National Library of Energy BETA

Sample records for nf lrmp fs

  1. IL FS Ecosmart Ltd | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Services Product: IL&FS Ecosmart Ltd., a subsidiary of the Infrastructure Leasing & Financial Services (IL&FS) Group, provides environmental services. References: IL&FS...

  2. FS65 Disposition Option Report

    SciTech Connect (OSTI)

    Wenz, Tracy R.

    2015-09-25

    This report outlines the options for dispositioning the MOX fuel stored in FS65 containers at LANL. Additional discussion regarding the support equipment for loading and unloading the FS65 transport containers is included at the end of the report.

  3. NF Energy Saving Corp | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    NF Energy Saving Corp Jump to: navigation, search Name: NF Energy Saving Corp Place: Shenyang, Liaoning Province, China Sector: Services Product: China-based company provides...

  4. Financial Statement: IG-FS-CA-06-04

    Energy.gov [DOE]

    Review of Actions to Correct Financial Control and Reporting Weaknesses; Audit Report No: OAS-FS/CA-06-04

  5. Fs-laser processing of polydimethylsiloxane

    SciTech Connect (OSTI)

    Atanasov, Petar A. Nedyalkov, Nikolay N.; Valova, Eugenia I.; Georgieva, Zhenya S.; Armyanov, Stefan A.; Kolev, Konstantin N.; Amoruso, Salvatore; Wang, Xuan; Bruzzese, Ricardo; Sawczak, Miroslaw; Śliwiński, Gerard

    2014-07-14

    We present an experimental analysis on surface structuring of polydimethylsiloxane films with UV (263 nm) femtosecond laser pulses, in air. Laser processed areas are analyzed by optical microscopy, SEM, and μ-Raman spectroscopy. The laser-treated sample shows the formation of a randomly nanostructured surface morphology. μ-Raman spectra, carried out at both 514 and 785 nm excitation wavelengths, prior and after laser treatment allow evidencing the changes in the sample structure. The influence of the laser fluence on the surface morphology is studied. Finally, successful electro-less metallization of the laser-processed sample is achieved, even after several months from the laser-treatment contrary to previous observation with nanosecond pulses. Our findings address the effectiveness of fs-laser treatment and chemical metallization of polydimethylsiloxane films with perspective technological interest in micro-fabrication devices for MEMS and nano-electromechanical systems.

  6. MarFS-Requirements-Design-Configuration-Admin

    SciTech Connect (OSTI)

    Kettering, Brett Michael; Grider, Gary Alan

    2015-07-08

    This document will be organized into sections that are defined by the requirements for a file system that presents a near-POSIX (Portable Operating System Interface) interface to the user, but whose data is stored in whatever form is most efficient for the type of data being stored. After defining the requirement the design for meeting the requirement will be explained. Finally there will be sections on configuring and administering this file system. More and more, data dominates the computing world. There is a “sea” of data out there in many different formats that needs to be managed and used. “Mar” means “sea” in Spanish. Thus, this product is dubbed MarFS, a file system for a sea of data.

  7. Financial Statement: OAS-FS-07-02 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    OAS-FS-07-02 Financial Statement: OAS-FS-07-02 November 13, 2006 Department of Energy's Fiscal Year 2006 Consolidated Balance Sheet Report: OAS-FS-07-02 (850.69 KB) More Documents ...

  8. Audit Report: OAS-FS-14-04 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    4 Audit Report: OAS-FS-14-04 December 20, 2013 Management Letter: Federal Energy ... More Documents & Publications Audit Report: OAS-FS-13-07 Audit Report: OAS-FS-12-04 Audit ...

  9. Audit Report: CR-FS-97-02 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    FS-97-02 Audit Report: CR-FS-97-02 May 1, 1997 Audit of the Department of Energy's Consolidated Financial Statements for Fiscal Year 1996 Audit Report: CR-FS-97-02 More Documents &...

  10. Financial Statement: OAS-FS-07-02 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    OAS-FS-07-02 November 13, 2006 Department of Energy's Fiscal Year 2006 Consolidated Balance Sheet Report: OAS-FS-07-02 More Documents & Publications Audit Report: OAS-FS-07-02...

  11. Report: WR-FS-99-02 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Report: WR-FS-99-02 Report: WR-FS-99-02 April 7, 1999 Report on Matters Identified at the Albuquerque Operations Office During the Audit of the Department of Energy's Consolidated Fiscal Year 1998 Financial Statements The Government Management Reform Act of 1994 requires that the Department of Energy (DOE) annually submit audited financial statements to the Office of Management and Budget (OMB). A DOE-wide audit was conducted to determine whether there was reasonable assurance that DOE's

  12. Financial Statement: OAS-FS-13-10 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    13-10 Financial Statement: OAS-FS-13-10 OUO Not Available for Viewing More Documents & Publications Audit Report: OAS-FS-13-10 Audit Report: OAS-FS-13-07 Audit Report: OAS-FS-14-04

  13. Audit Report: OAS-FS-11-04 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    4 Audit Report: OAS-FS-11-04 December 21, 2010 Information Technology Management Letter on the Audit of the Department of Energy's Consolidated Balance Sheet for Fiscal Year 2010 (OUO Not Available for Viewing) More Documents & Publications Audit Report: OAS-FS-12-04 Audit Report: OAS-FS-13-10 Audit Report: OAS-FS-13

  14. Audit Report: OAS-FS-12-04 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    4 Audit Report: OAS-FS-12-04 December 21, 2011 Information Technology Management Letter on the Audit of the Department of Energy's Consolidated Balance Sheet for Fiscal Year 2011 (OUO Not Available for Viewing) More Documents & Publications Audit Report: OAS-FS-11-04 Audit Report: OAS-FS-13-10 Audit Report: OAS-FS-13-07

  15. Audit Report: OAS-FS-13-07 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    07 Audit Report: OAS-FS-13-07 December 3, 2012 Management Letter on the Federal Energy Regulatory Commission's Fiscal Year 2012 Financial Statement Audit (OUO Not Available for Viewing) More Documents & Publications Audit Report: OAS-FS-14-04 Audit Report: OAS-FS-12-04 Audit Report: OAS-FS-11-04

  16. Audit Report: OAS-FS-10-05 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    5 Audit Report: OAS-FS-10-05 February 18, 2010 Uranium Enrichment Decontamination and Decommissioning Fund's Fiscal Year 2008 and 2007 Financial Statement Audit Audit Report: OAS-FS-10-05 (778.3 KB) More Documents & Publications Uranium Enrichment Decontamination and Decommissioning Fund's Fiscal Year 2008 and 2007 Financial Statement Audit, OAS-FS-10-05 Audit Report: OAS-FS-09-06 Audit Report: OAS-FS-09-02

  17. GlusterFS One Storage Server to Rule Them All

    SciTech Connect (OSTI)

    Boyer, Eric B.; Broomfield, Matthew C.; Perrotti, Terrell A.

    2012-07-30

    GlusterFS is a Linux based distributed file system, designed to be highly scalable and serve many clients. Some reasons to use GlusterFS are: No centralized metadata server, Scalability, Open Source, Dynamic and live service modifications, Can be used over Infiniband or Ethernet, Can be tuned for speed and/or resilience and Flexible administration. It's useful for enterprise environments - virtualization; high performance computing (HPC) and it works with Mac, Linux and Windows clients. Conclusions are: (1) GlusterFS proved to have widespread capabilities as a virtual file system; (2) Scalability is very dependent upon the underlying hardware; (3) Lack of built-in encryption and security paradigm; and (4) Best suited in a general purpose computing environment.

  18. Audit Report: CR-FS-99-01

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    MANAGEMENT REPORT AUDIT OF THE DEPARTMENT OF ENERGY'S CONSOLIDATED FINANCIAL STATEMENTS FOR FISCAL YEAR 1998 Report Number: CR-FS-99-01 Capital Regional Audit Office Date of Issue: June 15, 1999 Germantown, MD 20874 MANAGEMENT REPORT AUDIT OF THE DEPARTMENT OF ENERGY'S CONSOLIDATED FINANCIAL STATEMENTS FOR FISCAL YEAR 1998 TABLE OF CONTENTS Page SUMMARY.................................................................................. 1 PART I - APPROACH AND

  19. Audit Report: AP-FS-97-02 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    FS-97-02 Audit Report: AP-FS-97-02 June 6, 1997 Audit of Departmental Integrated Standardized Core Accounting System (DISCAS) Operations at Selected Field Sites Audit Report: ...

  20. Audit Report: OAS-FS-13-05 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    5 Audit Report: OAS-FS-13-05 November 28, 2012 Department of Energy's Nuclear Waste Fund's ... Topic: Management & Administration Audit Report: OAS-FS-13-05 (601.24 KB) More Documents & ...

  1. Audit Report: ER-FS-99-03 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    3 Audit Report: ER-FS-99-03 May 25, 1999 Matters Identified at the Savannah River ... Audit Report: ER-FS-99-03 (19.56 KB) More Documents & Publications Audit Report: ...

  2. Audit Report: OAS-FS-13-04 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    4 Audit Report: OAS-FS-13-04 November 15, 2012 Department of Energy's Fiscal Year 2012 ... Topic: Management & Administration Audit Report: OAS-FS-13-04 (444.01 KB) More Documents & ...

  3. Audit Report: WR-FS-96-01 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Audit Report: WR-FS-96-01 Audit Report: WR-FS-96-01 March 18, 1996 Report on Matters Identified at the Richland Operations Office During the Audit of the Department's Consolidated ...

  4. Audit Report: OAS-FS-09-01 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    09-01 Audit Report: OAS-FS-09-01 November 13, 2008 Report on the Department of Energy's ... Fnancial Statements Audit Report: OAS-FS-09-01 (586.82 KB) More Documents & ...

  5. Finanacial Statement: WR-FS-99-01 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Finanacial Statement: WR-FS-99-01 Finanacial Statement: WR-FS-99-01 March 1999 Report on Matters Identified at The Idaho Operations Office during The Audit of The Department's ...

  6. Audit Report: OAS-FS-13-03 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    3 Audit Report: OAS-FS-13-03 November 15, 2012 The Federal Energy Regulatory Commission's ... Topic: Management & Administration Audit Report: OAS-FS-13-03 (407.6 KB) More Documents & ...

  7. Audit Report: OAS-FS-10-01 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    1 Audit Report: OAS-FS-10-01 November 9, 2009 Report on "Federal Energy Regulatory ... (rev. 09292009) Audit Report: OAS-FS-10-01 (95.65 KB) More Documents & ...

  8. Financial Statement: WR-FS-09-04 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    WR-FS-09-04 Financial Statement: WR-FS-09-04 May 17, 1999 Report on Matters Identified at the Oakland Operations Office during the Audit of The Department of Energy's Consolidated ...

  9. Audit Report: OAS-FS-07-02 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    7-02 Audit Report: OAS-FS-07-02 November 13, 2006 Report on the Department of Energy's ... Audit Report: OAS-FS-07-02 (664.82 KB) More Documents & Publications Financial Statement: ...

  10. Audit Report: OAS-FS-12-02 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    2 Audit Report: OAS-FS-12-02 November 15, 2011 Department of Energy's Fiscal Year 2011 ... Audit Report: OAS-FS-12-02 (205.23 KB) More Documents & Publications Audit Report: ...

  11. Audit Report: OAS-FS-08-02 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    8-02 Audit Report: OAS-FS-08-02 November 9, 2007 Report on the Department of Energy's ... Audit Report: OAS-FS-08-02 (1.5 MB) More Documents & Publications Audit Report: ...

  12. Audit Report: CR-FS-96-03 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Audit Report: CR-FS-96-03 April 15, 1996 Report on Matters Identified at Strategic Petroleum Reserve During Audit of Statement of Financial Position Audit Report: CR-FS-96-03 ...

  13. Audit Report: IG-FS-97-01 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    report please email the report number to: igwebmaster@hq.doe.gov More Documents & Publications Audit Report: IG-FS-98-01 Financial Statement: IG-FS-01-01 Audit Report: ER-B-97-03...

  14. Audit Report: OAS-FS-14-05 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    5 Audit Report: OAS-FS-14-05 January 9, 2014 Information Technology Management Letter on the Audit of the Department of Energy's Consolidated Balance Sheet for Fiscal Year 2013 OUO not available for viewing Topic: Management & Administration More Documents & Publications Audit Report: OAS-FS-15-06 Audit Report: OAS-FS-13-10 Audit Report: OAS-FS-12

  15. Audit Report: IG-FS-96-01 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    6-01 Audit Report: IG-FS-96-01 February 29, 1996 Audit of The U.S. Department of Energy's Consolidated Statement of Financial Position (as of September 30, 1995) Audit Report: IG-FS-96-01 (94.78 KB) More Documents & Publications Audit Report: WR-FS-96-01 Audit Report: WR-FS-97-03 Baseline Environmental Management Report (BEMR) in 1995

  16. Audit Report: OAS-FS-13-10 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    0 Audit Report: OAS-FS-13-10 January, 10, 2013 Information Technology Management Letter on the Audit of the Department of Energy's Consolidated Balance Sheet for Fiscal Year 2012 (OUO Not Available for Viewing) Topic: National Security & Safety More Documents & Publications Audit Report: OAS-FS-12-04 Audit Report: OAS-FS-11-04 Audit Report: OAS-FS-13-07

  17. Audit Report: OAS-FS-06-01 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    6-01 Audit Report: OAS-FS-06-01 November 14, 2005 Report o the Department of Energy's ... 2005 Consolidated Financial Statements, OAS-FS-06-01 Audit Report: OAS-FS-06-01 (691.79 ...

  18. Audit Report: OAS-FS-12-05 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    5 Audit Report: OAS-FS-12-05 February 6, 2012 Audit of the Department of Energy's Consolidated Financial Statements for Fiscal Year 2011 Consolidated financial statements of the United States Department of Energy (Department or DOE) as of and for the year ended September 30, 2011, and have issued our report thereon dated November 14, 2011. Audit Report: OAS-FS-12-05 (216.9 KB) More Documents & Publications Audit Report: OAS-FS-13-08 Audit Report: OAS-FS-14-06 Audit Report: OAS-FS-11-05

  19. Audit Report: WR-FS-96-01 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Audit Report: WR-FS-96-01 Audit Report: WR-FS-96-01 March 18, 1996 Report on Matters Identified at the Richland Operations Office During the Audit of the Department's Consolidated Statement of Financial Position as of September 30, 1995 Audit Report: WR-FS-96-01 (55.23 KB) More Documents & Publications Audit Report: WR-FS-97-03 Audit Report: WR-FS-97-04 Semiannual Report to Congress: October 1, 1995 - March 31, 1996

  20. Quarry residuals RI/FS scoping document. [Weldon Spring quarry

    SciTech Connect (OSTI)

    Not Available

    1991-10-01

    The purpose of this document is to serve as a planning tool for the implementation of the Quarry Residual Remedial Investigation/Feasibility Study (RI/FS) process and to provide direct input to revising and updating the 1988 Work Plan for the Weldon Spring Site Remedial Action Project (WSSRAP) Remedial Investigation/Feasibility Study-Environmental Impact Statement for the Weldon Spring Site (RI/FS-EIS) (Peterson et al. 1988) for this effort. The scoping process is intended to outline the tasks necessary to develop and implement activities in compliance with the Comprehensive Environmental Response, Compensation and Liability Act-National Environmental Policy Act (CERCLA-NEPA) process from detailed planning through the appropriate decision document. In addition to scoping the entire process, this document will serve as the primary tool for planning and accomplishing all activities to be developed in the Quarry Residual RI/FS Work Plan. Subsequent tasks are difficult to plan at this time. 10 refs., 5 figs., 5 tabs.

  1. ARM - VAP Product - aerich1nf1turn

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Productsaerinfaerich1nf1turn Documentation Data Management Facility Plots (Quick Looks) Citation DOI: 10.5439/1027272 [ What is this? ] Generate Citation ARM Data Discovery Browse Data Comments? We would love to hear from you! Send us a note below or call us at 1-888-ARM-DATA. Send VAP Output : AERICH1NF1TURN AERI ch. 1

  2. ARM - VAP Product - aerich2nf1turn

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Productsaerinfaerich2nf1turn Documentation Data Management Facility Plots (Quick Looks) Citation DOI: 10.5439/1027273 [ What is this? ] Generate Citation ARM Data Discovery Browse Data Comments? We would love to hear from you! Send us a note below or call us at 1-888-ARM-DATA. Send VAP Output : AERICH2NF1TURN AERI ch. 2

  3. Portsmouth RI/FS Report for the Process Buildings and Complex Facilities

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Decontamination and Decommissioning Evaluation Project | Department of Energy Process Buildings and Complex Facilities Decontamination and Decommissioning Evaluation Project Portsmouth RI/FS Report for the Process Buildings and Complex Facilities Decontamination and Decommissioning Evaluation Project This remedial investigation/feasibility study (RI/FS), the Remedial Investigation and Feasibility Study Report for the Process Buildings and Complex Facilities Decontamination and

  4. CMRR-NF Supplemental EIS Scoping Comments | National Nuclear Security

    National Nuclear Security Administration (NNSA)

    Administration | (NNSA) CMRR-NF Supplemental EIS Scoping Comments CMRR-NF Supplemental EIS Scoping Comments Additional CMRR Scoping Comments - 47A Additional CMRR Scoping Comments - 48A Additional CMRR Scoping Comments - 62 Additional CMRR Scoping Comments - 63 Additional CMRR Scoping Comments - 64 Additional CMRR Scoping Comments - 66A Additional CMRR Scoping Comments - 66B Additional CMRR Scoping Comments - 66C Additional CMRR Scoping Comments - 76 Additional CMRR Scoping Comments - 77

  5. USFS Electric Transmission Line Easement Form FS-2700-31 | Open...

    Open Energy Information (Open El) [EERE & EIA]

    USFS Electric Transmission Line Easement Form FS-2700-31 Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- OtherOther: USFS Electric Transmission...

  6. Audit Report: OAS-FS-13-06 | Department of Energy

    Energy Savers

    sheets of the Southwestern Federal Power System (SWFPS) as of September 30, 2011 and ... Topic: Management & Administration PDF icon Audit Report: OAS-FS-13-06 More Documents & ...

  7. Audit Report: OAS-FS-11-02 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    1-02 Audit Report: OAS-FS-11-02 November 9, 2010 Federal Energy Regulary commission's Fiscal Year 2010 Financial Statement Audit The report presents the results of the independent certified public accountants' audit of the Federal Energy Regulatory Commission's (Commission) Fiscal Year 2010 balance sheet and the related statements of net cost, changes in net position, budgetary resources, and custodial activity. Audit Report: OAS-FS-11-02 (80.19 KB) More Documents & Publications Audit

  8. Audit Report OAS-FS-15-09 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Report OAS-FS-15-09 Audit Report OAS-FS-15-09 February 24, 2015 Audit of Costs Incurred Under the Department of Energy's International Nuclear Cooperation Program Interagency Agreements With the Department of State The Department of Energy's Office of Inspector General contracted with an independent certified public accounting firm, KPMG, LLP (KPMG), to determine the allowability, allocability and reasonableness of direct project costs incurred related to the International Nuclear Cooperation

  9. Audit Report: OAI-FS-17-02 | Department of Energy

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    OAI-FS-17-02 Audit Report: OAI-FS-17-02 November 15, 2016 Department of Energy's Fiscal Year 2016 Consolidated Financial Statements Pursuant to requirements established by the Government Management Reform Act of 1994, the Office of Inspector General engaged the independent public accounting firm of KPMG LLP (KPMG) to perform the audit of the Department of Energy's Fiscal Year 2016 Consolidated Financial Statements. KPMG audited the consolidated financial statements of the Department as of

  10. Audit Report: OAS-FS-11-03 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    3 Audit Report: OAS-FS-11-03 November 15, 2010 Office of Civilian Radioactive Waste Management's Fiscal Year 2010 Financial Statement Audit Report No The attached report presents the results of the independent certified public accountants' audit of the Office of Civilian Radioactive Waste Management's (OCRWM) Fiscal Year 2010 balance sheet and the related statements of net cost, changes in net position, and budgetary resources. Audit Report: OAS-FS-11-03 (260.67 KB) More Documents &

  11. Audit Report: OAS-FS-11-07 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    7 Audit Report: OAS-FS-11-07 June 14, 2011 Uranium Enrichment Decontamination and Decommissioning Fund's Fiscal Year 2010 The attached report presents the results of the independent certified public accountants' audit of the United States Department of Energy's Uranium Enrichment Decontamination and Decommissioning Fund's (D&D Fund) Fiscal Year (FY) 2010 balance sheet and the related statements of net cost, changes in net position, and budgetary resources. Audit Report: OAS-FS-11-07 (170.67

  12. Audit Report: OAS-FS-12-06 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    6 Audit Report: OAS-FS-12-06 March 8, 2012 Southwestern Federal Power System's Fiscal Year 2006, 2007, 2008 and 2009 Financial Statement Audits Results of the independent certified public accountant's audits of the Southwestern Federal Power System's (SWFPS) Fiscal Year 2009, 2008, 2007 and 2006 combined balance sheets and the related combined statements of revenues and expenses, changes in net Federal investment, and cash flows. Audit Report: OAS-FS-12-06 (1.13 MB) More Documents &

  13. Audit Report: WR-FS-99-01 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    FS-99-01 Audit Report: WR-FS-99-01 March 16, 1999 Report On Mater Identified At the Idaho Operations Office During The Audit Of The Department's Consolidated Fiscal Year 1998 Financial Statements The Government Management Reform Act of 1994 requires that the Department of Energy (DOE) annually submit audited financial statements to the Office of Management and Budget (OMB). A Departmentwide audit was conducted to determine whether there was reasonable assurance that DOE's consolidated Fiscal

  14. Audit Report: OAI-FS-17-01 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    FS-17-01 Audit Report: OAI-FS-17-01 October 31, 2016 Management Letter on the Southwestern Federal Power System's Fiscal Year 2015 Financial Statement Audit KPMG LLP (KPMG), our contract auditors, planned and performed an audit of the combined financial statements of the Southwestern Federal Power System (the System) as of and for the year ended September 30, 2015, in accordance with auditing standards generally accepted in the United States of America and the standards applicable to financial

  15. Remedial Investigation/Feasibility Study (RI/FS) process, elements and techniques guidance

    SciTech Connect (OSTI)

    Not Available

    1993-12-01

    This manual provides detailed guidance on Remedial Investigation/Feasibility Studies (RI/FSs) conducted pursuant to the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) at Department of Energy (DOE) facilities. The purpose of the RI/FS, to assess the risk posed by a hazardous waste site and to determine the best way to reduce that risk, and its structure (site characterization, risk assessment, screening and detailed analysis of alternatives, etc.) is defined in the National Oil and Hazardous Substances Pollution Contingency Plan (NCP) and further explained in the Environmental Protection Agency`s (EPA`s) Guidance for Conducting Remedial Investigations and Feasibility Studies Under CERCLA (Interim Final) 540/G-89/004, OSWER Directive 9355.3-01, October 1988. Though issued in 1988, the EPA guidance remains an excellent source of information on the conduct and structure of an RI/FS. This document makes use of supplemental RI/FS-related guidance that EPA has developed since its initial document was issued in 1988, incorporates practical lessons learned in more than 12 years of experience in CERCLA hazardous site remediation, and drawing on those lessons, introduces the Streamlined Approach For Environmental Restoration (SAFER), developed by DOE as a way to proceed quickly and efficiently through the RI/FS process at DOE facilities. Thus as its title implies, this guidance is intended to describe in detail the process and component elements of an RI/FS, as well as techniques to manage the RI/FS effectively.

  16. A proposed outline and review schedule for an integrated FS-EIS

    SciTech Connect (OSTI)

    Ambrose, R.; Cunningham, M.; Hanrahan, T. )

    1993-01-01

    Both CERCLA and NEPA have specific requirements for the information content, format, and review schedule of their respective Feasibility Study (FS) and Environmental Impact Statement (EIS) documents. The FS serves as the mechanism for the development, screening, and detailed evaluation of alternative remedial actions, while the EIS provides a discussion of significant environmental impacts and presents alternatives which would avoid or minimize adverse impacts or enhance the quality of the human environment. In some cases, the CERCLA and NEPA processes have been expressed as functionally equivalent'', and the need for NEPA questioned in instances where CERCLA compliance is required. This argument has been presented on the grounds that the CERCLA process addresses the information content needs of NEPA. However, in cases where EIS documents are required, specific information needs that are called for under NEPA are not typically addressed or readily fitted into the FS format (e.g. socioeconomic impacts). In addition, review schedules for an FS and an EIS differ; public comment opportunities and length of comment period differ. Where certain Federal agencies require that CERCLA and NEPA be integrated, there is often the guidance that NEPA be fitted into the CERCLA process. Using this guidance, an outline has been developed which integrates the information content needs of an FS and EIS, while maintaining, as closely as possible, the integrity of the FS format.

  17. Influence of process changes on PCDD/Fs produced in an iron ore sintering plant

    SciTech Connect (OSTI)

    Guerriero, E.; Bianchini, M.; Gigliucci, P.F.; Guarnieri, A.; Mosca, S.; Rossetti, G.; Varde, M.; Rotatori, M.

    2009-01-15

    This study investigated the influence of different charge typologies and additives on the PCDD/Fs amount produced and on the congener profiles in an iron ore sintering plant. Many tests were carried out combining different typologies of charge (iron materials) and solid fuel ('coke breeze' or 'anthracite') with or without the use of urea. The PCDD/Fs produced ranged from 1.2 to 22.7 {mu} g I-TEQ/ton of agglomerate, whereas the PCDD/Fs released to the ambient air ranged from 0.10 to 1.92 ng I-TEQ/Nm{sup 3} because of cleaning in an electrostatic precipitator (ESP) and a Wetfine scrubber (WS). A more homogeneous charge with a higher amount of fine particles charge appeared to produce a lower PCDD/Fs concentration due to a better combustion but this hypothesis needs further investigations on charges having different dimension particles. Only a synergitic action of urea and anthracite was able to reduce the high PCDD/Fs content due to the bad combustion of the more inhomogeneous charge with a lower amount of fine particles. The congener profile was a typical combustion process fingerprint because the PCDFs predominated, the highly chlorinated congeners (HeptaCDD and OctaCDD) prevailed in PCDDs, whereas in PCDFs the profile was more varied; 1,2,3,4,6,7,8-HeptaCDF was the main contributor to the total concentration while 2,3,4,7,8-PentaCDF was the main contributor to the I-TEQ concentration. Whereas all the parameters under scrutiny influenced strongly the amount of PCDD/Fs produced, they affected only slightly the fingerprint of PCDD/Fs. In all cases studied, the reduction obtained using urea, anthracite, or the more homogeneous charge with a higher amount of fine particles was slightly greater on the higher chlorinated congeners in respect to the lower ones.

  18. Audit Report: OAS-FS-10-03 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    3 Audit Report: OAS-FS-10-03 December 22, 2009 Management Letter on the Audit of the Department of Energy's Consolidated Financial Statements for Fiscal Year 2009 A.12a (Pre-SAS 115) Letter to communicate significant deficiencies and/or material weaknesses in internal control over financial reporting noted in an audit of financial statements of a nonpublic entity, excluding FDICIA engagements (Rev. 1/08) Audit Report: OAS-FS-10-03 (268.55 KB) More Documents & Publications Audit Report:

  19. AUDIT REPORT: OAI-FS-16-08 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    AUDIT REPORT: OAI-FS-16-08 AUDIT REPORT: OAI-FS-16-08 April 21, 2016 The Department of Energy's Improper Payment Reporting in the Fiscal Year 2015 Agency Financial Report This report presents the results of an audit of the Department of Energy's Improper Payment Reporting in the Fiscal Year 2015 Agency Financial Report. To fulfill the Office of Inspector General's audit responsibilities, we contracted with the independent public accounting firm of KPMG LLP (KPMG) to express an opinion on whether

  20. 100-D/H Operable Units RI/FS - Hanford Site

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Documents 100-D/H Operable Units RI/FS Documents 100-D/H Operable Units RI/FS Email Email Page | Print Print Page | Text Increase Font Size Decrease Font Size Remedial Investigation/Feasibility Study for the 100-DR-1, 100-DR-2, 100-HR-1, 100-HR-2, and 100-HR-3 Operable Units, DOE/RL-2010-95, Rev 0 Executive Summary (PDF) Table of Contents (PDF) Chapters 1-3 (PDF) Chapters 4-5 (PDF) Chapters 6-7 (PDF) Chapters 8-11 (PDF) Appendices A through O: Appendix A- Site Maps (PDF) Appendix B -

  1. Ultrafast gigantic photo-response in (EDO-TTF)2PF6 initiated by 10-fs laser pulses

    SciTech Connect (OSTI)

    Schoenlein, Robert William; Itatani, Jiro; Rini, Matteo; Cavalleri, Andrea; Onda, Ken; Ishikawa, Tadahiko; Koshihara, Shin-ya; Shao, Xiangfeng; Yamochi, Hideki; Saito, Gunzi; Schoenlein, Robert W.

    2006-08-07

    We photo-exited a charge-ordered organic salt (EDO-TTF)2PF6 with sub-10-fs optical pulses. The photo-induced metallic phase appeared within 80-fs after pumping, characterized by large changes in reflectivity (DELTA R/R~0.8) followed by strong coherent phonon modulation

  2. IDS-NF Impact of Neutrino Cross Section Impact of Neutrino Cross Section

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    IDS-NF Impact of Neutrino Cross Section Impact of Neutrino Cross Section Knowledge on Oscillation Knowledge on Oscillation Measurements Measurements M. Sorel, IFIC (CSIC and U. of Valencia) IDS-NF, RAL, Jan 16-17 2008 M. Sorel - IFIC (Valencia U. & CSIC) 2 IDS-NF Neutrino Cross Sections: At What Energies Needed? Superbeams: Solid: T2K Dashed: NovA M. Sorel - IFIC (Valencia U. & CSIC) 3 IDS-NF Neutrino Cross Sections: At What Energies Needed? Superbeams: Solid: T2K Dashed: NovA Beta

  3. Audit Report: OAS-FS-13-02 | Department of Energy

    Energy Savers

    2 Audit Report: OAS-FS-13-02 September 7, 2012 Management Letter on the Uranium Enrichment Decontamination and Decommissioning Fund's Fiscal Year 2011 Financial Statement Audit The Office of Inspector General (OIG) engaged the independent public accounting firm of KPMG, LLP (KPMG) to perform an audit of the United States Department of Energy's Uranium Enrichment Decontamination and Decommissioning (D&D) Fund's FY 2011 financial statements. KPMG concluded that the financial statements present

  4. Southwestern Federal Power System's Fiscal Year 2010 Financial Statement Audit, OAS-FS-12-10

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Audit Report Southwestern Federal Power System's Fiscal Year 2010 Financial Statement Audit OAS-FS-12-10 July 2012 Department of Energy Washington, DC 20585 July 30, 2012 MEMORANDUM FOR THE ADMINISTRATOR, SOUTHWESTERN POWER ADMINISTRATION FROM: Daniel M. Weeber Assistant Inspector General for Audits and Administration Office of Inspector General SUBJECT: INFORMATION: Southwestern Federal Power System's Fiscal Year 2010 Financial Statement Audit The attached report present the results of the

  5. Southwestern Federal Power System's Fiscal Year 2011 Financial Statement Audit, OAS-FS-13-06

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Southwestern Federal Power System's Fiscal Year 2011 Financial Statement Audit OAS-FS-13-06 November 2012 U.S. Department of Energy Office of Inspector General Office of Audits & Inspections Department of Energy Washington, DC 20585 November 29, 2012 MEMORANDUM FOR THE ADMINISTRATOR, SOUTHWESTERN POWER ADMINISTRATION FROM: Daniel M. Weeber Assistant Inspector General for Audits and Administration Office of Inspector General SUBJECT: INFORMATION: Audit Report on "Southwestern Federal

  6. Audit Report: CR-FS-99-01 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    9-01 Audit Report: CR-FS-99-01 June 15, 1999 Management Report Audit of the Department of Energy's Consolidated Financial Statements for Fiscal Year 1998 As required by the Government Management Reform Act of 1994, we audited the U.S. Department of Energy's (Department) consolidated financial statements as of and for the years ended September 30, 1998 and 1997 to determine whether they presented fairly, in all material respects, the Department's financial position, net cost, changes in net

  7. Audit Report: ER-FS-99-04 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    4 Audit Report: ER-FS-99-04 May 27, 1999 Results of Audit Procedures Performed at the Strategic Petroleum Reserve During the Audit of the Department's Consolidated Fiscal Year 1998 Financial Statements The Government Management Reform Act of 1994 requires that audited financial statements covering all accounts and associated activities of the Department be submitted annually to the Office of Management and Budget. A Departmentwide audit of the consolidated Fiscal Year 1998 financial statements

  8. Audit Report: OAS-FS-12-08 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    8 Audit Report: OAS-FS-12-08 March 28, 2012 Department of Energy's Isotope Development and Production for Research and Applications Program's Fiscal Year 2009 Balance Sheet Audit We contracted with the independent public accounting firm of KPMG, LLP (KPMG) to express an opinion on the Department of Energy's Isotope Development and Production for Research and Applications Program's Fiscal Year 2009 Balance Sheet. KPMG concluded that, except for insufficient evidence to support inventories held

  9. Audit Report: OAS-FS-12-09 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    9 Audit Report: OAS-FS-12-09 June 22, 2012 Management Letter on the Department of Energy's Isotope Development and Production for Research and Applications Program's Fiscal Year 2009 Balance Sheet Audit This management letter, prepared by KPMG, LLP (our contract auditors), contained three new findings and seven recommendations that were issued during the course of the Department of Energy's Isotope Development and Production for Research and Applications Program's Fiscal Year 2009 Balance Sheet

  10. Audit Report: OAS-FS-13-08 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    8 Audit Report: OAS-FS-13-08 December 17, 2012 Management Letter on the Audit of the Department of Energy's Consolidated Financial Statements for Fiscal Year 2012 KPMG, LLP noted certain matters involving internal control and other operational matters during their audit of the Department of Energy's (Department) Consolidated Financial Statements for Fiscal Year (FY) 2012. These matters are intended to improve the Department's internal controls or result in other operational efficiencies. The

  11. Audit Report: OAS-FS-13-09 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    9 Audit Report: OAS-FS-13-09 January 15, 2013 Department of Energy's Isotope Development and Production for Research and Applications Program's Fiscal Year 2010 Balance Sheet Audit We contracted with the independent public accounting firm of KPMG, LLP (KPMG) to express an opinion on the Department of Energy's Isotope Development and Production for Research and Applications Program's (Isotope Program) Fiscal Year 2010 Balance Sheet. KPMG concluded that the Isotope Program's balance sheet as of

  12. Audit Report: OAS-FS-13-12 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    2 Audit Report: OAS-FS-13-12 March 14, 2013 Performance Audit of the Department of Energy's Improper Payment Reporting in the Fiscal Year 2012 Agency Financial Report We contracted with an independent public accounting firm, KPMG LLP, to express an opinion on whether the Department of Energy (Department) met the Office of Management and Budget's criteria for compliance with the Improper Payments Elimination and Recovery Act (IPERA). The objective of this audit was to complete an evaluation of

  13. Audit Report: OAS-FS-13-13 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    3 Audit Report: OAS-FS-13-13 August 12, 2013 Southwestern Federal Power System's Fiscal Year 2012 Financial Statement Audit We contracted with the independent public accounting firm of KPMG LLP (KPMG) to conduct the audit the Southwestern Federal Power System's (SWFPS) financial statements and reporting on applicable internal controls and compliance with laws and regulations. KPMG concluded that the combined financial statements present fairly, in all material respects, the respective financial

  14. Audit Report: OAS-FS-14-01 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    1 Audit Report: OAS-FS-14-01 November 25, 2013 Federal Energy Regulatory Commission's Fiscal Year 2013 Financial Statement Audit The Office of Inspector General contracted with the independent public accounting firm of KPMG, LLP (KPMG) to conduct the audit, subject to our review. KPMG is responsible for expressing an opinion on the Commission's financial statements and reporting on applicable internal controls and compliance with laws and regulations. The Office of Inspector General monitored

  15. Audit Report: OAS-FS-14-02 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    2 Audit Report: OAS-FS-14-02 Wednesday, December 11, 2013 Department of Energy's Nuclear Waste Fund's Fiscal Year 2013 Financial Statement Audit The Office of Inspector General contracted with the independent public accounting firm of KPMG, LLP (KPMG) to conduct an audit of the Department of Energy's Nuclear Waste Fund's Fiscal Year 2013 balance sheet and the related statements of net cost, changes in net position and combined statements of budgetary resources. KPMG concluded that the financial

  16. Audit Report: OAS-FS-14-03 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    3 Audit Report: OAS-FS-14-03 December 12, 2013 Department of Energy's Fiscal Year 2013 Consolidated Financial Statements Pursuant to requirements established by the Government Management Reform Act of 1994, the Office of Inspector General engaged the independent public accounting firm of KPMG, LLP (KPMG) to perform the audit of the Department of Energy's Fiscal Year 2013 Consolidated Financial Statements. KPMG audited the consolidated financial statements of the Department as of September 30,

  17. Audit Report: OAS-FS-14-06 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    6 Audit Report: OAS-FS-14-06 February 20, 2014 Management Letter on the Audit of the Department of Energy's Consolidated Financial Statements for Fiscal Year 2013 During the audit, KPMG, LLP (KPMG), our contract auditors, noted certain matters involving internal control and other operational matters. These comments and recommendations are intended to improve internal control or result in other operating efficiencies. Additionally, KPMG identified certain deficiencies in internal controls that it

  18. Portsmouth RI/FS Report for the Site-Wide Waste Disposition Evaluation

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Project | Department of Energy Site-Wide Waste Disposition Evaluation Project Portsmouth RI/FS Report for the Site-Wide Waste Disposition Evaluation Project This Remedial Investigation and Feasibility Study Report for the Site-Wide Waste Disposition Evaluation Project at the Portsmouth Gaseous Diffusion Plant, Piketon, Ohio, presents the information necessary to select a Site-wide disposal alternative for the waste generated under the Director's Final Findings and Orders (DFF&O) for

  19. Audit Report: OAI-FS-16-01 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    1 Audit Report: OAI-FS-16-01 November 16, 2015 Department of Energy's Fiscal Year 2015 Consolidated Financial Statements Pursuant to requirements established by the Government Management Reform Act of 1994, the Office of Inspector General engaged the independent public accounting firm of KPMG LLP (KPMG) to perform the audit of the Department of Energy's Fiscal Year 2015 Consolidated Financial Statements. KPMG audited the consolidated financial statements of the Department as of September 30,

  20. Audit Report: OAI-FS-16-02 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    2 Audit Report: OAI-FS-16-02 November 18, 2015 Federal Energy Regulatory Commission's Fiscal Year 2015 Financial Statement Audit This report presents the results of the independent certified public accountants' audit of the balance sheets of the Federal Energy Regulatory Commission (Commission), as of September 30, 2015 and 2014, and the related statements of net cost, changes in net position, budgetary resources, and custodial activity for the years then ended. To fulfill Office of Inspector

  1. Audit Report: OAI-FS-16-04 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    4 Audit Report: OAI-FS-16-04 January 7, 2016 Management Letter on the Federal Energy Regulatory Commission's Fiscal Year 2015 Financial Statement During the audit, KPMG, LLP (KPMG), our contract auditors, noted certain matters involving internal control and other operational matters. These comments and recommendations are intended to improve internal control or result in other operating efficiencies. KPMG noted two new findings that were issued during the course of the audit, and Management

  2. Audit Report: OAI-FS-16-05 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    5 Audit Report: OAI-FS-16-05 January 7, 2015 Information Technology Management Letter on the Audit of the Department of Energy's Consolidated Balance Sheet for Fiscal Year 2015 During the audit, KPMG, LLP (KPMG), noted certain matters involving internal control and other operational matters. These comments and recommendations are intended to improve internal controls or result in other operating efficiencies. Management concurred with and provided planned corrective actions for the

  3. Audit Report: OAI-FS-16-06 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    6 Audit Report: OAI-FS-16-06 January 15, 2016 Management Letter on the Audit of the Department of Energy's Consolidated Financial Statements for Fiscal Year 2015 During the audit, KPMG LLP (KPMG), our contract auditors, noted certain matters involving internal control and other operational matters. These comments and recommendations are intended to improve internal control or result in other operating efficiencies. In addition, KPMG identified a deficiency in internal control related to the

  4. Audit Report: OAI-FS-16-07 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    7 Audit Report: OAI-FS-16-07 April 6, 2016 Western Federal Power System's Fiscal Year 2015 Financial Statement Audit This report presents the results of the independent certified public accountants' audit of the Western Federal Power System's (Western) combined balance sheets, as of September 30, 2015 and 2014, and the related combined statements of changes in capitalization, revenues and expenses, and cash flows for the years then ended. To fulfill the Office of Inspector General's (OIG) audit

  5. Audit Report: OAI-FS-16-09 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    09 Audit Report: OAI-FS-16-09 May 6, 2016 Management Letter on the Western Federal Power System's Fiscal Year 2015 Financial Statement Audit KPMG LLP (KPMG), our contract auditors, planned and performed an audit of the combined financial statements of the Western Federal Power System (the System) as of and for the year ended September 30, 2015. During the audit, KPMG noted certain matters involving internal control and other operational matters that are presented in the management letter

  6. Audit Report: OAI-FS-16-10 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    10 Audit Report: OAI-FS-16-10 August 29, 2016 Southwestern Federal Power System's Fiscal Year 2015 Financial Statement Audit This report presents the results of the independent certified public accountants' audit of the Southwestern Federal Power System's (SWFPS) combined balance sheets, as of September 30, 2015 and 2014, and the related combined statements of changes in capitalization, revenues and expenses, and cash flows for the years then ended. To fulfill the Office of Inspector General's

  7. Audit Report: OAS-FS-12-10 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    2-10 Audit Report: OAS-FS-12-10 July 30, 2012 Southwestern Federal Power System's Fiscal Year 2010 Financial Statement Audit We contracted with the independent public accounting firm of KPMG, LLP (KPMG) to audit the combined balance sheets of the Southwestern Federal Power System (SWFPS) as of September 30, 2010 and 2009, and the related combined statements of revenues and expenses, changes in net Federal investment and cash flows for the years then ended. KPMG concluded that the combined

  8. Audit Report: OAS-FS-13-06 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    3-06 Audit Report: OAS-FS-13-06 November 29, 2012 Southwestern Federal Power System's Fiscal Year 2011 Financial Statement Audit We contracted with the independent public accounting firm of KPMG LLP to audit the combined balance sheets of the Southwestern Federal Power System (SWFPS) as of September 30, 2011 and 2010, and the related combined statements of changes in capitalization, revenues and expenses, and cash flows for the years then ended. KPMG concluded that the combined financial

  9. Audit Report: OAS-FS-14-09 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    9 Audit Report: OAS-FS-14-09 July 1, 2014 Southwestern Federal Power System's Fiscal Year 2013 Financial Statement Audit We contracted with the independent public accounting firm of KPMG LLP (KPMG) to conduct the audit of Southwestern Federal Power System's financial statements and report on applicable internal controls and compliance with laws and regulations. KPMG concluded that the combined financial statements present fairly, in all material respects, the respective financial position of

  10. Audit Report: OAS-FS-15-01 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    1 Audit Report: OAS-FS-15-01 November 17, 2014 Department of Energy's Fiscal Year 2014 Consolidated Financial Statements We engaged the independent public accounting firm of KPMG, LLP (KPMG) to perform the audit of the Department of Energy's (Department) Fiscal Year 2014 Consolidated Financial Statements. KPMG concluded that these consolidated financial statements are presented fairly, in all material respects, in conformity with United States generally accepted accounting principles and has

  11. Audit Report: OAS-FS-15-02 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    2 Audit Report: OAS-FS-15-02 November 19, 2014 Western Federal Power System's Fiscal Year 2013 Financial Statement Audit We contracted with the independent public accounting firm of KPMG, LLP (KPMG) to conduct the audit of the Western Federal Power System's (Western) combined balance sheets and report on Western's financial statements and reporting on applicable internal controls and compliance with laws and regulations. KPMG concluded that the combined financial statements present fairly, in

  12. Audit Report: OAS-FS-15-03 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    3 Audit Report: OAS-FS-15-03 November 24, 2014 Department of Energy's Nuclear Waste Fund's Fiscal Year 2014 Financial Statement Audit We contracted with the independent public accounting firm of KPMG, LLP (KPMG) to conduct the audit of the Department of Energy's Nuclear Waste Fund's balance sheets and related statements of net cost, changes in net position, and budgetary resources. KPMG concluded that the financial statements present fairly, in all material respects, the respective financial

  13. Audit Report: OAS-FS-15-04 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    4 Audit Report: OAS-FS-15-04 December 15, 2014 Management Letter on the Western Federal Power System's Fiscal Year 2013 Financial Statement Audit KPMG, LLP noted certain matters involving internal control and other operational matters during their audit of the Department of Energy's (Department) combined financial statements of the Western Federal Power System for fiscal year 2013. These matters are intended to improve the Department's internal controls or result in other operational

  14. Audit Report: OAS-FS-15-05 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    5 Audit Report: OAS-FS-15-05 December 17, 2014 Federal Energy Regulatory Commission's Fiscal Year 2014 Financial Statement Audit We contracted with the independent public accounting firm of KPMG, LLP (KPMG) to conduct the audit of the Federal Energy Regulatory Commission's (Commission) balance sheets and related statements of net cost, changes in net position, budgetary resources, and custodial activity. KPMG concluded that the financial statements present fairly, in all material respects, the

  15. Audit Report: OAS-FS-15-06 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    6 Audit Report: OAS-FS-15-06 January 5, 2015 Information Technology Management Letter on the Audit of the Department of Energy's Consolidated Balance Sheet for Fiscal Year 2014 During the audit, KPMG, LLP (KPMG), our contract auditors, noted certain matters involving internal control and other operational matters. These comments and recommendations are intended to improve internal control or result in other operating efficiencies. Additionally, KPMG identified a deficiency in internal control

  16. Audit Report: OAS-FS-15-07 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    7 Audit Report: OAS-FS-15-07 January 7, 2015 Management Letter on the Audit of the Department of Energy's Consolidated Financial Statements for Fiscal Year 2014 During the audit, KPMG, LLP (KPMG), our contract auditors, noted certain matters involving internal control and other operational matters. These comments and recommendations are intended to improve internal control or result in other operating efficiencies. Additionally, KPMG identified certain deficiencies in internal control that it

  17. Audit Report: OAS-FS-15-08 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    8 Audit Report: OAS-FS-15-08 January 7, 2015 Management Letter on the Federal Energy Regulatory Commission's Fiscal Year 2014 Financial Statement Audit During the audit, KPMG, LLP (KPMG), our contract auditors, noted certain matters involving internal control and other operational matters. These comments and recommendations are intended to improve internal control or result in other operating efficiencies. Additionally, KPMG identified certain deficiencies in internal control that it considered

  18. Audit Report: OAS-FS-15-10 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    0 Audit Report: OAS-FS-15-10 April 28, 2015 The Department of Energy's Improper Payment Reporting in the Fiscal Year 2014 Agency Financial Report The Department of Energy (Department) Office of Inspector General contracted with an independent certified public accounting firm, KPMG, LLP, (KPMG) to express an opinion on whether the Department met the Office of Management and Budget's criteria for compliance with the Improper Payments Elimination and Recovery Improvement Act (IPERIA). KPMG

  19. Audit Report: OAS-FS-15-11 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    1 Audit Report: OAS-FS-15-11 June 12, 2015 Southwestern Federal Power System's Fiscal Year 2014 Financial Statement Audit The Department of Energy Office of Inspector General contracted with the independent public accounting firm of KPMG, LLP, (KPMG) to express an opinion on Southwestern Federal Power System's financial statements and report on applicable internal controls and compliance with laws and regulations. KPMG concluded that the combined financial statements present fairly in accordance

  20. Audit Report: OAS-FS-15-12 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    2 Audit Report: OAS-FS-15-12 August 6, 2015 Western Federal Power System's Fiscal Year 2014 Financial Statement Audit The Department of Energy Office of Inspector General contracted with the independent public accounting firm of KPMG, LLP, (KPMG) to conduct an audit of the Western Federal Power System's (Western) combined balance sheets, as of September 30, 2014 and 2013, and the related combined statements of changes in capitalization, revenues and expenses, and cash flows for the years then

  1. Risk Assessment in the RI/FS process, and derivation of cleanup levels

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Assessment in the RI/FS process, and derivation of cleanup levels Jim Hansen Presentation to the RAP committee January 10, 2012 Risk Assessment - Basics * Baseline Risk Assessment evaluates the basis for action - is there risk that warrants action? * Risk assessment identifies contaminants of potential concern * Risk assessment provides a foundation for setting cleanup levels Risk Assessment - River Corridor * River Corridor Baseline Risk Assessment - Human Health - Ecological * Columbia River

  2. Audit Report: IG-FS-98-01 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    8-01 Audit Report: IG-FS-98-01 February 26, 1998 Report on "Audit of the Department of Energy's Consolidated Financial Statements for Fiscal Year 1997 The Office of Inspector General audited the Department's Consolidated Statement of Financial Position as of September 30, 1997, and the related Consolidated Statement of Operations and Changes in Net Position for the year then ended. In the opinion of the Office of Inspector General, these financial statements present fairly, in all material

  3. Audit Report: OAS-FS-10-02 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    2 Audit Report: OAS-FS-10-02 November 12, 2009 Report on "The Department of Energy's FiscalYear 2009 Consolidated Financial Statements" This is to inform you that the Department of Energy's (Department) Consolidated Financial Statements for Fiscal Year (FY) 2009 have received an unqualified opinion. Pursuant to requirements established by the Government Management Reform Act of 1994, the Office of Inspector General (OIG) engaged the independent public accounting firm of KPMG LLP (KPMG)

  4. Audit Report: OAS-FS-11-01 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    1 Audit Report: OAS-FS-11-01 November 12, 2010 Report on the Department of Energy's Fiscal Year2010 Consolidated Financial Statements This is to inform you that the audit of the Department of Energy's (Department) Fiscal Year (FY) 2010 Consolidated Financial Statements has resulted in an unqualified audit opinion. Pursuant to requirements established by the Government Management Reform Act of 1994, the Office of Inspector General (OIG) engaged the independent public accounting firm of KPMG LLP

  5. Audit Report: OAS-FS-11-05 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    5 Audit Report: OAS-FS-11-05 December 20, 2010 Management Letter on the Audit of the Department of Energy's Consolidated Financial Statements for Fiscal Year 2010 Attached is the subject letter prepared by KPMG LLP, our contract auditors. The letter contains 23 new findings (see letter, Exhibit A) and 4 repeat findings (see letter, Exhibit B) that were issued during the course of the Fiscal Year 2010 audit of the Department of Energy's (Department) Consolidated Financial Statements. Management

  6. Audit Report: OAS-FS-12-01 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    1 Audit Report: OAS-FS-12-01 November 15, 2011 The Federal Energy Regulatory Commission's Fiscal Year 2011 Financial Statement Audit KPMG concluded that the financial statements present fairly, in all material respects, the financial position of the Federal Energy Regulatory Commission as of September 30, 2011, and its net costs, changes in net position, budgetary resources, and custodial activity for the years then ended, in conformity with United States generally accepted accounting

  7. Audit Report: OAS-FS-12-03 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    3 Audit Report: OAS-FS-12-03 November 2, 2011 The Department of Energy's Nuclear Waste Fund's Fiscal Year 2011 Financial Statements The attached report presents the results of the independent certified public accountants' audit of the Department of Energy's Nuclear Waste Fund's (Fund) Fiscal Year 2011 balance sheet and the related statements of net cost, changes in net position, and budgetary resources.To fulfill the Office of Inspector General's audit responsibilities, we contracted with the

  8. Audit Report: OAS-FS-12-07 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    7 Audit Report: OAS-FS-12-07 March 15, 2012 Performance Audit of the Department of Energy's Improper Payment Reporting in the Fiscal Year 2011 Agency Financial Report To fulfill the Office of Inspector General's Audit Responsibilities we contracted with the independent public accounting firm of KPMG, LLP to express an opinion on whether the Department of Energy (Department) met the Office of Management and Budget's criteria for compliance with the Improper Payments Elimination and Recovery Act

  9. Audit Report: OAS-FS-13-11 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    1 Audit Report: OAS-FS-13-11 January 31, 2013 Department of Energy's Isotope Development and Production for Research and Applications Program's Fiscal Year 2010 Balance Sheet Audit The Office of Inspector General (OIG) engaged the independent public accounting firm of KPMG, LLP (KPMG) to audit the balance sheet of the United States Department of Energy's (Department) Isotope Development and Production for Research and Applications Program (the Program) (a component of the Department) as of

  10. Audit Report: OAS-FS-14-07 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    4-07 Audit Report: OAS-FS-14-07 March 20, 2014 Department of Energy's Uranium Enrichment Decontamination and Decommissioning Fund's Fiscal Year 2012 Financial Statement Audit We contracted with the independent public accounting firm of KPMG, LLP (KPMG) to conduct the audit of the Department of Energy's (Department) Uranium Enrichment Decontamination and Decommissioning Fund's (D&D Fund) Fiscal Year 2012 balance sheets and the related statements of net cost, changes in net position and

  11. FS Agre

    Office of Legacy Management (LM)

    BLM retains oil and gas administration responsibilities for any preexisting oil and gas leases. Institutional Controls DOE, through AEC, via contract AT (04-3) -711 , has been ...

  12. Audit Report: OAI-FS-16-03 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    3 Audit Report: OAI-FS-16-03 December 1, 2015 Department of Energy Nuclear Waste Fund's Fiscal Year 2015 Financial Statement Audit The attached report presents the results of the independent certified public accountants' audit on the balance sheets, as of September 30, 2015 and 2014, of the Department of Energy Nuclear Waste Fund (Fund) and the related statements of changes in net cost, changes in net position, and statements of budgetary resources for the years then ended. To fulfill Office of

  13. Audit Report: OAS-FS-11-06 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    1-06 Audit Report: OAS-FS-11-06 April 7, 2011 Department of Energy Isotope Program's Fiscal Year 2007 The attached report presents the results of the independent certified public accountants' audit of the United States (U.S.) Department of Energy Isotope Program's (the Program) Fiscal Year (FY) 2007 balance sheet and the related statements of net cost and changes in net position, and combined statement of budgetary resources for the year ended September 30, 2007 (hereinafter referred to as

  14. Audit Report: OAS-FS-14-08 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    8 Audit Report: OAS-FS-14-08 April 15, 2014 Performance Audit of the Department of Energy's Improper Payment Reporting in the Fiscal Year 2013 Agency Financial Report We contracted with the independent public accounting firm of KPMG LLP, to express an opinion on whether the Department of Energy (Department) met the U.S. Office of Management and Budget's criteria for compliance with the Improper Payments Elimination and Recovery Act of 2010 (IPERA). The objective of this audit was to complete an

  15. Audit Report: IG-FS-99-01 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    9-01 Audit Report: IG-FS-99-01 February 25, 1999 Audit Of The U.S Department Of Energy's Consolidated Financial Statements For Fiscal Year 1998 We have audited the accompanying consolidated balance sheets of the U.S. Department of Energy (Department) as of September 30, 1998 and 1997, and the related consolidated statements of net cost, changes in net position, budgetary resources, financing, and custodial activity for the years then ended. These financial statements are the responsibility of

  16. Smoothing single-crystalline SiC surfaces by reactive ion etching using pure NF{sub 3} and NF{sub 3}/Ar mixture gas plasmas

    SciTech Connect (OSTI)

    Tasaka, Akimasa; Kotaka, Yuki; Oda, Atsushi; Saito, Morihiro; Tojo, Tetsuro; Inaba, Minoru

    2014-09-01

    In pure NF{sub 3} plasma, the etching rates of four kinds of single-crystalline SiC wafer etched at NF{sub 3} pressure of 2 Pa were the highest and it decreased with an increase in NF{sub 3} pressure. On the other hand, they increased with an increase in radio frequency (RF) power and were the highest at RF power of 200 W. A smooth surface was obtained on the single-crystalline 4H-SiC after reactive ion etching at NF{sub 3}/Ar gas pressure of 2 Pa and addition of Ar to NF{sub 3} plasma increased the smoothness of SiC surface. Scanning electron microscopy observation revealed that the number of pillars decreased with an increase in the Ar-concentration in the NF{sub 3}/Ar mixture gas. The roughness factor (R{sub a}) values were decreased from 51.5 nm to 25.5 nm for the As-cut SiC, from 0.25 nm to 0.20 nm for the Epi-SiC, from 5.0 nm to 0.7 nm for the Si-face mirror-polished SiC, and from 0.20 nm to 0.16 nm for the C-face mirror-polished SiC by adding 60% Ar to the NF{sub 3} gas. Both the R{sub a} values of the Epi- and the C-face mirror-polished wafer surfaces etched using the NF{sub 3}/Ar (40:60) plasma were similar to that treated with mirror polishing, so-called the Catalyst-Referred Etching (CARE) method, with which the lowest roughness of surface was obtained among the chemical mirror polishing methods. Etching duration for smoothing the single-crystalline SiC surface using its treatment was one third of that with the CARE method.

  17. BFV activates the NF-kappaB pathway through its transactivator (BTas) to enhance viral transcription

    SciTech Connect (OSTI)

    Wang Jian; Tan Juan; Zhang Xihui; Guo Hongyan; Zhang Qicheng; Guo Tingting; Geng Yunqi; Qiao Wentao

    2010-05-10

    Multiple families of viruses have evolved sophisticated strategies to regulate nuclear factor-kappaB (NF-kappaB) signaling, which plays a pivotal role in diverse cellular events, including virus-host interactions. In this study, we report that bovine foamy virus (BFV) is able to activate the NF-kappaB pathway through the action of its transactivator, BTas. Both cellular IKKbeta and IkappaBalpha also participate in this activation. In addition, we demonstrate that BTas induces the processing of p100, which implies that BTas can activate NF-kappaB through a noncanonical pathway as well. Co-immunoprecipitation analysis shows that BTas interacts with IKK catalytic subunits (IKKalpha and IKKbeta), which may be responsible for regulation of IKK kinase activity and persistent NF-kappaB activation. Furthermore, our results indicate that the level of BTas-mediated LTR transcription correlates with the activity of cellular NF-kappaB. Together, this study suggests that BFV activates the NF-kappaB pathway through BTas to enhance viral transcription.

  18. Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NF{kappa}B

    SciTech Connect (OSTI)

    Eliseev, Roman A. . E-mail: Roman_Eliseev@urmc.rochester.edu; Schwarz, Edward M.; Zuscik, Michael J.; O'Keefe, Regis J.; Drissi, Hicham; Rosier, Randy N.

    2006-01-01

    The transcription factor NF{kappa}B is constitutively activated in various tumor cells where it promotes proliferation and represses apoptosis. The bone morphogenetic proteins (BMPs) delay cell proliferation and promote differentiation and apoptosis of bone cells through activation of Smad downstream effectors and via Smad-independent mechanisms. Thus, NF{kappa}B and BMP pathways play opposing roles in regulating osteoblastic cell fate. Here, we show that in osteosarcoma Saos2 osteoblasts, NF{kappa}B regulates the activity of the BMP/Smad signaling. Inhibition of NF{kappa}B by overexpression of mI{kappa}B leads to the induction of osteoblast differentiation. Saos2 cells overexpressing mI{kappa}B (Saos2-mI{kappa}B) exhibit higher expression of osteoblast phenotypic genes such as alkaline phosphatase, Runx2 and osteocalcin and are more responsive to BMP2 in comparison to wild-type cells (Saos2-wt) or empty vector infected controls (Saos2-EV). Furthermore, BMP-2 signaling and Smad phosphorylation are significantly increased in Saos2-mI{kappa}B cells in comparison to Saos2-EV cells. Inhibition of NF{kappa}B signaling in Saos2-mI{kappa}B cells is associated with decreased expression of the BMP signaling inhibitor Smad7. While gain of Smad7 function in Saos2-mI{kappa}B cells results in inhibition of BMP signaling, anti-sense knockdown of Smad7 in Saos2-EV cells leads to upregulation of BMP signaling. We therefore conclude that in osteosarcoma Saos2 cells, NF{kappa}B represses BMP/Smad signaling and BMP2-induced differentiation through Smad7.

  19. Observation of excited state charge transfer with fs/ps-CARS

    SciTech Connect (OSTI)

    Blom, Alex Jason

    2009-08-01

    Excited state charge transfer processes are studied using the fs/ps-CARS probe technique. This probe allows for multiplexed detection of Raman active vibrational modes. Systems studied include Michler's Ketone, Coumarin 120, 4-dimethylamino-4{prime}-nitrostilbene, and several others. The vibrational spectrum of the para di-substituted benzophenone Michler's Ketone in the first excited singlet state is studied for the first time. It is found that there are several vibrational modes indicative of structural changes of the excited molecule. A combined experimental and theoretical approach is used to study the simplest 7-amino-4-methylcoumarin, Coumarin 120. Vibrations observed in FTIR and spontaneous Raman spectra are assigned using density functional calculations and a continuum solvation model is used to predict how observed modes are affected upon inclusion of a solvent. The low frequency modes of the excited state charge transfer species 4-dimethylamino-4{prime}-nitrostilbene are studied in acetonitrile. Results are compared to previous work on this molecule in the fingerprint region. Finally, several partially completed projects and their implications are discussed. These include the two photon absorption of Coumarin 120, nanoconfinement in cyclodextrin cavities and sensitization of titania nanoparticles.

  20. Regulation Of Nf=kb And Mnsod In Low Dose Radiation Induced Adaptive Protection Of Mouse And Human Skin Cells

    SciTech Connect (OSTI)

    Jian Li

    2012-11-07

    A sampling of publications resulting from this grant is provided. One is on the subject of NF-κB-Mediated HER2 Overexpression in Radiation-Adaptive Resistance. Another is on NF-κB-mediated adaptive resistance to ionizing radiation.

  1. Highly resistive annealed low-temperature-grown InGaAs with sub-500 fs carrier lifetimes

    SciTech Connect (OSTI)

    Baker, C.; Gregory, I.S.; Tribe, W.R.; Bradley, I.V.; Evans, M.J.; Linfield, E.H.; Missous, M.

    2004-11-22

    We have optimized low-temperature-grown In{sub 0.3}Ga{sub 0.7}As for use in ultrafast photoconductive devices. Using low temperature ex situ annealing techniques, we have produced a photoconductive material that is highly resistive ({approx}10{sup 4} {omega} cm), has sub-500 fs carrier trapping lifetimes, and is matched to 1.06 {mu}m laser excitation.

  2. The Federal Energy Regulatory Commission's Fiscal Year 2012 Financial Statement Audit, OAS-FS-13-03

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Federal Energy Regulatory Commission's Fiscal Year 2012 Financial Statement Audit OAS-FS-13-03 November 2012 Department of Energy Washington, DC 20585 November 15, 2012 MEMORANDUM FOR THE CHAIRMAN, FEDERAL ENERGY REGULATORY COMMISSION FROM: Rickey R. Hass Deputy Inspector General for Audits and Inspections Office of Inspector General SUBJECT: INFORMATION: Federal Energy Regulatory Commission's Fiscal Year 2012 Financial Statement Audit The attached report presents the results of the independent

  3. Withaferin A disrupts ubiquitin-based NEMO reorganization induced by canonical NF-κB signaling

    SciTech Connect (OSTI)

    Jackson, Shawn S.; Oberley, Christopher; Hooper, Christopher P.; Grindle, Kreg; Wuerzberger-Davis, Shelly; Wolff, Jared; and others

    2015-02-01

    The NF-κB family of transcription factors regulates numerous cellular processes, including cell proliferation and survival responses. The constitutive activation of NF-κB has also emerged as an important oncogenic driver in many malignancies, such as activated B-cell like diffuse large B cell lymphoma, among others. In this study, we investigated the impact and mechanisms of action of Withaferin A, a naturally produced steroidal lactone, against both signal-inducible as well as constitutive NF-κB activities. We found that Withaferin A is a robust inhibitor of canonical and constitutive NF-κB activities, leading to apoptosis of certain lymphoma lines. In the canonical pathway induced by TNF, Withaferin A did not disrupt RIP1 polyubiquitination or NEMO–IKKβ interaction and was a poor direct IKKβ inhibitor, but prevented the formation of TNF-induced NEMO foci which colocalized with TNF ligand. While GFP-NEMO efficiently formed TNF-induced foci, a GFP-NEMO{sup Y308S} mutant that is defective in binding to polyubiquitin chains did not form foci. Our study reveals that Withaferin A is a novel type of IKK inhibitor which acts by disrupting NEMO reorganization into ubiquitin-based signaling structures in vivo. - Highlights: • Withaferin A, a NF-κB inhibitor, disrupts signaling induced NEMO localization, a novel point of inhibition. • NEMO can be localized to distinct signaling foci after treatment with TNF. • ABC-type DLCBL cells can be sensitized to apoptosis after treatment with Withaferin A.

  4. Piperlongumine selectively suppresses ABC-DLBCL through inhibition of NF-κB p65 subunit nuclear import

    SciTech Connect (OSTI)

    Niu, Mingshan; Shen, Yangling; Xu, Xiaoyu; Yao, Yao; Fu, Chunling; Yan, Zhiling; Wu, Qingyun; Cao, Jiang; Sang, Wei; Zeng, Lingyu; Li, Zhenyu; Liu, Xuejiao; and others

    2015-07-10

    Constitutive NF-κB activation is required for survival of activated B cell-like subtype of diffuse large B cell lymphoma (ABC-DLBCL). However, current NF-κB targeting strategies lack cancer cell specificity. Here, we identified a novel inhibitor, piperlongumine, features direct binding to NF-κB p65 subunit and suppression of p65 nuclear import. This was accompanied by NF-κB reporter activity suppression and NF-κB target gene downregulation. Moreover, mutation of Cys{sup 38} to Ser in p65 abolished this effect of piperlongumine on inhibition of p65 nuclear import. Furthermore, we show that piperlongumine selectively inhibited proliferation and induced apoptosis of ABC-DLBCL cells. Most notably, it has been reported that piperlongumine did not affect normal cells even at high doses and was nontoxic to animals. Hence, our current study provides new insight into piperlongumine's mechanism of action and novel approach to ABC-DLBCL target therapy. - Highlights: • Current NF-κB targeting strategies lack cancer cell specificity. • Piperlongumine inhibits NF-κB p65 subunit nuclear import via directly binding to p65. • Piperlongumine selectively inhibits proliferation of ABC-DLBCL cells. • This study provides a novel approach to ABC-DLBCL target therapy.

  5. Coal dust contiguity-induced changes in the concentration of TNF- and NF- B p65 on the ocular surface

    SciTech Connect (OSTI)

    Sun, Z.Y.; Hong, J.; Liu, Z.Y.; Jin, X.D.; Gu, C.H.

    2009-07-01

    To observe the influence of coal dust on ocular surface of coal miners and rabbits with coal dust contiguity on expression TNF- and NF- Bp65 and dry eye occurrence. Expression TNF- and NF- Bp65 in ocular surface were determined. Results showed tear production, BUT and lysozyme decreased for coal miners and rabbits with coal dust contiguity. Coal dust exposure was linked to development of xerophthalmia, and induced a higher expression of NF- B p65 and TNF- perhaps as a mechanism to resist coal dust ocular surface injury.

  6. BRAF activated non-coding RNA (BANCR) promoting gastric cancer cells proliferation via regulation of NF-κB1

    SciTech Connect (OSTI)

    Zhang, Zhi-Xin; Liu, Zhi-Qiang; Jiang, Biao; Lu, Xin-Yang; Ning, Xiao-Fei; Yuan, Chuan-Tao; Wang, Ai-Liang

    2015-09-18

    Background and objective: Long non-coding RNA, BANCR, has been demonstrated to contribute to the proliferation and migration of tumors. However, its molecular mechanism underlying gastric cancer is still unknown. In present study, we investigated whether BANCR was involved in the development of gastric cancer cells via regulation of NF-κB1. Methods: Human gastric cancer tissues were isolated as well as human gastric cell lines MGC803 and BGC823 were cultured to investigate the role of BANCR in gastric cancer. Results: BANCR expression was significantly up-regulated in gastric tumor tissues and gastric cell lines. Down-regulation of BANCR inhibited gastric cancer cell growth and promoted cell apoptosis, and it also contributed to a significant decrease of NF-κB1 (P50/105) expression and 3′UTR of NF-κB1 activity. Overexpression of NF-κB1 reversed the effect of BANCR on cancer cell growth and apoptosis. MiroRNA-9 (miR-9) targeted NF-κB1, and miR-9 inhibitor also reversed the effects of BANCR on gastric cancer cell growth and apoptosis. Conclusion: BANCR was highly expressed both in gastric tumor tissues and in cancer cells. NF-κB1 and miR-9 were involved in the role of BANCR in gastric cancer cell growth and apoptosis. - Highlights: • BANCR up-regulated in gastric cancer (GC) tissues and cell lines MGC803 and BGC823. • Down-regulation of BANCR inhibited GC cell growth and promoted cell apoptosis. • Down-regulation of BANCR contributed to decreased 3′UTR of NF-κB1 and its expression. • Overexpressed NF-κB1 reversed the effect of BANCR on GC cell growth. • miR-9 inhibitor reversed the effect of BANCR on cancer GC cell growth.

  7. Agreement Execution Process Study: CRADAs and NF-WFO Agreements and the Speed of Business

    SciTech Connect (OSTI)

    Harrer, Bruce J.; Cejka, Cheryl L.; Macklin, Richard; Miksovic, Ann

    2011-02-01

    This report summarizes the findings of a study on the execution of Cooperative Research and Development Agreements (CRADAs) and Non-Federal Work for Others (NF-WFO) agreements across the U.S. Department of Energy (DOE) laboratory complex. The study provides quantitiative estimates of times required to negotiate and execute these agreements across the DOE complex. It identifies factors impacting on cycle times and describes best practicies used at various laboratories and site offices that reduce cycle times.

  8. XEDAR activates the non-canonical NF-κB pathway

    SciTech Connect (OSTI)

    Verhelst, Kelly; Gardam, Sandra; Borghi, Alice; Kreike, Marja; Carpentier, Isabelle; Beyaert, Rudi

    2015-09-18

    Members of the tumor necrosis factor receptor (TNFR) superfamily are involved in a number of physiological and pathological responses by activating a wide variety of intracellular signaling pathways. The X-linked ectodermal dysplasia receptor (XEDAR; also known as EDA2R or TNFRSF27) is a member of the TNFR superfamily that is highly expressed in ectodermal derivatives during embryonic development and binds to ectodysplasin-A2 (EDA-A2), a member of the TNF family that is encoded by the anhidrotic ectodermal dysplasia (EDA) gene. Although XEDAR was first described in the year 2000, its function and molecular mechanism of action is still largely unclear. XEDAR has been reported to activate canonical nuclear factor κB (NF-κB) signaling and mitogen-activated protein (MAP) kinases. Here we report that XEDAR is also able to trigger the non-canonical NF-κB pathway, characterized by the processing of p100 (NF-κB2) into p52, followed by nuclear translocation of p52 and RelB. We provide evidence that XEDAR-induced p100 processing relies on the binding of XEDAR to TRAF3 and TRAF6, and requires the kinase activity of NIK and IKKα. We also show that XEDAR stimulation results in NIK accumulation and that p100 processing is negatively regulated by TRAF3, cIAP1 and A20. - Highlights: • XEDAR activates the non-canonical NF-κB pathway. • XEDAR-induced processing of p100 depends on XEDAR interaction with TRAF3 and TRAF6. • XEDAR-induced processing of p100 depends on NIK and IKKα activity. • Overexpression of XEDAR leads to NIK accumulation. • XEDAR-induced processing of p100 is negatively regulated by TRAF3 cIAP1 and A20.

  9. Characterization of the Kinetics of NF3-Fluorination of NpO2

    SciTech Connect (OSTI)

    Casella, Andrew M.; Scheele, Randall D.; McNamara, Bruce K.

    2015-12-23

    The exploitation of selected actinide and fission product fluoride volatilities has long been considered as a potentially attractive compact method for recycling used nuclear fuels to avoid generating the large volumes of radioactive waste arising from aqueous reprocessing [1-7]. The most developed process uses the aggressive and hazardous fluorinating agents hydrogen fluoride (HF) and/or molecular fluorine (F2) at high temperatures to volatilize the greatest fraction of the used nuclear fuel into a single gas stream. The volatilized fluorides are subsequently separated using a series of fractionation and condensation columns to recover the valuable fuel constituents and fission products. In pursuit of a safer and less complicated approach, we investigated an alternative fluoride volatility-based process using the less hazardous fluorinating agent nitrogen trifluoride (NF3) and leveraging its less aggressive nature to selectively evolve fission product and actinide fluorides from the solid phase based on their reaction temperatures into a single recycle stream [8-15]. In this approach, successive isothermal treatments using NF3 will first evolve the more thermally susceptible used nuclear fuel constituents leaving the other constituents in the residual solids until subsequent isothermal temperature treatments cause these others to volatilize. During investigation of this process, individual neat used fuel components were treated with isothermal NF3 in an attempt to characterize the kinetics of each fluorination reaction to provide input into the design of a new volatile fluoride separations approach. In these directed investigations, complex behavior was observed between NF3 and certain solid reactants such as the actinide oxides of uranium, plutonium, and neptunium. Given the similar thermal reaction susceptibilities of neptunium oxide (NpO2) and uranium dioxide (UO2) and the importance of Np and U, we initially focused our efforts on determining the reaction

  10. Temperature measurements in metalized propellant combustion using hybrid fs/ps coherent anti-Stokes Raman scattering

    DOE PAGES-Beta [OSTI]

    Kearney, Sean P.; Guildenbecher, Daniel R.

    2016-06-20

    We apply ultrafast pure-rotational coherent anti-Stokes Raman scattering (CARS) for temperature and relative oxygen concentration measurements in the plume emanating from a burning, aluminized ammonium-perchlorate propellant strand. Combustion of these metal-based propellants is a particularly hostile environment for laser-based diagnostics, with intense background luminosity and scattering from hot metal particles as large as several hundred micrometers in diameter. CARS spectra that were previously obtained using nanosecond pulsed lasers in an aluminum-particle-seeded flame are examined and are determined to be severely impacted by nonresonant background, presumably as a result of the plasma formed by particulate-enhanced laser-induced breakdown. Introduction of femtosecond/picosecond (fs/ps)more » laser pulses improves CARS detection by providing time-gated elimination of strong nonresonant background interference. Single-laser-shot fs/ps CARS spectra were acquired from the burning propellant plume, with picosecond probe-pulse delays of 0 and 16 ps from the femtosecond pump and Stokes pulses. At zero delay, nonresonant background overwhelms the Raman-resonant spectroscopic features. Time-delayed probing results in the acquisition of background-free spectra that were successfully fit for temperature and relative oxygen content. Temperature probability densities and temperature/oxygen correlations were constructed from ensembles of several thousand single-laser-shot measurements with the CARS measurement volume positioned within 3 mm or less of the burning propellant surface. Lastly, the results show that ultrafast CARS is a potentially enabling technology for probing harsh, particle-laden flame environments.« less

  11. Nickel differentially regulates NFAT and NF-{kappa}B activation in T cell signaling

    SciTech Connect (OSTI)

    Saito, Rumiko; Hirakawa, Satoshi; Ohara, Hiroshi; Yasuda, Makoto; Yamazaki, Tomomi; Nishii, Shigeaki; Aiba, Setsuya

    2011-08-01

    Nickel is a potent hapten that induces contact hypersensitivity in human skin. While nickel induces the maturation of dendritic cells via NF-{kappa}B and p38 MAPK activation, it also exerts immunosuppressive effects on T cells through an unknown mechanism. To elucidate the molecular mechanisms of its effects on T cells, we examined the effects of NiCl{sub 2} on mRNA expression in human CD3+ T cells stimulated with CD3 and CD28 antibodies. Using a DNA microarray and Gene Ontology, we identified 70 up-regulated (including IL-1{beta}, IL-6 and IL-8) and 61 down-regulated (including IL-2, IL-4, IL-10 and IFN-{gamma}) immune responsive genes in NiCl{sub 2}-treated T cells. The DNA microarray results were verified using real-time PCR and a Bio-Plex{sup TM} suspension protein array. Suppression of IL-2 and IFN-{gamma} gene transcription by NiCl{sub 2} was also confirmed using Jurkat T cells transfected with IL-2 or IFN-{gamma} luciferase reporter genes. To explore the NiCl{sub 2}-regulated signaling pathway, we examined the binding activity of nuclear proteins to NFAT, AP-1, and NF-{kappa}B consensus sequences. NiCl{sub 2} significantly and dose-dependently suppressed NFAT- and AP-1-binding activity, but augmented NF-{kappa}B-binding activity. Moreover, NiCl{sub 2} decreased nuclear NFAT expression in stimulated T cells. Using Jurkat T cells stimulated with PMA/ionomycin, we demonstrated that NiCl{sub 2} significantly suppressed stimulation-evoked cytosolic Ca{sup 2+} increases, suggesting that NiCl{sub 2} regulates NFAT signals by acting as a blocker of Ca{sup 2+} release-activated Ca{sup 2+} (CRAC) channels. These data showed that NiCl{sub 2} decreases NFAT and increases NF-{kappa}B signaling in T cells. These results shed light on the effects of nickel on the molecular regulation of T cell signaling. - Graphical Abstract: Nickel suppresses stimulation-evoked cytosolic Ca{sup 2+} increase, which results in the suppression of NFAT signals. On the other hand, Ni rather

  12. XIAP Induces NF-kB Activation via the BIR1/TAB1 Interaction and BIR1 Dimerization

    SciTech Connect (OSTI)

    Lu,M.; Lin, S.; Huang, Y.; Kang, Y.; Rich, R.; Lo, Y.; Myszka, D.; Han, J.; Wu, H.

    2007-01-01

    In addition to caspase inhibition, X-linked inhibitor of apoptosis (XIAP) induces NF-{kappa}B and MAP kinase activation during TGF-b and BMP receptor signaling and upon overexpression. Here we show that the BIR1 domain of XIAP, which has no previously ascribed function, directly interacts with TAB1 to induce NF-{kappa}B activation. TAB1 is an upstream adaptor for the activation of the kinase TAK1, which in turn couples to the NF-{kappa}B pathway. We report the crystal structures of BIR1, TAB1, and the BIR1/TAB1 complex. The BIR1/TAB1 structure reveals a striking butterfly-shaped dimer and the detailed interaction between BIR1 and TAB1. Structure-based mutagenesis and knockdown of TAB1 show unambiguously that the BIR1/TAB1 interaction is crucial for XIAP-induced TAK1 and NF-{kappa}B activation. We show that although not interacting with BIR1, Smac, the antagonist for caspase inhibition by XIAP, also inhibits the XIAP/TAB1 interaction. Disruption of BIR1 dimerization abolishes XIAP-mediated NF-{kappa}B activation, implicating a proximity-induced mechanism for TAK1 activation.

  13. Constitutive NF-?B activation and tumor-growth promotion by Romo1-mediated reactive oxygen species production

    SciTech Connect (OSTI)

    Chung, Jin Sil; Lee, Sora; Yoo, Young Do

    2014-08-08

    Highlights: Romo1 expression is required for constitutive nuclear DNA-binding activity of NF-?B. Romo1 depletion suppresses tumor growth in vivo. Romo1 presents a potential therapeutic target for diseases. - Abstract: Deregulation of nuclear factor-?B (NF-?B) and related pathways contribute to tumor cell proliferation and invasion. Mechanisms for constitutive NF-?B activation are not fully explained; however, the underlying defects appear to generate and maintain pro-oxidative conditions. In hepatocellular carcinoma (HCC) tissues, up-regulation of reactive oxygen species modulator 1 (Romo1) correlates positively with tumor size. In the present study, we showed that Romo1 expression is required to maintain constitutive nuclear DNA-binding activity of NF-?B and transcriptional activity through constitutive I?B? phosphorylation. Overexpression of Romo1 promoted p65 nuclear translocation and DNA-binding activity. We also show that Romo1 depletion suppressed anchorage-independent colony formation by HCC cells and suppressed tumor growth in vivo. Based on these findings, Romo1 may be a principal regulatory factor in the maintenance of constitutive NF-?B activation in tumor cells. In the interest of anti-proliferative treatments for cancer, Romo1 may also present a productive target for drug development.

  14. FY13 Summary Report on the Augmentation of the Spent Fuel Composition Dataset for Nuclear Forensics: SFCOMPO/NF

    SciTech Connect (OSTI)

    Brady Raap, Michaele C.; Lyons, Jennifer A.; Collins, Brian A.; Livingston, James V.

    2014-03-31

    This report documents the FY13 efforts to enhance a dataset of spent nuclear fuel isotopic composition data for use in developing intrinsic signatures for nuclear forensics. A review and collection of data from the open literature was performed in FY10. In FY11, the Spent Fuel COMPOsition (SFCOMPO) excel-based dataset for nuclear forensics (NF), SFCOMPO/NF was established and measured data for graphite production reactors, Boiling Water Reactors (BWRs) and Pressurized Water Reactors (PWRs) were added to the dataset and expanded to include a consistent set of data simulated by calculations. A test was performed to determine whether the SFCOMPO/NF dataset will be useful for the analysis and identification of reactor types from isotopic ratios observed in interdicted samples.

  15. Formerly Used Sites Remedial Action Program (FUSRAP) W. R. Grace Feasibility Study (FS) Alternative Development Process Challenges And Successes

    SciTech Connect (OSTI)

    Fatherly, N.; O'Neill, M.; Glemza, A.

    2008-07-01

    Monazite sand processing was conducted at the W. R. Grace Curtis Bay Facility (Baltimore, Maryland) in the mid 1950's under contract to the Atomic Energy Commission (AEC), for the extraction of source material in the form of thorium, as well as rare earth elements. The processing was conducted in the southwest quadrant of a five-story building (Building 23) in the active manufacturing portion of the facility. Building components and equipment in the southwest quadrant of Building 23 exhibit residual radiological activity remaining from the monazite sand processing. Waste materials from the processing operations (termed gangue) were disposed in the non-manufacturing portion of the facility, in the area referred to the Radioactive Waste Disposal Area (RWDA). Approximately 19,880 cubic meters (m{sup 3}) of radioactive gangue was buried within the RWDA. Waste was believed to be buried at various depths up to 2.7 meters (m), and possibly as deep as 7.6 m. The RI and a supplemental investigation have been completed for the RWDA and adjacent boundary areas. A Feasibility Study (FS) to address residual radioactivity in soils at the RWDA is in the process of being finalized. The chemical-specific Applicable, Relevant, and Appropriate Requirement (ARAR) was selected for the FUSRAP contaminants, and Remedial Goals (RGs) were calculated for the cleanup. The RGs were developed based upon guidance provided in the selected ARAR, 10 Code of Federal Regulations (CFR) 40, Appendix A, Criterion 6(6). This standard is designed to provide an acceptable level of protection to the average member of a critical group who may be exposed to radium in soil for a given scenario. Scenarios, critical group members, and RGs were established in consultation with stakeholders. Dose assessment calculations were performed in accordance with the ARAR to establish derived concentration guideline levels (DCGLs) for each radionuclide in the 232-Thorium ({sup 232}Th) and 238-Uranium ({sup 238}U) chain for

  16. Hybrid fs/ps rotational CARS temperature and oxygen measurements in the product gases of canonical flat flames

    SciTech Connect (OSTI)

    Kearney, Sean Patrick

    2014-12-31

    A hybrid fs/ps pure-rotational coherent anti-Stokes Raman scattering (CARS) scheme is systematically evaluated over a wide range of flame conditions in the product gases of two canonical flat-flame burners. Near-transform-limited, broadband femtosecond pump and Stokes pulses impulsively prepare a rotational Raman coherence, which is later probed using a high-energy, frequency-narrow picosecond beam generated by the second-harmonic bandwidth compression scheme that has recently been demonstrated for rotational CARS generation in H2/air flat flames. The measured spectra are free of collision effects and nonresonant background and can be obtained on a single-shot basis at 1 kHz. The technique is evaluated for temperature/oxygen measurements in near-adiabatic H2/air flames stabilized on the Hencken burner for equivalence ratios of φ = 0.20–1.20. Thermometry is demonstrated in hydrocarbon/air products for φ = 0.75–3.14 in premixed C2H4/air flat flames on the McKenna burner. Reliable spectral fitting is demonstrated for both shot-averaged and single-laser-shot data using a simple phenomenological model. Measurement accuracy is benchmarked by comparison to adiabatic-equilibrium calculations for the H2/air flames, and by comparison with nanosecond CARS measurements for the C2H4/air flames. Quantitative accuracy comparable to nanosecond rotational CARS measurements is observed, while the observed precision in both the temperature and oxygen data is extraordinarily high, exceeding nanosecond CARS, and on par with the best published thermometric precision by femtosecond vibrational CARS in flames, and rotational femtosecond CARS at low temperature. Threshold levels of signal-to-noise ratio to achieve 1–2% precision in temperature and O2/N2 ratio are identified. Our results show that pure-rotational fs/ps CARS is a robust and quantitative tool when applied across a wide

  17. Hybrid fs/ps rotational CARS temperature and oxygen measurements in the product gases of canonical flat flames

    DOE PAGES-Beta [OSTI]

    Kearney, Sean Patrick

    2014-12-31

    A hybrid fs/ps pure-rotational coherent anti-Stokes Raman scattering (CARS) scheme is systematically evaluated over a wide range of flame conditions in the product gases of two canonical flat-flame burners. Near-transform-limited, broadband femtosecond pump and Stokes pulses impulsively prepare a rotational Raman coherence, which is later probed using a high-energy, frequency-narrow picosecond beam generated by the second-harmonic bandwidth compression scheme that has recently been demonstrated for rotational CARS generation in H2/air flat flames. The measured spectra are free of collision effects and nonresonant background and can be obtained on a single-shot basis at 1 kHz. The technique is evaluated for temperature/oxygenmore » measurements in near-adiabatic H2/air flames stabilized on the Hencken burner for equivalence ratios of φ = 0.20–1.20. Thermometry is demonstrated in hydrocarbon/air products for φ = 0.75–3.14 in premixed C2H4/air flat flames on the McKenna burner. Reliable spectral fitting is demonstrated for both shot-averaged and single-laser-shot data using a simple phenomenological model. Measurement accuracy is benchmarked by comparison to adiabatic-equilibrium calculations for the H2/air flames, and by comparison with nanosecond CARS measurements for the C2H4/air flames. Quantitative accuracy comparable to nanosecond rotational CARS measurements is observed, while the observed precision in both the temperature and oxygen data is extraordinarily high, exceeding nanosecond CARS, and on par with the best published thermometric precision by femtosecond vibrational CARS in flames, and rotational femtosecond CARS at low temperature. Threshold levels of signal-to-noise ratio to achieve 1–2% precision in temperature and O2/N2 ratio are identified. Our results show that pure-rotational fs/ps CARS is a robust and quantitative tool when applied across a wide range of flame conditions spanning lean H2/air combustion to fuel-rich sooting hydrocarbon

  18. Intranuclear interactomic inhibition of NF-κB suppresses LPS-induced severe sepsis

    SciTech Connect (OSTI)

    Park, Sung-Dong; Cheon, So Yeong; Park, Tae-Yoon; Shin, Bo-Young; Oh, Hyunju; Ghosh, Sankar; Koo, Bon-Nyeo; Lee, Sang-Kyou

    2015-08-28

    Suppression of nuclear factor-κB (NF-κB) activation, which is best known as a major regulator of innate and adaptive immune responses, is a potent strategy for the treatment of endotoxic sepsis. To inhibit NF-κB functions, we designed the intra-nuclear transducible form of transcription modulation domain (TMD) of RelA (p65), called nt-p65-TMD, which can be delivered effectively into the nucleus without influencing the cell viability, and work as interactomic inhibitors via disruption of the endogenous p65-mediated transcription complex. nt-p65-TMD effectively inhibited the secretion of pro-inflammatory cytokines, including TNF-α, IL-1β, or IL-6 from BV2 microglia cells stimulated by lipopolysaccharide (LPS). nt-p65-TMD did not inhibit tyrosine phosphorylation of signaling mediators such as ZAP-70, p38, JNK, or ERK involved in T cell activation, but was capable of suppressing the transcriptional activity of NF-κB without the functional effect on that of NFAT upon T-cell receptor (TCR) stimulation. The transduced nt-p65-TMD in T cell did not affect the expression of CD69, however significantly inhibited the secretion of T cell-specific cytokines such as IL-2, IFN-γ, IL-4, IL-17A, or IL-10. Systemic administration of nt-p65-TMD showed a significant therapeutic effect on LPS-induced sepsis model by inhibiting pro-inflammatory cytokines secretion. Therefore, nt-p65-TMD can be a novel therapeutics for the treatment of various inflammatory diseases, including sepsis, where a transcription factor has a key role in pathogenesis, and further allows us to discover new functions of p65 under normal physiological condition without genetic alteration. - Highlights: • The nt-p65-TMD is intra-nuclear interactomic inhibitor of endogenous p65. • The nt-p65-TMD effectively inhibited the secretion of pro-inflammatory cytokines. • The excellent therapeutic potential of nt-p65-TMD was confirmed in sepsis model.

  19. Regenerative amplification of femtosecond pulses: Design and construction of a sub-100fs, {mu}J laser system

    SciTech Connect (OSTI)

    Schumacher, A.B. |

    1996-10-01

    Femtosecond lasers are a powerful tool for a wealth of applications in physics, chemistry and biology. In most cases, however, their use is fundamentally restricted to a rather narrow spectral range. This thesis deals with the construction and characterization of a femtosecond light source for spectroscopic applications which overcomes that restriction. It is demonstrated how the output of a continuously pumped Ti:sapphire femtosecond oscillator is amplified to the {mu}J level, while the pulse duration remains below 100fs. A combination of continuous pumping, acousto-optic switching and Ti:Al{sub 2}O{sub 3} as a gain medium allows amplification at high repetition rates. By focusing the high energy pulses into a sapphire crystal, a broad-band continuum can be generated, extended in wavelengths over several hundred nanometers. To accomplish amplification of three orders of magnitude while maintaining the pulse length, a regenerative multipass amplifier system was built. The thesis describes theoretical design, realization and characterization of the system. Theoretical calculations and preliminary measurements were carried out and allow a critical evaluation of the final performance.

  20. Regenerative Amplification of Femtosecond Pulses: Design andConstruction of a sub-100fs, muon J Laser System

    SciTech Connect (OSTI)

    Schumacher, Andreas B.

    1996-10-01

    Femtosecond lasers are a powerful tool for a wealth of applications in physics, chemistry and biology. In most cases, however, their use is fundamentally restricted to a rather narrow spectral range. This thesis deals with the construction and characterization of a femtosecond light source for spectroscopic applications which overcomes that restriction. It is demonstrated how the output of a continuously pumped Ti:sapphire femtosecond oscillator is amplified to the {mu}J level,while the pulse duration remains below 100 fs. A combination of continuous pumping, acousto-optic switching and Ti:Al{sub 2}O{sub 3} as a gain medium allows amplification at high repetition rates. By focusing the high energy pulses into a sapphire crystal, a broad-band continuum can be generated, extended in wavelengths over several hundred nanometers. To accomplish amplification of three orders of magnitude while maintaining the pulse length, a regenerative multipass amplifier system was built. The thesis describes theoretical design, realization and characterization of the system. Theoretical calculations and preliminary measurements were carried out and allow a critical evaluation of the final performance.

  1. Absorption of a single 500 fs laser pulse at the surface of fused silica: Energy balance and ablation efficiency

    SciTech Connect (OSTI)

    Varkentina, N.; Sanner, N.; Lebugle, M.; Sentis, M.; Utéza, O.

    2013-11-07

    Ablation of fused silica by a single femtosecond laser pulse of 500 fs pulse duration is investigated from the perspective of efficiency of incident photons to remove matter. We measure the reflected and transmitted fractions of the incident pulse energy as a function of fluence, allowing us to recover the evolution of absorption at the material surface. At the ablation threshold fluence, 25% of incident energy is absorbed. At high fluences, this ratio saturates around 70% due to the appearance of a self-triggered plasma mirror (or shielding) effect. By using the energy balance retrieved experimentally and measurements of the ablated volume, we show that the amount of absorbed energy is far above the bonding energy of fused silica at rest and also above the energy barrier to ablate the material under non-equilibrium thermodynamic conditions. Our results emphasize the crucial role of transient plasma properties during the laser pulse and suggest that the major part of the absorbed energy has been used to heat the plasma formed at the surface of the material. A fluence range yielding an efficient and high quality ablation is also defined, which makes the results relevant for femtosecond micromachining processes.

  2. 3D calculation of Tucson-Melbourne 3NF effect in triton binding energy

    SciTech Connect (OSTI)

    Hadizadeh, M. R.; Tomio, L.; Bayegan, S.

    2010-08-04

    As an application of the new realistic three-dimensional (3D) formalism reported recently for three-nucleon (3N) bound states, an attempt is made to study the effect of three-nucleon forces (3NFs) in triton binding energy in a non partial wave (PW) approach. The spin-isospin dependent 3N Faddeev integral equations with the inclusion of 3NFs, which are formulated as function of vector Jacobi momenta, specifically the magnitudes of the momenta and the angle between them, are solved with Bonn-B and Tucson-Melbourne NN and 3N forces in operator forms which can be incorporated in our 3D formalism. The comparison with numerical results in both, novel 3D and standard PW schemes, shows that non PW calculations avoid the very involved angular momentum algebra occurring for the permutations and transformations and it is more efficient and less cumbersome for considering the 3NF.

  3. Management Letter on the Department of Energy's Isotope Development and Production for Research and Applications Program's Fiscal Year 2009 Balance Sheet Audit, OAS-FS-12-09

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy's Isotope Development and Production for Research and Applications Program's Fiscal Year 2009 Balance Sheet Audit OAS-FS-12-09 June 2012 January 30, 2012 Mr. Gregory Friedman, Inspector General Dr. Jehanne Gillo, Director, Facilities and Project Management Division, Office of Nuclear Physics U.S. Department of Energy Washington, DC 20585 Dear Mr. Friedman and Dr. Gillo: We have audited the balance sheet of the United States Department of Energy's (Department or DOE) Isotope

  4. Audit Report - Department of Energy's Isotope Development and Production for Research and Applications Program's Fiscal Year 2010 Balance Sheet Audit, OAS-FS-13-09

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Audits and Inspections Audit Report Department of Energy's Isotope Development and Production for Research and Applications Program's Fiscal Year 2010 Balance Sheet Audit OAS-FS-13-09 January 2013 MEMORANDUM FOR THE DIRECTOR, OFFICE OF SCIENCE FROM: Daniel M. Weeber Assistant Inspector General for Office of Inspector General SUBJECT: INFORMATION Production for Research and Applications Program's Fiscal Year 2010 Balance Sheet Audit The attached report presents the results of the independent

  5. PSMB4 promotes multiple myeloma cell growth by activating NF-κB-miR-21 signaling

    SciTech Connect (OSTI)

    Zheng, Peihao; Guo, Honggang; Li, Guangchao; Han, Siqi; Luo, Fei; Liu, Yi

    2015-03-06

    Proteasomal subunit PSMB4, was recently identified as potential cancer driver genes in several tumors. However, the regulatory mechanism of PSMB4 on carcinogenesis process remains unclear. In this study, we investigated the expression and roles of PSMB4 in multiple myeloma (MM). We found a significant up-regulation of PSMB4 in MM plasma and cell lines. Ectopic overexpression of PSMB4 promoted cell growth and colony forming ability of MM cells, whereas inhibition of PSMB4 led to a decrease of such events. Furthermore, our results demonstrated the up-regulation of miR-21 and a positive correlation between the levels of miR-21 and PSMB4 in MM. Re-expression of miR-21 markedly rescued PSMB4 knockdown-mediated suppression of cell proliferation and clone-formation. Additionally, while enforced expression of PSMB4 profoundly increased NF-κB activity and the level of miR-21, PSMB4 knockdown or NF-κB inhibition suppressed miR-21 expression in MM cells. Taken together, our results demonstrated that PSMB4 regulated MM cell growth in part by activating NF-κB-miR-21 signaling, which may represent promising targets for novel specific therapies. - Highlights: • First reported upregulation of PSMB4 in MM plasma and cell lines. • PSMB4 promoted MM cell growth and colony forming ability. • Further found miR-21 was up-regulated by PSMB4 in MM plasma and cell lines. • PSMB4-induced miR-21 expression was modulated by NF-κB. • PSMB4-NF-κB-miR-21 axis may be potential therapeutic targets of MM.

  6. 27-Oxygenated cholesterol induces expression of CXCL8 in macrophages via NF-κB and CD88

    SciTech Connect (OSTI)

    Kim, Sun-Mi; Lee, Chung Won; Kim, Bo-Young; Jung, Young-Suk; Eo, Seong-Kug; Park, Young Chul; Kim, Koanhoi

    2015-08-07

    We attempted to determine the effects of a milieu rich in cholesterol molecules on expression of chemokine CXCL8. A high-cholesterol diet led to an increased transcription of the IL-8 gene in the arteries and elevated levels of CXCL8 in sera of ApoE{sup −/−} mice, compared with those of wild-type C57BL/6 mice. Treatment of THP-1 monocyte/macrophage cells with 27-hydroxycholesterol (27OHChol) resulted in transcription of the IL-8 gene and increased secretion of its corresponding gene product whereas cholesterol did not induce expression of CXCL8 in THP-1 cells. 27OHChol-induced transcription of the IL-8 gene was blocked by cycloheximide, but not by polymyxin B. Treatment of THP-1 cells with 27OHChol caused translocation of p65 NF-κB subunit into the nucleus and up-regulation of CD88. Inhibition of NF-κB and CD88 using SN50 and W-54011, respectively, resulted in reduced transcription of the IL-8 gene and attenuated secretion of CXCL8 induced by 27OHChol. We propose that oxidatively modified cholesterol like 27OHChol, rather than cholesterol, is responsible for sustained expression of CXCL8 in monocytes/macrophages in atherosclerotic arteries. - Highlights: • Consumption of a high-cholesterol diet leads to increased CXCL8 expression in ApoE{sup −/−} mice. • 27OHChol, but not cholesterol, up-regulates expression of CXCL8 in macrophages. • 27OHChol enhances nuclear translocation of NF-κB and expression of CD88 in macrophages. • Inhibition of NF-κB or CD88 results in decreased CXCL8 expression induced by 27OHChol. • 27OHChol up-regulates CXCL8 expression via NF-κB and CD88 in macrophages.

  7. miR-339-5p inhibits alcohol-induced brain inflammation through regulating NF-κB pathway

    SciTech Connect (OSTI)

    Zhang, Yu; Wei, Guangkuan; Di, Zhiyong; Zhao, Qingjie

    2014-09-26

    Graphical abstract: - Highlights: • Alcohol upregulates miR-339-5p expression. • miR-339-5p inhibits the NF-kB pathway. • miR-339-5p interacts with and blocks activity of IKK-beat and IKK-epsilon. • miR-339-5p modulates IL-1β, IL-6 and TNF-α. - Abstract: Alcohol-induced neuroinflammation is mediated by the innate immunesystem. Pro-inflammatory responses to alcohol are modulated by miRNAs. The miRNA miR-339-5p has previously been found to be upregulated in alcohol-induced neuroinflammation. However, little has been elucidated on the regulatory functions of this miRNA in alcohol-induced neuroinflammation. We investigated the function of miR-339-5p in alcohol exposed brain tissue and isolated microglial cells using ex vivo and in vitro techniques. Our results show that alcohol induces transcription of miR 339-5p, IL-6, IL-1β and TNF-α in mouse brain tissue and isolated microglial cells by activating NF-κB. Alcohol activation of NF-κB allows for nuclear translocation of the NF-κB subunit p65 and expression of pro-inflammatory mediators. miR-339-5p inhibited expression of these pro-inflammatory factors through the NF-κB pathway by abolishing IKK-β and IKK-ε activity.

  8. Interleukin 6 promotes endometrial cancer growth through an autocrine feedback loop involving ERKNF-?B signaling pathway

    SciTech Connect (OSTI)

    Che, Qi; Liu, Bin-Ya; Wang, Fang-Yuan; He, Yin-Yan; Lu, Wen; Liao, Yun; Gu, Wei; Wan, Xiao-Ping

    2014-03-28

    Highlights: IL-6 could promote endometrial cancer cells proliferation. IL-6 promotes its own production through an autocrine feedback loop. ERK and NF-?B pathway inhibitors inhibit IL-6 production and tumor growth. IL-6 secretion relies on the activation of ERKNF-?B pathway axis. An orthotopic nude endometrial carcinoma model confirms the effect of IL-6. - Abstract: Interleukin (IL)-6 as an inflammation factor, has been proved to promote cancer proliferation in several human cancers. However, its role in endometrial cancer has not been studied clearly. Previously, we demonstrated that IL-6 promoted endometrial cancer progression through local estrogen biosynthesis. In this study, we proved that IL-6 could directly stimulate endometrial cancer cells proliferation and an autocrine feedback loop increased its production even after the withdrawal of IL-6 from the medium. Next, we analyzed the mechanism underlying IL-6 production in the feedback loop and found that its production and IL-6-stimulated cell proliferation were effectively blocked by pharmacologic inhibitors of nuclear factor-kappa B (NF-?B) and extra-cellular signal-regulated kinase (ERK). Importantly, activation of ERK was upstream of the NF-?B pathways, revealing the hierarchy of this event. Finally, we used an orthotopic nude endometrial carcinoma model to confirm the effects of IL-6 on the tumor progression. Taken together, these data indicate that IL-6 promotes endometrial carcinoma growth through an expanded autocrine regulatory loop and implicate the ERKNF-?B pathway as a critical mediator of IL-6 production, implying IL-6 to be an important therapeutic target in endometrial carcinoma.

  9. Determination of the ratio of b-quark fragmentation fractions fs/fd in pp collisions at s=7TeV with the ATLAS detector

    DOE PAGES-Beta [OSTI]

    Aad, G.

    2015-12-30

    With an integrated luminosity of 2.47 fb-1 recorded by the ATLAS experiment at the LHC, the exclusive decays B0s?J/?? and B0d?J/?K*0 of B mesons produced in pp collisions at ?s=7 TeV are used to determine the ratio of fragmentation fractions fs/fd. From the observed B0s?J/?? and B0d?J/?K*0 yields, the quantity (fs/fd)[B(B0s?J/??)/B(B0d?J/?K*0)] is measured to be 0.1990.004(stat)0.008(syst). Using a recent theory prediction for [B(B0s?J/??)/B(B0d?J/?K*0)] yields (fs/fd)=0.2400.004(stat)0.010(syst)0.017(th). As a result, it is based on a new approach that provides a significant improvement of the world average.

  10. High glucose induces activation of NF-κB inflammatory signaling through IκBα sumoylation in rat mesangial cells

    SciTech Connect (OSTI)

    Huang, Wei; Department of Endocrinology, The People’s Hospital of Xindu, Xindu, Sichuang, 610500 ; Xu, Ling; Zhou, Xueqin; Department of Endocrinology, The People’s Hospital of Leshan, Sichuang ; Gao, Chenlin; Yang, Maojun; Chen, Guo; Zhu, Jianhua; Jiang, Lan; Gan, Huakui; Gou, Fang; Feng, Hong; Peng, Juan; Xu, Yong

    2013-08-30

    Highlights: •The expression of SUMO1, SUMO2/3 under high glucose was obviously enhanced. •High glucose induced degradation of IκBα and activation of NF-κB pathway. •Sumoylation of IκBα in high glucose were significantly decreased. •The proteasome inhibitor MG132 could partially revert the degradation of IκBα. -- Abstract: The posttranslational modification of proteins by small ubiquitin-like modifiers (SUMOs) has emerged as an important regulatory mechanism for the alteration of protein activity, stability, and cellular localization. The latest research demonstrates that sumoylation is extensively involved in the regulation of the nuclear factor κB (NF-κB) pathway, which plays a critical role in the regulation of inflammation and contributes to fibrosis in diabetic nephropathy (DN). However, the role of sumoylation in the regulation of NF-κB signaling in DN is still unclear. In the present study, we cultured rat glomerular mesangial cells (GMCs) stimulated by high glucose and divided GMCs into six groups: normal glucose group (5.6 mmol/L), high glucose groups (10, 20, and 30 mmol/L), mannitol group (i.e., osmotic control group), and MG132 intervention group (30 mmol/L glucose with MG132, a proteasome inhibitor). The expression of SUMO1, SUMO2/3, IκBα, NF-κBp65, and monocyte chemotactic protein 1 (MCP-1) was measured by Western blot, reverse-transcription polymerase chain reaction, and indirect immunofluorescence laser scanning confocal microscopy. The interaction between SUMO1, SUMO2/3, and IκBα was observed by co-immunoprecipitation. The results showed that the expression of SUMO1 and SUMO2/3 was dose- and time-dependently enhanced by high glucose (p < 0.05). However, the expression of IκBα sumoylation in high glucose was significantly decreased compared with the normal glucose group (p < 0.05). The expression of IκBα was dose- and time-dependently decreased, and NF-κBp65 and MCP-1 were increased under high glucose conditions, which

  11. Thermal Reactions of Uranium Metal, UO2, U3O8, UF4, and UO2F2 with NF3 to Produce UF6

    SciTech Connect (OSTI)

    McNamara, Bruce K.; Scheele, Randall D.; Kozelisky, Anne E.; Edwards, Matthew K.

    2009-11-01

    he objective of this paper is to demonstrate that NF3 fluorinates uranium metal, UO2, UF4, UO3, U3O8, and UO2F22H2O to produce the volatile UF6 at temperatures between 100 and 500?C. Thermogravimetric reaction profiles are described that reflect changes in the uranium oxidation state and discrete chemical speciation. Differences in the onset temperatures for each system indicate that NF3-substrate interactions are important for the temperature at which NF3 reacts: U metal > UO3 > UO2 > UO2F2 > UF4 and in fact may indicate different fluorination mechanisms for these various substrates. These studies demonstrate that NF3 is a potential replacement fluorinating agent in the existing nuclear fuel cycle and in oft-proposed actinide volatility reprocessing.

  12. Mercury FS.pdf

    Office of Environmental Management (EM)

  13. Microstructural evolution of NF709 (20Cr–25Ni–1.5MoNbTiN) under neutron irradiation

    SciTech Connect (OSTI)

    Kim, Byoungkoo; Tan, Lizhen; Xu, C.; Yang, Yong; Zhang, Xuan; Li, Meimei

    2015-12-30

    In this study, because of its superior creep and corrosion resistance as compared with general austenitic stainless steels, NF709 has emerged as a candidate structural material for advanced nuclear reactors. To obtain fundamental information about the radiation resistance of this material, this study examined the microstructural evolution of NF709 subjected to neutron irradiation to 3 displacements per atom at 500 °C. Transmission electron microscopy, scanning electron microscopy, and high-energy x-ray diffraction were employed to characterize radiation-induced segregation, Frank loops, voids, as well as the formation and reduction of precipitates. Radiation hardening of ~76% was estimated by nanoindentation, approximately consistent with the calculation according to the dispersed barrier-hardening model, suggesting Frank loops as the primary hardening source.

  14. Microstructural evolution of NF709 (20Cr–25Ni–1.5MoNbTiN) under neutron irradiation

    DOE PAGES-Beta [OSTI]

    Kim, Byoungkoo; Tan, Lizhen; Xu, C.; Yang, Yong; Zhang, Xuan; Li, Meimei

    2015-12-30

    In this study, because of its superior creep and corrosion resistance as compared with general austenitic stainless steels, NF709 has emerged as a candidate structural material for advanced nuclear reactors. To obtain fundamental information about the radiation resistance of this material, this study examined the microstructural evolution of NF709 subjected to neutron irradiation to 3 displacements per atom at 500 °C. Transmission electron microscopy, scanning electron microscopy, and high-energy x-ray diffraction were employed to characterize radiation-induced segregation, Frank loops, voids, as well as the formation and reduction of precipitates. Radiation hardening of ~76% was estimated by nanoindentation, approximately consistent withmore » the calculation according to the dispersed barrier-hardening model, suggesting Frank loops as the primary hardening source.« less

  15. Simulated (n,f) cross section of isomeric 235m-U

    SciTech Connect (OSTI)

    Becker, J; Britt, H; Younes, W

    2003-12-18

    The neutron-induced fission cross section on the {sup 235}U, T{sub 1/2} {approx} 26 min isomer has been deduced for incident neutron energies in the range E{sub n}=0.1-2.5 MeV, using the surrogate-reaction technique. In this technique, {sup 236}U fission probabilities measured in the {sup 234}U(t, pf) reaction have been converted into {sup 235}U(n,f) and {sup 235m}U(n,f) cross sections, using reaction theory to compensate for the differences in angular-momentum and parity distributions in the fissioning systems, transferred by the (t,p) and neutron-induced reactions. Based on the comparison between the {sup 235}U(n,f) cross section extracted in this work and independent experimental data, the deduced {sup 235m}U(n,f) cross section is believed to be reliable to 20% below E{sub n} {approx} 0.5 MeV and 10% at higher energies. The surrogate-reaction technique, its validation in the case of the {sup 235}U(n,f) cross section, and the deduced {sup 235m}U(n,f) cross section are discussed. Validation of this method allows (n,f) cross sections for many short-lived nuclei, as well as isomeric nuclei, to be extracted from measured fission probabilities.

  16. DOE/EIS-0203-SA-07 DOE/EA-1148-SA-01 DOE/EIS-0250F-S-1-SA-02

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    SA-07 DOE/EA-1148-SA-01 DOE/EIS-0250F-S-1-SA-02 Draft SUPPLEMENT ANALYSIS TWO PROPOSED SHIPMENTS OF COMMERCIAL SPENT NUCLEAR FUEL TO IDAHO NATIONAL LABORATORY FOR RESEARCH AND DEVELOPMENT PURPOSES Idaho Operations Office U.S. DEPARTMENT OF ENERGY June 2015 Commercial Fuel Shipments SA DOE/EIS-0203-SA-07 June 2015 CONVERSION FACTORS Metric to English English to Metric Multiply by To get Multiply by To get Area Square kilometers 247.1 Acres Square kilometers 0.3861 Square miles Square meters

  17. Subneurotoxic copper(II)-induced NF-κB-dependent microglial activation is associated with mitochondrial ROS

    SciTech Connect (OSTI)

    Hu, Zhuqin; Yu, Fengxiang; Gong, Ping; Qiu, Yu; Zhou, Wei; Cui, Yongyao; Li, Juan Chen, Hongzhuan

    2014-04-15

    Microglia-mediated neuroinflammation and the associated neuronal damage play critical roles in the pathogenesis of neurodegenerative disorders. Evidence shows an elevated concentration of extracellular copper(II) in the brains of these disorders, which may contribute to neuronal death through direct neurotoxicity. Here we explored whether extracellular copper(II) triggers microglial activation. Primary rat microglia and murine microglial cell line BV-2 cells were cultured and treated with copper(II). The content of tumor necrosis factor-α (TNF-α) and nitric oxide in the medium was determined. Extracellular hydrogen peroxide was quantified by a fluorometric assay with Amplex Red. Mitochondrial superoxide was measured by MitoSOX oxidation. At subneurotoxic concentrations, copper(II) treatment induced a dose- and time-dependent release of TNF-α and nitric oxide from microglial cells, and caused an indirect, microglia-mediated neurotoxicity that was blocked by inhibition of TNF-α and nitric oxide production. Copper(II)-initiated microglial activation was accompanied with reduced IkB-α expression as well as phosphorylation and translocation of nuclear factor-κB (NF-κB) p65 and was blocked by NF-κB inhibitors (BAY11-7082 and SC-514). Moreover, copper(II) treatment evoked a rapid release of hydrogen peroxide from microglial cells, an effect that was not affected by NADPH oxidase inhibitors. N-acetyl-cysteine, a scavenger of reactive oxygen species (ROS), abrogated copper(II)-elicited microglial release of TNF-α and nitric oxide and subsequent neurotoxicity. Importantly, mitochondrial production of superoxide, paralleled to extracellular release of hydrogen peroxide, was induced after copper(II) stimulation. Our findings suggest that extracellular copper(II) at subneurotoxic concentrations could trigger NF-κB-dependent microglial activation and subsequent neurotoxicity. NADPH oxidase-independent, mitochondria-derived ROS may be involved in this activation

  18. SENP1 inhibition induces apoptosis and growth arrest of multiple myeloma cells through modulation of NF-κB signaling

    SciTech Connect (OSTI)

    Xu, Jun; Sun, Hui-Yan; Xiao, Feng-Jun; Wang, Hua; Yang, Yang; Wang, Lu; Gao, Chun-Ji; Guo, Zi-Kuan; Wu, Chu-Tse; Wang, Li-Sheng

    2015-05-01

    SUMO/sentrin specific protease 1 (Senp1) is an important regulation protease in the protein sumoylation, which affects the cell cycle, proliferation and differentiation. The role of Senp1 mediated protein desumoylation in pathophysiological progression of multiple myeloma is unknown. In this study, we demonstrated that Senp1 is overexpressed and induced by IL-6 in multiple myeloma cells. Lentivirus-mediated Senp1 knockdown triggers apoptosis and reduces viability, proliferation and colony forming ability of MM cells. The NF-κB family members including P65 and inhibitor protein IkBα play important roles in regulation of MM cell survival and proliferation. We further demonstrated that Senp1 inhibition decreased IL-6-induced P65 and IkBα phosphorylation, leading to inactivation of NF-kB signaling in MM cells. These results delineate a key role for Senp1in IL-6 induced proliferation and survival of MM cells, suggesting it may be a potential new therapeutic target in MM. - Highlights: • Senp1 is overexpressed and induced by IL-6 in multiple myeloma cells. • Senp1 knockdown triggers apoptosis and reduces proliferation of MM cells. • Senp1 inhibition decreased IL-6-induced P65 and IkBα phosphorylation.

  19. Oxaliplatin antagonizes HIV-1 latency by activating NF-κB without causing global T cell activation

    SciTech Connect (OSTI)

    Zhu, Xiaoli; Liu, Sijie; Wang, Pengfei; Qu, Xiying; Wang, Xiaohui; Zeng, Hanxian; Chen, Huabiao; Zhu, Huanzhang

    2014-07-18

    Highlights: • The chemotherapeutic drug oxaliplatin reactivates latent HIV-1 in this cell line model of HIV-1 latency. • Reactivation is synergized when oxaliplatin is used in combination with valproic acid. • Oxaliplatin reactivates latent HIV-1 through activation of NF-kB and does not induce T cell activation. - Abstract: Reactivation of latent HIV-1 is a promising strategy for the clearance of the viral reservoirs. Because of the limitations of current agents, identification of new latency activators is urgently required. Using an established model of HIV-1 latency, we examined the effect of Oxaliplatin on latent HIV-1 reactivation. We showed that Oxaliplatin, alone or in combination with valproic acid (VPA), was able to reactivate HIV-1 without inducing global T cell activation. We also provided evidence that Oxaliplatin reactivated HIV-1 expression by inducing nuclear factor kappa B (NF-κB) nuclear translocation. Our results indicated that Oxaliplatin could be a potential drug candidate for anti-latency therapies.

  20. Urotensin II increases foam cell formation by repressing ABCA1 expression through the ERK/NF-κB pathway in THP-1 macrophages

    SciTech Connect (OSTI)

    Wang, Yan; Wu, Jian-Feng; Tang, Yan-Yan; Zhang, Min; Li, Yuan; Chen, Kong; Zeng, Meng-Ya; Yao, Feng; Xie, Wei; Zheng, Xi-Long; Zeng, Gao-Feng; Tang, Chao-Ke

    2014-10-03

    Highlights: • U II reduces cholesterol efflux in THP-1 macrophages. • U II decreases the expression of ABCA1. • Inhibition of the ERK/NF-κB pathway reduces U II effects on ABCA1 expression and cholesterol efflux. - Abstract: Objective: Foam cell formation in the arterial wall plays a key role in the development of atherosclerosis. Recent studies showed that Urotensin II (U II) is involved in the pathogenesis of atherosclerosis. Here we examined the effects of human U II on ATP-binding cassette transporter A1 (ABCA1) expression and the underlying mechanism in THP-1 macrophages. Methods and results: Cultured THP-1 macrophages were treated with U II, followed by measuring the intracellular lipid contents, cholesterol efflux and ABCA1 levels. The results showed that U II dramatically decreased ABCA1 levels and impaired cholesterol efflux. However, the effects of U II on ABCA1 protein expression and cellular cholesterol efflux were partially reversed by inhibition of extracellular signal regulated kinase 1/2 (ERK1/2) and nuclear factor kappa B (NF-κB) activity, suggesting the potential roles of ERK1/2 and NF-κB in ABCA1 expression, respectively. Conclusion: Our current data indicate that U II may have promoting effects on the progression of atherosclerosis, likely through suppressing ABCA1 expression via activation of the ERK/NF-κB pathway and reducing cholesterol efflux to promote macrophage foam cell formation.

  1. Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

    SciTech Connect (OSTI)

    Verhaak, Roel GW; Hoadley, Katherine A; Purdom, Elizabeth; Wang, Victoria; Qi, Yuan; Wilkerson, Matthew D; Miller, C Ryan; Ding, Li; Golub, Todd; Mesirov, Jill P; Alexe, Gabriele; Lawrence, Michael; O'Kelly, Michael; Tamayo, Pablo; Weir, Barbara A; Gabriel, Stacey; Winckler, Wendy; Gupta, Supriya; Jakkula, Lakshmi; Feiler, Heidi S; Hodgson, J Graeme; James, C David; Sarkaria, Jann N; Brennan, Cameron; Kahn, Ari; Spellman, Paul T; Wilson, Richard K; Speed, Terence P; Gray, Joe W; Meyerson, Matthew; Getz, Gad; Perou, Charles M; Hayes, D Neil; Network, The Cancer Genome Atlas Research

    2009-09-03

    The Cancer Genome Atlas Network recently cataloged recurrent genomic abnormalities in glioblastoma multiforme (GBM). We describe a robust gene expression-based molecular classification of GBM into Proneural, Neural, Classical, and Mesenchymal subtypes and integrate multidimensional genomic data to establish patterns of somatic mutations and DNA copy number. Aberrations and gene expression of EGFR, NF1, and PDGFRA/IDH1 each define the Classical, Mesenchymal, and Proneural subtypes, respectively. Gene signatures of normal brain cell types show a strong relationship between subtypes and different neural lineages. Additionally, response to aggressive therapy differs by subtype, with the greatest benefit in the Classical subtype and no benefit in the Proneural subtype. We provide a framework that unifies transcriptomic and genomic dimensions for GBM molecular stratification with important implications for future studies.

  2. Metastatic function of BMP-2 in gastric cancer cells: The role of PI3K/AKT, MAPK, the NF-{kappa}B pathway, and MMP-9 expression

    SciTech Connect (OSTI)

    Kang, Myoung Hee; Oh, Sang Cheul; Kang, Han Na; Kim, Jung Lim; Kim, Jun Suk

    2011-07-15

    Bone morphogenetic proteins (BMPs) have been implicated in tumorigenesis and metastatic progression in various types of cancer cells, but the role and cellular mechanism in the invasive phenotype of gastric cancer cells is not known. Herein, we determined the roles of phosphoinositide 3-kinase (PI3K)/AKT, extracellular signal-regulated protein kinase (ERK), nuclear factor (NF)-{kappa}B, and matrix metalloproteinase (MMP) expression in BMP-2-mediated metastatic function in gastric cancer. We found that stimulation of BMP-2 in gastric cancer cells enhanced the phosphorylation of AKT and ERK. Accompanying activation of AKT and ERK kinase, BMP-2 also enhanced phosphorylation/degradation of I{kappa}B{alpha} and the nuclear translocation/activation of NF-{kappa}B. Interestingly, blockade of PI3K/AKT and ERK signaling using LY294002 and PD98059, respectively, significantly inhibited BMP-2-induced motility and invasiveness in association with the activation of NF-{kappa}B. Furthermore, BMP-2-induced MMP-9 expression and enzymatic activity was also significantly blocked by treatment with PI3K/AKT, ERK, or NF-{kappa}B inhibitors. Immunohistochemistry staining of 178 gastric tumor biopsies indicated that expression of BMP-2 and MMP-9 had a significant positive correlation with lymph node metastasis and a poor prognosis. These results indicate that the BMP-2 signaling pathway enhances tumor metastasis in gastric cancer by sequential activation of the PI3K/AKT or MAPK pathway followed by the induction of NF-{kappa}B and MMP-9 activity, indicating that BMP-2 has the potential to be a therapeutic molecular target to decrease metastasis.

  3. Nuclear NF-?B Expression Correlates With Outcome Among Patients With Head and Neck Squamous Cell Carcinoma Treated With Primary Chemoradiation Therapy

    SciTech Connect (OSTI)

    Balermpas, Panagiotis [Department of Radiation Therapy and Oncology, J. W. Goethe University Frankfurt am Main, Frankfurt (Germany)] [Department of Radiation Therapy and Oncology, J. W. Goethe University Frankfurt am Main, Frankfurt (Germany); Michel, Yvonne [Senckenberg Institute of Pathology, J. W. Goethe University Frankfurt am Main, Frankfurt (Germany)] [Senckenberg Institute of Pathology, J. W. Goethe University Frankfurt am Main, Frankfurt (Germany); Wagenblast, Jens [Department of Otorhinolaryngology, J. W. Goethe University Frankfurt am Main, Frankfurt (Germany)] [Department of Otorhinolaryngology, J. W. Goethe University Frankfurt am Main, Frankfurt (Germany); Seitz, Oliver [Department of Maxillofacial Surgery, J. W. Goethe University Frankfurt am Main, Frankfurt (Germany)] [Department of Maxillofacial Surgery, J. W. Goethe University Frankfurt am Main, Frankfurt (Germany); Sipek, Florian; Rdel, Franz; Rdel, Claus [Department of Radiation Therapy and Oncology, J. W. Goethe University Frankfurt am Main, Frankfurt (Germany)] [Department of Radiation Therapy and Oncology, J. W. Goethe University Frankfurt am Main, Frankfurt (Germany); Fokas, Emmanouil, E-mail: emmanouil.fokas@kgu.de [Department of Radiation Therapy and Oncology, J. W. Goethe University Frankfurt am Main, Frankfurt (Germany)] [Department of Radiation Therapy and Oncology, J. W. Goethe University Frankfurt am Main, Frankfurt (Germany)

    2013-07-15

    Background: To examine whether nuclear NF-?B expression correlates with outcome in patients with head and neck squamous cell carcinoma (HNSCC) treated with primary chemoradiation therapy (CRT). Methods and Materials: Between 2007 and 2010, 101 patients with locally advanced primary HNSCC were treated with definitive simultaneous CRT. Pretreatment biopsy specimens were analyzed for NF-?B p65 (RelA) nuclear immunoreactivity. A sample was assigned to be positive with more than 5% positive nuclear expression. The predictive relevance of NF-?B and clinicopathologic factors for overall survival (OS), progression-free survival (PFS), local progression-free survival (LPFS), and metastasis-free survival (DMFS) was examined by univariate and multivariate analysis. Results: No significant differences between the groups were observed with regard to age, sex, total radiation dose, fractionation mode, total chemotherapy applied, T stage or grading. Patients with p65 nuclear positive biopsy specimens showed significantly a higher rate of lymph node metastasis (cN2c or cN3 status, P=.034). Within a mean follow-up time of 25 months (range, 2.33-62.96 months) OS, PFS, and DMFS were significantly poorer in the p65 nuclear positive group (P=.008, P=.027, and P=.008, respectively). These correlations remained significant in multivariate analysis. Conclusion: NF-?B/p65 nuclear expression is associated with increased lymphatic and hematogenous tumor dissemination and decreased survival in HNSCC patients treated with primary CRT. Our results may foster further investigation of a predictive relevance of NF-?B/p65 and its role as a suitable target for a molecular-based targeted therapy in HNSCC cancer.

  4. Observation of the wavepacket dynamics on the {sup 1}B{sub 2}({sup 1}?{sub u}{sup +}) state of CS{sub 2} by sub-20 fs photoelectron imaging using 159 nm probe pulses

    SciTech Connect (OSTI)

    Spesyvtsev, R.; Horio, T.; Suzuki, Y.-I.; Suzuki, T.

    2015-02-21

    The wavepacket dynamics of CS{sub 2} after photoexcitation to the {sup 1}B{sub 2}({sup 1}?{sub u}{sup +}) state at 198 nm are studied by time-resolved photoelectron imaging using sub-20 fs 159 nm pulses, which enable single photon ionization from the entire region of the {sup 1}B{sub 2} potential energy surface. The time-energy map of the photoelectron intensity reveals vibrational motions along the symmetric stretching and bending coordinates. The time-energy map of the photoelectron anisotropy parameter exhibits time-evolution within single oscillation periods of the ?{sub 1} and ?{sub 2} modes, which is attributed to variation of the excited state electronic character along these vibrational coordinates. The initially populated {sup 1}B{sub 2} state evolves with two time constants of 107 and 394 fs.

  5. Coactivation of the PI3K/Akt and ERK signaling pathways in PCB153-induced NF-κB activation and caspase inhibition

    SciTech Connect (OSTI)

    Liu, Changjiang; Yang, Jixin; Fu, Wenjuan; Qi, Suqin; Wang, Chenmin; Quan, Chao; Yang, Kedi

    2014-06-15

    Polychlorinated biphenyls (PCBs) are a group of persistent and widely distributed environmental pollutants that have various deleterious effects, e.g., neurotoxicity, endocrine disruption and reproductive abnormalities. In order to verify the hypothesis that the PI3K/Akt and MAPK pathways play important roles in hepatotoxicity induced by PCBs, Sprague–Dawley (SD) rats were dosed with PCB153 intraperitoneally at 0, 4, 16 and 32 mg/kg for five consecutive days; BRL cells (rat liver cell line) were treated with PCB153 (0, 1, 5, and 10 μM) for 24 h. Results indicated that the PI3K/Akt and ERK pathways were activated in vivo and in vitro after exposure to PCB153, and protein levels of phospho-Akt and phospho-ERK were significantly increased. Nuclear factor-κB (NF-κB) activation and caspase-3, -8 and -9 inhibition caused by PCB153 were also observed. Inhibiting the ERK pathway significantly attenuated PCB153-induced NF-κB activation, whereas inhibiting the PI3K/Akt pathway hardly influenced phospho-NF-κB level. However, inhibiting the PI3K/Akt pathway significantly elevated caspase-3, -8 and -9 activities, while the ERK pathway only synergistically regulated caspase-9. Proliferating cell nuclear antigen (PCNA), a reliable indicator of cell proliferation, was also induced. Moreover, PCB153 led to hepatocellular hypertrophy and elevated liver weight. Taken together, PCB153 leads to aberrant proliferation and apoptosis of hepatocytes through NF-κB activation and caspase inhibition, and coactivated PI3K/Akt and ERK pathways play critical roles in PCB153-induced hepatotoxicity. - Highlights: • PCB153 led to hepatotoxicity through NF-κB activation and caspase inhibition. • The PI3K/Akt and ERK pathways were coactivated in vivo and in vitro by PCB153. • The ERK pathway regulated levels of phospho-NF-κB and caspase-9. • The PI3K/Akt pathway regulated levels of caspase-3, -8 and -9.

  6. Moderate extracellular acidification inhibits capsaicin-induced cell death through regulating calcium mobilization, NF-{kappa}B translocation and ROS production in synoviocytes

    SciTech Connect (OSTI)

    Hu, Fen; Yang, Shuang; Zhao, Dan; Zhu, Shuyan; Wang, Yuxiang; Li, Junying

    2012-07-20

    Highlights: Black-Right-Pointing-Pointer Moderate extracellular acidification regulates intracellular Ca{sup 2+} mobilization. Black-Right-Pointing-Pointer Moderate acidification activates NF-{kappa}B nuclear translocation in synoviocytes. Black-Right-Pointing-Pointer Moderate acidification depresses the ROS production induced by capsaicin. Black-Right-Pointing-Pointer Moderate acidification inhibits capsaicin-caused synoviocyte death. -- Abstract: We previously show the expression of transient receptor potential vanilloid 1 (TRPV1) in primary synoviocytes from collagen-induced arthritis (CIA) rats. Capsaicin and lowered extracellular pH from 7.4 to 5.5 induce cell death through TRPV1-mediated Ca{sup 2+} entry and reactive oxygen species (ROS) production. However, under the pathological condition in rheumatoid arthritis, the synovial fluid is acidified to a moderate level (about pH 6.8). In the present study, we examined the effects of pH 6.8 on the TRPV1-mediated cell death. Our finding is different or even opposite from what was observed at pH 5.5. We found that the moderate extracellular acidification (from pH 7.4 to 6.8) inhibited the capsaicin-induced Ca{sup 2+} entry through attenuating the activity of TRPV1. In the mean time, it triggered a phospholipse C (PLC)-related Ca{sup 2+} release from intracellular stores. The nuclear translocation of NF-{kappa}B was found at pH 6.8, and this also depends on PLC activation. Moreover, the capsaicin-evoked massive ROS production and cell death were depressed at pH 6.8, both of which are dependent on the activation of PLC and NF-{kappa}B. Taken together, these results suggested that the moderate extracellular acidification inhibited the capsaicin-induced synoviocyte death through regulating Ca{sup 2+} mobilization, activating NF-{kappa}B nuclear translocation and depressing ROS production.

  7. Sargahydroquinoic acid inhibits TNFα-induced AP-1 and NF-κB signaling in HaCaT cells through PPARα activation

    SciTech Connect (OSTI)

    Jeon, Youngsic; Jung, Yujung; Kim, Min Cheol; Kwon, Hak Cheol; Kang, Ki Sung; Kim, Yong Kee; Kim, Su-Nam

    2014-08-08

    Highlights: • SHQA increases PPARα/γ transactivation and inhibits MMP-2/-9 expression. • SHQA inhibits TNFα-induced AP-1 and MAPK signaling. • SHQA inhibits TNFα-induced p65 translocation and IκBα phosphorylation. • SHQA inhibits TNFα-induced AP-1 and NF-κB signaling via PPARα. - Abstract: Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors and expressed in various cell types in the skin, including keratinocytes, fibroblasts and infiltrating immune cells. Thus, their ligands are targets for the treatment of various skin disorders, such as photo-aging and chronological aging of skin. Intensive studies have revealed that PPARα/γ functions in photo-aging and age-related inflammation by regulating matrix metalloproteinases (MMPs) via activator protein-1 (AP-1) and nuclear factor kappa B (NF-κB). However, the detailed mechanism of PPARα/γ’s role in skin aging has not yet been elucidated. In this study, we confirmed that sargahydroquinoic acid (SHQA) as a PPARα/γ ligand significantly decreased Tumor Necrosis Factor-alpha (TNFα)-induced MMP-2/-9 expression by downregulating TNFα-induced transcription factors, subsequently reducing IκBα degradation and blocking NF-κB p65 nuclear translocation in HaCaT human epidermal keratinocyte cells. Treatment of cells with SHQA and GW6471 (PPARα antagonist) not bisphenol A diglycidyl ether (PPARγ antagonists), reversed the effect on TNFα-induced inflammatory signaling pathway activation. Taken together, our data suggest that SHQA inhibit TNFα-induced MMP-2/-9 expression and age-related inflammation by suppressing AP-1 and NF-κB pathway via PPARα.

  8. Gastrodin stimulates anticancer immune response and represses transplanted H22 hepatic ascitic tumor cell growth: Involvement of NF-?B signaling activation in CD4 + T cells

    SciTech Connect (OSTI)

    Shu, Guangwen; Yang, Tianming; Wang, Chaoyuan; Su, Hanwen; Xiang, Meixian

    2013-06-15

    Gastrodia elata Blume (G. elata) is a famous restorative food in East Asia. It can be used as an auxiliary reagent in hepatocellular carcinoma (HCC) treatment. Previous studies unveiled that G. elata exhibited immunomodulatory activities. To explore the active ingredients contributing to its immunomodulatory activities, gastrodin, vanillin, and parishin B were purified from G. elata and their anti-HCC effects were assessed in vivo. Among these compounds, only gastrodin was capable of repressing transplanted H22 ascitic hepatic tumor cell growth in vivo with low toxicity. Further investigations were designed to explore the effects of gastrodin on the immune system of tumor-bearing mice and potential molecular mechanisms underlying these effects. Our data showed that gastrodin ameliorated tumor cell transplantation-induced activation of endogenous pro-apoptotic pathway in CD4 + T cells and abnormalities in serum cytokine profiles in host animals. These events enhanced cytotoxic activities of natural killer and CD8 + T cells against H22 hepatic cancer cells. Gastrodin administration specifically upregulated mRNA levels of several nuclear factor ?B (NF-?B) responsive genes in CD4 + T cells but not in CD8 + T cells. Chromatin immunoprecipitation assay showed that gastrodin increased the association of NF-?B p65 subunit to the promoter regions of IL-2 and Bcl-2 encoding genes in CD4 + T cells. Our investigations demonstrated that gastrodin is the main active ingredient contributing to the anticancer immunomodulatory properties of G. elata. Promoting NF-?B-mediated gene transcription in CD4 + T cells is implicated in its immunomodulatory activity. - Highlights: Gastrodin stimulates anticancer immune response. Gastrodin represses tumor transplantation-induced CD4 + T cell apoptosis. Gastrodin activates NF-?B activity in CD4 + T cells.

  9. Analysis of the structure, configuration, and sizing of Cu and Cu oxide nanoparticles generated by fs laser ablation of solid target in liquids

    SciTech Connect (OSTI)

    Santillan, J. M. J.; Videla, F. A.; Schinca, D. C.; Scaffardi, L. B.; Fernandez van Raap, M. B.

    2013-04-07

    We report on the analysis of structure, configuration, and sizing of Cu and Cu oxide nanoparticles (Nps) produced by femtosecond (fs) laser ablation of solid copper target in liquids. Laser pulse energy ranged between 500 {mu}J and 50 {mu}J. Water and acetone were used to produce the colloidal suspensions. The study was performed through optical extinction spectroscopy using Mie theory to fit the full experimental spectra, considering free and bound electrons size dependent contributions to the metal dielectric function. Raman spectroscopy and AFM technique were also used to characterize the sample. Considering the possible oxidation of copper during the fabrication process, two species (Cu and Cu{sub 2}O) arranged in two structures (bare core or core-shell) and in two configuration types (Cu-Cu{sub 2}O or Cu{sub 2}O-Cu) were considered for the fitting depending on the laser pulse energy and the surrounding media. For water at high energy, it can be observed that a Cu-Cu{sub 2}O configuration fits the experimental spectra of the colloidal suspension, while for decreasing energy and below a certain threshold, a Cu{sub 2}O-Cu configuration needs to be included for the optimum fit. Both species coexist for energies below 170 {mu}J for water. On the other hand, for acetone at high energy, optimum fit of the full spectrum suggests the presence a bimodal Cu-Cu{sub 2}O core-shell Nps distribution while for decreasing energy and below a 70 {mu}J threshold energy value, Cu{sub 2}O-Cu core-shell Nps must be included, together with the former configuration, for the fit of the full spectrum. We discuss possible reasons for the changes in the structural configuration of the core-shell Nps.

  10. Stevioside ameliorates high-fat diet-induced insulin resistance and adipose tissue inflammation by downregulating the NF-{kappa}B pathway

    SciTech Connect (OSTI)

    Wang, Zhiquan; Xue, Liqiong; Guo, Cuicui; Han, Bing; Pan, Chunming; Zhao, Shuangxia; Song, Huaidong; Ma, Qinyun

    2012-01-27

    Highlights: Black-Right-Pointing-Pointer Stevioside ameliorates high-fat diet-induced insulin resistance. Black-Right-Pointing-Pointer Stevioside alleviates the adipose tissue inflammation. Black-Right-Pointing-Pointer Stevioside reduces macrophages infiltration into the adipose tissue. Black-Right-Pointing-Pointer Stevioside suppresses the activation of NF-{kappa}B in the adipose tissue. -- Abstract: Accumulating evidence suggests that adipose tissue is the main source of pro-inflammatory molecules that predispose individuals to insulin resistance. Stevioside (SVS) is a widely used sweetener with multiple beneficial effects for diabetic patients. In this study, we investigated the effect of SVS on insulin resistance and the pro-inflammatory state of adipose tissue in mice fed with a high-fat diet (HFD). Oral administration of SVS for 1 month had no effect on body weight, but it significantly improved fasting glucose, basal insulin levels, glucose tolerance and whole body insulin sensitivity. Interestingly, these changes were accompanied with decreased expression levels of several inflammatory cytokines in adipose tissue, including TNF-{alpha}, IL6, IL10, IL1{beta}, KC, MIP-1{alpha}, CD11b and CD14. Moreover, macrophage infiltration in adipose tissue was remarkably reduced by SVS. Finally, SVS significantly suppressed the nuclear factor-kappa b (NF-{kappa}B) signaling pathway in adipose tissue. Collectively, these results suggested that SVS may ameliorate insulin resistance in HFD-fed mice by attenuating adipose tissue inflammation and inhibiting the NF-{kappa}B pathway.

  11. ROS and NF-{kappa}B are involved in upregulation of IL-8 in A549 cells exposed to multi-walled carbon nanotubes

    SciTech Connect (OSTI)

    Ye Shefang Wu Yihui; Hou Zhenqing; Zhang Qiqing

    2009-02-06

    Carbon nanotubes (CNTs) have potential applications in biosensors, tissue engineering, and biomedical devices because of their unique physico-chemical, electronic and mechanical properties. However, there is limited literature data available concerning the biological properties and toxicity of CNTs. This study aimed to assess the toxicity exhibited by multi-walled CNTs (MWCNTs) and to elucidate possible molecular mechanisms underlying the biological effects of MWCNTs in A549 cells. Exposing A549 cells to MWCNTs led to cell death, changes in cell size and complexity, reactive oxygen species (ROS) production, interleukin-8 (IL-8) gene expression and nuclear factor (NF)-{kappa}B activation. Treatment of A549 cells with antioxidants prior to adding MWCNTs decreased ROS production and abrogated expression of IL-8 mRNA. Pretreatment of A549 cells with NF-{kappa}B inhibitors suppressed MWCNTs-induced IL-8 mRNA expression. These results indicate that MWCNTs are able to induce expression of IL-8 in A549 cells, at least in part, mediated by oxidative stress and NF-{kappa}B activation.

  12. Neutron and proton electric dipole moments from Nf=2+1 domain-wall fermion lattice QCD

    DOE PAGES-Beta [OSTI]

    Shintani, Eigo; Blum, Thomas; Izubuchi, Taku; Soni, Amarjit

    2016-05-05

    We present a lattice calculation of the neutron and proton electric dipole moments (EDM’s) with Nf = 2 + 1 flavors of domain-wall fermions. The neutron and proton EDM form factors are extracted from three-point functions at the next-to-leading order in the θ vacuum of QCD. In this computation, we use pion masses 330 and 420 MeV and 2.7 fm3 lattices with Iwasaki gauge action and a 170 MeV pion and 4.6 fm3 lattice with I-DSDR gauge action, all generated by the RBC and UKQCD collaborations. The all-mode-averaging technique enables an efficient, high statistics calculation; however the statistical errors onmore » our results are still relatively large, so we investigate a new direction to reduce them, reweighting with the local topological charge density which appears promising. Furthermore, we discuss the chiral behavior and finite size effects of the EDM’s in the context of baryon chiral perturbation theory.« less

  13. Ascorbic acid suppresses endotoxemia and NF-κB signaling cascade in alcoholic liver fibrosis in guinea pigs: A mechanistic approach

    SciTech Connect (OSTI)

    Abhilash, P.A.; Harikrishnan, R.; Indira, M.

    2014-01-15

    Alcohol consumption increases the small intestinal bacterial overgrowth (SIBO) and intestinal permeability of endotoxin. The endotoxin mediated inflammatory signaling plays a major role in alcoholic liver fibrosis. We evaluated the effect of ascorbic acid (AA), silymarin and alcohol abstention on the alcohol induced endotoxemia and NF-κB activation cascade pathway in guinea pigs (Cavia porcellus). Guinea pigs were administered ethanol at a daily dose of 4 g/kg b.wt for 90 days. After 90 days, ethanol administration was stopped. The ethanol treated animals were divided into abstention, silymarin (250 mg/kg b.wt) and AA (250 mg/kg b.wt) supplemented groups and maintained for 30 days. The SIBO, intestinal permeability and endotoxin were significantly increased in the ethanol group. The mRNA expressions of intestinal proteins claudin, occludin and zona occludens-1 were significantly decreased in ethanol group. The mRNA levels of inflammatory receptors, activity of IKKβ and the protein expressions of phospho-IκBα, NF-κB, TNF-α, TGF-β{sub 1} and IL-6 were also altered in ethanol group. The expressions of fibrosis markers α-SMA, α{sub 1} (I) collagen and sirius red staining in the liver revealed the induction of fibrosis. But the supplementation of AA could induce greater reduction of ethanol induced SIBO, intestinal barrier defects, NF-κB activation and liver fibrosis than silymarin. The possible mechanism may be the inhibitory effect of AA on SIBO, intestinal barrier defect and IKKβ, which decreased the activation of NF-κB and synthesis of cytokines. This might have led to suppression of HSCs activation and liver fibrosis. - Highlights: • Alcohol increases intestinal bacterial overgrowth and permeability of endotoxin. • Endotoxin mediated inflammation plays a major role in alcoholic liver fibrosis. • Ascorbic acid reduces endotoxemia, NF-κB activation and proinflammatory cytokines. • AA's action is by inhibition of SIBO, IKKβ and alteration of

  14. FS&T Template

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    a Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000. This research is funded by WIPP programs administered by the Office of Environmental Management (EM) of the U.S Department of Energy. This research is funded by WIPP programs administered by the Office of Environmental

  15. Overview FS old.pdf

    Office of Environmental Management (EM)

    Energy Other EEOICP Links and Previous Federal Register Notices Other EEOICP Links and Previous Federal Register Notices Other EEOICP Links MOU between DOL and DOE MOU between HSS and DOE Tri-fold: Agencies Assisting with EEOIPA and the Former Worker Program Deputy Secretary Memo Regarnding Energy Emplyees Occupational Illness Compensation Program Act Interviews of Current and Former Workers Department of Labor Division of Energy Employees Occupational Illness Compensation National Institute

  16. Mangiferin exerts hepatoprotective activity against D-galactosamine induced acute toxicity and oxidative/nitrosative stress via Nrf2NF?B pathways

    SciTech Connect (OSTI)

    Das, Joydeep; Ghosh, Jyotirmoy; Roy, Anandita; Sil, Parames C.

    2012-04-01

    Mangiferin, a xanthone glucoside, is well known to exhibit antioxidant, antiviral, antitumor, anti-inflammatory and gene-regulatory effects. In the present study, we isolated mangiferin from the bark of Mangifera indica and assessed its beneficial role in galactosamine (GAL) induced hepatic pathophysiology. GAL (400 mg/kg body weight) exposed hepatotoxic rats showed elevation in the activities of serum ALP, ALT, levels of triglycerides, total cholesterol, lipid-peroxidation and reduction in the levels of serum total proteins, albumin and cellular GSH. Besides, GAL exposure (5 mM) in hepatocytes induced apoptosis and necrosis, increased ROS and NO production. Signal transduction studies showed that GAL exposure significantly increased the nuclear translocation of NF?B and elevated iNOS protein expression. The same exposure also elevated TNF-?, IFN-?, IL-1?, IL-6, IL-12, IL-18 and decreased IL-10 mRNA expressions. Furthermore, GAL also decreased the protein expression of Nrf2, NADPH:quinine oxidoreductase-1, heme oxygenase-1 and GST?. However, mangiferin administration in GAL intoxicated rats or coincubation of hepatocytes with mangiferin significantly altered all these GAL-induced adverse effects. In conclusion, the hepatoprotective role of mangiferin was due to induction of antioxidant defense via the Nrf2 pathway and reduction of inflammation via NF?B inhibition. Highlights: ?Galactosamine induces hepatocytes death via oxidative and nitrosative stress. ?Mangiferin exerts hepatoprotective effect/antioxidant defense via Nrf2 pathway. ?Mangiferin exerts anti-inflammatory responses by inhibiting NF-?B. ?Mangiferin suppresses galactosamine-induced repression of IL-10 mRNA.

  17. Celastrol ameliorates HIV-1 Tat-induced inflammatory responses via NF-kappaB and AP-1 inhibition and heme oxygenase-1 induction in astrocytes

    SciTech Connect (OSTI)

    Youn, Gi Soo; Kwon, Dong-Joo; Ju, Sung Mi; Rhim, Hyangshuk; Bae, Yong Soo; Choi, Soo Young; Park, Jinseu

    2014-10-01

    HIV-1 Tat causes extensive neuroinflammation that may progress to AIDS-related encephalitis and dementia. Celastrol possesses various biological activities such as anti-oxidant, anti-tumor, and anti-inflammatory activities. In this study, we investigated the modulatory effects of celastrol on HIV-1 Tat-induced inflammatory responses and the molecular mechanisms underlying its action in astrocytes. Pre-treatment of CRT-MG human astroglioma cells with celastrol significantly inhibited HIV-1 Tat-induced expression of ICAM-1/VCAM-1 and subsequent monocyte adhesiveness in CRT-MG cells. In addition, celastrol suppressed HIV-1 Tat-induced expression of pro-inflammatory chemokines, such as CXCL10, IL-8, and MCP-1. Celastrol decreased HIV-1 Tat-induced activation of JNK MAPK, AP-1, and NF-κB. Furthermore, celastrol induced mRNA and protein expression of HO-1 as well as Nrf2 activation. Blockage of HO-1 expression using siRNA reversed the inhibitory effect of celastrol on HIV-1 Tat-induced inflammatory responses. These results suggest that celastrol has regulatory effects on HIV-1 Tat-induced inflammatory responses by blocking the JNK MAPK-AP-1/NF-κB signaling pathways and inducing HO-1 expression in astrocytes. - Highlights: • Celastrol suppressed HIV-1 Tat-induced expression of pro-inflammatory genes. • Celastrol inhibited HIV-1 Tat -induced activation of JNK MAPK. • Celastrol inhibited HIV-1 Tat-induced activation of both NF-κB and AP-1. • Celastrol inhibited HIV-1 Tat-induced inflammatory responses via HO-1 induction.

  18. The plant limonoid 7-oxo-deacetoxygedunin inhibits RANKL-induced osteoclastogenesis by suppressing activation of the NF-{kappa}B and MAPK pathways

    SciTech Connect (OSTI)

    Wisutsitthiwong, Chonnaree; Buranaruk, Chayanit; Pudhom, Khanitha; Palaga, Tanapat

    2011-11-18

    Highlights: Black-Right-Pointing-Pointer A gedunin type limonoid from seeds of mangroves, 7-oxo-7-deacetoxygedunin, exhibits strong anti-osteoclastogenic activity. Black-Right-Pointing-Pointer Treatment with this limonoid results in significant decrease in expression of NFATc1 and osteoclast-related genes. Black-Right-Pointing-Pointer The mode of action of this limonoid is by inhibiting activation of the NF-{kappa}B and MAPK pathways which are activated by RANKL. -- Abstract: Osteoclasts together with osteoblasts play pivotal roles in bone remodeling. Aberrations in osteoclast differentiation and activity contribute to osteopenic disease. Osteoclasts differentiate from monocyte/macrophage progenitors, a process that is initiated by the interaction between receptor activator of NF-{kappa}B (RANK) and its ligand, RANKL. In this study, we identified 7-oxo-7-deacetoxygedunin (7-OG), a gedunin type limonoid from seeds of the mangrove Xylocarpus moluccensis, as a potent inhibitor of osteoclastogenesis. Additionally, 7-OG showed strong anti-osteoclastogenic activity with low cytotoxicity against the monocyte/macrophage progenitor cell line, RAW264.7. The IC50 for anti-osteoclastogenic activity was 4.14 {mu}M. Treatment with 7-OG completely abolished the appearance of multinucleated giant cells with tartrate-resistant acid phosphatase activity in RAW264.7 cells stimulated with RANKL. When the expression of genes related to osteoclastogenesis was investigated, a complete downregulation of NFATc1 and cathepsin K and a delayed downregulation of irf8 were observed upon 7-OG treatment in the presence of RANKL. Furthermore, treatment with this limonoid suppressed RANKL-induced activation of p38, MAPK and Erk and nuclear localization of NF-{kappa}B p65. Taken together, we present evidence indicating a plant limonoid as a novel osteoclastogenic inhibitor that could be used for osteoporosis and related conditions.

  19. Tat-CBR1 inhibits inflammatory responses through the suppressions of NF-κB and MAPK activation in macrophages and TPA-induced ear edema in mice

    SciTech Connect (OSTI)

    Kim, Young Nam; Kim, Dae Won; Jo, Hyo Sang; Shin, Min Jea; Ahn, Eun Hee; Ryu, Eun Ji; Yong, Ji In; Cha, Hyun Ju; Kim, Sang Jin; Yeo, Hyeon Ji; Youn, Jong Kyu; Hwang, Jae Hyeok; Jeong, Ji-Heon; Kim, Duk-Soo; Cho, Sung-Woo; Park, Jinseu; Eum, Won Sik; Choi, Soo Young

    2015-07-15

    Human carbonyl reductase 1 (CBR1) plays a crucial role in cell survival and protects against oxidative stress response. However, its anti-inflammatory effects are not yet clearly understood. In this study, we examined whether CBR1 protects against inflammatory responses in macrophages and mice using a Tat-CBR1 protein which is able to penetrate into cells. The results revealed that purified Tat-CBR1 protein efficiently transduced into Raw 264.7 cells and inhibited lipopolysaccharide (LPS)-induced cyclooxygenase-2 (COX-2), nitric oxide (NO) and prostaglandin E{sub 2} (PGE{sub 2}) expression levels. In addition, Tat-CBR1 protein leads to decreased pro-inflammatory cytokine expression through suppression of nuclear transcription factor-kappaB (NF-κB) and mitogen activated protein kinase (MAPK) activation. Furthermore, Tat-CBR1 protein inhibited inflammatory responses in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation when applied topically. These findings indicate that Tat-CBR1 protein has anti-inflammatory properties in vitro and in vivo through inhibition of NF-κB and MAPK activation, suggesting that Tat-CBR1 protein may have potential as a therapeutic agent against inflammatory diseases. - Highlights: • Transduced Tat-CBR1 reduces LPS-induced inflammatory mediators and cytokines. • Tat-CBR1 inhibits MAPK and NF-κB activation. • Tat-CBR1 ameliorates inflammation response in vitro and in vivo. • Tat-CBR1 may be useful as potential therapeutic agent for inflammation.

  20. HSF1 and NF-κB p65 participate in the process of exercise preconditioning attenuating pressure overload-induced pathological cardiac hypertrophy

    SciTech Connect (OSTI)

    Xu, Tongyi; Zhang, Ben; Yang, Fan; Cai, Chengliang; Wang, Guokun; Han, Qingqi; Zou, Liangjian

    2015-05-08

    Pathological cardiac hypertrophy, often accompanied by hypertension, aortic stenosis and valvular defects, is typically associated with myocyte remodeling and cardiac dysfunction. Exercise preconditioning (EP) has been proven to enhance the tolerance of the myocardium to cardiac ischemia-reperfusion injury. However, the effects of EP in pathological cardiac hypertrophy are rarely reported. 10-wk-old male Sprague–Dawley rats (n = 80) were randomly divided into four groups: sham, TAC, EP + sham and EP + TAC. Two EP groups were subjected to 4 weeks of treadmill training, and the EP + TAC and TAC groups were followed by TAC operations. The sham and EP + sham groups underwent the same operation without aortic constriction. Eight weeks after the surgery, we evaluated the effects of EP by echocardiography, morphology, and histology and observed the expressions of the associated proteins. Compared with the respective control groups, hypertrophy-related indicators were significantly increased in the TAC and EP + TAC groups (p < 0.05). However, between the TAC and EP + TAC groups, all of these changes were effectively inhibited by EP treatment (p < 0.05). Furthermore, EP treatment upregulated the expression of HSF1 and HSP70, increased the HSF1 levels in the nuclear fraction, inhibited the expression of the NF-κB p65 subunit, decreased the NF-κB p65 subunit levels in the nuclear fraction, and reduced the IL2 levels in the myocardia of rats. EP could effectively reduce the cardiac hypertrophic responses induced by TAC and may play a protective role by upregulating the expressions of HSF1 and HSP70, activating HSF1 and then inhibiting the expression of NF-κB p65 and nuclear translocation. - Highlights: • EP could effectively reduce the cardiac hypertrophic responses induced by TAC. • EP may play a protective role by upregulating the expressions of HSF1 and HSP70 and then activating HSF1. • EP may play a protective role by inhibiting the expression

  1. OSU-A9 inhibits angiogenesis in human umbilical vein endothelial cells via disrupting AktNF-?B and MAPK signaling pathways

    SciTech Connect (OSTI)

    Omar, Hany A.; Arafa, El-Shaimaa A.; Salama, Samir A.; Arab, Hany H.; Wu, Chieh-Hsi; Weng, Jing-Ru

    2013-11-01

    Since the introduction of angiogenesis as a useful target for cancer therapy, few agents have been approved for clinical use due to the rapid development of resistance. This problem can be minimized by simultaneous targeting of multiple angiogenesis signaling pathways, a potential strategy in cancer management known as polypharmacology. The current study aimed at exploring the anti-angiogenic activity of OSU-A9, an indole-3-carbinol-derived pleotropic agent that targets mainly Aktnuclear factor-kappa B (NF-?B) signaling which regulates many key players of angiogenesis such as vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs). Human umbilical vein endothelial cells (HUVECs) were used to study the in vitro anti-angiogenic effect of OSU-A9 on several key steps of angiogenesis. Results showed that OSU-A9 effectively inhibited cell proliferation and induced apoptosis and cell cycle arrest in HUVECs. Besides, OSU-A9 inhibited angiogenesis as evidenced by abrogation of migration/invasion and Matrigel tube formation in HUVECs and attenuation of the in vivo neovascularization in the chicken chorioallantoic membrane assay. Mechanistically, Western blot, RT-PCR and ELISA analyses showed the ability of OSU-A9 to inhibit MMP-2 production and VEGF expression induced by hypoxia or phorbol-12-myristyl-13-acetate. Furthermore, dual inhibition of AktNF-?B and mitogen-activated protein kinase (MAPK) signaling, the key regulators of angiogenesis, was observed. Together, the current study highlights evidences for the promising anti-angiogenic activity of OSU-A9, at least in part through the inhibition of AktNF-?B and MAPK signaling and their consequent inhibition of VEGF and MMP-2. These findings support OSU-A9's clinical promise as a component of anticancer therapy. - Highlights: The antiangiogenic activity of OSU-A9 in HUVECs was explored. OSU-A9 inhibited HUVECs proliferation, migration, invasion and tube formation. OSU-A9 targeted signaling

  2. NF_Eder_2013

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    ... and temperatures ranging from low-density hot plasmas to cold fragmenting solids. ... number and cost of optics 2 Nucl. Fusion 53 (2013) 113037 D.C. Eder et al and diagnostics. ...

  3. TGF-{beta}1 increases invasiveness of SW1990 cells through Rac1/ROS/NF-{kappa}B/IL-6/MMP-2

    SciTech Connect (OSTI)

    Binker, Marcelo G.; CBRHC Research Center, Buenos Aires ; Binker-Cosen, Andres A.; Gaisano, Herbert Y.; Cosen, Rodica H. de; Cosen-Binker, Laura I.

    2011-02-04

    Research highlights: {yields} Rac1 mediates TGF-{beta}1-induced SW1990 invasion through MMP-2 secretion and activation. {yields} NADPH-generated ROS act downstream of Rac1 in TGF-{beta}1-challenged SW1990 cells. {yields} TGF-{beta}1-stimulated ROS activate NF-{kappa}B in SW1990 cells. {yields} NF{kappa}B-induced IL-6 release is required for secretion and activation of MMP-2 in SW1990 cells. -- Abstract: Human pancreatic cancer invasion and metastasis have been found to correlate with increased levels of active matrix metalloproteinase 2 (MMP-2). The multifunctional cytokine transforming growth factor beta 1 (TGF-{beta}1) has been shown to increase both secretion of MMP-2 and invasion by several pancreatic cancer cell types. In the present study, we investigated the signaling pathway involved in TGF-{beta}1-promoted MMP-2 secretion and invasion by human pancreatic cancer cells SW1990. Using specific inhibitors, we found that stimulation of these tumor cells with TGF-{beta}1 induced secretion and activation of the collagenase MMP-2, which was required for TGF-{beta}1-stimulated invasion. Our results also indicate that signaling events involved in TGF-{beta}1-enhanced SW1990 invasiveness comprehend activation of Rac1 followed by generation of reactive oxygen species through nicotinamide adenine dinucleotide phosphate-oxidase, activation of nuclear factor-kappa beta, release of interleukin-6, and secretion and activation of MMP-2.

  4. Cyanidin-3-glucoside inhibits UVB-induced oxidative damage and inflammation by regulating MAP kinase and NF-κB signaling pathways in SKH-1 hairless mice skin

    SciTech Connect (OSTI)

    Pratheeshkumar, Poyil; Son, Young-Ok; Wang, Xin; Divya, Sasidharan Padmaja; Joseph, Binoy; Hitron, John Andrew; Wang, Lei; Kim, Donghern; Yin, Yuanqin; Roy, Ram Vinod; Lu, Jian; Zhang, Zhuo; Wang, Yitao; and others

    2014-10-01

    Skin cancer is one of the most commonly diagnosed cancers in the United States. Exposure to ultraviolet-B (UVB) radiation induces inflammation and photocarcinogenesis in mammalian skin. Cyanidin-3-glucoside (C3G), a member of the anthocyanin family, is present in various vegetables and fruits especially in edible berries, and displays potent antioxidant and anticarcinogenic properties. In this study, we have assessed the in vivo effects of C3G on UVB irradiation induced chronic inflammatory responses in SKH-1 hairless mice, a well-established model for UVB-induced skin carcinogenesis. Here, we show that C3G inhibited UVB-induced skin damage and inflammation in SKH-1 hairless mice. Our results indicate that C3G inhibited glutathione depletion, lipid peroxidation and myeloperoxidation in mouse skin by chronic UVB exposure. C3G significantly decreased the production of UVB-induced pro-inflammatory cytokines, such as IL-6 and TNF-α, associated with cutaneous inflammation. Likewise, UVB-induced inflammatory responses were diminished by C3G as observed by a remarkable reduction in the levels of phosphorylated MAP kinases, Erk1/2, p38, JNK1/2 and MKK4. Furthermore, C3G also decreased UVB-induced cyclooxygenase-2 (COX-2), PGE{sub 2} and iNOS levels, which are well-known key mediators of inflammation and cancer. Treatment with C3G inhibited UVB-induced nuclear translocation of NF-κB and degradation of IκBα in mice skin. Immunofluorescence assay revealed that topical application of C3G inhibited the expression of 8-hydroxy-2′-deoxyguanosine, proliferating cell nuclear antigen, and cyclin D1 in chronic UVB exposed mouse skin. Collectively, these data indicates that C3G can provide substantial protection against the adverse effects of UVB radiation by modulating UVB-induced MAP kinase and NF-κB signaling pathways. - Highlights: • C3G inhibited UVB-induced oxidative damage and inflammation. • C3G inhibited UVB-induced COX-2, iNOS and PGE{sub 2} production. • C3G

  5. Estimated (n,f) cross sections for 236,236m237,238-Np, 237,237m-Pu, and 240,241,242,242m,243,244,244m-Am isotopes

    SciTech Connect (OSTI)

    Younes, W; Becker, J; Britt, H

    2004-01-16

    Neutron-induced fission cross sections on targets of {sup 236,236m,237,238}Np, {sup 237,237m}Pu, and {sup 240,241,242,242m,243,244,244m}Am have been estimated for incident neutron energies of up to 6 MeV, using the ''surrogate'' technique and the ({sup 3}He,df) and ({sup 3}He,tf) reactions on stable targets to measure fission probabilities. In isotopes where low-lying isomeric states are known to exist, the (n,f) cross section on the corresponding isomeric targets has been estimated, using the surrogate technique. For targets of {sup 237}Np, {sup 241}Am, {sup 242m}Am, {sup 243}Am, measurements of the (n,f) cross section exist, and comparison with the surrogate-method results suggests that the (n,f) cross sections estimated by the surrogate technique are reliable to within 10% for incident neutron energies E{sub n}{approx}>2 MeV. Tabulated values of the estimated (n,f) cross sections are given in an appendix.

  6. miR-15a/16 Enhances Radiation Sensitivity of Non-Small Cell Lung Cancer Cells by Targeting the TLR1/NF-κB Signaling Pathway

    SciTech Connect (OSTI)

    Lan, Fengming; Yue, Xiao; Ren, Gang; Li, Hongqi; Ping, Li; Wang, Yingjie; Xia, Tingyi

    2015-01-01

    Purpose: Many miRNAs have been identified as essential issues and core determining factors in tumor radiation. Recent reports have demonstrated that miRNAs and Toll-like receptors could exert reciprocal effects to control cancer development in various ways. However, a novel role of miR-15a/16 in enhancing radiation sensitivity by directly targeting TLR1 has not been reported, to our knowledge. Methods and Materials: Bioinformatic analyses, luciferase reporter assay, biochemical assays, and subcutaneous tumor establishment were used to characterize the signaling pathways of miRNA-15a/16 in response to radiation treatment. Results: First, an inverse correlation between the expression of miR-15a/16 and TLR1 protein was revealed in non-small cell lung cancer (NSCLC) and normal lung tissues. Next, we corroborated that miR-15a/16 specifically bound to TLR1 3′UTR and inhibited the expression of TLR1 in H358 and A549 cells. Furthermore, miR-15a/16 downregulated the activity of the NF-κB signaling pathway through TLR1. In addition, overexpression of miR-15a/16 inhibited survival capability and increased radiation-induced apoptosis, resulting in enhancement of radiosensitivity in H358 and A549 cells. Finally, subcutaneous tumor bearing NSCLC cells in a nude mice model was established, and the results showed that combined groups (miR-15a/16 + radiation) inhibited tumor growth more significantly than did radiation alone. Conclusions: We mainly elucidate that miRNA-15a/16 can enhance radiation sensitivity by regulating the TLR1/NF-κB signaling pathway and act as a potential therapeutic approach to overcome radioresistance for lung cancer treatment.

  7. The (3He,tf) as a surrogate reaction to determine (n,f) cross sections in the 10 to 20 MeV energy range

    SciTech Connect (OSTI)

    Basunia, M. S.; Clark, R. M.; Goldblum, B. L.; Bernstein, L. A.; Phair, L.; Burke, J. T.; Beausang, C. W.; Bleuel, D. L.; Darakchieva, B.; Dietrich, F. S.; Evtimova, M.; Fallon, P.; Gibelin, J.; Hatarik, R.; Jewett, C. C.; Lesher, S. R.; McMahan, M. A.; Rodriguez-Vieitez, E.; Wiedeking, M.

    2009-02-25

    The surrogate reaction 238U(3He,tf) is used to determine the 237Np(n,f) cross section indirectly over an equivalent neutron energy range from 10 to 20 MeV. A self-supporting ~;;761 mu g/cm2 metallic 238U foil was bombarded with a 42 MeV 3He2+ beam from the 88-Inch Cyclotron at Lawrence Berkeley National Laboratory (LBNL). Outgoing charged particles and fission fragments were identified using the Silicon Telescope Array for Reaction Studies (STARS), consists of two 140 mu m and one 1000 mu m Micron S2 type silicon detectors. The 237Np(n,f) cross sections, determined indirectly, were compared with the 237Np(n,f) cross section data from direct measurements, the Evaluated Nuclear Data File (ENDF/B-VII.0), and the Japanese Evaluated Nuclear Data Library (JENDL 3.3) and found to closely follow those datasets. Use of the (3He,tf) reaction as a surrogate to extract (n,f) cross section in the 10 to 20 MeV equivalent neutron energy is found to be suitable.

  8. Dietary turmeric modulates DMBA-induced p21{sup ras}, MAP kinases and AP-1/NF-{kappa}B pathway to alter cellular responses during hamster buccal pouch carcinogenesis

    SciTech Connect (OSTI)

    Garg, Rachana; Ingle, Arvind; Maru, Girish

    2008-11-01

    The chemopreventive efficacy of turmeric has been established in experimental systems. However, its mechanism(s) of action are not fully elucidated in vivo. The present study investigates the mechanism of turmeric-mediated chemoprevention in 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis at 2, 4, 6, 10 and 12 weeks. Dietary turmeric (1%) led to decrease in DMBA-induced tumor burden and multiplicity, and enhanced the latency period in parallel, to its modulatory effects on oncogene products and various cellular responses during HBP tumorigenesis. DMBA-induced expression of ras oncogene product, p21 and downstream target, the mitogen-activated protein kinases were significantly decreased by turmeric during HBP carcinogenesis. Turmeric also diminished the DMBA-induced mRNA expression of proto-oncogenes (c-jun, c-fos) and NF-{kappa}B, leading to decreased protein levels and in further attenuation of DMBA-induced AP-1/NF-{kappa}B DNA-binding in the buccal pouch nuclear extracts. Besides, buccal pouch of hamsters receiving turmeric diet showed significant alterations in DMBA-induced effects: (a) decrease in cell proliferation (diminished PCNA and Bcl2 expression), (b) enhanced apoptosis (increased expression of Bax, caspase-3 and apoptotic index), (c) decrease in inflammation (levels of Cox-2, the downstream target of AP-1/NF-{kappa}B, and PGE2) and (d) aberrant expression of differentiation markers, the cytokeratins (1, 5, 8, and 18). Together, the protective effects of dietary turmeric converge on augmenting apoptosis of the initiated cells and decreasing cell proliferation in DMBA-treated animals, which in turn, is reflected in decreased tumor burden, multiplicity and enhanced latency period. Some of these biomarkers are likely to be helpful in monitoring clinical trials and evaluating drug effect measurements.

  9. DOE/EIS-0005-FS-2

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ... Indian Affairs; Bureau of Land Management; Fish and Wildlife Service; and Geological ... The U . S . Fish and Wildli fe Service and several state agenc ies al so manage land in ...

  10. oetd_fs_trp1.indd

    Office of Environmental Management (EM)

    computation of grid status and electricity market pricing. Load as a Resource This activity evaluates the capability of load to respond to price signals to improve grid ...

  11. Microsoft Word - CERCLA FS-final.doc

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    ... The 200-UP-1 Groundwater Operable Unit has a pump- and-treat system to remove uranium and ... University of Washington Branford Price and Miller Library Suzzallo Library 934 SW ...

  12. Mercury Ban Sum FS.pdf

    Office of Environmental Management (EM)

    Buckman Direct Diversion Board Regarding Water Quality Monitoring and Surface Water Protection | Department of Energy Memorandums of Understanding Between the Department of Energy and the Buckman Direct Diversion Board Regarding Water Quality Monitoring and Surface Water Protection Memorandums of Understanding Between the Department of Energy and the Buckman Direct Diversion Board Regarding Water Quality Monitoring and Surface Water Protection Topic: Cheryl Rodriguez, DOE and Steve Veenis,

  13. DOE/ EIS-0050-FS Final Environmentl Impact

    Energy.gov (indexed) [DOE]

    (STAR); and publication, NTIS-PR-360 available from (NTIS) at the above address. UNITED STATES DEPARTMENT OF ENERGY WASHINGTON, D.C. 2055 OFFICIAL BUSINESS PENAL TY FOR PRIVATE...

  14. Microsoft Word - Final FS ROD.doc

    National Nuclear Security Administration (NNSA)

    ... of renewable resources such as wind, solar, and geothermal in the West (Black & ... systems may diminish the need for some future long- distance transmission, current ...

  15. The REMOTE SENSlNf

    Office of Legacy Management (LM)

    ... Louis, MO Remedial Action Projects Ashland Oil, Tonawanda, NY (sites I and II) Seaway ... Gamma Ray Spectrometry. HASL-258. (United States Atomic Energy CornmIssIon, Health and ...

  16. Knockdown of hepatoma-derived growth factor-related protein-3 induces apoptosis of H1299 cells via ROS-dependent and p53-independent NF-κB activation

    SciTech Connect (OSTI)

    Yun, Hong Shik; Baek, Jeong-Hwa; Yim, Ji-Hye; Lee, Su-Jae; Lee, Chang-Woo; Song, Jie-Young; Um, Hong-Duck; Park, Jong Kuk; Park, In-Chul; Hwang, Sang-Gu

    2014-07-11

    Highlights: • HRP-3 is a radiation- and anticancer drug-responsive protein in H1299 cells. • Depletion of HRP-3 induces apoptosis of radio- and chemoresistant H1299 cells. • Depletion of HRP-3 promotes ROS generation via inhibition of the Nrf2/HO-1 pathway. • ROS generation enhances NF-κB activity, which acts as an upstream signal in the c-Myc/Noxa apoptotic pathway. - Abstract: We previously identified hepatoma-derived growth factor-related protein-3 (HRP-3) as a radioresistant biomarker in p53 wild-type A549 cells and found that p53-dependent induction of the PUMA pathway was a critical event in regulating the radioresistant phenotype. Here, we found that HRP-3 knockdown regulates the radioresistance of p53-null H1299 cells through a distinctly different molecular mechanism. HRP-3 depletion was sufficient to cause apoptosis of H1299 cells by generating substantial levels of reactive oxygen species (ROS) through inhibition of the Nrf2/HO-1 antioxidant pathway. Subsequent, ROS-dependent and p53-independent NF-κB activation stimulated expression of c-Myc and Noxa proteins, thereby inducing the apoptotic machinery. Our results thus extend the range of targets for the development of new drugs to treat both p53 wild-type or p53-null radioresistant lung cancer cells.

  17. Eu{sub 3}F{sub 4}S{sub 2}: Synthesis, crystal structure, and magnetic properties of the mixed-valent europium(II,III) fluoride sulfide EuF{sub 2}.(EuFS){sub 2}

    SciTech Connect (OSTI)

    Grossholz, Hagen; Hartenbach, Ingo; Kotzyba, Gunter; Poettgen, Rainer; Trill, Henning; Mosel, Bernd D.; Schleid, Thomas

    2009-11-15

    Using the method to synthesize rare-earth metal(III) fluoride sulfides MFS (M=Y, La, Ce-Lu), in some cases we were able to obtain mixed-valent compounds such as Yb{sub 3}F{sub 4}S{sub 2} instead. With Eu{sub 3}F{sub 4}S{sub 2} another isotypic representative has now been synthesized. Eu{sub 3}F{sub 4}S{sub 2} (tetragonal, I4/mmm, a=400.34(2), c=1928.17(9) pm, Z=2) is obtained from the reaction of metallic europium, elemental sulfur, and europium trifluoride in a molar ratio of 5:6:4 within seven days at 850 deg. C in silica-jacketed gas-tightly sealed platinum ampoules. The single-phase product consists of black plate-shaped single crystals with a square cross section, which can be obtained from a flux using equimolar amounts of NaCl as fluxing agent. The crystal structure is best described as an intergrowth structure, in which one layer of CaF{sub 2}-type EuF{sub 2} is followed by two layers of PbFCl-type EuFS when sheeted parallel to the (001) plane. Accordingly there are two chemically and crystallographically different europium cations present. One of them (Eu{sup 2+}) is coordinated by eight fluoride anions in a cubic fashion, the other one (Eu{sup 3+}) exhibits a monocapped square antiprismatic coordination sphere with four F{sup -} and five S{sup 2-} anions. Although the structural ordering of the different charged europium cations is plausible, a certain amount of charge delocalization with some polaron activity has to take place, which is suggested by the black color of the title compound. Temperature dependent magnetic susceptibility measurements of Eu{sub 3}F{sub 4}S{sub 2} show Curie-Weiss behavior with an experimental magnetic moment of 8.19(5) mu{sub B} per formula unit and a paramagnetic Curie temperature of 0.3(2) K. No magnetic ordering is observed down to 4.2 K. In accordance with an ionic formula splitting like (Eu{sup II})(Eu{sup III}){sub 2}F{sub 4}S{sub 2} only one third of the europium centers in Eu{sub 3}F{sub 4}S{sub 2} carry permanent

  18. SimFS: A Large Scale Parallel File System Simulator

    Energy Science and Technology Software Center (OSTI)

    2011-08-30

    The software provides both framework and tools to simulate a large-scale parallel file system such as Lustre.

  19. Hybrid fs/ps Rotational CARS Temperature and Concentration Measurement...

    Office of Scientific and Technical Information (OSTI)

    Hybrid fsps Rotational CARS Temperature and Concentration Measurements Using Two Different ps-Duration Probe Beams. Citation Details In-Document Search Title: Hybrid fsps ...

  20. EIS-0005-FS: Draft Supplemental Environmental Impact Statement

    Energy.gov [DOE]

    Bonneville Power Administration Proposed FY 1979 Program, Facility Location on Supplement, Southwest Oregon Area Service, Buckley-Summer Lake 500 kV Line, Supplemental

  1. Audit Report: ER-FS-99-01

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    is to inform Chicago Operations Office management concerning matters that came to the attention of the Office of Inspector General during the audit at the Chicago Operations...

  2. file://\\fs-f1\shared\uranium\uranium.html

    U.S. Energy Information Administration (EIA) (indexed site)

    Glossary Home > Nuclear > U.S. Uranium Reserves Estimates U.S. Uranium Reserves Estimates Data for: 2008 Report Released: July 2010 Next Release Date: 2012 Summary The U.S. Energy Information Administration (EIA) has updated its estimates of uranium reserves for year-end 2008. This represents the first revision of the estimates since 2004. The update is based on analysis of company annual reports, any additional information reported by companies at conferences and in news releases,

  3. Microsoft Word - 25788WDC_DOE DD FS.docx

    Energy Savers

    June 14, 2011 REPLY TO ATTN OF: IG-35 (A10FN003) SUBJECT: Uranium Enrichment ... the United States Department of Energy's Uranium Enrichment Decontamination and ...

  4. Audit Report: WR-FS-97-04

    Energy.gov [DOE]

    Report on Matters Identified at the Richland Operations Office During the Audit of the Department's Consolidated Fiscal Year 1996 Financial Statements

  5. Audit report: ER-FS-99-02

    Energy.gov [DOE]

    Matters Identified At The Oak Ridge Operations Office During the Audit Of The Department's Consolidated Fiscal Year 1998 Financial Statements

  6. Audit Report: WR-FS-97-03

    Energy.gov [DOE]

    Report on Matters Identified at the Rocky Flats Field Office During the Audit of the Department's Consolidated Fiscal Year 1996 Financial Statements

  7. Audit Report: OAS-FS-09-06

    Energy.gov [DOE]

    Uranium Enrichment Decontamination and Decommissioning Fund's Fiscal Year 2006 and 2005 Financial Statement Audit

  8. EIS-0005-FS: Final Supplemental Environmental Impact Statement

    Office of Energy Efficiency and Renewable Energy (EERE)

    Bonneville Power Administration Proposed FY 1979 Program, Facility Location on Supplement, Southwest Oregon Area Service, Buckley-Summer Lake 500 kV Line, Supplemental

  9. Financial Statement: WR-FS-00-02

    Energy.gov [DOE]

    Report on Matters Identified at The Idaho Operations Office During The Audit of The Department of Energy's Consolidated Fiscal Year 1999 Financial Statements

  10. Audit Report: WR-FS-99-04

    Energy.gov [DOE]

    Matters Identified at the Oakland Operations Office During the Audit of the Department of Energy's Consolidated Fiscal Year 1998 Financial Statements

  11. Audit Report: WR-FS-99-03

    Energy.gov [DOE]

    Matters Identified at the Richland Operations Office During the Audit of the Department of Energy's Consolidated Fiscal Year 1998 Financial Statements

  12. Finanacial Statement: WR-FS-99-02

    Energy.gov [DOE]

    Report on Matters Identified at the Albuquerque Operations Office During the Audit of the Department of Energy's Consolidated Fiscal Year 1998 Financial Statements

  13. Financial Statement: WR-FS-00-01

    Energy.gov [DOE]

    Report on Matters Identified at The Hanford Site during the Audit of The Department of Energy's Consolidated Fiscal year 1999 Financial Statements

  14. Finanacial Statement: WR-FS-09-03

    Energy.gov [DOE]

    Report on Matters Identified at the Richland Operations Office during the Audit of The Department of Energy's Consolidated Fiscal Year 1998 Financial Statements

  15. Audit Report: ER-FS-99-01

    Energy.gov [DOE]

    Results of Audit Procedures Performed at Chicago Operations Office During the Audit of the Department’s Consolidated Fiscal Year 1998 Financial Statements

  16. Audit Report: ER-FS-99-03

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    S. DEPARTMENT OF ENERGY OFFICE OF INSPECTOR GENERAL MATTERS IDENTIFIED AT THE SAVANNAH RIVER OPERATIONS OFFICE DURING THE AUDIT OF THE DEPARTMENT'S CONSOLIDATED FISCAL YEAR 1998 FINANCIAL STATEMENTS The office of Inspector General wants to make the distribution of its reports as customer friendly and cost effective as possible. Therefore, this report will be available electronically through the Internet at the following addresses: Department of Energy Management and Administration Home Page

  17. Audit Report: ER-FS-99-04

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    (8-89) EFG (07-90) United States Government Department of Energy Memorandum INTRODUCTION AND OBJECTIVE The Government Management Reform Act of 1994 requires that audited financial statements covering all accounts and associated activities of the Department be submitted annually to the Office of Management and Budget. A Departmentwide audit of the consolidated Fiscal Year 1998 financial statements was conducted by examining internal controls, assessing compliance with laws and regulations,

  18. EIS-0005-FS-2: Final Environmental Impact Statement

    Energy.gov [DOE]

    Bonneville Power Administration Proposed FY 1979 Program Facility Planning Supplement Southwest Oregon Area Service, Supplemental

  19. Microsoft Word - Final Report Package Transmittal - FY 2010 FS...

    Energy Savers

    Assistant Secretary for Nuclear Energy, NE-1 Director, ... Secretary for Environmental Management, EM-1 Principal Deputy ... of Health, Safety and Security, HS-1 Deputy Director ...

  20. Microsoft Word - ATLAS WS 2014 FS report fnl

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    ... First coincidence data from laser-trapped 6 He has been observed and higher statistics ... ( 19 Ne, 35 Ar) and alkali and alkaline earth atoms that can be produced in abundance ...

  1. Audit Report: OAS-FS-13-01 | Department of Energy

    Energy Savers

    2 Audit Report: OAI-M-16-12 June 23, 2016 Management of Infrastructure at the Pantex Plant The National Nuclear Security Administration's (NNSA) Pantex Plant mission includes the manufacture of specialty explosives, fabrication, and testing of high explosive components, pit requalification and surveillance, and other activities. The NNSA Production Office has the oversight responsibility for the work performed by Consolidated Nuclear Security LLC, the management and operating contractor at

  2. Streamlined RI/FS planning for the groundwater operable unit at the Weldon Spring Site

    SciTech Connect (OSTI)

    Picel, M.H.; Durham, L.A.; Blunt, D.L.; Hartmann, H.M.

    1995-12-31

    The U.S. Department of Energy (DOE) is conducting cleanup activities at the chemical plant area of the Weldon Spring Site located in St. Charles County, Missouri, about 48 km (30 mi) west of St. Louis and 22 km (14 mi) southwest of the City of St. Charles. The 88-ha (217-acre) chemical plant area is chemically and radioactively contaminated as a result of uranium processing activities conducted by the U.S. Atomic Energy Commission during the 1950s and 1960s. The Army also used the chemical plant area for the production of explosives in the 1940s. The Weldon Spring Site chemical plant area was listed on the National Priorities List (NPL) in 1989. Adjacent to the chemical plant area is another NPL site known as the Weldon Spring Ordnance Works. The ordnance works area is a former explosive production facility that manufactured trinitrotoluene (TNT) and dinitrotoluene (DNT) during World War II. The ordnance works area covers 7,000 ha (17,232 acres); cleanup of this site is managed by the U.S. Army Corps of Engineers (CE).

  3. Portsmouth RI/FS Report for the Process Buildings and Complex...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Portsmouth RIFS Report for the Process Buildings and Complex Facilities Decontamination and Decommissioning Evaluation Project This remedial investigationfeasibility study (RIFS...

  4. Portsmouth RI/FS Report for the Site-Wide Waste Disposition Evaluation...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Site-Wide Waste Disposition Evaluation Project Portsmouth RIFS Report for the Site-Wide ... RIFS Report for the Site-Wide Waste Disposition Evaluation Project for Portsmouth incl. ...

  5. Audit Report: OAS-FS-10-06 | Department of Energy

    Energy Savers

    7 Audit Report: IG-0837 August 10, 2010 Nuclear Safety: Safety Basis and Quality Assurance at the Los Alamos National Laboratory The Department of Energy's Los Alamos National Laboratory is a government-owned, contractor-operated facility that is part of the National Nuclear Security Administration's (NNSA) nuclear weapons complex. Los Alamos' primary mission is to ensure the safety, security and reliability of the Nation's nuclear deterrent force. To meet its mission, Los Alamos employees and

  6. Audit Report: OAS-FS-13-03 | Department of Energy

    Energy.gov (indexed) [DOE]

    The Federal Energy Regulatory Commission's Fiscal Year 2012 Financial Statement Audit KPMG, LLP concluded that the financial statements present fairly, in all material respects,...

  7. DOE-EIS-0245-FS-SA2_August_2001.pdf

    U.S. Department of Energy (DOE) all webpages (Extended Search)

  8. Audit Report: OAS-FS-12-10 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    with the independent public accounting firm of KPMG, LLP (KPMG) to audit the combined balance sheets of the Southwestern Federal Power System (SWFPS) as of September 30, 2010 and...

  9. Audit Report: OAS-FS-13-05 | Department of Energy

    Office of Environmental Management (EM)

    (KPMG) audited the Department of Energy's Nuclear Waste Fund's (Fund) Fiscal Year 2012 balance sheet and the related statements of net cost, changes in net position and budgetary...

  10. Audit Report: OAS-FS-08-04 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Technology Management Letter on the Audit of the Department of Energy's Consolidated Balance Sheet for Fiscal Year 2007 Not Available for Viewing More Documents & Publications...

  11. Audit Report: OAS-FS-09-03 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Technology Management Letter on the Audit of the Department of Energy's Consolidated Balance Sheet for Fiscal Year 2008 Not Available for Viewing More Documents & Publications...

  12. Audit Report: OAS-FS-09-02 | Department of Energy

    Energy.gov (indexed) [DOE]

    presents the results of the independent certified public accoutants' audit of the Federal Energy Regulatory Commission (Commission) Fiscal Year 2008 and 2007 balance sheet and the...

  13. Interpreting, correlating, and predicting the multimedia concentrations of PCDD/Fs in the United Kingdom

    SciTech Connect (OSTI)

    Cole, J.G.; Mackay, D.; Jones, K.C.; Alcock, R.E.

    1999-02-01

    Reported concentrated of 17 polychlorinated dibenzo-p-dioxin and furan congeners or congener groups in ten environmental media of the UK have been compiled. The relative equilibrium status of each congener is deduced with respect to its concentration in urban air which is regarded as the primary source of multimedia contamination. This is accomplished by calculating the equilibrium lipid partitioning (ELP) concentration for each congener and medium using partitioning information derived from measured physical chemical properties. It is shown that the extents of departure from equilibrium conditions between media are consistent for all congeners except the octa-chlorinated compounds. This method of analyzing monitoring data and the consistency of intermedia ELP concentration ratios facilitates the interpretation of the fate and levels of these persistent chemicals in a multimedia environment and yields an approximate predictive capability by which levels in one medium can be used to estimate levels in other media. Benefits of this ELP concentration approach are discussed as a means of enhancing the more complete and detailed interpretation of monitoring data for persistent compounds.

  14. USDA-FS-EA-NV-030-06-025 2007 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Document Date 20070417 Relevant Numbers Lead Agency Doc Number EA-NV-030-06-025 Serial Number NVN-088208 Proposed Action See US Department of Agriculture Forest Service...

  15. USDA-FS-EA-NV-030-06-025 2012 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Document Date 20120216 Relevant Numbers Lead Agency Doc Number EA-NV-030-06-025 Serial Number NVN-088208 Proposed Action See US Department of Agriculture Forest Service...

  16. http://www.fs.fed.us/sopa/state-level.php?nv

    National Nuclear Security Administration (NNSA)

    Forest Service Schedule of Proposed Actions - Nevada Please use the map or drop-down lists to view the schedule for a particular National Forest, Grassland, Scenic Area, Recreation...

  17. A nitrogen-hyperdoped silicon material formed by femtosecond laser irradiation

    SciTech Connect (OSTI)

    Dong, Xiao; Zhu, Zhen; Shao, Hezhu; Rong, Ximing; Zhuang, Jun; Li, Ning; Liang, Cong; Sun, Haibin; Zhao, Li; Feng, Guojin

    2014-03-03

    A supersaturation of nitrogen atoms is found in the surface layer of microstructured silicon after femtosecond (fs) laser irradiation in NF{sub 3}. The average nitrogen concentration in the uppermost 50 nm is about 0.5 ± 0.2 at. %, several orders of magnitude higher than the solid solubility of nitrogen atoms in silicon. The nitrogen-hyperdoped silicon shows high crystallinity in the doped layer, which is due to the repairing effect of nitrogen on defects in silicon lattices. Nitrogen atoms and vacancies can be combined into thermal stable complexes after fs laser irradiation, which makes the nitrogen-hyperdoped silicon exhibit good thermal stability of optical properties.

  18. Data Package of Samples Collected for Hydrogeologic and Geochemical Characterization: 300 Area RI/FS Sediment Cores

    SciTech Connect (OSTI)

    Lindberg, Michael J.; Bjornstad, Bruce N.; Lanigan, David C.; Williams, Benjamin D.

    2011-05-01

    This is a data package for sediment samples received from the 300 FF 5 OU. This report was prepared for CHPRC. Between August 16, 2010 and April 25, 2011 sediment samples were received from 300-FF-5 for geochemical studies. The analyses for this project were performed at the 331 building located in the 300 Area of the Hanford Site. The analyses were performed according to Pacific Northwest National Laboratory (PNNL) approved procedures and/or nationally recognized test procedures. The data sets include the sample identification numbers, analytical results, estimated quantification limits (EQL), and quality control data. The preparatory and analytical quality control requirements, calibration requirements, acceptance criteria, and failure actions are defined in the on-line QA plan 'Conducting Analytical Work in Support of Regulatory Programs' (CAW). This QA plan implements the Hanford Analytical Services Quality Assurance Requirements Documents (HASQARD) for PNNL.

  19. VERIFICATION SURVEY ACTIVITIES IN FS SURVEY UNITS 7, 8, 9, 10, 11, 13 & 14 AT THE SEPARATIONS PROCESS RESEARCH UNIT

    SciTech Connect (OSTI)

    M.G. JADICK

    2010-05-26

    FINAL INTERIM REPORT VERIFICATION SURVEY ACTIVITIES IN FINAL STATUS SURVEY UNITS 7, 8, 9, 10, 11, 13 AND 14 AT THE SEPARATIONS PROCESS RESEARCH UNIT, Niskayuna, New York 0496-SR-03-0. The Separations Process Research Unit (SPRU) facilities were constructed in the late 1940s to research the chemical separation of plutonium and uranium. SPRU operated between February 1950 and October 1953. The research activities ceased following the successful development of the reduction/oxidation and plutonium/uranium extraction processes that were subsequently used by the Hanford and the Savannah River sites.

  20. http://www.fs.usda.gov/wps/portal/fsinternet/!ut/p/c5/04_SB8K8x

    National Nuclear Security Administration (NNSA)

    "Don't Trash Nevada" Pledge? Recent News Subscribe to this feed Correction to Aurora Geothermal Release Dated May 4, 20M VEB6FWOPOOW6 2011 Bridgeport and Carson Ranger Districts...

  1. 1.1-J, 120-fs laser system based on Nd:glass-pumped Ti:sapphire

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    ... For a fixed grating size, a smaller laser beam will experience less spectral clipping but will have a higher f luence and may damage the compressor gratings. Because current ...

  2. Audit of Departmental Integrated Standardized Core Accounting System (DISCAS) Operations at Selected Field Sites, AP-FS-97-02

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    AUDIT OF DEPARTMENTAL INTEGRATED STANDARDIZED CORE ACCOUNTING SYSTEM (DISCAS) OPERATIONS AT SELECTED FIELD SITES The Office of Inspector General wants to make the distribution of its reports as customer friendly and cost effective as possible. Therefore, this report will be available electronically through the Internet five to seven days after publication at the following alternative addresses: Department of Energy Headquarters Gopher gopher.hr.doe.gov Department of Energy Headquarters

  3. Materials Data on TiH12(NF2)4 (SG:56) by Materials Project

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Kristin Persson

    2014-11-02

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  4. Materials Data on Ca2NF (SG:141) by Materials Project

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Kristin Persson

    2014-11-02

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  5. Materials Data on Pr3NF6 (SG:1) by Materials Project

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Kristin Persson

    2014-11-02

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  6. Materials Data on H5NF2 (SG:53) by Materials Project

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Kristin Persson

    2014-11-02

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  7. Results of radiological measurements taken in the Niagara Falls, New York, area (NF002)

    SciTech Connect (OSTI)

    Williams, J.K.; Berven, B.A.

    1986-11-01

    The results of a radiological survey of 100 elevated gamma radiation anomalies in the Niagara Falls, New York, area are presented. These radiation anomalies were identified by a mobile gamma scanning survey during the period October 3-16, 1984, and were recommended for an onsite survey to determine if the elevated levels of radiation may be related to the transportation of radioactive waste material to the Lake Ontario Ordnance Works for storage. In this survey, radiological measurements included outdoor gamma exposure rates at 1 m above the surface; outdoor gamma exposure rates at the surface, range of gamma exposure rates during scan; and uranium, radium, and thorium concentrations in biased surface soil samples. The results show 38 anomalies (35 located along Pletcher Road and 3 associated with other unreleated locations) were found to exceed Formerly Utilized Sites Remedial Action Program (FUSRAP) remedial action guidelines and were recommended for formal characterization surveys. (Since the time of this survey, remedial actions have been conducted on the 38 anomalies identified as exceeding FUSRAP guidelines, and the radioactive material above guidelines has been removed.) The remaining 62 anomalies are associated with asphalt driveways and parking lots, which used a phosphate slag material (previously identified as cyclowollastonite, synthetic CaSiO/sub 3/). This rocky-slag waste material was used for bedding under asphalt surfaces and in general gravel applications. Most of the contaminated soil and rock samples collected at the latter anomalies had approximately equal concentrations of /sup 226/Ra and /sup 238/U and, therefore, are not related to materials connected with the Niagara Falls Storage Site (NFSS), including material that was transported to the NFSS. 13 refs., 7 figs., 14 tabs.

  8. Suppression of NF-κB signaling and NLRP3 inflammasome activation...

    Office of Scientific and Technical Information (OSTI)

    ... Resource Type: Journal Article Resource Relation: Journal Name: Toxicology and Applied Pharmacology; Journal Volume: 281; Journal Issue: 1; Other Information: Copyright (c) 2014 ...

  9. Nucleon, $$\\Delta$$ and $$\\Omega$$ excited states in $N_f=2+1$ lattice QCD

    DOE PAGES-Beta [OSTI]

    John Bulava; Edwards, Robert G.; Engelson, Eric; Joo, Balint; Lin, Huey -Wen; Morningstar, Colin; Richards, David G.; Wallace, Stephen J.

    2010-07-22

    The energies of the excited states of the Nucleon,more » $$\\Delta$$ and $$\\Omega$$ are computed in lattice QCD, using two light quarks and one strange quark on anisotropic lattices. The calculation is performed at three values of the light quark mass, corresponding to pion masses $$m_{\\pi}$$ = 392(4), 438(3) and 521(3) MeV. We employ the variational method with a large basis of interpolating operators enabling six energies in each irreducible representation of the lattice to be distinguished clearly. We compare our calculation with the low-lying experimental spectrum, with which we find reasonable agreement in the pattern of states. In addition, the need to include operators that couple to the expected multi-hadron states in the spectrum is clearly identified.« less

  10. Property:SurfaceManager | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    + COCONINO NF + AZA-009169 + COCONINO NF + AZA-009170 + COCONINO NF + AZA-009171 + FOREST SERVICE + AZA-009172 + FOREST SERVICE + AZA-009173 + FOREST SERVICE + AZA-009174 +...

  11. DOE/EIS-0203-SA-07 DOE/EA-1148-SA-01 DOE/EIS-0250F-S-1-SA-02

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ... at the West Valley Demonstration Project; SNF from fuel performance testing at Babcock and Wilcox Research Center; and special case SNF debris (Three-mile Island Unit 2)." ...

  12. EIS-0005-FS: Bonneville Power Administration Proposed FY 1979 Program, Facility Location on Supplement, Southwest Oregon Area Service, Buckley-Summer Lake 500 kV Line, Supplemental

    Office of Energy Efficiency and Renewable Energy (EERE)

    This Bonneville Power Administration document assesses the environmental impacts of constructing transmission facilities, which will coordinate with the Midpoint-Malin 500-kV line to be constructed by the Pacific Power and Light (PP&L) Company. The proposed action includes the construction of the 1.56-mile Buckley-Summer Lake 500-kV transmission line; the proposed Buckley Substation near Maupin, Oregon; and the proposed Summer Lake Substation near Silver Lake, Oregon.

  13. Report on Matters Identified at Strategic Petroleum Reserve During Audit of Statement of Financial Position, CR-FS-96-03

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    is an ASCII-formatted version of a printed document. The page numbers in this electronic version may not be in the same order as those in the printed document. The printed document may also contain charts and photographs which are not reproduced in this electronic version. If you require the printed version of this document, contact the Office of Inspector General (IG-1), Department of Energy, 1000 Independence Avenue, SW, Washington, DC, 20585, or call the Office of Inspector General Reports

  14. Pioglitazone inhibits angiotensin II-induced atrial fibroblasts proliferation via NF-?B/TGF-?1/TRIF/TRAF6 pathway

    SciTech Connect (OSTI)

    Chen, Xiao-qing; Liu, Xu; Wang, Quan-xing; Zhang, Ming-jian; Guo, Meng; Liu, Fang; Jiang, Wei-feng; Zhou, Li

    2015-01-01

    The exact mechanisms underlying inhibitory effects of pioglitazone (Pio) on Angiotensin II (AngII)-induced atrial fibrosis are complex and remain largely unknown. In the present study, we examined the effect of Pio on AngII-induced mice atrial fibrosis in vivo and atrial fibroblasts proliferation in vitro. In vivo study showed that AngII infusion induced atrial fibrosis and increased expressions of Toll/IL-1 receptor domain-containing adaptor inducing IFN-? (TRIF) and tumor necrosis factor receptor associated factor 6 (TRAF6) in mice models. However, those effects could be attenuated by Pio (P<0.01). As for in vitro experiment, Pio suppressed AngII-induced atrial fibroblasts proliferation via nuclear factor-?B/transforming growth factor-?1/TRIF/TRAF6 signaling pathway in primary cultured mice atrial fibroblasts (P<0.01). In conclusion, suppression of Pio on AngII-induced atrial fibrosis might be related to its inhibitory effects on above signaling pathway. - Highlights: Angiotensin II increased atrial fibrosis and related gene expressions in mice. Angiotensin II induced atrial fibroblasts proliferation by activating signaling pathway. Pioglitazone reversed both aforementioned changes.

  15. --No Title--

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Kayser (nu) Kayser (nu) Tribble (FS) Tribble (FS) Tribble (FS) TBA noon - 14:00 Jordan Lake lunch lunch lunch lunch Farewell lunch lunch 201 Chapman Hall 14:00 - 15:15 Open ...

  16. Lake Roosevelt Fisheries Evaluation Program : Limnological and Fisheries Monitoring Annual Report 1999.

    SciTech Connect (OSTI)

    McLellan, Holly; Lee, Chuck; Scofield, Ben; Pavlik, Deanne

    1999-08-01

    the recreational visits to the region. An increase in popularity has placed Lake Roosevelt fifth amongst the most visited State and Federal parks in Washington. Increased use of the reservoir prompted amplified efforts to enhance the Native American subsistence fishery and the resident sport fishery in 1984 with hatchery supplementation of rainbow trout (O. mykiss) and kokanee salmon (O. nerka). This was followed by the formation of the Spokane Tribal Lake Roosevelt Monitoring Project (LRMP) in 1988 and later by formation of the Lake Roosevelt Data Collection Project in 1991. The Lake Roosevelt Data Collection Project began in July 1991 as part of the BPA, Bureau of Reclamation, and U.S. Army Corps of Engineers System Operation Review process. This process sought to develop an operational scenario for the federal Columbia River hydropower system to maximize the in-reservoir fisheries with minimal impacts to all other stakeholders in the management of the Columbia River. The Lake Roosevelt Monitoring/Data Collection Program (LRMP) is the result of a merger between the Lake Roosevelt Monitoring Program (BPA No. 8806300) and the Lake Roosevelt Data Collection Project (BPA No. 9404300). These projects were merged in 1996 forming the Lake Roosevelt Monitoring Program (LRMP), which continues the work historically completed under the separate projects. The LRMP has two main goals. The first is to develop a biological model for Lake Roosevelt that will predict in-reservoir biological responses to a range of water management operational scenarios, and to develop fisheries and reservoir management strategies accordingly. The model will allow identification of lake operations that minimize impacts on lake biota while addressing the needs of other interests (e.g. flood control, hydropower generation, irrigation, and downstream resident and anadromous fisheries). Major components of the model will include: (1) quantification of entrainment and other impacts to phytoplankton

  17. mira_boot_camp_2015_harms_io.pptx

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    mira-fs0 14074.71 102400.00 none Performance Project mira-fs0 88247.11 102400.00 none StabilityHarness Project mira-fs0 1842.53 1842.53 none mira-fs1 : Current Project Quota...

  18. 1992 CBECS C & E

    U.S. Energy Information Administration (EIA) (indexed site)

    of District Heat by End Use, 1989 District Heat Consumption (trillion Btu) Space Water a Total Heating Heating Other RSE Building Row Characteristics Factor 1.0 NF NF NF RSE...

  19. 1992 CBECS C & E

    U.S. Energy Information Administration (EIA) (indexed site)

    0. Consumption of Fuel Oil by End Use, 1989 Fuel Oil Consumption (trillion Btu) Space Water a Total Heating Heating Other RSE Building Row Characteristics Factor 1.0 NF NF NF RSE...

  20. Report to Congress: Corridors and Rights-of-Way on Federal Lands...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Service (FS) of the U.S. Department of Agriculture and the Bureau of Land Management (BLM) of the U.S. Department of the Interior pursuant to Title V of FLPMA. The FS and the ...

  1. Department of Energy's Isotope Development and Production for...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Fiscal Year 2010 Balance Sheet Audit OAS-FS-13-11 February 2013 January 31, 2013 Mr. ... National Laboratory IG Report No. OAS-FS-13-11 CUSTOMER RESPONSE FORM The Office of ...

  2. Final Proposal Supporting Studies (ratecases/WP-02)

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    19, 2000 Rev. Req't Docu. - Volume 2 WP-02-FS-BPA-02B DOEBP-3284 618 May 19, 2000 RISK ANALYSIS STUDY WP-02-FS-BPA-03 DOEBP-3285 31 May 19, 2000 Risk Documentation...

  3. Consolidated Financial Statements | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    November 29, 2012 Audit Report: OAS-FS-13-06 Southwestern Federal Power System's Fiscal Year 2011 Financial Statement Audit November 28, 2012 Audit Report: OAS-FS-13-05 Department...

  4. Twofold Andreev reflections and coherent transport in ferromagnetic semiconductor/d-wave superconductor/ferromagnetic semiconductor double tunneling junctions

    SciTech Connect (OSTI)

    Tao, Y. C. E-mail: taoyongchun@njnu.edu.cn; Li, Z. P.; Ji, T. T.; Liu, S. Y.; Di, Y. S.

    2014-04-21

    Coherent transport in a ferromagnetic semiconductor (FS)/d-wave superconductor (SC)/FS structure with (110) interfaces is studied by extending Bogoliubov-de Gennes equation into eight components, in which the interband coupling of heavy and light hole bands in the FS, the strengths of potential scattering at the interfaces, and the mismatches in the effective mass and Fermi vector between the FS and SC are taken into account. Twofold Andreev reflections exist due to the existence of two bands in the FS, in which the incident hole and the two Andreev-reflected electrons, belonging to the different spin subbands, form twofold spin-singlet pairing states near the FS/SC interface. It is shown that due to the interplay of the SC with unconventional d-wave pairing symmetry and FS, the differential conductance and tunneling magnetoresistance exhibit an abundant dependence on not only the interband coupling in the FS but also the strengths of potential scattering at the interfaces. More importantly, the properties are found to be quite different from those in the FS/s-wave SC/FS structure with conventional pairing symmetry for the SC.

  5. Calendar Year 2013 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    3 Calendar Year 2013 December 20, 2013 Audit Report: OAS-FS-14-04 Federal Energy Regulatory Commission's Fiscal Year 2013 Financial Statement Audit December 12, 2013 Audit Report: OAS-FS-14-03 Department of Energy's Fiscal Year 2013 Consolidated Financial Statements December 11, 2013 Audit Report: OAS-FS-14-02 Department of Energy's Nuclear Waste Fund's Fiscal Year 2013 Financial Statement Audit December 6, 2013 Special Report: IG-0900 Department of Energy's July 2013 Cyber Security Breach

  6. CELLFS: TAKING THE "DMA" OUT OF CELL PROGRAMMING

    SciTech Connect (OSTI)

    IONKOV, LATCHESAR A.; MIRTCHOVSKI, ANDREY A.; NYRHINEN, AKI M.

    2007-01-09

    In this paper we present a new programming model for the Cell BE architecture of scalar multiprocessors. They call this programming model CellFS. CellFS aims at simplifying the task of managing I/O between the local store of the processing units and main memory. The CellFS support library provides the means for transferring data via simple file I/O operations between the PPU and the SPU.

  7. Consolidated Financial Statements | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Reports » Consolidated Financial Statements Consolidated Financial Statements October 31, 2016 Audit Report: OAI-FS-17-01 Management Letter on the Southwestern Federal Power System's Fiscal Year 2015 Financial Statement Audit August 29, 2016 Audit Report: OAI-FS-16-10 Southwestern Federal Power System's Fiscal Year 2015 Financial Statement Audit May 6, 2016 Audit Report: OAI-FS-16-09 Management Letter on the Western Federal Power System's Fiscal Year 2015 Financial Statement Audit April 21,

  8. CUFR Tree Carbon Calculator | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Desktop Application Website: www.fs.fed.usccrctopicsurban-forestsctcc Cost: Free Language: English References: CUFR Tree Carbon Calculator1 Overview "The CUFR Tree Carbon...

  9. Comments from

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Forest 3106 Pierce Parkway Suite D Springfield OR 97477 (541) 225-6348 khuddleston@fs.fed.us website: http:www.oregonfeb.usofebpagesofebsh aredneutrals.htm Workplace...

  10. Lighting in Commercial Buildings

    U.S. Energy Information Administration (EIA) (indexed site)

    (CEC), March 1990. Advanced Lighting Technologies Application Guidelines (ALTAG), Building and Appliance Efficiency Office. 3. Dubin, F.S., Mindell, H.L., and Bloome, S., 1976....

  11. Calendar Year 2015 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    2015 Audit Report OAS-FS-15-09 Audit of Costs Incurred Under the Department of Energy's International Nuclear Cooperation Program Interagency Agreements With the Department of...

  12. Management & Administration Reports | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    2015 Audit Report OAS-FS-15-09 Audit of Costs Incurred Under the Department of Energy's International Nuclear Cooperation Program Interagency Agreements With the Department of...

  13. Research Capabilities | ANSER Center | Argonne-Northwestern National...

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Wiederrecht, Wasielewski, and Chen) Ultrafast vibrational spectroscopy (IR transient absorption and fs-Raman) (PI: Wasielewski) Photo-modulated impedance (PI: Hupp) ...

  14. Energy use and domestic hot water consumption - Phase 1. Final...

    Office of Scientific and Technical Information (OSTI)

    The LMH approach and openquoteNationalclosequote guidelines were adopted for inclusion in the 1995 ASHRAE Handbook revision. less Authors: Goldner, F.S. 1 + Show Author ...

  15. Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Federal Energy Regulatory Commission's Fiscal Year 2013 Financial Statement Audit OAS-FS-14-01 ... Discussion and Analysis section be presented to supplement the financial statements. ...

  16. 107_4 Combined report on financial statements (unqualified opinion...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Commission's Fiscal Year 2009 Financial Statement Audit Report No.: OAS-FS-10-01 TO: ... The information in the Performance and Accounta for purposes of additional analysis ...

  17. Ultrafast Core-Hole Induced Dynamics in Water

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    isotope substitution experiments and molecular dynamics simulations, researchers from Sweden, Germany, and the U.S. have shown that the ultrafast (0- to 10-fs) dissociation...

  18. New developments in the area of topological insulators

    SciTech Connect (OSTI)

    Felser, Claudia; Yan, Binghai; Chadov, Stanislav; Kübler, Jürgen; Müchler, Lukas; Zhang, Shoucheng

    2015-12-31

    Topological insulators are a hot topic in condensed matter physics. A new topological insulator has been identified in cerium-filled skutterudite (FS) compounds.

  19. EIS-0285: Final Environmental Impact Statement, Volume 2 | Department...

    Energy.gov (indexed) [DOE]

    Certification Plan Appendix D - Sample Educational Information Appendix E - Clearance Criteria Appendix F - FS Mitigation Measures and Background Appendix G - BLM ...

  20. OHIO E.P.A.

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ... provide a framework for evaluating alternative technologies. ... employs a quadrant approach in which the Facility is ... intends to rely on modeling to satisfy any RifFS task, ...

  1. Remedial System Performance Improvement for the 200-ZP-1_PW-1...

    Office of Environmental Management (EM)

    ... continuing source when evaluating potential remedies is ... Modeling and Monitoring Results The FS may include consideration of several P&T approaches. For instance, one approach ...

  2. Uranium Enrichment Decontamination and Decommissioning Fund's...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Uranium Enrichment Decontamination and Decommissioning Fund's Fiscal Year 2008 and 2007 Financial Statement Audit, OAS-FS-10-05 Uranium Enrichment Decontamination and...

  3. WP-96/TR-96 & TC-96 Power and Transmission Rate Case (rates/ratecases...

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Of Decision (WP-96 ROD) Final Studies And Documentation (WP-96-FS) Loads and Resources Revenue Requirement Segmentation Marginal Cost Analysis Wholesale Power Rate Development...

  4. Felix Storch: Noncompliance Determination (2010-SCE-0111)

    Energy.gov [DOE]

    DOE issued a Notice of Noncompliance Determination to Felix Storch finding that basic model FS62, a compact upright freezer, does not comport with the energy conservation standards.

  5. AUDIT REPORT Department of Energy Nuclear Waste Fund's Fiscal...

    Office of Environmental Management (EM)

    Energy Nuclear Waste Fund's Fiscal Year 2015 Financial Statement Audit OAI-FS-16-03 ... Report on "Department of Energy Nuclear Waste Fund's Fiscal Year 2015 Financial ...

  6. Publications

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    ... implementation of a fs-resolved transmission electron microscope based on thermionic gun technology" in press at Chemical Physics D (2013) Mehraeen, S.; McKeown, J. T.; ...

  7. 100-D/H Remedial Investigation/ Feasibility Study /Proposed Plan

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Remedial Investigation/ Feasibility Study /Proposed Plan Nina Menard Washington State Department of Ecology 100-D/H RI/FS/PP * Received Draft RI/FS/PP on December 14, 2012 * Submitted comments to DOE on March 12, 2013 * DOE and Ecology are meeting to start the resolution process 100-D/H RI/FS/PP * Good points o Fairly well written o Results of borehole data didn't find any smoking guns. 100-D/H RI/FS/PP Issues o Selection of Contaminants Of Concern/Contaminants Of Potential Concern (COC/COPC) o

  8. USDA Forest Products Laboratory | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Forest Products Laboratory Jump to: navigation, search Name: USDA Forest Products Laboratory Place: Madison, WI Website: www.fpl.fs.fed.us References: USDA Forest Products...

  9. Neptunium Valence Chemistry in Anion Exchange Processing

    SciTech Connect (OSTI)

    KYSER, EDWARD

    2003-02-01

    The current anion resin in use in HB-Line Phase II, Reillex{trademark} HPQ, was tested in the laboratory under expected plant conditions for Np processing and was found to load between 50 and 70 g Np per liter of resin. Losses varied from 0.2 to 15 percent depending on a number of parameters. Hydrazine in the feed at 0.02 to 0.05 M appeared to keep the Np from oxidizing and increasing the losses within four to seven days after the FS addition. Losses of up to three percent were observed five days after FS addition when hydrazine was not used in the feed, compared with 0.3 percent when the feed was loaded immediately after FS addition. Based on these test results the following processing conditions are recommended: (1) Feed conditions: 8 M HNO{sub 3}, 0.02 M hydrazine, 0.05 M excess FS, less than 5 days storage of solution after FS addition. (2) Wash conditions: 100 liters of 8 M HNO{sub 3}, no FS, no hydrazine. (3) Elution conditions: 0.17 M HNO{sub 3}, 0.05 M hydrazine, no FS. (4) Precipitation feed conditions: 0.03 M excess ascorbic acid, no additional hydrazine, no FS, precipitation within three days.

  10. 2013 DOE Bioenergy Technologies Office (BETO) Project Peer Review

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ... Jim Perdue, USDA-FS, Southern Research Station Don Riemenschneider, USDA-FS, Northern ... A B C D E F G H I J NM6 Basal Area, sq. ft. Clone ID 0 0.04 0.08 0.12 0.16 1 2 3 4 5 6 7 8 ...

  11. Microsoft Word - DOE-ID-14-064 Illinois EC B3-6.doc

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    between available neutron-irradiated reference alloys (Grade 91, Grade 92 and NF709) and the ion irradiations on these materials, and (2) to use these correlations to...

  12. U.S. Plutonium "Pit" Production: Additional Facilities, Production

    National Nuclear Security Administration (NNSA)

    ... new facilities, subject to planned refurbishments, but without additional nuclear facilities such as the CMRR NF, could preserve and enhance pit production capability for ...

  13. NVN-074253 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1280 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

  14. NVN-074250 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1199 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

  15. NVN-077646 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Acres) Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 80 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

  16. NVN-079352 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Acres) Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1160 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

  17. NVN-074254 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2280 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

  18. NVN-079310 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 655 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

  19. NVN-079667 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1920 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

  20. NVN-079664 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1280 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

  1. NVN-079276 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 640 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

  2. NVN-079292 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1980.23 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

  3. UTU-085605 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Case Status Authorized Case Type GEOLSECOMPPOST2005 Total Acreage 2441.53 Bid PriceAcre Managing Field Office none provided Surface Manager FISHLAKE NF Lessee 1 ENEL...

  4. USFS Humboldt-Toiyabe National Forest | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    USFS Humboldt-Toiyabe National Forest Jump to: navigation, search Name: USFS Humboldt-Toiyabe National Forest Abbreviation: Humbolt-Toiyabe NF Address: 1200 Franklin Way Place:...

  5. Evolutionary analyses of non-family genes in plants

    SciTech Connect (OSTI)

    Ye, Chuyu; Li, Ting; Yin, Hengfu; Weston, David; Tuskan, Gerald A; Tschaplinski, Timothy J; Yang, Xiaohan

    2013-03-01

    There are a large number of non-family (NF) genes that do not cluster into families with three or more members per genome. While gene families have been extensively studied, a systematic analysis of NF genes has not been reported. We performed comparative studies on NF genes in 14 plant species. Based on the clustering of protein sequences, we identified ~94,000 NF genes across these species that were divided into five evolutionary groups: Viridiplantae-wide, angiosperm-specific, monocot-specific, dicot-specific, and those that were species-specific. Our analysis revealed that the NF genes resulted largely from less frequent gene duplications and/or a higher rate of gene loss after segmental duplication relative to genes in both low-copy-number families (LF; 3 10 copies per genome) and high-copy-number families (HF; >10 copies). Furthermore, we identified functions enriched in the NF gene set as compared with the HF genes. We found that NF genes were involved in essential biological processes shared by all plant lineages (e.g., photosynthesis and translation), as well as gene regulation and stress responses associated with phylogenetic diversification. In particular, our analysis of an Arabidopsis protein-protein interaction network revealed that hub proteins with the top 10% most connections were over-represented in the NF set relative to the HF set. This research highlights the roles that NF genes may play in evolutionary and functional genomics research.

  6. Evolutionary analyses of non-family genes in plants

    SciTech Connect (OSTI)

    Ye, Chuyu; Li, Ting; Yin, Hengfu; Weston, David; Tuskan, Gerald A; Tschaplinski, Timothy J; Yang, Xiaohan

    2013-01-01

    There are a large number of non-family (NF) genes that do not cluster into families with three or more members per genome. While gene families have been extensively studied, a systematic analysis of NF genes has not been reported. We performed comparative studies on NF genes in 14 plant species. Based on the clustering of protein sequences, we identified ~94 000 NF genes across these species that were divided into five evolutionary groups: Viridiplantae wide, angiosperm specific, monocot specific, dicot specific, and those that were species specific. Our analysis revealed that the NF genes resulted largely from less frequent gene duplications and/or a higher rate of gene loss after segmental duplication relative to genes in both lowcopy- number families (LF; 3 10 copies per genome) and high-copy-number families (HF; >10 copies). Furthermore, we identified functions enriched in the NF gene set as compared with the HF genes. We found that NF genes were involved in essential biological processes shared by all plant lineages (e.g. photosynthesis and translation), as well as gene regulation and stress responses associated with phylogenetic diversification. In particular, our analysis of an Arabidopsis protein protein interaction network revealed that hub proteins with the top 10% most connections were over-represented in the NF set relative to the HF set. This research highlights the roles that NF genes may play in evolutionary and functional genomics research.

  7. EIS-0350-S1: Mitigation Action Plan | Department of Energy

    Energy.gov (indexed) [DOE]

    Los Alamos, NM This Mitigation Action Plan (MAP) describes mitigation and monitoring commitments for constructing and operating the Modified CMRR-NF. The commitments made in this ...

  8. Carbon Free Developments | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Free Developments Jump to: navigation, search Name: Carbon Free Developments Place: United Kingdom Zip: W11 3NF Sector: Wind energy Product: UK-based onshore wind project...

  9. Tumor necrosis factor: specific binding and internalization in sensitive and resistant cells

    SciTech Connect (OSTI)

    Tsujimoto, M.; Yip, Y.K.; Vilcek, J.

    1985-11-01

    Highly purified, Escherichia coli-derived recombinant human tumor necrosis factor (TNF) was labeled with /sup 125/I and employed to determine receptor binding, internalization, and intracellular degradation in murine L929 cells (highly sensitive to the cytotoxic action of TNF) and in diploid human FS-4 cells (resistant to TNF cytotoxicity). /sup 125/I-labeled TNF bound specifically to high-affinity receptors on both L929 and FS-4 cells. Scatchard analysis of the binding data indicated the presence of 2200 binding sites per L929 cell and 7500 binding sites per FS-4 cell. The calculated dissociation constants are 6.1 x 10/sup -10/ M and 3.2 x 10/sup -10/ M for L929 and FS-4 cells, respectively. In both L929 and FS-4 cells, incubation at 37/sup 0/C resulted in a rapid internalization of the bulk of the cell-bound TNF, followed by the appearance of trichloroacetic acid-soluble /sup 125/I radioactivity in the tissue culture medium, due to degradation of TNF. Degradation but not cellular uptake of TNF was inhibited in the presence of chloroquine (an inhibitor of lysosomal proteases) in both L929 and FS-4 cells, suggesting that degradation occurs intracellularly, probably within lysosomes. These results show that resistance of FS-4 cells to TNF cytotoxicity is not due to a lack of receptors or their inability to internalize and degrade TNF.

  10. Slide 1

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    START of Process RI/FS Work Plan is finalized RI/FS Report is finalized Proposed Plan is issued for Public Comment ROD is issued Required Actions Required Notifications Publish a Notice of availability of Proposed Plan in a major local newspaper Publish a Notice of availability of ROD in a major local newspaper Optional activities for high-interest topics Solicit informal public input on the Work Plan Solicit informal public input on the RI/FS Solicit informal public input on the Proposed Plan

  11. Observing heme doming in myoglobin with femtosecond X-ray absorption spectroscopy

    DOE PAGES-Beta [OSTI]

    Levantino, M.; Lemke, H. T.; Schirò, G.; Glownia, M.; Cupane, A.; Cammarata, M.

    2015-07-01

    We report time-resolved X-ray absorption measurements after photolysis of carbonmonoxy myoglobin performed at the LCLS X-ray free electron laser with nearly 100 fs (FWHM) time resolution. Data at the Fe K-edge reveal that the photoinduced structural changes at the heme occur in two steps, with a faster (~70 fs) relaxation preceding a slower (~400 fs) one. We tentatively attribute the first relaxation to a structural rearrangement induced by photolysis involving essentially only the heme chromophore and the second relaxation to a residual Fe motion out of the heme plane that is coupled to the displacement of myoglobin F-helix.

  12. Microsoft PowerPoint - RCBRA Eco 10.12.11.pptx

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    RCBRA Ecological Risk Assessment Overview Hanford Advisory Board River and Plateau Committee October 2011 Purpose * River Corridor Baseline Risk Assessment - Ecological Risk f ( ) h b b d h Assessment Draft C (RCBRA-Eco) has been submitted to the Regulators * Information presented forms the basis for ecological risk in th Ri C id RI/FS d t the River Corridor RI/FS documents - The RCBRA-Eco is an evaluation across the River Corridor - The RI/FS documents use Operable Unit-specific information

  13. Observing heme doming in myoglobin with femtosecond X-ray absorption spectroscopya)

    DOE PAGES-Beta [OSTI]

    Levantino, M.; Lemke, H. T.; Schir, G.; Glownia, M.; Cupane, A.; Cammarata, M.

    2015-07-01

    We report time-resolved X-ray absorption measurements after photolysis of carbonmonoxy myoglobin performed at the LCLS X-ray free electron laser with nearly 100 fs (FWHM) time resolution. Data at the Fe K-edge reveal that the photoinduced structural changes at the heme occur in two steps, with a faster (~70 fs) relaxation preceding a slower (~400 fs) one. We tentatively attribute the first relaxation to a structural rearrangement induced by photolysis involving essentially only the heme chromophore and the second relaxation to a residual Fe motion out of the heme plane that is coupled to the displacement of myoglobin F-helix.

  14. Generation of Femtosecond Electron And Photon Pulses

    SciTech Connect (OSTI)

    Thongbai, C.; Jinamoon, V.; Kangrang, M.; Kusoljariyakul, K.; Rimjaem, S.; Saisut, J.; Vilaithong, T.; Rhodes, M.W.; Wichaisirimongkol, P.; Wiedemann, H.; /SLAC

    2006-03-17

    Femtosecond (fs) electron and photon pulses become a tool of increasing importance to study dynamics in ultrafast processes. Such short electron pulses can be generated from a system consisting of a thermionic-cathode RF-gun and a magnetic bunch compressor. The fs electron pulses can be used directly or used as a source to produce equally short electromagnetic radiation pulses via certain kind of radiation production processes. At the Fast Neutron Research Facility (FNRF), Thailand, we are especially interested in production of radiation in Farinfrared and X-ray regime. In the far-infrared wavelengths, the radiation emitted from fs electron pulses is emitted coherently resulting high intensity radiation. In the X-ray regime, development of fs X-ray sources is crucial for application in ultrafast sciene.

  15. Daniel Udwary NERSC Data Science Engagement Group"

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Feb 8 Mendel+ Legacy Computes Feb 22? Mendel Outage @CRT @OSF Filesystems Scheduler Down6me for power work and networking maintenance ? SeqFS Key Differences Between CoriEdison ...

  16. Slide 1

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    ...FS) Draft A reports and Proposed Plans to EPA and Ecology * Tri-Party Agreement (TPA) ... - Draft A RIFS Work Plan transmitted to EPA on 122711 - EPA's comments received on 5...

  17. Dissecting X-Ray Raman Resonances Using Four-Wave Mixing (Conference...

    Office of Scientific and Technical Information (OSTI)

    where it is possible to eliminate stimulated emission and excited-state absorption by taking the waiting time to be longer the lifetime of the core hole ( 7:1 fs for nitrogen). ...

  18. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    ... emission and excited-state absorption by taking the waiting time to be longer the lifetime of the core hole ( 7:1 fs formore nitrogen). less January 2013 , EDP Sciences

  19. Momentum-space electronic structures and charge orders of the high-temperature superconductors Ca2-xNaxCuO₂Cl₂ and Bi₂Sr₂CaCu₂O8+δ

    DOE PAGES-Beta [OSTI]

    Meng, Jian-Qiao; Brunner, M.; Kim, K.-H.; Lee, H.-G.; Lee, S.-I.; Wen, J. S.; Xu, Z. J.; Gu, G. D.; Gweon, G.-H.

    2011-08-24

    We study the electronic structure of Ca2-xNaxCuO₂Cl₂ and Bi₂Sr₂CaCu₂O8+δ samples in a wide range of doping, using angle-resolved photoemission spectroscopy, with emphasis on the Fermi surface (FS) in the near antinodal region. The “nesting wave vector,” i.e., the wave vector that connects two nearly flat pieces of the FS in the antinodal region, reveals a universal monotonic decrease in magnitude as a function of doping. Comparing our results to the charge order recently observed by scanning tunneling spectroscopy (STS), we conclude that the FS nesting and the charge order pattern seen in STS do not have a direct relationship. Therefore,more » the charge order likely arises due to strong-correlation physics rather than FS nesting physics« less

  20. Microsoft Word - Transmittal Memo - FY 2007 Isotopes Final Report...

    Energy.gov (indexed) [DOE]

    OAS-FS-11-06 TO: Director, Office of Science Director, Facilities and Project Management Division, Office of Nuclear Physics The attached report presents the results of the ...

  1. Geothermal/Leasing | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Office NVN-085710 Oski Energy LLC BLM BLM Carson City District Office NVN-085711 Oski Energy LLC BLM BLM Carson City District Office USDA-FS-EA-NV-030-06-025 2007 EA Vulcan...

  2. Using Light to Control How X Rays Interact with Matter

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    ... (70-300 fs) are focused to attain the required intensity (1013 Wcm2). ... Publication about this research: T.E. Glover, M.P. Hertlein, S.H. Southworth, T.K. Allison, J. van ...

  3. Nanophotonics Capabilities | Argonne National Laboratory

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Nanophotonics Capabilities Transient absorption spectroscopy Laser excitation: 250-1200 nm Probe wavelength range: 300-1450 nm Delay times <100 fs-0.1 ms Time-resolved emission...

  4. Observed Aerosol Radiative Forcings: Comparison for Natural...

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    ... A method has been developed to standardize F(s) at all locations for a "reference day," which is defined here as an equinox day at the equator over an ocean surface. The current ...

  5. Final Supplemental Environmental Impact Statement for a Geologic...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Nuclear Fuel and High-Level Radioactive Waste at Yucca Mountain, Nye County, Nevada - Nevada Rail Transportation Corridor DOEEIS-0250F-S2 and Final En Final Supplemental ...

  6. AFM report to Coastline Optic

    SciTech Connect (OSTI)

    Brejnholt, Nicolai F.

    2015-06-26

    This report briefly outlines results from AFM on Coastline plano-plano fused silica substrate serial number 1.0-FS-PL-3356 to establish if high spatial frequency roughness meets requirements.

  7. Resonant Soft X-Ray Scattering of Tri-Block Copolymers

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    enormous parameter space for the creation of new morphologies. Illustration from F.S. Bates and G.H. Fredrickson, "Block copolymers-designer soft materials," Physics Today 52, 32...

  8. Femtosecond NEXAFS of Photoinduced Insulator-Metal Transition...

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    ... Both processes occur on the 100-fs time scale. Left: Atomic rearrangements in the ... To date, the lack of femtosecond x-ray sources that are tunable over a broad spectral ...

  9. Calendar Year 1999 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    May 25, 1999 Audit Report: ER-FS-99-01 Results of Audit Procedures Performed at Chicago Operations Office During the Audit of the Department's Consolidated Fiscal Year 1998...

  10. U.S. Department of Energy Office of Inspector General

    Energy.gov (indexed) [DOE]

    Nuclear Waste Fund's Fiscal Year 2013 Financial Statement Audit OAS-FS-14-02 December 2013 ... Audit Report on "Department of Energy's Nuclear Waste Fund's Fiscal Year 2013 Financial ...

  11. LA-UR-12-23586 Team Members: Matthew Broomfield (New Mexico Tech...

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    * Can be used over Infiniband or Ethernet * Can be tuned for speed andor resilience * Flexible administration Why Use GlusterFS? LA-UR-12-23586 l Enterprise...

  12. Consolidated Financial Statements | Department of Energy

    Energy.gov (indexed) [DOE]

    Technology Management Letter on the Audit of the Department of Energy's Consolidated Balance Sheet for Fiscal Year 2008 November 13, 2008 Audit Report: OAS-FS-09-02 Federal...

  13. Nandan Project Development Company | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Development Company is a SPV set up between Nandan Biomatrix and IL&FS to build a bio investment eco industrial zone (BIEZ) in India. References: Nandan Project Development...

  14. NREL Works to Increase Electric Vehicle Efficiency Through Enhanced...

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    FS-6A42-62241 * June 2014 NREL prints on paper that contains recycled content. NREL Works to Increase Electric Vehicle Efficiency Through Enhanced Thermal Management Researchers at ...

  15. 2010nuclearfuture_memo.pdf | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    nuclearfuture_memo.pdf 2010nuclearfuture_memo.pdf (9.14 KB) More Documents & Publications Microsoft Word - BRC Charter Secretarial Determination of the Adequacy of the Nuclear Waste Fund Fee Audit Report: OAS-FS-12-03

  16. Direct writing of continuous and discontinuous sub-wavelength periodic surface structures on single-crystalline silicon using femtosecond laser

    SciTech Connect (OSTI)

    Kuladeep, Rajamudili; Sahoo, Chakradhar; Narayana Rao, Desai E-mail: dnr-laserlab@yahoo.com

    2014-06-02

    Laser-induced ripples or uniform arrays of continuous near sub-wavelength or discontinuous deep sub-wavelength structures are formed on single-crystalline silicon (Si) by femtosecond (fs) laser direct writing technique. Laser irradiation was performed on Si wafers at normal incidence in air and by immersing them in dimethyl sulfoxide using linearly polarized Ti:sapphire fs laser pulses of ∼110 fs pulse duration and ∼800 nm wavelength. Morphology studies of laser written surfaces reveal that sub-wavelength features are oriented perpendicular to laser polarization, while their morphology and spatial periodicity depend on the surrounding dielectric medium. The formation mechanism of the sub-wavelength features is explained by interference of incident laser with surface plasmon polaritons. This work proves the feasibility of fs laser direct writing technique for the fabrication of sub-wavelength features, which could help in fabrication of advanced electro-optic devices.

  17. The TriBeam system: Femtosecond laser ablation in situ SEM

    SciTech Connect (OSTI)

    Echlin, McLean P.; Straw, Marcus; Randolph, Steven; Filevich, Jorge; Pollock, Tresa M.

    2015-02-15

    Femtosecond laser ablation offers the unique ability to remove material at rates that are orders of magnitude faster than existing ion beam technologies with little or no associated damage. By combining ultrafast lasers with state-of-the-art electron microscopy equipment, we have developed a TriBeam system capable of targeted, in-situ tomography providing chemical, structural, and topographical information in three dimensions of near mm{sup 3} sized volumes. The origins, development, physics, current uses, and future potential for the TriBeam system are described in this tutorial review. - Graphical abstract: Display Omitted - Highlights: • An emerging tool, the TriBeam, for in situ femtosecond (fs) laser ablation is presented. • Fs laser ablation aided tomography at the mm{sup 3}-scale is demonstrated. • Fs laser induced deposition of Pt is demonstrated at sub-diffraction limit resolution. • Fs laser surface structuring is reviewed as well as micromachining applications.

  18. Femtosecond Time-Delay X-ray Holography

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    optics to the X-ray regime, such as holography, interferometry, and laser-based imaging. ... Those experiments showed that no damage occurred during the 30 fs duration pulse. However, ...

  19. Breakthrough in femtosecond X-ray protein nanocrystallography

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    ... a crucial role in the measurements. The duration of the laser pulse is 10 fs (10-14 sec). ... will allow in the future further reducing damage of the crystals and performing ...

  20. crd title p1.ai | Department of Energy

    Energy Savers

    for the Disposal of Spent Nuclear Fuel and High-Level Radioactive Waste at Yucca Mountain, Nye County, Nevada - Nevada Rail Transportation Corridor DOEEIS-0250F-S2 and ...

  1. USFS | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Name: United States Forest Service Abbreviation: USFS Address: 1400 Independence Ave., SW Place: Washington, D.C. Zip: 20250-1111 Year Founded: 1905 Website: www.fs.fed.us...

  2. Microwave guiding in air along single femtosecond laser filament

    SciTech Connect (OSTI)

    Ren Yu; Alshershby, Mostafa; Qin Jiang; Hao Zuoqiang; Lin Jingquan

    2013-03-07

    Microwave guiding along single plasma filament generated through the propagation of femtosecond (fs) laser pulses in air has been demonstrated over a distance of about 6.5 cm, corresponding to a microwave signal intensity enhancement of more than 3-fold over free space propagation. The current propagation distance along the fs laser filament is in agreement with the calculations and limited by the relatively high resistance of the single plasma filament. Using a single fs laser filament to channel microwave radiation considerably alleviate requirements to the power of fs laser pulses compared to the case of the circular filaments waveguide. In addition, it can be used as a simple and non-intrusive method to obtain the basic parameters of laser-generated plasma filament.

  3. Department of Energy's Nuclear Waste Fund's Fiscal Year 2012...

    Office of Environmental Management (EM)

    Nuclear Waste Fund's Fiscal Year 2012 Financial Statements OAS-FS-13-05 November 2012 U.S. ... Report on "Department of Energy's Nuclear Waste Fund's Fiscal Year 2012 Financial ...

  4. Department of Energy's Nuclear Waste Fund's Fiscal Year 2014...

    Office of Environmental Management (EM)

    Nuclear Waste Fund's Fiscal Year 2014 Financial Statement Audit OAS-FS-15-03 November 2014 ... Report on "Department of Energy's Nuclear Waste Fund's Fiscal Year 2014 Financial ...

  5. Momentum-space electronic structures and charge orders of the high-temperature superconductors Ca2-xNaxCuO₂Cl₂ and Bi₂Sr₂CaCu₂O8+δ

    DOE PAGES-Beta [OSTI]

    Meng, Jian-Qiao; Brunner, M.; Kim, K.-H.; Lee, H.-G.; Lee, S.-I.; Wen, J. S.; Xu, Z. J.; Gu, G. D.; Gweon, G.-H.

    2011-08-24

    We study the electronic structure of Ca2-xNaxCuO₂Cl₂ and Bi₂Sr₂CaCu₂O8+δ samples in a wide range of doping, using angle-resolved photoemission spectroscopy, with emphasis on the Fermi surface (FS) in the near antinodal region. The “nesting wave vector,” i.e., the wave vector that connects two nearly flat pieces of the FS in the antinodal region, reveals a universal monotonic decrease in magnitude as a function of doping. Comparing our results to the charge order recently observed by scanning tunneling spectroscopy (STS), we conclude that the FS nesting and the charge order pattern seen in STS do not have a direct relationship. Therefore,more »the charge order likely arises due to strong-correlation physics rather than FS nesting physics« less

  6. Conceptual Thermal Treatment Technologies Feasibility Study

    SciTech Connect (OSTI)

    Suer, A.

    1996-02-28

    This report presents a conceptual Thermal Treatment Technologies Feasibility Study (FS) for the Savannah River Site (SRS) focusing exclusively on thermal treatment technologies for contaminated soil, sediment, or sludge remediation projects.

  7. An ABCA1 truncation shows no dominant negative effect in a familial hypoalphalipoproteinemia pedigree with three ABCA1 mutations

    SciTech Connect (OSTI)

    Sorrenson, Brie; Suetani, Rachel J.; Bickley, Vivienne M.; George, Peter M.; Williams, Michael J.A.; Scott, Russell S.; McCormick, Sally P.A.

    2011-06-10

    Highlights: {yields} Characterisation of an ABCA1 truncation mutant, C978fsX988, in a pedigree with three ABCA1 mutations. {yields} Functional analysis of C978fsX988 in patient fibroblasts and HEK 293 cells shows no cholesterol efflux function. {yields} Allele-specific quantification shows C978fsX988 not expressed at mRNA level in fibroblasts. {yields} Unlike other ABCA1 truncations, C978fsX988 mutant shows no dominant negative effect at mRNA or protein level. -- Abstract: The ATP binding cassette transporter (ABCA1) A1 is a key determinant of circulating high density lipoprotein cholesterol (HDL-C) levels. Mutations in ABCA1 are a major genetic contributor to low HDL-C levels within the general population. Following the finding of three different ABCA1 mutations, p.C978fsX988, p.T1512M and p.N1800H in a subject with hypoalphalipoproteinemia, we aimed to establish whether the p.C978fsX988 truncation exerted a dominant negative effect on the full-length ABCA1 alleles within family members as has been reported for other ABCA1 truncations. Characterisation of the p.C978fsX988 mutant in transfected HEK 293 cells showed it to be expressed as a GFP fusion protein but lacking in cholesterol efflux function. This was in keeping with results from cholesterol efflux assays in the fibroblasts of p.C978fsX988 carriers which also showed impaired efflux. Allele- specific quantification of p.C978fsX988 mRNA and analysis of ABCA1 protein levels in the fibroblasts of p.C978fsX988 heterozygotes showed negligible levels of mRNA and protein expression. There was no evidence of a dominant negative effect on wildtype or p.N1800H protein levels. We conclude that in the case of the p.C978fsX988 truncated mutant a lack of expression precludes it from having a dominant negative effect.

  8. Hanford Site Cleanup Completion Framework - Hanford Site

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Documents Hanford Site Cleanup Completion Framework Documents Documents Hanford Site Cleanup Completion Framework Tri-Party Agreement Freedom of Information and Privacy Act Hanford Site Budget Hanford Site Safety Standards DOE - ORP Contracts/Procurements DOE - RL Contracts/Procurements Integrated Waste Feed Delivery Plan Single-Shell Tank Evaluations Deep Vadose Zone 100-F RI/FS 100-D/H Operable Units RI/FS Sitewide Probabilistic Seismic Hazard Analysis Environmental Hanford Site Cleanup

  9. Hanford Site Safety Standards - Hanford Site

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Hanford Site Safety Standards Documents Documents Hanford Site Cleanup Completion Framework Tri-Party Agreement Freedom of Information and Privacy Act Hanford Site Budget Hanford Site Safety Standards Hanford Hoisting and Rigging Manual DOE - ORP Contracts/Procurements DOE - RL Contracts/Procurements Integrated Waste Feed Delivery Plan Single-Shell Tank Evaluations Deep Vadose Zone 100-F RI/FS 100-D/H Operable Units RI/FS Sitewide Probabilistic Seismic Hazard Analysis Environmental Hanford Site

  10. Hanford Sitewide Probabilistic Seismic Hazard Analysis - Hanford Site

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Sitewide Probabilistic Seismic Hazard Analysis Documents Documents Hanford Site Cleanup Completion Framework Tri-Party Agreement Freedom of Information and Privacy Act Hanford Site Budget Hanford Site Safety Standards DOE - ORP Contracts/Procurements DOE - RL Contracts/Procurements Integrated Waste Feed Delivery Plan Single-Shell Tank Evaluations Deep Vadose Zone 100-F RI/FS 100-D/H Operable Units RI/FS Sitewide Probabilistic Seismic Hazard Analysis Environmental Hanford Sitewide Probabilistic

  11. Integrated Waste Feed Delivery Plan - Hanford Site

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Documents Integrated Waste Feed Delivery Plan Documents Documents Hanford Site Cleanup Completion Framework Tri-Party Agreement Freedom of Information and Privacy Act Hanford Site Budget Hanford Site Safety Standards DOE - ORP Contracts/Procurements DOE - RL Contracts/Procurements Integrated Waste Feed Delivery Plan Single-Shell Tank Evaluations Deep Vadose Zone 100-F RI/FS 100-D/H Operable Units RI/FS Sitewide Probabilistic Seismic Hazard Analysis Environmental Email Email Page | Print Print

  12. Single-Shell Tank Evaluations - Hanford Site

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Single-Shell Tank Evaluations Documents Documents Hanford Site Cleanup Completion Framework Tri-Party Agreement Freedom of Information and Privacy Act Hanford Site Budget Hanford Site Safety Standards DOE - ORP Contracts/Procurements DOE - RL Contracts/Procurements Integrated Waste Feed Delivery Plan Single-Shell Tank Evaluations Deep Vadose Zone 100-F RI/FS 100-D/H Operable Units RI/FS Sitewide Probabilistic Seismic Hazard Analysis Environmental Email Email Page | Print Print Page | Text

  13. Semiannual Report to Congress: October 1, 1995 - March 31, 1996 |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy 5 - March 31, 1996 Semiannual Report to Congress: October 1, 1995 - March 31, 1996 April 31, 1996 1996 Inspector General Semiannual Report to Congress DOE Semiannual Report ending March 31, 1996 Semiannual Report to Congress: October 1, 1995 - March 31, 1996 (260.55 KB) More Documents & Publications Semiannual Report to Congress: April 1, 1996 - September 30, 1996 Audit Report: WR-FS-96-01 Audit Report: IG-FS-96-01

  14. Soliton delivery of few-cycle optical gigawatt pulses in Kagome-lattice hollow-core photonic crystal fibers

    SciTech Connect (OSTI)

    Im, Song-Jin; Husakou, Anton; Herrmann, Joachim

    2010-08-15

    We study the delivery of few-cycle soliton-like pulses at 800 nm with gigawatt power or microjoule energy through a hollow-core kagome-lattice photonic crystal fiber over 1 m with preserved temporal and spectral shape. We show that with optimized pressure of the argon filling, 5 fs input pulses are compressed up to 2.5 fs after 20 cm and restore their shape after 1 m propagation.

  15. Microsoft PowerPoint - Top 3 Issues_1 Accomplishment_1 Activity_Presentation 052311.ppt [Compatibility Mode]

    Office of Environmental Management (EM)

    Chairs Meeting June 15-16, 2011 ◊ North Las Vegas, Nevada Hanford Solid Waste Burial Grounds 450,000 cubic meters radioactive solid waste in unlined trenches Draft Tank Closure & Waste Management Environmental Impact Statement identified unacceptable impacts to groundwater DOE preparing 200-SWBG RCRA Facility Investigation/ Corrective Measures Study and Remedial Investigation/ Feasibility Study (RI/FS) Work Plan that will Study and Remedial Investigation/ Feasibility Study (RI/FS) Work

  16. NEPA - Categorical Exclusions - Hanford Site

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Documents Environmental NEPA - Categorical Exclusions Documents Documents Hanford Site Cleanup Completion Framework Tri-Party Agreement Freedom of Information and Privacy Act Hanford Site Budget Hanford Site Safety Standards DOE - ORP Contracts/Procurements DOE - RL Contracts/Procurements Integrated Waste Feed Delivery Plan Single-Shell Tank Evaluations Deep Vadose Zone 100-F RI/FS 100-D/H Operable Units RI/FS Sitewide Probabilistic Seismic Hazard Analysis Environmental CERCLA Five-Year Review

  17. NEPA - Environmental Assessments - Hanford Site

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Assessments Documents Documents Hanford Site Cleanup Completion Framework Tri-Party Agreement Freedom of Information and Privacy Act Hanford Site Budget Hanford Site Safety Standards DOE - ORP Contracts/Procurements DOE - RL Contracts/Procurements Integrated Waste Feed Delivery Plan Single-Shell Tank Evaluations Deep Vadose Zone 100-F RI/FS 100-D/H Operable Units RI/FS Sitewide Probabilistic Seismic Hazard Analysis Environmental CERCLA Five-Year Review NEPA - Categorical Exclusions NEPA -

  18. NEPA - Environmental Impact Statements - Hanford Site

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Statements Documents Documents Hanford Site Cleanup Completion Framework Tri-Party Agreement Freedom of Information and Privacy Act Hanford Site Budget Hanford Site Safety Standards DOE - ORP Contracts/Procurements DOE - RL Contracts/Procurements Integrated Waste Feed Delivery Plan Single-Shell Tank Evaluations Deep Vadose Zone 100-F RI/FS 100-D/H Operable Units RI/FS Sitewide Probabilistic Seismic Hazard Analysis Environmental CERCLA Five-Year Review NEPA - Categorical Exclusions NEPA -

  19. CERCLA Five-Year Review - Hanford Site

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Documents Environmental CERCLA Five-Year Review Documents Documents Hanford Site Cleanup Completion Framework Tri-Party Agreement Freedom of Information and Privacy Act Hanford Site Budget Hanford Site Safety Standards DOE - ORP Contracts/Procurements DOE - RL Contracts/Procurements Integrated Waste Feed Delivery Plan Single-Shell Tank Evaluations Deep Vadose Zone 100-F RI/FS 100-D/H Operable Units RI/FS Sitewide Probabilistic Seismic Hazard Analysis Environmental CERCLA Five-Year Review Third

  20. Deep Vadose Zone - Hanford Site

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Documents Deep Vadose Zone Documents Documents Hanford Site Cleanup Completion Framework Tri-Party Agreement Freedom of Information and Privacy Act Hanford Site Budget Hanford Site Safety Standards DOE - ORP Contracts/Procurements DOE - RL Contracts/Procurements Integrated Waste Feed Delivery Plan Single-Shell Tank Evaluations Deep Vadose Zone 100-F RI/FS 100-D/H Operable Units RI/FS Sitewide Probabilistic Seismic Hazard Analysis Environmental Email Email Page | Print Print Page | Text Increase

  1. Documents - Hanford Site

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Documents Documents Documents Documents Hanford Site Cleanup Completion Framework Tri-Party Agreement Freedom of Information and Privacy Act Hanford Site Budget Hanford Site Safety Standards DOE - ORP Contracts/Procurements DOE - RL Contracts/Procurements Integrated Waste Feed Delivery Plan Single-Shell Tank Evaluations Deep Vadose Zone 100-F RI/FS 100-D/H Operable Units RI/FS Sitewide Probabilistic Seismic Hazard Analysis Environmental Documents Email Email Page | Print Print Page | Text

  2. Documents - Hanford Site

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Documents Documents Documents Hanford Site Cleanup Completion Framework Tri-Party Agreement Freedom of Information and Privacy Act Hanford Site Budget Hanford Site Safety Standards DOE - ORP Contracts/Procurements DOE - RL Contracts/Procurements Integrated Waste Feed Delivery Plan Single-Shell Tank Evaluations Deep Vadose Zone 100-F RI/FS 100-D/H Operable Units RI/FS Sitewide Probabilistic Seismic Hazard Analysis Environmental Documents Email Email Page | Print Print Page | Text Increase Font

  3. Central Plateau Inner Area Cleanup Principles

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Inner Area Cleanup Principles * Cleanup Principles are the initial conditions and approaches to developing cleanup decisions in the Inner Area * These Principles will guide the development of the Remedial Investigations and Feasibility Studies (RI/FS) * These Principles will help DOE produce RI/FS documents to better meet regulator expectations * Formal agreement on cleanup, as influenced by these Principles, does not happen until the Record of Decision What are Cleanup Principles? 2 * The Inner

  4. Influence of the Torsion Angle in 3,3'-Dimethyl-2,2'-bipyridine on the Intermediate Valence of Yb in (C5Me5)2 Yb(3,3'-Me2-bipy)

    SciTech Connect (OSTI)

    Nocton, Grégory; Booth, Corwin H.; Maron, Laurent; Andersen, Richard A.

    2014-06-26

    The synthesis and X-ray crystal structures of Cp-2*Yb(3,3'-Me(2)bipy) and [Cp-2 Yb(3,3'-Me(2)bipy)][Cp-2 YbCl1.6I0.4]center dot CH2Cl2 are described. In both complexes, the NCCN torsion angles are approximately 40 degrees. The temperature-independent value of n(f) of 0.17 shows that the valence of ytterbium in the neutral adduct is multiconfigurational, in reasonable agreement with a CASSCF calculation that yields a n(f) value of 0.27; that is, the two configurations in the wave function are f(13)(pi(1))(1) and f(14)(pi(1))(0) in a ratio of 0.27:0.73, respectively, and the open-shell singlet lies 0.28 eV below the triplet state (n(f) accounts for f-hole occupancy; that is, n(f) = 1 when the configuration is f(13) and n(f) = 0 when the configuration is f(14)). A correlation is outlined between the value of nf and the individual ytterbocene and bipyridine fragments such that, as the reduction potentials of the ytterbocene cation and the free x,x'-R-2-bipy ligands approach each other, the value of nf and therefore the f(13):f(14) ratio reaches a maximum; conversely, the ratio is minimized as the disparity increases.

  5. Ullrich-Turner syndrome and neurofibromatosis-1

    SciTech Connect (OSTI)

    Schorry, E.K.; Lovell, A.M.; Saal, H.M.; Milatovich, A.

    1996-12-30

    There is a well-known association between neurofibromatosis-1 (NF1) and Noonan syndrome-like manifestations, including short stature, short broad neck, and hypertelorism. These anomalies are thought to be due to variable expression of the NF1 gene. We report on two girls with NF1 who were found to have the Ullrich-Turner syndrome. Case 1, a 12-year-old white girl, was followed in a Neurofibromatosis Clinic because of multiple cafe-au-lait spots and a family history of NF1 in her mother and sister. On examination, she had short stature, hypertelorism, and short neck with low posterior hairline. Karyotype was 86% 46,XY/14% 45,X. Case 2, the first child of a woman with NF1, presented at birth with lymphedema of hands and feet and a short broad neck. Karyotype was 45,X. At age 23 months she was short, had epicanthic folds, hypertelorism, narrow palate, right simian crease, 19 cafe-au-lait spots, and axillary freckling. We conclude that chromosome studies should be performed in girls with NF1 who have short stature and Noonan- or Ullrich-Turner-like findings. Dilemmas raised by the dual diagnoses of NF1 and Ullrich-Turner syndrome include potential risks of growth hormone therapy and estrogen replacement therapy. 14 refs., 2 figs.

  6. miR-15a/16 Enhances Radiation Sensitivity of Non-Small Cell Lung Cancer

    Office of Scientific and Technical Information (OSTI)

    Cells by Targeting the TLR1/NF-κB Signaling Pathway (Journal Article) | SciTech Connect miR-15a/16 Enhances Radiation Sensitivity of Non-Small Cell Lung Cancer Cells by Targeting the TLR1/NF-κB Signaling Pathway Citation Details In-Document Search Title: miR-15a/16 Enhances Radiation Sensitivity of Non-Small Cell Lung Cancer Cells by Targeting the TLR1/NF-κB Signaling Pathway Purpose: Many miRNAs have been identified as essential issues and core determining factors in tumor radiation.

  7. Fast Spectrum Molten Salt Reactor Options

    SciTech Connect (OSTI)

    Gehin, Jess C; Holcomb, David Eugene; Flanagan, George F; Patton, Bruce W; Howard, Rob L; Harrison, Thomas J

    2011-07-01

    During 2010, fast-spectrum molten-salt reactors (FS-MSRs) were selected as a transformational reactor concept for light-water reactor (LWR)-derived heavy actinide disposition by the Department of Energy-Nuclear Energy Advanced Reactor Concepts (ARC) program and were the subject of a preliminary scoping investigation. Much of the reactor description information presented in this report derives from the preliminary studies performed for the ARC project. This report, however, has a somewhat broader scope-providing a conceptual overview of the characteristics and design options for FS-MSRs. It does not present in-depth evaluation of any FS-MSR particular characteristic, but instead provides an overview of all of the major reactor system technologies and characteristics, including the technology developments since the end of major molten salt reactor (MSR) development efforts in the 1970s. This report first presents a historical overview of the FS-MSR technology and describes the innovative characteristics of an FS-MSR. Next, it provides an overview of possible reactor configurations. The following design features/options and performance considerations are described including: (1) reactor salt options-both chloride and fluoride salts; (2) the impact of changing the carrier salt and actinide concentration on conversion ratio; (3) the conversion ratio; (4) an overview of the fuel salt chemical processing; (5) potential power cycles and hydrogen production options; and (6) overview of the performance characteristics of FS-MSRs, including general comparative metrics with LWRs. The conceptual-level evaluation includes resource sustainability, proliferation resistance, economics, and safety. The report concludes with a description of the work necessary to begin more detailed evaluation of FS-MSRs as a realistic reactor and fuel cycle option.

  8. Systems and methods for treating material

    DOE Patents [OSTI]

    Scheele, Randall D; McNamara, Bruce K

    2014-10-21

    Systems for treating material are provided that can include a vessel defining a volume, at least one conduit coupled to the vessel and in fluid communication with the vessel, material within the vessel, and NF.sub.3 material within the conduit. Methods for fluorinating material are provided that can include exposing the material to NF.sub.3 to fluorinate at least a portion of the material. Methods for separating components of material are also provided that can include exposing the material to NF.sub.3 to at least partially fluorinate a portion of the material, and separating at least one fluorinated component of the fluorinated portion from the material. The materials exposed to the NF.sub.3 material can include but are not limited to one or more of U, Ru, Rh, Mo, Tc, Np, Pu, Sb, Ag, Am, Sn, Zr, Cs, Th, and/or Rb.

  9. Bioremediation of contaminated groundwater

    DOE Patents [OSTI]

    Hazen, T.C.; Fliermans, C.B.

    1994-01-01

    Disclosed is an apparatus and method for in situ remediation of contaminated subsurface soil or groundwater contaminated by chlorinated hydrocarbons. A nutrient fluid (NF) is selected to simulated the growth and reproduction of indigenous subsurface microorganisms capable of degrading the contaminants; an oxygenated fluid (OF) is selected to create an aerobic environment with anaerobic pockets. NF is injected periodically while OF is injected continuously and both are extracted so that both are drawn across the plume. NF stimulates microbial colony growth; withholding it periodically forces the larger, healthy colony of microbes to degrade the contaminants. Treatment is continued until the subsurface concentration of contaminants is acceptable. NF can be methane and OF be air, for stimulating production of methanotrophs to break down chlorohydrocarbons, especially TCE and tetrachloroethylene.

  10. Worksheet

    U.S. Energy Information Administration (EIA) (indexed site)

    554,"Ames City of",6,2,"MidAmerican Energy Co.","NF",52,0,0,3171,3171 554,"Ames City ... 590,"Anaheim City of",6,3,"B P energy",,660,,,49925,49925 590,"Anaheim City ...

  11. AZA-009169 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    (40 Acres) Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 2560 Bid PriceAcre Managing Field Office none provided Surface Manager COCONINO NF Lessee 1 HUNT W H...

  12. AZA-009170 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    (40 Acres) Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 1920 Bid PriceAcre Managing Field Office none provided Surface Manager COCONINO NF Lessee 1 HUNT W H...

  13. NVN-077739 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Lot Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1271.82 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 PATUA...

  14. AZA-009168 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    (40 Acres) Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 2005 Bid PriceAcre Managing Field Office none provided Surface Manager COCONINO NF Lessee 1 HUNT W H...

  15. AZA-009175 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    (40 Acres) Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 2190 Bid PriceAcre Managing Field Office none provided Surface Manager COCONINO NF Lessee 1 HUNT W H...

  16. NVN-079305 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    1 Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1811.109 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

  17. NVN-079104 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2480.99 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 ORNI 16...

  18. NVN-080086 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Acres) Case Status Authorized Case Type GEOLEASENONCOMPETITI Total Acreage 650.32 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 NGP BLUE...

  19. NVN-079306 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    B Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2140.53 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

  20. Submission Format for IMS2004 (Title in 18-point Times font)

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    ... This property can vary significantly with module technology and design. SMA estimated the parasitic capacitance of wet silicon PV arrays to be 60-110 nF per kW and wet thin film ...

  1. NVN-080159 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 NGP BLUE MOUNTAIN I LLC Lessee 2 none provided Effective Date 7312016 Expire Date Held By...

  2. CACA-014407 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Acres) Case Status Authorized Case Type GEOLSECOMPPRE2005 Total Acreage 2561.25 Bid PriceAcre Managing Field Office none provided Surface Manager INYO NF Lessee 1 ORNI 51 LLC...

  3. NVN-079105 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2356.36 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 ORNI 16...

  4. Lattice QCD gauge ensemble: USQCD/MILC/asqtad/2064f21b678m010m050

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Aubin, Christopher Alan [Fordham U.; Bernard, Claude W. [Washington U. St. Louis; Burch, Tommy [U. Regensburg; Datta, Saumen [Tata Institute; DeGrand, Thomas Alan [Colorado U., Boulder; DeTar, Carleton E. [Utah U.; Gottlieb, Steven A. [Indiana U., Bloomington; Gregory, Eric Brittain [Wuppertal U.; Heller, Urs M. [American Physical Society; Hetrick, James Edward [U. Pacific, Stockton; Orginos, Kostas Nikolaou [William-Mary Coll.; Osborn, James C. [Argonne National Laboratory, ALCF; Toussaint, W. Doug [Arizona U.; Sugar, Robert L. [U. C., Santa Barbara

    MILC asqtad QCD SU(3) gauge ensemble; series=a; a=0.11fm minus 0.0022fm ; Ls=2.16fm; Nf=2+1; u0.m0=(0.010,0.050)

  5. Lattice QCD gauge ensemble: USQCD/MILC/asqtad/2064f21b678m010m050b

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Aubin, Christopher Alan [Fordham U.; Bernard, Claude W. [Washington U. St. Louis; Burch, Tommy [U. Regensburg; Datta, Saumen [Tata Institute; DeGrand, Thomas Alan [Colorado U., Boulder; DeTar, Carleton E. [Utah U.; Gottlieb, Steven A. [Indiana U., Bloomington; Gregory, Eric Brittain [Wuppertal U.; Heller, Urs M. [American Physical Society; Hetrick, James Edward [U. Pacific, Stockton; Orginos, Kostas Nikolaou [William-Mary Coll.; Osborn, James C. [Argonne National Laboratory, ALCF; Toussaint, W. Doug [Arizona U.; Sugar, Robert L. [U. C., Santa Barbara

    MILC asqtad QCD SU(3) gauge ensemble; series=b; a=0.11fm minus 0.0022fm; Ls=2.16fm; Nf=2+1; u0.m0=(0.010,0.050)

  6. AZA-009191 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    PriceAcre Managing Field Office none provided Surface Manager COCONINO NF Lessee 1 HUNT OIL USA INC Lessee 2 none provided Effective Date Expire Date Held By Production (HBP) HBP...

  7. AZA-009190 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    PriceAcre Managing Field Office none provided Surface Manager COCONINO NF Lessee 1 HUNT OIL USA INC Lessee 2 none provided Effective Date Expire Date Held By Production (HBP) HBP...

  8. AZA-009186 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    PriceAcre Managing Field Office none provided Surface Manager COCONINO NF Lessee 1 HUNT OIL USA INC Lessee 2 none provided Effective Date Expire Date Held By Production (HBP) HBP...

  9. YEAR

    National Nuclear Security Administration (NNSA)

    300 YEAR 2011 Males 109 Females 191 YEAR 2011 SES 9 EJEK 1 NN (Engineering) 2 NQ (ProfTechAdmin) 203 NU (TechAdmin Support) 38 NF (Future Ldrs) 47 YEAR 2011 American Indian...

  10. YEAR

    National Nuclear Security Administration (NNSA)

    86 YEAR 2012 Males 103 Females 183 YEAR 2012 SES 7 EJEK 1 NN (Engineering) 1 NQ (ProfTechAdmin) 202 NU (TechAdmin Support) 30 NF (Future Ldrs) 45 YEAR 2012 American Indian Male...

  11. Subject:

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    rotation reversals, poloidal impurity asymmetries and "non-local" heat transport Gao thesis 2015, Rice NF 2013). We are not yet certain if our RF L-mode target plasmas will...

  12. Lattice QCD gauge ensemble: USQCD/MILC/asqtad/2064f21b678m010m050b

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Aubin, Christopher Alan [Fordham U.; Bernard, Claude W. [Washington U. St. Louis; Burch, Tommy [U. Regensburg; Datta, Saumen [Tata Institute; DeGrand, Thomas Alan [Colorado U., Boulder; DeTar, Carleton E. [Utah U.; Gottlieb, Steven A. [Indiana U., Bloomington; Gregory, Eric Brittain [Wuppertal U.; Heller, Urs M. [American Physical Society; Hetrick, James Edward [U. Pacific, Stockton; Orginos, Kostas Nikolaou [William-Mary Coll.; Osborn, James C. [Argonne National Laboratory, ALCF; Toussaint, W. Doug [Arizona U.; Sugar, Robert L. [U. C., Santa Barbara

    2015-01-01

    MILC asqtad QCD SU(3) gauge ensemble; series=b; a=0.11fm minus 0.0022fm; Ls=2.16fm; Nf=2+1; u0.m0=(0.010,0.050)

  13. Lattice QCD gauge ensemble: USQCD/MILC/asqtad/2064f21b678m010m050

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Aubin, Christopher Alan [Fordham U.; Bernard, Claude W. [Washington U. St. Louis; Burch, Tommy [U. Regensburg; Datta, Saumen [Tata Institute; DeGrand, Thomas Alan [Colorado U., Boulder; DeTar, Carleton E. [Utah U.; Gottlieb, Steven A. [Indiana U., Bloomington; Gregory, Eric Brittain [Wuppertal U.; Heller, Urs M. [American Physical Society; Hetrick, James Edward [U. Pacific, Stockton; Orginos, Kostas Nikolaou [William-Mary Coll.; Osborn, James C. [Argonne National Laboratory, ALCF; Toussaint, W. Doug [Arizona U.; Sugar, Robert L. [U. C., Santa Barbara

    2015-01-01

    MILC asqtad QCD SU(3) gauge ensemble; series=a; a=0.11fm minus 0.0022fm ; Ls=2.16fm; Nf=2+1; u0.m0=(0.010,0.050)

  14. 1992 CBECS C & E

    U.S. Energy Information Administration (EIA) (indexed site)

    of Natural Gas by End Use, 1989 Natural Gas Consumption (trillion Btu) Space Water a Total Heating Heating Cooking Other RSE Building Row Characteristics Factor 1.0 NF...

  15. CACA-011667 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Surface Manager INYO NF Lessee 1 MAMMOTH-PACIFIC LP Lessee 2 none provided Effective Date 311982 Expire Date Held By Production (HBP) HELD BY PROD-Actual HBP Date 12221990...

  16. NVN-079291 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Manager TOIYABE NF Lessee 1 GRADIENT RESOURCES INC Lessee 2 none provided Effective Date 612006 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action...

  17. NVN-079666 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Manager TOIYABE NF Lessee 1 GRADIENT RESOURCES INC Lessee 2 none provided Effective Date 712005 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action...

  18. NVN-078688 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Manager TOIYABE NF Lessee 1 REESE RIVER GEO POWER LLC Lessee 2 none provided Effective Date 1012004 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action...

  19. NVN-079665 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Manager TOIYABE NF Lessee 1 GRADIENT RESOURCES INC Lessee 2 none provided Effective Date 712005 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action...

  20. NVN-079307 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Manager TOIYABE NF Lessee 1 GRADIENT RESOURCES INC Lessee 2 none provided Effective Date 712006 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action...

  1. NVN-079106 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Surface Manager TOIYABE NF Lessee 1 ORNI 16 LLC Lessee 2 none provided Effective Date 912006 Expire Date Held By Production (HBP) HBP Date RoyaltyRate 10% - 5% - 5% Most...

  2. NVN-077647 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Manager TOIYABE NF Lessee 1 GRADIENT RESOURCES INC Lessee 2 none provided Effective Date 612006 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action...

  3. NVN-079662 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Manager TOIYABE NF Lessee 1 GRADIENT RESOURCES INC Lessee 2 none provided Effective Date 6302015 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action...

  4. NVN-074249 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Manager TOIYABE NF Lessee 1 GRADIENT RESOURCES INC Lessee 2 none provided Effective Date 912007 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action...

  5. NVN-079663 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Manager TOIYABE NF Lessee 1 GRADIENT RESOURCES INC Lessee 2 none provided Effective Date 712005 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action...

  6. CACA-011672 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    provided Surface Manager INYO NF Lessee 1 ORNI 10 LLC Lessee 2 none provided Effective Date 111982 Expire Date Held By Production (HBP) HELD BY PROD-Actual HBP Date 12311998...

  7. NVN-078687 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Manager TOIYABE NF Lessee 1 REESE RIVER GEO POWER LLC Lessee 2 none provided Effective Date 1012004 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action...

  8. NVN-079668 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Manager TOIYABE NF Lessee 1 GRADIENT RESOURCES INC Lessee 2 none provided Effective Date 712005 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action...

  9. CACA-014408 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Surface Manager INYO NF Lessee 1 MAMMOTH-PACIFIC LP Lessee 2 none provided Effective Date 7191983 Expire Date Held By Production (HBP) HELD BY PROD-Actual HBP Date 782006...

  10. Altered expression of the IQGAP1 gene in human lung cancer cell lines

    SciTech Connect (OSTI)

    Mitchell, C.E.; Palmisano, W.A.; Lechner, J.F.

    1995-12-01

    IQGAP1 is a GTPase activation protein that accelerates GTP hydrolysis by normal p21 ras proteins. Therefore, IQGAP1 could act as an upstream affector of p21 ras activity by convert in excess amounts of active GTP-21 ras to inactive GDP-21 ras. IQGAP1 displays extensive sequence similarity to the catalytic domain of all previously reported ras GAPs, including the tumor suppressor gene protein neurofibromatosis type 1 (NF1). It has been shown that abnormal NF1 protein cannot negatively regulate the activity of ras proteins in neuroblast cells. This observation supports the hypothesis that NF1 is a tumor suppressor gene whose product acts upstream of ras. IQGAP1 is primarily expressed in lung, where it may play a role similar to NF1 in regulating the activity of H-ras or K-ras proteins. IQGAP1 functions as other GAPs by controlling the activity of ras.

  11. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    ... Lam, Amy Y. (1) Lamothe, Betty (1) Lin, Su-Chang (1) Lo, Yu-Chih (1) Min, Tongpil (1) ... of the NF-B Inhibitor A20 Lin, Su-Chang ; Chung, Jee Y. ; Lamothe, Betty ; ...

  12. Nucleophilic fluorination of aromatic compounds

    DOE Patents [OSTI]

    Satyamurthy, Nagichettiar; Barrio, Jorge R

    2014-03-18

    Iodylbenzene derivatives substituted with electron donating as well as electron withdrawing groups on the aromatic ring are used as precursors in aromatic nucleophilic substitution reactions. The iodyl group (IO.sub.2) is regiospecifically substituted by nucleophilic fluoride to provide the corresponding fluoroaryl derivatives. No-carrier-added [F-18]fluoride ion derived from anhydrous [F-18](F/Kryptofix, [F-18]CsF or a quaternary ammonium fluoride (e.g., Me.sub.4NF, Et.sub.4NF, n-Bu.sub.4NF, (PhCH.sub.2).sub.4NF) exclusively substitutes the iodyl moiety in these derivatives and provides high specific activity F-18 labeled fluoroaryl analogs. Iodyl derivatives of a benzothiazole analog and 6-iodyl-L-dopa derivatives have been synthesized as precursors and have been used in the preparation of no-carrier-added [F-18]fluorobenzothiazole as well as 6-[F-18]fluoro-L-dopa.

  13. Structural studies of magnesium nitride fluorides by powder neutron diffraction

    SciTech Connect (OSTI)

    Brogan, Michael A.; Hughes, Robert W.; Smith, Ronald I.; Gregory, Duncan H.

    2012-01-15

    Samples of ternary nitride fluorides, Mg{sub 3}NF{sub 3} and Mg{sub 2}NF have been prepared by solid state reaction of Mg{sub 3}N{sub 2} and MgF{sub 2} at 1323-1423 K and investigated by powder X-ray and powder neutron diffraction techniques. Mg{sub 3}NF{sub 3} is cubic (space group: Pm3m) and has a structure related to rock-salt MgO, but with one cation site vacant. Mg{sub 2}NF is tetragonal (space group: I4{sub 1}/amd) and has an anti-LiFeO{sub 2} related structure. Both compounds are essentially ionic and form structures in which nitride and fluoride anions are crystallographically ordered. The nitride fluorides show temperature independent paramagnetic behaviour between 5 and 300 K. - Graphical abstract: Definitive structures of the ternary magnesium nitride fluorides Mg{sub 3}NF{sub 3} and the lower temperature polymorph of Mg{sub 2}NF have been determined from powder neutron diffraction data. The nitride halides are essentially ionic and exhibit weak temperature independent paramagnetic behaviour. Highlights: Black-Right-Pointing-Pointer Definitive structures of Mg{sub 3}NF{sub 3} and Mg{sub 2}NF were determined by neutron diffraction. Black-Right-Pointing-Pointer Nitride and fluoride anions are crystallographically ordered in both structures. Black-Right-Pointing-Pointer Both compounds exhibit weak, temperature independent paramagnetic behaviour. Black-Right-Pointing-Pointer The compounds are essentially ionic with ionicity increasing with F{sup -} content.

  14. Comparative evaluations of the weldability of modified 800H and other advanced austenitic stainless steels

    SciTech Connect (OSTI)

    Lundin, C.D.; Qiao, C.Y.P.

    1993-07-01

    The weldability of modified 800H was evaluated in terms of HAZ hot cracking susceptibility and HAZ softening tendency. Four other types of austenitic alloys, modified 316, 310Ta, HR3C and NF709, were employed to carry out a comparative study. It was found that modified 800H exhibits good weldability in terms of operability as contrasted to NF709. However, a higher HAZ hot cracking susceptibility for the modified 800H tubing heats was revealed as compared to the commercial tubing heats of HR3C and NF709. The hot cracking test results for the small laboratory prepared modified 800H heats showed an equivalent or better HAZ hot cracking resistance as compared to HR3C and NF709. Thus, it is anticipated that modified 800H tubing can show a hot cracking resistance equivalent to NF709 and HR3C if the base metal grain size is properly controlled and an optimum thermal mechanical treatment has been performed. The preliminary assessment on HAZ softening behavior for modified 800H, modified 316, 310Ta, HR3C and NF709 alloys is discussed.

  15. Incorporating ecological risk assessment into remedial investigation/feasibility study work plans

    SciTech Connect (OSTI)

    Not Available

    1994-06-01

    This guidance document (1) provides instructions on preparing the components of an ecological work plan to complement the overall site remedial investigation/feasibility study (RI/FS) work plan and (2) directs the user on how to implement ecological tasks identified in the plan. Under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA), as amended by the Superfund Amendments and Reauthorization Act of 1986 (SARA), and RI/FS work plan will have to be developed as part of the site-remediation scoping process. Specific guidance on the RI/FS process and the preparation of work plans has been developed by the US Environmental Protection Agency (EPA 1988a). This document provides guidance to US Department of Energy (DOE) staff and contractor personnel for incorporation of ecological information into environmental remediation planning and decision making at CERCLA sites.

  16. Mode Selective Excitation Using Coherent Control Spectroscopy

    SciTech Connect (OSTI)

    Singh, Ajay K.; Konradi, Jakow; Materny, Arnulf; Sarkar, Sisir K.

    2008-11-14

    Femtosecond time-resolved coherent anti-Stokes Raman scattering (fs-CARS) gives access to ultrafast molecular dynamics. However, femtosecond laser pulses are spectrally broad and therefore coherently excite several molecular modes. While the temporal resolution is high, usually no mode-selective excitation is possible. This paper demonstrates the feasibility of selectively exciting specific molecular vibrations in solution phase with shaped fs laser excitation using a feedback-controlled optimization technique guided by an evolutionary algorithm. This approach is also used to obtain molecule-specific CARS spectra from a mixture of different substances. The optimized phase structures of the fs pulses are characterized to get insight into the control process. Possible applications of the spectrum control are discussed.

  17. Fine tunable red-green upconversion luminescence from glass ceramic containing 5%Er{sup 3+}:NaYF{sub 4} nanocrystals under excitation of two near infrared femtosecond lasers

    SciTech Connect (OSTI)

    Shang, Xiaoying; Cheng, Wenjing; Zhou, Kan; Ma, Jing; Feng, Donghai; Zhang, Shian; Sun, Zhenrong; Jia, Tianqing; Chen, Ping; Qiu, Jianrong

    2014-08-14

    In this paper, we report fine tunable red-green upconversion luminescence of glass ceramic containing 5%Er{sup 3+}: NaYF{sub 4} nanocrystals excited simultaneously by two near infrared femtosecond lasers. When the glass ceramic was irradiated by 800 nm femtosecond laser, weak red emission centered at 670 nm was detected. Bright red light was observed when the fs laser wavelength was tuned to 1490 nm. However, when excited by the two fs lasers simultaneously, the sample emitted bright green light centered at 550 nm, while the red light kept the same intensity. The dependences of the red and the green light intensities on the two pump lasers are much different, which enables us to manipulate the color emission by adjusting the two pump laser intensities, respectively. We present a theoretical model of Er{sup 3+} ions interacting with two fs laser fields, and explain well the experimental results.

  18. 12_02_1990.tex

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    from (1990AJ01): Energy levels of 12 B a E x in 12 B J π ; T τ or Γ c.m. (keV) Decay Reactions (MeV ± keV) 0 1 + ; 1 τ 1/2 = 20.20 ± 0.02 ms β - 1, 2, 5, 6, 8, 9, 12, 13, 14, 15, 16, 17, 18, 19, 20, 22, 23, 24, 25, 26, 27, 28 0.95314 ± 0.60 2 + τ m = 260 ± 40 fs γ 2, 5, 6, 8, 12, 13, 15, 18, 19, 23, 24, 25, 26, 27, 28 1.67365 ± 0.60 2 - < 50 fs γ 2, 5, 6, 8, 12, 13, 15, 18, 19, 23, 24, 25, 26 2.6208 ± 1.2 1 - < 70 fs γ 2, 6, 8, 12, 13, 15, 19, 24, 26 2.723 ± 11 0 + γ 2,

  19. Imaging the ultrafast Kerr effect, free carrier generation, relaxation and ablation dynamics of Lithium Niobate irradiated with femtosecond laser pulses

    SciTech Connect (OSTI)

    Garcia-Lechuga, Mario, E-mail: mario@io.cfmac.csic.es; Siegel, Jan, E-mail: j.siegel@io.cfmac.csic.es; Hernandez-Rueda, Javier; Solis, Javier [Laser Processing Group, Instituto de Optica, CSIC, Serrano 121, 28006 Madrid (Spain)

    2014-09-21

    The interaction of high-power single 130 femtosecond (fs) laser pulses with the surface of Lithium Niobate is experimentally investigated in this work. The use of fs-resolution time-resolved microscopy allows us to separately observe the instantaneous optical Kerr effect induced by the pulse and the generation of a free electron plasma. The maximum electron density is reached 550 fs after the peak of the Kerr effect, confirming the presence of a delayed carrier generation mechanism. We have also observed the appearance of transient Newton rings during the ablation process, related to optical interference of the probe beam reflected at the front and back surface of the ablating layer. Finally, we have analyzed the dynamics of the photorefractive effect on a much longer time scale by measuring the evolution of the transmittance of the irradiated area for different fluences below the ablation threshold.

  20. Removal of Pu238 from Neptunium Solution by Anion Exchange

    SciTech Connect (OSTI)

    KYSER, EDWARD

    2003-12-01

    A new anion flowsheet for use in HB-Line was tested in the lab with Reillex{trademark} HPQ for removal of Pu{sup 238} contamination from Np. Significant rejection of Pu{sup 238} was observed by washing with 6 to 12 bed volumes (BV) of reductive wash containing reduced nitric acid concentration along with both ferrous sulfamate (FS) and hydrazine. A shortened-height column was utilized in these tests to match changes in the plant equipment. Lab experiments scaled to plant batch sizes of 1500 to 2200 g Np were observed with modest losses for up-flow washing. Down-flow washing was observed to have high losses. The following are recommended conditions for removing Pu{sup 238} from Np solutions by anion exchange in HB-Line: (1) Feed conditions: Up-flow 6.4-8 M HNO{sub 3}, 0.02 M hydrazine, 0.05 M excess FS, less than 5 days storage of solution after FS addition. (2) Reductive Wash conditions: Up-flow 6-12 BV of 6.4 M HNO{sub 3}, 0.05 M FS, 0.05 M hydrazine. 1.8 mL/min/cm{sup 2} flowrate. (3) Decontamination Wash conditions: Up-flow 1-2 BV of 6.4-8 M HNO{sub 3}, no FS, no hydrazine. (4) Elution conditions: Down-flow 0.17 M HNO{sub 3}, 0.05 M hydrazine, no FS.

  1. Slide 1

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Disposal Practices over the Years 1955 1961 2004 1955 1961 20 1955 1961 SESSION 6: REGULATORY PROCESS Nick Ceto U.S. DOE - RL 2 RCRA/CERCLA Process * Tri-Parties have reached a Tentative Agreement for new TPA Milestones that include 200-SW-2 OU. 200-SW-2 will continue as a stand alone Operable Unit for the purpose of investigation and remedy selection. - M-015-93A: Submit revised RFI/CMS/RI/FS 1 Work Plan for the 200-SW- 2 OU to Ecology by 12/31/2011 - M-015-93B: Submit RFI/CMS /RI/FS Report and

  2. Calendar Year 2014 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    4 Calendar Year 2014 December 17, 2014 Audit Report: OAS-FS-15-05 Federal Energy Regulatory Commission's Fiscal Year 2014 Financial Statement Audit December 16, 2014 Inspection Report: DOE/IG-0929 Allegations Regarding the Consolidation of Central Alarm Stations at the Oak Ridge Reservation December 16, 2014 Audit Report: DOE/IG-0930 Follow-up on the Los Alamos National Laboratory Hydrodynamic Test Program December 15, 2014 Audit Report: OAS-FS-15-04 Management Letter on the Western Federal

  3. Quantum process tomography by 2D fluorescence spectroscopy

    SciTech Connect (OSTI)

    Pachón, Leonardo A.; Marcus, Andrew H.; Aspuru-Guzik, Alán

    2015-06-07

    Reconstruction of the dynamics (quantum process tomography) of the single-exciton manifold in energy transfer systems is proposed here on the basis of two-dimensional fluorescence spectroscopy (2D-FS) with phase-modulation. The quantum-process-tomography protocol introduced here benefits from, e.g., the sensitivity enhancement ascribed to 2D-FS. Although the isotropically averaged spectroscopic signals depend on the quantum yield parameter Γ of the doubly excited-exciton manifold, it is shown that the reconstruction of the dynamics is insensitive to this parameter. Applications to foundational and applied problems, as well as further extensions, are discussed.

  4. Final DOE Areas Feasibility Study, Appendices A - F

    Office of Legacy Management (LM)

    DOE Areas Feasibility Study Appendices LEHR CERCLA Completion Rev. 0 03/07/08 J:\DOE_STOLLER\4110\143\FEASIBILITY_STUDY\20080307_FS_TEXT_REV0.DOC WEISS ASSOCIATES Project Number: 130-4110-143 APPENDIX A COST ESTIMATES Final DOE Areas Feasibility Study Appendix A LEHR CERCLA Completion Rev. 0 03/07/08 Tables J:\DOE_Stoller\4110\143\Feasibility_Study\Rev0\Appendices\20080307_FS_APPA_tbls.doc Weiss Associates Project Number: 130-4110-143 Table A-1. Feasibility Study Cost Estimate Summaries Area/

  5. Final Supplemental Environmental Impact Statement for a Geologic Repository

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    for the Disposal of Spent Nuclear Fuel and High-Level Radioactive Waste at Yucca Mountain, Nye County, Nevada - Nevada Rail Transportation Corridor DOE/EIS-0250F-S2 and Final En | Department of Energy Final Supplemental Environmental Impact Statement for a Geologic Repository for the Disposal of Spent Nuclear Fuel and High-Level Radioactive Waste at Yucca Mountain, Nye County, Nevada - Nevada Rail Transportation Corridor DOE/EIS-0250F-S2 and Final En Final Supplemental Environmental Impact

  6. Direct imaging of rotational wave-packet dynamics of diatomic molecules

    SciTech Connect (OSTI)

    Dooley, P. W.; Lee, Kevin F.; Corkum, P. B.; Litvinyuk, I. V.; Rayner, D. M.; Villeneuve, D. M.; Spanner, M.

    2003-08-01

    We use linearly polarized 45 fs pulses to create rotational wave packets in N{sub 2} and O{sub 2}. We Coulomb explode molecules with a high-intensity circularly polarized pulse and use an ion imaging detector to measure a series of two-dimensional projections of the wave packet's angular distribution in 27 fs increments. We highlight the evolving wave packet near the first, second, sixth, and tenth full revival times and also near the one-eighth, one-quarter, one-half, and three-quarter fractional revivals.

  7. Most people are familiar with the effect of a camera, of capturing an instant in time

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Ultrashort Flashes of X-rays and Electrons at SLAC Fig. 1. (top) Time-resolved diffracted in- tensity for both (111) (top) and (220) (bottom) reflections. Red curves are Gaussian fits to the data, corresponding to 10-90 % fall times of 430 fs and 280 fs respectively. (inset) Fluence dependence of (111) time constant. Since the development of the laser researchers have been using it as a stroboscopic tool to observe how the world works. Research and development efforts leading towards the Linac

  8. Audits - Carlsbad Field Office (CBFO) Management Procedure (MP) 10.3, Rev.

    Office of Environmental Management (EM)

    B-95-02 Audit Report: AP-B-95-02 July 31, 1995 Audit of Selected Aspects of the Unclassified Computer Security Program at a DOE Headquarters Computing Facility Audit Report: AP-B-95-02 (77.9 KB) More Documents & Publications Evaluation Report on The Department's Unclassified Cyber Security Program 2002, DOE/IG-0567 Audit Report: IG-0818 Excessing of Computers Used for Unclassified Controlled Information at the Idaho National Laboratory, IG-0755

    FS-97-02 Audit Report: AP-FS-97-02 June 6,

  9. mira_boot_camp_2016_harms_io

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    on Mira and Challenges of Portable I/O with Best Practices Scaling Your Science 2016 Kevin Harms - harms@alcf.anl.gov Venkat Vishwanath Phil Carns Rob Latham Storage vs Computation Trend 2 ASC Sequoia 20 PF/s Compute 500GB/s Storage ASCI Red Mira Mira I/O Infrastructure Overview 3 Infiniband QDR SAN Cooley Compute I/O Node mira-fs0 (GPFS) mira-fs1 (GPFS) mira-home (GPFS) Infiniband FDR Cetus Storage resources Mira I/O Infrastructure 4 BG/Q Optical 2x16 Gbit/sec QDR InfiniBand 32 Gbit/sec Serial

  10. BIGHORN SHEEP: SUPPLEMENTAL ANALYSIS TO THE FOREST PLAN ENVIRONMENTAL IMPACT STATEMENT„INTERDISCIPLINARY TEAM MEETING

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    4/9/13 Page 1 of 2 RIVER AND PLATEAU COMMITTEE - 3 MONTH WORK PLAN (SUBJECT TO REVISION) May Committee meeting placeholder: Tuesday, May 7 Committee call placeholder: Tuesday, May 14 @ 1:30 p.m. * Advice development for the 300 Area RI/FS and Proposed Plan Rev 0 * Advice development for 100-F Area RI/FS and Proposed Plan Draft A * Impacts from the TC&WM EIS groundwater modeling on future cleanup proposals * Advice responses? * Committee Business June Committee meeting placeholder: Tuesday,

  11. LCLS CDR Appendix A - Parameter Tables

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    A Parameter Tables A.1 FEL-Physics A.1.1 Performance A.1.1.1 Electron Beam Parameter Name Low Energy High Energy All Energies Unit Electron energy 4.54 14.35 GeV Electron Lorentz factor 8880 28082 Normalized slice emittance 1.2 1.2 µm rad Charge at undulator entrance 1 1 nC Peak current 3400 3400 A Longitudinal pulse form Flat-Top Transverse pulse form Gaussian RMS bunch length 23 23 µm RMS bunch duration 77 77 fs FWHM bunch length 69 69 µm FWHM bunch duration 230 230 fs Slice rms gamma

  12. Life Cycle Nitrogen Trifluoride Emissions from Photovoltaics

    SciTech Connect (OSTI)

    Fthenakis, V.

    2010-10-25

    Amorphous- and nanocrystalline-silicon thin-film photovoltaic modules are made in high-throughput manufacturing lines that necessitate quickly cleaning the reactor. Using NF{sub 3}, a potent greenhouse gas, as the cleaning agent triggered concerns as recent reports reveal that the atmospheric concentrations of this gas have increased significantly. We quantified the life-cycle emissions of NF{sub 3} in photovoltaic (PV) manufacturing, on the basis of actual measurements at the facilities of a major producer of NF{sub 3} and of a manufacturer of PV end-use equipment. From these, we defined the best practices and technologies that are the most likely to keep worldwide atmospheric concentrations of NF{sub 3} at very low radiative forcing levels. For the average U.S. insolation and electricity-grid conditions, the greenhouse gas (GHG) emissions from manufacturing and using NF{sub 3} in current PV a-Si and tandem a-Si/nc-Si facilities add 2 and 7 g CO{sub 2eq}/kWh, which can be displaced within the first 1-4 months of the PV system life.

  13. 100-K Target Analyte List Development for Soil

    SciTech Connect (OSTI)

    Ovink, R.

    2012-09-18

    This report documents the process used to identify source area target analytes in support of the 100-K Area remedial investigation/feasibility study (RI/FS) addendum to the Integrated 100 Area Remedial Investigation/Feasibility Study Work Plan (DOE/RL-2008-46, Rev. 0).

  14. 100-F Target Analyte List Development for Soil

    SciTech Connect (OSTI)

    Ovink, R.

    2012-09-18

    This report documents the process used to identify source area target analytes in support of the 100-F Area remedial investigation/feasibility study (RI/FS) addendum to the Integrated 100 Area Remedial Investigation/Feasibility Study Work Plan (DOE/RL-2008-46, Rev. 0).

  15. 100-N Area Decision Unit Target Analyte List Development for Soil

    SciTech Connect (OSTI)

    Ovink, R.

    2012-09-18

    This report documents the process used to identify source area target analytes in support of the 100-N Area remedial investigation/feasibility study (RI/FS) addendum to the Integrated 100 Area Remedial Investigation/Feasibility Study Work Plan (DOE/RL-2008-46, Rev. 0).

  16. Audit Report: IG-0392 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    2 Audit Report: IG-0392 July 8, 1996 The Department of Energy Program Offices' Use of Management and Operating Contractor Employees Audit Report: IG-0392 (75.9 KB) More Documents & Publications Semiannual Report to Congress: October 1, 1995 - March 31, 1996 Semiannual Report to Congress: April 1, 1996 - September 30, 1996 Audit Report: IG-FS-96-01

  17. Audit Report: IG-0409 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    9 Audit Report: IG-0409 June 25, 1997 Audit of the Western Area Power Administration's Contract with Basin Electric Power Cooperative Audit Report: IG-0409 (62.48 KB) More Documents & Publications Semiannual Report to Congress: April 1 - September 30, 1997 Project Development and Finance Course Curriculum Terminology Guide Audit Report: OAI-FS-16-07

  18. Tri-Party Agreement Project Manager List by Milestone

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Milestone Page 1 of 11 September 9, 2016 Milestone EPA PM Ecology PM DOE PM Assistant ... L.C. Menard, N. Cline, M.W. Corey, R.J. EPA I Submit Rev'd FS Report & Rev'd PP for ...

  19. Nanostructure evolution in joining of Al and Fe nanoparticles with femtosecond laser irradiation

    SciTech Connect (OSTI)

    Jiao, Z.; Huang, H.; Zhou, Y. E-mail: nzhou@uwaterloo.ca; Liu, L.; Hu, A.; Duley, W.; He, P. E-mail: nzhou@uwaterloo.ca

    2014-04-07

    The joining of Al-Fe nanoparticles (NPs) by femtosecond (fs) laser irradiation is reported in this paper. Fe and Al NPs were deposited on a carbon film in vacuum via fs laser ablation. Particles were then exposed to multiple fs laser pulses at fluences between 0.5 and 1.3?mJ/cm{sup 2}. Transmission Electron Microscopy (TEM) and Electron Diffraction X-ray observations indicate that Al and Fe NPs bond to each other under these conditions. For comparison, bonding of Al to Al and Fe to Fe NPs was also investigated. The nanostructure, as observed using TEM, showed that individual Al NPs were monocrystalline while individual Fe NPs were polycrystalline prior to joining and that these structures are retained after the formation of Al-Al and Fe-Fe NPs. Al-Fe NPs produced by fs laser joining exhibited a mixed amorphous and crystalline phase at the interface. Bonding is suggested to originate from intermixing within a region of high field intensity between particles.

  20. Remedial investigation/feasibility study Work Plan and addenda for Operable Unit 4-12: Central Facilities Area Landfills II and III at the Idaho National Engineering Laboratory

    SciTech Connect (OSTI)

    Keck, K.N.; Stormberg, G.J.; Porro, I.; Sondrup, A.J.; McCormick, S.H.

    1993-07-01

    This document is divided into two main sections -- the Work Plan and the addenda. The Work Plan describes the regulatory history and physical setting of Operable Unit 4-12, previous sampling activities, and data. It also identifies a preliminary conceptual model, preliminary remedial action alternatives, and preliminary applicable or relevant and appropriate requirements. In addition, the Work Plan discusses data gaps and data quality objectives for proposed remedial investigation activities. Also included are tasks identified for the remedial investigation/feasibility study (RI/FS) and a schedule of RI/FS activities. The addenda include details of the proposed field activities (Field Sampling Plan), anticipated quality assurance activities (Quality Assurance Project Plan), policies and procedures to protect RI/FS workers and the environment during field investigations (Health and Safety Plan), and policies, procedures, and activities that the Department of Energy will use to involve the public in the decision-making process concerning CFA Landfills II and III RI/FS activities (Community Relations Plan).

  1. Toolkit Model for SN-03 Final Proposal (ratecases/sn03)

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Model SN CRAC ToolKit Model Variable, Flat SN CRAC, 80% TPP (TK187SN-03FS3BPA-PropVariableFlatSNN24-Jun-03.xls, 3.1 MB) Data Input Files (required to run the above...

  2. Waste Management Plan for the Oak Ridge National Remedial Investigation/Feasibility Study

    SciTech Connect (OSTI)

    Not Available

    1988-04-01

    In accordance with the requirements of the Remedial Investigation/Feasibility Study (RI/FS) Project Quality Assurance Plan, this Waste Management Plan establishes clear lines of responsibility and authority, documentation requirements, and operational guidance for the collection, identification, segregation, classification, packaging, certification, and storage/disposal of wastes. These subjects are discussed in the subsequent sections of this document.

  3. Polarization controlled deep sub-wavelength periodic features written by femtosecond laser on nanodiamond thin film surface

    SciTech Connect (OSTI)

    Kumar Kuntumalla, Mohan; Srikanth, Vadali V. S. S.; Rajamudili, Kuladeep; Rao Desai, Narayana

    2014-04-21

    Deep sub-wavelength (Λ/λ = ∼0.22) periodic features are induced uniformly on a nanodiamond (ND) thin film surface using femtosecond (fs) laser irradiation (pulse duration = ∼110 fs and central wavelength of ∼800 nm). The topography of the surface features is controlled by the laser polarization. Orientation of features is perpendicular to laser polarization. Periodicity (spatial periodicity of < λ/4) of the surface features is less than the laser wavelength. This work gives an experimental proof of polarization controlled surface plasmon-fs laser coupling mechanism prompting the interaction between fs laser and solid matter (here ND thin film) which in turn is resulting in the periodic surface features. Scanning electron microscopy in conjunction with micro Raman scattering, X-ray diffraction, and atomic force microscopy are carried out to extract surface morphology and phase information of the laser irradiated regions. This work demonstrates an easy and efficient surface fabrication technique.

  4. Identification of 300 Area Contaminants of Potential Concern for Soil

    SciTech Connect (OSTI)

    R.W. Ovink

    2010-04-05

    This report documents the process used to identify source area contaminants of potential concern (COPCs) in support of the 300 Area remedial investigation/feasibility study (RI/FS) work plan. This report also establishes the exclusion criteria applicable for 300 Area use and the analytical methods needed to analyze the COPCs.

  5. Radio frequency phototube and optical clock: High resolution, high rate and highly stable single photon timing technique

    SciTech Connect (OSTI)

    Margaryan, Amur

    2011-10-01

    A new timing technique for single photons based on the radio frequency phototube and optical clock or femtosecond optical frequency comb generator is proposed. The technique has a 20 ps resolution for single photons, is capable of operating with MHz frequencies and achieving 10 fs instability level.

  6. Semiannual Report to Congress: March 31, 1997 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    March 31, 1997 Semiannual Report to Congress: March 31, 1997 April 30, 1997 1997 Inspector General Semiannual Report to Congress Semiannual Report to Congress ending March 31, 1997 Semiannual Report to Congress: March 31, 1997 (172.46 KB) More Documents & Publications Inspection Report: INS-O-98-03 Inspection Report: IG-0401 Audit Report: WR-FS-97-04

  7. T-567: Linux Kernel Buffer Overflow in ldm_frag_add() May Let Local Users Gain Elevated Privileges

    Energy.gov [DOE]

    A vulnerability was reported in the Linux Kernel. A local user may be able to obtain elevated privileges on the target system. A physically local user can connect a storage device with a specially crafted LDM partition table to trigger a buffer overflow in the ldm_frag_add() function in 'fs/partitions/ldm.c' and potentially execute arbitrary code with elevated privileges.

  8. Ecological risk assessment guidance for preparation of remedial investigation/feasibility study work plans

    SciTech Connect (OSTI)

    Pentecost, E.D.; Vinikour, W.S.

    1993-08-01

    This guidance document (1) provides instructions on preparing the components of an ecological work plan to complement the overall site remedial assessment investigation/feasibility study (RI/FS) work plan and (2) directs the user on how to implement ecological tasks identified in the plan. Under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA), as amended by the Superfired Amendments and Reauthorization Act of 1986 (SARA), an RI/FS work plan win have to be developed as part of the site-remediation scoping the process. Specific guidance on the RI/FS process and the preparation of work plans has been developed by the US Environmental Protection Agency (EPA 1988a). This document provides guidance to US Department of Energy (DOE) staff and contractor personnel for incorporation of ecological information into environmental remediation planning and decision making at CERCLA sites. An overview analysis of early ecological risk assessment methods (i.e., in the 1980s) at Superfund sites was conducted by the EPA (1989a). That review provided a perspective of attention given to ecological issues in some of the first RI/FS studies. By itself, that reference is of somewhat limited value; it does, however, establish a basis for comparison of past practices in ecological risk with current, more refined methods.

  9. Type-I cascaded quadratic soliton compression in lithium niobate: Compressing femtosecond pulses from high-power fiber lasers

    SciTech Connect (OSTI)

    Bache, Morten; Wise, Frank W.

    2010-05-15

    The output pulses of a commercial high-power femtosecond fiber laser or amplifier are typically around 300-500 fs with wavelengths of approximately 1030 nm and tens of microjoules of pulse energy. Here, we present a numerical study of cascaded quadratic soliton compression of such pulses in LiNbO{sub 3} using second-harmonic generation in a type-I phase-matching configuration. We find that because of competing cubic material nonlinearities, compression can only occur in the nonstationary regime, where group-velocity-mismatch-induced Raman-like nonlocal effects prevent compression to less than 100 fs. However, the strong group-velocity dispersion implies that the pulses can achieve moderate compression to durations of less than 130 fs in available crystal lengths. Most of the pulse energy is conserved because the compression is moderate. The effects of diffraction and spatial walk-off are addressed, and in particular the latter could become an issue when compressing such long crystals (around 10 cm long). We finally show that the second harmonic contains a short pulse locked to the pump and a long multi-picosecond red-shifted detrimental component. The latter is caused by the nonlocal effects in the nonstationary regime, but because it is strongly red-shifted to a position that can be predicted, we show that it can be removed using a bandpass filter, leaving a visible component of less than 100 fs at {lambda}=515 nm with excellent pulse quality.

  10. Direct measurement of the characteristic three-body electron attachment time in the atmospheric air in direct current electric field

    SciTech Connect (OSTI)

    Shutov, A. V.; Smetanin, I. V.; Ionin, A. A.; Levchenko, A. O.; Seleznev, L. V.; Sinitsyn, D. V.; Ustinovskii, N. N.; Zvorykin, V. D.

    2013-07-15

    We report the results of theoretical and experimental study of the characteristic time for three-body attachment of electrons produced by 100 fs UV laser pulse in the atmosphere air in the external DC electric field ranged from 0.2 to 10 kV/cm.

  11. EIS-0303-SA-02-2014.pdf

    Energy Savers

    Energy : Final Environmental Impact Statement, Volume 2 EIS-0285: Final Environmental Impact Statement, Volume 2 Bonneville Power Administration Transmission System Vegetation Management Program Volume 2: Appendices Appendix A - Publications Appendix B - Biological Weed Control Agents Appendix C - Bonneville Pesticide Applicator Certification Plan Appendix D - Sample Educational Information Appendix E - Clearance Criteria Appendix F - FS Mitigation Measures and Background Appendix G - BLM

  12. Latent instabilities in metallic LaNiO₃ films by strain control of Fermi-surface topology

    SciTech Connect (OSTI)

    Yoo, Hyang Keun; Hyun, Seung Ill; Moreschini, Luca; Kim, Hyeong -Do; Chang, Young Jun; Sohn, Chang Hee; Jeong, Da Woon; Sinn, Soobin; Kim, Yong Su; Bostwick, Aaron; Rotenberg, Eli; Shim, Ji Hoon; Noh, Tae Won

    2015-03-04

    Strain control is one of the most promising avenues to search for new emergent phenomena in transition metal-oxide films. Here, we investigate the strain-induced changes of electronic structures in strongly correlated LaNiO₃ (LNO) films, using angle-resolved photoemission spectroscopy and the dynamical mean-field theory. The strongly renormalized eg-orbital bands are systematically rearranged by misfit strain to change its fermiology. As tensile strain increases, the hole pocket centered at the A point elongates along the kz-axis and seems to become open, thus changing Fermi-surface (FS) topology from three- to quasi-two-dimensional. Concomitantly, the FS shape becomes flattened to enhance FS nesting. A FS superstructure withQ₁ = (1/2,1/2,1/2) appears in all LNO films, while a tensile-strained LNO film has an additional Q₂ = (1/4,1/4,1/4) modulation, indicating that some instabilities are present in metallic LNO films. Charge disproportionation and spin-density-wave fluctuations observed in other nickelates might be their most probable origins

  13. Launch of fast reactor cycle technology development project in Japan

    SciTech Connect (OSTI)

    Sagayama, Yutaka

    2007-07-01

    Japan Atomic Energy Agency (JAEA launched a new Fast Reactor Cycle Technology Development f (FaCT) Project in cooperation with the Japanese electric utilities. The FaCT project is based on the conclusion of the previous project, namely the Feasibility Study on Commercialized Fast Reactor Cycle Systems (FS) which carried out in last seven years. In the FS, the combination of the sodium-cooled fast reactor with oxide fuel, the advanced aqueous reprocessing and the simplified pelletizing fuel fabrication was selected as the main concept which should be developed principally because it was the most promising concept for commercialization. A conceptual design study of the main concept and research and development of innovative technologies adopted in the main concept are implemented toward an important milestone at 2015. The development targets, which were set up at the beginning stage of FS, were revised for the FaCT project based on the results of FS and change in Japanese society environment and in the world situation. International collaboration is promoted to pursue fast reactor cycle technology which deserves the global standard and its efficient development. (author)

  14. Email Template

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    0 and 11, 2009 FINAL MEETING SUMMARY HANFORD ADVISORY BOARD RIVER AND PLATEAU COMMITTEE MEETING June 10 and June 11, 2009 Richland, WA Topics in this Meeting Summary Welcome and Introductions ................................................................................................ 1 Rehabilitation and Restoration of Fire-Impacted Areas ..................................................... 1 River Corridor CERCLA Decision Documents and Remedial Investigation and Feasibility Study (RI/FS)

  15. Geothermal Technologies Program Fact Sheet | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Fact Sheet Geothermal Technologies Program Fact Sheet Overview of DOE Geothermal Technologies Program. geothermal_fs.pdf (761.01 KB) More Documents & Publications Geothermal Technologies Program Peer Review Program June 6 - 10, 2011 Geothermal Technologies Program Overview Geothermal Technologies Program Multi-Year Research, Development and Demonstration Plan: Executive Summary

  16. Microsoft Word - HAB_2010_0616_RAP_FINAL.doc

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    6, 2010 FINAL MEETING SUMMARY HANFORD ADVISORY BOARD RIVER AND PLATEAU COMMITTEE MEETING June 16, 2010 Richland, WA Topics in this Meeting Summary Welcome and introductions ................................................................................................ 1 Comprehensive Land Use Plan (CULP) ............................................................................. 1 100-N Remedial Investigation/Feasibility Study (RI/FS) Work Plan Advice .................... 5 Action Items /

  17. Audit Report: IG-0370 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    70 Audit Report: IG-0370 March 29, 1995 Audit of Staffing Requirements for the Strategic Petroleum Reserve Audit Report: IG-0370 (166.67 KB) More Documents & Publications Inspection Report: INS-9502 LWZ-0026 - In the Matter of Boeing Petroleum Services, Inc. Audit Report: CR-FS-96

  18. Longer-term domestic supply problems for nonrenewable materials with special emphasis on energy-related applications

    SciTech Connect (OSTI)

    Goeller, H.E.

    1980-01-01

    An examination is made on how materials are used in present and future energy production and use. Problem areas which are discussed include by-products production, import limitations, substitution and recycle, accelerated use, synthesis, and the adequacy of the data bases availability. (FS)

  19. Table

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    1.0 fs 5, 7, 9, 14, 15, 19, 20, 23, 24, 25 5.2409 0.3 5 2 + 3.25 0.30 ps 4, 5, 6, 7, 9, 14, 15, 18, 19, 20, 23, 24, 25, 27 g +0.248 0.026 6.1763 1.7 3 2 -...

  20. 20_05_1998.tex

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    0.03 3 + m 440 30 fs 8, 9, 10, 12, 13, 14, 17, 24, 25, 27 0.82273 0.03 4 + m 79 6 ps 8, 9, 10, 12, 13, 14, 17, 24, 25, 27 0.98359 0.03 1 - m ...

  1. Streamtube Fate and Transport Modeling of the Source Term for the Old Radioactive Waste

    SciTech Connect (OSTI)

    Brewer, K.

    2000-11-16

    The modeling described in this report is an extension of previous fate and transport modeling for the Old Radioactive Waste Burial Ground Corrective Measures Study/Feasibility Study. The purpose of this and the previous modeling is to provide quantitative input to the screening of remedial alternatives for the CMS/FS for this site.

  2. Anomalous magnetic behavior in nanocomposite materials of reduced graphene oxide-Ni/NiFe{sub 2}O{sub 4}

    SciTech Connect (OSTI)

    Kollu, Pratap E-mail: anirmalagrace@vit.ac.in; Prathapani, Sateesh; Varaprasadarao, Eswara K.; Mallick, Sudhanshu; Bahadur, D. E-mail: anirmalagrace@vit.ac.in; Santosh, Chella; Grace, Andrews Nirmala E-mail: anirmalagrace@vit.ac.in

    2014-08-04

    Magnetic Reduced Graphene Oxide-Nickel/NiFe{sub 2}O{sub 4} (RGO-Ni/NF) nanocomposite has been synthesized by one pot solvothermal method. Respective phase formations and their purities in the composite are confirmed by High Resolution Transmission Electron Microscope and X Ray Diffraction, respectively. For the RGO-Ni/NF composite material finite-size effects lead to the anomalous magnetic behavior, which is corroborated in temperature and field dependent magnetization curves. Here, we are reporting the behavior of higher magnetization values for Zero Field Cooled condition to that of Field Cooled for the RGO-Ni/NF nanocomposite. Also, the observed negative and positive moments in Hysteresis loops at relatively smaller applied fields (100?Oe and 200?Oe) are explained on the basis of surface spin disorder.

  3. Propionic acid production by extractive fermentation. 1. Solvent considerations

    SciTech Connect (OSTI)

    Gu, Z.; Glatz, B.A.; Glatz, C.E.

    1998-02-20

    Solvent selection for extractive fermentation for propionic acid was conducted with three systems: Alamine{reg_sign} 304-1 (trilaurylamine) in 2-octanol, 1-dodecanol, and Witcohol{reg_sign} 85 NF (oleyl alcohol). Among them, the solvent containing 2-octanol exhibited the highest partition coefficient in acid extraction, but it was also toxic to propionibacteria. The most solvent-resistant strain among five strains of the microorganism was selected. Solvent toxicity was eliminated via two strategies: entrapment of dissolved toxic solvent in the culture growth medium with vegetable oils such as corn, olive, or soybean oils; or replacement of the toxic 2-octanol with nontoxic Witcohol 85 NF. The complete recovery of acids from the Alamine 304-1/Witcohol 85 NF was also realized with vacuum distillation.

  4. Effect of Fe2+ Oxidation on the Removal of 238Pu from Neptunium Solution by Anion Exchange

    SciTech Connect (OSTI)

    KYSER, EDWARD

    2004-06-01

    The effect of ferrous sulfamate (FS) oxidation and variation in nitric acid concentration on the removal of {sup 238}Pu contamination from Np by the HB-Line anion exchange flowsheet has been tested. Significant rejection of {sup 238}Pu was observed by washing with a reductive wash solution containing 6.0 to 6.8 M nitric acid (HNO{sub 3}) with as little as 30% of the Fe{sup 2+} from the FS remaining in its reduced form. To achieve the desired 30% removal of {sup 238}Pu from the process, conditions should be controlled to maintain the Fe{sup 2+}/Fe{sup 3+} ratio in the reductive wash to be greater than 60%/40% (or 1.5). Since Fe{sup 2+} oxidation is strongly affected by temperature and nitric acid concentration, these parameters (as well as time after FS addition) need to be controlled to ensure predictable results. A shortened-height column was utilized in these tests to match changes in the plant equipment. Lab experiments scaled to plant batch sizes of 2000 g Np were observed with modest losses for ''up-flow'' washing. The following are recommended conditions for removing {sup 238}Pu from Np solutions by anion exchange in HB-Line: (1) Feed conditions: ''Up-flow'' 6.4-8.0 M HNO{sub 3}, 0.02 M hydrazine (N{sub 2}H{sub 4}), 0.05 M excess FS. (2) Reductive Wash conditions: ''Up-flow'' 6 Bed volumes (BV) of 6.4 M HNO{sub 3}, 0.05 M FS (minimum 0.03M Fe{sup 2+} during wash cycle), 0.05 M hydrazine, less than 1.8 mL/min/cm{sup 2} flowrate. (3) Decontamination Wash conditions: ''Up-flow'' 1-2 BV of 6.4-8.0 M HNO{sub 3}, no FS, no hydrazine, less than 1.8 mL/min/cm{sup 2} flowrate. (4) Elution conditions: ''Down-flow'' 0.17 M HNO{sub 3}, 0.05 M hydrazine, no FS.

  5. Dynamics of plasma expansion and shockwave formation in femtosecond laser-ablated aluminum plumes in argon gas at atmospheric pressures

    SciTech Connect (OSTI)

    Miloshevsky, Alexander; Harilal, Sivanandan S.; Miloshevsky, Gennady Hassanein, Ahmed

    2014-04-15

    Plasma expansion with shockwave formation during laser ablation of materials in a background gasses is a complex process. The spatial and temporal evolution of pressure, temperature, density, and velocity fields is needed for its complete understanding. We have studied the expansion of femtosecond (fs) laser-ablated aluminum (Al) plumes in Argon (Ar) gas at 0.5 and 1 atmosphere (atm). The expansion of the plume is investigated experimentally using shadowgraphy and fast-gated imaging. The computational fluid dynamics (CFD) modeling is also carried out. The position of the shock front measured by shadowgraphy and fast-gated imaging is then compared to that obtained from the CFD modeling. The results from the three methods are found to be in good agreement, especially during the initial stage of plasma expansion. The computed time- and space-resolved fields of gas-dynamic parameters have provided valuable insights into the dynamics of plasma expansion and shockwave formation in fs-pulse ablated Al plumes in Ar gas at 0.5 and 1 atm. These results are compared to our previous data on nanosecond (ns) laser ablation of Al [S. S. Harilal et al., Phys. Plasmas 19, 083504 (2012)]. It is observed that both fs and ns plumes acquire a nearly spherical shape at the end of expansion in Ar gas at 1 atm. However, due to significantly lower pulse energy of the fs laser (5 mJ) compared to pulse energy of the ns laser (100 mJ) used in our studies, the values of pressure, temperature, mass density, and velocity are found to be smaller in the fs laser plume, and their time evolution occurs much faster on the same time scale. The oscillatory shock waves clearly visible in the ns plume are not observed in the internal region of the fs plume. These experimental and computational results provide a quantitative understanding of plasma expansion and shockwave formation in fs-pulse and ns-pulse laser ablated Al plumes in an ambient gas at atmospheric pressures.

  6. Analysis of Soluble Re Concentrations in Refractory from Bulk Vitrification Full-Scale Test 38B

    SciTech Connect (OSTI)

    Cooley, Scott K.; Pierce, Eric M.; Bagaasen, Larry M.; Schweiger, Michael J.

    2006-06-30

    The capacity of the waste treatment plant (WTP) being built at the Hanford Site is not sufficient to process all of the tank waste accumulated from more than 40 years of nuclear materials production. Bulk vitrification can accelerate tank waste treatment by providing some supplemental low-activity waste (LAW) treatment capacity. Bulk vitrification combines LAW and glass-forming chemicals in a large metal container and melts the contents using electrical resistance heating. A castable refractory block (CRB) is used along with sand to insulate the container from the heat generated while melting the contents into a glass waste form. This report describes engineering-scale (ES) and full-scale (FS) tests that have been conducted. Several ES tests showed that a small fraction of soluble Tc moves in the CRB and results in a groundwater peak different than WTP glass. The total soluble Tc-99 fraction in the FS CRB is expected to be different than that determined in the ES tests, but until FS test results are available, the best-estimate soluble Tc-99 fraction from the ES tests has been used as a conservative estimate. The first FS test results are from cold simulant tests that have been spiked with Re. An estimated scale-up factor extrapolates the Tc-99 data collected at the ES to the FS bulk vitrification waste package. Test FS-38A tested the refractory design and did not have a Re spike. Samples were taken and analyzed to help determine Re CRB background concentrations using a Re-spiked, six-tank composite simulant mixed with soil and glass formers to produce the waste feed. Although this feed is not physically the same as the Demonstration Bulk Vitrification System feed , the chemical make-up is the same. Extensive sampling of the CRB was planned, but difficulties with the test prevented completion of a full box. An abbreviated plan is described that looks at duplicate samples taken from refractory archive sections, a lower wall sample, and two base samples to gain early

  7. Bidimensional Particle-In-Cell simulations for laser-driven proton acceleration using ultra-short, ultra-high contrast laser

    SciTech Connect (OSTI)

    Scisciò, M.; Palumbo, L.; D'Humières, E.; Fourmaux, S.; Kieffer, J. C.; Antici, P.

    2014-12-15

    In this paper, we report on bi-dimensional Particle-In-Cell simulations performed in order to reproduce the laser-driven proton acceleration obtained when a commercial 200 TW Ti:Sa Laser hits a solid target. The laser-to prepulse contrast was enhanced using plasma mirrors yielding to a main-to-prepulse contrast of ∼10{sup 12}. We varied the pulse duration from 30 fs to 500 fs and the target thickness from 30 nm to several tens of μm. The on-target laser energy was up to 1.8 J leading to an intensity in excess of 10{sup 20 }W cm{sup −2}. A comparison between numerical and existing experimental data [S. Fourmaux et al., Phys. Plasmas 20, 013110 (2013)] is performed, showing a good agreement between experimental results and simulations which confirms that for ultra-thin targets there is an optimum expansion regime. This regime depends on the target thickness and on the laser intensity: if the target is too expanded, the laser travels through the target without being able to deposit its energy within the target. If the target is not sufficiently expanded, the laser energy is reflected by the target. It is important to note that maximum proton energies are reached at longer pulse durations (in the 100 fs regime) than what is currently the best compression pulse length for this type of lasers (typically 20–30 fs). This duration, around 50–100 fs, can be considered a minimum energy transfer time between hot electrons to ions during the considered acceleration process.

  8. Report on thermal aging effects on tensile properties of ferritic-martensitic steels.

    SciTech Connect (OSTI)

    Li, M.; Soppet, W.K.; Rink, D.L.; Listwan, J.T.; Natesan, K.

    2012-05-10

    This report provides an update on the evaluation of thermal-aging induced degradation of tensile properties of advanced ferritic-martensitic steels. The report is the first deliverable (level 3) in FY11 (M3A11AN04030103), under the Work Package A-11AN040301, 'Advanced Alloy Testing' performed by Argonne National Laboratory, as part of Advanced Structural Materials Program for the Advanced Reactor Concepts. This work package supports the advanced structural materials development by providing tensile data on aged alloys and a mechanistic model, validated by experiments, with a predictive capability on long-term performance. The scope of work is to evaluate the effect of thermal aging on the tensile properties of advanced alloys such as ferritic-martensitic steels, mod.9Cr-1Mo, NF616, and advanced austenitic stainless steel, HT-UPS. The aging experiments have been conducted over a temperature of 550-750 C for various time periods to simulate the microstructural changes in the alloys as a function of time at temperature. In addition, a mechanistic model based on thermodynamics and kinetics has been used to address the changes in microstructure of the alloys as a function of time and temperature, which is developed in the companion work package at ANL. The focus of this project is advanced alloy testing and understanding the effects of long-term thermal aging on the tensile properties. Advanced materials examined in this project include ferritic-martensitic steels mod.9Cr-1Mo and NF616, and austenitic steel, HT-UPS. The report summarizes the tensile testing results of thermally-aged mod.9Cr-1Mo, NF616 H1 and NF616 H2 ferritic-martensitic steels. NF616 H1 and NF616 H2 experienced different thermal-mechanical treatments before thermal aging experiments. NF616 H1 was normalized and tempered, and NF616 H2 was normalized and tempered and cold-rolled. By examining these two heats, we evaluated the effects of thermal-mechanical treatments on material microstructures and

  9. ALL GRADE 5 AND GRADE 8 FASTENERS WHICH DO NOT BEAR ANY MANUFACTURERS'

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ALL GRADE 5 AND GRADE 8 FASTENERS WHICH DO NOT BEAR ANY MANUFACTURERS' HEADMARKS Grade 5 Grade 8 GRADE 5 FASTENERS WITH THE FOLLOWING MANUFACTURERS' HEADMARKS: GRADE 8 FASTENERS WITH THE FOLLOWING MANUFACTURERS' HEADMARKS: MARK KS MARK J (CA TW JP YU) (Greater than 1/2 inch dia) MARK A NF H M MS Hollow Triangle E MARK KS RT FM KY J UNY A KS RT KY J UNY NF H M MS E FM GRADE 8.2 FASTENERS WITH THE FOLLOWING HEADMARKS: MARK KS KS J KS GRADE A325 FASTENERS WITH THE FOLLOWING HEADMARKS: MARK A325 KS

  10. Consider nanofiltration for membrane separations

    SciTech Connect (OSTI)

    Raman, L.P. ); Cheryna, M.; Rajagopalan, N. )

    1994-03-01

    The best known liquid-phase membrane processes are reverse osmosis (RO), ultrafiltration (UF), microfiltration (MF), dialysis, and electrodialysis (ED). However, over the past few years, a new membrane process called nanofiltration (NF) has emerged that promises to significantly widen the application of membranes in liquid-phase separations. This paper discusses the following: NF operating range, membrane properties, and the following applications: demineralizing water, cleaning up contaminated groundwater, ultrapure water, effluents containing heavy metals, offshore oil platforms, yeast production, pulp and paper mills, textile production, electroless copper plating, and cheese whey production.

  11. Nuclear factor-?B is a common upstream signal for growth differentiation factor-5 expression in brown adipocytes exposed to pro-inflammatory cytokines and palmitate

    SciTech Connect (OSTI)

    Hinoi, Eiichi; Iezaki, Takashi; Ozaki, Kakeru; Yoneda, Yukio

    2014-10-03

    Highlights: GDF5 expression is up-regulated by IL-1?, TNF-? and palmitate in brown pre-adipocytes. NF-?B stimulates promoter activity and expression of GDF5 in brown pre-adipocytes. Recruitment of NF-?B to the GDF5 promoter is facilitated in BAT from ob/ob mice. An NF-?B inhibitor prevents upregulation of GDF5 expression in brown pre-adipocytes. - Abstract: We have previously demonstrated that genetic and acquired obesity similarly led to drastic upregulation in brown adipose tissue (BAT), rather than white adipose tissue, of expression of both mRNA and corresponding protein for the bone morphogenic protein/growth differentiation factor (GDF) member GDF5 capable of promoting brown adipogenesis. In this study, we evaluated expression profiles of GDF5 in cultured murine brown pre-adipocytes exposed to pro-inflammatory cytokines and free fatty acids (FFAs), which are all shown to play a role in the pathogenesis of obesity. Both interleukin-1? (IL-1?) and tumor necrosis factor-? (TNF-?) were effective in up-regulating GDF5 expression in a concentration-dependent manner, while similar upregulation was seen in cells exposed to the saturated FFA palmitate, but not to the unsaturated FFA oleate. In silico analysis revealed existence of the putative nuclear factor-?B (NF-?B) binding site in the 5?-flanking region of mouse GDF5, whereas introduction of NF-?B subunits drastically facilitated both promoter activity and expression of GDF5 in brown pre-adipocytes. Chromatin immunoprecipitation analysis confirmed significant facilitation of the recruitment of NF-?B to the GDF5 promoter in lysed extracts of BAT from leptin-deficient ob/ob obese mice. Upregulation o GDF5 expression was invariably inhibited by an NF-?B inhibitor in cultured brown pre-adipocytes exposed to IL-1?, TNF-? and palmitate. These results suggest that obesity leads to upregulation of GDF5 expression responsible for the promotion of brown adipogenesis through a mechanism relevant to activation of the

  12. Use of nanofiltration to reduce cooling tower water consumption.

    SciTech Connect (OSTI)

    Altman, Susan Jeanne; Ciferno, Jared

    2010-10-01

    Nanofiltration (NF) can effectively treat cooling-tower water to reduce water consumption and maximize water usage efficiency of thermoelectric power plants. A pilot is being run to verify theoretical calculations. A side stream of water from a 900 gpm cooling tower is being treated by NF with the permeate returning to the cooling tower and the concentrate being discharged. The membrane efficiency is as high as over 50%. Salt rejection ranges from 77-97% with higher rejection for divalent ions. The pilot has demonstrated a reduction of makeup water of almost 20% and a reduction of discharge of over 50%.

  13. Use of nanofiltration to reduce cooling tower water usage.

    SciTech Connect (OSTI)

    Sanchez, Andres L.; Everett, Randy L.; Jensen, Richard Pearson; Cappelle, Malynda A.; Altman, Susan Jeanne

    2010-09-01

    Nanofiltration (NF) can effectively treat cooling-tower water to reduce water consumption and maximize water usage efficiency of thermoelectric power plants. A pilot is being run to verify theoretical calculations. A side stream of water from a 900 gpm cooling tower is being treated by NF with the permeate returning to the cooling tower and the concentrate being discharged. The membrane efficiency is as high as over 50%. Salt rejection ranges from 77-97% with higher rejection for divalent ions. The pilot has demonstrated a reduction of makeup water of almost 20% and a reduction of discharge of over 50%.

  14. http://www.ornl.gov/Procurement.PDF

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    8/93 1. All Grade 5 and Grade 8 fasteners of foreign origin which do not bear any manufacturer's headmarks: Grade 5 Grade 8 2. Grade 5 fasteners with the following manufacturers' headmarks: J Jinn Her (TW) KS Kosaka Kogyo (JP) J KS 3. Grade 8 fasteners with the following manufacturers' headmarks: A Asahi Mfg (JP) KS Kosaka Kogyo (JP) A KS NF RT NF Nippon Fasteners (JP) RT Takai Ltd (JP) H Hinomoto Metal (JP) FM Fastener Co (of JP) H FM J M MS KY M Minamida Sieybo (JP) KY Kyoei (JP) MS Minato

  15. Photon energy-modulated radiotherapy: Monte Carlo simulation and treatment planning study

    SciTech Connect (OSTI)

    Park, Jong Min; Kim, Jung-in; Heon Choi, Chang; Chie, Eui Kyu; Kim, Il Han; Ye, Sung-Joon

    2012-03-15

    Purpose: To demonstrate the feasibility of photon energy-modulated radiotherapy during beam-on time. Methods: A cylindrical device made of aluminum was conceptually proposed as an energy modulator. The frame of the device was connected with 20 tubes through which mercury could be injected or drained to adjust the thickness of mercury along the beam axis. In Monte Carlo (MC) simulations, a flattening filter of 6 or 10 MV linac was replaced with the device. The thickness of mercury inside the device varied from 0 to 40 mm at the field sizes of 5 x 5 cm{sup 2} (FS5), 10 x 10 cm{sup 2} (FS10), and 20 x 20 cm{sup 2} (FS20). At least 5 billion histories were followed for each simulation to create phase space files at 100 cm source to surface distance (SSD). In-water beam data were acquired by additional MC simulations using the above phase space files. A treatment planning system (TPS) was commissioned to generate a virtual machine using the MC-generated beam data. Intensity modulated radiation therapy (IMRT) plans for six clinical cases were generated using conventional 6 MV, 6 MV flattening filter free, and energy-modulated photon beams of the virtual machine. Results: As increasing the thickness of mercury, Percentage depth doses (PDD) of modulated 6 and 10 MV after the depth of dose maximum were continuously increased. The amount of PDD increase at the depth of 10 and 20 cm for modulated 6 MV was 4.8% and 5.2% at FS5, 3.9% and 5.0% at FS10 and 3.2%-4.9% at FS20 as increasing the thickness of mercury from 0 to 20 mm. The same for modulated 10 MV was 4.5% and 5.0% at FS5, 3.8% and 4.7% at FS10 and 4.1% and 4.8% at FS20 as increasing the thickness of mercury from 0 to 25 mm. The outputs of modulated 6 MV with 20 mm mercury and of modulated 10 MV with 25 mm mercury were reduced into 30%, and 56% of conventional linac, respectively. The energy-modulated IMRT plans had less integral doses than 6 MV IMRT or 6 MV flattening filter free plans for tumors located in the

  16. Predicting Pneumonitis Risk: A Dosimetric Alternative to Mean Lung Dose

    SciTech Connect (OSTI)

    Tucker, Susan L.; Mohan, Radhe; Liengsawangwong, Raweewan; Martel, Mary K.; Liao Zhongxing

    2013-02-01

    Purpose: To determine whether the association between mean lung dose (MLD) and risk of severe (grade {>=}3) radiation pneumonitis (RP) depends on the dose distribution pattern to normal lung among patients receiving 3-dimensional conformal radiation therapy for non-small-cell lung cancer. Methods and Materials: Three cohorts treated with different beam arrangements were identified. One cohort (2-field boost [2FB]) received 2 parallel-opposed (anteroposterior-posteroanterior) fields per fraction initially, followed by a sequential boost delivered using 2 oblique beams. The other 2 cohorts received 3 or 4 straight fields (3FS and 4FS, respectively), ie, all fields were irradiated every day. The incidence of severe RP was plotted against MLD in each cohort, and data were analyzed using the Lyman-Kutcher-Burman (LKB) model. Results: The incidence of grade {>=}3 RP rose more steeply as a function of MLD in the 2FB cohort (N=120) than in the 4FS cohort (N=138), with an intermediate slope for the 3FS group (N=99). The estimated volume parameter from the LKB model was n=0.41 (95% confidence interval, 0.15-1.0) and led to a significant improvement in fit (P=.05) compared to a fit with volume parameter fixed at n=1 (the MLD model). Unlike the MLD model, the LKB model with n=0.41 provided a consistent description of the risk of severe RP in all three cohorts (2FB, 3FS, 4FS) simultaneously. Conclusions: When predicting risk of grade {>=}3 RP, the mean lung dose does not adequately take into account the effects of high doses. Instead, the effective dose, computed from the LKB model using volume parameter n=0.41, may provide a better dosimetric parameter for predicting RP risk. If confirmed, these findings support the conclusion that for the same MLD, high doses to small lung volumes ('a lot to a little') are worse than low doses to large volumes ('a little to a lot').

  17. ASN Aircraft accident Beechcraft 1900C N27RA Tonopah-Test Range...

    National Nuclear Security Administration (NNSA)

    Accident description languages: Share 0 Statd,LB:5E)(WEWkNF75WLEW)w(Ni7wkE.(wnNa75WLEW)w(... According to the Air Force Materiel Command Accident Investigation Board report, the pilot ...

  18. Double-stranded RNA transcribed from vector-based oligodeoxynucleotide acts as transcription factor decoy

    SciTech Connect (OSTI)

    Xiao, Xiao; Gang, Yi; Wang, Honghong; Wang, Jiayin; Zhao, Lina; Xu, Li; Liu, Zhiguo

    2015-02-06

    Highlights: • A shRNA vector based transcription factor decoy, VB-ODN, was designed. • VB-ODN for NF-κB inhibited cell viability in HEK293 cells. • VB-ODN inhibited expression of downstream genes of target transcription factors. • VB-ODN may enhance nuclear entry ratio for its feasibility of virus production. - Abstract: In this study, we designed a short hairpin RNA vector-based oligodeoxynucleotide (VB-ODN) carrying transcription factor (TF) consensus sequence which could function as a decoy to block TF activity. Specifically, VB-ODN for Nuclear factor-κB (NF-κB) could inhibit cell viability and decrease downstream gene expression in HEK293 cells without affecting expression of NF-κB itself. The specific binding between VB-ODN produced double-stranded RNA and NF-κB was evidenced by electrophoretic mobility shift assay. Moreover, similar VB-ODNs designed for three other TFs also inhibit their downstream gene expression but not that of themselves. Our study provides a new design of decoy for blocking TF activity.

  19. Nor AMENDMENT OF SOUCITAnONlM001~CA.nQN ...

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    ... Ind lI"bcontu" tar .... ublect UI hil wige d4:te.rminltlon ahall Hn t ... .-b.t'nfI of * bonl ide ctlllac'Jve barql1nl:19 19:1'ell'ent providinq (::It I d1HerOnt Ilr>eUI"'. ...

  20. Radiation-induced gene responses

    SciTech Connect (OSTI)

    Woloschak, G.E.; Paunesku, T.; Shearin-Jones, P.; Oryhon, J.

    1996-12-31

    In the process of identifying genes that are differentially regulated in cells exposed to ultraviolet radiation (UV), we identified a transcript that was repressed following the exposure of cells to a combination of UV and salicylate, a known inhibitor of NF-kappaB. Sequencing this band determined that it has identify to lactate dehydrogenase, and Northern blots confirmed the initial expression pattern. Analysis of the sequence of the LDH 5` region established the presence of NF-kappaB, Sp1, and two Ap-2 elements; two partial AP- 1; one partial RE, and two halves of E-UV elements were also found. Electromobility shift assays were then performed for the AP-1, NF- kappaB, and E-UV elements. These experiments revealed that binding to NF-kappaB was induced by UV but repressed with salicylic acid; UV did not affect AP-1 binding, but salicylic acid inhibited it alone or following UV exposure; and E-UV binding was repressed by UV, and salicylic acid had little effect. Since the binding of no single element correlated with the expression pattern of LDH, it is likely that multiple elements govern UV/salicylate-mediated expression.

  1. Ni(OH){sub 2} nanoflakes electrodeposited on Ni foam-supported vertically oriented graphene nanosheets for application in asymmetric supercapacitors

    SciTech Connect (OSTI)

    Wang, Xin; Liu, Jiyue; Wang, Yayu; Zhao, Cuimei; Zheng, Weitao

    2014-04-01

    Highlights: Ni(OH){sub 2}/vertically oriented graphene nanosheets (V-GNs) was prepared. Ni(OH){sub 2}/V-GNs had enhanced specific capacitance, cycling reversibility and stability. Performance of Ni(OH){sub 2}/GNs/NF-AC asymmetric supercapacitor was studied. - Abstract: Binderless Ni(OH){sub 2} nanoflakes grown on Ni foam (NF)-supported vertically oriented graphene nanosheets (V-GNs) has been fabricated as a positive electrode material for asymmetric supercapacitor (ASC), coupled with activated carbon (AC) as a counter electrode material. The introduction of V-GNs leads to dense growth of nanocrystalline ?-Ni(OH){sub 2} that is confirmed by X-ray diffraction, transmission electron microscopic and scanning electron microscopic analyses. The electrochemical performances of the Ni(OH){sub 2}/GNs/NF electrode are characterized by cyclic voltammetry and chargedischarge tests, which exhibit high specific capacitance of 2215 F g{sup ?1} at a scan current density of 2.3 A g{sup ?1}, enhanced cycling stability and high rate capability. The Ni(OH){sub 2}/GNs/NF-AC-based ASC can achieve a cell voltage of 1.4 V and a specific energy density of 11.11 Wh kg{sup ?1} at 0.5 mA cm{sup ?2} with a nearly 100% coulombic efficiency at room temperature.

  2. Microsoft PowerPoint - 2009_DEMO_Career_Paths_DCB_Salaries.ppt...

    National Nuclear Security Administration (NNSA)

    Band 02 60,989 to 79,280 Band 03 73,100 to 95,026 Band 04 86,927 to 113,007 Future Leader (NF) Band 01 33,269 - 59,333 Band 02 50,408 - 79,280 Band 03 73,100 - 113,007...

  3. Microsoft PowerPoint - 2009_DEMO_Career_Paths_RUS_Salaries.ppt...

    National Nuclear Security Administration (NNSA)

    Band 02 56,411 to 73,329 Band 03 67,613 to 87,893 Band 04 80,402 to 104,525 Future Leader (NF) Band 01 30,772 - 54,879 Band 02 46,625 - 73,329 Band 03 67,613 - 104,52...

  4. Microsoft PowerPoint - 2009_DEMO_Career_Paths_OAK_Salaries.ppt...

    National Nuclear Security Administration (NNSA)

    Band 02 66,562 to 86,525 Band 03 79,781 to 103,710 Band 04 94,871 to 123,335 Future Leader (NF) Band 01 36,309 - 64,755 Band 02 55,015 - 86,525 Band 03 79,781 - 123,33...

  5. SIRT1 inactivation induces inflammation through the dysregulation of autophagy in human THP-1 cells

    SciTech Connect (OSTI)

    Takeda-Watanabe, Ai; Kitada, Munehiro; Kanasaki, Keizo; Koya, Daisuke

    2012-10-12

    Highlights: Black-Right-Pointing-Pointer SIRT1 inactivation decreases autophagy in THP-1 cell. Black-Right-Pointing-Pointer Inhibition of autophagy induces inflammation. Black-Right-Pointing-Pointer SIRT1 inactivation induces inflammation through NF-{kappa}B activation. Black-Right-Pointing-Pointer The p62/Sqstm1 accumulation by impairment of autophagy is related to NF-{kappa}B activation. Black-Right-Pointing-Pointer SIRT1 inactivation is involved in the activation of mTOR and decreased AMPK activation. -- Abstract: Inflammation plays a crucial role in atherosclerosis. Monocytes/macrophages are some of the cells involved in the inflammatory process in atherogenesis. Autophagy exerts a protective effect against cellular stresses like inflammation, and it is regulated by nutrient-sensing pathways. The nutrient-sensing pathway includes SIRT1, a NAD{sup +}-dependent histone deacetylase, which is implicated in the regulation of a variety of cellular processes including inflammation and autophagy. The mechanism through which the dysfunction of SIRT1 contributes to the regulation of inflammation in relation to autophagy in monocytes/macrophages is unclear. In the present study, we demonstrate that treatment with 2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide (Sirtinol), a chemical inhibitor of SIRT1, induces the overexpression of inflammation-related genes such as tumor necrosis factor (TNF)-{alpha} and interleukin (IL)-6 through nuclear factor (NF)-{kappa}B signaling activation, which is associated with autophagy dysfunction, as shown through p62/Sqstm1 accumulation and decreased expression of light chain (LC) 3 II in THP-1 cells. The autophagy inhibitor, 3-methyladenine, also induces inflammation-related NF-{kappa}B activation. In p62/Sqstm1 knockdown cells, Sirtinol-induced inflammation through NF-{kappa}B activation is blocked. In addition, inhibition of SIRT1 is involved in the activation of the mammalian target of rapamycin (mTOR) pathway and

  6. Daily treatment with {alpha}-naphthoflavone enhances follicular growth and ovulation rate in the rat

    SciTech Connect (OSTI)

    Barreiro, Karina A.; Di Yorio, Maria P.; Artillo-Guida, Romina D.; Paz, Dante A.; Faletti, Alicia G.

    2011-04-01

    The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and the first protein involved in a variety of physiological and toxicological processes, including those of xenobiotic metabolizing enzymes. AhR has been found in the ovary of many species and seems to mediate the ovarian toxicity of many environmental contaminants, which are AhR ligands. However, the role of AhR in the ovarian function is unknown. Therefore, the aim of this work was to study the action of {alpha}-naphthoflavone ({alpha}NF), known to be an AhR antagonist, on both follicular growth and ovulation. Immature Sprague-Dawley rats were daily injected intraperitoneally with {alpha}NF (0.1-80 mg/kg) or vehicle for 12 days, and primed with gonadotrophins (eCG/hCG) to induce follicular growth and ovulation. Ovaries were obtained 20 h after hCG administration. By means of immunohistochemistry, we found that the numbers of primordial, primary and antral follicles were increased in rats treated with 80 mg/kg {alpha}NF and that there were no differences with other doses. Likewise, the ovarian weight and the ovulation rate, measured by both number of oocytes within oviducts and corpora lutea in ovarian sections, were increased when the rats received either 1 or 10 mg/kg daily. Although further studies are necessary to know the mechanism of action of {alpha}NF, it is possible that the different ovarian processes can be differentially responsive to the presence of different levels of {alpha}NF, and that the same or different endogenous AhR ligands can be involved in these ovarian processes in a cell type-dependent manner.

  7. Arsenic augments the uptake of oxidized LDL by upregulating the expression of lectin-like oxidized LDL receptor in mouse aortic endothelial cells

    SciTech Connect (OSTI)

    Hossain, Ekhtear; Ota, Akinobu; Karnan, Sivasundaram; Damdindorj, Lkhagvasuren; Takahashi, Miyuki; Konishi, Yuko; Konishi, Hiroyuki; Hosokawa, Yoshitaka

    2013-12-15

    Although chronic arsenic exposure is a well-known risk factor for cardiovascular diseases, including atherosclerosis, the molecular mechanism underlying arsenic-induced atherosclerosis remains obscure. Therefore, this study aimed to elucidate this molecular mechanism. We examined changes in the mRNA level of the lectin-like oxidized LDL (oxLDL) receptor (LOX-1) in a mouse aortic endothelial cell line, END-D, after sodium arsenite (SA) treatment. SA treatment significantly upregulated LOX-1 mRNA expression; this finding was also verified at the protein expression level. Flow cytometry and fluorescence microscopy analyses showed that the cellular uptake of fluorescence (Dil)-labeled oxLDL was significantly augmented with SA treatment. In addition, an anti-LOX-1 antibody completely abrogated the augmented uptake of Dil-oxLDL. We observed that SA increased the levels of the phosphorylated forms of nuclear factor of kappa light polypeptide gene enhancer in B cells (NF-κB)/p65. SA-induced upregulation of LOX-1 protein expression was clearly prevented by treatment with an antioxidant, N-acetylcysteine (NAC), or an NF-κB inhibitor, caffeic acid phenethylester (CAPE). Furthermore, SA-augmented uptake of Dil-oxLDL was also prevented by treatment with NAC or CAPE. Taken together, our results indicate that arsenic upregulates LOX-1 expression through the reactive oxygen species-mediated NF-κB signaling pathway, followed by augmented cellular oxLDL uptake, thus highlighting a critical role of the aberrant LOX-1 signaling pathway in the pathogenesis of arsenic-induced atherosclerosis. - Highlights: • Sodium arsenite (SA) increases LOX-1 expression in mouse aortic endothelial cells. • SA enhances cellular uptake of oxidized LDL in dose-dependent manner. • SA-induced ROS generation enhances phosphorylation of NF-κB. • SA upregulates LOX-1 expression through ROS-activated NF-κB signaling pathway.

  8. High glucose induces inflammatory cytokine through protein kinase C-induced toll-like receptor 2 pathway in gingival fibroblasts

    SciTech Connect (OSTI)

    Jiang, Shao-Yun; Wei, Cong-Cong; Shang, Ting-Ting; Lian, Qi; Wu, Chen-Xuan; Deng, Jia-Yin

    2012-10-26

    Highlights: Black-Right-Pointing-Pointer High glucose significantly induced TLR2 expression in gingival fibroblasts. Black-Right-Pointing-Pointer High glucose increased NF-{kappa}B p65 nuclear activity, IL-1{beta} and TNF-{alpha} levels. Black-Right-Pointing-Pointer PKC-{alpha}/{delta}-TLR2 pathway is involved in periodontal inflammation under high glucose. -- Abstract: Toll-like receptors (TLRs) play a key role in innate immune response and inflammation, especially in periodontitis. Meanwhile, hyperglycemia can induce inflammation in diabetes complications. However, the activity of TLRs in periodontitis complicated with hyperglycemia is still unclear. In the present study, high glucose (25 mmol/l) significantly induced TLR2 expression in gingival fibroblasts (p < 0.05). Also, high glucose increased nuclear factor kappa B (NF-{kappa}B) p65 nuclear activity, tumor necrosis factor-{alpha} (TNF-{alpha}) and interleukin-l{beta} (IL-1{beta}) levels. Protein kinase C (PKC)-{alpha} and {delta} knockdown with siRNA significantly decreased TLR2 and NF-{kappa}B p65 expression (p < 0.05), whereas inhibition of PKC-{beta} had no effect on TLR2 and NF-{kappa}B p65 under high glucose (p < 0.05). Additional studies revealed that TLR2 knockdown significantly abrogated high-glucose-induced NF-{kappa}B expression and inflammatory cytokine secretion. Collectively, these data suggest that high glucose stimulates TNF-{alpha} and IL-1{beta} secretion via inducing TLR2 through PKC-{alpha} and PKC-{delta} in human gingival fibroblasts.

  9. Environmental Restoration Program pollution prevention checklist guide for the feasibility study project phase

    SciTech Connect (OSTI)

    Not Available

    1993-09-01

    Feasibility studies (FS) determine what remedial alternatives are presented to regulators for site cleanup. A key consideration in this process is the waste to be generated. Minimizing the volume and toxicity of this waste will ultimately contribute to the selection of the best remedial option. The purpose of this checklist guide is to assist the user in incorporating pollution prevention/waste minimization (PP/WM) in all FS phase projects of the Environmental Restoration (ER) Program. This guide will help users document PP/WM activities for technology transfer and reporting requirements. Automated computer screens will be created from the checklist data to assist users with implementing and evaluating waste reduction. Users can then establish numerical performance measures to measure progress in planning, training, self-assessments, field implementation, documentation, and technology transfer. Cost savings result as users train and assess themselves and perform preliminary waste assessments.

  10. Search for the decay Bs0 ? ?? and a measurement of the branching fraction for Bs0 ? ??

    SciTech Connect (OSTI)

    Dutta, Deepanwita; Bhuyan, Bipul; Abdesselam, A.; Adachi, I.; Aihara, H.; Al Said, S.; Arinstein, K.; Asner, David M.; Aulchenko, V.; Aushev, T.; Ayad, R.; Aziz, T.; Bahinipati, S.; Bakich, A. M.; Bansal, Vikas; Bhardwaj, V.; Bobrov, A.; Bonvicini, Giovanni; Bracko, Marko; Browder, Thomas E.; Cervenkov, D.; Chen, A.; Cheon, B. G.; Chilikin, K.; Chistov, R.; Cho, K.; Chobanova, V.; Choi, Y.; Cinabro, David A.; Dalseno, J.; Dolezal, Z.; Drasal, Z.; Drutskoy, A.; Dutta, K.; Eidelman, S.; Farhat, H.; Fast, James E.; Frost, O.; Gaur, Vipin; Ganguly, Sudeshna; Garmash, Alexey; Getzkow, D.; Goh, Y. M.; Golob, B.; Hayashii, H.; He, X. H.; Hou, W. S.; Iijima, T.; Ishikawa, A.; Iwasaki, Y.; Jaegle, Igal; Joffe, D.; Kang, K. H.; Kato, E.; Kiesling, C.; Kim, D. Y.; Kim, J. B.; Kim, J. H.; Kim, K. T.; Kim, M. J.; Kim, S. H.; Kim, Y. J.; Kinoshita, Kay; Ko, Byeong Rok; Kodys, P.; Korpar, S.; Krizan, P.; Krokovny, Pavel; Kuhr, Thomas; Kuzmin, A.; Kwon, Y. J.; Lange, J. S.; Lee, I. S.; Lewis, P.; Li, Y.; Li Gioi, L.; Libby, J.; Liventsev, Dmitri; Matvienko, D.; Miyata, H.; Mizuk, R.; Mohanty, G. B.; Moll, A.; Mori, T.; Mussa, R.; Nakano, E.; Nakao, M.; Nanut, T.; Nayak, Minakshi; Nisar, N. K.; Nishida, S.; Ogawa, S.; Okuno, S.; Pakhlov, P.; Pakhlova, Galina; Pedlar, Todd K.; Pestotnik, Rok; Petric, Marko; Piilonen, Leo E.; Ribezl, Eva; Ritter, M.; Rostomyan, A.; Sakai, Y.; Sandilya, Saurabh; Santelj, Luka; Sanuki, T.; Sato, Y.; Savinov, Vladimir; Schneider, O.; Schnell, G.; Schwanda, C.; Schwartz, A. J.; Semmler, D.; Shebalin, V.; Shibata, T. A.; Shiu, Jing-Ge; Shwartz, B.; Sibidanov, A.; Simon, F.; Sohn, Y. S.; Sokolov, A.; Solovieva, E.; Staric, M.; Sumihama, M.; Sumiyoshi, T.; Teramoto, Y.; Trabelsi, K.; Uchida, M.; Unno, Yuji; Uno, S.; Usov, Y.; Van Hulse, C.; Vanhoefer, P.; Varner, G.; Vinokurova, A.; Vossen, Anslem G.; Wagner, M. N.; Wang, C. H.; Wang, P.; Watanabe, Y.; Wehle, S.; Williams, K. M.; Won, E.; Yamamoto, H.; Yamaoka, J.; Yashchenko, S.; Yusa, Y.; Zhang, Z. P.; Zhilich, V.; Zupanc, A.

    2015-01-01

    We search for the decay B0s??? and measure the branching fraction for B0s??? using 121.4~fb-1 of data collected at the ?(5S) resonance with the Belle detector at the KEKB asymmetric-energy e+e- collider. The B0s??? branching fraction is measured to be (3.60.5(stat.)0.3(syst.)0.6(fs))10-5, where fs is the fraction of Bs(*)Bs(*) in bb events. Our result is in good agreement with the theoretical predictions as well as with a recent measurement from LHCb. We observe no statistically significant signal for the decay B0s??? and set a 90% confidence-level upper limit on its branching fraction at 3.110-6. This constitutes a significant improvement over the previous result.

  11. Generation of an isolated sub-40-as pulse using two-color laser pulses: Combined chirp effects

    SciTech Connect (OSTI)

    Feng, Liqiang [State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023 (China); Chu, Tianshu [State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023 (China); Institute for Computational Sciences and Engineering, Laboratory of New Fiber Materials and Modern Textile, the Growing Base for State Key Laboratory, Qingdao University, Qingdao, 266071 (China)

    2011-11-15

    In this paper, we theoretically discuss the combined chirp effects on the isolated attosecond generation when a model Ar is exposed to an intense 5-fs, 800-nm fundamental chirped pulse combined with a weak 10-fs, 1200-nm controlling chirped pulse. It shows that for the case of the chirp parameters {beta}{sub 1} = 6.1 (corresponding to the 800-nm field) and {beta}{sub 2} = 4.0 (corresponding to the 1200-nm field), both the harmonic cutoff energy and the supercontinuum can be remarkably extended resulting in a 663-eV bandwidth. Moreover, due to the introduction of the chirps, the short quantum path is selected to contribute to the harmonic spectrum. Finally, by superposing a properly selected harmonic spectrum in the supercontinuum region, an isolated pulse as short as 31 as (5 as) is generated without (with) phase compensation.

  12. Acoustically determined linear piezoelectric response of lithium niobate up to 1100 V

    SciTech Connect (OSTI)

    Patel, N.; Branch, D. W.; Cular, S.; Schamiloglu, E.

    2014-04-21

    We present a method to measure high voltages using the piezoelectric crystal lithium niobate without using voltage dividers. A 36° Y-X cut lithium niobate crystal was coupled to two acoustic transducers, where direct current voltages were applied from 128–1100 V. The time-of-flight through the crystal was determined to be linearly dependent on the applied voltage. A model was developed to predict the time-delay in response to the applied voltage. The results show a sensitivity of 17 fs/V with a measurement error of 1 fs/V was achievable using this method. The sensitivity of this method can be increased by measuring the acoustic wave after multiple passes through the crystal. This method has many advantages over traditional techniques such as: favorable scalability for larger voltages, ease of use, cost effectiveness, and compactness.

  13. Friction surfaced Stellite6 coatings

    SciTech Connect (OSTI)

    Rao, K. Prasad; Damodaram, R.; Rafi, H. Khalid; Ram, G.D. Janaki; Reddy, G. Madhusudhan; Nagalakshmi, R.

    2012-08-15

    Solid state Stellite6 coatings were deposited on steel substrate by friction surfacing and compared with Stellite6 cast rod and coatings deposited by gas tungsten arc and plasma transferred arc welding processes. Friction surfaced coatings exhibited finer and uniformly distributed carbides and were characterized by the absence of solidification structure and compositional homogeneity compared to cast rod, gas tungsten arc and plasma transferred coatings. Friction surfaced coating showed relatively higher hardness. X-ray diffraction of samples showed only face centered cubic Co peaks while cold worked coating showed hexagonally close packed Co also. - Highlights: Black-Right-Pointing-Pointer Stellite6 used as coating material for friction surfacing. Black-Right-Pointing-Pointer Friction surfaced (FS) coatings compared with casting, GTA and PTA processes. Black-Right-Pointing-Pointer Finer and uniformly distributed carbides in friction surfaced coatings. Black-Right-Pointing-Pointer Absence of melting results compositional homogeneity in FS Stellite6 coatings.

  14. Thermal decomposition of electronic wastes: Mobile phone case and other parts

    SciTech Connect (OSTI)

    Molto, Julia; Egea, Silvia; Conesa, Juan Antonio; Font, Rafael

    2011-12-15

    Highlights: > Pyrolysis and combustion of different parts of mobile phones produce important quantities of CO and CO{sub 2}. > Naphthalene is the most abundant PAH obtained in the thermal treatment of mobile phones. > Higher combustion temperature increases the chlorinated species evolved. - Abstract: Pyrolysis and combustion runs at 850 {sup o}C in a horizontal laboratory furnace were carried out on different parts of a mobile phone (printed circuit board, mobile case and a mixture of both materials). The analyses of the carbon oxides, light hydrocarbons, polycyclic aromatic hydrocarbons (PAHs), polychlorodibenzo-p-dioxin, polychlorodibenzofurans (PCDD/Fs), and dioxin-like PCBs are shown. Regarding semivolatile compounds, phenol, styrene, and its derivatives had the highest yields. In nearly all the runs the same PAHs were identified, naphthalene being the most common component obtained. Combustion of the printed circuit board produced the highest emission factor of PCDD/Fs, possibly due to the high copper content.

  15. Formation of laser-induced periodic surface structures on fused silica upon two-color double-pulse irradiation

    SciTech Connect (OSTI)

    Höhm, S.; Herzlieb, M.; Rosenfeld, A.; Krüger, J.; Bonse, J.

    2013-12-16

    The formation of laser-induced periodic surface structures (LIPSS) upon irradiation of fused silica with multiple irradiation sequences consisting of laser pulse pairs (50 fs single-pulse duration) of two different wavelengths (400 and 800 nm) is studied experimentally. Parallel polarized double-pulse sequences with a variable delay Δt between −10 and +10 ps and between the individual fs-laser pulses were used to investigate the LIPSS periods versus Δt. These two-color experiments reveal the importance of the ultrafast energy deposition to the silica surface by the first laser pulse for LIPSS formation. The second laser pulse subsequently reinforces the previously seeded spatial LIPSS frequencies.

  16. Table

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    38 from (2012KE01): Energy levels of 11 C a E x in 11 C J π ; T T 1 2 or Γ cm Decay Reactions (MeV ± keV) 0 3 2 - ; 1 2 T 1 2 = 20.364 ± 0.014 min β + 1, 2, 6, 7, 10, 16, 17, 18, 19, 21, 22, 23, 24, 25, 26, 27, 28, 30, 31, 32, 33, 34, 35, 37, 38, 39, 40, 41, 43, 44 2.0000 ± 0.4 1 2 - T 1 2 = 7.1 ± 0.5 fs γ 2, 3, 6, 7, 10, 16, 17, 18, 19, 21, 22, 26, 28, 30, 31, 32, 33, 38, 39, 44 4.3188 ± 1.2 5 2 - < 8.3 fs γ 2, 3, 6, 7, 10, 16, 17, 19, 21, 22, 26, 28, 30, 31, 34, 38, 39, 44 4.8042

  17. Repetition frequency scaling of an all-polarization maintaining erbium-doped mode-locked fiber laser based on carbon nanotubes saturable absorber

    SciTech Connect (OSTI)

    Sotor, J. Sobon, G.; Abramski, K. M.; Jagiello, J.; Lipinska, L.

    2015-04-07

    We demonstrate an all-polarization maintaining (PM), mode-locked erbium (Er)-doped fiber laser based on a carbon nanotubes (CNT) saturable absorber (SA). The laser resonator was maximally simplified by using only one passive hybrid component and a pair of fiber connectors with deposited CNTs. The repetition frequency (F{sub rep}) of such a cost-effective and self-starting mode-locked laser was scaled from 54.3 MHz to 358.6 MHz. The highest F{sub rep} was obtained when the total cavity length was shortened to 57 cm. The laser allows ultrashort pulse generation with the duration ranging from 240 fs to 550 fs. Because the laser components were based on PM fibers the laser was immune to the external perturbations and generated laniary polarized light with the degree of polarization (DOP) of 98.7%.

  18. PULSAR: A High-Repetition-Rate, High-Power, CE Phase-Locked Laser for the J.R. Macdonald Laboratory at Kansas State University

    SciTech Connect (OSTI)

    Ben-Itzhak, Itzik; Carnes, Kevin D.; Cocke, C. Lew; Fehrenbach, Charles W.; Kumarappan, Vinod; Rudenko, Artem; Trallero, Carlos

    2014-05-09

    This instrumentation grant funded the development and installation of a state-of-the-art laser system to be used for the DOE funded research at the J.R. Macdonald Laboratory at Kansas State University. Specifically, we purchased a laser based on the KMLABs Red-Dragon design, which has a high repetition rate of 10-20 kHz crucial for multi-parameter coincidence measurements conducted in our lab. This laser system is carrier-envelope phase (CEP) locked and provides pulses as short as 21 fs directly from the amplifier (see details below). In addition, we have developed a pulse compression setup that provides sub 5 fs pulses and a CEP tagging capability that allows for long measurements of CEP dependent processes.

  19. Formation of Gapless Fermi Arcs and Fingerprints of Order in the Pseudogap State of Cuprate Superconductors

    SciTech Connect (OSTI)

    Kondo, Takeshi; Palczewski, Ari; Hamaya, Yoichiro; Takeuchi, Tsunehiro; Wen, J. S.; Xu, Z. J.; Gu, Genda; Kaminski, Adam

    2013-10-08

    We use angle-resolved photoemission spectroscopy and a new quantitative approach based on the partial density of states to study properties of seemingly disconnected portions of the Fermi surface (FS) that are present in the pseudogap state of cuprates called Fermi arcs. We find that the normal state FS collapses very abruptly into Fermi arcs at the pseudogap temperature (T*). Surprisingly, the length of the Fermi arcs remains constant over an extended temperature range between (T*) and Tpair, consistent with the presence of an ordered state below T*. These arcs collapse again at the temperature below which pair formation occurs (Tpair) either to a point or a very short arc, whose length is limited by our experimental resolution. The tips of the arcs span between points defining a set of wave vectors in momentum space, which are the fingerprints of the ordered state that causes the pseudogap.

  20. Formation of Gapless Fermi Arcs and Fingerprints of Order in the Pseudogap State of Cuprate Superconductors

    SciTech Connect (OSTI)

    Kondo, Takeshi; Palczewski, Ari D.; Hamaya, Yoichiro; Takeuchi, Tsunehiro; Wen, J. S.; Gu, Genda; Kaminski, Adam

    2013-10-11

    We use angle-resolved photoemission spectroscopy and a new quantitative approach based on the partial density of states to study properties of seemingly disconnected portions of the Fermi surface (FS) that are present in the pseudogap state of cuprates called Fermi arcs. We find that the normal state FS collapses very abruptly into Fermi arcs at the pseudogap temperature (T?). Surprisingly, the length of the Fermi arcs remains constant over an extended temperature range between T? and Tpair, consistent with the presence of an ordered state below T?. These arcs collapse again at the temperature below which pair formation occurs (Tpair) either to a point or a very short arc, whose length is limited by our experimental resolution. The tips of the arcs span between points defining a set of wave vectors in momentum space, which are the fingerprints of the ordered state that causes the pseudogap.