech Connect

    Cowley, W.L.

    1998-04-30

    This report is the technical basis for the accident and consequence analyses used in the Hanford Tank Farms Basis for Interim Operation. The report also contains the scientific and engineering information and reference material needed to understand the organic solvent safety issue. This report includes comments received from the Chemical Reactions Subcommittee of the Tank Advisory Panel.

  9. Cray Bug Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Cray » Cray Bug Reports Cray Bug Reports Cray C/C++ predefined _RELEASE macro returns wrong value [updated] November 18, 2013 by Mike Stewart, NERSC USG Status: Reported to Cray as bug 797442, became documentation bug 805340. Read the full post Subscribe via RSS Subscribe Browse by Date November 2013 Last edited: 2016-04-29 11:34:26

  10. Technical Review Panel Report

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    TRP Report v7, 12 Aug 2012 TRP Report Final December 2012 Advanced Reactor Concepts Technical Review Panel Report Evaluation and Identification of future R&D on eight Advanced Reactor Concepts, conducted April - September 2012 December 2012 Public release version 2 Public release version 3 Table of Contents Summary ................................................................................................................................... 4 1. Overview of the Technical Review Panel

  11. Environmental Management Performance Reports - Hanford Site

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Impact Statements Environmental Management Performance Reports FY 2016 Reports FY 2015 Reports FY 2014 Reports FY 2013 Reports FY 2012 Reports FY 2011 Reports FY 2010 ...

  12. WE-D-BRD-01: Innovation in Radiation Therapy Delivery: Advanced Digital Linac Features

    SciTech Connect

    Xing, L; Wong, J; Li, R

    2014-06-15

    Last few years has witnessed significant advances in linac technology and therapeutic dose delivery method. Digital linacs equipped with high dose rate FFF beams have been clinically implemented in a number of hospitals. Gated VMAT is becoming increasingly popular in treating tumors affected by respiratory motion. This session is devoted to update the audience with these technical advances and to present our experience in clinically implementing the new linacs and dose delivery methods. Topics to be covered include, technical features of new generation of linacs from different vendors, dosimetric characteristics and clinical need for FFF-beam based IMRT and VMAT, respiration-gated VMAT, the concept and implementation of station parameter optimized radiation therapy (SPORT), beam level imaging and onboard image guidance tools. Emphasis will be on providing fundamental understanding of the new treatment delivery and image guidance strategies, control systems, and the associated dosimetric characteristics. Commissioning and acceptance experience on these new treatment delivery technologies will be reported. Clinical experience and challenges encountered during the process of implementation of the new treatment techniques and future applications of the systems will also be highlighted. Learning Objectives: Present background knowledge of emerging digital linacs and summarize their key geometric and dosimetric features. SPORT as an emerging radiation therapy modality specifically designed to take advantage of digital linacs. Discuss issues related to the acceptance and commissioning of the digital linacs and FFF beams. Describe clinical utility of the new generation of digital linacs and their future applications.

  13. Report number codes

    SciTech Connect

    Nelson, R.N.

    1985-05-01

    This publication lists all report number codes processed by the Office of Scientific and Technical Information. The report codes are substantially based on the American National Standards Institute, Standard Technical Report Number (STRN)-Format and Creation Z39.23-1983. The Standard Technical Report Number (STRN) provides one of the primary methods of identifying a specific technical report. The STRN consists of two parts: The report code and the sequential number. The report code identifies the issuing organization, a specific program, or a type of document. The sequential number, which is assigned in sequence by each report issuing entity, is not included in this publication. Part I of this compilation is alphabetized by report codes followed by issuing installations. Part II lists the issuing organization followed by the assigned report code(s). In both Parts I and II, the names of issuing organizations appear for the most part in the form used at the time the reports were issued. However, for some of the more prolific installations which have had name changes, all entries have been merged under the current name.

  14. A Novel Precise Proton Range Diagnostic for Proton Therapy Treatment |

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Princeton Plasma Physics Lab A Novel Precise Proton Range Diagnostic for Proton Therapy Treatment Unlike conventional x-ray radiotherapy that uses x-ray photons to propagate through the tissue and kill tumor cells, proton therapy is an advanced treatment that uses high-energy protons. While x-ray photons deposit their energy in a continuous fashion along their travel in tissue, energetic protons deposit most of their energy at the location where they stop (i.e., tumor cells), minimizing the

  15. June 2015 Most Viewed Documents for Biology And Medicine | OSTI, US Dept of

    Office of Scientific and Technical Information (OSTI)

    Energy Office of Scientific and Technical Information June 2015 Most Viewed Documents for Biology And Medicine Measuring dopamine release in the human brain with PET Volkow, N.D. [Brookhaven National Lab., Upton, NY (United States)]|[State Univ. of New York at Stony Brook, Stony Brook, NY (United States). Dept. of Psychiatry]; Fowler, J.S.; Logan, J.; Wang, G.J. [Brookhaven National Lab., Upton, NY (United States)] (1995) 115 Dose and volume specification for reporting interstitial therapy

  16. March 2014 Most Viewed Documents for Biology And Medicine | OSTI, US Dept

    Office of Scientific and Technical Information (OSTI)

    of Energy Office of Scientific and Technical Information March 2014 Most Viewed Documents for Biology And Medicine Carbon Dioxide Sequestering Using Microalgal Systems Daniel J. Stepan; Richard E. Shockey; Thomas A. Moe; Ryan Dorn (2002) 30 Dose and volume specification for reporting interstitial therapy NONE (1997) 29 Geothermal demonstration: Zunil food dehydration facility Maldonado, O. (Consultecnia, Guatemala City (Guatemala)); Altseimer, J.; Thayer, G.R. (Los Alamos National Lab., NM

  17. Most Viewed Documents for Biology and Medicine: December 2014 | OSTI, US

    Office of Scientific and Technical Information (OSTI)

    Dept of Energy Office of Scientific and Technical Information Most Viewed Documents for Biology and Medicine: December 2014 Dose and volume specification for reporting interstitial therapy NONE (1997) 38 Modification to the Monte Carlo N-Particle (MCNP) Visual Editor (MCNPVised) to Read in Computer Aided Design (CAD) Files Randolph Schwarz; Leland L. Carter; Alysia Schwarz (2005) 38 Drug Retention Times Center for Human Reliability Studies (2007) 34 Degradation of high concentrations of

  18. Most Viewed Documents for Biology and Medicine: September 2014 | OSTI, US

    Office of Scientific and Technical Information (OSTI)

    Dept of Energy Office of Scientific and Technical Information for Biology and Medicine: September 2014 Modification to the Monte Carlo N-Particle (MCNP) Visual Editor (MCNPVised) to Read in Computer Aided Design (CAD) Files Randolph Schwarz; Leland L. Carter; Alysia Schwarz (2005) 32 Dose and volume specification for reporting interstitial therapy NONE (1997) 28 Carbon Dioxide Sequestering Using Microalgal Systems Daniel J. Stepan; Richard E. Shockey; Thomas A. Moe; Ryan Dorn (2002) 27 Drug

  19. 2014 Better Buildings Neighborhood Program Reporting Calendar

    Energy.gov [DOE]

    Better Buildings Neighborhood Program, reporting, grants, quarterly report, recovery act report, davis-bacon report, historic preservation report, pmc

  20. A Dosimetric Comparison of Tomotherapy and Volumetric Modulated Arc Therapy in the Treatment of High-Risk Prostate Cancer With Pelvic Nodal Radiation Therapy

    SciTech Connect

    Pasquier, David; Cavillon, Fabrice; Lacornerie, Thomas; Touzeau, Claire; Tresch, Emmanuelle; Lartigau, Eric

    2013-02-01

    Purpose: To compare the dosimetric results of volumetric modulated arc therapy (VMAT) and helical tomotherapy (HT) in the treatment of high-risk prostate cancer with pelvic nodal radiation therapy. Methods and Materials: Plans were generated for 10 consecutive patients treated for high-risk prostate cancer with prophylactic whole pelvic radiation therapy (WPRT) using VMAT and HT. After WPRT, a sequential boost was delivered to the prostate. Plan quality was assessed according to the criteria of the International Commission on Radiation Units and Measurements 83 report: the near-minimal (D98%), near-maximal (D2%), and median (D50%) doses; the homogeneity index (HI); and the Dice similarity coefficient (DSC). Beam-on time, integral dose, and several organs at risk (OAR) dosimetric indexes were also compared. Results: For WPRT, HT was able to provide a higher D98% than VMAT (44.3 {+-} 0.3 Gy and 43.9 {+-} 0.5 Gy, respectively; P=.032) and a lower D2% than VMAT (47.3 {+-} 0.3 Gy and 49.1 {+-} 0.7 Gy, respectively; P=.005), leading to a better HI. The DSC was better for WPRT with HT (0.89 {+-} 0.009) than with VMAT (0.80 {+-} 0.02; P=.002). The dosimetric indexes for the prostate boost did not differ significantly. VMAT provided better rectum wall sparing at higher doses (V70, V75, D2%). Conversely, HT provided better bladder wall sparing (V50, V60, V70), except at lower doses (V20). The beam-on times for WPRT and prostate boost were shorter with VMAT than with HT (3.1 {+-} 0.1 vs 7.4 {+-} 0.6 min, respectively; P=.002, and 1.5 {+-} 0.05 vs 3.7 {+-} 0.3 min, respectively; P=.002). The integral dose was slightly lower for VMAT. Conclusion: VMAT and HT provided very similar and highly conformal plans that complied well with OAR dose-volume constraints. Although some dosimetric differences were statistically significant, they remained small. HT provided a more homogeneous dose distribution, whereas VMAT enabled a shorter delivery time.

  1. Nuclear proliferation status report. Status report

    SciTech Connect

    1992-07-01

    This report contains information concerning the nuclear proliferation status of the following countries: (1) Russia, (2) Ukraine, (3) Belarus, (4) Kazakhstan, (5) Israel, (6) India, (7) Pakistan, (8) South Africa, (9) North Korea, (10) Iraq, (11) Iran, (12) Lybia, (13) Algeria, (14) Syria, (15) Brazil, (16) Argentina, and (17) Taiwan.

  2. Radiotherapy Quality Assurance Report From Children's Oncology Group AHOD0031

    SciTech Connect

    Dharmarajan, Kavita V.; Friedman, Debra L.; FitzGerald, T.J.; McCarten, Kathleen M.; Chen, Lu; Kessel, Sandy K.; Iandoli, Matt; Laurie, Fran; Schwartz, Cindy L.; Wolden, Suzanne L.

    2015-04-01

    Purpose: A phase 3 trial assessing response-based therapy in intermediate-risk Hodgkin lymphoma mandated real-time central review of involved field radiation therapy (IFRT) and imaging records by a centralized review center to maximize protocol compliance. We report the impact of centralized radiation therapy review on protocol compliance. Methods and Materials: Review of simulation films, port films, and dosimetry records was required before and after treatment. Records were reviewed by study-affiliated or review center–affiliated radiation oncologists. A deviation of 6% to 10% from protocol-specified dose was scored as “minor”; a deviation of >10% was “major.” A volume deviation was scored as “minor” if margins were less than specified or “major” if fields transected disease-bearing areas. Interventional review and final compliance review scores were assigned to each radiation therapy case and compared. Results: Of 1712 patients enrolled, 1173 underwent IFRT at 256 institutions in 7 countries. An interventional review was performed in 88% of patients and a final review in 98%. Overall, minor and major deviations were found in 12% and 6% of patients, respectively. Among the cases for which ≥1 pre-IFRT modification was requested by the Quality Assurance Review Center and subsequently made by the treating institution, 100% were made compliant on final review. By contrast, among the cases for which ≥1 modification was requested but not made by the treating institution, 10% were deemed compliant on final review. Conclusions: In a large trial with complex treatment pathways and heterogeneous radiation therapy fields, central review was performed in a large percentage of cases before IFRT and identified frequent potential deviations in a timely manner. When suggested modifications were performed by the institutions, deviations were almost eliminated.

  3. Dynamic materials testing and constitutive modeling of structural sheet steel for automotive applications. Final progress report

    SciTech Connect

    Cady, C.M.; Chen, S.R.; Gray, G.T. III

    1996-08-23

    The objective of this study was to characterize the dynamic mechanical properties of four different structural sheet steels used in automobile manufacture. The analysis of a drawing quality, special killed (DQSK) mild steel; high strength, low alloy (HSLA) steel; interstitial free (IF); and a high strength steel (M-190) have been completed. In addition to the true stress-true strain data, coefficients for the Johnson-Cook, Zerilli-Armstrong, and Mechanical Threshold Stress constitutive models have been determined from the mechanical test results at various strain rates and temperatures and are summarized. Compression, tensile, and biaxial bulge tests and low (below 0.1/s) strain rate tests were completed for all four steels. From these test results it was determined to proceed with the material modeling optimization using the through thickness compression results. Compression tests at higher strain rates and temperatures were also conducted and analyzed for all the steels. Constitutive model fits were generated from the experimental data. This report provides a compilation of information generated from mechanical tests, the fitting parameters for each of the constitutive models, and an index and description of data files.

  4. 2009 Site Environmental Report

    SciTech Connect

    Ratel, K.M.; Brookhaven National Laboratory

    2010-09-30

    Each year, Brookhaven National Laboratory (BNL) prepares an annual Site Environmental Report (SER) in accordance with DOE Order 231.1A, Environment, Safety and Health Reporting of the U.S. Department of Energy. The report is written to inform the public, regulators, employees, and other stakeholders of BNL's environmental performance during the calendar year in review. The SER summarizes environmental data; environmental management performance; compliance with applicable DOE, federal, state, and local regulations; and compliance, restoration, and surveillance monitoring program performance. BNL has prepared annual SERs since 1971 and has documented nearly all of its environmental history since the Laboratory's inception in 1947. The report is available in print and as a downloadable file on the BNL web page at http://www.bnl.gov/ewms/ser/. A summary of the SER is also prepared each year to provide a general overview of the report, and is distributed with a CD of the full report.

  5. LANSCE Activity Report

    SciTech Connect

    Amy Robinson; Audrey Archuleta; Barbara Maes; Dan Strottman; Earl Hoffman; Garth Tietjen; Gene Farnum; Geoff Greene; Joyce Roberts; Ken Johnson; Paul Lewis; Roger Pynn; Stan Schriber; Steve Sterbenz; Steve Wender; Sue Harper

    1999-02-01

    The Los Alamos Neutron Science Center Activity Report describes scientific and technological progress and achievements in LANSCE Division during the period of 1995 to 1998. This report includes a message from the Division Director, an overview of LANSCE, sponsor overviews, research highlights, advanced projects and facility upgrades achievements, experimental and user program accomplishments, news and events, and a list of publications. The research highlights cover the areas of condensed-matter science and engineering, accelerator science, nuclear science, and radiography. This report also contains a compact disk that includes an overview, the Activity Report itself, LANSCE operations progress reports for 1996 and 1997, experiment reports from LANSCE users, as well as a search capability.

  6. 2005 SITE ENVIRONMENTAL REPORT

    SciTech Connect

    BROOKHAVEN NATIONAL LABORATORY

    2006-08-29

    Each year, Brookhaven National Laboratory (BNL) prepares an annual Site Environmental Report (SER) in accordance with DOE Order 231.1A, Environment, Safety and Health Reporting of the U.S. Department of Energy (DOE). The report is written to inform the public, regulators, employees, and other stakeholders of BNL's environmental performance during the calendar year in review. The SER summarizes environmental data; environmental management performance; compliance with applicable DOE, federal, state, and local regulations; and compliance, restoration, and surveillance monitoring program performance. BNL has prepared annual SERs since 1971 and has documented nearly all of its environmental history since the Laboratory's inception in 1947. The report is available in print and as a downloadable file on the BNL web page at http://www.bnl.gov/ewms/ser/. A summary of the SER is also prepared each year to provide a general overview of the report, and is distributed with a CD of the full report.

  7. 2006 SITE ENVIRONMENTAL REPORT

    SciTech Connect

    BROOKHAVEN NATIONAL LABORATORY; RATEL,K.

    2007-10-01

    Each year, Brookhaven National Laboratory (BNL) prepares an annual Site Environmental Report (SER) in accordance with DOE Order 231.1A, Environment, Safety and Health Reporting of the U.S. Department of Energy. The report is written to inform the public, regulators, employees, and other stakeholders of BNL's environmental performance during the calendar year in review. The SER summarizes environmental data; environmental management performance; compliance with applicable DOE, federal, state, and local regulations; and compliance, restoration, and surveillance monitoring program performance. BNL has prepared annual SERs since 1971 and has documented nearly all of its environmental history since the Laboratory's inception in 1947. The report is available in print and as a downloadable file on the BNL web page at http://www.bnl.gov/ewms/ser/. A summary of the SER is also prepared each year to provide a general overview of the report, and is distributed with a CD of the full report.

  8. Damaged Surface Hydrodynamics (DSH) Flash Report (Technical Report...

    Office of Scientific and Technical Information (OSTI)

    Technical Report: Damaged Surface Hydrodynamics (DSH) Flash Report Citation Details In-Document Search Title: Damaged Surface Hydrodynamics (DSH) Flash Report You are accessing ...

  9. FY09 Engineering Research & Technology Report (Technical Report...

    Office of Scientific and Technical Information (OSTI)

    Technical Report: FY09 Engineering Research & Technology Report Citation Details In-Document Search Title: FY09 Engineering Research & Technology Report Authors: Sharpe, R ; Pannu, ...

  10. MSC Monthly Performance Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    7 Monthly Performance Report August 2013 F. Armijo President and General Manager U.S. Department of Energy Contract DE-AC06-09RL14728 MSC Monthly Performance Report AUG 2013 DOE/RL-2009-113 Rev 47 ii This page intentionally left blank. CONTENTS MSC Monthly Performance Report AUG 2013 DOE/RL-2009-113 Rev 47 iii CONTENTS EXECUTIVE OVERVIEW 1.0 INTRODUCTION .................................................................................................................... 1 1.1 Key Accomplishments

  11. MSC Monthly Performance Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    3 Monthly Performance Report December 2009 F.A. Figueroa President and General Manager U.S. Department of Energy Contract DE-AC06-09RL14728 MSC Monthly Performance Report December 2009 DOE/RL-2009-113 REV 3 ii This page intentionally left blank. CONTENTS MSC Monthly Performance Report December 2009 DOE/RL-2009-113 REV 3 iii CONTENTS OVERVIEW 1.0 INTRODUCTION .................................................................................................................... 1 1.1 Key

  12. MSC Monthly Performance Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Monthly Performance Report November 2009 F.A. Figueroa President and General Manager U.S. Department of Energy Contract DE-AC06-09RL14728 MSC Monthly Performance Report November 2009 DOE/RL-2009-113 REV 2 ii This page intentionally left blank. CONTENTS MSC Monthly Performance Report November 2009 DOE/RL-2009-113 REV 2 iii CONTENTS OVERVIEW 1.0 INTRODUCTION .................................................................................................................... 1 1.1 Key

  13. MSC Monthly Performance Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    2 Monthly Performance Report July 2011 F. Armijo President and General Manager U.S. Department of Energy Contract DE-AC06-09RL14728 MSC Monthly Performance Report July 2011 DOE/RL-2009-113 REV 22 ii This page intentionally left blank. CONTENTS MSC Monthly Performance Report July 2011 DOE/RL-2009-113 REV 22 iii CONTENTS OVERVIEW 1.0 INTRODUCTION ......................................................................................................................... 1 1.1 Key Accomplishments

  14. MSC Monthly Performance Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    1 Monthly Performance Report June 2011 F. Armijo President and General Manager U.S. Department of Energy Contract DE-AC06-09RL14728 MSC Monthly Performance Report June 2011 DOE/RL-2009-113 REV 21 ii This page intentionally left blank. CONTENTS MSC Monthly Performance Report June 2011 DOE/RL-2009-113 REV 21 iii CONTENTS OVERVIEW 1.0 INTRODUCTION .................................................................................................................... 1 1.1 Key Accomplishments

  15. MSC Monthly Performance Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    8 Monthly Performance Report March 2011 F. Armijo President and General Manager U.S. Department of Energy Contract DE-AC06-09RL14728 MSC Monthly Performance Report March 2011 DOE/RL-2009-113 REV 18 ii This page intentionally left blank. CONTENTS MSC Monthly Performance Report March 2011 DOE/RL-2009-113 REV 18 iii CONTENTS OVERVIEW 1.0 INTRODUCTION .................................................................................................................... 1 1.1 Key Accomplishments

  16. MSC Monthly Performance Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    0 Monthly Performance Report May 2011 F. Armijo President and General Manager U.S. Department of Energy Contract DE-AC06-09RL14728 MSC Monthly Performance Report May 2011 DOE/RL-2009-113 REV 20 ii This page intentionally left blank. CONTENTS MSC Monthly Performance Report May 2011 DOE/RL-2009-113 REV 20 iii CONTENTS OVERVIEW 1.0 INTRODUCTION .................................................................................................................... 1 1.1 Key Accomplishments

  17. MSC Monthly Performance Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    6 Monthly Performance Report November 2011 F. Armijo President and General Manager U.S. Department of Energy Contract DE-AC06-09RL14728 MSC Monthly Performance Report Nov 2011 DOE/RL-2009-113 Rev 26 ii This page intentionally left blank. CONTENTS MSC Monthly Performance Report Nov 2011 DOE/RL-2009-113 Rev 26 iii CONTENTS EXECUTIVE OVERVIEW 1.0 INTRODUCTION .................................................................................................................... 1 1.1 Key

  18. 2012 Microgrid Workshop Report

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    2 DOE Microgrid Workshop July 30-31, 2012 Chicago, Illinois 2012 DOE Microgrid Workshop Report Page i Acknowledgment The U.S. Department of Energy (DOE) would like to acknowledge the support provided by the organizations represented on the workshop planning committee in developing the workshop process and sessions. The preparation of this workshop report was coordinated by Energy & Environmental Resources Group, LLC (E2RG). The report content is based on the workshop session discussions,

  19. Stakeholder Report on Stewardship

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    report was written and edited by members of the Stewardship Working Group with the assistance of Phoenix Environmental Corporation of Alexandria, Virginia & Bechtel Jacobs Company LLC Additional copies and information can be found on the DOE Oak Ridge Operations site on the world wide web: www.oakridge.doe.gov/em/ssab/Pubs.htm or by calling the Information Resource Center at 423-241-4582 Oak Ridge Reservation Stakeholder Report on Stewardship Volume 2 December 1999 Stakeholder Report on

  20. Monthly Performance Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    84 Monthly Performance Report September 2016 W. K. Johnson President U.S. Department of Energy Contract DE-AC06-09RL14728 MSC Monthly Performance Report SEPT 2016 DOE/RL-2009-113 Rev 84 ii This page intentionally left blank. CONTENTS MSC Monthly Performance Report SEPT 2016 DOE/RL-2009-113 Rev 84 iii CONTENTS EXECUTIVE OVERVIEW 1.0 INTRODUCTION .................................................................................................................... 1 1.1 Key Accomplishments

  1. UPC Bug Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Reports UPC Bug Reports Viewing entries posted in October 2014 Deadlock during first touch of upc_alloc'd remote memory when target is in upc_barrier [updated] October 16, 2014 Status: This has been reported to Cray (811537) and a workaround is available. Fixed in CCE 8.3.5. Read the full post Subscribe via RSS Subscribe Browse by Date October 2014 Last edited: 2016-04-29 11:34:42

  2. Section 1251 Report Update

    National Nuclear Security Administration (NNSA)

    November 2010 Update to the National Defense Authorization Act of FY2010 Section 1251 Report New START Treaty Framework and Nuclear Force Structure Plans 1. Introduction This paper updates elements of the report that was submitted to Congress on May 13, 2010, pursuant to section 1251 of the National Defense Authorization Act for Fiscal Year 2010 (Public Law 111-84) ("1251 Report"). 2. National Nuclear Security Administration and modernization of the complex - an overview From FY 2005

  3. Microsoft Word - Report Cover

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Audit Services Audit Report Status Report: The Department of Energy's State Energy Program Formula Grants Awarded under the American Recovery and Reinvestment Act OAS-RA-10-17 September 2010 Department of Energy Washington, DC 20585 September 21, 2010 MEMORANDUM FOR THE SECRETARY FROM: Gregory H. Friedman Inspector General SUBJECT: INFORMATION: "Status Report: The Department of Energy's State Energy Program Formula Grants Awarded under the American Recovery and Reinvestment Act"

  4. UPC Bug Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    » UPC Bug Reports UPC Bug Reports Deadlock during first touch of upc_alloc'd remote memory when target is in upc_barrier [updated] October 16, 2014 Status: This has been reported to Cray (811537) and a workaround is available. Fixed in CCE 8.3.5. Read the full post Subscribe via RSS Subscribe Browse by Date October 2014 Last edited: 2016-04-29 11:34:42

  5. SUMMARY INSPECTION REPORT

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    INSPECTION REPORT Alleged Fraud, Waste, Abuse and Mismanagement at a Department of Energy Site Office DOE/IG-0921* *An OUO Version of this report was issued under the same number September 2014 U.S. Department of Energy Office of Inspector General Office of Audits and Inspections Department of Energy Washington, DC 20585 September 30, 2014 MEMORANDUM FOR THE SECRETARY FROM: Gregory H. Friedman Inspector General SUBJECT: INFORMATION: Summary of Inspection Report on "Alleged Fraud, Waste,

  6. Tangible Personal Property Report

    Office of Energy Efficiency and Renewable Energy (EERE)

    This is a standard form to be used by awarding agencies to collect information related to tangible personal property (equipment and supplies) when required by a Federal financial assistance award. The form consists of the cover sheet (SF-428) and three attachments to be used as required: Annual Report, SF428-A; Final (Award Closeout) Report, SF-428-B; and a Disposition Request/Report, SF-428-C. A Supplemental Sheet, SF-428S, may be used to provide detailed individual item information.

  7. CAF Bug Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Research | Department of Energy CAB-Comm Final Report Documents Accomplishments from Six Years of Algal Research CAB-Comm Final Report Documents Accomplishments from Six Years of Algal Research May 10, 2016 - 5:40pm Addthis The Consortium for Algal Biofuel Commercialization (CAB-Comm), led by the University of California, San Diego, has just released its final report, detailing the many accomplishments and impactful contributions achieved in its six years of operation. CAB-Comm was

  8. Factors influencing radiation therapy student clinical placement satisfaction

    SciTech Connect

    Bridge, Pete; Carmichael, Mary-Ann

    2014-02-15

    Introduction: Radiation therapy students at Queensland University of Technology (QUT) attend clinical placements at five different clinical departments with varying resources and support strategies. This study aimed to determine the relative availability and perceived importance of different factors affecting student support while on clinical placement. The purpose of the research was to inform development of future support mechanisms to enhance radiation therapy students experience on clinical placement. Methods: This study used anonymous Likert-style surveys to gather data from years 1 and 2 radiation therapy students from QUT and clinical educators from Queensland relating to availability and importance of support mechanisms during clinical placements in a semester. Results: The study findings demonstrated student satisfaction with clinical support and suggested that level of support on placement influenced student employment choices. Staff support was perceived as more important than physical resources; particularly access to a named mentor, a clinical educator and weekly formative feedback. Both students and educators highlighted the impact of time pressures. Conclusions: The support offered to radiation therapy students by clinical staff is more highly valued than physical resources or models of placement support. Protected time and acknowledgement of the importance of clinical education roles are both invaluable. Joint investment in mentor support by both universities and clinical departments is crucial for facilitation of effective clinical learning.

  9. Proceedings of the first international symposium on neutron capture therapy

    SciTech Connect

    Fairchild, R.G.; Brownell, G.L.

    1982-01-01

    This meeting was arranged jointly by MIT and BNL in order to illuminate progress in the synthesis and targeting of boron compounds and to evaluate and document progress in radiobiological and dosimetric aspects of neutron capture therapy. It is hoped that this meeting will facilitate transfer of information between groups working in these fields, and encourage synergistic collaboration.

  10. Synchrotron Radiation Therapy from a Medical Physics point of view

    SciTech Connect

    Prezado, Y.; Berkvens, P.; Braeuer-Krisch, E.; Renier, M.; Bravin, A.; Adam, J. F.; Martinez-Rovira, I.; Fois, G.; Thengumpallil, S.; Edouard, M.; Deman, P.; Vautrin, M.

    2010-07-23

    Synchrotron radiation (SR) therapy is a promising alternative to treat brain tumors, whose management is limited due to the high morbidity of the surrounding healthy tissues. Several approaches are being explored by using SR at the European Synchrotron Radiation Facility (ESRF), where three techniques are under development Synchrotron Stereotactic Radiation Therapy (SSRT), Microbeam Radiation Therapy (MRT) and Minibeam Radiation Therapy (MBRT).The sucess of the preclinical studies on SSRT and MRT has paved the way to clinical trials currently in preparation at the ESRF. With this aim, different dosimetric aspects from both theoretical and experimental points of view have been assessed. In particular, the definition of safe irradiation protocols, the beam energy providing the best balance between tumor treatment and healthy tissue sparing in MRT and MBRT, the special dosimetric considerations for small field dosimetry, etc will be described. In addition, for the clinical trials, the definition of appropiate dosimetry protocols for patients according to the well established European Medical Physics recommendations will be discussed. Finally, the state of the art of the MBRT technical developments at the ESRF will be presented. In 2006 A. Dilmanian and collaborators proposed the use of thicker microbeams (0.36-0.68 mm). This new type of radiotherapy is the most recently implemented technique at the ESRF and it has been called MBRT. The main advantage of MBRT with respect to MRT is that it does not require high dose rates. Therefore it can be more easily applied and extended outside synchrotron sources in the future.

  11. TPO's Acceptance Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    TECHNICAL PROJECT OFFICER'S ACCEPTANCE REPORT DATE OF REQUEST: AWARD NUMBER: DE- AWARD PERIOD FROM: TO: NAME OF AWARDEE: PROJECT TITLE: OVERALL RATING OF AWARDEE'S PERFORMANCE ...

  12. WACR Calibration Report

    SciTech Connect

    Mead, D

    2010-03-23

    Calibration report for the W-Band (95 GHz) ARM Cloud Radar performed for the ARM Climate Research Facility by ProSensing Inc.

  13. 2001 SITE ENVIRONMENTAL REPORT

    SciTech Connect

    BROOKHAVEN NATIONAL LABORATORY

    2002-09-01

    THE SITE ENVIRONMENTAL REPORT FOR BROOKHAVEN NATIONAL LABORATORY FOR THE CALENDAR YEAR 2001, AS REQUIRED BY DOE ORDER 231.1.

  14. Weekly Petroleum Status Report

    Energy Information Administration (EIA) (indexed site)

    2 Appendix B Explanatory Notes and Detailed Methods Report 1. Overview .................................................................................................................................................................................................... 34 A. The Energy Information Administration's Quality Guidelines ............................................................................................................ 34 B. Concepts of Product Supply and Demand

  15. External Technical Review Report

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ... 34 Attachment F, ETR Report Format ... Readiness Review or Readiness Assessment ETRs are not required ... If a design technology, process, or system is new, ...

  16. Monthly Performance Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... ITD - PFM continues to develop a Regulatory Decision Document (RDD) reporting capability ... with existing policies, orders and guides, to enable DOE to determine whether an ...

  17. Monthly Performance Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... EXECUTIVE OVERVIEW MSC Monthly Performance Report JUN 2013 ... Optimization Assessment and PSRP Program Plan - MSA ... MSA Scholarship Reception - MSA Human Resources Services & ...

  18. International petroleum statistics report

    SciTech Connect

    1996-08-01

    This report provides information on current international petroleum production, demand, imports, and stocks. World oil demand and OECD demand data are presented for the years 1970 thru 1995.

  19. 1994 Site Environmental Report

    SciTech Connect

    1995-05-01

    The 1994 Site Environmental Report summarizes environmental activities at Lawrence Berkeley Laboratory (LBL) for the calendar year (CY) 1994. The report strives to present environmental data in a manner that characterizes the performance and compliance status of the Laboratory`s environmental management programs when measured against regulatory standards and DOE requirements. The report also discusses significant highlight and planning efforts of these programs. The format and content of the report are consistent with the requirements of the US Department of Energy (DOE) Order 5400.1, General Environmental Protection Program.

  20. Understanding LM-79 Reports

    SciTech Connect

    none,

    2012-03-01

    Solid-state lighting program technology fact sheet that discusses typical content of laboratory reports summarizing LM-79 test results for integrated SSL lamps and luminaires.

  1. Navigant Market Report 2014

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    this report, the authors thank the entire U.S. Department of Energy (DOE) Wind & Water Power Technologies Office, particularly Patrick Gilman and Michael Hahn. Navigant would also...

  2. Final Project Report

    SciTech Connect

    Wang, Qiang; Dandy, David S.

    2015-05-15

    This is the final technical report of the DOE project DE-FG02-07ER46448 awarded to Colorado State University.

  3. 1999 Site Environmental Report

    SciTech Connect

    2000-09-01

    The Site Environmental Report for Brookhaven National Laboratory for the calendar year 1999, as required by DOE Order 231.1.

  4. Monthly Performance Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... 2015 carryover work scope for inclusion in initial FY 2016 monthly performance reporting. ... FY 2016 unfunded work scope for consideration should additional funding become available. ...

  5. Monthly Performance Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... ACCOMPLISHMENTS Draft Hanford Lifecycle Scope, Schedule and Cost Report (Lifecycle ... Assumes implementation of FY 2012 Integrated Priority List (IPL) including carryover scope ...

  6. Monthly Performance Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... Hanford Lifecycle Scope, Schedule & Cost Report Quarterly Submitted - A summary quarterly ... employees and nine subcontractor employees were hired to coincide with the new work scope. ...

  7. Monthly Performance Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... ACCOMPLISHMENTS 2016 Hanford Lifecycle Scope, Schedule and Cost Report (Tri-Party ... The full scope audits of the Hanford Site Pension and Savings Plans and the Hanford ...

  8. CAF Bug Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    caf-coarray-fortrancaf-bug-reportsrss There are currently no significant reported user bugs with CAF. http:www.nersc.govuserssoftwarecompilerscaf-coarray-fortran...

  9. PGI Bug Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    June 2015 Internal compiler error for function pointer with identically named arguments June 9, 2015 by Scott French, NERSC USG Status: Bug 21435 reported to PGI...

  10. PGI Bug Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    pgipgi-bug-reportsrss Internal compiler error for function pointer with identically named arguments http:www.nersc.govuserssoftwarecompilerspgipgi-bug-reports...

  11. EMSL 2009 Annual Report

    SciTech Connect

    Showalter, Mary Ann; Kathmann, Loel E.; Manke, Kristin L.; Wiley, Julie G.; Reed, Jennifer R.

    2010-02-26

    The EMSL 2009 Annual Report describes the science conducted at EMSL during 2009 as well as outreach activities and awards and honors received by users and staff.

  12. Progress Report for Workgroup ...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    would need mechanism to ensure regular reporting of savings o Under program evaluation option, what would standards be for determining whether state audits could replace...

  13. Table for Reports - ESG

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Laboratory (PDF) Worker and Environmental Assessment of Potential Unbound Engineered Nanoparticle Releases Phase I Final Report: Data Collection, 2009 (PDF) Phase II Final...

  14. 2007 Annual Report

    SciTech Connect

    2007-01-01

    This annual report includes: a brief overview of Western; FY 2007 highlights; FY 2007 Integrated Resource Planning, or IRP, survey; and financial data.

  15. Final Technical Report

    SciTech Connect

    Herrin, David L

    2011-04-21

    This report summarizes many of the projects, and lists all of the publications and persons trained with support from the grant.

  16. BPA 2002 Annual Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    STATEMENTS 2002 Annual Report of the Bonneville Power Administration Cover photo BPA fish biologist Andy Thoms (upper right) works with students from H.B. Lee Middle School...

  17. Final Technical Report Division

    Office of Scientific and Technical Information (OSTI)

    Technical Report Division of Nuclear Physics in the Department of Energy DOE Award ... Center for Theoretical Studies in Nuclear Physics and Related Areas (ECT*), Trento, ...

  18. Online Abstracts and Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Online Abstracts and Reports - Sandia Energy Energy Search Icon Sandia Home Locations Contact ... Algae Testbed Battery Abuse Testing Laboratory Center for Infrastructure Research ...

  19. ONO Annual Report 2015

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    REPORT TO CONGRESS ■ I OFFICE OF THE NATIONAL OMBUDSMAN 2014 ANNUAL REPORT TO CONGRESS Partnering TO DELIVER solutions AND value TO SMALL BUSINESS I I ■ 2014 ANNUAL REPORT TO CONGRESS " It was more than obvious the Navy called this meeting with the so le purpose to listen... examine all the relevant facts, discuss what they could and could not do and make an acceptable resolution...I'm pleased to report that all three issues were addressed and the outcome very favorable. -TECHNICAL

  20. Sludge adherence summary report

    SciTech Connect

    Bergmann, D.W., Westinghouse Hanford

    1996-07-11

    This report summarizes the results from the first sludge adherence tests performed in the 105-K East Basin on N Reactor fuel.

  1. Requirements Review Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Editors, "High Energy Physics and Nuclear Physics Network Requirements - Final Report", ESnet Network Requirements Workshop, August 2013, LBNL 6642E Download File: HEP-NP-Net-Req...

  2. Monthly Performance Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    MSC Monthly Performance Report OCT 2013 DOERL-2009-113 ... Rev 49 iii CONTENTS EXECUTIVE OVERVIEW 1.0 INTRODUCTION ... 4 3.0 SAFETY PERFORMANCE ...

  3. Intel Bug Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    4 C++11 header files appear missing on Edison December 3, 2014 by Scott French, NERSC USG Status: Reported to Cray (801693), Workaround available

  4. Product Pipeline Reports Tutorial

    Energy Information Administration (EIA) (indexed site)

    Petroleum > Petroleum Survey Forms> Petroleum Survey Forms Tutorial Product Pipeline Reports Tutorial Content on this page requires a newer version of Adobe Flash Player. Get Adobe ...

  5. 2007 Site Environmental Report

    SciTech Connect

    Ratel,K.

    2008-10-01

    Brookhaven National Laboratory (BNL) prepares an annual Site Environmental Report (SER) in accordance with DOE Order 231.1A, Environment, Safety and Health Reporting of the U.S. Department of Energy. The report is written to inform the public, regulators, employees, and other stakeholders of the Laboratory's environmental performance during the calendar year in review. Volume I of the SER summarizes environmental data; environmental management performance; compliance with applicable DOE, federal, state, and local regulations; and performance in restoration and surveillance monitoring programs. BNL has prepared annual SERs since 1971 and has documented nearly all of its environmental history since the Laboratory's inception in 1947. Volume II of the SER, the Groundwater Status Report, also is prepared annually to report on the status of and evaluate the performance of groundwater treatment systems at the Laboratory. Volume II includes detailed technical summaries of groundwater data and its interpretation, and is intended for internal BNL users, regulators, and other technically oriented stakeholders. A brief summary of the information contained in Volume II is included in this volume in Chapter 7, Groundwater Protection. Both reports are available in print and as downloadable files on the BNL web page at http://www.bnl.gov/ewms/ser/. An electronic version on compact disc is distributed with each printed report. In addition, a summary of Volume I is prepared each year to provide a general overview of the report, and is distributed with a compact disc containing the-length report.

  6. DOE Final Report

    SciTech Connect

    Hinzman, Larry D.; Long, James; Newby, Greg B.

    2014-01-08

    This final report contains a summary of work accomplished in the establishment of a Climate Data Center at the International Arctic Research Center, University of Alaska Fairbanks.

  7. Radiation Therapy Oncology Group Translational Research Program Stem Cell Symposium: Incorporating Stem Cell Hypotheses into Clinical Trials

    SciTech Connect

    Woodward, Wendy A. Bristow, Robert G.; Clarke, Michael F.; Coppes, Robert P.; Cristofanilli, Massimo; Duda, Dan G.; Fike, John R.; Hambardzumyan, Dolores; Hill, Richard P.; Jordan, Craig T.; Milas, Luka; Pajonk, Frank; Curran, Walter J.; Dicker, Adam P.; Chen Yuhchyau

    2009-08-01

    At a meeting of the Translation Research Program of the Radiation Therapy Oncology Group held in early 2008, attendees focused on updating the current state of knowledge in cancer stem cell research and discussing ways in which this knowledge can be translated into clinical use across all disease sites. This report summarizes the major topics discussed and the future directions that research should take. Major conclusions of the symposium were that the flow cytometry of multiple markers in fresh tissue would remain the standard technique of evaluating cancer-initiating cells and that surrogates need to be developed for both experimental and clinical use.

  8. Combinational chelation therapy abrogates lead-induced neurodegeneration in rats

    SciTech Connect

    Pachauri, Vidhu; Saxena, Geetu; Mehta, Ashish; Mishra, Deepshikha; Flora, Swaran J.S.

    2009-10-15

    Lead, a ubiquitous and potent neurotoxicant causes oxidative stress which leads to numerous neurobehavioral and physiological alterations. The ability of lead to bind sulfhydryl groups or compete with calcium could be one of the reasons for its debilitating effects. In the present study, we addressed: i) if chelation therapy could circumvent the altered oxidative stress and prevent neuronal apoptosis in chronic lead-intoxicated rats, ii) whether chelation therapy could reverse biochemical and behavioral changes, and iii) if mono or combinational therapy with captopril (an antioxidant) and thiol chelating agents (DMSA/MiADMSA) is more effective than individual thiol chelator in lead-exposed rats. Results indicated that lead caused a significant increase in reactive oxygen species, nitric oxide, and intracellular free calcium levels along with altered behavioral abnormalities in locomotor activity, exploratory behavior, learning, and memory that were supported by changes in neurotransmitter levels. A fall in membrane potential, release of cytochrome c, and DNA damage indicated mitochondrial-dependent apoptosis. Most of these alterations showed significant recovery following combined therapy with captopril with MiADMSA and to a smaller extend with captopril + DMSA over monotherapy with these chelators. It could be concluded from our present results that co-administration of a potent antioxidant (like captopril) might be a better treatment protocol than monotherapy to counter lead-induced oxidative stress. The major highlight of the work is an interesting experimental evidence of the efficacy of combinational therapy using an antioxidant with a thiol chelator in reversing neurological dystrophy caused due to chronic lead exposure in rats.

  9. Predictors of Postoperative Complications After Trimodality Therapy for Esophageal Cancer

    SciTech Connect

    Wang, Jingya [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Wei, Caimiao [Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Tucker, Susan L. [Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Myles, Bevan; Palmer, Matthew [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Hofstetter, Wayne L.; Swisher, Stephen G. [Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Ajani, Jaffer A. [Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Cox, James D.; Komaki, Ritsuko; Liao, Zhongxing [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Lin, Steven H., E-mail: SHLin@mdanderson.org [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2013-08-01

    Purpose: While trimodality therapy for esophageal cancer has improved patient outcomes, surgical complication rates remain high. The goal of this study was to identify modifiable factors associated with postoperative complications after neoadjuvant chemoradiation. Methods and Materials: From 1998 to 2011, 444 patients were treated at our institution with surgical resection after chemoradiation. Postoperative (pulmonary, gastrointestinal [GI], cardiac, wound healing) complications were recorded up to 30 days postoperatively. Kruskal-Wallis tests and ?{sup 2} or Fisher exact tests were used to assess associations between continuous and categorical variables. Multivariate logistic regression tested the association between perioperative complications and patient or treatment factors that were significant on univariate analysis. Results: The most frequent postoperative complications after trimodality therapy were pulmonary (25%) and GI (23%). Lung capacity and the type of radiation modality used were independent predictors of pulmonary and GI complications. After adjusting for confounding factors, pulmonary and GI complications were increased in patients treated with 3-dimensional conformal radiation therapy (3D-CRT) versus intensity modulated radiation therapy (IMRT; odds ratio [OR], 2.018; 95% confidence interval [CI], 1.104-3.688; OR, 1.704; 95% CI, 1.03-2.82, respectively) and for patients treated with 3D-CRT versus proton beam therapy (PBT; OR, 3.154; 95% CI, 1.365-7.289; OR, 1.55; 95% CI, 0.78-3.08, respectively). Mean lung radiation dose (MLD) was strongly associated with pulmonary complications, and the differences in toxicities seen for the radiation modalities could be fully accounted for by the MLD delivered by each of the modalities. Conclusions: The radiation modality used can be a strong mitigating factor of postoperative complications after neoadjuvant chemoradiation.

  10. Environmental Report 2008

    SciTech Connect

    Gallegos, G; Bertoldo, N A; Campbell, C G; Cerruti, S; Dibley, V; Doman, J L; Grayson, A R; Jones, H E; Kumamoto, G; MacQueen, D H; Nelson, J C; Paterson, L; Revelli, M A; Wegrecki, A M; Wilson, K; Woollett, J

    2009-09-16

    The purposes of the Lawrence Livermore National Laboratory Environmental Report 2008 are to record Lawrence Livermore National Laboratory's (LLNL's) compliance with environmental standards and requirements, describe LLNL's environmental protection and remediation programs, and present the results of environmental monitoring at the two LLNL sites - the Livermore site and Site 300. The report is prepared for the U.S. Department of Energy (DOE) by LLNL's Environmental Protection Department. Submittal of the report satisfies requirements under DOE Order 231.1A, Environmental Safety and Health Reporting, and DOE Order 5400.5, Radiation Protection of the Public and Environment. The report is distributed electronically and is available at https://saer.lln.gov/, the website for the LLNL annual environmental report. Previous LLNL annual environmental reports beginning in 1994 are also on the website. Some references in the electronic report text are underlined, which indicates that they are clickable links. Clicking on one of these links will open the related document, data workbook, or website that it refers to. The report begins with an executive summary, which provides the purpose of the report and an overview of LLNL's compliance and monitoring results. The first three chapters provide background information: Chapter 1 is an overview of the location, meteorology, and hydrogeology of the two LLNL sites; Chapter 2 is a summary of LLNL's compliance with environmental regulations; and Chapter 3 is a description of LLNL's environmental programs with an emphasis on the Environmental Management System including pollution prevention. The majority of the report covers LLNL's environmental monitoring programs and monitoring data for 2008: effluent and ambient air (Chapter 4); waters, including wastewater, storm water runoff, surface water, rain, and groundwater (Chapter 5); and terrestrial, including soil, sediment, vegetation, foodstuff, ambient radiation, and special status

  11. ARM - Program Documents & Technical Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    govPublicationsProgram Documents & Technical Reports Additional Sorting By Report Type ... Publications Journal Articles Conference Documents Program Documents & Technical Reports ...

  12. 2015 Uranium Marketing Annual Report

    Gasoline and Diesel Fuel Update

    Uranium Marketing Annual Report 2015 Uranium Marketing Annual Report Release Date: May 24, 2016 Next Release Date: May 2017 Number of purchasers Quantity with reported price ...

  13. Definitive Chemoradiation Therapy Following Surgical Resection or Radiosurgery Plus Whole-Brain Radiation Therapy in Non-Small Cell Lung Cancer Patients With Synchronous Solitary Brain Metastasis: A Curative Approach

    SciTech Connect

    Parlak, Cem; Mertsoylu, Hüseyin; Güler, Ozan Cem; Onal, Cem; Topkan, Erkan

    2014-03-15

    Purpose/Objectives: The aim of this study was to evaluate the impact of definitive thoracic chemoradiation therapy following surgery or stereotactic radiosurgery (SRS) and whole-brain radiation therapy (WBRT) on the outcomes of patients with non-small cell lung cancer (NSCLC) with synchronous solitary brain metastasis (SSBM). Methods and Materials: A total of 63 NSCLC patients with SSBM were retrospectively evaluated. Patients were staged using positron emission tomography-computed tomography in addition to conventional staging tools. Thoracic radiation therapy (TRT) with a total dose of 66 Gy in 2 Gy fractions was delivered along with 2 cycles of cisplatin-based chemotherapy following either surgery plus 30 Gy of WBRT (n=33) or SRS plus 30 Gy of WBRT (n=30) for BM. Results: Overall, the treatment was well tolerated. All patients received planned TRT, and 57 patients (90.5%) were also able to receive 2 cycles of chemotherapy. At a median follow-up of 25.3 months (7.1-52.1 months), the median months of overall, locoregional progression-free, neurological progression-free, and progression-free survival were 28.6, 17.7, 26.4, and 14.6, respectively. Both univariate and multivariate analyses revealed that patients with a T1-T2 thoracic disease burden (P=.001), a nodal stage of N0-N1 (P=.003), and no weight loss (P=.008) exhibited superior survival. Conclusions: In the present series, surgical and radiosurgical treatments directed toward SSBM in NSCLC patients were equally effective. The similarities between the present survival outcomes and those reported in other studies for locally advanced NSCLC patients indicate the potentially curative role of definitive chemoradiation therapy for highly selected patients with SSBM.

  14. Microhole Tubing Bending Report

    DOE Data Explorer

    Oglesby, Ken

    A downhole tubing bending study was made and is reported herein. IT contains a report and 2 excel spreadsheets to calculate tubing bending and to estimate contact points of the tubing to the drilled hole wall (creating a new support point).

  15. Inert Anode Report

    SciTech Connect

    none,

    1999-07-01

    This ASME report provides a broad assessment of open literature and patents that exist in the area of inert anodes and their related cathode systems and cell designs, technologies that are relevant for the advanced smelting of aluminum. The report also discusses the opportunities, barriers, and issues associated with these technologies from a technical, environmental, and economic viewpoint.

  16. Microhole Tubing Bending Report

    DOE Data Explorer

    Oglesby, Ken

    2012-01-01

    A downhole tubing bending study was made and is reported herein. IT contains a report and 2 excel spreadsheets to calculate tubing bending and to estimate contact points of the tubing to the drilled hole wall (creating a new support point).

  17. GCFR development status report

    SciTech Connect

    Not Available

    1980-05-01

    This report describes the major design features of the gas-cooled fast breeder reactor being developed in the United States principally at General Atomic Company. The report gives the general design strategy and highlights the design features of the reactor core and the nuclear steam supply components. It describes the design results on plant safety and licensing.

  18. Sandia National Laboratories: News: Publications: HPC Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    HPC Annual Reports Annual Report Environmental Reports Fact Sheets Labs Accomplishments Lab News Partnerships Annual Report Research Magazine HPC Annual Reports Search Sandia Publications Strategic Plan News HPC Annual Reports 2016 Report HPC Annual Report 2016 HPC Annual Report (PDF, 4 MB) 2015 Report HPC Annual Report 2015 HPC Annual Report (PDF, 9 MB) 2014 Report Environmental Report cover 2014 HPC Annual Report (PDF, 10 MB) 2013 Report HPC Annual Report cover 2013 HPC Annual Report (PDF,

  19. Boron containing compounds and their preparation and use in neutron capture therapy

    DOEpatents

    Gabel, D.

    1992-09-01

    The present invention pertains to boron containing thiouracil derivatives, their method of preparations, and their use in the therapy of malignant melanoma using boron neutron capture therapy. No Drawings

  20. Thiourea derivatives, methods of their preparation and their use in neutron capture therapy of malignant melanoma

    DOEpatents

    Gabel, D.

    1991-06-04

    The present invention pertains to boron containing thiouracil derivatives, their method of preparations, and their use in the therapy of malignant melanoma using boron neutron capture therapy. No Drawings

  1. Environmental Report 2007

    SciTech Connect

    Mathews, S; Gallegos, G; Berg, L L; Bertoldo, N A; Campbell, C G; Cerruti, S; Doman, J L; Ferry, L S; Grayson, A R; Jones, H E; Kumamoto, G; Larson, J; MacQueen, D H; Paterson, L; Revelli, M A; Ridley, M; Rueppel, D; Wegrecki, A M; Wilson, K; Woollett, J

    2008-09-24

    The purposes of the 'Lawrence Livermore National Laboratory Environmental Report 2007' are to record Lawrence Livermore National Laboratory's (LLNL's) compliance with environmental standards and requirements, describe LLNL's environmental protection and remediation programs, and present the results of environmental monitoring at the two LLNL sites--the Livermore site and Site 300. The report is prepared for the U.S. Department of Energy (DOE) by LLNL's Environmental Protection Department. Submittal of the report satisfies requirements under DOE Order 231.1A, Environmental Safety and Health Reporting, and DOE Order 5400.5, Radiation Protection of the Public and Environment. The report is distributed electronically and is available at https://saer.lln.gov/, the website for the LLNL annual environmental report. Previous LLNL annual environmental reports beginning in 1994 are also on the website. Some references in the electronic report text are underlined, which indicates that they are clickable links. Clicking on one of these links will open the related document, data workbook, or website that it refers to. The report begins with an executive summary, which provides the purpose of the report and an overview of LLNL's compliance and monitoring results. The first three chapters provide background information: Chapter 1 is an overview of the location, meteorology, and hydrogeology of the two LLNL sites; Chapter 2 is a summary of LLNL's compliance with environmental regulations; and Chapter 3 is a description of LLNL's environmental programs with an emphasis on the Environmental Management System including pollution prevention. The majority of the report covers LLNL's environmental monitoring programs and monitoring data for 2007: effluent and ambient air (Chapter 4); waters, including wastewater, storm water runoff, surface water, rain, and groundwater (Chapter 5); and terrestrial, including soil, sediment, vegetation, foodstuff, ambient radiation, and special status

  2. Annual Reports | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Note: Some of the following documents are in PDF and will require Adobe Reader for ... Report for 2009 Annual Report for 2008 (pdf) Annual Report for 2007 (pdf) Annual Report ...

  3. ARM - ARM Operations Quarterly Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Operations Quarterly Reports Publications Journal Articles Conference Documents Program Documents Technical Reports Publications Database Public Information Materials Image Library...

  4. Intel Bug Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Intel » Intel Bug Reports Intel Bug Reports Intel C++ compiler error: stl_iterator_base_types.h December 7, 2015 by Scott French Because the system-supplied version of GCC is relatively old (4.3.4) it is common practice to load the gcc module on our Cray systems when C++11 support is required under the Intel C++ compilers. Read the full post C++11 header files appear missing on Edison December 3, 2014 by Scott French, NERSC USG Status: Reported to Cray (801693), Workaround available Read the

  5. Weekly Petroleum Status Report

    Energy Information Administration (EIA) (indexed site)

    208(2016-46) Distribution Category UC-98 Data for Week Ended: November 11, 2016 Weekly Petroleum Status Report Weekly Petroleum Status Report/Energy Information Administration ii EIA DATA ARE AVAILABLE IN ELECTRONIC FORM The tables in the Weekly Petroleum Status Report (WPSR) are posted to the web site after 10:30 a.m. Eastern Standard Time (EST) on Wednesdays in CSV and XLS formats. PDF fles are posted to the web site after 1:00 p.m. on Wednesdays. For some weeks that include holidays, posting

  6. International petroleum statistics report

    SciTech Connect

    1995-10-01

    The International Petroleum Statistics Report is a monthly publication that provides current international oil data. This report presents data on international oil production, demand, imports, exports and stocks. The report has four sections. Section 1 contains time series data on world oil production, and on oil demand and stocks in the Organization for Economic Cooperation and Development (OECD). Section 2 presents an oil supply/demand balance for the world, in quarterly intervals for the most recent two years. Section 3 presents data on oil imports by OECD countries. Section 4 presents annual time series data on world oil production and oil stocks, demand, and trade in OECD countries.

  7. Report Wildlife Encounters

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Wildlife Encounters Report Wildlife Encounters Report any encounters with wildlife in the Los Alamos area. April 12, 2012 A mama black bear and her cub A mama black bear and her cub in Los Alamos. Contact Environmental Communication & Public Involvement P.O. Box 1663 MS M996 Los Alamos, NM 87545 (505) 667-0216 Email If you find an injured bird, contact the Santa Fe Raptor Center. Have a close encounter? Report the following Any wildlife incidents or encounters Migratory bird injury or

  8. Weekly Petroleum Status Report

    Energy Information Administration (EIA) (indexed site)

    ‹ See All Petrolem Reports Weekly Petroleum Status Report Data for week ending Nov. 11, 2016 | Release Date: Nov. 16, 2016 | Next Release Date: Nov. 23, 2016 | full report Previous Issues Week: November 16, 2016 November 9, 2016 November 2, 2016 October 26, 2016 October 19, 2016 October 13, 2016 October 5, 2016 September 28, 2016 September 21, 2016 September 14, 2016 September 8, 2016 August 31, 2016 August 24, 2016 August 17, 2016 August 10, 2016 August 3, 2016 prior issues Go The petroleum

  9. Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

    DOEpatents

    Miura, M.; Slatkin, D.N.

    1995-10-03

    A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na{sub 4}B{sub 12}I{sub 11}SSB{sub 12}I{sub 11}, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy. 1 fig.

  10. Nanoscience and Nanotechnology: From Energy Applications to Advanced Medical Therapies

    ScienceCinema

    Tijana Rajh

    2016-07-12

    Dr. Rajh will present a general talk on nanotechnology – an overview of why nanotechnology is important and how it is useful in various fields. The specific focus will be on Solar energy conversion, environmental applications and advanced medical therapies. She has broad expertise in synthesis and characterization of nanomaterials that are used in nanotechnology including novel hybrid systems connecting semiconductors to biological molecules like DNA and antibodies. This technology could lead to new gene therapy procedures, cancer treatments and other medical applications. She will also discuss technologies made possible by organizing small semiconductor particles called quantum dots, materials that exhibit a rich variety of phenomena that are size and shape dependent. Development of these new materials that harnesses the unique properties of materials at the 1-100 nanometer scale resulted in the new field of nanotechnology that currently affects many applications in technological and medical fields.

  11. Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

    DOEpatents

    Miura, M.; Slatkin, D.N.

    1997-03-18

    A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na{sub 4}B{sub 12}I{sub 11}SSB{sub 12}I{sub 11}, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy. 1 fig.

  12. Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

    DOEpatents

    Miura, M.; Slatkin, D.N.

    1997-08-05

    A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na{sub 4}B{sub 12}I{sub 11}SSB{sub 12}I{sub 11}, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy. 1 fig.

  13. Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

    DOEpatents

    Miura, Michiko; Slatkin, Daniel N.

    1997-08-05

    A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized. by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na.sub.4 B.sub.12 I.sub.11 SSB.sub.12 I.sub.11, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy.

  14. Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

    DOEpatents

    Miura, Michiko; Slatkin, Daniel N.

    1997-03-18

    A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na.sub.4 B.sub.12 I.sub.11 SSB.sub.12 I.sub.11, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy.

  15. Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

    DOEpatents

    Miura, Michiko; Slatkin, Daniel N.

    1995-10-03

    A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na.sub.4 B.sub.12 I.sub.11 SSB.sub.12 I.sub.11, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy.

  16. Aurora final report

    SciTech Connect

    Robert, Dross; Amedeo, Conti

    2013-12-06

    Final Technical report detailing the work done by Nuvera and its partners to fulfill the goals of the program "Transport Studies Enabling Efficiency Optimization of Cost-Competitive Fuel Cell Stacks" (a.k.a. AURORA)

  17. 2002 SITE ENVIRONMENTAL REPORT.

    SciTech Connect

    BROOKHAVEN NATIONAL LABORATORY

    2003-10-01

    The 2002 Site Environmental Report (SER) is prepared in accordance with DOE Order 231.1, ''Environment, Safety and Health Reporting'', and summarizes the status of Brookhaven National Laboratory's (BNL) environmental programs and performance and restoration efforts, as well as any impacts, both past and present, that Laboratory operations have had on the environment. The document is intended to be technical in nature. A summary of the report is also prepared as a separate document to provide a general overview and includes a CD version of the full report. Operated by Brookhaven Science Associates (BSA) for the Department of Energy (DOE), BNL manages its world-class scientific research with particular sensitivity to environmental and community issues. BNL's motto, ''Exploring Life's Mysteries...Protecting its Future'', reflects BNL's management philosophy to fully integrate environmental stewardship into all facets of its missions, with a health balance between science and the environment.

  18. Drilling Productivity Report

    Gasoline and Diesel Fuel Update

    By law, EIA's data, analyses, and forecasts are independent of approval by any other officer or employee of the United States Government. The views in this report therefore should ...

  19. Capital Reporting Company Quadrennial ...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ... The war on poverty, which was 20 initiated with very dramatics walks from 21 Appalachia ... 07-21-2014 (866) 448 - DEPO www.CapitalReportingCompany.com 2014 44 1 poverty there. ...

  20. ARM - Annual Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    For proper viewing, the ARM annual reports should be viewed with Adobe Acrobat Reader. Download the latest version from the Adobe Reader website. FY 2015 | PDF, 8.9MB FY 2014 | ...

  1. Market Effects Evaluation Report

    Energy.gov [DOE]

    A report evaluating the U.S. Department of Energy Solid State Lighting Program for FY 2006 – FY 2012 to determine its effectiveness and progress toward achieving program objectives and to assess...

  2. JPRS report, nuclear developments

    SciTech Connect

    1991-03-28

    This report contains articles concerning the nuclear developments of the following countries: (1) China; (2) Japan, North Korea, South Korea; (3) Bulgaria; (4) Argentina, Brazil, Honduras; (5) India, Iran, Pakistan, Syria; (6) Soviet Union; and (7) France, Germany, Turkey.

  3. Capital Reporting Company Quadrennial ...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ...CapitalReportingCompany.com 2014 120 1 how to adapt to the new oil which is, in New 2 Mexico, a sweet API 40, essentially similar to the 3 North Dakota oil. We have a sweet oil. ...

  4. RPSEA REPORT PROCEDURES

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    RPSEA Final Technical Report 08121.2201.02.FINAL Heavy Viscous Oil Pressure, Volume, and ... the physical properties of heavy viscous oil systems is a k ey aspect of a successful ...

  5. Full Final Report

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    REPOR FULL FINAL REPOR T T SECTION III SECTION III FULL FINAL REPORT SECTION III Individual Project Summaries Table of Contents Algal Biology ..................................................................................................3 Cultivation ...................................................................................................41 Harvesting and Extraction .............................................................................65 Fuel Conversion

  6. Transportation Baseline Report

    SciTech Connect

    Fawcett, Ricky Lee; Kramer, George Leroy Jr.

    1999-12-01

    The National Transportation Program 1999 Transportation Baseline Report presents data that form a baseline to enable analysis and planning for future Department of Energy (DOE) Environmental Management (EM) waste and materials transportation. In addition, this Report provides a summary overview of DOEs projected quantities of waste and materials for transportation. Data presented in this report were gathered as a part of the IPABS Spring 1999 update of the EM Corporate Database and are current as of July 30, 1999. These data were input and compiled using the Analysis and Visualization System (AVS) which is used to update all stream-level components of the EM Corporate Database, as well as TSD System and programmatic risk (disposition barrier) information. Project (PBS) and site-level IPABS data are being collected through the Interim Data Management System (IDMS). The data are presented in appendices to this report.

  7. Final Technical Report

    SciTech Connect

    Ritchie, Jack L

    2012-07-26

    The activity reported includes work on several experiments (BNL E871 at Brookhaven National Lab, HERA-B at DESY, MINOS at Fermilab, BABAR at SLAC, and Minerva at Fermilab) and theory.

  8. International petroleum statistics report

    SciTech Connect

    1996-03-01

    This report presents data on international oil production, demand, imports, exports, and stocks. World oil production and OECD demand data are for the years 1970 through 1994; OECD stocks from 1973 through 1994; and OECD trade from 1984 through 1994.

  9. GNU Bug Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    no significant reported user bugs with the GNU compilers. November 18, 2013 by Mike Stewart, NERSC USG. Status: No current NERSC user bugs. Read the full post Subscribe via RSS...

  10. 2010 Annual Report

    SciTech Connect

    2010-01-01

    This annual report includes: an overview of Western; approaches for future hydropower and transmission service; major achievements in FY 2010; FY 2010 customer Integrated Resource Planning, or IRP, survey; and financial data.

  11. CX-100 Final Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    SAND2008-4648 Unlimited Release Printed July 2008 Blade System Design Studies Phase II: Final Project Report Derek S. Berry TPI Composites, Inc. 373 Market Street Warren, RI 02885...

  12. Monthly Performance Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... 1.1 KEY ACCOMPLISHMENTS Hanford Lifecycle Scope, Schedule and Cost Report (Tri-Party ... Hanford contractor's ARRA work scope under Site Basic Services and Usage-Based Services. ...

  13. 2009 Annual Report

    SciTech Connect

    2009-01-01

    This annual report includes: a brief overview of Western; some of our major achievements in FY 2009; FY 2009 customer Integrated Resource Planning, or IRP, survey; and financial data.

  14. ARM - Technical Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... Report (PDF, 1.4MB) ProSensing Inc. 2010 Whole Sky Imager Retrieval Guide (PDF, 2.0MB) ... Shaw, RA, M Beals, JP Fugal, SM Spuler, N Black, and J Lu 2012 ARM Standards Policy ...

  15. NETL Report format template

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... research and use of varied techniques to evaluate the risk of hydrocarbon extraction. ... K. M. Atlas of Gulf of Mexico Gas and Oil Sands as of January 1, 1999; OCS Report; U.S. ...

  16. Report from the Street

    Energy Saver

    SHERMAN STREET, CAMBRIDGE, MA 02140 617.354.4502 LAMPARTNERS.COM BLOG.LAMPARTNERS.COM Report from the Street Glenn Heinmiller, FIALD, LC, LEED AP Principal, Lam Partners Chair,...

  17. Quarterly Progress Report

    Office of Scientific and Technical Information (OSTI)

    Covering Period: June 1, 2008 to December 31, 2009 Date of Report: May 4, 2010 Recipient: The Solar Energy Consortium Award Number: DE-FG36-08GO88011 Working Partners: Prism Solar ...

  18. SWERA_Final_Report

    OpenEI (Open Energy Information) [EERE & EIA]

    throughout the day such as trough collectors or dishes. The estimation for radiation on 3 Solar Energy Resources, Technical Report 3, CESEN 1986 2-2 tilted surface analysis used...

  19. Complex Flow Workshop Report

    SciTech Connect

    none,

    2012-05-01

    This report documents findings from a workshop on the impacts of complex wind flows in and out of wind turbine environments, the research needs, and the challenges of meteorological and engineering modeling at regional, wind plant, and wind turbine scales.

  20. International petroleum statistics report

    SciTech Connect

    1996-12-01

    This report presents data on international oil production, demand, imports, and stocks. World oil production and OECD demand data are for the years 1970 through 1995; stocks from 1973 through 1995, and trade from 1985 through 1995.

  1. Microsoft Word - Final Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    J. Michael Doster NCSU September 30, 2013 CASL-8-2013-0201-000 Final Report L3.THM.CFD.P7.07 Dr. J. Michael Doster Nuclear Engineering Department North Carolina State University ...

  2. Annual Report 2008.doc

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... the ACHP regulations and Executive Order 13287: "Preserve ... War FY08 Annual Summary Report Page 4 of 14 Register of ... Table 6 Theme FY 2008 Accomplishments Overall Status as of ...

  3. ARM - Reporting Requirements

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    required to report to the DOE ARM Program Director, to the DOE's Office of Biological and Environmental Research, and to the White House Office of Management and Budget. A primary...

  4. Monthly Reports 2014

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Waste Isolation Pilot Plant Hazardous Waste Facility Permit Number: NM4890139088-TSDF Jose R. FrancoCBFO and Robert L. McQuinnNWP dated December 29, 2014 Monthly Report for the...

  5. Weekly Reports 2014

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Waste Isolation Pilot Plant Hazardous Waste Facility Permit Number: NM4890139088-TSDF Jose R. FrancoCBFO and Robert L. McQuinnNWP dated May 27, 2014 Weekly Report as Requested...

  6. Intel Bug Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    November 2013 Compiling with -ipo produces "unresolved" warning messages at link time on Cray systems November 18, 2013 by Mike Stewart, NERSC USG Status: Reported to the darshan developers

  7. Report2003.doc

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    III. Definitions of Terms and Acronyms Used in the Report. ... current fiscal year 1013 (Enter this number also in Line ... (some records involved search adequacy) 5: Remand: 9 7 ...

  8. ALS Activity Report 2004

    SciTech Connect

    Tamura , Lori S.

    2005-07-11

    This annual report of the Advanced Light Source details science highlights and facility developments during the year. It also offers information on events sponsored by the facility, technical specifications, and staff and publication information.

  9. HEP Final Project Report

    SciTech Connect

    Chen, Chunhui

    2013-05-21

    In this report, we summarize the research activity funded by the DOE award DE-FG02-12ER41827 (DE-SC0007892) during the funding period (May 1, 2012- March 31, 2013).

  10. Report Wildlife Encounters

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Encounters Report any encounters with wildlife in the Los Alamos area. April 12, 2012 A mama black bear and her cub A mama black bear and her cub in Los Alamos. Contact...

  11. HPC Workshop Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    HPC Workshop Reports HPC Workshop Reports Sort by: Default | Name | Date (low-high) | Date (high-low) | Source | Category Petascale Systems Integration into Large Scale Facilities Workshop August 31, 2007 | URL: https://outreach.scidac.gov/pibp/ Download File: PetascaleFinalDraft.doc | doc | 216 KB This workshop was the first given in the HPC Best Practices Workshop Series. Held in San Francisco, May 15-16 2007, the workshop looked at the challenges and opportunities that come with Petascale

  12. Blackout Final Implementation Report

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Final Report on the Implementation of the Task Force Recommendations U.S.-Canada Power System Outage Task Force Natural Resources Canada U.S. Department of Energy September 2006 Final Report on the Implementation of the Task Force Recommendations U.S.-Canada Power System Outage Task Force September 2006 Natural Resources Canada U.S. Department of Energy Acknowledgments This document was prepared by staff of Natural Resources Canada and the U.S. Department of Energy. The principal contributors

  13. Building America Report Template

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Challenge Home Production Builder Roundtable Report May 2014 NOTICE This report was prepared as an account of work sponsored by an agency of the United States government. Neither the United States government nor any agency thereof, nor any of their employees, subcontractors, or affiliated partners, make any warranty, express or implied, or assume any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or

  14. Weekly Petroleum Status Report

    Energy Information Administration (EIA) (indexed site)

    6 Appendix C Northeast Reserves Reserves inventories are not considered to be in the commercial sector and are excluded from EIA's commercial motor gasoline and distillate fuel oil supply and disposition statistics, such as those reported in the Weekly Petroleum Status Report, Petroleum Supply Monthly, and This Week In Petroleum. Northeast Home Heating Oil Reserve classifed as ultra-low sulfur distillate (15 parts per million) Terminal Operator Location Thousand Barrels Buckeye Partners LP Port

  15. 2011 Peer Review Report

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Cover photo: Geysers Geothermal Power Plant, Calpine Geothermal Technologies Program 2011 Peer Review Report June 2011 U.S. Department of Energy Office of Energy Efficiency and Renewable Energy Geothermal Technologies Program 2011 Peer Review Report June 2011 Allan Jelacic Chair 2011 Geothermal Technologies Peer Review Panel Douglas Hollett Program Manager U.S. DOE Geothermal Technologies Program Greg Stillman Peer Review Lead U.S. DOE Geothermal Technologies Program Table of Contents Executive

  16. Environmental Groundwater Monitoring Report

    Office of Legacy Management (LM)

    -460 Environmental Groundwater Monitoring Report Third Quarter, 1997 October 1997 Approved for public release; further dissemination unlimited. Environmental Restoration U.S. Department of Energy Nevada Operations Office This report has been reproduced directly from the best available copy. 1 - I : ~vailablk to DOE and DOE contractors from the. Office of Scientific - and Technical .Information, P.O. Box 62, Oak Ridge, TN 3783 1 ; prices available from (423) 576-840 1. Available to the public

  17. RPSEA FINAL TECHNICAL REPORT

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    RPSEA FINAL TECHNICAL REPORT 12122.52.FINAL Hugh Daigle, Nicholas W. Hayman, Kyle Spikes, Julia Gale, Peter Eichhubl, Kitty L. Milliken University of Texas at Austin Connectivity between Fractures and Pores in Hydrocarbon-Rich Mudrocks Contract Number 12122-52 June 24, 2016 Principal Investigator: Hugh Daigle Assistant Professor Department of Petroleum and Geosystems Engineering University of Texas at Austin 200 E Dean Keeton St., Stop C0300, Austin, TX 78712-1585 2 LEGAL NOTICE This report was

  18. Special Report: IG-0748

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Management Challenges at the Department of Energy DOE/IG-0748 December 2006 Department of Energy Washington, DC 20585 December 13, 2006 MEMORANLIUM FOR FROM: Inspector General SUBJECT: INFORMATION: Special Report on "Management Challenges at the Department of Energy'' BACKGROUND On an annual basis, the Office of Inspector General identifies what it considers to be the no st signilicant management challenges Facing the Departllleiit of Energy. Now required as part of the Reports

  19. Monthly Report 2015

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    6 Monthly Report for the Reporting Period ending December 31, 2015 as required by NMED Administrative Orders dated February 27, 2014 and May 12, 2014, as Amended by NMED Directives dated August 29, 2014, December 9, 2014, and July 15, 2015 Waste Isolation Pilot Plant Hazardous Waste Facility Permit Number: NM4890139088-TSDF Todd Shrader/CBFO and Philip J. Breidenbach/NWP dated January 29, 2016

  20. Inspection Report: IG-0746

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    l nspector General Office of Inspections and Special Inquiries Inspection Report Work Packages for Site Support Service; at Los Alamos National Laboratory Department of Energy Washington, DC 20585 November 29, 2006 MEMORANDUM FOR TI38 S E C m U R Y FROM: h p Gregor - . riedman Inspector General SUBJECT: INFORMATION: Inspection Report on "Work Packages for Site Support Services at Los Alalnos National Laboratory" The Department of Energy's Los Alarnos National Laboratory (LANL) enhances

  1. Inspection Report: IG-0821

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Inspection Report Fire Suppression and Related Services at Los Alamos National Laboratory DOE/IG-0821 September 2009 U.S. Department of Energy Office of Inspector General Office of Inspections Department of Energy Washington, DC 20585 September 11, 2009 MEMORANDUM FOR THE SECRETARY FROM: Gregory H. Friedman Inspector General SUBJECT: INFORMATION: Inspection Report on "Fire Suppression and Related Services at Los Alamos National Laboratory" BACKGROUND The Department of Energy's (DOE's)

  2. Annual Site Environmental Report

    SciTech Connect

    Finley, Virginia

    2014-10-02

    This report provides the U.S. Department of Energy (DOE) and the public with information on the level of radioactive and non-radioactive pollutants (if any) that are added to the environment as a result of Princeton Plasma Physics Laboratory’s (PPPL) operations. The results of the 2013 environmental surveillance and monitoring program for PPPL’s are presented and discussed. The report also summarizes environmental initiatives, assessments, and community involvement programs that were undertaken in 2013.

  3. Audit Report: IG-0771

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    U.S. Department of Energy Office of Inspector General Office of Audit Services Security Over Personally Identifiable Information DOE/IG-0771 July 2007 Department of Energy 'Sv'ashinyton, DC 20585 J u l y 30, 2007 MEMORAhTDUM FOR FROM: inspector General SUBJECT: INFORMATION: Audit Report on "Security over Personally Identifiable Information" Industry experts have reported that more than 100 million personal privacy records have been lost or stolen over the past two years, including

  4. Audit Report: IG-0781

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    U.S. Department of Energy Office of Inspector General Office of Audit Services Audit Report Continuity of Operations at Bonneville Power Administration DOE/IG-0781 November 2007 Department of Energy Washington, DC 20585 November 6 , 2007 MEMORANDUM FOR THE ADMINISTRATOR, BONNEVILLE POWER ADMNISTRATION - 2 L ~ ; ; K L & L ~ , ; / FROM: Grego d H. Friedman Inspector General SUBJECT: INFORMATION: Audit Report on "Continuity of Operations at Bonneville Power Administration" BACKGROUND

  5. BRCA1 Mutation: A Predictive Marker for Radiation Therapy?

    SciTech Connect

    Kan, Charlene; Zhang, Junran

    2015-10-01

    DNA repair, in particular, DNA double-strand break (DSB) repair, is essential for the survival of both normal and cancer cells. An elaborate repair mechanism has been developed in cells to efficiently repair the damaged DNA. The pathways predominately involved in DSB repair are homologous recombination and classic nonhomologous end-joining, although the alternative NHEJ pathway, a third DSB repair pathway, could also be important in certain contexts. The protein of BRCA1 encoded by the tumor suppressor gene BRCA1 regulates all DSB repair pathways. Given that DSBs represent the most biologically significant lesions induced by ionizing radiation and that impaired DSB repair leads to radiation sensitivity, it has been expected that cancer patients with BRCA1 mutations should benefit from radiation therapy. However, the clinical data have been conflicting and inconclusive. We provide an overview about the current status of the data regarding BRCA1 deficiency and radiation therapy sensitivity in both experimental models and clinical investigations. In addition, we discuss a strategy to potentiate the effects of radiation therapy by poly(ADP-ribose) polymerase inhibitors, the pharmacologic drugs being investigated as monotherapy for the treatment of patients with BRCA1/2 mutations.

  6. Panel summary report

    SciTech Connect

    Gutjahr, A.L.; Kincaid, C.T.; Mercer, J.W.; Murarka, I.P.; Siegel, M.D.; Wierenga, P.J.

    1987-04-01

    The objective of this report is to summarize the various modeling approaches that were used to simulate solute transport in a variably saturated emission. In particular, the technical strengths and weaknesses of each approach are discussed, and conclusions and recommendations for future studies are made. Five models are considered: (1) one-dimensional analytical and semianalytical solutions of the classical deterministic convection-dispersion equation (van Genuchten, Parker, and Kool, this report ); (2) one-dimensional simulation using a continuous-time Markov process (Knighton and Wagenet, this report); (3) one-dimensional simulation using the time domain method and the frequency domain method (Duffy and Al-Hassan, this report); (4) one-dimensional numerical approach that combines a solution of the classical deterministic convection-dispersion equation with a chemical equilibrium speciation model (Cederberg, this report); and (5) three-dimensional numerical solution of the classical deterministic convection-dispersion equation (Huyakorn, Jones, Parker, Wadsworth, and White, this report). As part of the discussion, the input data and modeling results are summarized. The models were used in a data analysis mode, as opposed to a predictive mode. Thus, the following discussion will concentrate on the data analysis aspects of model use. Also, all the approaches were similar in that they were based on a convection-dispersion model of solute transport. Each discussion addresses the modeling approaches in the order listed above.

  7. Urethral Pain Among Prostate Cancer Survivors 1 to 14 Years After Radiation Therapy

    SciTech Connect

    Pettersson, Niclas; Olsson, Caroline; Tucker, Susan L.; Alsadius, David; Wilderaeng, Ulrica; Johansson, Karl-Axel; Steineck, Gunnar

    2013-01-01

    Purpose: To investigate how treatment-related and non-treatment-related factors impact urethral pain among long-term prostate cancer survivors. Methods and Materials: Men treated for prostate cancer with radiation therapy at the Sahlgrenska University Hospital in Goeteborg, Sweden from 1993 to 2006 were approached with a study-specific postal questionnaire addressing symptoms after treatment, including urethral burning pain during urination (n=985). The men had received primary or salvage external-beam radiation therapy (EBRT) or EBRT in combination with brachytherapy (BT). Prescribed doses were commonly 70 Gy in 2.0-Gy fractions for primary and salvage EBRT and 50 Gy plus 2 Multiplication-Sign 10.0 Gy for EBRT + BT. Prostatic urethral doses were assessed from treatment records. We also recruited 350 non-pelvic-irradiated, population-based controls matched for age and residency to provide symptom background rates. Results: Of the treated men, 16% (137 of 863) reported urethral pain, compared with 11% (27 of 242) of the controls. The median time to follow-up was 5.2 years (range, 1.1-14.3 years). Prostatic urethral doses were similar to prescription doses for EBRT and 100% to 115% for BT. Fractionation-corrected dose and time to follow-up affected the occurrence of the symptom. For a follow-up {>=}3 years, 19% of men (52 of 268) within the 70-Gy EBRT + BT group reported pain, compared with 10% of men (23 of 222) treated with 70 Gy primary EBRT (prevalence ratio 1.9; 95% confidence interval 1.2-3.0). Of the men treated with salvage EBRT, 10% (20 of 197) reported urethral pain. Conclusions: Survivors treated with EBRT + BT had a higher risk for urethral pain compared with those treated with EBRT. The symptom prevalence decreased with longer time to follow-up. We found a relationship between fractionation-corrected urethral dose and pain. Among long-term prostate cancer survivors, the occurrence of pain was not increased above the background rate for prostatic urethral

  8. INEEL Advanced Radiotherapy Research Program Annual Report 2001

    SciTech Connect

    Venhuizen, James Robert

    2002-04-01

    This report summarizes the major activities and accomplishments of the Idaho National Engineering and Environmental Laboratory (INEEL) Advanced Radiotherapy Research Program for calendar year 2001. Applications of supportive research and development, as well as technology deployment in the fields of chemistry, radiation physics and dosimetry, and neutron source design and demonstration are described. Contributions in the fields of physics and biophysics include development of advanced patient treatment planning software, feasibility studies of accelerator neutron source technology for Neutron Capture Therapy (NCT), and completion of major modifications to the research reactor at Washington State University to produce an epithermal-neutron beam for NCT research applications.

  9. INEEL Advanced Radiotherapy Research Program Annual Report 2001

    SciTech Connect

    Venhuizen, James R.

    2002-04-30

    This report summarizes the major activities and accomplishments of the Idaho National Engineering and Environmental Laboratory (INEEL) Advanced Radiotherapy Research Program for calendar year 2001. Applications of supportive research and development, as well as technology deployment in the fields of chemistry, radiation physics and dosimetry, and neutron source design and demonstration are described. Contributions in the fields of physics and biophysics include development of advanced patient treatment planning software, feasibility studies of accelerator neutron source technology for Neutron Capture Therapy (NCT), and completion of major modifications to the research reactor at Washington State University to produce an epithermal-neutron beam for NCT research applications.

  10. Accelerated Partial Breast Irradiation Using Only Intraoperative Electron Radiation Therapy in Early Stage Breast Cancer

    SciTech Connect

    Maluta, Sergio; Dall'Oglio, Stefano; Marciai, Nadia; Gabbani, Milena; Franchini, Zeno; Pietrarota, Paolo; Meliado, Gabriele; Guariglia, Stefania; Cavedon, Carlo

    2012-10-01

    Background: We report the results of a single-institution, phase II trial of accelerated partial breast irradiation (APBI) using a single dose of intraoperative electron radiation therapy (IOERT) in patients with low-risk early stage breast cancer. Methods and Materials: A cohort of 226 patients with low-risk, early stage breast cancer were treated with local excision and axillary management (sentinel node biopsy with or without axillary node dissection). After the surgeon temporarily reapproximated the excision cavity, a dose of 21 Gy using IOERT was delivered to the tumor bed, with a margin of 2 cm laterally. Results: With a mean follow-up of 46 months (range, 28-63 months), only 1 case of local recurrence was reported. The observed toxicity was considered acceptable. Conclusions: APBI using a single dose of IOERT can be delivered safely in women with early, low-risk breast cancer in carefully selected patients. A longer follow-up is needed to ascertain its efficacy compared to that of the current standard treatment of whole-breast irradiation.

  11. DOE - Office of Legacy Management -- Fernald Reports

    Office of Legacy Management (LM)

    Reports Fernald Preserve, Ohio Site Reports All reports below are Adobe Documents PDF Site Environmental Reports 2015 Site Environmental Report 2014 Site Environmental Report 2013 Site Environmental Report 2012 Site Environmental Report 2011 Site Environmental Report 2010 Site Environmental Report 2009 Site Environmental Report 2008 Site Environmental Report 2007 Site Environmental Report 2006 Site Environmental Report 2005 Site Environmental Report 2004 Site Environmental Report Inspection

  12. Updated Reporting Requirement Checklists and Research Performance...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Reporting Requirement Checklists and Research Performance Progress Report (RPPR) Updated Reporting Requirement Checklists and Research Performance Progress Report (RPPR) Policy ...

  13. Malfunctions of Implantable Cardiac Devices in Patients Receiving Proton Beam Therapy: Incidence and Predictors

    SciTech Connect

    Gomez, Daniel R., E-mail: dgomez@mdanderson.org [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Poenisch, Falk [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Pinnix, Chelsea C. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Sheu, Tommy [Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Chang, Joe Y. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Memon, Nada [Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Mohan, Radhe [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Rozner, Marc A. [Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Dougherty, Anne H. [Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2013-11-01

    Purpose: Photon therapy has been reported to induce resets of implanted cardiac devices, but the clinical sequelae of treating patients with such devices with proton beam therapy (PBT) are not well known. We reviewed the incidence of device malfunctions among patients undergoing PBT. Methods and Materials: From March 2009 through July 2012, 42 patients with implanted cardiac implantable electronic devices (CIED; 28 pacemakers and 14 cardioverter-defibrillators) underwent 42 courses of PBT for thoracic (23, 55%), prostate (15, 36%), liver (3, 7%), or base of skull (1, 2%) tumors at a single institution. The median prescribed dose was 74 Gy (relative biological effectiveness; range 46.8-87.5 Gy), and the median distance from the treatment field to the CIED was 10 cm (range 0.8-40 cm). Maximum proton and neutron doses were estimated for each treatment course. All CIEDs were checked before radiation delivery and monitored throughout treatment. Results: Median estimated peak proton and neutron doses to the CIED in all patients were 0.8 Gy (range 0.13-21 Gy) and 346 Sv (range 11-1100 mSv). Six CIED malfunctions occurred in 5 patients (2 pacemakers and 3 defibrillators). Five of these malfunctions were CIED resets, and 1 patient with a defibrillator (in a patient with a liver tumor) had an elective replacement indicator after therapy that was not influenced by radiation. The mean distance from the proton beam to the CIED among devices that reset was 7.0 cm (range 0.9-8 cm), and the mean maximum neutron dose was 655 mSv (range 330-1100 mSv). All resets occurred in patients receiving thoracic PBT and were corrected without clinical incident. The generator for the defibrillator with the elective replacement indicator message was replaced uneventfully after treatment. Conclusions: The incidence of CIED resets was about 20% among patients receiving PBT to the thorax. We recommend that PBT be avoided in pacing-dependent patients and that patients with any type of CIED receiving

  14. 2001 FEMP Customer Survey Report (Main Report) | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Main Report) 2001 FEMP Customer Survey Report (Main Report) This summary presents the key findings and recommendations from the 2001 FEMP customer survey. The key findings presented in this summary are a condensed presentation of the more detailed findings presented in each of the chapters. Study Report (2.32 MB) More Documents & Publications 2001 FEMP Customer Survey Report (Summary

  15. Annual Reports | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Annual Reports Annual Reports Annual Reports December 31, 2015 Southeastern Power Administration 2015 Annual Report This report reflects our agency's programs,accomplishments, operational, and financial activities for the 12-month period beginning October 1, 2014, and ending September 30, 2015. December 30, 2014 Southeastern Power Administration 2014 Annual Report This report reflects our agency's programs,accomplishments, operational, and financial activities for the 12-month period beginning

  16. Replanning During Intensity Modulated Radiation Therapy Improved Quality of Life in Patients With Nasopharyngeal Carcinoma

    SciTech Connect

    Yang Haihua; Hu Wei; Wang Wei; Chen Peifang; Ding Weijun; Luo Wei

    2013-01-01

    Purpose: Anatomic and dosimetric changes have been reported during intensity modulated radiation therapy (IMRT) in patients with nasopharyngeal carcinoma (NPC). The purpose of this study was to evaluate the effects of replanning on quality of life (QoL) and clinical outcomes during the course of IMRT for NPC patients. Methods and Materials: Between June 2007 and August 2011, 129 patients with NPC were enrolled. Forty-three patients received IMRT without replanning, while 86 patients received IMRT replanning after computed tomography (CT) images were retaken part way through therapy. Chinese versions of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30 and Head and Neck Quality of Life Questionnaire 35 were completed before treatment began and at the end of treatment and at 1, 3, 6, and 12 months after the completion of treatment. Overall survival (OS) data were compared using the Kaplan-Meier method. Results: IMRT replanning had a profound impact on the QoL of NPC patients, as determined by statistically significant changes in global QoL and other QoL scales. Additionally, the clinical outcome comparison indicates that replanning during IMRT for NPC significantly improved 2-year local regional control (97.2% vs 92.4%, respectively, P=.040) but did not improve 2-year OS (89.8% vs 82.2%, respectively, P=.475). Conclusions: IMRT replanning improves QoL as well as local regional control in patients with NPC. Future research is needed to determine the criteria for replanning for NPC patients undergoing IMRT.

  17. Monte Carlo and analytical model predictions of leakage neutron exposures from passively scattered proton therapy

    SciTech Connect

    Prez-Andjar, Anglica [Department of Radiation Physics, Unit 1202, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030 (United States)] [Department of Radiation Physics, Unit 1202, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030 (United States); Zhang, Rui; Newhauser, Wayne [Department of Radiation Physics, Unit 1202, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030 and The University of Texas Graduate School of Biomedical Sciences at Houston, 6767 Bertner Avenue, Houston, Texas 77030 (United States)] [Department of Radiation Physics, Unit 1202, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030 and The University of Texas Graduate School of Biomedical Sciences at Houston, 6767 Bertner Avenue, Houston, Texas 77030 (United States)

    2013-12-15

    Purpose: Stray neutron radiation is of concern after radiation therapy, especially in children, because of the high risk it might carry for secondary cancers. Several previous studies predicted the stray neutron exposure from proton therapy, mostly using Monte Carlo simulations. Promising attempts to develop analytical models have also been reported, but these were limited to only a few proton beam energies. The purpose of this study was to develop an analytical model to predict leakage neutron equivalent dose from passively scattered proton beams in the 100-250-MeV interval.Methods: To develop and validate the analytical model, the authors used values of equivalent dose per therapeutic absorbed dose (H/D) predicted with Monte Carlo simulations. The authors also characterized the behavior of the mean neutron radiation-weighting factor, w{sub R}, as a function of depth in a water phantom and distance from the beam central axis.Results: The simulated and analytical predictions agreed well. On average, the percentage difference between the analytical model and the Monte Carlo simulations was 10% for the energies and positions studied. The authors found that w{sub R} was highest at the shallowest depth and decreased with depth until around 10 cm, where it started to increase slowly with depth. This was consistent among all energies.Conclusion: Simple analytical methods are promising alternatives to complex and slow Monte Carlo simulations to predict H/D values. The authors' results also provide improved understanding of the behavior of w{sub R} which strongly depends on depth, but is nearly independent of lateral distance from the beam central axis.

  18. WE-A-BRD-01: Innovation in Radiation Therapy Planning I: Knowledge Guided Treatment Planning

    SciTech Connect

    Wu, Q; Olsen, L

    2014-06-15

    Intensity modulated radiation therapy (IMRT) and Volumetric Modulated Arc Therapy (VMAT) offer the capability of normal tissues and organs sparing. However, the exact amount of sparing is often unknown until the plan is complete. This lack of prior guidance has led to the iterative, trial and-error approach in current planning practice. Even with this effort the search for patient-specific optimal organ sparing is still strongly influenced by planner's experience. While experience generally helps in maximizing the dosimetric advantages of IMRT/VMAT, there have been several reports showing unnecessarily high degree of plan quality variability at individual institutions and amongst different institutions, even with a large amount of experience and the best available tools. Further, when physician and physicist evaluate a plan, the dosimetric quality of the plan is often compared with a standard protocol that ignores individual patient anatomy and tumor characteristic variations. In recent years, developments of knowledge models for clinical IMRT/VMAT planning guidance have shown promising clinical potentials. These knowledge models extract past expert clinical experience into mathematical models that predict dose sparing references at patient-specific level. For physicians and planners, these references provide objective values that reflect best achievable dosimetric constraints. For quality assurance, applying patient-specific dosimetry requirements will enable more quantitative and objective assessment of protocol compliance for complex IMRT planning. Learning Objectives: Modeling and representation of knowledge for knowledge-guided treatment planning. Demonstrations of knowledge-guided treatment planning with a few clinical caanatomical sites. Validation and evaluation of knowledge models for cost and quality effective standardization of plan optimization.

  19. Heating Oil and Propane Update - Revision report

    Gasoline and Diesel Fuel Update

    Revision reports Revision report 2015-2016 Revision report 2014-2015

  20. 2010 Site Environmental Report

    SciTech Connect

    Ratel, K.; Lee, R; Remien, J; Hooda, B; Green, T; Williams, J; Pohlot, P; Dorsch, W; Paquette, D; Burke, J

    2011-10-01

    Brookhaven National Laboratory (BNL) prepares an annual Site Environmental Report (SER) in accordance with DOE Order 231.1A, Environment, Safety and Health Reporting of the U.S. Department of Energy. The report is written to inform the public, regulators, employees, and other stakeholders of the Laboratory's environmental performance during the calendar year in review. Volume I of the SER summarizes environmental data; environmental management performance; compliance with applicable DOE, federal, state, and local regulations; and performance in restoration and surveillance monitoring programs. BNL has prepared annual SERs since 1971 and has documented nearly all of its environmental history since the Laboratory's inception in 1947. Volume II of the SER, the Groundwater Status Report, also is prepared annually to report on the status of and evaluate the performance of groundwater treatment systems at the Laboratory. Volume II includes detailed technical summaries of groundwater data and its interpretation, and is intended for internal BNL users, regulators, and other technically oriented stakeholders. A brief summary of the information contained in Volume II is included in Chapter 7, Groundwater Protection, of this volume. Both reports are available in print and as downloadable files on the BNL web page at http://www.bnl.gov/ewms/ser/. An electronic version on compact disc is distributed with each printed report. In addition, a summary of Volume I is prepared each year to provide a general overview of the report, and is distributed with a compact disc containing the full report. BNL is operated and managed for DOE's Office of Science by Brookhaven Science Associates (BSA), a partnership formed by Stony Brook University and Battelle Memorial Institute. For more than 60 years, the Laboratory has played a lead role in the DOE Science and Technology mission and continues to contribute to the DOE missions in energy resources, environmental quality, and national security

  1. International petroleum statistics report

    SciTech Connect

    1997-05-01

    The International Petroleum Statistics Report is a monthly publication that provides current international oil data. This report is published for the use of Members of Congress, Federal agencies, State agencies, industry, and the general public. Publication of this report is in keeping with responsibilities given the Energy Information Administration in Public Law 95-91. The International Petroleum Statistics Report presents data on international oil production, demand, imports, and stocks. The report has four sections. Section 1 contains time series data on world oil production, and on oil demand and stocks in the Organization for Economic Cooperation and Development (OECD). This section contains annual data beginning in 1985, and monthly data for the most recent two years. Section 2 presents an oil supply/demand balance for the world. This balance is presented in quarterly intervals for the most recent two years. Section 3 presents data on oil imports by OECD countries. This section contains annual data for the most recent year, quarterly data for the most recent two quarters, and monthly data for the most recent twelve months. Section 4 presents annual time series data on world oil production and oil stocks, demand, and trade in OECD countries. World oil production and OECD demand data are for the years 1970 through 1995; OECD stocks from 1973 through 1995; and OECD trade from 1985 through 1995.

  2. Technical progress report

    SciTech Connect

    1996-10-01

    This report summarizes experimental and theoretical work in basic nuclear physics carried out between October 1, 1995, the closing of our last Progress Report, and September 30, 1996 at the Nuclear Physics Laboratory of the University of Colorado, Boulder, under contracts DE-FG03-93ER-40774 and DE-FG03-95ER-40913 with the United States Department of Energy. The experimental contract supports broadly-based experimental research in intermediate energy nuclear physics. This report includes results from studies of Elementary Systems involving the study of the structure of the nucleon via polarized high-energy positron scattering (the HERMES experiment) and lower energy pion scattering from both polarized and unpolarized nucleon targets. Results from pion- and kaon-induced reactions in a variety of nuclear systems are reported under the section heading Meson Reactions; the impact of these and other results on understanding the nucleus is presented in the Nuclear Structure section. In addition, new results from scattering of high-energy electrons (from CEBAF/TJNAF) and pions (from KEK) from a broad range of nuclei are reported in the section on Incoherent Reactions. Finally, the development and performance of detectors produced by the laboratory are described in the section titled Instrumentation.

  3. 2004 SITE ENVIRONMENTAL REPORT

    SciTech Connect

    BROOKHAVEN NATIONAL LABORATORY; SER TEAM; ENVIRONMENTAL INFORMATION MANAGEMENT SERVICES GROUP; ENVIROMENTAL AND WASTE MANAGEMENT SERVICES DIVISION FIELD SAMPLING TEAM

    2005-08-22

    Each year, Brookhaven National Laboratory (BNL) prepares an annual Site Environmental Report (SER) in accordance with DOE Order 231.1A, Environment, Safety and Health Reporting of the U.S. Department of Energy (DOE). The SER is written to inform the public, regulators, Laboratory employees, and other stakeholders of BNL's environmental performance during the calendar year in review. The report summarizes BNL's environmental data; environmental management performance; compliance with applicable DOE, federal, state, and local regulations; and restoration and surveillance monitoring programs. BNL has prepared annual SERs since 1971 and has documented nearly all of its environmental history since the Laboratory's inception in 1947. The SER is intended to be a technical document. It is available in print and as a downloadable file on the BNL web page at http://www.bnl.gov/esd/SER.htm. A summary of the SER is also prepared each year to provide a general overview of the report, and is distributed with a CD version of the full report. The summary supports BNL's educational and community outreach program.

  4. Report to Congress on abnormal occurrences, January--March 1990

    SciTech Connect

    Not Available

    1990-07-01

    Section 208 of the Energy Reorganization Act of 1974 identifies an abnormal occurrence as an unscheduled incident or event that the Nuclear Regulatory Commission determines to be significant from the standpoint of public health or safety and requires a quarterly report of such events to be made to Congress. This report covers the period from January 1 through March 31, 1990. for this reporting period, there were 10 abnormal occurrences. One involved the loss of vital ac power with a subsequent reactor coolant system heat-up at the Vogtle Unit 1 nuclear power plant during shutdown. The event was investigated by an NRC Incident Investigation Team (IIT). The other nine abnormal occurrences involved nuclear material licensees and are described in detail under other NRC-issued licenses: eight of these involved medical therapy misadministrations; the other involved the receipt of an unshielded radioactive source at Amersham Corporation in Burlington, Massachusetts. The latter event was also investigated by an NRC IIT. No abnormal occurrences were reported by the Agreement States. The report also contains information that updates a previously reported abnormal occurrence.

  5. SU-E-T-62: Cardiac Toxicity in Dynamic Conformal Arc Therapy, Intensity-Modulated Radiation Therapy and Volumetric Modulated Arc Therapy of Lung Cancers

    SciTech Connect

    Ming, X; Zhang, Y; Feng, Y; Zhou, L; Deng, J

    2014-06-01

    Purpose: The cardiac toxicity for lung cancer patients, each treated with dynamic conformal arc therapy (DAT), intensity-modulated radiation therapy (IMRT), or volumetric modulated arc therapy (VMAT) is investigated. Methods: 120 lung patients were selected for this study: 25 treated with DAT, 50 with IMRT and 45 with VMAT. For comparison, all plans were generated in the same treatment planning system, normalized such that the 100% isodose lines encompassed 95% of planning target volume. The plan quality was evaluated in terms of homogeneity index (HI) and 95% conformity index (%95 CI) for target dose coverage and mean dose, maximum dose, V{sub 30} Gy as well as V{sub 5} Gy for cardiac toxicity analysis. Results: When all the plans were analyzed, the VMAT plans offered the best target coverage with 95% CI = 0.992 and HI = 1.23. The DAT plans provided the best heart sparing with mean heart dose = 2.3Gy and maximum dose = 11.6Gy, as compared to 5.7 Gy and 31.1 Gy by IMRT as well as 4.6 Gy and 30.9 Gy by VMAT. The mean V30Gy and V5Gy of the heart in the DAT plans were up to 11.7% lower in comparison to the IMRT and VMAT plans. When the tumor volume was considered, the VMAT plans spared up to 70.9% more doses to the heart when the equivalent diameter of the tumor was larger than 4cm. Yet the maximum dose to the heart was reduced the most in the DAT plans with up to 139.8% less than that of the other two plans. Conclusion: Overall, the VMAT plans achieved the best target coverage among the three treatment modalities, and would spare the heart the most for the larger tumors. The DAT plans appeared advantageous in delivering the least maximum dose to the heart as compared to the IMRT and VMAT plans.

  6. EIA-Voluntary Reporting of Greenhouse Gases Program - Why Report

    Energy Information Administration (EIA) (indexed site)

    Reporting of Greenhouse Gases Program Why Report What Is the Purpose of Form EIA-1605? Form EIA-1605 provides the means for the voluntary reporting of greenhouse gas emissions, ...

  7. Beam director design report

    SciTech Connect

    Younger, F.C.

    1986-08-01

    A design and fabrication effort for a beam director is documented. The conceptual design provides for the beam to pass first through a bending and focusing system (or ''achromat''), through a second achromat, through an air-to-vacuum interface (the ''beam window''), and finally through the vernier steering system. Following an initial concept study for a beam director, a prototype permanent magnet 30/sup 0/ beam-bending achromat and prototype vernier steering magnet were designed and built. In volume II, copies are included of the funding instruments, requests for quotations, purchase orders, a complete set of as-built drawings, magnetic measurement reports, the concept design report, and the final report on the design and fabrication project. (LEW)

  8. Refinery Capacity Report

    Reports and Publications

    2016-01-01

    Data series include fuel, electricity, and steam purchased for consumption at the refinery; refinery receipts of crude oil by method of transportation; and current and projected atmospheric crude oil distillation, downstream charge, and production capacities. Respondents are operators of all operating and idle petroleum refineries (including new refineries under construction) and refineries shut down during the previous year, located in the 50 states, the District of Columbia, Puerto Rico, the Virgin Islands, Guam, and other U.S. possessions. The Refinery Capacity Report does not contain working and shell storage capacity data. This data is now being collected twice a year as of March 31 and September 30 on the Form EIA-810, "Monthly Refinery Report", and is now released as a separate report Working and Net Available Shell Storage Capacity.

  9. Final Technical Report

    SciTech Connect

    Maxwell, Mike, J., P.E.

    2012-08-30

    The STI product is the Final Technical Report from ReliOn, Inc. for contract award DE-EE0000487: Recovery Act PEM Fuel Cell Systems Providing Emergency Reserve and Backup Power. The program covered the turnkey deployment of 431 ReliOn fuel cell systems at 189 individual sites for AT&T and PG&E with ReliOn functioning as the primary equipment supplier and the project manager. The Final Technical Report provides an executive level summary, a comparison of the actual accomplishments vs. the goals and objectives of the project, as well as a summary of the project activity from the contract award date of August 1, 2009 through the contract expiration date of December 31, 2011. Two photos are included in the body of the report which show hydrogen storage and bulk hydrogen refueling technologies developed as a result of this program.

  10. HPC Workshop Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    HPSS in the Extreme Scale Era (2018-2022): Report of the Extreme Scale Workshop July 15, 2009 | Download File: HPSSExtremeScaleFINALpublic.pdf | pdf | 1.6 MB This paper, from a workshop held at the National Energy Research Scientific Computing (NERSC) Facility in Oakland, CA, on July 14-15, 2009, is a report on the feasibility of using HPSS into the Extreme Scale era of storage (2018 - 2022). Workshop Participants: Danny Cook, LANL; Jason Hick, LBNL (chair); Jim Minton, LLNL; Henry Newman,

  11. PPPL Site Environmental Report

    SciTech Connect

    Virginia Finley, Robeert Sheneman and Jerry Levine

    2012-12-21

    Contained in the following report are data for radioactivity in the environment collected and analyzed by Princeton Plasma Physics Laboratorys Princeton Environmental, Analytical, and Radiological Laboratory (PEARL). The PEARL is located on?site and is certified for analyzing radiological and non?radiological parameters through the New Jersey Department of Environmental Protections Laboratory Certification Program, Certification Number 12471. Non?radiological surface and ground water samples are analyzed by NJDEP certified subcontractor laboratories QC, Inc. and Accutest Laboratory. To the best of our knowledge, these data, as contained in the Annual Site Environmental Report for 2011, are documented and certified to be correct.

  12. SPEAR 3 Quarterly Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    through December 2000 TABLE OF CONTENTS A. Project Summary 1. Technical Progress 2. Cost Reporting B. Detailed Reports 1.1 Magnets & Supports 1.2 Vacuum System 1.3 Power Supplies 1.4 RF System 1.5 Instrumentation & Controls 1.6 Cable Plant 1.8 Facilities 2.1 Accelerator Physics 2.2 Environmental Health and Safety A. SPEAR 3 PROJECT SUMMARY 1. Technical Progress Some staff changes have occurred during this quarter as shown in the organization chart (Fig. A1). The Project Management

  13. SPEAR3 Quarterly Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    April through June 2000 TABLE OF CONTENTS A. Project Summary 1. Technical Progress 2. Cost Reporting B. Detailed Reports 1.1 Magnets & Supports 1.2 Vacuum System 1.3 Power Supplies 1.4 RF System 1.5 Instrumentation & Controls 1.6 Cable Plant 1.8 Facilities 2.1 Accelerator Physics 2.2 Environmental Safety & Health A. SPEAR 3 PROJECT SUMMARY 1. Technical Progress On June 13-14, 2000, a DOE (Lehman) review committee conducted the third construction management review of the SPEAR 3

  14. Site Environmental Report, 1993

    SciTech Connect

    Not Available

    1994-06-01

    The Site Environmental Report (SER) is prepared annually in accordance with DOE Order 5400.1, ``General Environmental Protection Program.`` This 1993 SER provides the general public as well as scientists and engineers with the results from the site`s ongoing Environmental Monitoring Program. Also included in this report is information concerning the site`s progress toward achieving full compliance with requirements set forth by DOE, US Environmental Protection Agency (USEPA), and Ohio EPA (OEPA). For some readers, the highlights provided in the Executive Summary may provide sufficient information. Many readers, however, may wish to read more detailed descriptions of the information than those which are presented here.

  15. Arundo Donax Analysis Report

    SciTech Connect

    Corrie I. Nichol, Ph.D.; Tyler L. Westover, Ph.D.

    2012-01-01

    This is a summary report of preliminary analysis conducted on Arundo Donax. Arundo Donax was received from Greenwood Resources via Portland General Electric. PGE plans to transition a coal-fired boiler to 100% biomass by 2020, and has partnered with EPRI and INL to conduct the necessary testing and development to understand what needs to take place to make this transition. Arundo Donax is a promising energy crop for biopower, and is as yet relatively untested and uncharacterized. The INL has begun initial characterization of this material, and this summary report presents the initial findings.

  16. TANK SPACE OPTIONS REPORT

    SciTech Connect

    WILLIS WL; AHRENDT MR

    2009-08-11

    Since this report was originally issued in 2001, several options proposed for increasing double-shell tank (DST) storage space were implemented or are in the process of implementation. Changes to the single-shell tank (SST) waste retrieval schedule, completion of DST space saving options, and the DST space saving options in progress have delayed the projected shortfall of DST storage space from the 2007-2011 to the 2018-2025 timeframe (ORP-11242, River Protection Project System Plan). This report reevaluates options from Rev. 0 and includes evaluations of new options for alleviating projected restrictions on SST waste retrieval beginning in 2018 because of the lack of DST storage space.

  17. Nuclear Innovation Workshops Report

    SciTech Connect

    Jackson, John Howard; Allen, Todd Randall; Hildebrandt, Philip Clay; Baker, Suzanne Hobbs

    2015-09-01

    The Nuclear Innovation Workshops were held at six locations across the United States on March 3-5, 2015. The data collected during these workshops has been analyzed and sorted to bring out consistent themes toward enhancing innovation in nuclear energy. These themes include development of a test bed and demonstration platform, improved regulatory processes, improved communications, and increased public-private partnerships. This report contains a discussion of the workshops and resulting themes. Actionable steps are suggested at the end of the report. This revision has a small amount of the data in Appendix C removed in order to avoid potential confusion.

  18. Waste management progress report

    SciTech Connect

    1997-06-01

    During the Cold War era, when DOE and its predecessor agencies produced nuclear weapons and components, and conducted nuclear research, a variety of wastes were generated (both radioactive and hazardous). DOE now has the task of managing these wastes so that they are not a threat to human health and the environment. This document is the Waste Management Progress Report for the U.S. Department of Energy dated June 1997. This progress report contains a radioactive and hazardous waste inventory and waste management program mission, a section describing progress toward mission completion, mid-year 1997 accomplishments, and the future outlook for waste management.

  19. Drum drop test report

    SciTech Connect

    McBeath, R.S.

    1995-02-28

    Testing was performed to determine actual damage to drums when dropped from higher than currently stacked elevations. The drum configurations were the same as they are placed in storage; single drums and four drums banded to a pallet. Maximum drop weights were selected based on successful preliminary tests. Material was lost from each of the single drum tests while only a small amount of material was lost from one of the pelletized drums. The test results are presented in this report. This report also provides recommendations for further testing to determine the appropriate drum weight which can be stored on a fourth tier.

  20. Audit Report: IG-0743

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Audit Services Audit Report 1 - &i Grounds at the Hanford Site October 2006 Department of Energy Washington, DC 20585 October 18, 2006 MEMOKilNDUM FOR THE SECRETARY FROM: reg ry . Friedman Ajakcl, Inspector General SIJBJ EC-1': INFORMATION: Audit Report on " Kemediatio~i of the Waste Burla1 Grounds at the Hanford Site" BACKGKOUN D In the lc!50's and 19601s, operations at the Department of Energy's Hanfortl. Washington Site gencr;ltcd large amounts of radioactive waste. tianford