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Sample records for nick braden appa

  1. APPA Customer Connections Conference

    Energy.gov [DOE]

    The Customer Connections Conference is APPA's annual meeting for utility professionals in the areas of:

  2. 2015 APPA National Conference

    Energy.gov [DOE]

    The American Public Power Association (APPA) is hosting their national conference that covers the political, economic, and technological trends shaping the electric utility industry.

  3. Nick Buraglio

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Nick Buraglio Engineering Services The Network OSCARS Fasterdata IPv6 Network Network Performance Tools The ESnet Engineering Team Contact Us Technical Assistance: 1 800-33-ESnet (Inside US) 1 800-333-7638 (Inside US) 1 510-486-7600 (Globally) 1 510-486-7607 (Globally) Report Network Problems: trouble@es.net Provide Web Site Feedback: info@es.net Nick Buraglio Nick Buraglio Network Engineer buraglio@es.net

  4. Nick Buraglio

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Nick Buraglio About ESnet Our Mission The Network ESnet History Governance & Policies Career Opportunities ESnet Staff & Org Chart ESnet Leadership Administration Advanced Network Technologies Cybersecurity Infrastructure, Identity & Collaboration Network Engineering Network Planning Operational Enhancements Office of the CTO Science Engagement Tools Team Contact Us Contact Us Technical Assistance: 1 800-33-ESnet (Inside US) 1 800-333-7638 (Inside US) 1 510-486-7600 (Globally) 1

  5. APPA Engineering and Operations Technical Conference

    Energy.gov [DOE]

    The 2014 APPA Engineering and Operations Technical Conference is designed for public power professionals charged with designing, developing, and maintaining the nation's electric system.

  6. Asociacion de Productores de Energias Renovables APPA | Open...

    OpenEI (Open Energy Information) [EERE & EIA]

    Productores de Energias Renovables APPA Jump to: navigation, search Name: Asociacion de Productores de Energias Renovables (APPA) Place: Spain Sector: Renewable Energy Product:...

  7. NickL's blog

    OpenEI (Open Energy Information) [EERE & EIA]

    Oct 2015 21:19:38 +0000 NickL 1717 at http:en.openei.orgcommunity The Upshot and Innovation of the Green Button Initiative http:en.openei.orgcommunityblog...

  8. Nick Sinai | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Nick Sinai About Us Nick Sinai - U.S. Deputy Chief Technology Officer, White House Office of Science and Technology Policy Nick Sinai is the U.S. Deputy CTO, White House Office of Science and Technology Policy and the former Energy and Environment Director for the Federal Communications Commission. Most Recent Expanded "Green Button" Will Reach Federal Agencies and More American Energy Consumers December 6 Green Button: Enabling Energy Innovation May 9 Better Building Federal Award

  9. NREL: Energy Analysis - Nick Grue

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Grue Nick Grue is a member of the Data Analysis and Visualization Group in the Strategic Energy Analysis Center. Scientist II - GIS On staff since June 2014 Phone number: 303-384-7278 E-mail: nick.grue@nrel.gov Areas of expertise Geospatial analysis Web GIS Primary research interests Open source energy data Web visualization of energy data Renewable energy policy Education and background training B.A. in geography and environmental science, University of Colorado at Denver, Denver, CO, 2012

  10. NREL: Energy Analysis - Nick Muerdter

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Muerdter Nick Muerdter is a member of the Data Analysis and Visualization Group in the Strategic Energy Analysis Center. Software Engineer Phone number: 303-275-4459 E-mail: Nick.Muerdter@nrel.gov Areas of expertise Online applications Data-driven websites Primary research interests Alternative vehicle fuels Education and background training B.S. in computer science, Rochester Institute of Technology, Rochester, NY Prior work experience Software Engineer Co-op, BlueTie, Rochester, NY Webmonkey,

  11. NREL: Energy Analysis - Nick Langle

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Langle Photo of Nick Langle. Nick Langle is a member of the Data Analysis and Visualization Group in the Strategic Energy Analysis Center. Front-End Web Engineer On staff since July 2010 Phone number: 303-275-3775 E-mail: nicholas.langle@nrel.gov Areas of expertise HTML/CSS/Javascript/jQuery UI/UX Responsive web design Semantic MediaWiki SEO Primary research interests Web design and usability Data visualization and analytics Geospatial analysis Transportation and alternative fuels Industrial

  12. Nick Wright Named Advanced Technologies Group Lead

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Nick Wright Named Advanced Technologies Group Lead Nick Wright Named Advanced Technologies Group Lead February 4, 2013 Nick Nick Wright has been named head of the National Energy Research Scientific Computing Center's (NERSC) Advanced Technologies Group (ATG), which focuses on understanding the requirements of current and emerging applications to make choices in hardware design and programming models that best serve the science needs of NERSC users. ATG specializes in benchmarking, system

  13. Rapporteurs Report: Tom Lograsso, Ames Laboratory and Nick Morley...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Rapporteurs Report: Tom Lograsso, Ames Laboratory and Nick Morley, Oakdene Hollins Rapporteurs Report: Tom Lograsso, Ames Laboratory and Nick Morley, Oakdene Hollins Microsoft...

  14. Mr. Nick Proto Ralph Ferrara, Inc.

    Office of Legacy Management (LM)

    Department of Energy Washington, DC 20585 Mr. Nick Proto Ralph Ferrara, Inc. 601 West 26th ... It is the policy of the Department of Energy to independently verify that remedial ...

  15. NREL: Photovoltaics Research - Nick Bosco, PhD

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Nick Bosco, PhD Senior Scientist Photo of vv 303-384-6337 Nick.Bosco@nrel.gov Task Focus: Failure Analysis and Accelerated Testing Specializes in: Infrared imaging and other...

  16. Lisa Gerhardt! Nick Balthaser! Storage Systems Group

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Nick Balthaser! Storage Systems Group Introduction to NERSC Archival Storage: HPSS --- 1 --- September 10, 2013 What is an archive? * Long---term storage of permanent records and informa9on - O%en d ata t hat i s n o l onger m odified o r r egularly a ccessed - Storage 8 me f rame i s i ndefinite o r a s l ong a s p ossible - Archive d ata t ypically h as, o r m ay h ave, l ong---term v alue t o t he organiza8on * NERSC a rchiving s ystem u ses H PSS ( high p erformance storage system) soFware *

  17. NCYM promotes calpain-mediated Myc-nick production in human MYCN-amplified neuroblastoma cells

    SciTech Connect

    Shoji, Wataru; Suenaga, Yusuke; Kaneko, Yoshiki; Islam, S.M. Rafiqul; Alagu, Jennifer; Yokoi, Sana; Nio, Masaki; Nakagawara, Akira

    2015-06-05

    NCYM is a cis-antisense gene of MYCN and is amplified in human neuroblastomas. High NCYM expression is associated with poor prognoses, and the NCYM protein stabilizes MYCN to promote proliferation of neuroblastoma cells. However, the molecular mechanisms of NCYM in the regulation of cell survival have remained poorly characterized. Here we show that NCYM promotes cleavage of MYCN to produce the anti-apoptotic protein, Myc-nick, both in vitro and in vivo. NCYM and Myc-nick were induced at G2/M phase, and NCYM knockdown induced apoptotic cell death accompanied by Myc-nick downregulation. These results reveal a novel function of NCYM as a regulator of Myc-nick production in human neuroblastomas. - Highlights: • NCYM promotes cleavages of MYC and MYCN to produce Myc-nick in vitro. • NCYM increases Myc-nick production in MYCN-amplified neuroblastoma cells. • NCYM knockdown decreases Myc-nick production and induces apoptosis at G2/M phase.

  18. Nick Buraglio

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Opportunities ESnet Staff & Org Chart Administration Advanced Network Technologies Cybersecurity Infrastructure, Identity & Collaboration Network Engineering Office of the CTO...

  19. app_a

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... Date Drawn : January 21, 1999 0 10 20 30 km 0 5 10 15 20 ... In accordance with 40 CFR 1501.2(b), DOE must "identify ... 4 Near Power Burst Facility 821 70 6 5 Near Test Reactor ...

  20. Nick Johnson | Department of Energy

    Energy.gov [DOE] (indexed site)

    Available | Department of Energy News Contact: DOE, Rich Bush, UMTRCA Program Lead (970) 248-6073 Contractor, Bob Darr, S.M. Stoller Corporation Public Affairs (720) 377-9672 Grand Junction, Colo. - The U.S. Department of Energy announces the availability of the 2010 Annual Site Inspection and Monitoring Report for Uranium Mill Tailings Radiation Control Act Title I Disposal Sites and the 2010 Annual Site Inspection and Monitoring Report for Uranium Mill Tailings Radiation Control Act Title

  1. Nick Balthaser! Storage Systems Group

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ser's h ome d irectory on t he c ompute p laiorm - All N ERSC H PSS c lients u se t he s ame . netrc fi le - The k ey i s I P s pecific. M ust g enerate a n ew k ey f or u se o...

  2. Nick's Utility | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Ownership F NERC Location WECC, MAPP NERC MRO Yes NERC SPP Yes NERC WECC Yes ISO CA Yes RTO SPP Yes ISO MISO Yes ISO Other Yes Activity Generation Yes Activity Transmission Yes...

  3. Nick Wright Named Advanced Technologies Group Lead

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    models that best serve the science needs of NERSC users. ATG specializes in benchmarking, system performance, debugging and analysis, workload monitoring, use of...

  4. NERSC Nick Balthaser NERSC Storage Systems Group

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... can use the same token - Tokens are username and IP specific-must generate a ... version for your hardwareOS (NERSC username password required) * Minor OS version ...

  5. NERSC Nick Balthaser NERSC Storage Systems Group

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    is backed by tape, robotics, and a single SQL database instance for metadata - Operations ... - Recursion - Command-line editing and history - Wildcards * Connecting to the archive: ...

  6. Microsoft Word - S08266_App_A-2.doc

    Office of Legacy Management (LM)

    tabernaemontani SOFT-STEMMED BULRUSH sedge 2 native OBL 5.912% Scirpus atrovirens GREEN BULRUSH sedge 1 native OBL 0.222% Sorghastrum nutans INDIAN GRASS grass 5 native UPL...

  7. Microsoft Word - S08266_App_A-3.doc

    Office of Legacy Management (LM)

    Score 0 Fernald Preserve, Ohio, Wetland Mitigation Monitoring Report U.S. Department of Energy Doc. No. S08266 Appendix A-3, 2011 Amphibian Index of Biotic Integrity Data...

  8. Lisa Gerhardt! NERSC User Services! Nick Balthaser! NERSC Storage Systems!

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    NUG Training! February 3, 2014 Introduction to NERSC Archival Storage: HPSS What is an archive? * Long---term data storage - O"en d ata t hat i s n o l onger m odified o r r egularly a ccessed - Storage 6 me f rame i s i ndefinite o r a s l ong a s p ossible - Archive d ata t ypically h as, o r m ay h ave, l ong---term v alue t o t he organiza6on * NERSC a rchiving s ystem u ses H PSS ( high p erformance storage system) so?ware * Typical u se c ases a t N ERSC i nclude: - Long---term s

  9. Lisa Gerhardt! NERSC User Services! Nick Balthaser! NERSC Storage...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... m ounts a nd p osi)oning ac)vity for best read performance --- 1 5 --- Size Matters * Sweet Spot - Tape d rives p erform b est w hen o pera9ng a t f ull r ate ("streaming") f or l ...

  10. Nick Balthaser! Wayne Hurlbert! LBNL/NERSC Storage Systems Group

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    o f 9 me i n p roduc9on - Drive f eatures i n u se * Data V olume - Carts, T B, fi les * Workload - Exchangesunit 9 me - IO R ates: R aw v s. H PSS * Error R ates * Data L...

  11. NickL's blog | OpenEI Community

    OpenEI (Open Energy Information) [EERE & EIA]

    held a mapathon, focused on three main projects: humanitarian mapping efforts, mapping U.S. parks, and power outage mapping. OpenEI provided support for the Power Utility Areas...

  12. Geek-Up[12.23.2010]: Muons at the South Pole and Dr. Nick Holoynak |

    Energy Saver

    - a,- p^A CU ^ ^JL\ CC6p^ w b A GREENING DOE HEADQUARTERS Office of Management, November 2008 The DOE Headquarters Forrestal and Germantown buildings have award-winning energy conservation and environmental quality programs focused on making our buildings as green as possible and, enabling them to serve as showcases for the entire Department. Both the Forrestal and the Germantown facilities have earned EPA's Energy Star designation, ranking them among the nation's top buildings in terms of

  13. Nick Balthaser! LBNL/NERSC Storage Systems Group LBNL/NERSC Site

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... Recent Challenges * GlobusOnlineHPSS IntegraJon - Tesng a nd d eployment o f N CSA GridFTPHPSS D SI f or H PSS 7 .3.3 * Tape A ggregates - File r etrieval: u nordered v ...

  14. Nick Balthaser! LBNL/NERSC Storage Systems Group GlobusOnline...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    b ut d isabled a Yer H PSS 7 .3 u pgrade 032013 - HPSS 7 .3.3 D SI d eveloped a t N CSA * nerschpss G O e ndpoint r e---enabled 0 92013 a Yer e xtensive r e---tesJng --- 3 ...

  15. Exploring the Business Link Opportunity: Transmission & Clean...

    Energy.gov [DOE] (indexed site)

    with WAPA: Braden Houston, Citizens Energy (503.08 KB) Western States' Renewable Portfolio Standards, Compliance Status, and Tribal Energy Opportunities: Sarah Busche, National ...

  16. In the Matter of National Broadband Plan Request for Information...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    The American Public Power Association ("APPA") appreciates ... Information ("RFI") on Implementing the National Broadband ... of Electric Utilities to Inform Federal Smart Grid Policy. ...

  17. The Honorable Ernest Moniz

    Energy.gov [DOE] (indexed site)

    Electric Cooperative Association (NRECA) and the American Public Power Association (APPA) together represent over 1,200 cooperative and publicly owned utilities in 34 states...

  18. Green Button Apps on OpenEI | OpenEI Community

    OpenEI (Open Energy Information) [EERE & EIA]

    Applications Login to post comments Dc's blog Latest blog posts NickL The Upshot and Innovation of the Green Button Initiative Posted: 22 Jul 2015 - 15:16 by NickL NickL DOE...

  19. Nicholas J. Nagle | Bioenergy | NREL

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Nicholas J. Nagle Nicholas J. Nagle Bioprocessing Engineer Nick.Nagle@nrel.gov | 303-384-6184 Research Interests Nick is interested in understanding how advanced feedstocks perform ...

  20. Questions about OpenEI? | OpenEI Community

    OpenEI (Open Energy Information) [EERE & EIA]

    posts NickL OpenEI Contacts Posted: 5 Oct 2015 - 14:19 by NickL NickL The Upshot and Innovation of the Green Button Initiative Posted: 22 Jul 2015 - 15:16 by NickL 1 of 206 ...

  1. DOE Releases New Wind Vision Report | OpenEI Community

    OpenEI (Open Energy Information) [EERE & EIA]

    posts NickL OpenEI Contacts Posted: 5 Oct 2015 - 14:19 by NickL NickL The Upshot and Innovation of the Green Button Initiative Posted: 22 Jul 2015 - 15:16 by NickL 1 of 206 ...

  2. Secret Energy Savings | OpenEI Community

    OpenEI (Open Energy Information) [EERE & EIA]

    posts NickL OpenEI Contacts Posted: 5 Oct 2015 - 14:19 by NickL NickL The Upshot and Innovation of the Green Button Initiative Posted: 22 Jul 2015 - 15:16 by NickL 1 of 206 ...

  3. Google lends support to the software behind OpenEI.org | OpenEI...

    OpenEI (Open Energy Information) [EERE & EIA]

    posts NickL OpenEI Contacts Posted: 5 Oct 2015 - 14:19 by NickL NickL The Upshot and Innovation of the Green Button Initiative Posted: 22 Jul 2015 - 15:16 by NickL 1 of 206 ...

  4. Nicholaos Demas | Argonne National Laboratory

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Nick Demas Nicholaos Demas Assistant Materials Scientist E-mail ndemas@anl.gov

  5. Advantages of Whole-liver Intensity Modulated Radiation Therapy in Children With Wilms Tumor and Liver Metastasis

    SciTech Connect

    Kalapurakal, John A.; Pokhrel, Damodar; Gopalakrishnan, Mahesh; Zhang, Yunkai

    2013-03-01

    Purpose: To demonstrate the dosimetric advantages of intensity modulated radiation therapy (IMRT) in children with Wilms tumor (WT) undergoing whole-liver (WL) RT. Methods and Materials: Computed tomography simulation scans of 10 children, either 3 (3D) or 4-dimensional (4D), were used for this study. The WL PTV was determined by the 3D or 4D liver volumes, with a margin of 1 cm. A total of 40 WL RT plans were performed: 10 each for left- and right-sided WT with IMRT and anteroposterior-posteroanterior (AP-PA) techniques. The radiation dose-volume coverage of the WL planning target volume (PTV), remaining kidney, and other organs were analyzed and compared. Results: The 95% dose coverage to WL PTV for left and right WT were as follows: 97% ± 4% (IMRT), 83% ± 8% (AP-PA) (P<.01) and 99% ± 1% (IMRT), 94% ± 5% (AP-PA) (P<.01), respectively. When 3D WL PTV was used for RT planning, the AP-PA technique delivered 95% of dose to only 78% ± 13% and 88% ± 8% of 4D liver volume. For left WT, the right kidney V15 and V10 for IMRT were 29% ± 7% and 55% ± 8%, compared with 61% ± 29% (P<.01) and 78% ± 25% (P<.01) with AP-PA. For right WT, the left kidney V15 and V10 were 0 ± 0 and 2% ± 3% for IMRT, compared with 25% ± 19% (P<.01) and 40% ± 31% (P<.01) for AP-PA. Conclusions: The use of IMRT and 4D treatment planning resulted in the delivery of a higher RT dose to the liver compared with the standard AP-PA technique. Whole-liver IMRT also delivered a significantly lower dose to the remaining kidney.

  6. geospatial data | OpenEI Community

    OpenEI (Open Energy Information) [EERE & EIA]

    geospatial data Home NickL's picture Submitted by NickL(137) Contributor 25 June, 2012 - 21:45 GIS keyword geospatial data GIS GIS data Explore the geospatial datasets in OpenEI's...

  7. GIS data | OpenEI Community

    OpenEI (Open Energy Information) [EERE & EIA]

    GIS data Home NickL's picture Submitted by NickL(137) Contributor 25 June, 2012 - 21:45 GIS keyword geospatial data GIS GIS data Explore the geospatial datasets in OpenEI's...

  8. Geospatial | OpenEI Community

    OpenEI (Open Energy Information) [EERE & EIA]

    Blog entry Discussion Document Event Poll Question Keywords Author Apply NickL Hi-Yes, you are correct wi... Posted by: NickL 10 Sep 2013 - 10:02 Hi- Yes, you are correct...

  9. A question about geographic data on wind farms in the US | OpenEI...

    OpenEI (Open Energy Information) [EERE & EIA]

    know. Thanks -nick Submitted by Nickc on 10 September, 2013 - 11:52 1 answer Points: 0 Hi Nick- Thank you for posting your question here. One of the most complete wind farm...

  10. Databus | OpenEI Community

    OpenEI (Open Energy Information) [EERE & EIA]

    Blog entry Discussion Document Event Poll Question Keywords Author Apply NickL Hello-Sorry for the delay in... Posted by: NickL 22 Sep 2015 - 14:33 Hello- Sorry for the...

  11. FRED Overview Slides | OpenEI Community

    OpenEI (Open Energy Information) [EERE & EIA]

    hybrid power plants? Login to post comments NickL NickL2 years 39 weeks ago Wind Data Hello- There are various types of wind data available. These can be searched for on OpenEI...

  12. Green Button FAQ | OpenEI Community

    OpenEI (Open Energy Information) [EERE & EIA]

    Green Button FAQ Home > Groups > Green Button Applications NickL's picture Submitted by NickL(137) Contributor 21 July, 2014 - 10:02 Green Button The greenbuttondata.org site has...

  13. ERC commercialization activities

    SciTech Connect

    1995-08-01

    The ERC family of companies is anticipating market entry of their first commercial product, a 2.8-MW power plant, in the second quarter of 1999. The present Cooperative Agreement provides for: (1) Commercialization planning and organizational development, (2) Completion of the pre-commercial DFC technology development, (3) Systems and plant design, (4) Manufacturing processes` scale-up to full-sized stack components and assemblies, (5) Upgrades to ERC`s test facility for full-sized stack testing, (6) Sub-scale testing of a DFC Stack and BOP fueled with landfill gas. This paper discusses the first item, that of preparing for commercialization. ERC`s formal commercialization program began in 1990 with the selection of the 2-MW Direct Fuel Cell power plant by the American Public Power Association (APPA) for promotion to the over 2000 municipal utilities comprising APPA`s segment of the utility sector. Since that beginning, the APPA core group expanded to become the Fuel Cell Commercialization Group (FCCG) which includes representation from all markets - utilities and other power generation equipment buyers.

  14. February 10, 2010 - Public Power Open Session

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Industrial Utility Webinars February 10, 2010 Industrial Technologies Program eere.energy.gov Areas Covered in this Webinar * Working with public power utilities * Designing programs specific to public power * Working with state mandates * Leveraging federal government resources Speakers * Ed Carroll, Franklin Energy * Dean Laube, Franklin Energy * Kevin Martin, Danville Utilities Sponsors * DOE Industrial Technologies Program * American Public Power Association * APPA, Demonstration of

  15. DOE FINAL TECHNICAL REPORT RP

    SciTech Connect

    RUSS PETERMAN

    2012-01-01

    The City of Georgetown Utility Systems (GUS) patnered with the private sector, the American Public Power Association (APPA) and Southwestern University to design, construct, test and monitor a solar co-generation system directly connected to the GUS electric distribution system. This report consists of the Primary Technical Report and 3 attachments.

  16. Mistissini

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Citizens Energy Corporation Interconnection with WAPA Braden Houston Director of Project Development Citizens Energy February 7, 2012 CITIZENS ENERGY CORPORATION a non-profit energy company Citizens Energy Corporation Not for Distribution Confidential & Proprietary * Non-profit energy company founded by Joseph P. Kennedy II in 1979 - U.S. Congressman 1986-1998 - Citizens Energy * Chairman & CEO - 1979-1986 - 1998-Present - Son of Robert F. (Bobby) Kennedy Citizens Energy Corporation

  17. Wastewater Reclamation and Biofuel Production Using Algae

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Wastewater Reclamation and Biofuel Production Using Algae Tryg Lundquist, Ph.D., P.E., Presenter Ian Woertz, Matt Hutton, Ruth Spierling, Shelley Blackwell, Braden Crowe Bioenergy | June 24, 2015 | Washington DC 1 California Polytechnic State University San Luis Obispo, California MicroBio Engineering, Inc. San Luis Obispo, California * 2014 US DOE Algae Biomass Yield Project * 2013 US DOE Water & Nutrient Recycling Project * 2013 US DOE ATP 3 Testbed Site (Prime: ASU) * 2011 CEC Algae

  18. HANFORD ADVISORY BOARD

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... from the Environmental Protection Agency (EPA) on the State of the Columbia River. ... Agency perspective Nick Ceto, Environmental Protection Agency (EPA), thought the advice is ...

  19. Hanford Site Contractor Receives Overall 'Very Good' Rating for...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ... Also pictured are, from left to right, Dave Olson, WRPS president and project manager; Jennie Weber, ESD's eastern regional director; and Nick Erickson, the local veterans' ...

  20. EM Newsletters | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Dave Olson, WRPS president and project manager; Jennie Weber, ESD's eastern regional director; and Nick Erickson, the local veterans' employment representative. State Honors...

  1. GIS keyword | OpenEI Community

    OpenEI (Open Energy Information) [EERE & EIA]

    Open government map data initiatives in the USA or Canada? IRENA launches global atlas of renewable energy potential more Group members (8) Managers: NickL Recent members:...

  2. United Nations Environment Programme (UNEP)-Finance Initiative...

    OpenEI (Open Energy Information) [EERE & EIA]

    Generale (France) Standard Chartered (United Kingdom) Sustainable Asset Management (SAM) (Switzerland) SwissRe (Switzerland) UBS (Switzerland) Chairs Nick Robins, HSBC...

  3. Nicholas Balthaser

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    analyst at Wells Fargo Bank. Before joining the Storage Systems Group Nick managed Linux compute platforms in the Computational Systems Group and administered FreeBSD systems...

  4. TITLE AUTHORS SUBJECT SUBJECT RELATED DESCRIPTION PUBLISHER AVAILABILI...

    Office of Scientific and Technical Information (OSTI)

    Deep Bed Adsorption Testing using Silver Functionalized Aerogel Nick Soelberg Tony Watson MGMT OF RADIOACTIVE AND NON RADIOACTIVE WASTES FROM NUCLEAR FACILITIES aerogel iodine...

  5. Deep Bed Adsorption Testing using Silver-Functionalized Aerogel...

    Office of Scientific and Technical Information (OSTI)

    Bed Adsorption Testing using Silver-Functionalized Aerogel Nick Soelberg; Tony Watson 12 MGMT OF RADIOACTIVE AND NON-RADIOACTIVE WASTES FROM NUCLEAR FACILITIES aerogel; iodine...

  6. ARM - Facility News Article

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    in a first person view, using curiosity as their guide. Vivid Learning Systems' Nick Bauer takes stills on top of the Radiometric Calibration Facility. Vivid Learning Systems'...

  7. Operated by Los Alamos National Security, LLC for NNSA U N C...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    John Morrison Nick Nagy Randal Rheinheimer Norbert Seifert Randy Smith Bob Tomlinson Philip Ulibarri Mark Vernon Andy White ... Operated by Los Alamos National Security, LLC for...

  8. Mark Caffarey, UMICORE, "Opportunities and Limits to Recycling...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    icon SessionC4Caffarey.ppt More Documents & Publications Rapporteurs Report: Tom Lograsso, Ames Laboratory and Nick Morley, Oakdene Hollins 2010 Critical Materials...

  9. Cosmological Simulations for Sky Surveys

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Nick Gnedin (FNAL), Katrin Heitmann (ANL), David Higdon (LANL), Peter Nugent (LBNL), Rob Ross (ANL), Anze Slosar (BNL), Risa Wechsler (SLAC), Martin White (UC Berkeley) NERSC...

  10. NREL: Photovoltaics Research - Materials Applications and Performance...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Patricia Kline Administrative Professional Nick Bosco Michael Deceglie Chris Deline Peter Hacke Dirk Jordan Michael Kempe Sara MacAlpine William Marion David Miller Matt Muller ...

  11. Search for: All records | DOE PAGES

    Office of Scientific and Technical Information (OSTI)

    T. ; Posewitz, Matthew C. May 2015 , Elsevier Combined algal processing: A novel ... Nick Full Text Available January 2016 , Elsevier The effects of physical and chemical ...

  12. Organizational Chart

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    John Shalf Jeff Broughton Katie Antypas Jay Srinivasan Nick Wright Brent Draney Elizabeth Bautista Shane Cannon Prabhat David Skinner Richard Gerber Damian Hazen Last edited:...

  13. TransportToolkit Prototype | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    AgencyCompany Organization: Nick Langle ComplexityEase of Use: Not Available Cost: Free Transport Toolkit Region(s): Asia, Europe, Africa & Middle East, Australia & North...

  14. Apps for Energy Challenge | OpenEI Community

    OpenEI (Open Energy Information) [EERE & EIA]

    winners from the challenge are listed among the featured apps. Public voting is still open. Groups: Green Button Applications Login to post comments Latest discussions NickL...

  15. Statement from Energy Secretary Samuel W. Bodman on the Introduction of Legislation to Expand the SPR

    Energy.gov [DOE]

    "I commend Senator Thad Cochran and Congressmen Ralph Hall, Joe Barton, Nick Lampson, and Chip Pickering for introducing legislation today to increase the capacity of the Strategic Petroleum...

  16. PowerPoint Presentation

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Meet the Challenge Team Nay Chehab Communications Lead Carrie Giles & Carrie Ryder Recruitment and Account Management Peter Heywood Ambassador Lead Sarah Olexsak Coordinator Nick ...

  17. QER- Comment of American Public Power Association 1

    Office of Energy Efficiency and Renewable Energy (EERE)

    Attached are the American Public Power Association 's (APPA) statement for the April 11 QER public meeting, Duane Highley's statement for the same meeting since we reference it, and Sue Kelly's (APPA President & CEO) testimony from last Thursday's (April 10) Senate Energy and Natural Resources Committee hearing entitled "Keeping the Lights On – Are We Doing Enough to Ensure the Reliability and Security of the US Electric Grid?" since her testimony covers everything in regards to this meeting. Thank you in advance for your consideration of our attached documents for the QER. Please let me know if you have any questions. Best, Seth Seth Voyles Director, Government Relations 1875 Connecticut Ave., NW, Suite 1200, Washington, D.C. 20009-5715 www.publicpower.org

  18. Student Spotlight

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    spotlight Student Spotlight Mekena McGrew Single-shot, Second Harmonic Generation Frequency Resolved Optical Gating (SHG FROG) system for damage testing. Nick Zobrist Optics inspection algorithms that evaluate the condition of NIF's optics. Maverick Chea Optimization of Ultrathin Films Alexandra Carlson Image Analysis Classification algorithm to automatically classify NIF optics damage sites. Nick Czapla Characterizing Scatter Plate Material

  19. Building Re-tuning Training | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Re-tuning Training Building Re-tuning Training Lead Performer: Pacific Northwest National Laboratory (PNNL) - Richland, WA Partners: -- Building Owners and Managers Association (BOMA) -- APPA: Leadership in Educational Facilities -- Pennsylvania State University - Philadelphia, PA FY16 DOE Funding: $25,000 Project Term: October 1, 2011 - September 30, 2016 Funding Type: Direct Lab Funding Project Website: https://www4.eere.energy.gov/workforce/projects/buildings-retuning-training PROJECT

  20. Microsoft Word - NAP Coalition Response to DOE RFI DRAFT 10.11.01.docx

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    NAP Coalition Response to DOE RFI Addressing Policy and Logistical Challenges to Smart Grid Implementation November 1, 2010 The NAP Coalition is a "Coalition of Coalitions" that has been formed for the purpose of implementing the National Action Plan released by FERC in cooperation with DOE in June of 2010. Organizations working together on NAP implementation in include EEI, APPA, NRECA, ASE, ACEEE, NASUCA, NARUC, NASEO, DRSG, DRCC and EDF. The NAP Coalition submits a response in this

  1. Energy Bill Literature Sources

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    of the "PURPA Standards" in the Energy Independence and Security Act of 2007 August 11, 2008 Sponsored by American Public Power Association (APPA) Edison Electric Institute (EEI) National Association of Regulatory Utility Commissioners (NARUC) National Rural Electric Cooperative Association (NRECA) Prepared by: Kenneth Rose and Mike Murphy iii Preface This manual was prepared by Kenneth Rose, a consultant and Senior Fellow at the Institute of Public Utilities at Michigan State

  2. Energy Bill Literature Sources

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Of the "PURPA Standards" in the Energy Policy Act of 2005 March 22, 2006 Sponsored by American Public Power Association (APPA) Edison Electric Institute (EEI) National Association of Regulatory Utility Commissioners (NARUC) National Rural Electric Cooperative Association (NRECA) Prepared by: Kenneth Rose and Karl Meeusen Preface This manual was prepared by Kenneth Rose, a consultant and Senior Fellow at the Institute of Public Utilities at Michigan State University, and Karl Meeusen,

  3. Benchmarking for electric utilities, tree trimming benchmarking, service line installation to single family residence, and distribution revenue meter testing and repair

    SciTech Connect

    Harder, J.

    1994-12-31

    An American Public Power Association (APPA) task force study on benchmarking for electric utilities is presented. Benchmark studies were made of three activities: (1) Tree trimming; (2) Service line installation to single family residence; (3) Distribution revenue meter testing and repair criteria. The results of the study areas are summarized for 15 utilities. The methodologies used for data collection and analysis are discussed. 28 figs., 9 tabs.

  4. In the Matter of National Broadband Plan Request for Information:

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Communications Requirements | Department of Energy In the Matter of National Broadband Plan Request for Information: Communications Requirements In the Matter of National Broadband Plan Request for Information: Communications Requirements The American Public Power Association ("APPA") appreciates this opportunity to respond to the Department of Energy ("the Department" or "DOE") regarding its Request for Information ("RFI") on Implementing the National

  5. NBP RFI: Communications Requirements - Reply Comments of Utilities Telecom

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Council | Department of Energy Requirements - Reply Comments of Utilities Telecom Council NBP RFI: Communications Requirements - Reply Comments of Utilities Telecom Council The Utilities Telecom Council hereby files its reply comments in response to the Department of Energy (DOE) request for information on the communications needs of electric utilities and other such critical infrastructure industries (CII). The comments on the record- including those by APPA, EEI and NRECA, as well as API -

  6. SOUTHEASTERN FEDERAL POWER ALLIANCE - October 9, 2013 | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energy October 9, 2013 SOUTHEASTERN FEDERAL POWER ALLIANCE - October 9, 2013 Southeastern Federal Power Alliance meeting was held on October 9, 2013 at the Municipal Electric Authority of Georgia (MEAG) located at 1470 Riveredge Parkway NW, Atlanta, Georgia. Documents Available for Download Southeastern Federal Power Alliance Meeting Agenda (18.16 KB) Bonham - Introduction to MEAG Power (39.01 KB) Coffman - APPA and Federal Hydro (36.18 KB) Coffman Handout - WRDA Letter to Boxer and Vitter -

  7. An optimized posterior axillary boost technique in radiation therapy to supraclavicular and axillary lymph nodes: A comparative study

    SciTech Connect

    Hernandez, Victor; Arenas, Meritxell; Müller, Katrin; Gomez, David; Bonet, Marta

    2013-01-01

    To assess the advantages of an optimized posterior axillary (AX) boost technique for the irradiation of supraclavicular (SC) and AX lymph nodes. Five techniques for the treatment of SC and levels I, II, and III AX lymph nodes were evaluated for 10 patients selected at random: a direct anterior field (AP); an anterior to posterior parallel pair (AP-PA); an anterior field with a posterior axillary boost (PAB); an anterior field with an anterior axillary boost (AAB); and an optimized PAB technique (OptPAB). The target coverage, hot spots, irradiated volume, and dose to organs at risk were evaluated and a statistical analysis comparison was performed. The AP technique delivered insufficient dose to the deeper AX nodes. The AP-PA technique produced larger irradiated volumes and higher mean lung doses than the other techniques. The PAB and AAB techniques originated excessive hot spots in most of the cases. The OptPAB technique produced moderate hot spots while maintaining a similar planning target volume (PTV) coverage, irradiated volume, and dose to organs at risk. This optimized technique combines the advantages of the PAB and AP-PA techniques, with moderate hot spots, sufficient target coverage, and adequate sparing of normal tissues. The presented technique is simple, fast, and easy to implement in routine clinical practice and is superior to the techniques historically used for the treatment of SC and AX lymph nodes.

  8. BPA-2010-01236-FOIA Correspondence

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    of all emails created by BPA employee Nick Peck relating to the subject of the Teanaway Solar Reserve from December 1, 2009, until the present. In addition, please include any...

  9. SSRLUO 2002 Executive Committee Members | Stanford Synchrotron...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Pingitore University of Texas at El Paso Environmental & Geosciences El Paso, TX 79968-0555 Phone: 915-747-5754 Fax: 915-747-5073 E-mail: nick@geo.utep.edu MACROMOLECULAR...

  10. Recent content in 2014 Geothermal Case Study Challenge | OpenEI...

    OpenEI (Open Energy Information) [EERE & EIA]

    07:41 Question For various reasons, you may w... NickL 6 May 2014 - 07:47 Answer Travis Brown and Kamran Baksh, Final Submission CSM 14 May 2014 - 21:59 Document Groups Menu You...

  11. Ceph: An Open Source Object Store Evan Harvey Gustavo Rayos

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Ceph: An Open Source Object Store Evan Harvey Gustavo Rayos Nick Schuchhardt Mentors: David Bonnie, Chris Hoffman, Dominic Manno LA---UR---15---25907 What is an Object Store? *...

  12. Reviving Algae from the (Almost) Dead - News Feature | NREL

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Reviving Algae from the (Almost) Dead October 31, 2014 Photo of a man in a lab coat standing next to green algae bubbling in containers. NREL Research Technician Nick Sweeney...

  13. "Title","Creator/Author","Publication Date","OSTI Identifier...

    Office of Scientific and Technical Information (OSTI)

    Deep Bed Adsorption Testing using Silver-Functionalized Aerogel","Nick Soelberg; Tony Watson","2012-06-01T04:00:00Z",1062194,"10.21721062194","INLEXT-12-26522","DE-AC07-05ID14517...

  14. Harold Cofer and the COLEX process, part 4 ? Changes to support...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Nick about holding the speed record going from inside Alpha 4 or Alpha 5 to the cooling tower areas. He always wore high top galoshes, especially in Alpha 5 since there was...

  15. Microsoft Word - Climate-Infrastructure-Workshop_agenda_R4.docx

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Wolfram T-4: Misha Chertkov T-5: David Moulton, Aric Hagberg T-6: Nick Hengartner ESC: David Morris ADCLES: Nan Sauer ADTIR: NJ Nicholas ADTSC: John Sarrao, Paul Dotson...

  16. New page curation tool | OpenEI Community

    OpenEI (Open Energy Information) [EERE & EIA]

    links may help you to Posted: 21 Jun 2013 - 14:37 by: NickL Dbrodt Another idea Posted: 22 May 2013 - 08:23 by: Dbrodt Rmckeel Show preview has been removed from utility rate...

  17. Recent content in Water Power Forum | OpenEI Community

    OpenEI (Open Energy Information) [EERE & EIA]

    - 11:43 Question 2013 projects and funding Vanessa.gregory 13 Dec 2013 - 09:12 Question Hi Vanessa-I connected wit... NickL 13 Dec 2013 - 14:38 Answer Worldwide 'Power exchanges'...

  18. Recent content in Geospatial | OpenEI Community

    OpenEI (Open Energy Information) [EERE & EIA]

    - 21:45 Discussion Question about Map of Wind Farms Wzeng 13 Jul 2012 - 13:59 Question Hi, there is a button labeled ... NickL 13 Jul 2012 - 14:21 Answer How can I open .ASC...

  19. National Laboratory Frontiers in Science

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    1801 Mountain Road, N.W., Albuquerque * November 10, Nick L. Salazar Center for the Arts, Northern New Mexico College, 921 Paseo de Oate, Espaola * November 16, James A....

  20. U.S. DEPARTMENT OF ENERGY BIOENERGY TECHNOLOGIES OFFICE

    Energy.gov [DOE] (indexed site)

    ... Biochemical Conversion Feedstock Supply Interface NREL Nick Nagle 1:55 p.m.-2:25 p.m. Determining the Impact of Municipal Solid Waste as a Feedstock Blending Agent on Pretreatment ...

  1. Green Button Applications | OpenEI Community

    OpenEI (Open Energy Information) [EERE & EIA]

    Type Term Title Author Replies Last Post sort icon Blog entry contest DOE Leading by Example with Green Button, American Energy Data Challenge contest 4 NickL 5 May 2015 - 15:37...

  2. Green Button Applications | OpenEI Community

    OpenEI (Open Energy Information) [EERE & EIA]

    Last Post sort icon Blog entry Green Button DOE Leading by Example with Green Button, American Energy Data Challenge contest 4 NickL 5 May 2015 - 15:37 Blog entry Green Button The...

  3. Data Challenge | OpenEI Community

    OpenEI (Open Energy Information) [EERE & EIA]

    NickL(137) Contributor 5 May, 2015 - 15:37 DOE Leading by Example with Green Button, American Energy Data Challenge contest 4 contest Data Challenge Green Button DOE will launch...

  4. contest | OpenEI Community

    OpenEI (Open Energy Information) [EERE & EIA]

    NickL(137) Contributor 5 May, 2015 - 15:37 DOE Leading by Example with Green Button, American Energy Data Challenge contest 4 contest Data Challenge Green Button DOE will launch...

  5. Green Button Applications | OpenEI Community

    OpenEI (Open Energy Information) [EERE & EIA]

    Term Title Author Replies Last Post sort icon Blog entry Data Challenge DOE Leading by Example with Green Button, American Energy Data Challenge contest 4 NickL 5 May 2015 - 15:37...

  6. This list does not imply DOE endorsement of the individuals or...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ... 503-579-8984 OR Simon, Tony simont@energy.wsu.edu 360-956-2141 OR Skupien, Nick NSS@Brabazon.com 920-883-7071 WI Smith, Ben benjamin.smith@cp.com 803-817-7128 SC ...

  7. Green Button: Enabling Energy Innovation | Department of Energy

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Button: Enabling Energy Innovation Green Button: Enabling Energy Innovation May 9, 2013 - 2:35pm Addthis Monisha Shah White House Council on Environmental Quality Nick Sinai U.S. ...

  8. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    ... Filter by Author Chen, Zhucheng (3) Henry, Lisa (2) Pak, Chi W. (2) Bogdan, Sven (1) ... Chi W. ; Liao, Yuxing ; Shi, Shuoyong ; Henry, Lisa ; Grishin, Nick V. ; Bogdan, Sven ; ...

  9. NERSC_Workload_Analysis_v3.pptx

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Brian Austin, Tina Butler, Richard Gerber, Cary Whitney, Nick Wright, Woo-Sun Yang, Zhengji Zhao NERSC Workload Analysis on Hopper --- 1 --- February 2 2, 2 013 Understanding the...

  10. OpenEI Community - bug

    OpenEI (Open Energy Information) [EERE & EIA]

    Ghost" entries http:en.openei.orgcommunitydiscussionghost-entries

    There is an issue that Illinois State University has come across. From Nick B:

  11. Student Spotlight

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    czapla Student Spotlight Nick Czapla Nick Czapla Project Name: Image Analysis Classification algorithm to automatically classify NIF optics damage sites Project Description: Develop a classification system of potential damage sites on the NIF Final Optics based on the sites' morphology (i.e., shape, color, size, roughness of edges, etc.) and automate the classification process using a wavelet transformation algorithm, called the Image Analysis Classification (IAC), written by Wim deVries. The

  12. University of Alaska Fairbanks 2014 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Alaska Fairbanks 2014 University of Alaska Fairbanks 2014 From left to right: Shannan Hoyos, Ed Greene, Matthew Staley, Patrick Wade, Nick Janssen, Chic O'Dell, Pryce Brown, Bruce Lee, Wyatt Rehder, Dominic Dionne. Photo from the University of Alaska, Fairbanks. From left to right: Shannan Hoyos, Ed Greene, Matthew Staley, Patrick Wade, Nick Janssen, Chic O'Dell, Pryce Brown, Bruce Lee, Wyatt Rehder, Dominic Dionne. Photo from the University of Alaska, Fairbanks. Project Description For the

  13. Hydrogen Equipment Certification Guide

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Equipment Certification Guide U.S. Department of Energy Fuel Cell Technologies Office December 10 th , 2015 Presenter: Nick Barilo Pacific Northwest National Laboratory (PNNL) Hydrogen Safety Program Manager DOE Host: Will James - DOE Fuel Cell Technologies Office 2 | Fuel Cell Technologies Office eere.energy.gov Question and Answer * Please type your questions into the question box 2 / / Hydrogen Equipment Certification Guide: Introduction and Kickoff for the Stakeholder Review Nick Barilo PNNL

  14. Final DOE Areas Feasibility Study, Appendices A - F

    Office of Legacy Management (LM)

    DOE Areas Feasibility Study Appendices LEHR CERCLA Completion Rev. 0 03/07/08 J:\DOE_STOLLER\4110\143\FEASIBILITY_STUDY\20080307_FS_TEXT_REV0.DOC WEISS ASSOCIATES Project Number: 130-4110-143 APPENDIX A COST ESTIMATES Final DOE Areas Feasibility Study Appendix A LEHR CERCLA Completion Rev. 0 03/07/08 Tables J:\DOE_Stoller\4110\143\Feasibility_Study\Rev0\Appendices\20080307_FS_APPA_tbls.doc Weiss Associates Project Number: 130-4110-143 Table A-1. Feasibility Study Cost Estimate Summaries Area/

  15. COMPLEAT (Community-Oriented Model for Planning Least-Cost Energy Alternatives and Technologies): A planning tool for publicly owned electric utilities. [Community-Oriented Model for Planning Least-Cost Energy Alternatives and Technologies (Compleat)

    SciTech Connect

    Not Available

    1990-09-01

    COMPLEAT takes its name, as an acronym, from Community-Oriented Model for Planning Least-Cost Energy Alternatives and Technologies. It is an electric utility planning model designed for use principally by publicly owned electric utilities and agencies serving such utilities. As a model, COMPLEAT is significantly more full-featured and complex than called out in APPA's original plan and proposal to DOE. The additional complexity grew out of a series of discussions early in the development schedule, in which it became clear to APPA staff and advisors that the simplicity characterizing the original plan, while highly desirable in terms of utility applications, was not achievable if practical utility problems were to be addressed. The project teams settled on Energy 20/20, an existing model developed by Dr. George Backus of Policy Assessment Associates, as the best candidate for the kinds of modifications and extensions that would be required. The remainder of the project effort was devoted to designing specific input data files, output files, and user screens and to writing and testing the compute programs that would properly implement the desired features around Energy 20/20 as a core program. This report presents in outline form, the features and user interface of COMPLEAT.

  16. Radiation dose delivery verification in the treatment of carcinoma-cervix

    SciTech Connect

    Shrotriya, D. Srivastava, R. N. L.; Kumar, S.

    2015-06-24

    The accurate dose delivery to the clinical target volume in radiotherapy can be affected by various pelvic tissues heterogeneities. An in-house heterogeneous woman pelvic phantom was designed and used to verify the consistency and computational capability of treatment planning system of radiation dose delivery in the treatment of cancer cervix. Oncentra 3D-TPS with collapsed cone convolution (CCC) dose calculation algorithm was used to generate AP/PA and box field technique plan. the radiation dose was delivered by Primus Linac (Siemens make) employing high energy 15 MV photon beam by isocenter technique. A PTW make, 0.125cc ionization chamber was used for direct measurements at various reference points in cervix, bladder and rectum. The study revealed that maximum variation between computed and measured dose at cervix reference point was 1% in both the techniques and 3% and 4% variation in AP/PA field and 5% and 4.5% in box technique at bladder and rectum points respectively.

  17. Progress & Frontiers in PV Performance, NREL (National Renewable Energy Laboratory)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    & Frontiers in PV Performance Chris Deline, Nick DiOrio, Dirk Jordan, NREL Fatima Toor, University of Iowa September 12, 2016 Solar Power International 2016 Las Vegas, Nevada NREL/PR-5J00-67174 2 Outline 8:00 Workshop introduction Chris Deline (NREL) 8:15 SAM introduction and battery modeling Nick DiOrio (NREL) 9:15 Bifacial modules and modeling Fatima Toor (University of Iowa) 10:00 Break 10:15 Shade modeling and MLPE Chris Deline (NREL) 11:00 Degradation rates Dirk Jordan (NREL) 11:30

  18. Student Spotlight

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    zobrist Student Spotlight Nick Zobrist Nick Zobrist Junior (graduating spring 2015) Physics and Applied Mathematics, U.C. Berkeley, Area of NIF: Optics Inspection Tell us about your work at NIF. I'm here to contribute to the optics inspection algorithms that evaluate the condition of NIF's optics. One of the ways I've done this is by modeling reflection locations which is a new capability that they've needed, but I've helped my mentor, Laura Kegelmeyer, with parts of other projects as well. You

  19. Crossroads Specifications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Specifications Crossroads Specifications A critical element for improved predictive capability Contacts APEX Representatives Jim Lujan Los Alamos National Laboratory Jim Laros Sandia National Laboratories Jay Srinivasan Berkeley Lab Nick Wright Berkeley Lab A draft of the APEX 2020 technical specification is currently available at APEX website. Please contact the APEX representatives for details

  20. Recent content in Green Button Applications | OpenEI Community

    OpenEI (Open Energy Information) [EERE & EIA]

    Jun 2012 - 15:45 Blog entry OpenEI green button SDK Vgarud 5 Feb 2013 - 11:17 Question Hi Vivek-

    I reached... NickL 8 Feb 2013 - 14:03 Answer Probably the best reference...

  1. The impact of breathing motion versus heterogeneity effects in lung cancer treatment planning

    SciTech Connect

    Rosu, Mihaela; Chetty, Indrin J.; Tatro, Daniel S.; Haken, Randall K. ten

    2007-04-15

    The purpose of this study is to investigate the effects of tissue heterogeneity and breathing-induced motion/deformation on conformal treatment planning for pulmonary tumors and to compare the magnitude and the clinical importance of changes induced by these effects. Treatment planning scans were acquired at normal exhale/inhale breathing states for fifteen patients. The internal target volume (ITV) was defined as the union of exhale and inhale gross tumor volumes uniformly expanded by 5 mm. Anterior/posterior opposed beams (AP/PA) and three-dimensional (3D)-conformal plans were designed using the unit-density exhale (''static'') dataset. These plans were further used to calculate (a) density-corrected (''heterogeneous'') static dose and (b) heterogeneous cumulative dose, including breathing deformations. The DPM Monte Carlo code was used for dose computations. For larger than coin-sized tumors, relative to unit-density plans, tumor and lung doses increased in the heterogeneity-corrected plans. In comparing cumulative and static plans, larger normal tissue complication probability changes were observed for tumors with larger motion amplitudes and uncompensated breathing-induced hot/cold spots in lung. Accounting for tissue heterogeneity resulted in average increases of 9% and 7% in mean lung dose (MLD) for the 6 MV and 15 MV photon beams, respectively. Breathing-induced effects resulted in approximately 1% and 2% average decreases in MLD from the static value, for the 6 and 15 MV photon beams, respectively. The magnitude of these effects was not found to correlate with the treatment plan technique, i.e., AP/PA versus 3D-CRT. Given a properly designed ITV, tissue heterogeneity effects are likely to have a larger clinical significance on tumor and normal lung treatment evaluation metrics than four-dimensional respiratory-induced changes.

  2. SU-E-T-404: Simple Field-In-Field Technique for Total Body Irradiation in Large Patients

    SciTech Connect

    Chi, P; Pinnix, C; Dabaja, B; Wang, C; Aristophanous, M; Tung, S

    2014-06-01

    Purpose: A simple Field-in-Field technique for Total Body Irradiation (TBI) was developed for traditional AP/PA TBI treatments to improve dosimetric uniformity in patients with large separation. Methods: TBI at our institution currently utilizes an AP/PA technique at an extended source-to-surface distance (SSD) of 380cm with patients in left decubitus position during the AP beam and in right decubitus during the PA beam. Patients who have differences in thickness (separation) between the abdomen and head greater than 10cm undergo CT simulation in both left and right decubitus treatment positions. One plan for each CT is generated to evaluate dose to patient midline with both AP and PA fields, but only corresponding AP fields will be exported for treatment for patient left decubitus position and PA fields for patient right decubitus position. Subfields are added by collimating with the x-ray jaws according to separation changes at 5–7% steps to minimize hot regions to less than 10%. Finally, the monitor units (MUs) for the plans are verified with hand calculation and water phantom measurements. Results: Dose uniformity (+/−10%) is achieved with field-in-field using only asymmetric jaws. It is dosimetrically robust with respect to minor setup/patient variations inevitable due to patient conditions. MUs calculated with Pinnacle were verified in 3 clinical cases and only a 2% difference was found compared to homogeneous calculation. In-vivo dosimeters were also used to verify doses received by each patient with and confirmed dose variations less than 10%. Conclusion: We encountered several cases with separation differences that raised uniformity concerns — based on a 1% dose difference per cm separation difference assumption. This could Resultin an unintended hot spot, often in the head/neck, up to 25%. This method allows dose modulation without adding treatment complexity nor introducing radiobiological variations, providing a reasonable solution for this unique

  3. Designing Targets for Elective Nodal Irradiation in Lung Cancer Radiotherapy: A Planning Study

    SciTech Connect

    Kepka, Lucyna; Tatro, Daniel; Moran, Jean M.; Quint, Leslie E.; Hayman, James A.; Ten Haken, Randall K.; Kong Fengming

    2009-04-01

    Purpose: To assess doses received by mediastinal and hilar lymph node stations (LNS) delineated according to published recommendations when 'standard' two-dimensional (2D) elective fields are applied and to assess doses to critical structures when fields are designed using 2D and three-dimensional (3D) treatment planning for elective irradiation. Methods and Materials: LNS were delineated on axial CT scans according to existing recommendations. For each case and tumor location, 2D anteroposterior-posteroanterior (AP-PA) elective fields were applied using the AP-PA CT topograms. From the 2D portal fields, 3D dose distributions were then calculated to particular LNS. Next, 3D plans were prepared for elective nodal irradiation for tumors of different lobes. Doses for critical structures were compared for 2D and 3D plans. Results: LNS 1/2R, 1/2L, 3A, 3P, 5, 6, and 8 were not adequately covered in a substantial part of plans by standard 2D portals when guidelines for delineation were strictly followed. The magnitude of the lack of coverage increased with margin application. There was a trend for a higher yet probably still safe dose delivered to lung for 3D plans compared with 2D plans with a prescription dose of 45 Gy. Conclusions: 2D fields did not entirely cover LNS delineated according to the recommendations for 3D techniques. A strict adherence to these guidelines may lead to larger portals than traditionally constructed using 2D methods. Some modifications for clinical implementation are discussed.

  4. NREL: Dynamic Maps, GIS Data, and Analysis Tools - Geospatial Team

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Geospatial Data Science Team The following are members of NREL's Geospatial Data Science Team: Jon Duckworth Michael Gleason Nick Grue Pamela Gray-Hann Donna Heimiller Dylan Hettinger Ted Kwasnik Anthony Lopez Galen Maclaurin Meghan Mooney Ricardo Oliveira Billy J. Roberts If you have questions about our programs or would like to contact our staff, please contact us through the Geospatial Data Science Team email. Printable Version NREL GIS Home About NREL GIS Renewable Energy Technical Potential

  5. Innovative imaging systems on the Wendelstein 7-X bring steady-state fusion

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    energy closer to reality Innovative imaging systems on the Wendelstein Innovative imaging systems on the Wendelstein 7-X bring steady-state fusion energy closer to reality Innovative new imaging systems designed at Los Alamos are helping physicists peer into the roiling world of superhot plasmas. January 27, 2016 Glen Wurden in the stellarator's vacuum vessel during camera installation in 2014. Glen Wurden in the stellarator's vacuum vessel during camera installation in 2014. Contact Nick

  6. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Nick Soelberg" Name Name ORCID Product Type: All Book/Monograph Conference/Event Journal Article Miscellaneous Patent Program Document Software Manual Technical Report Thesis/Dissertation Subject: Identifier Numbers: Site: All Alaska Power Administration, Juneau, Alaska (United States) Albany Research Center (ARC), Albany, OR (United States) Albuquerque Complex - NNSA Albuquerque Operations Office, Albuquerque, NM (United States) Amarillo National Resource Center for Plutonium, Amarillo, TX

  7. Frequently Asked Questions

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Advice from LADSS Alumni Nick Martinez, 2014 1. Choose your project wisely. Thoroughly review each project scope and referenced material when making your decision. 2. Once you are assigned a project, familiarize yourself with the required theory and background literature before the start of the summer school. 3. Immediately familiarize yourself with the experimental hardware setup. This will expedite your project's progress, especially if you are unfamiliar with the specific hardware/software.

  8. About Crossroads

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    About About Crossroads A critical element for improved predictive capability Contacts APEX Representatives Jim Lujan Los Alamos National Laboratory Jim Laros Sandia National Laboratories Jay Srinivasan Berkeley Lab Nick Wright Berkeley Lab As the Nation's nuclear stockpile moves further from the nuclear test base due to aging, remanufactured components, and Life Extension Programs (LEP), the need for predictive weapon calculations is becoming increasingly urgent. Crossroads, the third Advanced

  9. Biochemical Feedstock Interface Presentation for BETO 2015 Project Peer Review

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Feedstock Interface BETO 2015 Project Peer Review March 23, 2015 Washington D.C. Nick Nagle Allison Ray Garold Gresham National Renewable Energy Laboratory Idaho National Laboratory This presentation does not contain any proprietary, confidential, or otherwise restricted information WBS 2.2.1.100, 2.2.1.101, & 2.2.1.102 2 | Bioenergy Technologies Office Goal Statement Goal: * Understand the impact of feedstock logistics & preprocessing on blend conversion performance Relevance to BETO

  10. Business Opportunity Session Materials | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Business Opportunity Session Materials Business Opportunity Session Materials Presentations from our Washington DC Business Opportunity Session, held March 3, 2011 How to do Business with DOE Nickolas (Nick) Demer Senior Procurement Analyst OSDBU NNSA Opportunities Gary Lyttek Small Business Program Manager, NNSA Sandia National Laboratories Opportunities Don Devoti, Small Business Program Manager, Sandia National Laboratories Office of Science SBIR/STTR, Chris O'Gwin, Program Analyst, SBIR/STTR

  11. SREL Reprint #3214

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    4 Dispersal via stream corridors structures populations of the endangered St. Francis' satyr butterfly (Neonympha mitchellii francisci) Laura V. Milko1, Nick M. Haddad1, and Stacey L. Lance2 1Department of Biology, North Carolina State University, Raleigh, NC 27695, USA 2Savannah River Ecology Laboratory, University of Georgia, Aiken, SC 29802, USA Abstract: Habitat fragmentation may reduce gene flow and population viability of rare species. We tested whether riparian corridors enhanced gene

  12. Slide 1

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Business Opportunity Session Presenter: Nick Demer Senior Procurement Analyst September 24, 2009 Office of Small & Disadvantaged Business Utilization DOE Business Model Site and Facility Management Contractors (FMCs) Management and Operating (M&O) Contracts (FAR 17.6) DOE owns land and facilities, contractor employs research, development, and production personnel; and manages facility. Limited Liability Corporations (LLC) - Only responsibility is to manage and operate specific facility

  13. Cosmic Reionization On Computers | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Simulation of cosmic reionization Simulation of cosmic reionization. Dark red shows opaque neutral gas, transparent blue is ionized gas, and yellow dots are galaxies. Nick Gnedin, Fermilab Cosmic Reionization On Computers PI Name: Nickolay Gnedin PI Email: gnedin@fnal.gov Institution: Fermilab Allocation Program: INCITE Allocation Hours at ALCF: 65 Million Year: 2016 Research Domain: Physics Cosmic reionization, the most recent phase transition in the history of the universe, is the process by

  14. tajikistan | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    tajikistan Dedication of Radioactive Source Storage Facilities in Tajikistan (Dushanbe, Tajikistan) - On May 11, the United States' Embassy of Tajikistan, the Department of Energy/National Nuclear Security Administration (DOE/NNSA), the United Kingdom's Department of Energy and Climate Change (DECC), and the Government of Tajikistan dedicated two... NNSA Provides Tajikistan Specialized Vehicles to Transport Radiological Materials NNSA Program Manager Nick Cavellero, right, and NRSA Director of

  15. Microsoft PowerPoint - Salishan_17

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Work out of New, High-End Systems Michael Levine/Ralph Roskies Scientific Directors, PSC (Nick Nystrom, AD Apps Ray Scott, AD Operations) The Salishan Conference on High-Speed Computing April 20, 2005 Pittsburgh Supercomputing Center 2 Salishan 2005: : 6/2/2006 5:07:23 PM Introduction & Background * Thanks to Salishan Conference organizers for invitation. * Start with a very brief intro to PSC * Explain basis of experience for this talk * Been in business since 1985 * Predominantly, but not

  16. System Configuration

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    System Configuration (D1SA) Co-Chairs: Clay England (OLCF) & Jason Hick (NERSC) 1 Contributors * Andrew Cherry (ALCF) * Cory Lueninghoener (LANL) * Curt Canada (LANL) * Robin Goldstone (LLNL) * Jim Silva (LLNL) * Jason Hick (NERSC) * Nick Wright (NERSC) * Clay England (OLCF) * Chris Beggio (SNL) * Bob Ballance (SNL) * Glenn Lockwood (SDSC) * Eli Dart (ESnet) 2 What is a data analytics system and what are the hardware characteristics? * A new area for HPC which needs a flexible system *

  17. 2013 DOE Bioenergy Technologies Office (BETO) Project Peer Review

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Biochemical Feedstock Supply Interface Garold Gresham, INL Nick Nagle, NREL May 20, 2013 2 | Bioenergy Technologies Office eere.energy.gov Goals: Support Biochemical Conversion Pathway: "reducing the cost of converting lignocellulosic biomass to sugars and other fuels intermediates." 1 - Facilitate establishment of pathway(s) toward optimization and cost-reduction; 2 - Develop tools & models to evaluate feedstock costs & quality for BC conversion process (biological, chemical,

  18. The Water-Energy Nexus: Challenges and Opportunities | Department of Energy

    Energy.gov [DOE] (indexed site)

    Monisha Shah White House Council on Environmental Quality Nick Sinai U.S. Deputy Chief Technology Officer, White House Office of Science and Technology Policy What does this mean for me? Households and businesses can more easily use web and smartphone apps to pick the best rate plan for them. Consumers can take advantage of customized energy efficiency tips for their homes and businesses. Easy-to-use tools are available to help consumers size and finance rooftop solar panels. Virtual energy

  19. Renewable Fuels from Algae Boosted by NREL Refinery Process - News Releases

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    | NREL Renewable Fuels from Algae Boosted by NREL Refinery Process February 9, 2016 A new biorefinery process developed by scientists at the Energy Department's National Renewable Energy Laboratory (NREL) has proven to be significantly more effective at producing ethanol from algae than previous research. The process, dubbed Combined Algal Processing (CAP), is detailed in a new paper by NREL's Tao Dong, Eric Knoshaug, Ryan Davis, Lieve Laurens, Stefanie Van Wychen, Philip Pienkos, and Nick

  20. Attendees

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Attendees Attendees Registered Attendees Sean Ahern Oak Ridge National Laboratory William Allcock Argonne National Laboratory Sasha Ames Lawrence Livermore National Laboratory Katie Antypas NERSC Stephen Bailey LBNL Robert Ballance Sandia National Laboratories Nick Balthaserr NERSC Ashley Barker Oak Ridge Leadership Computing Facility Blaise Barney LLNL Christopher Beggio Sandia National Laboratories Wes Bethel LBNL Laura Biven DOE Kristofer Bouchard LBNL Jeff Broughton NERSC Suren Byna LBNL

  1. Biosecurity and Health

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Biosecurity and Health Biosecurity and Health Los Alamos scientists are developing science and technology designed to battle pathogens responsible for causing disease epidemics, and extreme cases, pandemics. Contact Us Kirsten McCabe Emerging Threats Program Manager Email Andrew Bradbury Bioscience Group Leader Email Nick Hengartner Theoretical Biology and Biophysics Group Leader Email Rebecca McDonald Communication Specialist Email Projects in this subject area are concerned with countering

  2. AEO2014 Coal Working Group Meeting I Summary

    Energy Information Administration (EIA) (indexed site)

    July 22, 2013 MEMORANDUM TO: John Conti Assistant Administrator for Energy Analysis Alan Beamon Director, Office of Electricity, Coal, Nuclear, and Renewables Analysis FROM: Coal and Uranium Analysis Team SUBJECT: AEO2014 Coal Working Group Meeting I Summary Attendees (41) Name Affiliation Greg Adams (Moderator) US DOE: EIA Vlad Dorjets Bob Eynon Karen Freedman Tyler Hodge Paul Holtberg Elias Johnson Ayaka Jones Diane Kearney Mike Leff Mike Mellish Carrie Milton Nick Paduano Margaret Cook US

  3. Present and Future Computing Requirements

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Computational Cosmology DES LSST Presenter: Salman Habib Argonne National Laboratory Jim Ahrens (LANL) Scott Dodelson (FNAL) Katrin Heitmann (ANL) Peter Nugent (LBNL) Anze Slosar (BNL) Risa Wechsler (SLAC) 1 Cosmic Frontier Computing Collaboration Computational Cosmology SciDAC-3 Project Ann Almgren (LBNL) Nick Gnedin (FNAL) Dave Higdon (LANL) Rob Ross (ANL) Martin White (UC Berkeley/ LBNL) Large Scale Production Computing and Storage Requirements for High Energy Physics Research A DOE Technical

  4. Renewable Fuels from Algae Boosted by NREL Refinery Process | Bioenergy |

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    NREL Renewable Fuels from Algae Boosted by NREL Refinery Process February 9, 2016 A new biorefinery process developed by scientists at the Energy Department's National Renewable Energy Laboratory (NREL) has proven to be significantly more effective at producing ethanol from algae than previous research. The process, dubbed Combined Algal Processing (CAP), is detailed in a new paper by NREL's Tao Dong, Eric Knoshaug, Ryan Davis, Lieve Laurens, Stefanie Van Wychen, Philip Pienkos, and Nick

  5. Lab scientists track Santa's magical journey

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Santa's magical journey Lab scientists track Santa's magical journey Los Alamos trackers will use state-of-the-art technology to mark the course taken by Old St. Nick and his reindeer. December 20, 2010 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials. Los Alamos National Laboratory

  6. Los Alamos computational scientist wins 2016 Carcinogenesis Young

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Investigator Award 2016 Carcinogenesis Young Investigator Award Los Alamos computational scientist wins 2016 Carcinogenesis Young Investigator Award Ludmil Alexandrov is the winner of the 2016 Carcinogenesis Young Investigator Award. July 11, 2016 Ludmil Alexandrov Ludmil Alexandrov Contact Los Alamos National Laboratory Nick Njegomir Communications Office (505) 665-9394 Email "Ludmil's research uses large-scale computational screening and analysis to understand the mutational processes

  7. Los Alamos names Laboratory Fellows for 2015

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Los Alamos names Laboratory Fellows for 2015 Los Alamos names Laboratory Fellows for 2015 The honorees are Michael Bernardin, Avadh Saxena, Carlos Tome and Piotr Zelenay. January 27, 2016 Piotr Zelenay, Carlos Tome, Michael Bernardin and Avadh Saxena Piotr Zelenay, Carlos Tome, Michael Bernardin and Avadh Saxena Contact Nick Njegomir Communications Office (505) 665-9394 Email "The Laboratory Fellows Organization recognizes researchers for innovative scientific and technical advances in

  8. Los Alamos scientist receives prestigious fellowship

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Los Alamos scientist receives prestigious fellowship Los Alamos scientist receives prestigious fellowship The American Association for the Advancement of Science (AAAS) has awarded the distinction of Fellow to Dave Morris. January 11, 2016 Dave Morris Dave Morris Contact Nick Njegomir Communications Office (505) 665-9394 Email "The AAAS fellowship is a great honor that recognizes Dave's prominence as a chemistry researcher and a scientific leader," said Carol Burns, Deputy Principal

  9. Los Alamos' Terwilliger named American Crystallographic Association

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    president Terwilliger named American Crystallographic Association president Los Alamos' Terwilliger named American Crystallographic Association president The ACA is the home to more than 1,000 scientists around the country who use X-rays, neutrons and electrons to see the shapes of molecules. April 27, 2016 Tom Terwilliger Tom Terwilliger Contact Nick Njegomir Communications Office (505) 665-9394 Email "This is an exciting time for crystallography because there are new ways to look at

  10. Participants

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Participants Participants Large Scale Computing and Storage Requirements for Basic Energy Sciences A DOE Technical Program Review October 8-9, 2013 Front row, from left: Yun Liu, Dave Goodwin, Eliane Lessner, Jack Deslippe, Nick Woodward, Carl Steefel, Ceren Susut, Katie Antypas, Richard Gerber. Back row, from left: Scott French, Jeff Neaton, Sudip Dosanjh, Harvey Wasserman, Jim Davenport, David Skinner, Andy Felmy, Jacqueline Chen, Sotiris Xantheas, Greg Newman, Mark Pederson. Organizers and

  11. Participants

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Participants Participants Large Scale Computing and Storage Requirements for Basic Energy Sciences An ASCR / BES / NERSC Workshop February 9-10, 2010 Name Organization Area James Davenport DOE/BES & Brookhaven National Lab Materials Sciences and Engineering Division; Theoretical Condensed Matter Physics Mark Pederson DOE/BES Chemical Sciences, Geosciences, and Biosciences Division; Computational and Theoretical Chemistry Nick Woodward DOE/BES Chemical Sciences, Geosciences, and Biosciences

  12. 2012-2013 Research Communications Program | MIT-Harvard Center for

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Excitonics 2-2013 Research Communications Program Dylan Gleb and Geoffrey - outreach project Participants: Gleb Akselrod Dylan Arias Jordan Chesin Daniel Congreve Dorthe Eisele Joey Goodknight Vitor Manfrinato Phil Reusswig Geoffrey Supran Nick Thompson Stephanie Valleau Shane Yost Nano-day Photos Project Photos Video: How Solar Panels Work by Shane Yost and Jordan Chesin Video: The Exciting World of Excitons by Stephanie Valleau and Dan Congreve Video: Electron-Beam Lithography Toward the

  13. National Evaluation of the State Energy Program: An Evaluation of Select Activities Conducted Under the State Energy Program

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    STATE ENERGY PROGRAM: AN EVALUATION OF SELECT ACTIVITIES CONDUCTED UNDER THE STATE ENERGY PROGRAM EXECUTIVE SUMMARY Prepared for the US Department of Energy under the Supervision of Oak Ridge National Laboratory Date: April 2015 DNV GL - www.dnvgl.com DNV GL - www.dnvgl.com ACKNOWLEDGEMENTS We would like to acknowledge the important contributions of the following people: Nick Hall of TecMarket Works was integrally involved with the SEP National Evaluation from its inception, proposing a study

  14. At Plasma Camp, teachers experience research front and center | Princeton

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Plasma Physics Lab At Plasma Camp, teachers experience research front and center By Constance Kaita August 12, 2013 Tweet Widget Google Plus One Share on Facebook Wendy Dlakic, a physics and earth science teacher from Livingston, Mont., examines a plasma with Nick Guilbert, a master teacher and collaborator from The Peddie School, at this year's Plasma Camp for physics teachers at PPPL from July 15 to 19. (Photo by Photo by Elle Starkman/ PPPL Office of Communications) Wendy Dlakic, a

  15. How Do High Levels of Wind and Solar Impact the Grid? The Western Wind and Solar Integration Study

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    How Do High Levels of Wind and Solar Impact the Grid? The Western Wind and Solar Integration Study Debra Lew National Renewable Energy Laboratory Dick Piwko, Nick Miller, Gary Jordan, Kara Clark, and Lavelle Freeman GE Energy Technical Report NREL/TP-5500-50057 December 2010 NREL is a national laboratory of the U.S. Department of Energy, Office of Energy Efficiency & Renewable Energy, operated by the Alliance for Sustainable Energy, LLC. National Renewable Energy Laboratory 1617 Cole

  16. Henderson County North Middle School wins 2015 DOE West Kentucky Regional

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Science Bowl | Department of Energy Henderson County North Middle School wins 2015 DOE West Kentucky Regional Science Bowl Henderson County North Middle School wins 2015 DOE West Kentucky Regional Science Bowl February 6, 2015 - 12:08pm Addthis 1st Place Henderson County North Middle School, from left: (Top) Deegan Lawrence, Coach Chris Fifer and D.J. Banks. (Bottom) Luke Payne, Alex Chandler and Nick Cissell (not pictured). 1st Place Henderson County North Middle School, from left: (Top)

  17. NNSA Provides Tajikistan Specialized Vehicles to Transport Radiological

    National Nuclear Security Administration (NNSA)

    Materials | National Nuclear Security Administration | (NNSA) Provides Tajikistan Specialized Vehicles to Transport Radiological Materials October 07, 2015 NNSA Program Manager Nick Cavellero, right, and NRSA Director of the Department of Information and International Relations Ilkhom Mirsaidov, left, with two specialized vehicles purchased by NNSA for Tajikistan. WASHINGTON - The Department of Energy's National Nuclear Security Administration (DOE/NNSA), the United States Embassy of

  18. Office of Radiological Security | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    Radiological Security NNSA Receives Excellence Award for Radiological Security Enhancements in Hawaii HONOLULU - At an official event this week, the City and County of Honolulu presented the Department of Energy's (DOE) National Nuclear Security Administration (NNSA) with the Homeland Security Excellence Award for DOE/NNSA's Office of Radiological Security's (ORS) efforts... NNSA Provides Tajikistan Specialized Vehicles to Transport Radiological Materials NNSA Program Manager Nick Cavellero,

  19. ors | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    ors NNSA Receives Excellence Award for Radiological Security Enhancements in Hawaii HONOLULU - At an official event this week, the City and County of Honolulu presented the Department of Energy's (DOE) National Nuclear Security Administration (NNSA) with the Homeland Security Excellence Award for DOE/NNSA's Office of Radiological Security's (ORS) efforts... NNSA Provides Tajikistan Specialized Vehicles to Transport Radiological Materials NNSA Program Manager Nick Cavellero, right, and NRSA

  20. Method for introducing unidirectional nested deletions

    DOEpatents

    Dunn, John J.; Quesada, Mark A.; Randesi, Matthew

    1999-07-27

    Disclosed is a method for the introduction of unidirectional deletions in a cloned DNA segment. More specifically, the method comprises providing a recombinant DNA construct comprising a DNA segment of interest inserted in a cloning vector, the cloning vector having an f1 endonuclease recognition sequence adjacent to the insertion site of the DNA segment of interest. The recombinant DNA construct is then contacted with the protein pII encoded by gene II of phage f1 thereby generating a single-stranded nick. The nicked DNA is then contacted with E. coli Exonuclease III thereby expanding the single-stranded nick into a single-stranded gap. The single-stranded gapped DNA is then contacted with a single-strand-specific endonuclease thereby producing a linearized DNA molecule containing a double-stranded deletion corresponding in size to the single-stranded gap. The DNA treated in this manner is then incubated with DNA ligase under conditions appropriate for ligation. Also disclosed is a method for producing single-stranded DNA probes. In this embodiment, single-stranded gapped DNA, produced as described above, is contacted with a DNA polymerase in the presence of labeled nucleotides to fill in the gap. This DNA is then linearized by digestion with a restriction enzyme which cuts outside the DNA segment of interest. The product of this digestion is then denatured to produce a labeled single-stranded nucleic acid probe.

  1. Determining orientation and direction of DNA sequences

    DOEpatents

    Goodwin, Edwin H.; Meyne, Julianne

    2000-01-01

    Determining orientation and direction of DNA sequences. A method by which fluorescence in situ hybridization can be made strand specific is described. Cell cultures are grown in a medium containing a halogenated nucleotide. The analog is partially incorporated in one DNA strand of each chromatid. This substitution takes place in opposite strands of the two sister chromatids. After staining with the fluorescent DNA-binding dye Hoechst 33258, cells are exposed to long-wavelength ultraviolet light which results in numerous strand nicks. These nicks enable the substituted strand to be denatured and solubilized by heat, treatment with high or low pH aqueous solutions, or by immersing the strands in 2.times.SSC (0.3M NaCl+0.03M sodium citrate), to name three procedures. It is unnecessary to enzymatically digest the strands using Exo III or another exonuclease in order to excise and solubilize nucleotides starting at the sites of the nicks. The denaturing/solubilizing process removes most of the substituted strand while leaving the prereplication strand largely intact. Hybridization of a single-stranded probe of a tandem repeat arranged in a head-to-tail orientation will result in hybridization only to the chromatid with the complementary strand present.

  2. Method for producing labeled single-stranded nucleic acid probes

    DOEpatents

    Dunn, John J.; Quesada, Mark A.; Randesi, Matthew

    1999-10-19

    Disclosed is a method for the introduction of unidirectional deletions in a cloned DNA segment. More specifically, the method comprises providing a recombinant DNA construct comprising a DNA segment of interest inserted in a cloning vector, the cloning vector having an f1 endonuclease recognition sequence adjacent to the insertion site of the DNA segment of interest. The recombinant DNA construct is then contacted with the protein pII encoded by gene II of phage f1 thereby generating a single-stranded nick. The nicked DNA is then contacted with E. coli Exonuclease III thereby expanding the single-stranded nick into a single-stranded gap. The single-stranded gapped DNA is then contacted with a single-strand-specific endonuclease thereby producing a linearized DNA molecule containing a double-stranded deletion corresponding in size to the single-stranded gap. The DNA treated in this manner is then incubated with DNA ligase under conditions appropriate for ligation. Also disclosed is a method for producing single-stranded DNA probes. In this embodiment, single-stranded gapped DNA, produced as described above, is contacted with a DNA polymerase in the presence of labeled nucleotides to fill in the gap. This DNA is then linearized by digestion with a restriction enzyme which cuts outside the DNA segment of interest. The product of this digestion is then denatured to produce a labeled single-stranded nucleic acid probe.

  3. Method for introducing unidirectional nested deletions

    DOEpatents

    Dunn, J.J.; Quesada, M.A.; Randesi, M.

    1999-07-27

    Disclosed is a method for the introduction of unidirectional deletions in a cloned DNA segment. More specifically, the method comprises providing a recombinant DNA construct comprising a DNA segment of interest inserted in a cloning vector. The cloning vector has an f1 endonuclease recognition sequence adjacent to the insertion site of the DNA segment of interest. The recombinant DNA construct is then contacted with the protein pII encoded by gene II of phage f1 thereby generating a single-stranded nick. The nicked DNA is then contacted with E. coli Exonuclease III thereby expanding the single-stranded nick into a single-stranded gap. The single-stranded gapped DNA is then contacted with a single-strand-specific endonuclease thereby producing a linearized DNA molecule containing a double-stranded deletion corresponding in size to the single-stranded gap. The DNA treated in this manner is then incubated with DNA ligase under conditions appropriate for ligation. Also disclosed is a method for producing single-stranded DNA probes. In this embodiment, single-stranded gapped DNA, produced as described above, is contacted with a DNA polymerase in the presence of labeled nucleotides to fill in the gap. This DNA is then linearized by digestion with a restriction enzyme which cuts outside the DNA segment of interest. The product of this digestion is then denatured to produce a labeled single-stranded nucleic acid probe. 1 fig.

  4. Establishment of the United States Navy Mine Warfare Center of Excellence in the Corpus Christi Bay Area, Texas

    SciTech Connect

    Kosclski, J.L.; Boyer, R.; Sloger, W.

    1997-08-01

    The proposed establishment of the US Navy Mine Warfare Center of Excellence (MWCE) in the Corpus Christi Bay Area, Texas, involved the collocation of the Navy`s Mine Warfare and Mine Counter Measures assets in proximity to each other at Naval Station (NAVSTA) Ingleside and Naval Air Station (NAS) Corpus Christi, Texas. Collocation of these Navy forces would provide significant advantages in meeting mission and operational requirements. This action would improve the operational training and readiness of the forces. In addition to new construction or modifications at NAVSTA Ingleside, NAS Corpus Christi, and off-base; the establishment of offshore training and operating areas was required. When the project was first proposed in 1993, considerable concern was expressed by environmental interests, shrimpers, and state and federal resource agencies regarding the impact of the proposed training activities within Gulf waters. The Navy and Turner Collie and Braden, Inc., under contract to the Navy, conducted several technical studies and extensive coordination with concerned interests during the environmental impact statement process to identify and document the potential intensity, magnitude, and duration of impact from each proposed training activity.

  5. Oxygen-­dependent regulation of bacterial lipid production

    DOE PAGES [OSTI]

    Lemmer, Kimberly C.; Dohnalkova, Alice C.; Noguera, Daniel R.; Donohue, Timothy J.

    2015-05-02

    Understanding the mechanisms of lipid accumulation in microorganisms is important for several reasons. In addition to providing insight into assembly of biological membranes, lipid accumulation has important applications in the production of renewable fuels and chemicals. The photosynthetic bacterium Rhodobacter sphaeroides is an attractive organism to study lipid accumulation, as it has the somewhat unique ability to increase membrane production at low O₂ tensions. Under these conditions, R. sphaeroides develops invaginations of the cytoplasmic membrane to increase its membrane surface area for housing of the membrane-bound components of its photosynthetic apparatus. Here we use fatty acid levels as a reportermore » of membrane lipid content. We show that, under low-O₂ and anaerobic conditions, the total fatty acid content per cell increases 3-fold. We also find that the increases in the amount of fatty acid and photosynthetic pigment per cell are correlated as O₂ tensions or light intensity are changed. To ask if lipid and pigment accumulation were genetically separable, we analyzed strains with mutations in known photosynthetic regulatory pathways. While a strain lacking AppA failed to induce photosynthetic pigment-protein complex accumulation, it increased fatty acid content under low O2 conditions. We also found that an intact PrrBA pathway is required for low O2-induced fatty acid accumulation. In conclusion, our findings suggest a previously unknown role of R. sphaeroides transcriptional regulators in increasing fatty acid and phospholipid accumulation in response to decreased O₂ tension.« less

  6. Slide 1

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Disposal Practices over the Years 1955 1961 2004 1955 1961 20 1955 1961 SESSION 6: REGULATORY PROCESS Nick Ceto U.S. DOE - RL 2 RCRA/CERCLA Process * Tri-Parties have reached a Tentative Agreement for new TPA Milestones that include 200-SW-2 OU. 200-SW-2 will continue as a stand alone Operable Unit for the purpose of investigation and remedy selection. - M-015-93A: Submit revised RFI/CMS/RI/FS 1 Work Plan for the 200-SW- 2 OU to Ecology by 12/31/2011 - M-015-93B: Submit RFI/CMS /RI/FS Report and

  7. High-impact innovations honored as R&D 100 Award finalists

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    High-impact innovations honored as R&D 100 Award finalists High-impact innovations honored as R&D 100 Award finalists Nine Los Alamos National Laboratory innovations were selected as finalists for the 2016 R&D 100 Awards. August 24, 2016 Pulak Nath, of Los Alamos National Laboratory, holds the Pulmonary Lung Model (PulMo). Pulak Nath, of Los Alamos National Laboratory, holds the Pulmonary Lung Model (PulMo). Contact Nick Njegomir Communications Office (505) 665-9394 Email The

  8. High-impact innovations honored as R&D 100 Award finalists

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Eight LANL technologies named 2016 R&D 100 Award finalists High-impact innovations honored as R&D 100 Award finalists Eight Los Alamos National Laboratory innovations were selected as finalists for the 2016 R&D 100 Awards. August 24, 2016 Pulak Nath Pulak Nath of Applied Modern Physics holds the Pulmonary Lung Model (PulMo). Contact Nick Njegomir Los Alamos National Laboratory (505)-665-9394 The Laboratory's R&D 100 Award finalists represent the breadth of scientific innovations

  9. SSRLUO 2002 Executive Committee Members | Stanford Synchrotron Radiation

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Lightsource 2 Executive Committee Members ENVIRONMENTAL/GEOSCIENCES Satish Myneni Princeton University Geoscience 151 Guyot Hall Princeton, NJ 08544 Phone: 609-258-5848 E-mail: smyneni@princeton.edu Nicholas Pingitore University of Texas at El Paso Environmental & Geosciences El Paso, TX 79968-0555 Phone: 915-747-5754 Fax: 915-747-5073 E-mail: nick@geo.utep.edu MACROMOLECULAR CRYSTALLOGRAPHY Paul Foster(ex-officio) UCSF/Exelixis Biophysics Box 0448 San Francisco, CA 94143 Phone:

  10. HERO Leavenworth Tree Lighting

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    HERO Leavenworth Shopping and Christmas Lighting Festival We'll take you, friends and family, to a Leavenworth that is particularly magical in the Christmas season. There is something for everyone, from roasted chestnuts at the gazebo, to shopping and sleigh rides...all just minutes away! And at dusk, everyone gathers to witness the lighting of a magical wonderland, as they light up the village and park. With a greeting from "Old Saint Nick" at the gazebo, the Leavenworth Christmas

  11. Five Los Alamos innovations win R&D 100 Awards

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    About the Lab » News Releases » News Releases - 2016 » November » Five Los Alamos innovations win R&D 100 Awards Five Los Alamos innovations win R&D 100 Awards The prestigious "Oscars of Invention" honor the latest and best innovations and identify the top technology products of the past year. November 15, 2016 Since 1978 Los Alamos has won 137 of the prestigious R&D 100 Awards. Since 1978 Los Alamos has won 137 of the prestigious R&D 100 Awards. Contact Nick

  12. Talk to the Magellan Staff at SC10 in New Orleans

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Talk to the Magellan Staff at SC10 in New Orleans Talk to the Magellan Staff at SC10 in New Orleans October 12, 2010 Magellan will be highlighted at a variety of workshops and talks at SC10. The Petascale Data Analytics on Clouds Workshop will include talks by Kathy Yelick, Shane Canon, and Nick Wright. On Wednesday, there will be a joint presentation with a collaborators at Argonne in the Argonne booth. That presentation will be followed by a talk in the Berkeley Lab booth (#2448) along with

  13. Heritage Is a Part of DOE Advisory Board Secretary's Interest in

    Office of Environmental Management (EM)

    Science Bowl | Department of Energy

    Henderson County North Middle School wins 2015 DOE West Kentucky Regional Science Bowl Henderson County North Middle School wins 2015 DOE West Kentucky Regional Science Bowl February 6, 2015 - 12:08pm Addthis 1st Place Henderson County North Middle School, from left: (Top) Deegan Lawrence, Coach Chris Fifer and D.J. Banks. (Bottom) Luke Payne, Alex Chandler and Nick Cissell (not pictured). 1st Place Henderson County North Middle School, from left:

  14. Ripples in space-time discussed in public lecture

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Ripples in space-time discussed in public lecture Ripples in space-time discussed in public lecture Gabriela Gonzalez will discuss the observation of gravitational waves at 7:30 p.m. Sept. 19 in Santa Fe. September 15, 2016 A simulation of two merging black holes, creating gravitational waves. Photo courtesy of LIGO. A simulation of two merging black holes, creating gravitational waves. Photo courtesy of LIGO. Contact Nick Njegomir Communications Office (505) 665-9394 Email "This is a very

  15. Nickel

    SciTech Connect

    Mastromatteo, E.

    1986-10-01

    Nickel was first isolated in impure form in 1751 by Cronstedt from an ore containing niccolite (NiAs). An ore of this type had earlier caused trouble in the smelting of copper and silver in Saxony, yielding an unusually brittle product. This interfering substance was referred to as kupfernick after Old Nick and his mischievous gnomes and Cronstedt applied the name nickel to this new element. The pure metal was first prepared by Richter in 1804 and he described some of the useful properties of nickel. This paper discusses the properties, sources, and toxicity of nickel.

  16. Method for assaying clustered DNA damages

    DOEpatents

    Sutherland, Betsy M.

    2004-09-07

    Disclosed is a method for detecting and quantifying clustered damages in DNA. In this method, a first aliquot of the DNA to be tested for clustered damages with one or more lesion-specific cleaving reagents under conditions appropriate for cleavage of the DNA to produce single-strand nicks in the DNA at sites of damage lesions. The number average molecular length (Ln) of double stranded DNA is then quantitatively determined for the treated DNA. The number average molecular length (Ln) of double stranded DNA is also quantitatively determined for a second, untreated aliquot of the DNA. The frequency of clustered damages (.PHI..sub.c) in the DNA is then calculated.

  17. Slide 1

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Focus on the Field Dr. Monica Regalbuto Assistant Secretary Office of Environmental Management www.energy.gov/EM 2 First-Hand Look at Fieldwork www.energy.gov/EM 3 Innovation in the Field "I haven't printed a procedure in months, and the device allows me to be more functional in the field. The other thing that's nice is that we are all on-call 24/7, so having the ability to log straight in at midnight when they call me, that's very beneficial." - Nick Balsmeier, Idaho Site

  18. 1

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    track Santa's magical journey December 20, 2010 LOS ALAMOS, New Mexico, December 20, 2010-For the 55th consecutive year, millions of people all over the world over will be able to keep tabs on Santa as he treks around the globe delivering presents to good girls and boys. And scientists from Los Alamos National Laboratory are again part of the effort! Los Alamos trackers will use state-of-the-art technology to mark the course taken by Old St. Nick and his reindeer; visit http://santa.lanl.gov

  19. This list does not imply DOE endorsement of the individuals or companies identif

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Process Heating Assessment and Survey Tool (PHAST) Qualified Specialists June 2016 Name E-mail Address Phone Number Location A Alaras, Art art_alaras@hillspet.com 785-231-2872 KS Atreya, Arvind aatreya@umich.edu 734-647-4790 MI Avagyan, Ruben ravagyan@mix.wvu.edu 304-906-1401 WV B Baesel, Bryan bbaesel@cec-consultants.com 216-749-2992 OH Baker, Mike mike.baker@hollyfrontier.com 801-643-3770 UT Balster, Nick nbalster@wyman.com 508-839-8103 MA Banta, Larry Larry.Banta@mail.wvu.edu 304-293-3375 WV

  20. Computation Study of Flow and Growth Inside Ammonothermal Gallium Nitride Reactor

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Rajeev Pakalapati (Soraa Inc.) Nick Killingsworth (LLNL) U.S. DOE Advanced Manufacturing Office Program Review Meeting Washington, D.C. June 14-15, 2016 This presentation does not contain any proprietary, confidential, or otherwise restricted information. Project Objective  Soraa is an LED-based lighting manufacturer and is the largest consumer of Gallium Nitride (GaN) wafers in the US  Soraa has invented a new reactor technology and process to produce GaN wafers at high quality and low

  1. Scientist in the Spotlight August 13

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Scientist in the Spotlight August 13 Scientist in the Spotlight August 13 WHEN: Aug 13, 2016 11:00 AM - 1:00 PM WHERE: Bradbury Science Museum 1350 Central Ave, Los Alamos, NM 87544, USA CONTACT: Linda Anderman (505) 665-9196 CATEGORY: Bradbury INTERNAL: Calendar Login Event Description A chance to chat and interact with Lab science types Forecasting disease Nick Generous, with the Lab's Information Systems and Modeling group, will be available to chat about how new social media tools help

  2. Los Alamos' David Mascareñas receives Presidential Early Career Award

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Mascareñas receives Presidential Early Career Award Los Alamos' David Mascareñas receives Presidential Early Career Award David Mascareñas was named a recipient of the Presidential Early Career Award by President Obama last week. February 24, 2016 David Mascareñas David Mascareñas Contact Nick Njegomir Communications Office (505) 665-9394 Email "David is an innovative engineer whose creative thinking is essential to the continuing success of Los Alamos' national-security science

  3. Brainstorming Apps for a Clean Energy Future | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Brainstorming Apps for a Clean Energy Future Brainstorming Apps for a Clean Energy Future July 20, 2012 - 1:03pm Addthis Notes from the July 9th Energy Data Jam in New York City | Credit: Openei.org Notes from the July 9th Energy Data Jam in New York City | Credit: Openei.org Nick Sinai U.S. Deputy Chief Technology Officer, White House Office of Science and Technology Policy Ian Kalin Director of the Energy Data Initiative How can I participate? You can contribute ideas for new products,

  4. Truman's decision to drop the bomb to be discussed at 70th anniversary

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    lecture July 10 70th anniversary lecture July 10 about Truman, bomb Truman's decision to drop the bomb to be discussed at 70th anniversary lecture July 10 Noel Pugach will discuss Truman's decision to drop atomic bombs on Japanese cities and explain how and why he made it July 3, 2013 70th anniversary lecture July 10 about Truman, bomb Noel Pugach will discuss Truman's decision to drop atomic bombs on Japanese cities and explain how and why he made it Contact Nick Njegomir Communications

  5. Super Wi-Fi is Super for Energy Too | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Wi-Fi is Super for Energy Too Super Wi-Fi is Super for Energy Too September 24, 2010 - 11:45am Addthis Super Wi-Fi is Super for Energy Too Nick Sinai U.S. Deputy Chief Technology Officer, White House Office of Science and Technology Policy What does this mean for me? By integrating broadband into the emerging Smart Grid, consumers will have revolutionized communication with their utility -- they will have detailed information on their energy use that will help inform them how they can save on

  6. Brainwaves as a Biometric Parameter for Unique Identification and

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Brainstorming Apps for a Clean Energy Future Brainstorming Apps for a Clean Energy Future July 20, 2012 - 1:03pm Addthis Notes from the July 9th Energy Data Jam in New York City | Credit: Openei.org Notes from the July 9th Energy Data Jam in New York City | Credit: Openei.org Nick Sinai U.S. Deputy Chief Technology Officer, White House Office of Science and Technology Policy Ian Kalin Director of the Energy Data Initiative How can I participate? You can contribute ideas for new products,

  7. Distinct kinetics of human DNA ligases I, IIIalpha, IIIbeta, and IV reveal direct DNA sensing ability and differential physiological functions in DNA repair

    SciTech Connect

    Chen, Xi; Ballin, Jeff D.; Della-Maria, Julie; Tsai, Miaw-Sheue; White, Elizabeth J.; Tomkinson, Alan E.; Wilson, Gerald M.

    2009-05-11

    The three human LIG genes encode polypeptides that catalyze phosphodiester bond formation during DNA replication, recombination and repair. While numerous studies have identified protein partners of the human DNA ligases (hLigs), there has been little characterization of the catalytic properties of these enzymes. In this study, we developed and optimized a fluorescence-based DNA ligation assay to characterize the activities of purified hLigs. Although hLigI joins DNA nicks, it has no detectable activity on linear duplex DNA substrates with short, cohesive single-strand ends. By contrast, hLigIII{beta} and the hLigIII{alpha}/XRCC1 and hLigIV/XRCC4 complexes are active on both nicked and linear duplex DNA substrates. Surprisingly, hLigIV/XRCC4, which is a key component of the major non-homologous end joining (NHEJ) pathway, is significantly less active than hLigIII on a linear duplex DNA substrate. Notably, hLigIV/XRCC4 molecules only catalyze a single ligation event in the absence or presence of ATP. The failure to catalyze subsequent ligation events reflects a defect in the enzyme-adenylation step of the next ligation reaction and suggests that, unless there is an in vivo mechanism to reactivate DNA ligase IV/XRCC4 following phosphodiester bond formation, the cellular NHEJ capacity will be determined by the number of adenylated DNA ligaseIV/XRCC4 molecules.

  8. Structure of an aprataxin?DNA complex with insights into AOA1 neurodegenerative disease

    SciTech Connect

    Tumbale, Percy; Appel, C. Denise; Kraehenbuehl, Rolf; Robertson, Patrick D.; Williams, Jessica S.; Krahn, Joe; Ahel, Ivan; Williams, R. Scott (NIEHS); (Manchester)

    2012-09-17

    DNA ligases finalize DNA replication and repair through DNA nick-sealing reactions that can abort to generate cytotoxic 5'-adenylation DNA damage. Aprataxin (Aptx) catalyzes direct reversal of 5'-adenylate adducts to protect genome integrity. Here the structure of a Schizosaccharomyces pombe Aptx-DNA-AMP-Zn{sup 2+} complex reveals active site and DNA interaction clefts formed by fusing a histidine triad (HIT) nucleotide hydrolase with a DNA minor groove-binding C{sub 2}HE zinc finger (Znf). An Aptx helical 'wedge' interrogates the base stack for sensing DNA ends or DNA nicks. The HIT-Znf, the wedge and an '[F/Y]PK' pivot motif cooperate to distort terminal DNA base-pairing and direct 5'-adenylate into the active site pocket. Structural and mutational data support a wedge-pivot-cut HIT-Znf catalytic mechanism for 5'-adenylate adduct recognition and removal and suggest that mutations affecting protein folding, the active site pocket and the pivot motif underlie Aptx dysfunction in the neurodegenerative disorder ataxia with oculomotor apraxia 1 (AOA1).

  9. SU-E-T-14: A Feasibility Study of Using Modified AP Proton Beam for Post-Operative Pancreatic Cancer Therapy

    SciTech Connect

    Ding, X; Witztum, A; Kenton, O; Younan, F; Dormer, J; Kremmel, E; Lin, H; Liu, H; Tang, S; Both, S; Kassaee, A; Avery, S

    2014-06-01

    Purpose: Due to the unpredictability of bowel gas movement, the PA beam direction is always favored for robust proton therapy in post-operative pancreatic cancer treatment. We investigate the feasibility of replacing PA beam with a modified AP beam to take the bowel gas uncertainty into account. Methods: Nine post-operative pancreatic cancer patients treated with proton therapy (5040cGy, 28 fractions) in our institution were randomly selected. The original plan uses PA and lateral direction passive-scattering proton beams. Beam weighting is about 1:1. All patients received weekly verification CTs to assess the daily variations(total 17 verification CTs). The PA direction beam was replaced by two other groups of AP direction beam. Group AP: takes 3.5% range uncertainty into account. Group APmod: compensates the bowel gas uncertainty by expanding the proximal margin to 2cm more. The 2cm margin was acquired from the average bowel diameter in from 100 adult abdominal CT scans near pancreatic region (+/- 5cm superiorly and inferiorly). Dose Volume Histograms(DVHs) of the verification CTs were acquired for robustness study. Results: Without the lateral beam, Group APmod is as robust as Group PA. In Group AP, more than 10% of iCTV D98/D95 were reduced by 4–8%. LT kidney and Liver dose robustness are not affected by the AP/PA beam direction. There is 10% of chance that RT kidney and cord will be hit by AP proton beam due to the bowel gas. Compared to Group PA, APmod plan reduced the dose to kidneys and cord max significantly, while there is no statistical significant increase in bowel mean dose. Conclusion: APmod proton beam for the target coverage could be as robust as the PA direction without sacrificing too much of bowel dose. When the AP direction beam has to be selected, a 2cm proximal margin should be considered.

  10. SU-E-P-57: Radiation Doses Assessment to Paediatric Patients for Some Digital Diagnostic Radiology Examination in Emergency Department in Qatar

    SciTech Connect

    Abdallah, I; Aly, A; Al Naemi, H

    2015-06-15

    Purpose: The aim of this study was to evaluate radiation doses to pediatric patients undergoing standard radiographic examinations using Direct Digital Radiography (DDR) in Paediatric emergency center of Hamad General Hospital (HGH) in state of Qatar and compared with regional and international Dose Reference Levels (DRLs). Methods: Entrance Skin Dose (ESD) was measured for 2739 patients for two common X-ray examinations namely: Chest AP/PA, Abdomen. Exposure factors such as kV, mAs and Focal to Skin Distance (FSD) were recorded for each patient. Tube Output was measured for a range of selected kV values. ESD for each individual patient was calculated using the tube output and the technical exposure factors for each examination. The ESD values were compared with the some international Dose Reference Levels (DRL) for all types of examinations. Results: The most performed procedure during the time of this study was chest PA/PA (85%). The mean ESD values obtained from AP chest, PA chest and AP abdomen ranged 91–120, 80–84 and 209 – 659 µGy per radiograph for different age’s groups respectively. Two protocols have been used for chest AP and PA using different radiological parameters, and the different of ESD values for chest PA and were 41% for 1 years old child, 57% for 5 years old for chest AP. Conclusion: The mean ESD were compared with those found in literature and were found to be comparable. The radiation dose can be reduced more for Chest AP and PA examination by optimization of each investigation and hence more studies are required for this task. The results presented will serve as a baseline data needed for deriving local reference doses for pediatric X-ray examinations in this local department and hence it can be applied in the whole Qatar.

  11. Oxygen-­dependent regulation of bacterial lipid production

    SciTech Connect

    Lemmer, Kimberly C.; Dohnalkova, Alice C.; Noguera, Daniel R.; Donohue, Timothy J.

    2015-05-02

    Understanding the mechanisms of lipid accumulation in microorganisms is important for several reasons. In addition to providing insight into assembly of biological membranes, lipid accumulation has important applications in the production of renewable fuels and chemicals. The photosynthetic bacterium Rhodobacter sphaeroides is an attractive organism to study lipid accumulation, as it has the somewhat unique ability to increase membrane production at low O₂ tensions. Under these conditions, R. sphaeroides develops invaginations of the cytoplasmic membrane to increase its membrane surface area for housing of the membrane-bound components of its photosynthetic apparatus. Here we use fatty acid levels as a reporter of membrane lipid content. We show that, under low-O₂ and anaerobic conditions, the total fatty acid content per cell increases 3-fold. We also find that the increases in the amount of fatty acid and photosynthetic pigment per cell are correlated as O₂ tensions or light intensity are changed. To ask if lipid and pigment accumulation were genetically separable, we analyzed strains with mutations in known photosynthetic regulatory pathways. While a strain lacking AppA failed to induce photosynthetic pigment-protein complex accumulation, it increased fatty acid content under low O2 conditions. We also found that an intact PrrBA pathway is required for low O2-induced fatty acid accumulation. In conclusion, our findings suggest a previously unknown role of R. sphaeroides transcriptional regulators in increasing fatty acid and phospholipid accumulation in response to decreased O₂ tension.

  12. All Hands Program Review Off-site | MIT-Harvard Center for Excitonics

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Review Off-site January 25, 2012 at 9am-7pm / MIT Endicott House IMG_4534 IMG_4500.02 IMG_4452 IMG_4410 (click images for a larger view) Time Presenter 8:30-9:00AM Continental Breakfast 9:00AM Opening remarks-Marc Baldo EFRC - Seeds 9:10AM Natalia Shustova 9:15AM David Ciudad 9:20AM YongJoo Kim 9:25AM Will Tisdale 9:30AM Q&A EFRC - 4 10:30-10:55AM Break EFRC - 3 10:55AM Priya Jadhav 11:00AM Phil Reusswig 11:05AM Jiye Lee 11:10AM Nick Thompson 11:15AM Paul Azunre 11:20AM Shane Yost 11:25AM

  13. Site directed recombination

    DOEpatents

    Jurka, Jerzy W.

    1997-01-01

    Enhanced homologous recombination is obtained by employing a consensus sequence which has been found to be associated with integration of repeat sequences, such as Alu and ID. The consensus sequence or sequence having a single transition mutation determines one site of a double break which allows for high efficiency of integration at the site. By introducing single or double stranded DNA having the consensus sequence flanking region joined to a sequence of interest, one can reproducibly direct integration of the sequence of interest at one or a limited number of sites. In this way, specific sites can be identified and homologous recombination achieved at the site by employing a second flanking sequence associated with a sequence proximal to the 3'-nick.

  14. Redox Non-Innocence of Nitrosobenzene at Nickel

    DOE PAGES [OSTI]

    Kundu, Subrata; Stieber, S. Chantal; Ferrier, Maryline Ghislaine; Kozimor, Stosh Anthony; Bertke, Jeffery A.; Warren, Timothy H.

    2016-07-29

    Nitrosobenzene (PhNO) serves as a stable analogue of nitroxyl (HNO), a biologically relevant, redox-active nitric oxide derivative. Capture of nitrosobenzene at the electrondeficient β-diketiminato nickel(I) complex [iPr2NNF6]Ni results in reduction of the PhNO ligand to a (PhNO)./ ⁻ species coordinated to a square planar NiII center in [iPr2NNF6]Ni(η2- ONPh). Ligand centered reduction leads to the (PhNO)-2 moiety bound to NiII supported by XAS studies. Ultimately, systematic investigation of structure–reactivity patterns of (PhNO)./ ⁻ and (PhNO)2- ligands reveals parallels with superoxo (O2)./ ⁻ and peroxo (O2)2- ligands, respectively, and forecasts reactivity patterns of the more transient HNO ligand.

  15. Coal combustion waste management at landfills and surface impoundments 1994-2004.

    SciTech Connect

    Elcock, D.; Ranek, N. L.; Environmental Science Division

    2006-09-08

    disposal practices and State regulatory requirements at landfills and surface impoundments that were permitted, built, or laterally expanded between January 1, 1994, and December 31, 2004. The scope of the study excluded waste units that manage CCWs in active or abandoned coal mines. The EPA identified the following three areas of interest: (1) Recent and current CCW industry surface disposal management practices, (2) State regulatory requirements for CCW management, and (3) Implementation of State requirements (i.e., the extent to which States grant or deny operator requests to waive or vary regulatory requirements and the rationales for doing so). DOE and the EPA obtained data on recent and current disposal practices from a questionnaire that the Utility Solid Waste Activities Group (USWAG) distributed to its members that own or operate coal-fired power plants. USWAG, formed in 1978, is responsible for addressing solid and hazardous waste issues on behalf of the utility industry. It is an informal consortium of approximately 80 utility operating companies, the Edison Electric Institute (EEI), the National Rural Electric Cooperative Association (NRECA), the American Public Power Association (APPA), and the American Gas Association (AGA). EEI is the principal national association of investor-owned electric power and light companies. NRECA is the national association of rural electric cooperatives. APPA is the national association of publicly owned electric utilities. AGA is the national association of natural gas utilities. Together, USWAG member companies and trade associations represent more than 85% of the total electric generating capacity of the United States and service more than 95% of the nation's consumers of electricity. To verify the survey findings, the EPA also asked State regulators from nine selected States that are leading consumers of coal for electricity generation for information on disposal units that may not have been covered in the USWAG survey. The

  16. Measurement Practices for Reliability and Power Quality

    SciTech Connect

    Kueck, JD

    2005-05-06

    This report provides a distribution reliability measurement ''toolkit'' that is intended to be an asset to regulators, utilities and power users. The metrics and standards discussed range from simple reliability, to power quality, to the new blend of reliability and power quality analysis that is now developing. This report was sponsored by the Office of Electric Transmission and Distribution, U.S. Department of Energy (DOE). Inconsistencies presently exist in commonly agreed-upon practices for measuring the reliability of the distribution systems. However, efforts are being made by a number of organizations to develop solutions. In addition, there is growing interest in methods or standards for measuring power quality, and in defining power quality levels that are acceptable to various industries or user groups. The problems and solutions vary widely among geographic areas and among large investor-owned utilities, rural cooperatives, and municipal utilities; but there is still a great degree of commonality. Industry organizations such as the National Rural Electric Cooperative Association (NRECA), the Electric Power Research Institute (EPRI), the American Public Power Association (APPA), and the Institute of Electrical and Electronics Engineers (IEEE) have made tremendous strides in preparing self-assessment templates, optimization guides, diagnostic techniques, and better definitions of reliability and power quality measures. In addition, public utility commissions have developed codes and methods for assessing performance that consider local needs. There is considerable overlap among these various organizations, and we see real opportunity and value in sharing these methods, guides, and standards in this report. This report provides a ''toolkit'' containing synopses of noteworthy reliability measurement practices. The toolkit has been developed to address the interests of three groups: electric power users, utilities, and regulators. The report will also serve

  17. Nuclear translocation and overexpression of GAPDH by the hyper-pressure in retinal ganglion cell

    SciTech Connect

    Kim, Choong-Il; Lee, Sung-Ho; Seong, Gong-Je; Kim, Yeon-Hyang; Lee, Mi-Young . E-mail: miyoung@sch.ac.kr

    2006-03-24

    To investigate the effect of hyper-pressure on retinal ganglion cells (RGC-5), RGC-5 cells were exposed to an ambient hydrostatic pressure of 100 mm Hg. Upon treatment, the proliferation of RGC-5 cells was inhibited and neuronal apoptosis was detected by specific apoptosis marker TUNEL (terminal deoxynucleotidyl transferase dUTP nick-end labeling). To probe into the mechanism mediating the apoptosis of RGC-5 cells in 100 mm Hg, protein profile alterations following hyper-pressure treatment were examined using two-dimensional gel electrophoresis (2-DE) followed by MALDI-TOF. Out of the 400 protein spots of RGC-5 cells detected on 2-DE gels, 37 differentially expressed protein spots were further identified using in gel tryptic digestion and mass spectrometry. Among these proteins, glyceraldehyde-3-phosphate-dehydrogenase (GAPDH) was significantly expressed 10 times more in 100 mm Hg than in normal pressure. The accumulation of GAPDH in the nucleus and its translocation from the cytosol to the nucleus in 100 mm Hg were observed using a microscope. These results suggest that the hyper-pressure-induced apoptosis in RGC-5 cells may be involved with not only the increase of GAPDH expression, but also the accumulation and the translocalization of GAPDH to the nucleus.

  18. Trichodermin induces cell apoptosis through mitochondrial dysfunction and endoplasmic reticulum stress in human chondrosarcoma cells

    SciTech Connect

    Su, Chen-Ming; Wang, Shih-Wei; Lee, Tzong-Huei; Tzeng, Wen-Pei; Hsiao, Che-Jen; Liu, Shih-Chia; Tang, Chih-Hsin

    2013-10-15

    Chondrosarcoma is the second most common primary bone tumor, and it responds poorly to both chemotherapy and radiation treatment. Nalanthamala psidii was described originally as Myxosporium in 1926. This is the first study to investigate the anti-tumor activity of trichodermin (trichothec-9-en-4-ol, 12,13-epoxy-, acetate), an endophytic fungal metabolite from N. psidii against human chondrosarcoma cells. We demonstrated that trichodermin induced cell apoptosis in human chondrosarcoma cell lines (JJ012 and SW1353 cells) instead of primary chondrocytes. In addition, trichodermin triggered endoplasmic reticulum (ER) stress protein levels of IRE1, p-PERK, GRP78, and GRP94, which were characterized by changes in cytosolic calcium levels. Furthermore, trichodermin induced the upregulation of Bax and Bid, the downregulation of Bcl-2, and the dysfunction of mitochondria, which released cytochrome c and activated caspase-3 in human chondrosarcoma. In addition, animal experiments illustrated reduced tumor volume, which led to an increased number of terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL)-positive cells and an increased level of cleaved PARP protein following trichodermin treatment. Together, this study demonstrates that trichodermin is a novel anti-tumor agent against human chondrosarcoma cells both in vitro and in vivo via mitochondrial dysfunction and ER stress. - Highlights: Trichodermin induces chondrosarcoma apoptosis. ER stress is involved in trichodermin-induced cell death. Trichodermin induces chondrosarcoma death in vivo.

  19. Hydraulic and Clean-in-Place Evaluations for a 12.5-cm Annular Centrifugal Contactor at INL

    SciTech Connect

    Troy G. Garn; David H. Meikrantz; Nick R. Mann; Jack D. Law; Terry A. Todd

    2008-09-01

    Hydraulic and Clean-in-Place Evaluations for a 12.5 cm Annular Centrifugal Contactor at the INL Troy G. Garn, Dave H. Meikrantz, Nick R. Mann, Jack D. Law, Terry A. Todd Idaho National Laboratory Commercially available, Annular Centrifugal Contactors (ACC) are currently being evaluated for processing dissolved nuclear fuel solutions to selectively partition integrated elements using solvent extraction technologies. These evaluations include hydraulic and clean-in-place (CIP) testing of a commercially available 12.5 cm unit. Data from these evaluations is used to support design of future nuclear fuel reprocessing facilities. Hydraulic testing provides contactor throughput performance data on two-phase systems for a wide range of operating conditions. Hydraulic testing results on a simple two-phase oil and water system followed by a 30 % Tributyl phosphate in N-dodecane / nitric acid pair are reported. Maximum total throughputs for this size contactor ranged from 20 to 32 liters per minute without significant other phase carryover. A relatively new contactor design enhancement providing Clean-in-Place capability for ACCs was also investigated. Spray nozzles installed into the central rotor shaft allow the rotor internals to be cleaned, offline. Testing of the solids capture of a diatomaceous earth/water slurry feed followed by CIP testing was performed. Solids capture efficiencies of >95% were observed for all tests and short cold water cleaning pulses proved successful at removing solids from the rotor.

  20. Crystal Structure of the Phage T4 Recombinase UvsX and Its Functional Interaction with the T4 SF2 Helicase UvsW

    SciTech Connect

    Gajewski, Stefan; Webb, Michael R.; Galkin, Vitold; Egelman, Edward H.; Kreuzer, Kenneth N.; White, Stephen W.

    2012-07-11

    Bacteriophage T4 provides an important model system for studying the mechanism of homologous recombination. We have determined the crystal structure of the T4 UvsX recombinase, and the overall architecture and fold closely resemble those of RecA, including a highly conserved ATP binding site. Based on this new structure, we reanalyzed electron microscopy reconstructions of UvsX-DNA filaments and docked the UvsX crystal structure into two different filament forms: a compressed filament generated in the presence of ADP and an elongated filament generated in the presence of ATP and aluminum fluoride. In these reconstructions, the ATP binding site sits at the protomer interface, as in the RecA filament crystal structure. However, the environment of the ATP binding site is altered in the two filament reconstructions, suggesting that nucleotide cannot be as easily accommodated at the protomer interface of the compressed filament. Finally, we show that the phage helicase UvsW completes the UvsX-promoted strand-exchange reaction, allowing the generation of a simple nicked circular product rather than complex networks of partially exchanged substrates.

  1. Expression of hPNAS-4 Radiosensitizes Lewis Lung Cancer

    SciTech Connect

    Zeng Hui; Yuan Zhu; Zhu Hong; Li Lei; Shi Huashan; Wang Zi; Fan Yu; Deng Qian; Zeng Jianshuang; He Yinbo; Xiao Jianghong; Li Zhiping

    2012-11-15

    Purpose: This study aimed to transfer the hPNAS-4 gene, a novel apoptosis-related human gene, into Lewis lung cancer (LL2) and observe its radiosensitive effect on radiation therapy in vitro and in vivo. Methods and Materials: The hPNAS-4 gene was transfected into LL2 cells, and its expression was detected via western blot. Colony formation assay and flow cytometry were used to detect the growth and apoptosis of cells treated with irradiation/PNAS-4 in vitro. The hPNAS-4 gene was transferred into LL2-bearing mice through tail vein injection of the liposome/gene complex. The tumor volumes were recorded after radiation therapy. Proliferating cell nuclear antigen (PCNA) immunohistochemistry staining and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay were performed to detect the tumor cell growth and apoptosis in vivo. Results: The hPNAS-4 gene was successfully transferred into LL2 cells and tumor tissue, and its overexpressions were confirmed via western blot analysis. Compared with the control, empty plasmid, hPNAS-4, radiation, and empty plasmid plus radiation groups, the hPNAS-4 plus radiation group more significantly inhibited growth and enhanced apoptosis of LL2 cells in vitro and in vivo (P<.05). Conclusions: The hPNAS-4 gene was successfully transferred into LL2 cells and tumor tissue and was expressed in both LL2 cell and tumor tissue. The hPNAS-4 gene therapy significantly enhanced growth inhibition and apoptosis of LL2 tumor cells by radiation therapy in vitro and in vivo. Therefore, it may be a potential radiosensitive treatment of radiation therapy for lung cancer.

  2. SL-01, an oral gemcitabine derivative, inhibited human cancer growth more potently than gemcitabine

    SciTech Connect

    Zhao, Cuirong; Yue, Bin; Liu, Huiping; Sun, Cuicui; Li, Wenbao; Qu, Xianjun

    2012-08-01

    SL-01, an oral gemcitabine derivative, was synthesized by introducing the moiety of 3-(dodecyloxycarbonyl)pyrazine-2-carbonyl at the N4-position on the cytidine ring of gemcitabine. Our goal in this study was to evaluate the efficacy of SL-01 on the growth of human cancers with gemcitabine as control. Experiments were performed on human non-small cell lung cancer NCI-H460 and colon cancer HCT-116 both in vitro and in vivo. In vitro assays, SL-01 significantly inhibited the growth of cancer cells as determined by the 3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide (MTT) assay. Further studies indicated that SL-01 induced the cancer cells to apoptosis showing chromatin condensation and externalization of phosphatidylserine. In in vivo studies, we evaluated the efficacy of SL-01 in nude mice bearing human cancer xenografts. SL-01 effectively delayed the growth of NCI-H460 and HCT-116 without significant loss of body weight. Molecular analysis indicated that the high efficacy of SL-01 was associated with its ability to induce apoptosis as evidenced by increase of terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining cells, activation of caspase-9, caspase-3 and cleaved poly ADP-ribose polymerase (PARP) in tumor tissues. SL-01 also increased Bax/Bcl-2 ratio in cancer cells. These biological activities of SL-01 were more potential than that of gemcitabine. Based on these in vitro and in vivo results, SL-01 is proposed as a potent oral anticancer agent that may supplant the use of gemcitabine in the clinic. -- Highlights: ► An oral gemcitabine derivative SL-01 was synthesized. ► The effects of SL-01 were evaluated and its efficacy was compared with gemcitabine. ► The biological activities of SL-01 were more potent than that of gemcitabine. ► SL-01 could replace gemcitabine for clinical use.

  3. Novel DNA packaging recognition in the unusual bacteriophage N15

    SciTech Connect

    Feiss, Michael; Geyer, Henriette; Klingberg, Franco; Moreno, Norma; Forystek, Amanda; Maluf, Nasib Karl; Sippy, Jean

    2015-08-15

    Phage lambda's cosB packaging recognition site is tripartite, consisting of 3 TerS binding sites, called R sequences. TerS binding to the critical R3 site positions the TerL endonuclease for nicking cosN to generate cohesive ends. The N15 cos (cos{sup N15}) is closely related to cos{sup λ}, but whereas the cosB{sup N15} subsite has R3, it lacks the R2 and R1 sites and the IHF binding site of cosB{sup λ}. A bioinformatic study of N15-like phages indicates that cosB{sup N15} also has an accessory, remote rR2 site, which is proposed to increase packaging efficiency, like R2 and R1 of lambda. N15 plus five prophages all have the rR2 sequence, which is located in the TerS-encoding 1 gene, approximately 200 bp distal to R3. An additional set of four highly related prophages, exemplified by Monarch, has R3 sequence, but also has R2 and R1 sequences characteristic of cosB–λ. The DNA binding domain of TerS-N15 is a dimer. - Highlights: • There are two classes of DNA packaging signals in N15-related phages. • Phage N15's TerS binding site: a critical site and a possible remote accessory site. • Viral DNA recognition signals by the λ-like bacteriophages: the odd case of N15.

  4. Final Technical Report Microwave Assisted Electrolyte Cell for Primary Aluminum Production

    SciTech Connect

    Xiaodi Huang; J.Y. Hwang

    2007-04-18

    This research addresses the high priority research need for developing inert anode and wetted cathode technology, as defined in the Aluminum Industry Technology Roadmap and Inert Anode Roadmap, with the performance targets: a) significantly reducing the energy intensity of aluminum production, b) ultimately eliminating anode-related CO2 emissions, and c) reducing aluminum production costs. This research intended to develop a new electrometallurgical extraction technology by introducing microwave irradiation into the current electrolytic cells for primary aluminum production. This technology aimed at accelerating the alumina electrolysis reduction rate and lowering the aluminum production temperature, coupled with the uses of nickel based superalloy inert anode, nickel based superalloy wetted cathode, and modified salt electrolyte. Michigan Technological University, collaborating with Cober Electronic and Century Aluminum, conducted bench-scale research for evaluation of this technology. This research included three sub-topics: a) fluoride microwave absorption; b) microwave assisted electrolytic cell design and fabrication; and c) aluminum electrowinning tests using the microwave assisted electrolytic cell. This research concludes that the typically used fluoride compound for aluminum electrowinning is not a good microwave absorbing material at room temperature. However, it becomes an excellent microwave absorbing material above 550C. The electrowinning tests did not show benefit to introduce microwave irradiation into the electrolytic cell. The experiments revealed that the nickel-based superalloy is not suitable for use as a cathode material; although it wets with molten aluminum, it causes severe reaction with molten aluminum. In the anode experiments, the chosen superalloy did not meet corrosion resistance requirements. A nicked based alloy without iron content could be further investigated.

  5. p53 Mutation suppresses adult neurogenesis in medaka fish (Oryzias latipes)

    SciTech Connect

    Isoe, Yasuko; Okuyama, Teruhiro; Taniguchi, Yoshihito; Kubo, Takeo; Takeuchi, Hideaki

    2012-07-13

    Highlights: Black-Right-Pointing-Pointer Progenitor migration is accompanied by an increase in their numbers in the adult brain. Black-Right-Pointing-Pointer p53 Mutation suppressed an increase in the number of the migrated progenitors. Black-Right-Pointing-Pointer The decreased progenitor number is not due to enhanced cell death. Black-Right-Pointing-Pointer p53 Mutation did not affect proliferation of stem cells. -- Abstract: Tumor suppressor p53 negatively regulates self-renewal of neural stem cells in the adult murine brain. Here, we report that the p53 null mutation in medaka fish (Oryzias latipes) suppressed neurogenesis in the telencephalon, independent of cell death. By using 5-bromo-29-deoxyuridine (BrdU) immunohistochemistry, we identified 18 proliferation zones in the brains of young medaka fish; in situ hybridization showed that p53 was expressed selectively in at least 12 proliferation zones. We also compared the number of BrdU-positive cells present in the whole telencephalon of wild-type (WT) and p53 mutant fish. Immediately after BrdU exposure, the number of BrdU-positive cells did not differ significantly between them. One week after BrdU-exposure, the BrdU-positive cells migrated from the proliferation zone, which was accompanied by an increased number in the WT brain. In contrast, no significant increase was observed in the p53 mutant brain. Terminal deoxynucleotidyl transferase (dUTP) nick end-labeling revealed that there was no significant difference in the number of apoptotic cells in the telencephalon of p53 mutant and WT medaka, suggesting that the decreased number of BrdU-positive cells in the mutant may be due to the suppression of proliferation rather than the enhancement of neural cell death. These results suggest that p53 positively regulates neurogenesis via cell proliferation.

  6. Methyl-parathion decreases sperm function and fertilization capacity after targeting spermatocytes and maturing spermatozoa

    SciTech Connect

    Pina-Guzman, Belem; Sanchez-Gutierrez, M.; Marchetti, Francesco; Hernandez-Ochoa, I.; Solis-Heredia, M.J .; Quintanilla-Vega, B.

    2009-05-03

    Paternal germline exposure to organophosphorous pesticides (OP) has been associated with reproductive failures and adverse effects in the offspring. Methyl parathion (Me-Pa), a worldwide-used OP, has reproductive adverse effects and is genotoxic to sperm. Oxidative damage has been involved in the genotoxic and reproductive effects of OP. The purpose of this study was to determine the effects of Me-Pa on spermatozoa function and ability to fertilize. Male mice were exposed to Me-Pa (20 mg/kg bw, i.p.) and spermatozoa from epididymis-vas deferens were collected at 7 or 28 days post-treatment (dpt) to assess the effects on maturing spermatozoa and spermatocytes, respectively. DNA damage was evaluated by nick translation (NT-positive cells) and SCSA (percentDFI); lipoperoxidation (LPO) by malondialdehyde production; sperm function by spontaneous- and induced-acrosome reactions (AR); mitochondrial membrane potential (MMP) by using the JC-1 flurochrome; and, fertilization ability by an in vitro assay and in vivo mating. Results showed alterations in DNA integrity (percentDFI and NT-positive cells) at 7 and 28 dpt, in addition to decreased sperm quality and a decrease in induced-AR; reduced MMP and LPO was observed only at 7 dpt. We found negative correlations between LPO and all sperm alterations. Altered sperm functional parameters were associated with reduced fertilization rates at both times, evaluated either in vitro or in vivo. These results show that Me-Pa exposure of maturing spermatozoa and spermatocytes affects many sperm functional parameters that result in a decreased fertilizing capacity. Oxidative stress seems to be a likely mechanism ofthe detrimental effects of Me-Pa in male germ cells.

  7. Synthesis, structure, magnetism and nuclease activity of tetranuclear copper(II) phosphonates contatining ancillary 2,2'-bipyridine or 1,10-phenanthroline ligands

    SciTech Connect

    Chandrasekhar, V.; Azhakar, R.; Senapati, T.; Thilagar, P.; Gosh, S.; Verma, S.; Boomishankar, R.; Steiner, A.; Kogerler, P.

    2008-01-07

    The reaction of cyclohexylphosphonic acid (C{sub 6}H{sub 11}PO{sub 3}H{sub 2}), anhydrous CuCl{sub 2} and 2,2{prime}-bipyridine (bpy) in the presence of triethylamine followed by a metathesis reaction with KNO{sub 3} afforded [Cu{sub 4}({micro}-Cl){sub 2}({micro}{sub 3}-C{sub 6}H{sub 11}PO{sub 3}){sub 2}(bpy){sub 4}](NO{sub 3}){sub 2} (1). In an analogous reaction involving Cu(OAc){sub 2} {center_dot} H{sub 2}O, the complex [Cu{sub 4}({micro}-CH{sub 3}COO){sub 2}({micro}{sub 3}-C{sub 6}H{sub 11}PO{sub 3}){sub 2}(2,2-bpy){sub 4}](CH{sub 3}COO){sub 2} (2) has been isolated. The three-component reaction involving Cu(NO{sub 3}){sub 2} {center_dot} 3H{sub 2}O, cyclohexylphosphonic acid and 2,2{prime}-bipyridine in the presence of triethylamine afforded the tetranuclear assembly [Cu{sub 4}({micro}-OH)({micro}{sub 3}-C{sub 6}H{sub 11}PO{sub 3}){sub 2}(2,2{prime}-bpy){sub 4} (H{sub 2}O){sub 2}](NO{sub 3}){sub 3} (3). Replacing 2,2{prime}-bipyridine with 1,10-phenanthroline (phen) in the above reaction resulted in [Cu{sub 4}({micro}-OH)({micro}{sub 3}-C{sub 6}H{sub 11}PO{sub 3}){sub 2}(phen){sub 4}(H{sub 2}O){sub 2}](NO{sub 3}){sub 3} (4). In all the copper(II) phosphonates (1-4) the two phosphonate ions bridge the four copper(II) ions in a capping coordination action. Each phosphonate ion bridges four copper(II) ions in a {micro}{sub 4}, coordination mode or 4.211 of the Harris notation. Variable-temperature magnetic studies on 1-4 reveal that all four complexes exhibit moderately strong intramolecular antiferromagnetic coupling. The DNA cleavage activity of complexes 1-4 is also described. Compounds 1 and 3 were able to completely convert the supercoiled pBR322 DNA form I to nick form II without any co-oxidant. In contrast, 50% conversion occurred with 2 and 40% with 4. In the presence of magnesium monoperoxyphthalate all four compounds achieved rapid conversion of form I to form II.

  8. Secure IRC Server

    Energy Science and Technology Software Center

    2003-08-25

    The IRCD is an IRC server that was originally distributed by the IRCD Hybrid developer team for use as a server in IRC message over the public Internet. By supporting the IRC protocol defined in the IRC RFC, IRCD allows the users to create and join channels for group or one-to-one text-based instant messaging. It stores information about channels (e.g., whether it is public, secret, or invite-only, the topic set, membership) and users (who ismore » online and what channels they are members of). It receives messages for a specific user or channel and forwards these messages to the targeted destination. Since server-to-server communication is also supported, these targeted destinations may be connected to different IRC servers. Messages are exchanged over TCP connections that remain open between the client and the server. The IRCD is being used within the Pervasive Computing Collaboration Environment (PCCE) as the 'chat server' for message exchange over public and private channels. After an LBNLSecureMessaging(PCCE chat) client has been authenticated, the client connects to IRCD with its assigned nickname or 'nick.' The client can then create or join channels for group discussions or one-to-one conversations. These channels can have an initial mode of public or invite-only and the mode may be changed after creation. If a channel is public, any one online can join the discussion; if a channel is invite-only, users can only join if existing members of the channel explicity invite them. Users can be invited to any type of channel and users may be members of multiple channels simultaneously. For use with the PCCE environment, the IRCD application (which was written in C) was ported to Linux and has been tested and installed under Linux Redhat 7.2. The source code was also modified with SSL so that all messages exchanged over the network are encrypted. This modified IRC server also verifies with an authentication server that the client is who he or she claims to be and

  9. Student Travel to Pan-Am Congress of Plants & Biofuels in Merida, Mexico

    SciTech Connect

    Kimberly, Kimnach

    2014-04-01

    Department of Energy – Final Technical Report Grant Title: Student Travel to Pan-Am Congress of Plants & Biofuels in Merida, Mexico Award #: DE-FG02-08ER64612 Award Amount: $15,000.00 Award period: 6/15/2008 to 6/14/2009 ______________________________________________________________________________ The Pan American Congress on Plants and BioEnergy convened in Mérida, Mexico, June 22 to 25, 2008. The program was organized by Steve Long (University of Illinois) and Nick Carpita (Purdue University), along with co-organizers Marcos Buckeridge (University of São Paulo, Brazil) and Federico Sánchez (Universidad Nacional Autónoma de México). More than 200 scientists from over a dozen nations around the world gathered to discuss key issues surrounding the development of biofuel feedstocks and to report on their research in this area. This three day conference had invited speakers surrounding developing renewable and sustainable energy resources which are typically propelled by three important drivers – security, cost and environmental impact. The first day of the conference was delegated to governmental policy makers and designers of national research and plant biologists, agronomists, microbiologists, economists and ecologists in relation to bioenergy security in the Western Hemisphere that is sustainable and ecologically and economically sound. Speakers from countries that have already made themselves energy independent shared solutions to improve efficiency that is being researched. Venture capitalist and industry leaders also spoke on their commitment to economic success in a new green agroindustry. Days two and three explored bioenergy crops and introduced the participants to the breadth of the agricultural landscape, the underlying biology of bioenergy plants and new ideas to enhance biomass yield and quality of the energy crops of the future. These presentations educated the participants in an effort to develop energy strategies in countries across the