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Sample records for midwest canada mi

  1. Port Huron, MI Liquefied Natural Gas Exports to Canada (Million...

    Energy Information Administration (EIA) (indexed site)

    Huron, MI Liquefied Natural Gas Exports to Canada (Million Cubic Feet) Port Huron, MI Liquefied Natural Gas Exports to Canada (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul ...

  2. Midwest

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Midwest Climate C hange a nd t he U .S. E nergy S ector: Regional v ulnerabilities a nd r esilience s olutions Summary i n B rief The M idwest i s h ome t o e xpansive a gricultural l ands, f orests i n the n orth, t he G reat L akes, s ubstantial i ndustrial a ctivity, a nd major u rban c enters. T he r egion h as a n e nergy---intensive economy, a nd i ts e lectricity m ix i s h eavily d ependent o n thermoelectric p lants, w ith c oal--- a nd n atural g as---fired p ower plants a ccounting f

  3. Port Huron, MI Natural Gas Pipeline Imports From Canada (Million...

    Energy Information Administration (EIA) (indexed site)

    Million Cubic Feet) Port Huron, MI Natural Gas Pipeline Imports From Canada (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2016 262 - No Data Reported; ...

  4. Midwest Renewable Energy Corporation Partners LLC | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    Sector: Wind energy Product: Iberdrola subsidiary that develops wind farms in Midwest USA and Canada. References: Midwest Renewable Energy Corporation Partners LLC1 This...

  5. ,"Detroit, MI Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Detroit, MI Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  6. ,"Marysville, MI Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Marysville, MI Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  7. ,"St. Clair, MI Natural Gas Pipeline Exports to Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Exports to Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","St. Clair, MI Natural Gas Pipeline Exports to Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  8. ,"St. Clair, MI Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","St. Clair, MI Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  9. Marysville, MI Natural Gas Pipeline Imports From Canada (Million Cubic

    Energy Information Administration (EIA) (indexed site)

    Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 10 1,827 135 2000's NA NA 74 0 303 0 24 876 2,252 5,651 2010's 5,694 9,946 8,099 2,337 4,650 1,961 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Natural Gas Pipeline Imports by Point of Entry Marysville, MI Natural Gas Imports by Pipeli

  10. Marysville, MI Natural Gas Pipeline Imports From Canada (Dollars per

    Energy Information Administration (EIA) (indexed site)

    Thousand Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 3.48 2.17 2.06 2000's NA NA 3.95 -- 7.80 -- 7.07 7.59 8.59 3.80 2010's 4.44 4.42 2.99 4.15 6.86 2.73 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Price of Natural Gas Pipeline Imports by Point of Entry Marysville, MI Natural Gas

  11. Port Huron, MI Natural Gas Pipeline Imports From Canada (Dollars per

    Energy Information Administration (EIA) (indexed site)

    Thousand Cubic Feet) Dollars per Thousand Cubic Feet) Port Huron, MI Natural Gas Pipeline Imports From Canada (Dollars per Thousand Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2016 2.07 2.06 2.21 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Price of

  12. ,"Sault St Marie, MI Natural Gas Pipeline Exports to Canada (Million Cubic Feet)"

    Energy Information Administration (EIA) (indexed site)

    Sault St Marie, MI Natural Gas Pipeline Exports to Canada (Million Cubic Feet)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Sault St Marie, MI Natural Gas Pipeline Exports to Canada (Million Cubic Feet)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release

  13. NASEO Midwest Regional Meeting

    Energy.gov [DOE]

    The National Association of State Energy Officials (NASEO) is hosting its Midwest Regional Meeting in Des Moines, Iowa.

  14. St. Clair, MI Natural Gas Pipeline Imports From Canada (Million Cubic Feet)

    Energy Information Administration (EIA) (indexed site)

    Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 14,132 11,855 34,592 33,388 2000's 17,198 21,747 28,441 5,202 22,853 18,281 10,410 9,633 9,104 6,544 2010's 5,591 5,228 3,531 6,019 16,409 9,024 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Natural Gas Pipeline Imports by Point of Entry St. Clair, MI Natural

  15. Hawkeye Renewables formerly Midwest Renewables | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    (formerly Midwest Renewables) Place: Iowa Falls, Iowa Zip: 50126 Product: Midwest bioethanol producer References: Hawkeye Renewables (formerly Midwest Renewables)1 This...

  16. Midwest Industrial Energy Efficiency Handbook

    SciTech Connect

    2010-06-25

    This Industrial Technologies Program handbook connects industry with the various energy efficiency resources available in the midwest.

  17. 2016 Midwest Energy Solutions Conference

    Energy.gov [DOE]

    The Midwest Energy Efficiency Alliance invites all energy stakeholders to gather at the annual Midwest Energy Solutions Conference to raise awareness and reinforce the importance of energy efficiency in the Midwest. This annual conference is about celebrating accomplishments and inspirations in energy efficiency, as well as laying out the efficiency program and policy landscape for the coming year.

  18. MEEA Midwest Energy Solutions Conference

    Energy.gov [DOE]

    Midwest Energy Efficiency Alliance (MEEA) is hosting its annual conference at the Chicago Hilton and Towers in Chicago, IL, on Jan. 28-30, 2015.

  19. Midwest Energy Cooperative | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Phone Number: 800.492.5989 Website: www.teammidwest.com Twitter: @TeamMidwestCoop Facebook: https:www.facebook.compagesMidwest-Energy-Cooperative315135885402 Outage...

  20. EIA - Natural Gas Pipeline System - Midwest Region

    Energy Information Administration (EIA) (indexed site)

    Midwest Region About U.S. Natural Gas Pipelines - Transporting Natural Gas based on data through 20072008 with selected updates Natural Gas Pipelines in the Midwest Region ...

  1. Midwest Biodiesel Products | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Products Jump to: navigation, search Name: Midwest Biodiesel Products Place: Caseyville, Illinois Zip: 62232 Product: Midwest Biodiesel Products, Inc. is an Illinois based...

  2. Midwest Wind Finance LLC | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Jump to: navigation, search Name: Midwest Wind Finance LLC Place: Minnesota Sector: Wind energy Product: Wind project equity finance provider. References: Midwest Wind Finance...

  3. Midwest Renewable Energy Corporation | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Corporation Jump to: navigation, search Name: Midwest Renewable Energy Corporation Place: Joice, Iowa Zip: Iowa 50446 Sector: Renewable Energy, Wind energy Product: Midwest...

  4. Midwest Underground Technology | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Underground Technology Jump to: navigation, search Name Midwest Underground Technology Facility Midwest Underground Technology Sector Wind energy Facility Type Small Scale Wind...

  5. Midwest Independent Transmission System Operator | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    Midwest Independent Transmission System Operator Jump to: navigation, search Name: Midwest Independent Transmission System Operator Place: Carmel, IN References: SGIC1 This...

  6. 2016 Midwest Energy Solutions Conference

    Energy.gov [DOE]

    Once a year, MEEA invites all energy stakeholders to gather at our annual Midwest Energy Solutions Conference to raise awareness and reinforce the importance of energy efficiency in the Midwest. MES is about celebrating accomplishments in energy efficiency, as well as laying out the efficiency program and policy landscape for the coming year.

  7. Midwest Hydro Users Group Meeting

    Energy.gov [DOE]

    The Midwest Hydro Users Group will be holding their annual Fall meeting on November 12th and 13th in Wausau, Wisconsin.  An Owners-only meeting on the afternoon of the 12th followed by a full...

  8. ITC Midwest LLC | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    ITC Midwest LLC Jump to: navigation, search Name: ITC Midwest LLC Place: Michigan Phone Number: (877) 482-4829 or 319-297-6731 Website: www.itc-holdings.comitc-midwe Twitter:...

  9. Midwest Alliance of Sovereign Tribes Summer Meeting

    Office of Energy Efficiency and Renewable Energy (EERE)

    The Midwest Alliance of Sovereign Tribes (MAST) Summer Meeting is a two-day meeting featuring tribal leader roundtable discussions.

  10. Midwest Clean Energy Application Center

    SciTech Connect

    Cuttica, John; Haefke, Cliff

    2013-12-31

    The Midwest Clean Energy Application Center (CEAC) was one of eight regional centers that promoted and assisted in transforming the market for combined heat and power (CHP), waste heat to power (WHP), and district energy (DE) technologies and concepts throughout the United States between October 1, 2009 and December 31, 2013. The key services the CEACs provided included: Market Opportunity Analyses – Supporting analyses of CHP market opportunities in diverse markets including industrial, federal, institutional, and commercial sectors. Education and Outreach – Providing information on the energy and non-energy benefits and applications of CHP to state and local policy makers, regulators, energy end-users, trade associations and others. Information was shared on the Midwest CEAC website: www.midwestcleanergy.org. Technical Assistance – Providing technical assistance to end-users and stakeholders to help them consider CHP, waste heat to power, and/or district energy with CHP in their facility and to help them through the project development process from initial CHP screening to installation. The Midwest CEAC provided services to the Midwest Region that included the states of Illinois, Indiana, Iowa, Kansas, Michigan, Minnesota, Missouri, Nebraska, North Dakota, Ohio, South Dakota, and Wisconsin.

  11. Midwest Transmission Workshop II Summary

    SciTech Connect

    Kevin Bryan

    2002-12-05

    OAK-B135 After introductions of all participants, Abby Arnold, RESOLVE, reviewed the purpose of the meeting and the agenda. The purpose of the workshop was to share the results of the Midwest Independent System Operator (MISO) scenario development for wind and other fuel sources and the corresponding implications for transmission throughout the MISO control area. The workshop agenda is included in Attachment A.

  12. Midwest Grain Processors MGP | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Midwest Grain Processors (MGP) Place: Lakota, Iowa Zip: 50451 Product: Iowa-based bioethanol producer using corn as feedstock. Coordinates: 48.042535, -98.335979 Show Map...

  13. Midwest Biodiesel Producers LLC | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Biodiesel Producers LLC Jump to: navigation, search Name: Midwest Biodiesel Producers LLC Place: Alexandria, South Dakota Zip: 57311 Product: South Dakota-based biodiesel producer....

  14. Midwest Residential Energy Conference | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Residential Energy Conference Midwest Residential Energy Conference March 7, 2017 9:00AM EST to March 8, 2017 5:00PM EST Lexington, Kentucky

  15. Midwest Wind Energy LLC | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Energy LLC Jump to: navigation, search Name: Midwest Wind Energy LLC Place: Chicago, Illinois Zip: 60611 Sector: Wind energy Product: Wind farm developer, owner and operator....

  16. Midwest Residential Energy Conference | Department of Energy

    Energy Saver

    Residential Energy Conference Midwest Residential Energy Conference March 7, 2017 9:00AM EST to March 8, 2017 5:00PM EST Lexington, Kentucky

  17. KTFC Midwest Bible Radio Wind Farm | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Owner KTFC Midwest Bible Radio Energy Purchaser KTFC Midwest Bible Radio Location IA Coordinates 42.4837, -96.3068 Show Map Loading map... "minzoom":false,"mappingservi...

  18. The Midwest Energy Efficiency Alliance | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Midwest Energy Efficiency Alliance Jump to: navigation, search Name: The Midwest Energy Efficiency Alliance Place: Chicago, IL Information About Partnership with NREL Partnership...

  19. DOE - Office of Legacy Management -- Midwest Manufacturing Co...

    Office of Legacy Management (LM)

    Midwest Manufacturing Co - IL 0-04 FUSRAP Considered Sites Site: MIDWEST MANUFACTURING CO (IL.0-04 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated...

  20. Upper Midwest Hydrogen Initiative UMHI | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Midwest Hydrogen Initiative UMHI Jump to: navigation, search Name: Upper Midwest Hydrogen Initiative (UMHI) Place: Minneapolis, Minnesota Zip: 55407 Product: An industry-led,...

  1. Midwest Building Energy Program | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Midwest Building Energy Program Midwest Building Energy Program Building Codes Project for the 2013 Building Technologies Office's Program Peer Review bldgcodes02_paradis_040213.pdf (652.9 KB) More Documents & Publications Stretch/Reach Codes Appliance Standards and Building Codes Energy Code Compliance and Enforcement Best Practices

  2. Midwest Energy Solutions Conference | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energy Solutions Conference Midwest Energy Solutions Conference February 22, 2017 9:00AM EST to February 24, 2017 5:00PM EST Chicago Hilton and Towers Chicago, Illinois

  3. Energy Efficiency as a Resource Regional Report: Midwest Region

    SciTech Connect

    Glatt, Sandy; Harry, Ryan; Shields, Garrett

    2010-06-25

    This Industrial Technologies Program report identifies the amount of energy efficiency potential within key manufacturing industries in the Midwest

  4. Midwest Region Alternative Fuels Project | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Midwest Region Alternative Fuels Project Midwest Region Alternative Fuels Project 2012 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Program Annual Merit Review and Peer Evaluation Meeting arravt056_ti_gilbert_2012_o.pdf (1.37 MB) More Documents & Publications Midwest Region Alternative Fuels Project Midwest Region Alternative Fuels Project DeKalb County/Metropolitan Atlanta Alternative Fuel and Advanced Technology Vehicle Project

  5. The Midwest Regional Carbon Sequestration Partnership (MRCSP)

    SciTech Connect

    James J. Dooley; Robert Dahowski; Casie Davidson

    2005-12-01

    This final report summarizes the Phase I research conducted by the Midwest regional Carbon Sequestration Partnership (MRCSP). The Phase I effort began in October 2003 and the project period ended on September 31, 2005. The MRCSP is a public/private partnership led by Battelle with the mission of identifying the technical, economic, and social issues associated with implementation of carbon sequestration technologies in its seven state geographic region (Indiana, Kentucky, Maryland, Michigan, Ohio, Pennsylvania, and West Virginia) and identifying viable pathways for their deployment. It is one of seven partnerships that together span most of the U.S. and parts of Canada that comprise the U.S. Department of Energy's (DOE's) Regional Carbon Sequestration Program led by DOE's national Energy Technology Laboratory (NETL). The MRCSP Phase I research was carried out under DOE Cooperative Agreement No. DE-FC26-03NT41981. The total value of Phase I was $3,513,513 of which the DOE share was $2,410,967 or 68.62%. The remainder of the cost share was provided in varying amounts by the rest of the 38 members of MRCSP's Phase I project. The next largest cost sharing participant to DOE in Phase I was the Ohio Coal Development Office within the Ohio Air Quality Development Authority (OCDO). OCDO's contribution was $100,000 and was contributed under Grant Agreement No. CDO/D-02-17. In this report, the MRCSP's research shows that the seven state MRCSP region is a major contributor to the U. S. economy and also to total emissions of CO2, the most significant of the greenhouse gases thought to contribute to global climate change. But, the research has also shown that the region has substantial resources for sequestering carbon, both in deep geological reservoirs (geological sequestration) and through improved agricultural and land management practices (terrestrial sequestration). Geological reservoirs, especially deep saline reservoirs, offer the potential to permanently store CO2 for

  6. CHP in the Midwest - Presentation from the July 2010 Advancing Renewables

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    in the Midwest Conference | Department of Energy in the Midwest - Presentation from the July 2010 Advancing Renewables in the Midwest Conference CHP in the Midwest - Presentation from the July 2010 Advancing Renewables in the Midwest Conference This presentation by Recycled Enegy Development (RED) from the "Advancing Renewables in the Midwest Conference" held on July 15, 2010, proposes policy changes that could make the Midwest and the United States a world leader in reducing

  7. MIDWEST REGIONAL CARBON SEQUESTRATION PARTNERSHIP (MRCSP)

    SciTech Connect

    David Ball; Judith Bradbury; Rattan Lal; Larry Wickstrom; Neeraj Gupta; Robert Burns; Bob Dahowski

    2004-04-30

    This is the first semiannual report for Phase I of the Midwest Carbon Sequestration Partnership (MRCSP). The project consists of nine tasks to be conducted over a two year period that started in October 2003. The makeup of the MRCSP and objectives are described. Progress on each of the active Tasks is also described and where possible, for those Tasks at some point of completion, a summary of results is presented.

  8. Marysville, MI Natural Gas Exports to Canada

    Annual Energy Outlook

    Monthly Annual Download Series History Download Series History Definitions, Sources & Notes Definitions, Sources & Notes Show Data By: Data Series Area 2009 2010 2011 2012 2013...

  9. Marysville, MI Natural Gas Exports to Canada

    Annual Energy Outlook

    4,925 22,198 41,964 42,866 35,273 24,583 1996-2014 Pipeline Prices 4.85 4.87 4.48 3.18 3.98 5.45 1996...

  10. Detroit, MI Natural Gas Exports to Canada

    Energy Information Administration (EIA) (indexed site)

    2010 2011 2012 2013 2014 2015 View History Pipeline Volumes 79 19 0 165 188 0 1996-2015 Pipeline Prices 8.37 5.17 -- 4.44 5.26 -- 1996

  11. Detroit, MI Natural Gas Exports to Canada

    Energy Information Administration (EIA) (indexed site)

    275 43,690 50,347 50,439 46,981 37,528 1996-2015 Pipeline Prices 4.69 4.26 3.10 4.04 5.36 2.91

  12. Midwest States Save Energy Now Partnership Program | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Midwest States Save Energy Now Partnership Program Midwest States Save Energy Now Partnership Program Map highlighting the Midwest states: Minnesota, Wisconsin, Michigan, Iowa, Illinois, Indiana, Missouri, and Kentucky The industrial sector accounts for approximately one-third of all energy consumed in the United States each year. The U.S. Department of Energy's (DOE's) Advanced Manufacturing Office (AMO; formerly the Industrial Technologies Program) developed multiple resources and a best

  13. Petrich receives ACS Midwest Award | The Ames Laboratory

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Petrich receives ACS Midwest Award [PHOTO]Jacob Petrich Jacob Petrich, an Ames Laboratory scientist and professor of chemistry at Iowa State University, has been named the winner of the 2016 ACS Midwest Award from the American Chemical Society. Petrich is studying specialized analytical techniques for understanding chemical phenomena and solar energy conversion materials in the Ames Laboratory's Chemical and Biological Sciences division. The ACS Midwest Award was established in 1944 to publicly

  14. Midwest Research Institute Receives Contract Extension to Manage NREL -

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    News Releases | NREL Midwest Research Institute Receives Contract Extension to Manage NREL February 9, 2004 Golden, Colo. - Midwest Research Institute (MRI) in Kansas City has received a four-year contract extension to manage and operate the U.S. Department of Energy's National Renewable Energy Laboratory (NREL). The NREL contract was last competed in 1998 and this extends MRI's management for the full 10 years. Midwest Research Institute has managed NREL since the Laboratory's founding as

  15. 2017 Midwest Cleantech University Prize for Student Entrepreneurs Now Open!

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    | Department of Energy 2017 Midwest Cleantech University Prize for Student Entrepreneurs Now Open! 2017 Midwest Cleantech University Prize for Student Entrepreneurs Now Open! October 25, 2016 - 6:57pm Addthis Applications are open for university-based cleantech companies in the Midwest to compete in Clean Energy Trust's (CET's) regional Cleantech University Prize (UP) competition. Cleantech UP, sponsored by the Department of Energy's Office of Energy Efficiency and Renewable Energy (EERE),

  16. Midwest Renewable Energy Services LLC | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Services LLC Jump to: navigation, search Name: Midwest Renewable Energy Services LLC Place: Florida Zip: FL 33408 Sector: Services, Wind energy Product: MRE Services provides...

  17. Midwest Ethanol Producers Inc MEPI | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Ethanol Producers Inc MEPI Jump to: navigation, search Name: Midwest Ethanol Producers Inc (MEPI) Place: O'Neill, Nebraska Zip: 68763 Product: Focused on ethanol production....

  18. Midwest Renewable Energy Credits LLC | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Credits LLC Jump to: navigation, search Name: Midwest Renewable Energy Credits LLC Place: Florida Sector: Renewable Energy Product: MRE Credits markets renewable energy credits to...

  19. Midwest Renewable Energy Projects LLC | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Projects LLC Jump to: navigation, search Name: Midwest Renewable Energy Projects LLC Place: Florida Zip: FL 33408 Sector: Renewable Energy, Wind energy Product: MRE Projects LLC is...

  20. Midwest Energy Inc. Smart Grid Project | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    allows Midwest to improve power system models and analysis tools, increasing reliability of grid operations.3 Equipment 9 Relay-based Phasor Measurement Units...

  1. EERE Leadership Discusses Energy Innovation in Midwest | Department...

    Energy.gov [DOE] (indexed site)

    EERE Leadership Discusses Energy Innovation in Midwest Cori Sue Morris Communications ... game-changing research and innovation needed to advance America's clean energy economy. ...

  2. Clean Energy Manufacturing Initiative Midwest Regional Summit: Lightweighting Breakout Session Summary

    Energy.gov [DOE]

    Clean Energy Manufacturing Initiative Midwest Regional Summit: Lightweighting Breakout Session Summary June 21, 2013

  3. State and Local Code Implementation: Midwest Region - 2014 BTO Peer Review

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    | Department of Energy Midwest Region - 2014 BTO Peer Review State and Local Code Implementation: Midwest Region - 2014 BTO Peer Review Presenter: Isaac Elencave, Midwest Energy Efficiency Alliance View the Presentation State and Local Code Implementation: Midwest Region - 2014 BTO Peer Review (637.53 KB) More Documents & Publications Midwest Building Energy Program Technical Assistance: Increasing Code Compliance - 2014 BTO Peer Review DOE Codes Program Overview - 2015 Peer Review

  4. MIE Regional Climate Change Impact Webinar Series: Midwest

    Energy.gov [DOE]

    The U.S. Department of Energy's (DOE's) Minorities in Energy Initiative (MIE) is hosting a webinar on Midwest impacts of climate change on minority and tribal communities featuring presentations by...

  5. ,"Midwest Region Underground Natural Gas Storage - All Operators...

    Energy Information Administration (EIA) (indexed site)

    ...282016 11:29:21 AM" "Back to Contents","Data 1: Total Underground Storage" ... Region Natural Gas in Underground Storage (Base Gas) (MMcf)","Midwest Region Natural Gas ...

  6. Midwest superconductivity consortium. 1993 Progress report

    SciTech Connect

    Not Available

    1994-01-01

    The Midwest Superconductivity Consortium, MISCON, in the fourth year of operations further strengthened its mission to advance the science and understanding of high T{sub c} superconductivity. The goals of the organization and the individual projects continue to reflect the current needs for new knowledge in the field and the unique capabilities of the institutions involved. Group efforts and cooperative laboratory interactions to achieve the greatest possible synergy under the Consortium continue to be emphasized. Industrial affiliations coupled with technology transfer initiatives were expanded. Activities of the participants during the past year achieved an interactive and high level of performance. The number of notable achievements in the field contributed by Consortium investigators increased. The programmatic research continues to focus upon key materials-related problems in two areas. The first area has a focus upon {open_quotes}Synthesis and Processing{close_quotes} while the second is centered around {open_quotes}Limiting Features in Transport Properties of High T{sub c} Materials{close_quotes}.

  7. Standardized Retrofit Packages - What Works to Meet Consistent Levels of Performance: Midwest Energy Efficiency Alliance

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Building America Webinar Series Standardized Retrofit Packages - What Works to Meet Consistent Levels of Performance: Midwest Energy Efficiency Alliance Scott Yee March 19 th , 2014 1 Midwest Energy Efficiency Alliance (MEEA) Midwest Energy Efficiency Alliance 2 MEEA is a collaborative network whose purpose is to advance energy efficiency to support sustainable economic development and environmental preservation. Partnership for Advanced Residential Retrofit (PARR) Midwest Energy Efficiency

  8. MIE Regional Climate Change Impact Webinar Series: Midwest

    Energy.gov [DOE]

    The U.S. Department of Energy's (DOE's) Minorities in Energy Initiative (MIE) is hosting a webinar on midwest impacts of climate change on minority and tribal communities featuring presentations by nationally recognized policymakers, researchers, and educators. Speakers will highlight growing opportunities for workforce development, clean energy advancement, and increases in domestic energy production.

  9. Measurement of the direct <mi>CP> -violating parameter <mi>Ami><mi>CP> in the decay <mi>D>+<mi>Kmi>-<mimi>+<mi>π>+

    SciTech Connect

    Abazov, V. M.; Abbott, B.; Acharya, B. S.; Adams, M.; Adams, T.; Agnew, J. P.; Alexeev, G. D.; Alkhazov, G.; Alton, A.; Askew, A.; Atkins, S.; Augsten, K.; Avila, C.; Badaud, F.; Bagby, L.; Baldin, B.; Bandurin, D. V.; Banerjee, S.; Barberis, E.; Baringer, P.; Bartlett, J. F.; Bassler, U.; Bazterra, V.; Bean, A.; Begalli, M.; Bellantoni, L.; Beri, S. B.; Bernardi, G.; Bernhard, R.; Bertram, I.; Besançon, M.; Beuselinck, R.; Bhat, P. C.; Bhatia, S.; Bhatnagar, V.; Blazey, G.; Blessing, S.; Bloom, K.; Boehnlein, A.; Boline, D.; Boos, E. E.; Borissov, G.; Borysova, M.; Brandt, A.; Brandt, O.; Brock, R.; Bross, A.; Brown, D.; Bu, X. B.; Buehler, M.; Buescher, V.; Bunichev, V.; Burdin, S.; Buszello, C. P.; Camacho-Pérez, E.; Casey, B. C. K.; Castilla-Valdez, H.; Caughron, S.; Chakrabarti, S.; Chan, K. M.; Chandra, A.; Chapon, E.; Chen, G.; Cho, S. W.; Choi, S.; Choudhary, B.; Cihangir, S.; Claes, D.; Clutter, J.; Cooke, M.; Cooper, W. E.; Corcoran, M.; Couderc, F.; Cousinou, M. -C.; Cutts, D.; Das, A.; Davies, G.; de Jong, S. J.; De La Cruz-Burelo, E.; Déliot, F.; Demina, R.; Denisov, D.; Denisov, S. P.; Desai, S.; Deterre, C.; DeVaughan, K.; Diehl, H. T.; Diesburg, M.; Ding, P. F.; Dominguez, A.; Dubey, A.; Dudko, L. V.; Duperrin, A.; Dutt, S.; Eads, M.; Edmunds, D.; Ellison, J.; Elvira, V. D.; Enari, Y.; Evans, H.; Evdokimov, V. N.; Fauré, A.; Feng, L.; Ferbel, T.; Fiedler, F.; Filthaut, F.; Fisher, W.; Fisk, H. E.; Fortner, M.; Fox, H.; Fuess, S.; Garbincius, P. H.; Garcia-Bellido, A.; García-González, J. A.; Gavrilov, V.; Geng, W.; Gerber, C. E.; Gershtein, Y.; Ginther, G.; Gogota, O.; Golovanov, G.; Grannis, P. D.; Greder, S.; Greenlee, H.; Grenier, G.; Gris, Ph.; Grivaz, J. -F.; Grohsjean, A.; Grünendahl, S.; Grünewald, M. W.; Guillemin, T.; Gutierrez, G.; Gutierrez, P.; Haley, J.; Han, L.; Harder, K.; Harel, A.; Hauptman, J. M.; Hays, J.; Head, T.; Hebbeker, T.; Hedin, D.; Hegab, H.; Heinson, A. P.; Heintz, U.; Hensel, C.; Heredia-De La Cruz, I.; Herner, K.; Hesketh, G.; Hildreth, M. D.; Hirosky, R.; Hoang, T.; Hobbs, J. D.; Hoeneisen, B.; Hogan, J.; Hohlfeld, M.; Holzbauer, J. L.; Howley, I.; Hubacek, Z.; Hynek, V.; Iashvili, I.; Ilchenko, Y.; Illingworth, R.; Ito, A. S.; Jabeen, S.; Jaffré, M.; Jayasinghe, A.; Jeong, M. S.; Jesik, R.; Jiang, P.; Johns, K.; Johnson, E.; Johnson, M.; Jonckheere, A.; Jonsson, P.; Joshi, J.; Jung, A. W.; Juste, A.; Kajfasz, E.; Karmanov, D.; Katsanos, I.; Kaur, M.; Kehoe, R.; Kermiche, S.; Khalatyan, N.; Khanov, A.; Kharchilava, A.; Kharzheev, Y. N.; Kiselevich, I.; Kohli, J. M.; Kozelov, A. V.; Kraus, J.; Kumar, A.; Kupco, A.; Kurča, T.; Kuzmin, V. A.; Lammers, S.; Lebrun, P.; Lee, H. S.; Lee, S. W.; Lee, W. M.; Lei, X.; Lellouch, J.; Li, D.; Li, H.; Li, L.; Li, Q. Z.; Lim, J. K.; Lincoln, D.; Linnemann, J.; Lipaev, V. V.; Lipton, R.; Liu, H.; Liu, Y.; Lobodenko, A.; Lokajicek, M.; Lopes de Sa, R.; Luna-Garcia, R.; Lyon, A. L.; Maciel, A. K. A.; Madar, R.; Magaña-Villalba, R.; Malik, S.; Malyshev, V. L.; Mansour, J.; Martínez-Ortega, J.; McCarthy, R.; McGivern, C. L.; Meijer, M. M.; Melnitchouk, A.; Menezes, D.; Mercadante, P. G.; Merkin, M.; Meyer, A.; Meyer, J.; Miconi, F.; Mondal, N. K.; Mulhearn, M.; Nagy, E.; Narain, M.; Nayyar, R.; Neal, H. A.; Negret, J. P.; Neustroev, P.; Nguyen, H. T.; Nunnemann, T.; Orduna, J.; Osman, N.; Osta, J.; Pal, A.; Parashar, N.; Parihar, V.; Park, S. K.; Partridge, R.; Parua, N.; Patwa, A.; Penning, B.; Perfilov, M.; Peters, Y.; Petridis, K.; Petrillo, G.; Pétroff, P.; Pleier, M. -A.; Podstavkov, V. M.; Popov, A. V.; Prewitt, M.; Price, D.; Prokopenko, N.; Qian, J.; Quadt, A.; Quinn, B.; Ratoff, P. N.; Razumov, I.; Ripp-Baudot, I.; Rizatdinova, F.; Rominsky, M.; Ross, A.; Royon, C.; Rubinov, P.; Ruchti, R.; Sajot, G.; Sánchez-Hernández, A.; Sanders, M. P.; Santos, A. S.; Savage, G.; Savitskyi, M.; Sawyer, L.; Scanlon, T.; Schamberger, R. D.; Scheglov, Y.; Schellman, H.; Schwanenberger, C.; Schwienhorst, R.; Sekaric, J.; Severini, H.; Shabalina, E.; Shary, V.; Shaw, S.; Shchukin, A. A.; Simak, V.; Skubic, P.; Slattery, P.; Smirnov, D.; Snow, G. R.; Snow, J.; Snyder, S.; Söldner-Rembold, S.; Sonnenschein, L.; Soustruznik, K.; Stark, J.; Stoyanova, D. A.; Strauss, M.; Suter, L.; Svoisky, P.; Titov, M.; Tokmenin, V. V.; Tsai, Y. -T.; Tsybychev, D.; Tuchming, B.; Tully, C.; Uvarov, L.; Uvarov, S.; Uzunyan, S.; Van Kooten, R.; van Leeuwen, W. M.; Varelas, N.; Varnes, E. W.; Vasilyev, I. A.; Verkheev, A. Y.; Vertogradov, L. S.; Verzocchi, M.; Vesterinen, M.; Vilanova, D.; Vokac, P.; Wahl, H. D.; Wang, M. H. L. S.; Warchol, J.; Watts, G.; Wayne, M.; Weichert, J.; Welty-Rieger, L.; Williams, M. R. J.; Wilson, G. W.; Wobisch, M.; Wood, D. R.; Wyatt, T. R.; Xie, Y.; Yamada, R.; Yang, S.; Yasuda, T.; Yatsunenko, Y. A.; Ye, W.; Ye, Z.; Yin, H.; Yip, K.; Youn, S. W.; Yu, J. M.; Zennamo, J.; Zhao, T. G.; Zhou, B.; Zhu, J.; Zielinski, M.; Zieminska, D.; Zivkovic, L.

    2014-12-01

    We measure the direct mi>Cmi>mi>P>-violating parameter mi>Ami>mi>Cmi>mi>Pmi> for the decay of the charged charm meson, mi>Dmi>+mi>Kmi>-mi>πmi>+mi>πmi>+ (and charge conjugate), using the full 10.4 mi>fbmi>-1 sample of mi>p>mi>p>¯ collisions at mi>smi>=1.96 mi>TeVmi> collected by the D0 detector at the Fermilab Tevatron collider. We extract the raw reconstructed charge asymmetry by fitting the invariant mass distributions for the sum and difference of charge-specific samples. This quantity is then corrected for detector-related asymmetries using data-driven methods and for possible physics asymmetries (from mi>B>mi>D

  10. Midwest Region Natural Gas Working Underground Storage (Billion Cubic Feet)

    Energy Information Administration (EIA) (indexed site)

    Midwest Region Natural Gas Working Underground Storage (Billion Cubic Feet) Midwest Region Natural Gas Working Underground Storage (Billion Cubic Feet) Year-Month Week 1 Week 2 Week 3 Week 4 Week 5 End Date Value End Date Value End Date Value End Date Value End Date Value 2010-Jan 01/01 900 01/08 820 01/15 750 01/22 710 01/29 661 2010-Feb 02/05 604 02/12 552 02/19 502 02/26 464 2010-Mar 03/05 433 03/12 422 03/19 419 03/26 410 2010-Apr 04/02 410 04/09 429 04/16 444 04/23 462 04/30 480 2010-May

  11. Midwest Producing Region Natural Gas in Underground Storage - Change in

    Energy Information Administration (EIA) (indexed site)

    Working Gas from Same Month Previous Year (Percent) Midwest Producing Region Natural Gas in Underground Storage - Change in Working Gas from Same Month Previous Year (Percent) Midwest Producing Region Natural Gas in Underground Storage - Change in Working Gas from Same Month Previous Year (Percent) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2015 37.50 45.20 77.20 72.70 38.10 19.90 9.40 5.50 4.00 4.60 12.20 15.70 2016 23.70 75.90 115.20 82.90 53.00 34.90 21.80 10.60 - = No Data

  12. Forensic Science Education Programs in the Midwest | The Ames Laboratory

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Science Education Programs in the Midwest Carroll University Bachelor of Science Degree (B.S.), Chemistry Major with a Forensic Science emphasis Chemistry Program | Forensic Science emphasis Columbia College of Missouri Bachelor of Science (B.S.) Degree in Forensic Science Forensic Science Program Indiana University-Purdue University Indianapolis Bachelor of Science (B.S.) and Master of Science (M.S.) Degree in Forensic Science Forensic and Investigative Sciences Program Iowa State University

  13. MIDWEST REGIONAL CARBON SEQUESTRATION PARTNERSHIP (MRCSP) MANAGING CLIMATE CHANGE AND SECURING A FUTURE FOR THE MIDWEST'S INDUSTRIAL BASE

    SciTech Connect

    David Ball; Robert Burns; Judith Bradbury; Bob Dahowski; Casie Davidson; James Dooley; Neeraj Gupta; Rattan Lal; Larry Wickstrom

    2005-04-29

    This is the third semiannual report for Phase I of the Midwest Carbon Sequestration Partnership (MRCSP). The project consists of nine tasks to be conducted over a two-year period that started in October 2003. The makeup of the MRCSP and objectives are described. Progress on each of the active Tasks is also described and where possible, for those Tasks at some point of completion, a summary of results is presented.

  14. Future of Clean Energy in the Midwest - Joint Center for Energy...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    October 21, 2014, Videos Future of Clean Energy in the Midwest David Danielson, Assistant Secretary for the Energy Efficiency and Renewable Energy for the Department of Energy; Amy ...

  15. Midwest Energy (Gas and Electric)- How$mart Energy Efficiency Finance Program

    Energy.gov [DOE]

    Midwest Energy offers its residential and small commercial electricity and natural gas customers in good standing a way to finance energy efficiency improvements on eligible properties. Under the...

  16. Conergy Canada | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Canada Jump to: navigation, search Name: Conergy Canada Place: Edmonton, Alberta, Canada Zip: T5S 2X3 Sector: Solar Product: Canada-based manufacturer of solar products....

  17. Marysville, MI Natural Gas Pipeline Imports From Canada (Dollars per

    Energy Information Administration (EIA) (indexed site)

    Thousand Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 4.85 4.76 4.36 4.62 4.73 4.70 4.74 4.75 4.21 3.83 3.85 3.79 2012 3.29 3.05 2.61 2.35 2.68 2.64 3.07 3.16 3.14 3.60 3.93 4.22 2013 3.63 3.65 4.57 4.70 4.22 4.17 3.79 4.78 2014 5.52 23.30 24.73 4.80 4.99 4.06 4.09 3.92 4.51 4.03 2015 3.74 2.89 3.07 2.86 2.94 3.05 3.11 2.63 2.29 2.03 2016 2.61 1.92 1.91 1.90 2.52 2.87 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of

  18. Detroit, MI Natural Gas Pipeline Imports From Canada (Million...

    Energy Information Administration (EIA) (indexed site)

    Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 8 11 2013 16 140 24 10 2014 188 - No Data Reported; -- Not Applicable; NA Not Available; W Withheld to avoid ...

  19. Sault St. Marie, MI Natural Gas Exports to Canada

    Energy Information Administration (EIA) (indexed site)

    4,011 9,555 24,913 16,288 4,457 6,188 1999-2015 Pipeline Prices 5.27 4.23 3.20 4.04 6.01 3.47 1999

  20. St. Clair, MI Natural Gas Pipeline Imports From Canada (Dollars...

    Energy Information Administration (EIA) (indexed site)

    Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 3.04 3.16 2.07 2.62 2000's 4.45 4.54 3.19 5.84 6.50 9.93 7.44 6.97 10.03 5.10 2010's 4.97 4.29 ...

  1. St. Clair, MI Natural Gas Pipeline Exports to Canada (Dollars...

    Energy Information Administration (EIA) (indexed site)

    Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 4.84 4.64 4.44 4.67 4.73 4.83 4.72 4.60 4.26 4.03 3.93 3.70 2012 3.34 3.00 2.64 2.30 2.54 2.67 3.11 3.18 3.09 3.55 4.06 ...

  2. St. Clair, MI Natural Gas Pipeline Imports From Canada (Million...

    Energy Information Administration (EIA) (indexed site)

    Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 123 237 33 91 238 1,469 571 38 1,605 552 270 2012 51 42 2,029 475 370 52 45 69 221 177 2013 884 1,562 1,422 2 26 151 211 ...

  3. Detroit, MI Natural Gas Pipeline Exports to Canada (Million Cubic...

    Energy Information Administration (EIA) (indexed site)

    Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 30,410 31,080 24,908 25,049 2000's 36,007 35,644 7,431 19,737 40,030 40,255 22,156 22,904 27,220 ...

  4. Marysville, MI Natural Gas Pipeline Imports From Canada (Million...

    Energy Information Administration (EIA) (indexed site)

    Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 1,408 2,674 212 579 179 606 34 642 270 1,367 826 1,150 2012 326 264 147 899 1,654 1,086 217 801 1,053 1,472 121 61 2013 ...

  5. Detroit, MI Natural Gas Pipeline Imports From Canada (Million...

    Energy Information Administration (EIA) (indexed site)

    Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 14,901 11,501 10,925 7,671 2000's 6,171 405 1,948 2,514 1,117 0 0 81 753 21 2010's 79 19 0 165

  6. Detroit, MI Natural Gas Pipeline Exports to Canada (Million Cubic...

    Energy Information Administration (EIA) (indexed site)

    Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 3,465 2,693 3,676 3,988 3,357 3,437 765 3,916 4,318 4,473 4,851 4,752 2012 5,562 5,372 5,253 3,745 3,354 2,811 2,935 3,822 ...

  7. Marysville, MI Natural Gas Pipeline Exports to Canada (Million...

    Energy Information Administration (EIA) (indexed site)

    Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 4,338 5,323 4,952 3,361 3,295 2,761 2,838 2,182 2,061 2,644 3,085 5,122 2012 6,067 6,721 3,354 3,404 2,923 1,986 2,475 ...

  8. St. Clair, MI Natural Gas Pipeline Exports to Canada (Dollars...

    Energy Information Administration (EIA) (indexed site)

    Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 3.13 2.51 2.23 2.51 2000's 3.73 3.82 3.42 6.13 6.56 7.77 7.39 7.24 8.96 4.62 2010's 4.86 4.45 ...

  9. St. Clair, MI Natural Gas Pipeline Imports From Canada (Dollars...

    Energy Information Administration (EIA) (indexed site)

    Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 4.56 4.61 4.11 4.74 4.67 4.64 4.68 4.30 3.91 3.91 3.73 2012 2.90 2.78 2.34 2.63 2.52 3.03 3.08 3.24 4.02 3.97 2013 3.75 ...

  10. St. Clair, MI Natural Gas Pipeline Exports to Canada (Million...

    Energy Information Administration (EIA) (indexed site)

    Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 74,025 68,809 83,796 62,851 68,731 59,044 56,015 56,094 66,775 52,380 65,815 66,723 2012 62,390 62,442 72,035 61,364 ...

  11. St. Clair, MI Natural Gas Exports to Canada

    Gasoline and Diesel Fuel Update

    612,369 650,590 781,058 754,494 582,509 478,645 1996-2014 Pipeline Prices 4.62 4.86 4.45 3.11 4.07 6.39 1996...

  12. Marysville, MI Natural Gas Pipeline Imports From Canada (Million...

    Gasoline and Diesel Fuel Update

    Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 1,408 2,674 212 579 179 606 34 642 270 1,367 826 1,150 2012 326 264 147 899 1,654 1,086 217 801 1,053 1,472 121 61 2013...

  13. St. Clair, MI Natural Gas Pipeline Imports From Canada (Million...

    Annual Energy Outlook

    Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 123 237 33 91 238 1,469 571 38 1,605 552 270 2012 51 42 2,029 475 370 52 45 69 221 177 2013 884 1,562 1,422 2 26 151 211...

  14. Marysville, MI Natural Gas Pipeline Exports to Canada (Million...

    Gasoline and Diesel Fuel Update

    Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 4,338 5,323 4,952 3,361 3,295 2,761 2,838 2,182 2,061 2,644 3,085 5,122 2012 6,067 6,721 3,354 3,404 2,923 1,986 2,475...

  15. St. Clair, MI Natural Gas Exports to Canada

    Annual Energy Outlook

    6,544 5,591 5,228 3,531 6,019 16,409 1996-2014 Pipeline Prices 5.10 4.97 4.29 2.64 3.96 8.80 1996...

  16. Midwest Region Natural Gas Total Underground Storage Capacity (Million

    Energy Information Administration (EIA) (indexed site)

    Cubic Feet) Total Underground Storage Capacity (Million Cubic Feet) Midwest Region Natural Gas Total Underground Storage Capacity (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2013 2,720,465 2,720,436 2,720,436 2,720,436 2,720,881 2,720,881 2,721,231 2,721,231 2,721,231 2,721,231 2,721,231 2,721,231 2014 2,721,231 2,721,231 2,721,231 2,721,231 2,721,231 2,721,231 2,721,231 2,721,231 2,721,231 2,723,336 2,725,497 2,725,535 2015 2,727,987 2,727,987 2,727,987

  17. Midwest Region Natural Gas Underground Storage Withdrawals (Million Cubic

    Energy Information Administration (EIA) (indexed site)

    Feet) Gas Underground Storage Withdrawals (Million Cubic Feet) Midwest Region Natural Gas Underground Storage Withdrawals (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2013 245,791 202,093 152,913 32,351 4,462 2,642 7,377 4,478 2,266 14,497 103,084 248,313 2014 303,499 226,394 125,284 24,726 2,965 1,475 2,904 3,200 2,019 8,158 110,419 134,700 2015 243,669 277,575 114,546 18,265 3,379 2,610 6,047 3,637 2,234 4,518 49,679 115,761 2016 230,165 164,964 82,682 32,304

  18. Application experiences with distributed resources in the Midwest

    SciTech Connect

    O`Sullivan, J.B.; Jacobs, K.; Guzy, L.

    1998-12-31

    Distributed generation consists of the use of integrated or stand-alone natural gas or liquid fueled power generation equipment. These distributed resources (DR) may provide power in the 5-kW to 50-MW range and can provide power directly to the customer, thereby potentially deferring additional transmission and distribution systems upgrades by the utility and improving power quality and reliability for the customer. Compact, technically advanced units in a variety of technologies presently available include diesel engines, lean burning gas fired internal combustion engine generator sets, cogeneration packages, small microturbines, and fuel cells. This class of resources has the potential to provide a cost effective, reliable, addition to a utility`s generating resource mix and is once again gaining favor in era characterized both by uncertainty and opportunity. Strategic deployment of these resources can also eliminate or delay expensive central plant capacity additions. Installations may be tailored to meet customer technical and financial requirements with projects being developed by utilities on customer sites as well as by Independent Power Producers and others. Economic constraints as well as key environmental and operating issues must be understood and clarified for those seeking to capitalize on this approach. As the first phase of a project with the objective of developing a best practices approach to implementing DR, EPRI`s project Application Experiences with Distributed Resources in the Midwest examined these issues. This report contains the results of an in-depth technical survey, which was given to distributed resource sites throughout the Midwest. Aspects of DR projects involving electrical interconnection, siting and permitting, operations and maintenance and various operating practices are examined.

  19. "Table HC12.1 Housing Unit Characteristics by Midwest Census Region, 2005"

    Energy Information Administration (EIA) (indexed site)

    Housing Unit Characteristics by Midwest Census Region, 2005" " Million U.S. Housing Units" ,,"Midwest Census Region" ,"U.S. Housing Units (millions)" ,,,"Census Division" ,,"Total Midwest" "Housing Unit Characteristics",,,"East North Central","West North Central" "Total",111.1,25.6,17.7,7.9 "Urban/Rural Location (as Self-Reported)" "City",47.1,9.7,7.3,2.4

  20. "Table HC12.11 Home Electronics Characteristics by Midwest Census Region, 2005"

    Energy Information Administration (EIA) (indexed site)

    1 Home Electronics Characteristics by Midwest Census Region, 2005" " Million U.S. Housing Units" ,,"Midwest Census Region" ,"U.S. Housing Units (millions)" ,,,"Census Division" ,,"Total Midwest" "Home Electronics Characteristics",,,"East North Central","West North Central" "Total",111.1,25.6,17.7,7.9 "Personal Computers" "Do Not Use a Personal Computer ",35.5,8.1,5.6,2.5 "Use a

  1. "Table HC12.13 Lighting Usage Indicators by Midwest Census Region, 2005"

    Energy Information Administration (EIA) (indexed site)

    3 Lighting Usage Indicators by Midwest Census Region, 2005" " Million U.S. Housing Units" ,,"Midwest Census Region" ,"U.S. Housing Units (millions)" ,,,"Census Division" ,,"Total Midwest" "Lighting Usage Indicators",,,"East North Central","West North Central" "Total U.S. Housing Units",111.1,25.6,17.7,7.9 "Indoor Lights Turned On During Summer" "Number of Lights Turned On"

  2. "Table HC12.2 Living Space Characteristics by Midwest Census Region, 2005"

    Energy Information Administration (EIA) (indexed site)

    2 Living Space Characteristics by Midwest Census Region, 2005" " Million U.S. Housing Units" ,,"Midwest Census Region" ,"U.S. Housing Units (millions)" ,,,"Census Division" ,,"Total Midwest" "Living Space Characteristics",,,"East North Central","West North Central" "Total",111.1,25.6,17.7,7.9 "Floorspace (Square Feet)" "Total Floorspace1" "Fewer than

  3. "Table HC12.4 Space Heating Characteristics by Midwest Census Region, 2005"

    Energy Information Administration (EIA) (indexed site)

    4 Space Heating Characteristics by Midwest Census Region, 2005" " Million U.S. Housing Units" ,,"Midwest Census Region" ,"U.S. Housing Units (millions)" ,,,"Census Division" ,,"Total Midwest" "Space Heating Characteristics",,,"East North Central","West North Central" "Total",111.1,25.6,17.7,7.9 "Do Not Have Space Heating Equipment",1.2,"Q","Q","N" "Have Main

  4. "Table HC12.6 Air Conditioning Characteristics by Midwest Census Region, 2005"

    Energy Information Administration (EIA) (indexed site)

    6 Air Conditioning Characteristics by Midwest Census Region, 2005" " Million U.S. Housing Units" ,,"Midwest Census Region" ,"U.S. Housing Units (millions)" ,,,"Census Division" ,,"Total Midwest" "Air Conditioning Characteristics",,,"East North Central","West North Central" "Total",111.1,25.6,17.7,7.9 "Do Not Have Cooling Equipment",17.8,2.1,1.8,0.3 "Have Cooling

  5. "Table HC12.9 Home Appliances Characteristics by Midwest Census Region, 2005"

    Energy Information Administration (EIA) (indexed site)

    2.9 Home Appliances Characteristics by Midwest Census Region, 2005" " Million U.S. Housing Units" ,,"Midwest Census Region" ,"U.S. Housing Units (millions)" ,,,"Census Division" ,,"Total Midwest" "Home Appliances Characteristics",,,"East North Central","West North Central" "Total U.S.",111.1,25.6,17.7,7.9 "Cooking Appliances" "Conventional Ovens" "Use an

  6. Pangaea Ventures Ltd (Canada) | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Canada) Jump to: navigation, search Logo: Pangaea Ventures Ltd (Canada) Name: Pangaea Ventures Ltd (Canada) Address: 1500 West Georgia Street, Suite 1580 Place: Vancouver, Canada...

  7. Fact #756: December 3, 2012 Midwest Produces Two-Thirds of All Light Vehicles

    Energy.gov [DOE]

    Although there are many new vehicle assembly plants located in the South, the Midwest region continues to produce about two-thirds of all light vehicles. The year 2009 was the low point for vehicle...

  8. Coordination of Retail Demand Response with Midwest ISO Markets

    SciTech Connect

    Bharvirkar, Ranjit; Bharvirkar, Ranjit; Goldman, Charles; Heffner, Grayson; Sedano, Richard

    2008-05-27

    The Organization of Midwest ISO States (OMS) launched the Midwest Demand Resource Initiative (MWDRI) in 2007 to identify barriers to deploying demand response (DR) resources in the Midwest Independent System Operator (MISO) region and develop policies to overcome them. The MWDRI stakeholders decided that a useful initial activity would be to develop more detailed information on existing retail DR programs and dynamic pricing tariffs, program rules, and utility operating practices. This additional detail could then be used to assess any"seams issues" affecting coordination and integration of retail DR resources with MISO's wholesale markets. Working with state regulatory agencies, we conducted a detailed survey of existing DR programs, dynamic pricing tariffs, and their features in MISO states. Utilities were asked to provide information on advance notice requirements to customers, operational triggers used to call events (e.g. system emergencies, market conditions, local emergencies), use of these DR resources to meet planning reserves requirements, DR resource availability (e.g., seasonal, annual), participant incentive structures, and monitoring and verification (M&V) protocols. This report describes the results of this comprehensive survey and discusses policy implications for integrating legacy retail DR programs and dynamic pricing tariffs into organized wholesale markets. Survey responses from 37 MISO members and 4 non-members provided information on 141 DR programs and dynamic pricing tariffs with a peak load reduction potential of 4,727 MW of retail DR resource. Major findings of this study area:- About 72percent of available DR is from interruptible rate tariffs offered to large commercial and industrial customers, while direct load control (DLC) programs account for ~;;18percent. Almost 90percent of the DR resources included in this survey are provided by investor-owned utilities. - Approximately, 90percent of the DR resources are available with less than

  9. Threatened and endangered fish and wildlife of the midwest

    SciTech Connect

    Schafer, D.W.; Robeck, K.E.

    1980-06-01

    This report contains information of federally-listed endangered and/or threatened fish and wildlife occurring in the midwestern states of Illinois, Indiana, Iowa, Kansas, Michigan, Minnesota, Missouri, Nebraska, Ohio, and Wisconsin. The information was compiled as a support document for the Regional Issue Identification and Assessment (RIIA) project sponsored by the Regional Assessments Division of the Office of Technology Impacts within the Department of Energy. The information on midwestern endangered species distribution, habitats, and reasons for population decline included in this document are designed to help assess the potential for adverse impacts if energy activities are sited within the general range of an endangered species. It is hoped that this document will thereby enhance the reliability of one portion of energy-related assessments performed in the Midwest. This report considers only those species listed prior to October 1979 as endangered and/or threatened in the federal endangered species list published in the Federal Register and that have been known to occur in the region in the last 20 years.

  10. US ENC MI Site Consumption

    Energy Information Administration (EIA) (indexed site)

    MI Site Consumption million Btu $0 $500 $1,000 $1,500 $2,000 $2,500 US ENC MI Expenditures dollars ALL ENERGY average per household (excl. transportation) 0 2,000 4,000 6,000 8,000 10,000 12,000 US ENC MI Site Consumption kilowatthours $0 $250 $500 $750 $1,000 $1,250 $1,500 US ENC MI Expenditures dollars ELECTRICITY ONLY average per household * Michigan households use 123 million Btu of energy per home, 38% more than the U.S. average. * High consumption, combined with low costs for heating fuels

  11. "Table HC12.8 Water Heating Characteristics by Midwest Census Region, 2005"

    Energy Information Administration (EIA) (indexed site)

    8 Water Heating Characteristics by Midwest Census Region, 2005" " Million U.S. Housing Units" ,,"Midwest Census Region" ,"U.S. Housing Units (millions)" ,,,"Census Division" ,,"Total Midwest" "Water Heating Characteristics",,,"East North Central","West North Central" "Total",111.1,25.6,17.7,7.9 "Number of Water Heaters" "1.",106.3,24.5,17.1,7.4 "2 or More",3.7,0.9,0.5,0.4

  12. Vancouver, Canada: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    in Vancouver, Canada 4 References Registered Research Institutions in Vancouver, Canada NRC Institute for Fuel Cell Innovation Registered Energy Companies in Vancouver, Canada...

  13. Free Energy International Canada | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    International Canada Jump to: navigation, search Name: Free Energy International (Canada) Place: Richmond, British Columbia, Canada Sector: Geothermal energy, Solar Product:...

  14. The Canada connection

    SciTech Connect

    Bright, D.; Salaff, S.

    1995-03-01

    A big boost for wholesale electricity wheeling between Canada and the United States could be the consolidation and final approval of the Western Regional Transmission Association (WRTA), expected later this year, and the Northwest Regional Transmission Association (NWRTA). WRTA culd become the first US regional transmission group (RTG) approved by the ederal Energy Regulatory Commission (FERC). Several US utilities and independent energy players would be joined in this pioneering RTG by western Canadian firms - a major advance for Canada-US electricity cooperation and competition. Curently, British Columbia and Alberta are leading Canada toward open transmission access and wholesale electricity wheeling. WRTA and other RTGs may even become vehicles for greater inter-utility coopertion and open access within Canada. The opportunities for participation in Canada/US transmission groups seem likely, but there are still issues to resolve - including the unknown shape of the US electric industry as it changes. As these uncertainties are worked through both Canadian and US companies may find new opportunities in cross border power sales.

  15. ,"Weekly Midwest Region Natural Gas Working Underground Storage (Billion Cubic Feet)"

    Energy Information Administration (EIA) (indexed site)

    Midwest Region Natural Gas Working Underground Storage (Billion Cubic Feet)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Weekly Midwest Region Natural Gas Working Underground Storage (Billion Cubic Feet)",1,"Weekly","11/11/2016" ,"Release Date:","11/17/2016" ,"Next Release

  16. Good Energies (Canada) | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Good Energies (Canada) Jump to: navigation, search Logo: Good Energies (Canada) Name: Good Energies (Canada) Address: 586 Argus Road, Suite 200 Place: Oakville, Canada Zip: L6J 3J3...

  17. Midwest Forensics Resource Center Project Summary June 2005

    SciTech Connect

    David Baldwin

    2005-06-01

    The mission of the MFRC Research and Development Program, is to provide technological advances in forensic science for the benefit of our regional partners as well as the forensic community at large. Key areas of forensic science need are identified through our interactions with our Midwest partners and our R&D advisory group, as well as through our participation in national meetings in forensic science. Under the sponsorship of the National Institute of Justice, the MFRC solicits proposals for the development of practical and useful technology, instrumentation, and methodology that address needs in areas related to forensic science and its application to operational crime laboratories. The MFRC facilitates proposal development by working to establish partnerships between researchers and our regional partners. The MFRC administers a peer-review of the proposals and then funds the selected projects at a cost of approximately $55,000 each, with a 12-month period of performance. The process for selection of these projects includes the following steps: (1) drafting of a call for proposals by MFRC staff, (2) review of the draft call by members of the R&D advisory committee, (3) review and approval of the call by NIJ, (4) issuance of the call to ISU, Ames Laboratory, regional partners, and research organizations, (5) receipt of proposals, (6) review of proposals by R&D advisory committee, (7) ranking and selection by MFRC staff using advisory committee reviews, with concurrence by NIJ, (8) notification of proposers, (9) receipt and review of progress reports by MFRC, (10) receipt and review of final reports by MFRC, R&D advisory committee, and NIJ. The decision to fund any specific project is based upon a peer-reviewed call-for-proposal system administered by the MFRC. The reviewers are crime laboratory specialists and scientists who are asked to rate the proposals on four criteria areas including: (1) relevance to the mission of the MFRC, (2) technical approach and

  18. US ENC MI Site Consumption

    Annual Energy Outlook

    ... Yes Yes No No 0% 20% 40% 60% 80% 100% US MI No Car CAR IS PARKED WITHIN 20 FT OF ELECTRICAL OUTLET More highlights from RECS on housing characteristics and energy-related ...

  19. "Table HC12.10 Home Appliances Usage Indicators by Midwest Census Region, 2005"

    Energy Information Administration (EIA) (indexed site)

    0 Home Appliances Usage Indicators by Midwest Census Region, 2005" " Million U.S. Housing Units" ,,"Midwest Census Region" ,"U.S. Housing Units (millions)" ,,,"Census Division" ,,"Total Midwest" "Home Appliances Usage Indicators",,,"East North Central","West North Central" "Total",111.1,25.6,17.7,7.9 "Cooking Appliances" "Frequency of Hot Meals Cooked" "3 or More Times A

  20. "Table HC12.12 Home Electronics Usage Indicators by Midwest Census Region, 2005"

    Energy Information Administration (EIA) (indexed site)

    2 Home Electronics Usage Indicators by Midwest Census Region, 2005" " Million U.S. Housing Units" ,,"Midwest Census Region" ,"U.S. Housing Units (millions)" ,,,"Census Division" ,,"Total Midwest" "Home Electronics Usage Indicators",,,"East North Central","West North Central" "Total",111.1,25.6,17.7,7.9 "Personal Computers" "Do Not Use a Personal Computer",35.5,8.1,5.6,2.5 "Use

  1. "Table HC12.5 Space Heating Usage Indicators by Midwest Census Region, 2005"

    Energy Information Administration (EIA) (indexed site)

    5 Space Heating Usage Indicators by Midwest Census Region, 2005" " Million U.S. Housing Units" ,,"Midwest Census Region" ,"U.S. Housing Units (millions)" ,,,"Census Division" ,,"Total Midwest" "Space Heating Usage Indicators",,,"East North Central","West North Central" "Total U.S. Housing Units",111.1,25.6,17.7,7.9 "Do Not Have Heating Equipment",1.2,"Q","Q","N"

  2. "Table HC12.7 Air-Conditioning Usage Indicators by Midwest Census Region, 2005"

    Energy Information Administration (EIA) (indexed site)

    7 Air-Conditioning Usage Indicators by Midwest Census Region, 2005" " Million U.S. Housing Units" ,,"Midwest Census Region" ,"U.S. Housing Units (millions)" ,,,"Census Division" ,,"Total Midwest" "Air Conditioning Usage Indicators",,,"East North Central","West North Central" "Total",111.1,25.6,17.7,7.9 "Do Not Have Cooling Equipment",17.8,2.1,1.8,0.3 "Have Cooling

  3. Real-time sub-<mi>>ngstrom...

    Office of Scientific and Technical Information (OSTI)

    Real-time sub-<mi>>ngstrom imaging of reversible and irreversible conformations in rhodium catalysts and graphene Kisielowski, Christian; Wang,...

  4. Midwest Has Potential to Store Hundreds of Years of CO2 Emissions |

    Energy.gov [DOE] (indexed site)

    Department of Energy Geologic capacity exists to permanently store hundreds of years of regional carbon dioxide (CO2) emissions in nine states stretching from Indiana to New Jersey, according to injection field tests conducted by the Midwest Regional Carbon Sequestration Partnership (MRCSP). MRCSP's just-released Phase II final report indicates the region has likely total storage of 245.5 billion metric tons of CO2, mostly in deep saline rock formations, a large capacity compared to present

  5. The contribution of future agricultural trends in the US Midwest to global climate change mitigation

    SciTech Connect

    Thomson, Allison M.; Kyle, G. Page; Zhang, Xuesong; Bandaru, Varaprasad; West, Tristram O.; Wise, Marshall A.; Izaurralde, Roberto C.; Calvin, Katherine V.

    2014-01-19

    Land use change is a complex response to changing environmental and socioeconomic systems. Historical drivers of land use change include changes in the natural resource availability of a region, changes in economic conditions for production of certain products and changing policies. Most recently, introduction of policy incentives for biofuel production have influenced land use change in the US Midwest, leading to concerns that bioenergy production systems may compete with food production and land conservation. Here we explore how land use may be impacted by future climate mitigation measures by nesting a high resolution agricultural model (EPIC – Environmental Policy Indicator Climate) for the US Midwest within a global integrated assessment model (GCAM – Global Change Assessment Model). This approach is designed to provide greater spatial resolution and detailed agricultural practice information by focusing on the climate mitigation potential of agriculture and land use in a specific region, while retaining the global economic context necessary to understand the far ranging effects of climate mitigation targets. We find that until the simulated carbon prices are very high, the US Midwest has a comparative advantage in producing traditional food and feed crops over bioenergy crops. Overall, the model responds to multiple pressures by adopting a mix of future responses. We also find that the GCAM model is capable of simulations at multiple spatial scales and agricultural technology resolution, which provides the capability to examine regional response to global policy and economic conditions in the context of climate mitigation.

  6. Mi GmbH | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Mi GmbH Jump to: navigation, search Name: Mi GmbH Place: Switzerland Zip: CH-6340 Sector: Solar Product: Baar-based manufacturer and distributor of fruit juices. The firm is also...

  7. Natural Resources Canada | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Canada Jump to: navigation, search Logo: Natural Resources Canada Name: Natural Resources Canada Address: 580 Booth Place: Ottawa, Ontario Zip: K1A 0E4 Number of Employees:...

  8. Tavrima Canada Inc | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Tavrima Canada builds a range of active carbon ultracapacitors used mainly in automotive applications. References: Tavrima Canada Inc.1 This article is a stub. You can...

  9. Application for presidential permit OE Docket No. PP-230-4 International Transmission Company: Supplemental Comments of the Midwest Independent Transmission System Operator

    Energy.gov [DOE]

    Supplemental comments of the Midwest Independent Transmission System Operaton on the application from International Transmission Company to construct, operate, and maintain electric transmission...

  10. miRNAs in brain development

    SciTech Connect

    Petri, Rebecca; Malmevik, Josephine; Fasching, Liana; Åkerblom, Malin; Jakobsson, Johan

    2014-02-01

    MicroRNAs (miRNAs) are small, non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. In the brain, a large number of miRNAs are expressed and there is a growing body of evidence demonstrating that miRNAs are essential for brain development and neuronal function. Conditional knockout studies of the core components in the miRNA biogenesis pathway, such as Dicer and DGCR8, have demonstrated a crucial role for miRNAs during the development of the central nervous system. Furthermore, mice deleted for specific miRNAs and miRNA-clusters demonstrate diverse functional roles for different miRNAs during the development of different brain structures. miRNAs have been proposed to regulate cellular functions such as differentiation, proliferation and fate-determination of neural progenitors. In this review we summarise the findings from recent studies that highlight the importance of miRNAs in brain development with a focus on the mouse model. We also discuss the technical limitations of current miRNA studies that still limit our understanding of this family of non-coding RNAs and propose the use of novel and refined technologies that are needed in order to fully determine the impact of specific miRNAs in brain development. - Highlights: • miRNAs are essential for brain development and neuronal function. • KO of Dicer is embryonically lethal. • Conditional Dicer KO results in defective proliferation or increased apoptosis. • KO of individual miRNAs or miRNA families is necessary to determine function.

  11. EA-297-B SESCO Enterprises Canada | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    -B SESCO Enterprises Canada EA-297-B SESCO Enterprises Canada Order authorizing SESCO Enterprises Canada to export electric energy to Canada. EA-297-B SESCO Enterprises Canada (3.59 MB) More Documents & Publications Application to Export Electric Energy OE Docket No. EA-297-B SESCO Enterprises Canada EA-297 SESCO Enterprises Canada EA-297-A SESCO Enterprises Canada Ltd.

  12. US-Canada Clean Energy Dialogue | Department of Energy

    Energy Saver

    US-Canada Clean Energy Dialogue US-Canada Clean Energy Dialogue US Canada Clean Energy Dialogue PDF icon US-Canada Clean Energy Dialogue More Documents & Publications U.S.-Canada...

  13. ,"Midwest Regions Natural Gas Underground Storage Net Withdrawals (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Regions Natural Gas Underground Storage Net Withdrawals (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Midwest Regions Natural Gas Underground Storage Net Withdrawals (MMcf)",1,"Monthly","8/2016" ,"Release Date:","10/31/2016" ,"Next Release

  14. Buildings*","Northeast",,"Midwest",,"South",,,"West"

    Energy Information Administration (EIA) (indexed site)

    B5. Census Region and Division, Floorspace for Non-Mall Buildings, 2003" ,"Total Floorspace (million square feet)" ,"All Buildings*","Northeast",,"Midwest",,"South",,,"West" ,,"New England","Middle Atlantic","East North Central","West North Central","South Atlantic","East South Central","West South Central","Mountain","Pacific" "All

  15. EA-297 SESCO Enterprises Canada | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    SESCO Enterprises Canada EA-297 SESCO Enterprises Canada Order authorizing SESCO Enterprises Canada to export electric energy to Canada. EA-297 SESCO Enterprises Canada (1.57 MB) More Documents & Publications EA-297-B SESCO Enterprises Canada EA-297-A SESCO Enterprises Canada Ltd.

  16. EA-297-A SESCO Enterprises Canada Ltd. | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    -A SESCO Enterprises Canada Ltd. EA-297-A SESCO Enterprises Canada Ltd. Order authorizing SESCO Enterprises Canada Ltd to export electric energy to Canada EA-297-A SESCO Enterprises Canada Ltd. (1.79 MB) More Documents & Publications EA-297 SESCO Enterprises Canada EA-297-B SESCO Enterprises Canada

  17. Vantage Point Venture Partners (Canada) | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Canada) Jump to: navigation, search Logo: Vantage Point Venture Partners (Canada) Name: Vantage Point Venture Partners (Canada) Address: 1200 McGill College, Suite 1240 Place:...

  18. DOE - Office of Legacy Management -- Detrex Corp - MI 10

    Office of Legacy Management (LM)

    Detroit , Michigan MI.10-1 Evaluation Year: 1987 MI.10-2 Site Operations: Conducted experimental runs relative to picklingdegreasing of one handful of uranium turnings MI.10-1...

  19. DOE - Office of Legacy Management -- Adrian - MI 01

    Office of Legacy Management (LM)

    Adrian - MI 01 FUSRAP Considered Sites Adrian, MI Alternate Name(s): Bridgeport Brass Co. Special Metals Extrusion Plant Bridgeport Brass Company General Motors General Motors Company, Adrian MI.01-1 Location: 1450 East Beecher Street, Adrian, Michigan MI.01-3 Historical Operations: Performed uranium extrusion research and development and metal fabrication work for the AEC using uranium, thorium, and plutonium. MI.01-2 Eligibility Determination: Eligible MI.01-1 Radiological Survey(s):

  20. Midwest Region Natural Gas in Underground Storage (Base Gas) (Million Cubic

    Energy Information Administration (EIA) (indexed site)

    Feet) Base Gas) (Million Cubic Feet) Midwest Region Natural Gas in Underground Storage (Base Gas) (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2013 1,503,197 1,503,193 1,502,629 1,501,810 1,503,236 1,504,117 1,504,116 1,504,114 1,504,506 1,502,817 1,502,848 1,503,480 2014 1,505,645 1,504,979 1,497,798 1,502,556 1,498,128 1,498,610 1,498,610 1,498,610 1,498,887 1,496,791 1,496,848 1,497,021 2015 1,497,256 1,496,957 1,496,400 1,495,858 1,495,743 1,496,917 1,496,915

  1. Midwest Region Natural Gas in Underground Storage - Change in Working Gas

    Energy Information Administration (EIA) (indexed site)

    from Same Month Previous Year (Million Cubic Feet) - Change in Working Gas from Same Month Previous Year (Million Cubic Feet) Midwest Region Natural Gas in Underground Storage - Change in Working Gas from Same Month Previous Year (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2013 -63,664 -102,296 -211,632 -235,463 -214,379 -166,660 -123,165 -100,408 -77,814 -65,919 -81,637 -181,602 2014 -243,074 -255,871 -209,941 -189,692 -156,914 -124,375 -83,035 -47,387 -33,755

  2. Practices and Processes of Leading High Performance Home Builders in the Upper Midwest

    SciTech Connect

    Von Thoma, Ed; Ojzcyk, Cindy

    2012-12-01

    The NorthernSTAR Building America Partnership team proposed this study to gain insight into the business, sales, and construction processes of successful high performance builders. The knowledge gained by understanding the high performance strategies used by individual builders, as well as the process each followed to move from traditional builder to high performance builder, will be beneficial in proposing more in-depth research to yield specific action items to assist the industry at large transform to high performance new home construction. This investigation identified the best practices of three successful high performance builders in the upper Midwest. In-depth field analysis of the performance levels of their homes, their business models, and their strategies for market acceptance were explored.

  3. DOE - Office of Legacy Management -- Oliver Corp - MI 11

    Office of Legacy Management (LM)

    OLIVER CORP. (MI.11 ) Eliminated from further consideration under FUSRAP - Referred to NRC Designated Name: Not Designated Alternate Name: Behnke Warehousing Incorporated MI.11-1...

  4. Phoenix Canada Oil Company | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Canada Oil Company Place: Toronto, Ontario, Canada Zip: M5J 1S9 Sector: Hydro, Hydrogen, Solar Product: Oil and gas exploration company, with a US division, Phoenix...

  5. CANADA-UNITED STATES REGULATORY COOPERATION COUNCIL

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    CANADA-UNITED STATES REGULATORY COOPERATION COUNCIL Webinar: Proposed Approach for Energy Efficiency Standards January 12, 2015 Natural Resources Ressources naturelles Canada Canada Key Contacts in U.S. and Canada NRCan * Debbie Scharf, Director of Equipment Division * Katherine Delves, Chief of Standards Development * Jamie Hulan, Team leader for Standards Development * Andrés Drew, RCC lead DOE * John Cymbalsky, Program Manager for Appliance Standards * Ashley Armstrong, Supervisory

  6. Fuel Additives: Canada bans MMT

    SciTech Connect

    Sissell, K.

    1997-04-16

    The Canadian Senate voted late last week to ban use of the manganese-based fuel additive MMT, produced only in the US by Ethyl. MMT, which has been sold in Canada for the past 20 years and accounts for about half of Ethyl`s Canadian sales, has been criticized by environmentalists, who have raised public health concerns, and automakers, who say it harms emission control systems. {open_quotes}Canada`s vote is a great victory for public health and the environment,{close_quotes} says Environmental Defense Fund executive director Fred Krupp. {open_quotes}The US should move swiftly to follow suit and suspend sales of MMT until adequate toxicity testing on the additive is completed.{close_quotes} EPA had refused to approve MMT for sale because of health concerns but was compelled to do so by a December 1995 court ruling. Ethyl asserts the ban violates Canada`s obligations under Nafta and says it will file a damage claim with the Nafta arbitration panel.

  7. Canada | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    Canada NNSA Hosts International Nuclear Forensics Workshop with Participants from Eight Countries WASHINGTON, D.C. - During May 11-22, the National Nuclear Security Administration's (NNSA) Nuclear Smuggling Detection and Deterrence program held a hands-on nuclear forensics course at the Pacific Northwest National Laboratory (PNNL) in Richland, Washington. The "International Training Course on

  8. EA-326 Citigroup Energy Canada ULC | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Citigroup Energy Canada ULC EA-326 Citigroup Energy Canada ULC Order authorizing Citigroup Energy Canada ULC to export electric energy to Canada EA-326 Citigroup Energy Canada ULC (2.98 MB) More Documents & Publications EA-326-A Citigroup Energy Canada ULC Application to Export Electric Energy OE Docket No. EA-326-A Citigroup Energy

  9. EA-342 Royal Bank of Canada | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Royal Bank of Canada EA-342 Royal Bank of Canada Order authorizing Royal Bank of Canada to export electric energy to Canada EA-342 Royal Bank of Canada (3.17 MB) More Documents & Publications EA-342-A Royal Bank of Canada EA-330 The Royal Bank of Scotland plc EA-330-A The Royal Bank of Scotland plc

  10. Sault St Marie, MI Natural Gas Pipeline Exports to Canada (Million Cubic

    Energy Information Administration (EIA) (indexed site)

    Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's NA 2000's NA NA NA 605 6,666 5,537 5,070 4,389 3,122 2,044 2010's 4,011 9,555 24,913 16,288 4,457 6,18

  11. St. Clair, MI Natural Gas Pipeline Exports to Canada (Million Cubic Feet)

    Energy Information Administration (EIA) (indexed site)

    Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 19,315 20,080 11,397 11,258 2000's 29,654 122,293 164,084 238,444 317,797 286,804 286,582 418,765 492,235 612,369 2010's 650,590 781,058 754,494 582,509 478,645 435,74

  12. Marysville, MI Natural Gas Pipeline Exports to Canada (Million Cubic Feet)

    Energy Information Administration (EIA) (indexed site)

    Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 638 5,286 3,377 691 2000's 5,320 3,651 NA 811 4,455 5,222 3,483 9,158 8,756 14,925 2010's 22,198 41,964 42,866 35,273 24,583 7,20

  13. Marysville, MI Natural Gas Pipeline Exports to Canada (Dollars per Thousand

    Energy Information Administration (EIA) (indexed site)

    Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 2.97 2.36 2.17 2.47 2000's 2.91 3.92 NA 5.06 6.83 7.92 7.36 7.77 7.48 4.85 2010's 4.87 4.48 3.18 3.98 5.45 3.55

  14. Marysville, MI Natural Gas Pipeline Exports to Canada (Dollars per Thousand

    Energy Information Administration (EIA) (indexed site)

    Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 4.71 4.55 4.42 4.87 4.86 4.93 4.77 4.76 4.38 4.25 3.90 3.76 2012 3.32 2.95 2.71 2.49 2.42 2.74 3.14 3.24 3.03 3.42 3.93 4.03 2013 3.69 3.62 3.91 4.48 4.58 4.35 3.93 3.65 3.88 3.85 3.84 4.44 2014 5.50 8.11 11.25 4.99 4.79 4.90 4.31 4.06 4.08 3.93 4.63 3.77 2015 3.15 4.22 3.68 2.87 2.87 2.96 3.05 3.10 2.67 2.27 2.09 2016 2.45 2.05 1.84 2.08 2.04 2.51 2.60 2.78

  15. Price of Port Huron, MI Liquefied Natural Gas Exports to Canada...

    Annual Energy Outlook

    Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2013 9.48 2014 10.66 10.66 9.74 10.09 9.74 9.85 9.85 9.85 10.86 10.99 2015 10.25 10.00 9.63 9.63 8.77...

  16. Price of Port Huron, MI Liquefied Natural Gas Exports to Canada...

    Energy Information Administration (EIA) (indexed site)

    Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 2010's -- 9.48 10.16...

  17. Sault St Marie, MI Natural Gas Pipeline Exports (Price) Canada (Dollars per

    Energy Information Administration (EIA) (indexed site)

    Thousand Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's NA 2000's NA NA NA 4.94 6.38 8.13 8.11 7.13 8.75 5.04 2010's 5.27 4.23 3.20 4.04 6.01 3.47

  18. Sault St Marie, MI Natural Gas Pipeline Exports (Price) Canada (Dollars per

    Energy Information Administration (EIA) (indexed site)

    Thousand Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 4.73 4.36 4.18 4.50 4.50 4.60 4.76 4.53 4.13 4.00 3.96 3.76 2012 3.32 3.11 2.69 2.41 2.48 2.70 3.14 3.24 3.10 3.57 4.11 3.92 2013 3.74 3.68 4.20 4.46 4.51 4.36 4.09 3.98 4.05 3.96 3.83 4.49 2014 5.47 11.53 10.62 5.16 5.18 5.06 4.87 5.09 4.25 2015 3.59 4.45 3.53 2.87 3.08 2.85 2016 2.53 2.46 1.96 1.96

  19. Sault St Marie, MI Natural Gas Pipeline Exports to Canada (Million Cubic

    Energy Information Administration (EIA) (indexed site)

    Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 453 278 308 68 87 1,115 1,010 1,125 1,019 1,026 1,107 1,960 2012 2,630 2,246 2,518 2,102 1,445 1,633 1,910 1,763 1,489 1,996 2,591 2,590 2013 2,802 2,569 2,054 1,531 1,171 935 1,231 849 911 896 705 542 2014 572 461 333 632 74 23 119 1,114 1,131 2015 1,322 1,189 1,120 1,074 690 793 2016 48 112 8

  20. St. Clair, MI Natural Gas Pipeline Exports to Canada (Million Cubic Feet)

    Energy Information Administration (EIA) (indexed site)

    Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 74,025 68,809 83,796 62,851 68,731 59,044 56,015 56,094 66,775 52,380 65,815 66,723 2012 62,390 62,442 72,035 61,364 66,456 54,973 52,240 66,101 67,443 61,205 62,762 65,084 2013 56,510 52,567 58,126 43,917 56,075 54,114 42,609 45,524 47,795 43,767 34,054 45,093 2014 52,731 57,817 68,448 44,792 24,659 31,385 28,556 21,997 28,757 27,488 40,820 51,194 2015 50,905 58,264 66,483 34,226 25,282 24,830 20,051 22,111 37,442 34,246 34,326 27,579

  1. Detroit, MI Natural Gas Pipeline Exports to Canada (Dollars per Thousand

    Energy Information Administration (EIA) (indexed site)

    Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 2.36 2.55 2.26 2.30 2000's 3.74 4.57 3.03 5.47 6.47 8.12 7.61 6.88 8.37 4.01 2010's 4.69 4.26 3.10 4.04 5.36 2.91

  2. Detroit, MI Natural Gas Pipeline Exports to Canada (Dollars per Thousand

    Energy Information Administration (EIA) (indexed site)

    Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 4.72 4.58 4.22 4.51 4.66 4.73 4.55 4.45 4.19 3.92 3.79 3.60 2012 3.14 2.95 2.61 2.33 2.50 2.62 3.08 3.12 2.99 3.41 4.13 3.90 2013 4.04 3.67 3.96 4.42 4.42 4.26 4.02 3.84 3.90 3.89 3.79 4.34 2014 5.67 10.21 7.89 4.89 4.93 4.86 4.44 4.06 4.14 4.11 4.20 4.16 2015 3.38 3.80 3.19 2.77 2.78 2.94 2.97 3.07 2.91 2.71 2.22 2.24 2016 2.50 2.25 1.86 1.92 1.91 2.31 2.96 2.85

  3. Detroit, MI Natural Gas Pipeline Exports to Canada (Million Cubic Feet)

    Energy Information Administration (EIA) (indexed site)

    Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 3,465 2,693 3,676 3,988 3,357 3,437 765 3,916 4,318 4,473 4,851 4,752 2012 5,562 5,372 5,253 3,745 3,354 2,811 2,935 3,822 4,015 4,113 4,636 4,728 2013 4,791 4,331 4,801 3,571 4,430 3,769 3,933 4,131 3,885 2,862 3,886 4,945 2014 4,042 4,259 4,171 3,540 3,852 4,008 3,643 3,461 3,414 4,013 3,800 4,779 2015 3,753 2,420 4,176 2,416 2,035 1,911 2,624 2,674 4,755 4,944 3,048 2,773 2016 2,881 2,701 3,427 1,402 1,301 2,806 2,190 2,324

  4. Detroit, MI Natural Gas Pipeline Imports From Canada (Dollars per Thousand

    Energy Information Administration (EIA) (indexed site)

    Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 2.75 2.51 2.43 2.51 2000's 3.82 9.34 3.56 5.96 6.27 -- -- 8.28 6.58 4.53 2010's 8.37 5.17 -- 4.44 5.26 --

  5. Detroit, MI Natural Gas Pipeline Imports From Canada (Dollars per Thousand

    Energy Information Administration (EIA) (indexed site)

    Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 4.95 5.33 2013 3.80 4.50 4.09 4.63 2014 5.26

  6. Detroit, MI Natural Gas Pipeline Imports From Canada (Million Cubic Feet)

    Energy Information Administration (EIA) (indexed site)

    Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 8 11 2013 16 140 24 10 2014 188

  7. The NuMI neutrino beam

    DOE PAGES [OSTI]

    Adamson, P.; Anderson, K.; Andrews, M.; Andrews, R.; Anghel, I.; Augustine, D.; Aurisano, A.; Avvakumov, S.; Ayres, D. S.; Baller, B.; et al

    2015-10-20

    Our paper describes the hardware and operations of the Neutrinos at the Main Injector (NuMI) beam at Fermilab. It elaborates on the design considerations for the beam as a whole and for individual elements. The most important part of our design details pertaining to individual components is described. Beam monitoring systems and procedures, including the tuning and alignment of the beam and NuMI long-term performance, are also discussed.

  8. The NuMI Neutrino Beam

    SciTech Connect

    Adamson, P.; Anderson, K.; Andrews, M.; Andrews, R.; Anghel, I.; Augustine, D.; Aurisano, A.; Avvakumov, S.; Ayres, D. S.; Baller, B.; Barish, B.; Barr, G.; Barrett, W. L.; Berstein, R. H.; Biggs, J.; Bishai, M.; Blake, A.; Bocean, V.; Bock, G. J.; Boehnlein, D. J.; Bogert, D.; Bourkland, K.; Cao, S. V.; Castromonte, C. M.; Childress, S.; Choudhary, B. C.; Coelho, J. A.B.; Cobb, J. H.; Corwin, L.; Crane, D.; Cravens, J. P.; Cronin-Hennessy, D.; Ducar, R. J.; De Jong, J. K.; Devan, A. V.; Devenish, N. E.; Diwan, M. V.; Erwin, A. R.; Escobar, C. O.; Evans, J. J.; Falk, E.; Feldman, G. J.; Fields, T. H.; Ford, R.; Frohne, M. V.; Gallahger, H. R.; Garkusha, V.; Gomes, R. A.; Goodman, M. C.; Gouffon, P.; Graf, N.; Gran, R.; Grossman, N.; Grzelak, K.; Habig, A.; Hahn, S. R.; Harding, D.; Harris, D.; Harris, P. G.; Hartnell, J.; Hatcher, R.; Hays, S.; Heller, K.; Holin, A.; Huang, J.; Hylen, J.; Ibrahim, A.; Indurthy, D.; Irwin, G. M.; Isvan, Z.; Jaffe, D. E.; James, C.; Jensen, D.; Johnstone, J.; Kafka, T.; Kasahara, S. M.S.; Koizumi, G.; Kopp, S.; Kordosky, M.; Kreymer, A.; Lang, K.; Laughton, C.; Lefeuvre, G.; Ling, J.; Litchfield, P. J.; Loiacono, L.; Lucas, P.; Mann, W. A.; Marchionni, A.; Marshak, M. L.; Mayer, N.; McGivern, C.; Medeiros, M. M.; Mehdiyev, R.; Meier, J. R.; Messier, M. D.; Michael, D. G.; Milburn, R. H.; Miller, J. L.; Miller, W. H.; Mishra, S. R.; Sher, S. Moed; Moore, C. D.; Morfin, J.; Mualem, L.; Mufson, S.; Murgia, S.; Murtagh, M.; Musser, J.; Naples, D.; Nelson, J. K.; Newman, H. B.; Nichol, R. J.; Nowak, J. A.; O'connor, J.; Oliver, W. P.; Olsen, M.; Orchanian, M.; Osprey, S.; Pahlka, R. B.; Paley, J.; Para, A.; Patterson, R. B.; Patzak, T.; Pavlovic, Z.; Pawloski, G.; Perch, A.; Peterson, E. A.; Petyt, D. A.; Pfutzner, M. M.; Phan-Budd, S.; Plunkett, R. K.; Poonthottathil, N.; Prieto, P.; Pushka, D.; Qiu, X.; Radovic, A.; Rameika, R. A.; Ratchford, J.; Rebel, B.; Reilly, R.; Rosenfeld, C.; Rubin, H. A.; Ruddick, K.; Sanchez, M. C.; Saoulidou, N.; Sauer, L.; Schneps, J.; Schoo, D.; Schreckenberger, A.; Schreiner, P.; Shanahan, P.; Sharma, R.; Smart, W.; Smith, C.; Sousa, A.; Stefanik, A.; Tagg, N.; Talaga, R. L.; Tassotto, G.; Thomas, J.; Thompson, J.; Thomson, M. A.; Tian, X.; Timmons, A.; Tinsley, D.; Tognini, S. C.; Toner, R.; Torretta, D.; Trostin, I.; Tzanakos, G.; Urheim, J.; Vahle, P.; Vaziri, K.; Villegas, E.; Viren, B.; Vogel, G.; Webber, R. C.; Weber, A.; Webb, R. C.; Wehmann, A.; White, C.; Whitehead, L.; Whitehead, L. H.; Wojcicki, S. G.; Wong-Squires, M. L.; Yang, T.; Yumiceva, F. X.; Zarucheisky, V.; Zwaska, R.

    2015-10-20

    Our paper describes the hardware and operations of the Neutrinos at the Main Injector (NuMI) beam at Fermilab. It elaborates on the design considerations for the beam as a whole and for individual elements. The most important part of our design details pertaining to individual components is described. Beam monitoring systems and procedures, including the tuning and alignment of the beam and NuMI long-term performance, are also discussed.

  9. Practices and Processes of Leading High Performance Home Builders in the Upper Midwest

    SciTech Connect

    Von Thoma, E.; Ojczyk, C.

    2012-12-01

    The NorthernSTAR Building America Partnership team proposed this study to gain insight into the business, sales, and construction processes of successful high performance builders. The knowledge gained by understanding the high performance strategies used by individual builders, as well as the process each followed to move from traditional builder to high performance builder, will be beneficial in proposing more in-depth research to yield specific action items to assist the industry at large transform to high performance new home construction. This investigation identified the best practices of three successful high performance builders in the upper Midwest. In-depth field analysis of the performance levels of their homes, their business models, and their strategies for market acceptance were explored. All three builders commonly seek ENERGY STAR certification on their homes and implement strategies that would allow them to meet the requirements for the Building America Builders Challenge program. Their desire for continuous improvement, willingness to seek outside assistance, and ambition to be leaders in their field are common themes. Problem solving to overcome challenges was accepted as part of doing business. It was concluded that crossing the gap from code-based building to high performance based building was a natural evolution for these leading builders.

  10. Rural Living Canada Website | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Equivalent URI: cleanenergysolutions.orgcontentrural-living-canada-website Language: English Policies: "Deployment Programs,Regulations" is not in the list of possible...

  11. "Changing Natural Gas Pipeline Throughputs in Canada"

    Annual Energy Outlook

    Changing Natural Gas Pipeline Throughputs in Canada" Presented at 2015 EIA Energy Conference June 15, 2015 Margaret Skwara, National Energy Board Abha Bhargava, National Energy ...

  12. Canada-US Clean Energy Dialogue:

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    First Report to the Prime Minister of Canada and the President of the United States of America September 16, 2009 The Honorable Steven Chu Secretary of Energy United States of America The Honourable Jim Prentice Minister of the Environment Canada U.S.-Canada Clean Energy Dialogue First Report to the Prime Minister of Canada and the President of the United States of America President Obama and Prime Minister Harper: When you met in Ottawa in February 2009, you set out an ambitious plan for our

  13. Canada: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    and promoting the use of renewable energy. 1 Recent News Development of flexible solar panel External Links EIA Report: Canada Energy Data, Statistics, and Alaysis EIA:...

  14. EA-253-A Coral Canada US Inc | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    3-A Coral Canada US Inc EA-253-A Coral Canada US Inc Order authorizing Coral Canada US Inc to export electric energy to Canada. EA-253-A Coral Canada US Inc (1.63 MB) More Documents & Publications EA-213-A Coral Power, LLC EA-286-A Avista Energy Inc EA-286 Avista Energy

  15. EA-356 J.P. Morgan Commodities Canada Corporation | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    J.P. Morgan Commodities Canada Corporation EA-356 J.P. Morgan Commodities Canada Corporation Order authorizing J.P. Morgan Commodities Canada Corporation to export electric energy ...

  16. United States, Canada Announce Next Phase of U.S.-Canada Clean Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Dialogue | Department of Energy Announce Next Phase of U.S.-Canada Clean Energy Dialogue United States, Canada Announce Next Phase of U.S.-Canada Clean Energy Dialogue June 21, 2012 - 2:15pm Addthis News Media Contact (202) 586-4940 WASHINGTON -- Today, the U.S. Department of Energy (DOE) and Environment Canada released the U.S.-Canada Clean Energy Dialogue (CED) Action Plan II, outlining the next phase of activities the two countries will undertake to jointly advance clean energy

  17. DOE - Office of Legacy Management -- Naval Ordnance Plant - MI...

    Office of Legacy Management (LM)

    Eliminated from further consideration under FUSRAP - Referred to DoD for action Designated ... MI.0-03-1 Site Disposition: Eliminated - No Authority - Referred to DoD MI.0-03-1 ...

  18. miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor

    SciTech Connect

    Park, Jong-Kook; Henry, Jon C.; Jiang, Jinmai; Esau, Christine; Gusev, Yuriy; Lerner, Megan R.; Postier, Russell G.; Brackett, Daniel J.; Schmittgen, Thomas D.

    2011-03-25

    Research highlights: {yields} The expression of miR-132 and miR-212 are significantly increased in pancreatic cancer. {yields} miR-132 and miR-212 target the tumor suppressor pRb, resulting in enhanced proliferation. {yields} miR-132 and miR-212 expression is increased by a {beta}2 adrenergic receptor agonist, suggesting a novel mechanism for pancreatic cancer progression. -- Abstract: Numerous microRNAs (miRNAs) are reported as differentially expressed in cancer, however the consequence of miRNA deregulation in cancer is unknown for many miRNAs. We report that two miRNAs located on chromosome 17p13, miR-132 and miR-212, are over-expressed in pancreatic adenocarcinoma (PDAC) tissues. Both miRNAs are predicted to target the retinoblastoma tumor suppressor, Rb1. Validation of this interaction was confirmed by luciferase reporter assay and western blot in a pancreatic cancer cell line transfected with pre-miR-212 and pre-miR-132 oligos. Cell proliferation was enhanced in Panc-1 cells transfected with pre-miR-132/-212 oligos. Conversely, antisense oligos to miR-132/-212 reduced cell proliferation and caused a G{sub 2}/M cell cycle arrest. The mRNA of a number of E2F transcriptional targets were increased in cells over expressing miR-132/-212. Exposing Panc-1 cells to the {beta}2 adrenergic receptor agonist, terbutaline, increased the miR-132 and miR-212 expression by 2- to 4-fold. We report that over-expression of miR-132 and miR-212 result in reduced pRb protein in pancreatic cancer cells and that the increase in cell proliferation from over-expression of these miRNAs is likely due to increased expression of several E2F target genes. The {beta}2 adrenergic pathway may play an important role in this novel mechanism.

  19. Photovoltaic Potential and Insolation Maps (Canada) | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    Insolation Maps (Canada) Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Photovoltaic Potential and Insolation Maps (Canada) Focus Area: Renewable Energy Topics:...

  20. Canada to Support NNSA Effort to Fight Nuclear Terrorism | National...

    National Nuclear Security Administration (NNSA)

    We appreciate Canada's generous support and contribution." Canada will join two NNSA-led efforts to fight the proliferation of nuclear and radiological material that could be used ...

  1. Price of Compressed Houlton ME Natural Gas Imports from Canada...

    Energy Information Administration (EIA) (indexed site)

    Houlton ME Natural Gas Imports from Canada (Dollars per Thousand Cubic Feet) Price of Compressed Houlton ME Natural Gas Imports from Canada (Dollars per Thousand Cubic Feet) Year ...

  2. Ontario Renewable Energy Atlas (Canada) | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Renewable Energy Atlas (Canada) Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Ontario Renewable Energy Atlas (Canada) Focus Area: Renewable Energy Topics: Potentials &...

  3. Sweetgrass, MT Liquefied Natural Gas Pipeline Exports to Canada...

    Energy Information Administration (EIA) (indexed site)

    Liquefied Natural Gas Pipeline Exports to Canada (Million Cubic Feet) Sweetgrass, MT Liquefied Natural Gas Pipeline Exports to Canada (Million Cubic Feet) Year Jan Feb Mar Apr May ...

  4. Canada-United States Regulatory Cooperation Council Webinar:...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Canada-United States Regulatory Cooperation Council Webinar: Proposed Approach for Energy Efficiency Standards Canada-United States Regulatory Cooperation Council Webinar: Proposed ...

  5. Natural Resources Canada and DOE Announce Enhanced Energy Collaboratio...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Natural Resources Canada and DOE Announce Enhanced Energy Collaboration Natural Resources Canada and DOE Announce Enhanced Energy Collaboration September 19, 2014 - 3:32pm Addthis ...

  6. CANADA-UNITED STATES REGULATORY COOPERATION COUNCIL Webinar:...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    CANADA-UNITED STATES REGULATORY COOPERATION COUNCIL Webinar: Work Plan Development - 201617; April 12, 2016 CANADA-UNITED STATES REGULATORY COOPERATION COUNCIL Webinar: Work Plan ...

  7. Price of Portal, ND Liquefied Natural Gas Exports to Canada ...

    Annual Energy Outlook

    Portal, ND Liquefied Natural Gas Exports to Canada (Dollars per Thousand Cubic Feet) Price of Portal, ND Liquefied Natural Gas Exports to Canada (Dollars per Thousand Cubic Feet)...

  8. Demonstrating Electric Vehicles in Canada | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Demonstrating Electric Vehicles in Canada Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Demonstrating Electric Vehicles in Canada AgencyCompany Organization: Natural...

  9. Price of Crosby, ND Liquefied Natural Gas Exports to Canada ...

    Annual Energy Outlook

    Crosby, ND Liquefied Natural Gas Exports to Canada (Dollars per Thousand Cubic Feet) Price of Crosby, ND Liquefied Natural Gas Exports to Canada (Dollars per Thousand Cubic Feet)...

  10. Category:Canada Provinces and Territories | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Canada Provinces and Territories Jump to: navigation, search Canadian Provinces and Territories Pages in category "Canada Provinces and Territories" The following 10 pages are in...

  11. Zongshen PEM Canada Chongqing Hydrogen Energy Ltd | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    Zongshen PEM Canada Chongqing Hydrogen Energy Ltd Jump to: navigation, search Name: Zongshen PEM (Canada) Chongqing Hydrogen Energy Ltd Place: Chongqing Municipality, China...

  12. Fact #691: September 5, 2011 Mexico Surpassed Canada in Vehicle...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    1: September 5, 2011 Mexico Surpassed Canada in Vehicle Production Fact 691: September 5, 2011 Mexico Surpassed Canada in Vehicle Production In 2008, Mexico produced more vehicles ...

  13. “Nodal Gap” induced by the incommensurate diagonal spin density modulation in underdoped high- <mi>Tmi>c> superconductors

    SciTech Connect

    Zhou, Tao; Gao, Yi; Zhu, Jian -Xin

    2015-03-07

    Recently it was revealed that the whole Fermi surface is fully gapped for several families of underdoped cuprates. The existence of the finite energy gap along the <mi>d>-wave nodal lines (nodal gap) contrasts the common understanding of the <mi>d>-wave pairing symmetry, which challenges the present theories for the high-<mi>Tmi><mi>c>superconductors. Here we propose that the incommensurate diagonal spin-density-wave order can account for the above experimental observation. The Fermi surface and the local density of states are also studied. Our results are in good agreement with many important experiments in high-<mi>Tmi><mi>c>superconductors.

  14. Characterization of function and regulation of miR-24-1 and miR-31

    SciTech Connect

    Sun Fenyong; Wang Jiayi; Pan Qiuhui; Yu Yongchun; Zhang Yue; Wan Yang; Wang Ju; Li Xiaoyan; Hong An

    2009-03-13

    To date, numerous microRNAs (miRNAs) have been discovered. However, the function of these miRNAs is largely unknown. While our knowledge of miRNA post-transcriptional processing has greatly expanded in recent years, we have a limited understanding of the regulation and transcription of miRNA genes. In this study, we characterized two BMP-2 upregulated miRNAs, miR-24-1 and miR-31, in mesenchymal stem cells and showed their opposing function in controlling cellular proliferation, and adipogenesis. Furthermore, we are the first to identify and characterize mouse intronic miR-23b{approx}27b{approx}24-1 and intergenic miR-31 genes. Moreover, we found that pri-miR-23b, pri-miR-27b, and pri-miR-24-1 are transcribed independently and their expression profiles are unique when cells are treated with BMP-2, even though they are located closely together.

  15. The potential impacts of a competitive wholesale market in the midwest: A preliminary examination of centralized dispatch

    SciTech Connect

    Lesieutre, Bernard C.; Bartholomew, Emily; Eto, Joseph H.; Hale, Douglas; Luong, Thanh

    2004-07-01

    In March 2005, the Midwest Independent System Operator (MISO) will begin operating the first-ever wholesale market for electricity in the central and upper Midwestern portion of the United States. Region-wide, centralized, security-constrained, bid-based dispatch will replace the current system of decentralized dispatch by individual utilities and control areas. This report focuses on how the operation of generators may change under centralized dispatch. We analyze a stylized example of these changes by comparing a base case dispatch based on a ''snapshot'' taken from MISO's state estimator for an actual, historical dispatch (4 p.m., July 7, 2003) to a hypothetical, centralized dispatch that seeks to minimize the total system cost of production, using estimated cost data collected by the EIA. Based on these changes in dispatch, we calculate locational marginal prices, which in turn reveals the location of congestion within MISO's footprint, as well as the distribution of congestion revenues. We also consider two sensitivity scenarios that examine (1) the effect of changes in MISO membership (2003 vs. 2004 membership lists), and (2) different load and electrical data, based on a snapshot from a different date and time (1 p.m., Feb. 18, 2004). Although our analysis offers important insights into how the MISO market could operate when it opens, we do not address the question of the total benefits or costs of creating a wholesale market in the Midwest.

  16. EA-326-A Citigroup Energy Canada ULC | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    -A Citigroup Energy Canada ULC EA-326-A Citigroup Energy Canada ULC Order authorizing Citigroup to export electric energy to Canada. EA-326-A CECU.pdf (854.79 KB) More Documents & Publications Application to Export Electric Energy OE Docket No. EA-326-A Citigroup Energy Canada ULC EA-326 Citigroup Energy

  17. EA-346 Credit Suisse Energy LLC - Canada | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Canada EA-346 Credit Suisse Energy LLC - Canada Order authorizing Credit Suisse Energy LLC to export electric energy to Canada EA-346 Credit Suisse Energy LLC (2.93 MB) More Documents & Publications EA-346 Credit Suisse Energy LLC - Mexico EA-344 Twin Cities Power-Canada, LLC EA-354 Endure Energy, L.L.C.

  18. Energy Management Programs at 3M Canada

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    1 July 2014 . All Rights Reserved. 3M Energy Management at 3M Canada OVERVIEW An Introduction to 3M 3M Sustainability Energy Management Initiatives Results Insight 1 July 2014 . ...

  19. Magnetocrystalline anisotropy in <mi>UMn>2<mi>Ge>2 and related Mn-based actinide ferromagnets

    SciTech Connect

    Parker, David S.; Ghimire, Nirmal; Singleton, John; Thompson, J. D.; Bauer, Eric D.; Baumbach, Ryan; Mandrus, David; Li, Ling; Singh, David J.

    2015-05-04

    We present magnetization isotherms in pulsed magnetic fields up to 62 Tesla, supported by first principles calculations, demonstrating a huge uniaxial magnetocrystalline anisotropy energy - approximately 20 MJ/m3 - in <mi>UMn>2<mi>Ge>2. This large anisotropy results from the extremely strong spin-orbit coupling affecting the uranium 5 f electrons, which in the calculations exhibit a substantial orbital moment exceeding 2 μB. Finally, we also find from theoretical calculations that a number of isostructural Mn-actinide compounds are expected to have similarly large anisotropy.

  20. DOE - Office of Legacy Management -- Star Cutter Corp - MI 15

    Office of Legacy Management (LM)

    Eliminated - Potential for contamination considered remote based on limited scope and quantity of materials handled MI.15-2 Radioactive Materials Handled: Yes Primary ...

  1. MINOS Experiment and NuMI Beam Home Page

    U.S. Department of Energy (DOE) - all webpages

    NuMI-MINOS Neutrino Logo NuMI Beamline and MINOS Experiment Neutrino Logo The MINOS Experiment and NuMI Beamline Fermilab Logo MINOS Experiment Links ◊ MINOS for the Public ◊ Scientific Results ◊ MINOS at Work ◊ NuMI at Work ◊ MINOS+ Experiment Fermilab Neutrino Links ◊ Neutrino FAQ ◊ MINOS Underground Areas at Fermilab ◊ PPD Intensity Frontier Dept Back to - - - ◊ Fermilab at Work ◊ Fermilab Home the MINOS Far Detector in the Soudan Mine MINOS collaborators assembling the

  2. ,"U.S. Liquefied Natural Gas Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Liquefied Natural Gas Imports From Canada (MMcf)" "Sourcekey","NGMEPG0NUS-NCAIMLMMCF" "Date","U.S. Liquefied Natural Gas Imports From Canada (MMcf)" 41090,0 41455,555 ...

  3. Compressed Houlton, ME Natural Gas Imports from Canada (Million...

    Energy Information Administration (EIA) (indexed site)

    Houlton, ME Natural Gas Imports from Canada (Million Cubic Feet) Compressed Houlton, ME Natural Gas Imports from Canada (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug ...

  4. Price of Sumas, WA Liquefied Natural Gas Imports from Canada...

    Annual Energy Outlook

    from Canada (Dollars per Thousand Cubic Feet) Price of Sumas, WA Liquefied Natural Gas Imports from Canada (Dollars per Thousand Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug...

  5. Crosby, ND Liquefied Natural Gas Pipeline Exports to Canada ...

    Annual Energy Outlook

    Pipeline Exports to Canada (Million Cubic Feet) Crosby, ND Liquefied Natural Gas Pipeline Exports to Canada (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov ...

  6. Buffalo, NY Liquefied Natural Gas Exports to Canada (Million...

    Energy Information Administration (EIA) (indexed site)

    to Canada (Million Cubic Feet) Buffalo, NY Liquefied Natural Gas Exports to Canada (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2015 1 1 1 1 - No ...

  7. Portal, ND Liquefied Natural Gas Exports to Canada (Million Cubic...

    Energy Information Administration (EIA) (indexed site)

    Liquefied Natural Gas Exports to Canada (Million Cubic Feet) Portal, ND Liquefied Natural Gas Exports to Canada (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct ...

  8. Babb, MT Liquefied Natural Gas Exports to Canada (Million Cubic...

    Energy Information Administration (EIA) (indexed site)

    Liquefied Natural Gas Exports to Canada (Million Cubic Feet) Babb, MT Liquefied Natural Gas Exports to Canada (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov ...

  9. Sumas, WA Liquefied Natural Gas Imports from Canada (Million...

    Energy Information Administration (EIA) (indexed site)

    from Canada (Million Cubic Feet) Sumas, WA Liquefied Natural Gas Imports from Canada (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2014 5 2015 4 4 2 1 ...

  10. Secretary Bodman Visits Alberta, Canada | Department of Energy

    Energy Saver

    Secretary Bodman Visits Alberta, Canada July 14, 2006 - 3:09pm Addthis Tour of Oil Sands ... Yesterday, Secretary Bodman toured the oil sands in Fort McMurray, Alberta, Canada with ...

  11. Secretary Bodman Hosts Energy Ministers from Canada and Mexico...

    Energy.gov [DOE] (indexed site)

    Canada is the top supplier of imported crude oil and petroleum products to the United States, accounting for more than 16 percent of total imported crude. Canada's oil sands ...

  12. EA-262-C TransCanada Power Marketing Ltd | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    C TransCanada Power Marketing Ltd EA-262-C TransCanada Power Marketing Ltd Order authorizing TransCanada Power Marketing Ltd to export electric energy to Canada. EA-262-C ...

  13. EA-342-A Royal Bank of Canada | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    -A Royal Bank of Canada EA-342-A Royal Bank of Canada Order authorizing Royal Bank of Canada to export electric energy to Canada. EA-342-A RBC (CN).pdf (1.03 MB) More Documents & Publications EA-328-A RBC Energy Services LP Application to Export Electric Energy OE Docket No. EA-328-A RBC Energy Services LP EA-97-D Portland General Electric Company

  14. Canada-United States Regulatory Cooperation Council Webinar: Proposed

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Approach for Energy Efficiency Standards | Department of Energy Canada-United States Regulatory Cooperation Council Webinar: Proposed Approach for Energy Efficiency Standards Canada-United States Regulatory Cooperation Council Webinar: Proposed Approach for Energy Efficiency Standards This is a presentation from the January 12, 2015 Canada-United States Regulatory Cooperation Council webinar for Natural Resources Canada and the US Department of Energy regarding a proposed approach for energy

  15. Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells

    SciTech Connect

    Vrba, Lukas; Jensen, Taylor J.; Garbe, James C.; Heimark, Ronald L.; Cress, Anne E.; Dickinson, Sally; Stampfer, Martha R.; Futscher, Bernard W.

    2009-12-23

    BACKGROUND: The microRNA-200 family participates in the maintenance of an epithelial phenotype and loss of its expression can result in epithelial to mesenchymal transition (EMT). Furthermore, the loss of expression of miR-200 family members is linked to an aggressive cancer phenotype. Regulation of the miR-200 family expression in normal and cancer cells is not fully understood. METHODOLOGY/ PRINCIPAL FINDINGS: Epigenetic mechanisms participate in the control of miR-200c and miR-141 expression in both normal and cancer cells. A CpG island near the predicted mir-200c/mir-141 transcription start site shows a striking correlation between miR-200c and miR-141 expression and DNA methylation in both normal and cancer cells, as determined by MassARRAY technology. The CpG island is unmethylated in human miR-200/miR-141 expressing epithelial cells and in miR-200c/miR-141 positive tumor cells. The CpG island is heavily methylated in human miR-200c/miR-141 negative fibroblasts and miR-200c/miR-141 negative tumor cells. Mouse cells show a similar inverse correlation between DNA methylation and miR-200c expression. Enrichment of permissive histone modifications, H3 acetylation and H3K4 trimethylation, is seen in normal miR-200c/miR-141-positive epithelial cells, as determined by chromatin immunoprecipitation coupled to real-time PCR. In contrast, repressive H3K9 dimethylation marks are present in normal miR-200c/miR-141-negative fibroblasts and miR-200c/miR-141 negative cancer cells and the permissive histone modifications are absent. The epigenetic modifier drug, 5-aza-2'-deoxycytidine, reactivates miR-200c/miR-141 expression showing that epigenetic mechanisms play a functional role in their transcriptional control. CONCLUSIONS/ SIGNIFICANCE: We report that DNA methylation plays a role in the normal cell type-specific expression of miR-200c and miR-141 and this role appears evolutionarily conserved, since similar results were obtained in mouse. Aberrant DNA methylation of the

  16. miR-92a family and their target genes in tumorigenesis and metastasis

    SciTech Connect

    Li, Molin; Guan, Xingfang; Sun, Yuqiang; Mi, Jun; Shu, Xiaohong; Liu, Fang; Li, Chuangang

    2014-04-15

    The miR-92a family, including miR-25, miR-92a-1, miR-92a-2 and miR-363, arises from three different paralog clusters miR-17-92, miR-106a-363, and miR-106b-25 that are highly conservative in the process of evolution, and it was thought as a group of microRNAs (miRNAs) correlated with endothelial cells. Aberrant expression of miR-92a family was detected in multiple cancers, and the disturbance of miR-92a family was related with tumorigenesis and tumor development. In this review, the progress on the relationship between miR-92a family and their target genes and malignant tumors will be summarized. - Highlights: • Aberrant expression of miR-92a, miR-25 and miR-363 can be observed in many kinds of malignant tumors. • The expression of miR-92a family is regulated by LOH, epigenetic alteration, transcriptional factors such as SP1, MYC, E2F, wild-type p53 etc. • Roles of miR-92a family in tumorigenesis and development: promoting cell proliferation, invasion and metastasis, inhibiting cell apoptosis.

  17. Development and Implementation of the Midwest Geological Sequestration Consortium CO2-Technology Transfer Center

    SciTech Connect

    Greenberg, Sallie E.

    2015-06-30

    In 2009, the Illinois State Geological Survey (ISGS), in collaboration with the Midwest Geological Sequestration Consortium (MGSC), created a regional technology training center to disseminate carbon capture and sequestration (CCS) technology gained through leadership and participation in regional carbon sequestration projects. This technology training center was titled and branded as the Sequestration Training and Education Program (STEP). Over the last six years STEP has provided local, regional, national, and international education and training opportunities for engineers, geologists, service providers, regulators, executives, K-12 students, K-12 educators, undergraduate students, graduate students, university and community college faculty members, and participants of community programs and functions, community organizations, and others. The goal for STEP educational programs has been on knowledge sharing and capacity building to stimulate economic recovery and development by training personnel for commercial CCS projects. STEP has worked with local, national and international professional organizations and regional experts to leverage existing training opportunities and provide stand-alone training. This report gives detailed information on STEP activities during the grant period (2009-2015).

  18. EA-262 TransCanada Power Marketing Ltd | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    TransCanada Power Marketing Ltd EA-262 TransCanada Power Marketing Ltd Order authorizing TransCanada Power Marketing Ltd to export electric energy to Canada. EA-262 TransCanada Power Marketing Ltd (1.41 MB) More Documents & Publications EA-262-A TransCanada Power Marketing Ltd EA-262-C TransCanada Power Marketing Ltd EA-262-B

  19. EA-262-A TransCanada Power Marketing Ltd | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    A TransCanada Power Marketing Ltd EA-262-A TransCanada Power Marketing Ltd Order authorizing TransCanada Power Marketing Ltd to export electric energy to Canada. EA-262-A TransCanada Power Marketing Ltd (1.64 MB) More Documents & Publications EA-262-C TransCanada Power Marketing Ltd EA-262-B TransCanada Power Marketing Ltd EA-262

  20. EA-262-B TransCanada Power Marketing Ltd | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    B TransCanada Power Marketing Ltd EA-262-B TransCanada Power Marketing Ltd Order authorizing TransCanada Power Marketing Ltd to export electric energy to Canada. EA-262-B TransCanada Power Marketing Ltd (1.79 MB) More Documents & Publications EA-262-A TransCanada Power Marketing Ltd EA-262-C TransCanada Power Marketing Ltd EA-262

  1. miR-107 and miR-25 simultaneously target LATS2 and regulate proliferation and invasion of gastric adenocarcinoma (GAC) cells

    SciTech Connect

    Zhang, Mingjun; Wang, Xiaolei; Li, Wanhu; Cui, Yongchun

    2015-05-08

    Although a series of oncogenes and tumor suppressors were identified in the pathological development of gastric adenocarcinoma (GAC), the underlying molecule mechanism were still not fully understood. The current study explored the expression profile of miR-107 and miR-25 in GAC patients and their downstream regulative network. qRT-PCR analysis was performed to quantify the expression of these two miRNAs in serum samples from both patients and healthy controls. Dual luciferase assay was conducted to verify their putative bindings with LATS2. MTT assay, cell cycle assay and transwell assay were performed to explore how miR-107 and miR-25 regulate proliferation and invasion of gastric cancer cells. Findings of this study demonstrated that total miR-107 or miR-25 expression might be overexpressed in gastric cancer patients and they can simultaneously and synchronically regulate LATS2 expression, thereby affecting gastric cancer cell growth and invasion. Therefore, the miR-25/miR-107-LATS2 axis might play an important role in proliferation and invasion of the gastric cancer cells. - Highlights: • Total miR-107 and miR-25 expression is significantly increased in GAC patients. • Both miR-107 and miR-25 can promote proliferation and invasion of GAC cells. • Both miR-107 and miR-25 can target LATS2 and regulate its expression. • miR-107 and miR-25 regulate proliferation and invasion of GAC cells though LATS2.

  2. Development Of Sustainable Biobased Products And Bioenergy In Cooperation With The Midwest Consortium For Sustainable Biobased Products And Energy

    SciTech Connect

    Michael Ladisch; Randy Woodson

    2009-03-18

    Collaborative efforts of Midwest Consortium have been put forth to add value to distiller's grains by further processing them into fermentable sugars, ethanol, and a protein rich co-product consistent with a pathway to a biorenewables industry (Schell et al, 2008). These studies were recently published in the enclosed special edition (Volume 99, Issue 12) of Bioresource Technology journal. Part of them have demonstrated the utilization of distillers grains as additional feedstock for increased ethanol production in the current dry grind process (Kim et al., 2008a, b; Dien et al.,2008, Ladisch et al., 2008a, b). Results showed that both liquid hot water (LHW) pretreatment and ammonia fiber expansion (AFEX) were effective for enhancing digestibility of distiller's grains. Enzymatic digestion of distiller's grains resulted in more than 90% glucose yield under standard assay conditions, although the yield tends to drop as the concentration of dry solids increases. Simulated process mass balances estimated that hydrolysis and fermentation of distillers grains can increase the ethanol yield by 14% in the current dry milling process (Kim et al., 2008c). Resulting co-products from the modified process are richer in protein and oil contents than conventional distiller's grains, as determined both experimentally and computationally. Other research topics in the special edition include water solubilization of DDGS by transesterification reaction with phosphite esters (Oshel el al., 2008) to improve reactivity of the DDGS to enzymes, hydrolysis of soluble oligomers derived from DDGS using functionalized mesoporous solid catalysts (Bootsma et al., 2008), and ABE (acetone, butanol, ethanol) production from DDGS by solventogenic Clostridia (Ezeji and Blaschek, 2008). Economic analysis of a modified dry milling process, where the fiber and residual starch is extracted and fermented to produce more ethanol from the distillers grains while producing highly concentrated protein co

  3. miR-17 inhibitor suppressed osteosarcoma tumor growth and metastasis via increasing PTEN expression

    SciTech Connect

    Gao, Yong; Luo, Ling-hui; Li, Shuai; Yang, Cao

    2014-02-07

    Highlights: • miR-17 was increased in OS tissues and cell lines. • Inhibition of miR-17 suppressed OS cell proliferation. • Inhibition of miR-17 suppressed OS cell migration and invasion. • PTEN was a target of miR-17. • miR-17 was negatively correlated with PTEN in OS tissues. - Abstract: MicroRNAs (miRNAs) play essential roles in cancer development and progression. Here, we investigated the role of miR-17 in the progression and metastasis of osteosarcoma (OS). miR-17 was frequently increased in OS tissues and cell lines. Inhibition of miR-17 in OS cell lines substantially suppressed cell proliferation, migration, and invasion. Phosphatase and tensin homolog (PTEN) was identified as a target of miR-17, and ectopic expression of miR-17 inhibited PTEN by direct binding to its 3′-untranslated region (3′-UTR). Expression of miR-17 was negatively correlated with PTEN in OS tissues. Together, these findings indicate that miR-17 acts as an oncogenic miRNA and may contribute to the progression and metastasis of OS, suggesting miR-17 as a potential novel diagnostic and therapeutic target of OS.

  4. CANADA-UNITED STATES REGULATORY COOPERATION COUNCIL Webinar: Work Plan

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Development - 2016/17; April 12, 2016 | Department of Energy CANADA-UNITED STATES REGULATORY COOPERATION COUNCIL Webinar: Work Plan Development - 2016/17; April 12, 2016 CANADA-UNITED STATES REGULATORY COOPERATION COUNCIL Webinar: Work Plan Development - 2016/17; April 12, 2016 Work Plan and Development 2016-04-12 (207.15 KB) More Documents & Publications Canada-United States Regulatory Cooperation Council Webinar: Proposed Approach for Energy Efficiency Standards North America Energy

  5. New Travel Entry Requirements for Canada Now in Effect

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Travel Entry Requirements for Canada Now in Effect Foreign Nationals previously exempt from visa requirements to enter Canada, are now required to apply for an online Electronic Travel Authorization (eTA) to fly to or transit through Canada. Exceptions who are not required to apply for an eTA include - U.S. citizens, travelers with a valid Canadian visa. Canadian citizens, including dual citizens, and Canadian permanent residents. Lists of countries whose citizens are now required to apply for

  6. Canada-NREL Energy Activities | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    (ICPET) Sector Energy Focus Area Biomass Country Canada Northern America References NREL International Activities Website 1 Abstract NREL is working with the National Research...

  7. Climate, Conservation, and Community in Alaska and Northwest Canada

    Energy.gov [DOE]

    Climate, Conservation, and Community in Alaska and Northwest Canada is a joint Landscape Conservation Cooperative (LCC) and Alaska Climate Science Center (AK CSC) conference scheduled for November...

  8. Natural Resources Canada and DOE Announce Enhanced Energy Collaboration

    Energy.gov [DOE]

    Canada's Minister of Natural Resources Greg Rickford and Secretary Moniz sign a Memorandum of Understanding launching an agreement on enhanced energy collaboration between NRCan and DOE.

  9. 2010 Carbon Sequestration Atlas of the United States and Canada...

    OpenEI (Open Energy Information) [EERE & EIA]

    10 Carbon Sequestration Atlas of the United States and Canada: Third Edition Jump to: navigation, search Tool Summary LAUNCH TOOL Name: 2010 Carbon Sequestration Atlas of the...

  10. DOE, Natural Resources Canada Announce Pilot Plant to Advance

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Oxy-Combustion Carbon Capture | Department of Energy DOE, Natural Resources Canada Announce Pilot Plant to Advance Oxy-Combustion Carbon Capture DOE, Natural Resources Canada Announce Pilot Plant to Advance Oxy-Combustion Carbon Capture October 18, 2016 - 3:30pm Addthis The U.S. Department of Energy (DOE) and Canada's Natural Resources Canada (NRCan) today announced the opening of a new 1 Megawatt Thermal (MWth) facility to test an advanced process to capture carbon dioxide (CO2) emissions

  11. Canada de los Alamos, New Mexico: Energy Resources | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    Canada de los Alamos, New Mexico: Energy Resources Jump to: navigation, search Equivalent URI DBpedia Coordinates 35.5930896, -105.8611303 Show Map Loading map......

  12. NAFTA and gasoline: Canada, U. S. , Mexico

    SciTech Connect

    Not Available

    1993-03-31

    The North American Free Trade Agreement has become a hotly debated topic all over the world, but especially in the countries involved: Mexico, United States, and Canada. Comments made by high ranking officials imply there are differences to reconcile before the agreement is passed. Toward seeing these countries in trio, this issue compares gasoline markets and some energy perspectives. The purpose of this article is to contribute to understanding of the three countries through their petroleum industry structure. Gasoline consumption and retail delivery infrastructure are compared and contrasted to illustrate the differences among the NAFTA countries.

  13. MiR-218 Mediates tumorigenesis and metastasis: Perspectives and implications

    SciTech Connect

    Lu, Ying-fei; Zhang, Li; Waye, Mary Miu Yee; Fu, Wei-ming; Zhang, Jin-fang

    2015-05-15

    MicroRNAs (miRNAs) are a class of small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. As a highly conserved miRNA across a variety of species, microRNA-218 (miR-218) was found to play pivotal roles in tumorigenesis and progression. A group of evidence has demonstrated that miR-218 acts as a tumor suppressor by targeting many oncogenes related to proliferation, apoptosis and invasion. In this review, we provide a complex overview of miR-218, including its regulatory mechanisms, known functions in cancer and future challenges as a potential therapeutic target in human cancers. - Highlights: • miR-218 is frequently down regulated in multiple cancers. • miR-218 plays pivotal roles in carcinogenesis. • miR-218 mediates proliferation, apoptosis, metastasis, invasion, etc. • miR-218 mediates tumorigenesis and metastasis via multiple pathways.

  14. U.S.-Canada Clean Energy Dialogue (CED) Action Plan | Department...

    Energy Saver

    Canada Clean Energy Dialogue (CED) Action Plan U.S.-Canada Clean Energy Dialogue (CED) Action Plan First Report of the U.S.-Canada Clean Energy Dialogue Working Groups PDF icon...

  15. EA-356-A J.P. Morgan Commodities Canada Corporation | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    -A J.P. Morgan Commodities Canada Corporation EA-356-A J.P. Morgan Commodities Canada Corporation Order authorizing JPMCCC to export electric energy to Canada. EA-356-A J.P. Morgan ...

  16. ENG-Canada-USA Government Procurement (clean 11 Feb 2010 printed...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ENG-Canada-USA Government Procurement (clean 11 Feb 2010 printed) ENG-Canada-USA Government Procurement (clean 11 Feb 2010 printed) ENG-Canada-USA Government Procurement (clean 11 ...

  17. BC Hydro Brings Energy Savings to Low-Income Families in Canada...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    BC Hydro Brings Energy Savings to Low-Income Families in Canada BC Hydro Brings Energy Savings to Low-Income Families in Canada The number of British Columbia, Canada, households ...

  18. U.S.-Canada Clean Energy Dialogue Report | Department of Energy

    Office of Environmental Management (EM)

    U.S.-Canada Clean Energy Dialogue Report U.S.-Canada Clean Energy Dialogue Report PDF icon CEDReporttoLeaders.pdf More Documents & Publications U.S.-Canada Clean Energy Dialogue...

  19. One-way coupling of an integrated assessment model and a water resources model: evaluation and implications of future changes over the US Midwest

    SciTech Connect

    Voisin, Nathalie; Liu, Lu; Hejazi, Mohamad I.; Tesfa, Teklu K.; Li, Hongyi; Huang, Maoyi; Liu, Ying; Leung, Lai-Yung R.

    2013-11-18

    An integrated model is being developed to advance our understanding of the interactions between human activities, terrestrial system and water cycle, and how system interactions will be affected by a changing climate at the regional scale. As a first step towards that goal, a global integrated assessment model including a waterdemand model is coupled offline with a land surface hydrology routing water resources management model. A spatial and temporal disaggregation approach is developed to project the annual regional water demand simulations into a daily time step and subbasin representation. The model demonstrated reasonable ability to represent the historical flow regulation and water supply over the Midwest (Missouri, Upper Mississippi and Ohio). Implications for the future flow regulation, water supply and supply deficit are investigated using a climate change projection with the B1 emission scenario which affects both natural flow and water demand. Over the Midwest, changes in flow regulation are mostly driven by the change in natural flow due to the limited storage capacity over the Ohio and Upper Mississippi river basins. The changes in flow and demand have a combined effect on the Missouri Summer regulated flow. The supply deficit tends to be driven by the change in flow over the region. Spatial analysis demonstrates the relationship between the supply deficit and the change in demand over urban areas not along a main river or with limited storage, and over areas upstream of groundwater dependent fields with therefore overestimated demand.

  20. U.S. - Canada Power System Outage Task Force: Final Report on...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    - Canada Power System Outage Task Force: Final Report on the Implementation of Task Force Recommendations U.S. - Canada Power System Outage Task Force: Final Report on the ...

  1. NuMI Low Energy Flux Prediction Release

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    NuMI Low Energy Flux Prediction Release Neutrino Flux Predictions for the NuMI Beam hep-ex/1607.00704 Data Ancillary data files for this result are available on arXiv at http://arxiv.org/src/1607.00704/anc Among the available data files are: pdf file describing format of all the available files root file of all the available fluxes python code to read and process MINERvA's flux predictions Text Files of the flux, uncertainties, and covariance matrix, with units of neutrinos/m^2/POT, in 0.5 GeV

  2. miRNA-205 affects infiltration and metastasis of breast cancer

    SciTech Connect

    Wang, Zhouquan; Department of Tumor, SenGong Hospital of Shaanxi, Xian 710300 ; Liao, Hehe; Deng, Zhiping; Yang, Po; Du, Ning; Zhanng, Yunfeng; Ren, Hong

    2013-11-08

    Highlights: We detected expression of miR-205 in breast cancer cell lines and tissue samples. We suggest miR-205 is downregulated in human breast cancer tissues and MCF7 cells. We suggest the lower expression of miR-205 play a role in breast cancer onset. These data suggest that miR-205 directly targets HER3 in human breast cancer. -- Abstract: Background: An increasing number of studies have shown that miRNAs are commonly deregulated in human malignancies, but little is known about the function of miRNA-205 (miR-205) in human breast cancer. The present study investigated the influence of miR-205 on breast cancer malignancy. Methods: The expression level of miR-205 in the MCF7 breast cancer cell line was determined by quantitative (q)RT-PCR. We then analyzed the expression of miR-205 in breast cancer and paired non-tumor tissues. Finally, the roles of miR-205 in regulating tumor proliferation, apoptosis, migration, and target gene expression were studied by MTT assay, flow cytometry, qRT-PCR, Western blotting and luciferase assay. Results: miR-205 was downregulated in breast cancer cells or tissues compared with normal breast cell lines or non-tumor tissues. Overexpression of miR-205 reduced the growth and colony-formation capacity of MCF7 cells by inducing apoptosis. Overexpression of miR-205 inhibited MCF7 cell migration and invasiveness. By bioinformation analysis, miR-205 was predicted to bind to the 3? untranslated regions of human epidermal growth factor receptor (HER)3 mRNA, and upregulation of miR-205 reduced HER3 protein expression. Conclusion: miR-205 is a tumor suppressor in human breast cancer by post-transcriptional inhibition of HER3 expression.

  3. Ground Motion Studies at NuMI

    SciTech Connect

    Mayda M. Velasco; Michal Szleper

    2012-02-20

    Ground motion can cause significant deterioration in the luminosity of a linear collider. Vibration of numerous focusing magnets causes continuous misalignments, which makes the beam emittance grow. For this reason, understanding the seismic vibration of all potential LC sites is essential and related efforts in many sites are ongoing. In this document we summarize the results from the studies specific to Fermilab grounds as requested by the LC project leader at FNAL, Shekhar Mishra in FY04-FY06. The Northwestern group focused on how the ground motion effects vary with depth. Knowledge of depth dependence of the seismic activity is needed in order to decide how deep the LC tunnel should be at sites like Fermilab. The measurements were made in the NuMI tunnel, see Figure 1. We take advantage of the fact that from the beginning to the end of the tunnel there is a height difference of about 350 ft and that there are about five different types of dolomite layers. The support received allowed to pay for three months of salary of Michal Szleper. During this period he worked a 100% of his time in this project. That include one week of preparation: 2.5 months of data taking and data analysis during the full period of the project in order to guarantee that we were recording high quality data. We extended our previous work and made more systematic measurements, which included detailed studies on stability of the vibration amplitudes at different depths over long periods of time. As a consequence, a better control and more efficient averaging out of the daytime variation effects were possible, and a better study of other time dependences before the actual depth dependence was obtained. Those initial measurements were made at the surface and are summarized in Figure 2. All measurements are made with equipment that we already had (two broadband seismometers KS200 from GEOTECH and DL-24 portable data recorder). The offline data analysis took advantage of the full Fourier spectra

  4. Midwest Forensics Resource Center

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Chromatography-Mass Spectrometry and Liquid Chromatography-Mass Spectrometry for Discrimination of Salvia divinorum from Related Salvia Species Using Chemometric...

  5. Midwest Building Energy Program

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ... * Adjust Energy Conservation Measure (ECM) Requirements to Meet Opposition Critics and State Code Mandates * Develop an Implementation Plan Simultaneously but Separately ...

  6. Midwest Energy Codes Project

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ... MEEA Policy Funds 100K+ for benchmarking IL Dept. of Commerce & Economic Opportunity 155K for CANDI compliance program Budget History FY2012 - FY2013 (past) FY2014 ...

  7. Taxation of oil and gas revenues: Canada

    SciTech Connect

    Helliwell, J.F.

    1982-04-01

    The policy of Canadianization must be included in any analysis of energy taxation in Canada, where energy resources are unevenly divided among the provinces. The provinces own most natural resources, but the oil and gas industry is dominated by foreign ownership and control. The Federal National Energy Program (NEP) of 1980 target of 50% Canadian ownership by 1990 conflicts with provincial practices by shifting incentives from depletion allowance to ownership grants for buy backs. The NEP compares unfavorably with US taxation, and that, combined with US deregulation, has shifted drilling activity to the US. The controversial tax elements do compare with those of the United Kingdom and other North Sea producers. Although recent controversy has caused investors to defer projects, Canadian investment is competitive with most countries. 5 references, 1 table. (DCK)

  8. Bitumen and heavy oil upgrading in Canada

    SciTech Connect

    Chrones, J. ); Germain, R.R. )

    1989-01-01

    A review is presented of the heavy oil upgrading industry in Canada. Up to now it has been based on the processing of bitumen extracted from oil sands mining operations at two sites, to produce a residue-free, low sulphur, synthetic crude. Carbon rejection has been the prime process technology with delayed coking being used by Suncor and FLUID COKING at Syncrude. Alternative processes for recovering greater amounts of synthetic crude are examined. These include a variety of hydrogen addition processes and combinations which produce pipelineable materials requiring further processing in downstream refineries with expanded capabilities. The Newgrade Energy Inc. upgrader now under construction in Regina, will use fixed-bed, catalytic, atmospheric-residue, hydrogen processing. Two additional projects, also based on hydrogenation, will use ebullated bed catalyst systems; the expansion of Syncrude, now underway, is using the LC Fining Process whereas the announced Husky Bi-Provincial upgrader is based on H-Oil.

  9. Bitumen and heavy oil upgrading in Canada

    SciTech Connect

    Chrones, J.

    1988-06-01

    A review is presented of the heavy oil upgrading industry in Canada. Up to now it has been based on the processing of bitumen extracted from oil sands mining operations at two sites, to produce a residue-free, low sulfur, synthetic crude. Carbon rejection has been the prime process technology with delayed coking being used by Suncor and FLUID COKING at Syncrude. Alternative processes for recovering greater amounts of synthetic crude are examined. These include a variety of hydrogen addition processes and combinations which produce pipelineable materials requiring further processing in downstream refineries with expanded capabilities. The Newgrade Energy Inc. upgrader, now under construction in Regina, will use fixed-bed, catalytic, atmospheric-residue, hydrogen processing. Two additional products, also based on hydrogenation, will use ebullated bed catalyst systems: the expansion of Syncrude, now underway, is using the LC Fining Process whereas the announced Husky Bi-Provincial upgrader is based on H-Oil.

  10. Application to Export Electric Energy OE Docket No. 326-A Citigroup Energy Canada ULC: Federal Register Notice, Volume 77, No. 75- April 18, 2012

    Energy.gov [DOE]

    Application from Citigroup Energy Canada ULC to export electric energy to Canada. Federal Register Notice.

  11. DOE - Office of Legacy Management -- Mitts-Merrill Co - MI 14

    Office of Legacy Management (LM)

    1993 MI.14-2 Site Operations: Reduced thorium metal chunks into particle sized pieces ... Primary Radioactive Materials Handled: Thorium MI.14-1 Radiological Survey(s): Yes - ...

  12. DOE - Office of Legacy Management -- Mitts-Merrel Co - MI 14

    Office of Legacy Management (LM)

    1993 MI.14-2 Site Operations: Reduced thorium metal chunks into particle sized pieces ... Primary Radioactive Materials Handled: Thorium MI.14-1 Radiological Survey(s): Yes - ...

  13. MiR-125a TNF receptor-associated factor 6 to inhibit osteoclastogenesis

    SciTech Connect

    Guo, Li-Juan; Liao, Lan; Yang, Li; Li, Yu; Jiang, Tie-Jian

    2014-02-15

    MicroRNAs (miRNAs) play important roles in osteoclastogenesis and bone resorption. In the present study, we found that miR-125a was dramatically down-regulated during macrophage colony stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ligand (RANKL) induced osteoclastogenesis of circulating CD14+ peripheral blood mononuclear cells (PBMCs). Overexpression of miR-125a in CD14+ PBMCs inhibited osteoclastogenesis, while inhibition of miR-125a promoted osteoclastogenesis. TNF receptor-associated factor 6 (TRAF6), a transduction factor for RANKL/RANK/NFATc1 signal, was confirmed to be a target of miR-125a. EMSA and ChIP assays confirmed that NFATc1 bound to the promoter of the miR-125a. Overexpression of NFATc1 inhibited miR-125a transcription, and block of NFATc1 expression attenuated RANKL-regulated miR-125a transcription. Here, we reported that miR-125a played a biological function in osteoclastogenesis through a novel TRAF6/ NFATc1/miR-125a regulatory feedback loop. It suggests that regulation of miR-125a expression may be a potential strategy for ameliorating metabolic disease. - Highlights: • MiR-125a was significantly down-regulated in osteoclastogenesis of CD14+ PBMCs. • MiR-125a inhibited osteoclast differentiation by targeting TRAF6. • NFATc1 inhibited miR-125a transciption by binding to the promoter of miR-125a. • TRAF6/NFATc1 and miR-125a form a regulatory feedback loop in osteoclastogenesis.

  14. Port Huron, MI Liquefied Natural Gas Exports (Million Cubic Feet...

    Energy Information Administration (EIA) (indexed site)

    (Million Cubic Feet) Port Huron, MI Liquefied Natural Gas Exports (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2013 1 2014 1 1 1 1 2 1 1 1 1 1 2015 1 1...

  15. Neutron scattering study of spin ordering and stripe pinning in superconducting <mi>La>1.93<mi>Sr>0.07<mi>CuO>4

    SciTech Connect

    Jacobsen, H.; Zaliznyak, I. A.; Savici, A. T.; Winn, B. L.; Chang, S.; Hücker, M.; Gu, G. D.; Tranquada, J. M.

    2015-11-20

    The relationships among charge order, spin fluctuations, and superconductivity in underdoped cuprates remain controversial. We use neutron scattering techniques to study these phenomena in <mi>La>1.93<mi>Sr>0.07<mi>CuO>4 a superconductor with a transition temperature of Tc = 20 K. At T<< Tc, we find incommensurate spin fluctuations with a quasielastic energy spectrum and no sign of a gap within the energy range from 0.2 to 15 meV. A weak elastic magnetic component grows below ~ 10 K, consistent with results from local probes. Regarding the atomic lattice, we have discovered unexpectedly strong fluctuations of the CuO6 octahedra about Cu-O bonds, which are associated with inequivalent O sites within the CuO2 planes. Moreover, we observed a weak elastic (3 30) superlattice peak that implies a reduced lattice symmetry. The presence of inequivalent O sites rationalizes various pieces of evidence for charge stripe order in underdoped La2-xSrxCuO4. The coexistence of superconductivity with quasi-static spin-stripe order suggests the presence of intertwined orders; however, the rotation of the stripe orientation away from the Cu-O bonds might be connected with evidence for a finite gap at the nodal points of the superconducting gap function.

  16. MiR-145 functions as a tumor suppressor targeting NUAK1 in human intrahepatic cholangiocarcinoma

    SciTech Connect

    Xiong, Xinkui; Sun, Daoyi; Chai, Hao; Shan, Wengang; Yu, Yue; Pu, Liyong; Cheng, Feng

    2015-09-18

    The dysregulation of micro (mi)RNAs is associated with cancer development. The miRNA miR-145 is downregulated in intrahepatic cholangiocarcinoma (ICC); however, its precise role in tumor progression has not yet been elucidated. Novel (nua) kinase family (NUAK)1 functions as an oncogene in various cancers and is a putative target of miR-145 regulation. In this study, we investigated the regulation of NUAK1 by miR-145 in ICC. We found that miR-145 level was significantly decreased in ICC tissue and cell lines, which corresponded with an increase in NUAK1 expression. NUAK1 was found to be a direct target of miR-145 regulation. The overexpression of miR-145 in ICC cell lines inhibited proliferation, growth, and invasion by suppressing NUAK1 expression, which was associated with a decrease in Akt signaling and matrix metalloproteinase protein expression. Similar results were observed by inhibiting NUAK1 expression. These results demonstrate that miR-145 can prevent ICC progression by targeting NUAK1 and its downstream effectors, and can therefore be useful for clinical diagnosis and targeted therapy of ICC. - Highlights: • MiR-145 suppresses ICC proliferation and invasion abilities. • We demonstrated that miR-145 directly targets NUAK1 in ICC. • MiR-145 expression in ICC was associated with Akt signaling and MMPs expression.

  17. Radiosensitizing Effects of Ectopic miR-101 on Non-Small-Cell Lung Cancer Cells Depend on the Endogenous miR-101 Level

    SciTech Connect

    Chen, Susie; Wang Hongyan; Ng, Wooi Loon; Curran, Walter J.; Wang Ya

    2011-12-01

    Purpose: Previously, we showed that ectopic miR-101 could sensitize human tumor cells to radiation by targeting ATM and DNA-PK catalytic subunit (DNA-PKcs) to inhibit DNA repair, as the endogenous miR-101 levels are low in tumors in general. However, the heterogeneity of human cancers may result in an exception. The purpose of this study was to test the hypothesis that a few tumor cell lines with a high level of endogenous miR-101 would prove less response to ectopic miR-101. Methods and Materials: Fourteeen non-small-cell lung cancer (NSCLC) cell lines and one immortalized non-malignant lung epithelial cell line (NL20) were used for comparing endogenous miR-101 levels by real-time reverse transcription-polymerase chain reaction. Based on the different miR-101 levels, four cell lines with different miR-101 levels were chosen for transfection with a green fluorescent protein-lentiviral plasmid encoding miR-101. The target protein levels were measured by using Western blotting. The radiosensitizing effects of ectopic miR-101 on these NSCLC cell lines were determined by a clonogenic assay and xenograft mouse model. Results: The endogenous miR-101 level was similar or lower in 13 NSCLC cell lines but was 11-fold higher in one cell line (H157) than in NL20 cells. Although ectopic miR-101 efficiently decreased the ATM and DNA-PKcs levels and increased the radiosensitization level in H1299, H1975, and A549 cells, it did not change the levels of the miR-101 targets or radiosensitivity in H157 cells. Similar results were observed in xenograft mice. Conclusions: A small number of NSCLC cell lines could have a high level of endogenous miR-101. The ectopic miR-101 was able to radiosensitize most NSCLC cells, except for the NSCLC cell lines that had a much higher endogenous miR-101 level. These results suggest that when we choose one miRNA as a therapeutic tool, the endogenous level of the miRNA in each tumor should be considered.

  18. Heavy oil development in Canada - The need for upgrading

    SciTech Connect

    Quinn, P.C.

    1987-01-01

    The author first reviews Canada's petroleum reserves, then summarizes the problem facing Canada regarding dwindling supplies of conventional light and medium crude oils and briefly describes Canada's refining capability. With that background, he attempts to analyze the problems that face heavy oil producers in attempting to market their product and propose a potential solution to these problems as illustrated by Husky Oil's approach - the construction of a heavy oil upgrader. He closes by sharing his views on the future of heavy oil development and the policy issues facing our governments.

  19. Canada's heavy oil, bitumen upgrading activity is growing

    SciTech Connect

    Corbett, R.A.

    1989-06-26

    Heavy oil and bitumen upgrading activity in Canada is surging with the recent start-up of two new upgraders and with plans to build others. These new upgraders make use of modern hydrocracking technology. Articles in this special report on upgrading focus on Canada's oil and bitumen reserves, the promising technologies that upgrade them, and present details of some of the current upgrader projects. This article covers the following areas: Canada's heavy oils; Upgrading expands; Upgrading technologies; Test results; Regional upgraders; High-quality light product.

  20. Portal, ND Natural Gas Liquefied Natural Gas Imports from Canada (Million

    Energy Information Administration (EIA) (indexed site)

    Cubic Feet) Natural Gas Imports by Pipeline from Canada

  1. TransCanada Power Mktg Ltd (Connecticut) | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Connecticut Phone Number: 1.800.661.3805 Website: www.transcanada.compowermarke Twitter: @TransCanada Outage Hotline: 1-800-447-8066 References: EIA Form EIA-861 Final Data...

  2. TransCanada Energy Marketing ULC | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Marketing ULC Jump to: navigation, search Name: TransCanada Energy Marketing ULC Place: California References: EIA Form EIA-861 Final Data File for 2010 - File1a1 EIA Form 861...

  3. Portal, ND Compressed Natural Gas Exports to Canada (Dollars...

    Energy Information Administration (EIA) (indexed site)

    Dollars per Thousand Cubic Feet) Portal, ND Compressed Natural Gas Exports to Canada (Dollars per Thousand Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2015 ...

  4. Portal, ND Compressed Natural Gas Exports to Canada (Million...

    Energy Information Administration (EIA) (indexed site)

    Million Cubic Feet) Portal, ND Compressed Natural Gas Exports to Canada (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2015 0 2 - No Data Reported; -- ...

  5. Calais, ME Compressed Natural Gas Exports to Canada (Dollars...

    Energy Information Administration (EIA) (indexed site)

    Dollars per Thousand Cubic Feet) Calais, ME Compressed Natural Gas Exports to Canada (Dollars per Thousand Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2013 ...

  6. Calais, ME Compressed Natural Gas Exports to Canada (Million...

    Energy Information Administration (EIA) (indexed site)

    Million Cubic Feet) Calais, ME Compressed Natural Gas Exports to Canada (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2013 1 24 19 15 3 8 23 22 2014 32 ...

  7. An Embarrassment Of Riches- Canada'S Energy Supply Resources...

    OpenEI (Open Energy Information) [EERE & EIA]

    fuel-mix in Canada from 1870 to 1984, and the current provincial breakdown of energy production and use, we provide a source-by-source review of energy supply resources,...

  8. International Falls, MN Natural Gas Pipeline Imports From Canada...

    Energy Information Administration (EIA) (indexed site)

    Million Cubic Feet) International Falls, MN Natural Gas Pipeline Imports From Canada (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 ...

  9. Warroad, MN Natural Gas Pipeline Exports to Canada (Million Cubic...

    Energy Information Administration (EIA) (indexed site)

    to Canada (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's NA 2000's NA NA NA 0 - No Data Reported; -- Not Applicable; ...

  10. Havre, MT Natural Gas Pipeline Imports From Canada (Million Cubic...

    Energy Information Administration (EIA) (indexed site)

    Million Cubic Feet) Havre, MT Natural Gas Pipeline Imports From Canada (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's NA ...

  11. North Troy, VT Natural Gas Pipeline Imports From Canada (Million...

    Energy Information Administration (EIA) (indexed site)

    Million Cubic Feet) North Troy, VT Natural Gas Pipeline Imports From Canada (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's ...

  12. North Troy, VT Natural Gas Pipeline Imports From Canada (Dollars...

    Energy Information Administration (EIA) (indexed site)

    Dollars per Thousand Cubic Feet) North Troy, VT Natural Gas Pipeline Imports From Canada (Dollars per Thousand Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 ...

  13. Canada Mexico Figure 11. Flow of natural gas exports, 2014

    Energy Information Administration (EIA) (indexed site)

    8 Canada Mexico Figure 11. Flow of natural gas exports, 2014 (billion cubic feet) Source: Energy Information Administration, based on data from the Office of Fossil Energy, U.S. ...

  14. Application to export electric energy OE docket No. EA-262-C TransCanada

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Power Marketing Ltd | Department of Energy docket No. EA-262-C TransCanada Power Marketing Ltd Application to export electric energy OE docket No. EA-262-C TransCanada Power Marketing Ltd Application from TransCanada Power Marketing Ltd to export electric energy to Canada. Application to export electric energy OE docket No. EA-262-C TransCanada Power Marketing Ltd (1.02 MB) More Documents & Publications EA-262-C TransCanada Power Marketing Ltd EA-262-A TransCanada Power Marketing Ltd

  15. Taxation and regulation of uranium mining in Canada

    SciTech Connect

    1990-11-01

    Government taxation and regulation have a profound influence on mineral operations. In Canada, taxation occurs both on the federal and provincial levels. In addition, both federal and provincial regulations also affect mine operations, sometimes with overlapping, or conflicting, legislation and jurisdiction. Three broad areas of regulation affect the mine production of uranium in Canada: (1) mining law or mineral rights; (2) the licensing procedures; and (3) regulation of occupational health and safety.

  16. PP-85-2 Boliden Westmin (Canada) Limited | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    5-2 Boliden Westmin (Canada) Limited PP-85-2 Boliden Westmin (Canada) Limited Presidential Permit authorizing Boliden Westmin (Canada) Limited to construct, operate and maintain electric transmission facilities at the U.S. - Canada Border. PP-85-2 Boliden Westmin (Canada) Limited (744.86 KB) More Documents & Publications PP-85-3 Boliden Power Limited PP-85-A Westmin Mines, Inc. PP-85 Westmin Resources

  17. EA-344 Twin Cities Power-Canada, LLC | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    44 Twin Cities Power-Canada, LLC EA-344 Twin Cities Power-Canada, LLC Order authorizing Twin Cities Power-Canada, LLC to export electric energy to Canada EA- 344 Twin Cities Power-Canada, LLC (2.94 MB) More Documents & Publications EA-344-A Twin Cities Power EA-358 Twin Cities Energy, LLC EA-324 Emera Energy Services Subsidiary No. 4 LLC

  18. PPARγ inhibits ovarian cancer cells proliferation through upregulation of miR-125b

    SciTech Connect

    Luo, Shuang; Wang, Jidong; Ma, Ying; Yao, Zhenwei; Pan, Hongjuan

    2015-06-26

    miR-125b has essential roles in coordinating tumor proliferation, angiogenesis, invasiveness, metastasis and chemotherapy recurrence. In ovarian cancer miR-125b has been shown to be downregulated and acts as a tumor suppressor by targeting proto-oncogene BCL3. PPARγ, a multiple functional transcription factor, has been reported to have anti-tumor effects through inhibition of proliferation and induction of differentiation and apoptosis by targeting the tumor related genes. However, it is unclear whether miR-125b is regulated by PPARγ in ovarian cancer. In this study, we demonstrated that the miR-125b downregulated in ovarian cancer tissues and cell lines. Ligands-activated PPARγ suppressed proliferation of ovarian cancer cells and this PPARγ-induced growth inhibition is mediated by the upregulation of miR-125b. PPARγ promoted the expression of miR-125b by directly binding to the responsive element in miR-125b gene promoter region. Thus, our results suggest that PPARγ can induce growth suppression of ovarian cancer by upregulating miR-125b which inhibition of proto-oncogene BCL3. These findings will extend our understanding of the function of PPARγ in tumorigenesis and miR-125b may be a therapeutic intervention of ovarian cancer. - Highlights: • miR-125b is down-regulated in ovarian cancer tissues and cells. • PPARγ upregulates miR-125b and downregulates its target gene BCL3 expression. • Silence of miR-125b attenuates PPARγ-mediated growth suppression of ovarian cancer cells. • PPARγ promotes the transcription of miR-125b via binding to PPARE in miR-125b gene promoter region.

  19. The role and future of nuclear power in Canada

    SciTech Connect

    Runnalls, O.J.C.

    1989-01-01

    Canada is rich in energy. Hydraulic power is the main source of electricity in Canada. The availability of natural resources and energy has guided the economic development of all the provinces. The Canadian Nuclear Association sponsored a survey of public attitudes in May of 1988. There appears to be less understanding of the actual supply of electricity and of the future natural resource availability. One out of five Canadians strongly opposes the use of nuclear energy. The CANDU type reactor proven to be a very economical and reliable choice in Canada. With the attention now being focused on the greenhouse effect and acid rain in Canada, opinion leaders, even in the traditionally antinuclear environmental community, are reconsidering the nuclear option. A significant hurdle has to be cleared in the relatively near future: a public review of the deep geologic high-level waste disposal concept. Groundwork has been laid to prepare for significant participation in a nuclear renaissance, across Canada and around the world.

  20. U.S.-CANADA CLEAN ENERGY DIALOGUE (CED) THIRD REPORT TO LEADERS |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy U.S.-CANADA CLEAN ENERGY DIALOGUE (CED) THIRD REPORT TO LEADERS U.S.-CANADA CLEAN ENERGY DIALOGUE (CED) THIRD REPORT TO LEADERS The Third Report to the President of the United States of America and the Prime Minister of Canada. Third Report to Leaders (537.32 KB) More Documents & Publications U.S.-Canada Clean Energy Dialogue (CED) Action Plan II U.S.-Canada Clean Energy Dialogue (CED) Action Plan II U.S.-Canada Clean Energy Dialogue (CED) Report to Leaders

  1. 9000 wells planned for heavy oil field. [Canada

    SciTech Connect

    Not Available

    1981-05-01

    Beginning in 1983, Esso Resources Canada Ltd. will begin drilling the first of an estimated 9000 directional crude bitumen wells in the tar sands at Cold Lake, Alberta, Canada, the final wells being drilled in the year 2008. The area, covering 50 sq miles of extreme E. Alberta along the Saskatchewan border, contains one of the richest deposits of heavy oil sands in Canada. The company and future partners will drill the bitumen wells directionally into the shallow clearwater formation, which can be reached at approx. 100 m (330 ft). The formation contains an estimated 80 billion bbl of crude bitumen at a rate of 60,000 bpd for 25 yr. This volume of crude will be refined in an upgrading plant to 140,000 bpd of synthetic crude oil. When completed, the Cold Lake project will be one of the largest facilities for producing crude bitumen from wells in the world.

  2. Genome-Wide Analysis of miRNA targets in Brachypodium and Biomass Energy Crops

    SciTech Connect

    Green, Pamela J.

    2015-08-11

    MicroRNAs (miRNAs) contribute to the control of numerous biological processes through the regulation of specific target mRNAs. Although the identities of these targets are essential to elucidate miRNA function, the targets are much more difficult to identify than the small RNAs themselves. Before this work, we pioneered the genome-wide identification of the targets of Arabidopsis miRNAs using an approach called PARE (German et al., Nature Biotech. 2008; Nature Protocols, 2009). Under this project, we applied PARE to Brachypodium distachyon (Brachypodium), a model plant in the Poaceae family, which includes the major food grain and bioenergy crops. Through in-depth global analysis and examination of specific examples, this research greatly expanded our knowledge of miRNAs and target RNAs of Brachypodium. New regulation in response to environmental stress or tissue type was found, and many new miRNAs were discovered. More than 260 targets of new and known miRNAs with PARE sequences at the precise sites of miRNA-guided cleavage were identified and characterized. Combining PARE data with the small RNA data also identified the miRNAs responsible for initiating approximately 500 phased loci, including one of the novel miRNAs. PARE analysis also revealed that differentially expressed miRNAs in the same family guide specific target RNA cleavage in a correspondingly tissue-preferential manner. The project included generation of small RNA and PARE resources for bioenergy crops, to facilitate ongoing discovery of conserved miRNA-target RNA regulation. By associating specific miRNA-target RNA pairs with known physiological functions, the research provides insights about gene regulation in different tissues and in response to environmental stress. This, and release of new PARE and small RNA data sets should contribute basic knowledge to enhance breeding and may suggest new strategies for improvement of biomass energy crops.

  3. DLEU2, frequently deleted in malignancy, functions as a critical host gene of the cell cycle inhibitory microRNAs miR-15a and miR-16-1

    SciTech Connect

    Lerner, Mikael; Harada, Masako; Loven, Jakob; Castro, Juan; Davis, Zadie; Oscier, David; Henriksson, Marie; Sangfelt, Olle; Grander, Dan; Corcoran, Martin M.

    2009-10-15

    The microRNAs miR-15a and miR-16-1 are downregulated in multiple tumor types and are frequently deleted in chronic lymphocytic leukemia (CLL), myeloma and mantle cell lymphoma. Despite their abundance in most cells the transcriptional regulation of miR-15a/16-1 remains unclear. Here we demonstrate that the putative tumor suppressor DLEU2 acts as a host gene of these microRNAs. Mature miR-15a/miR-16-1 are produced in a Drosha-dependent process from DLEU2 and binding of the Myc oncoprotein to two alterative DLEU2 promoters represses both the host gene transcript and levels of mature miR-15a/miR-16-1. In line with a functional role for DLEU2 in the expression of the microRNAs, the miR-15a/miR-16-1 locus is retained in four CLL cases that delete both promoters of this gene and expression analysis indicates that this leads to functional loss of mature miR-15a/16-1. We additionally show that DLEU2 negatively regulates the G1 Cyclins E1 and D1 through miR-15a/miR-16-1 and provide evidence that these oncoproteins are subject to miR-15a/miR-16-1-mediated repression under normal conditions. We also demonstrate that DLEU2 overexpression blocks cellular proliferation and inhibits the colony-forming ability of tumor cell lines in a miR-15a/miR-16-1-dependent way. Together the data illuminate how inactivation of DLEU2 promotes cell proliferation and tumor progression through functional loss of miR-15a/miR-16-1.

  4. Microfluidic Molecular Assay Platform for the Detection of miRNAs...

    Office of Scientific and Technical Information (OSTI)

    Article: Microfluidic Molecular Assay Platform for the Detection of miRNAs, mRNAs, Proteins, and Post-translational Modifications at Single-cell Resolution. Citation Details...

  5. DOE - Office of Legacy Management -- Baker-Perkins Co - MI 13

    Office of Legacy Management (LM)

    Site Disposition: Eliminated - Potential for contamination remote based on limited scope of activities at the site MI.13-3 Radioactive Materials Handled: Yes Primary ...

  6. Country Report on Building Energy Codes in Canada

    SciTech Connect

    Shui, Bin; Evans, Meredydd

    2009-04-06

    This report is part of a series of reports on building energy efficiency codes in countries associated with the Asian Pacific Partnership (APP) - Australia, South Korea, Japan, China, India, and the United States of America . This reports gives an overview of the development of building energy codes in Canada, including national energy policies related to building energy codes, history of building energy codes, recent national projects and activities to promote building energy codes. The report also provides a review of current building energy codes (such as building envelope, HVAC, lighting, and water heating) for commercial and residential buildings in Canada.

  7. Champlain, NY Natural Gas Liquefied Natural Gas Imports from Canada

    Energy Information Administration (EIA) (indexed site)

    (Million Cubic Feet) from Canada (Million Cubic Feet) Champlain, NY Natural Gas Liquefied Natural Gas Imports from Canada (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2014 63 2015 1 2 1 2 20 2016 56 76 20 20 3 4 3 4 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Liquefied Natural Gas Imports by Point of Entry

  8. miR-4295 promotes cell proliferation and invasion in anaplastic thyroid carcinoma via CDKN1A

    SciTech Connect

    Shao, Mingchen; Geng, Yiwei; Lu, Peng; Xi, Ying; Wei, Sidong; Wang, Liuxing; Fan, Qingxia; Ma, Wang

    2015-09-04

    MicroRNAs (miRNAs) play important roles in the pathogenesis of many types of cancers by negatively regulating gene expression at posttranscriptional level. However, the role of microRNAs in anaplastic thyroid carcinoma (ATC), has remained elusive. Here, we identified that miR-4295 promotes ATC cell proliferation by negatively regulates its target gene CDKN1A. In ATC cell lines, CCK-8 proliferation assay indicated that the cell proliferation was promoted by miR-4295, while miR-4295 inhibitor significantly inhibited the cell proliferation. Transwell assay showed that miR-4295 mimics significantly promoted the migration and invasion of ATC cells, whereas miR-4295 inhibitors significantly reduced cell migration and invasion. luciferase assays confirmed that miR-4295 directly bound to the 3'untranslated region of CDKN1A, and western blotting showed that miR-4295 suppressed the expression of CDKN1A at the protein levels. This study indicated that miR-4295 negatively regulates CDKN1A and promotes proliferation and invasion of ATC cell lines. Thus, miR-4295 may represent a potential therapeutic target for ATC intervention. - Highlights: • miR-4295 mimics promote the proliferation and invasion of ATC cells. • miR-4295 inhibitors inhibit the proliferation and invasion of ATC cells. • miR-4295 targets 3′UTR of CDKN1A in ATC cells. • miR-4295 negatively regulates CDKN1A in ATC cells.

  9. Groundwater protection for the NuMI project

    SciTech Connect

    Wehmann, A.; Smart, W.; Menary, S.; Hylen, J.; Childress, S.

    1997-10-01

    The physics requirements for the long base line neutrino oscillation experiment MINOS dictate that the NuMI beamline be located in the aquifer at Fermilab. A methodology is described for calculating the level of radioactivation of groundwater caused by operation of this beamline. A conceptual shielding design for the 750 meter long decay pipe is investigated which would reduce radioactivation of the groundwater to below government standards. More economical shielding designs to meet these requirements are being explored. Also, information on local geology, hydrogeology, government standards, and a glossary have been included.

  10. Department of Energy, Shell Canada to Collaborate on CO2 Storage...

    Office of Environmental Management (EM)

    Energy, Shell Canada to Collaborate on CO2 Storage Project Department of Energy, Shell Canada to ... information that would benefit future large-scale CCS projects around the world. ...

  11. Blackout 2003: U.S. - Canada Task Force Presents Final Report...

    Energy Saver

    U.S. Secretary of Energy, and the Honorable R. John Efford, Minister of Natural Resources Canada, released the Final Report of the U.S. -Canada Power System Outage Task Force. ...

  12. How the U.S. and Canada are Fighting Climate Change Together...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    U.S. and Canada are Fighting Climate Change Together How the U.S. and Canada are Fighting Climate Change Together March 10, 2016 - 4:57pm Addthis President Obama and Canadian Prime ...

  13. ,"Price of U.S. Natural Gas Pipeline Imports From Canada (Dollars...

    Energy Information Administration (EIA) (indexed site)

    Gas Pipeline Imports From Canada (Dollars per Thousand Cubic Feet)" "Sourcekey","N9102CN3" "Date","Price of U.S. Natural Gas Pipeline Imports From Canada (Dollars per Thousand ...

  14. ,"Compressed U.S. Natural Gas Imports from Canada (Million Cubic...

    Energy Information Administration (EIA) (indexed site)

    Natural Gas Imports from Canada (Million Cubic Feet)" "Sourcekey","NGMEPG0INCNUS-NCAMMCF" "Date","Compressed U.S. Natural Gas Imports from Canada (Million Cubic Feet)" ...

  15. ,"Compressed U.S. Natural Gas Exports to Canada (Million Cubic...

    Energy Information Administration (EIA) (indexed site)

    U.S. Natural Gas Exports to Canada (Million Cubic Feet)" "Sourcekey","NGMEPG0ENCNUS-NCAMMCF" "Date","Compressed U.S. Natural Gas Exports to Canada (Million Cubic Feet)" ...

  16. ,"Price of U.S. Liquefied Natural Gas Imports From Canada (Dollars...

    Energy Information Administration (EIA) (indexed site)

    Gas Imports From Canada (Dollars per Thousand Cubic Feet)" "Sourcekey","NGMEPG0NUS-NCAPMLDMCF" "Date","Price of U.S. Liquefied Natural Gas Imports From Canada (Dollars per ...

  17. Price of Champlain, NY Natural Gas LNG Imports from Canada (Dollars...

    Gasoline and Diesel Fuel Update

    from Canada (Dollars per Thousand Cubic Feet) Price of Champlain, NY Natural Gas LNG Imports from Canada (Dollars per Thousand Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep...

  18. Canada and the United States Cooperate to Shut Down One of the...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Canada and the United States Cooperate to Shut Down One of the Last Weapons-Grade Plutonium Production Reactors in Russia Canada and the United States Cooperate to Shut Down One of ...

  19. U.S.-Canada Clean Energy Dialogue (CED) Second Report to Leaders...

    Energy.gov [DOE] (indexed site)

    Report to the President of the United States of America and the Prime Minister of Canada U.S.-Canada Clean Energy Dialogue Second Report to Leaders More Documents & Publications...

  20. U.S.-Canada Clean Energy Dialogue (CED) Report to Leaders | Department...

    Office of Environmental Management (EM)

    Report to Leaders U.S.-Canada Clean Energy Dialogue (CED) Report to Leaders First Report to the Prime Minister of Canada and the President of the United States of America PDF icon...

  1. Price of Liquefied U.S. Natural Gas Exports by Truck to Canada...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Canada (Dollars per Thousand Cubic Feet) Price of Liquefied U.S. Natural Gas Exports by Truck to Canada (Dollars per Thousand Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep...

  2. Price of Babb, MT Liquefied Natural Gas Exports to Canada (Dollars...

    Annual Energy Outlook

    Babb, MT Liquefied Natural Gas Exports to Canada (Dollars per Thousand Cubic Feet) Price of Babb, MT Liquefied Natural Gas Exports to Canada (Dollars per Thousand Cubic Feet) Year...

  3. Liquefied U.S. Natural Gas Exports by Truck to Canada (Million...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Canada (Million Cubic Feet) Liquefied U.S. Natural Gas Exports by Truck to Canada (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2007 2 2008 0 0 0 0 0 0...

  4. Price of Compressed U.S. Natural Gas Exports to Canada (Dollars...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    to Canada (Dollars per Thousand Cubic Feet) Price of Compressed U.S. Natural Gas Exports to Canada (Dollars per Thousand Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct...

  5. U.S. and Canada Sign Statement of Intent on Nuclear Cleanup

    Energy.gov [DOE]

    DOE and the Atomic Energy of Canada Limited (AECL) signed a Statement of Intent (SOI) at the Waste Management Conference.

  6. SEP and ISO 50001 at 3M Canada's Brockville Plant | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    and ISO 50001 at 3M Canada's Brockville Plant SEP and ISO 50001 at 3M Canada's Brockville Plant Superior Energy Performance logo This presentation by 3M Canada discusses their successes implementing an ISO 50001 Energy Management System and participating in the Superior Energy Performance® (SEP(tm)) program at their Brockville, Ontario Tape Manufacturing facility. SEP and ISO 50001 at 3M Canada's Brockville Plant, 2014 (2.54 MB) More Documents & Publications Energy Efficiency: A Competitive

  7. Application to Export Electric Energy OE Docket No. EA-297-B SESCO Enterprises, Canada Ltd: Federal Register Notice Volume 76, No. 41- Mar. 2, 2011

    Energy.gov [DOE]

    Application from SESCO Enterprises, Canada Ltd to export electric energy to Canada. Federal Register Notice Vol 76 No 41

  8. MiR-153 inhibits migration and invasion of human non-small-cell lung cancer by targeting ADAM19

    SciTech Connect

    Shan, Nianxi; Shen, Liangfang; Wang, Jun; He, Dan; Duan, Chaojun

    2015-01-02

    Highlights: • Decreased miR-153 and up-regulated ADAM19 are correlated with NSCLC pathology. • MiR-153 inhibits the proliferation and migration and invasion of NSCLC cells in vitro. • ADAM19 is a direct target of miR-153. • ADAM19 is involved in miR-153-suppressed migration and invasion of NSCLC cells. - Abstract: MiR-153 was reported to be dysregulated in some human cancers. However, the function and mechanism of miR-153 in lung cancer cells remains unknown. In this study, we investigated the role of miR-153 in human non-small-cell lung cancer (NSCLC). Using qRT-PCR, we demonstrated that miR-153 was significantly decreased in clinical NSCLC tissues and cell lines, and downregulation of miR-153 was significantly correlated with lymph node status. We further found that ectopic expression of miR-153 significantly inhibited the proliferation and migration and invasion of NSCLC cells in vitro, suggesting that miR-153 may be a novel tumor suppressor in NSCLC. Further integrated analysis revealed that ADAM19 is as a direct and functional target of miR-153. Luciferase reporter assay demonstrated that miR-153 directly targeted 3′UTR of ADAM19, and correlation analysis revealed an inverse correlation between miR-153 and ADAM19 mRNA levels in clinical NSCLC tissues. Knockdown of ADAM19 inhibited migration and invasion of NSCLC cells which was similar with effects of overexpression of miR-153, while overexpression of ADAM19 attenuated the function of miR-153 in NSCLC cells. Taken together, our results highlight the significance of miR-153 and ADAM19 in the development and progression of NSCLC.

  9. miR-129 suppresses tumor cell growth and invasion by targeting PAK5 in hepatocellular carcinoma

    SciTech Connect

    Zhai, Jian; Qu, Shuping; Li, Xiaowei; Zhong, Jiaming; Chen, Xiaoxia; Qu, Zengqiang; Wu, Dong

    2015-08-14

    Emerging evidence suggests that microRNAs (miRNAs) play important roles in regulating HCC development and progression; however, the mechanisms by which their specific functions and mechanisms remained to be further explored. miR-129 has been reported in gastric cancers, lung cancer and colon cancer. In this study, we disclosed a new tumor suppresser function of miR-129 in HCC. We also found the downregulation of miR-129 occurred in nearly 3/4 of the tumors examined (56/76) compared with adjacent nontumorous tissues, which was more importantly, correlated to the advanced stage and vascular invasion. We then demonstrated that miR-129 overexpression attenuated HCC cells proliferation and invasion, inducing apoptosis in vitro. Moreover, we used miR-129 antagonist and found that anti-miR-129 promoted HCC cells malignant phenotypes. Mechanistically, our further investigations revealed that miR-129 suppressed cell proliferation and invasion by targeting the 3’-untranslated region of PAK5, as well as miR-129 silencing up-regulated PAK5 expression. Moreover, miR-129 expression was inversely correlated with PAK5 expression in 76 cases of HCC samples. RNA interference of PAK5 attenuated anti-miR-129 mediated cell proliferation and invasion in HCC cells. Taken together, these results demonstrated that miR-129 suppressed tumorigenesis and progression by directly targeting PAK5, defining miR-129 as a potential treatment target for HCC. - Highlights: • Decreased of miR-129 is found in HCC and associated with advanced stage and metastasis. • miR-129 suppresses proliferation and invasion of HCC cells. • miR-129 directly targets the 3′ UTR of PAK5 and diminishes PAK5 expression. • PAK5 is involved in miR-129 mediated suppression functions.

  10. Transcriptional regulation of miR-146b by C/EBPβ LAP2 in esophageal cancer cells

    SciTech Connect

    Li, Junxia; Shan, Fabo; Xiong, Gang; Wang, Ju-Ming; Wang, Wen-Lin; Xu, Xueqing; Bai, Yun

    2014-03-28

    Highlights: • MiR-146b promotes esophageal cancer cell proliferation. • MiR-146b inhibits esophageal cancer cell apoptosis. • C/EBPβ directly binds to miR-146b promoter conserved region. • MiR-146b is up-regulated by C/EBPβ LAP2 transcriptional activation. - Abstract: Recent clinical study indicated that up-regulation of miR-146b was associated with poor overall survival of patients in esophageal squamous cell carcinoma. However, the underlying mechanism of miR-146b dysregulation remains to be explored. Here we report that miR-146b promotes cell proliferation and inhibits cell apoptosis in esophageal cancer cell lines. Mechanismly, two C/EBPβ binding motifs are located in the miR-146b promoter conserved region. Among the three isoforms of C/EBPβ, C/EBPβ LAP2 positively regulated miR-146b expression and increases miR-146b levels in a dose-dependent manner through transcription activation of miR-146b gene. Together, these results suggest a miR-146b regulatory mechanism involving C/EBPβ, which may contribute to the up-regulation of miR-146b in esophageal squamous cell carcinoma.

  11. miR-1297 mediates PTEN expression and contributes to cell progression in LSCC

    SciTech Connect

    Li, Xin; Wang, Hong-liang; Peng, Xin; Zhou, Hui-fang; Wang, Xin

    2012-10-19

    Highlights: Black-Right-Pointing-Pointer miR-1297 was found to be overexpressed in LSCC and contribute to the cell progression. Black-Right-Pointing-Pointer PTEN was confirmed to be a target gene of miR-1297. Black-Right-Pointing-Pointer Downregulation of PTEN can rescue the proliferation and invasion ability of miR-1297 downregulated Hep-2 cells. Black-Right-Pointing-Pointer Downregulation of miR-1297 inhibits tumor growth in vivo. -- Abstract: MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression after transcription, and are involved in cancer development. Laryngeal squamous cell carcinoma (LSCC) is one of the most common malignant neoplasms with increasing incidence in recent years. In this paper, we report the overexpression of miR-1297 in LSCC and Hep-2 cells. In addition, PTEN was identified to be directly regulated by miR-1297 through western blot and luciferase activity assay. Furthermore, downregulation of miR-1297 in Hep-2 cells was shown to inhibit cancer cell proliferation, migration, and tumor genesis. Our results document a new epigenetic mechanism for PTEN regulation in LSCC, which is crucial for the development of these tumors.

  12. miR-30a suppresses breast cancer cell proliferation and migration by targeting Eya2

    SciTech Connect

    Fu, Jing; Xu, Xiaojie; Kang, Lei; Zhou, Liying; Wang, Shibin; Lu, Juming; Cheng, Long; Fan, Zhongyi; Yuan, Bin; Tian, Peirong; Zheng, Xiaofei; Yu, Chengze; Ye, Qinong; Lv, Zhaohui

    2014-03-07

    Highlights: • miR-30a represses Eya2 expression by binding to the 3′-untranslated region of Eya2. • The miR-30a/EYA2 axis regulates breast cancer cell proliferation and migration. • The miR-30a/EYA2 axis modulates G1/S cell cycle progression. • The miR-30a/EYA2 axis is dysregulated in breast cancer patients. - Abstract: Eye absent (Eya) proteins are involved in cell fate determination in a broad spectrum of cells and tissues. Aberrant expression of Eya2 has been documented in a variety of cancers and correlates with clinical outcome. However, whether microRNAs (miRNAs) can regulate Eya2 expression remains unknown. Here, we show that miR-30a represses Eya2 expression by binding to the 3′-untranslated region of Eya2. Overexpression of Eya2 in miR-30a-transfected breast cancer cells effectively rescued the inhibition of cell proliferation and migration caused by miR-30a. Knockdown of Eya2 by small-interfering RNA (siRNA) in breast cancer cells mimicked the effect induced by miR-30a and abolished the ability of miR-30a to regulate breast cancer cell proliferation and migration. The miR-30a/Eya2 axis could regulate G1/S cell cycle progression, accompanied by the modulation of expression of cell cycle-related proteins, including cyclin A, cyclin D1, cyclin E, and c-Myc. Moreover, miR-30a expression was downregulated in breast cancer patients, and negatively correlated with Eya2, which was upregulated in breast cancer patients. These data suggest that the miR-30a/Eya2 axis may play an important role in breast cancer development and progression and that miR-30a activation or Eya2 inhibition may be a useful strategy for cancer treatment.

  13. U.S.-Canada Clean Energy Dialogue (CED) Action Plan II | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energy U.S.-Canada Clean Energy Dialogue (CED) Action Plan II U.S.-Canada Clean Energy Dialogue (CED) Action Plan II The U.S. Department of Energy (DOE) and Environment Canada released the U.S.-Canada Clean Energy Dialogue (CED) Action Plan II, outlining the next phase of activities the two countries will undertake to jointly advance clean energy technologies. CED Action Plan II_June 12 2012.pdf (618.5 KB) More Documents & Publications U.S.-Canada Clean Energy Dialogue (CED) Action Plan

  14. miR-21 modulates resistance of HR-HPV positive cervical cancer cells to radiation through targeting LATS1

    SciTech Connect

    Liu, Shikai; Song, Lili Zhang, Liang; Zeng, Saitian; Gao, Fangyuan

    2015-04-17

    Although multiple miRNAs are found involved in radioresistance development in HR-HPV positive (+) cervical cancer, only limited studies explored the regulative mechanism of the miRNAs. miR-21 is one of the miRNAs significantly upregulated in HR-HPV (+) cervical cancer is also significantly associated with radioresistance. However, the detailed regulative network of miR-21 in radioresistance is still not clear. In this study, we confirmed that miR-21 overexpression was associated with higher level of radioresistance in HR-HPV (+) cervical cancer patients and thus decided to further explore its role. Findings of this study found miR-21 can negatively affect radiosensitivity of HR-HPV (+) cervical cancer cells and decrease radiation induced G2/M block and increase S phase accumulation. By using dual luciferase assay, we verified a binding site between miR-21 and 3′-UTR of large tumor suppressor kinase 1 (LATS1). Through direct binding, miR-21 can regulate LATS1 expression in cervical cancer cells. LATS1 overexpression can reverse miR-21 induced higher colony formation rate and also reduced miR-21 induced S phase accumulation and G2/M phase block reduction under radiation treatment. These results suggested that miR-21-LATS1 axis plays an important role in regulating radiosensitivity. - Highlights: • miR-21 is highly expressed in HR-HPV (+) radioresistant cervical cancer patients. • miR-21 can negatively affect radiosensitivity of HR-HPV (+) cervical cancer cells. • miR-21 can decrease radiation induced G2/M block and increase S phase accumulation. • miR-21 modulates radiosensitivity cervical cancer cell by directly targeting LATS1.

  15. miR-92a is upregulated in cervical cancer and promotes cell proliferation and invasion by targeting FBXW7

    SciTech Connect

    Zhou, Chuanyi; Shen, Liangfang; Mao, Lei; Wang, Bing; Li, Yang; Yu, Huizhi

    2015-02-27

    MicroRNAs (miRNAs) are involved in the cervical carcinogenesis and progression. In this study, we investigated the role of miR-92a in progression and invasion of cervical cancer. MiR-92a was significantly upregulated in cervical cancer tissues and cell lines. Overexpression of miR-92a led to remarkably enhanced proliferation by promoting cell cycle transition from G1 to S phase and significantly enhanced invasion of cervical cancer cells, while its knockdown significantly reversed these cellular events. Bioinformatics analysis suggested F-box and WD repeat domain-containing 7 (FBXW7) as a novel target of miR-92a, and miR-92a suppressed the expression level of FBXW7 mRNA by direct binding to its 3′-untranslated region (3′UTR). Expression of miR-92a was negatively correlated with FBXW7 in cervical cancer tissues. Furthermore, Silencing of FBXW7 counteracted the effects of miR-92a suppression, while its overexpression reversed oncogenic effects of miR-92a. Together, these findings indicate that miR-92a acts as an onco-miRNA and may contribute to the progression and invasion of cervical cancer, suggesting miR-92a as a potential novel diagnostic and therapeutic target of cervical cancer. - Highlights: • miR-92a is elevated in cervical cancer tissues and cell lines. • miR-92a promotes cervical cancer cell proliferation, cell cycle transition from G1 to S phase and invasion. • FBXW7 is a direct target of miR-92a. • FBXW7 counteracts the oncogenic effects of miR-92a on cervical cancer cells.

  16. NuMI proton kicker extraction magnet termination resistor system

    SciTech Connect

    Reeves, S.R.; Jensen, C.C.; /Fermilab

    2005-05-01

    The temperature stability of the kicker magnet termination resistor assembly directly affects the field flatness and amplitude stability. Comprehensive thermal enhancements were made to the existing Main Injector resistor assembly design to satisfy NuMI performance specifications. Additionally, a fluid-processing system utilizing Fluorinert{reg_sign} FC-77 high-voltage dielectric was built to precisely control the setpoint temperature of the resistor assembly from 70 to 120F, required to maintain constant resistance during changing operational modes. The Fluorinert{reg_sign} must be continually processed to remove hazardous breakdown products caused by radiation exposure to prevent chemical attack of system components. Design details of the termination resistor assembly and Fluorinert{reg_sign} processing system are described. Early performance results will be presented.

  17. Non-canonical microRNAs miR-320 and miR-702 promote proliferation in Dgcr8-deficient embryonic stem cells

    SciTech Connect

    Kim, Byeong-Moo; Choi, Michael Y.

    2012-09-21

    Highlights: Black-Right-Pointing-Pointer Embryonic stem cells (ESCs) lacking non-canonical miRNAs proliferate slower. Black-Right-Pointing-Pointer miR-320 and miR-702 are two non-canonical miRNAs expressed in ESCs. Black-Right-Pointing-Pointer miR-320 and miR-702 promote proliferation of Dgcr8-deficient ESCs. Black-Right-Pointing-Pointer miR-320 targets p57 and helps to release Dgcr8-deficient ESCs from G1 arrest. Black-Right-Pointing-Pointer miR-702 targets p21 and helps to release Dgcr8-deficient ESCs from G1 arrest. -- Abstract: MicroRNAs are known to contribute significantly to stem cell phenotype by post-transcriptionally regulating gene expression. Most of our knowledge of microRNAs comes from the study of canonical microRNAs that require two sequential cleavages by the Drosha/Dgcr8 heterodimer and Dicer to generate mature products. In contrast, non-canonical microRNAs bypass the cleavage by the Drosha/Dgcr8 heterodimer within the nucleus but still require cytoplasmic cleavage by Dicer. The function of non-canonical microRNAs in embryonic stem cells (ESCs) remains obscure. It has been hypothesized that non-canonical microRNAs have important roles in ESCs based upon the phenotypes of ESC lines that lack these specific classes of microRNAs; Dicer-deficient ESCs lacking both canonical and non-canonical microRNAs have much more severe proliferation defect than Dgcr8-deficient ESCs lacking only canonical microRNAs. Using these cell lines, we identified two non-canonical microRNAs, miR-320 and miR-702, that promote proliferation of Dgcr8-deficient ESCs by releasing them from G1 arrest. This is accomplished by targeting the 3 Prime -untranslated regions of the cell cycle inhibitors p57 and p21 and thereby inhibiting their expression. This is the first report of the crucial role of non-canonical microRNAs in ESCs.

  18. miR-182 targets CHL1 and controls tumor growth and invasion in papillary thyroid carcinoma

    SciTech Connect

    Zhu, Hongling; Fang, Jin; Zhang, Jichen; Zhao, Zefei; Liu, Lianyong; Wang, Jingnan; Xi, Qian; Gu, Mingjun

    2014-07-18

    Highlights: miR-182 and CHL1 expression patterns are negatively correlated. CHL1 is a direct target of miR-182 in PTC cells. miR-182 suppression inhibits PTC cell growth and invasion. CHL1 is involved in miR-182-mediated cell behavior. - Abstract: In this study, we investigated the role and underlying mechanism of action of miR-182 in papillary thyroid carcinoma (PTC). Bioinformatics analysis revealed close homolog of LI (CHL1) as a potential target of miR-182. Upregulation of miR-182 was significantly correlated with CHL1 downregulation in human PTC tissues and cell lines. miR-182 suppressed the expression of CHL1 mRNA through direct targeting of the 3?-untranslated region (3?-UTR). Downregulation of miR-182 suppressed growth and invasion of PTC cells. Silencing of CHL1 counteracted the effects of miR-182 suppression, while its overexpression mimicked these effects. Our data collectively indicate that miR-182 in PTC promotes cell proliferation and invasion through direct suppression of CHL1, supporting the potential utility of miR-182 inhibition as a novel therapeutic strategy against PTC.

  19. Downregulation of miRNA-30c and miR-203a is associated with hepatitis C virus core protein-induced epithelial–mesenchymal transition in normal hepatocytes and hepatocellular carcinoma cells

    SciTech Connect

    Liu, Dongjing; Wu, Jilin; Liu, Meizhou; Yin, Hui; He, Jiantai; Zhang, Bo

    2015-09-04

    Hepatitis C virus (HCV) Core protein has been demonstrated to induce epithelial–mesenchymal transition (EMT) and is associated with cancer progression of hepatocellular carcinoma (HCC). However, how the Core protein regulates EMT is still unclear. In this study, HCV Core protein was overexpressed by an adenovirus. The protein levels of EMT markers were measured by Western blot. The xenograft animal model was established by inoculation of HepG2 cells. Results showed that ectopic expression of HCV core protein induced EMT in L02 hepatocytes and HepG2 tumor cells by upregulating vimentin, Sanl1, and Snal2 expression and downregulating E-cadherin expression. Moreover, Core protein downregulated miR-30c and miR-203a levels in L02 and HepG2 cells, but artificial expression of miR-30c and miR-203a reversed Core protein-induced EMT. Further analysis showed that ectopic expression of HCV core protein stimulated cell proliferation, inhibited apoptosis, and increased cell migration, whereas artificial expression of miR-30c and miR-203a significantly reversed the role of Core protein in these cell functions in L02 and HepG2 cells. In the HepG2 xenograft tumor models, artificial expression of miR-30c and miR-203a inhibited EMT and tumor growth. Moreover, L02 cells overexpressing Core protein can form tumors in nude mice. In HCC patients, HCV infection significantly shortened patients' survival time, and loss of miR-30c and miR-203 expression correlated with poor survival. In conclusion, HCV core protein downregulates miR-30c and miR-203a expression, which results in activation of EMT in normal hepatocytes and HCC tumor cells. The Core protein-activated-EMT is involved in the carcinogenesis and progression of HCC. Loss of miR-30c and miR-203a expression is a marker for the poor prognosis of HCC. - Highlights: • HCV core protein downregulates miR-30c and miR-203a expression. • Downregulation of miR-30c and miR-203a activates EMT. • Activated-EMT is involved in the

  20. Warroad, MN Natural Gas Pipeline Exports (Price) Canada (Dollars per

    Energy Information Administration (EIA) (indexed site)

    Thousand Cubic Feet) (Price) Canada (Dollars per Thousand Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's NA 2000's NA NA NA - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Price of

  1. miR-128 and its target genes in tumorigenesis and metastasis

    SciTech Connect

    Li, Molin, E-mail: molin_li@hotmail.com [Dalian Medical University, Dalian 116044 (China); Fu, Weiming [Center for Food Safety and Environmental Technology, Guangzhou Institute of Advanced Technology, Chinese Academy of Sciences, Guangzhou 511458 (China); Wo, Lulu; Shu, Xiaohong [Dalian Medical University, Dalian 116044 (China); Liu, Fang [The second affiliated hospital of Dalian Medical University, Dalian 116023 (China); Li, Chuangang, E-mail: li_chuangang@sina.com [The second affiliated hospital of Dalian Medical University, Dalian 116023 (China)

    2013-12-10

    MicroRNAs (miRNAs) are a class of endogenous, non-coding, 1824 nucleotide length single-strand RNAs that could modulate gene expression at post-transcriptional level. Previous studies have shown that miR-128 enriched in the brain plays an important role in the development of nervous system and the maintenance of normal physical functions. Aberrant expression of miR-128 has been detected in many types of human tumors and its validated target genes are involved in cancer-related biological processes such as cell proliferation, differentiation and apoptosis. In this review, we will summarize the roles of miR-128 and its target genes in tumorigenesis and metastasis. - Highlights: Aberrant expression of miR-128 can be observed in many kinds of malignant tumors. The molecular mechanisms regulating miR-128 expression are elucidated. Roles of miR-128 and its target genes in tumorigenesis and metastasis are summarized.

  2. miR-125b inhibits osteoblastic differentiation by down-regulation of cell proliferation

    SciTech Connect

    Mizuno, Yosuke; Yagi, Ken; Tokuzawa, Yoshimi; Kanesaki-Yatsuka, Yukiko; Suda, Tatsuo; Katagiri, Takenobu; Fukuda, Toru; Maruyama, Masayoshi; Okuda, Akihiko; Amemiya, Tomoyuki; Kondoh, Yasumitsu; Tashiro, Hideo; Okazaki, Yasushi

    2008-04-04

    Although various microRNAs regulate cell differentiation and proliferation, no miRNA has been reported so far to play an important role in the regulation of osteoblast differentiation. Here we describe the role of miR-125b in osteoblastic differentiation in mouse mesenchymal stem cells, ST2, by regulating cell proliferation. The expression of miR-125b was time-dependently increased in ST2 cells, and the increase in miR-125b expression was attenuated in osteoblastic-differentiated ST2 cells induced by BMP-4. The transfection of exogenous miR-125b inhibited proliferation of ST2 cells and caused inhibition of osteoblastic differentiation. In contrast, when the endogenous miR-125b was blocked by transfection of its antisense RNA molecule, alkaline phosphatase activity after BMP-4 treatment was elevated. These results strongly suggest that miR-125b is involved in osteoblastic differentiation through the regulation of cell proliferation.

  3. Electricity transactions across international borders, 1985. [With Mexico, Canada

    SciTech Connect

    Not Available

    1986-10-01

    This report summarizes the electricity exchange between the United States and Mexico and Canada during Calendar Year 1985. The construction, opration and maintenance of any electric transmission facility which crosses an international border of the United States requires a Presidential permit which has been granted by DOE. During 1985, the US imported 45,900,563 MWh of electric energy at a cost of $1,041,908,785. Of this total, 45,659,944 MWh were imported from Canada and the remainder (240,619 MWh) were received from Mexico. During this same period, US exports of electric energy totaled 4,964,930 MWh with gross revenues of $25,215,549. Of this, 4,812,537 MWh representing $22,068,665 in revenues were delivered to Canada, and 152,393 MWh representing $3,146,884 in revenues were delivered to Mexico. On a net basis, the US was an importer of 40,935,633 MWh of electric energy. These 1985 values constitute an increase of 8.1% in gross imports and an increase of 94.1% in gross exports compared to 1984 levels.

  4. miR-15a/16 Enhances Radiation Sensitivity of Non-Small Cell Lung Cancer

    Office of Scientific and Technical Information (OSTI)

    Cells by Targeting the TLR1/NF-κB Signaling Pathway (Journal Article) | SciTech Connect miR-15a/16 Enhances Radiation Sensitivity of Non-Small Cell Lung Cancer Cells by Targeting the TLR1/NF-κB Signaling Pathway Citation Details In-Document Search Title: miR-15a/16 Enhances Radiation Sensitivity of Non-Small Cell Lung Cancer Cells by Targeting the TLR1/NF-κB Signaling Pathway Purpose: Many miRNAs have been identified as essential issues and core determining factors in tumor radiation.

  5. Overexpression of miR-206 suppresses glycolysis, proliferation and migration in breast cancer cells via PFKFB3 targeting

    SciTech Connect

    Ge, Xin; Lyu, Pengwei; Cao, Zhang; Li, Jingruo; Guo, Guangcheng; Xia, Wanjun; Gu, Yuanting

    2015-08-07

    miRNAs, sorting as non-coding RNAs, are differentially expressed in breast tumor and act as tumor promoters or suppressors. miR-206 could suppress the progression of breast cancer, the mechanism of which remains unclear. The study here was aimed to investigate the effect of miR-206 on human breast cancers. We found that miR-206 was down-regulated while one of its predicted targets, 6-Phosphofructo-2-kinase (PFKFB3) was up-regulated in human breast carcinomas. 17β-estradiol dose-dependently decreased miR-206 expression as well as enhanced PFKFB3 mRNA and protein expression in estrogen receptor α (ERα) positive breast cancer cells. Furthermore, we identified that miR-206 directly interacted with 3′-untranslated region (UTR) of PFKFB3 mRNA. miR-206 modulated PFKFB3 expression in MCF-7, T47D and SUM159 cells, which was influenced by 17β-estradiol depending on ERα expression. In addition, miR-206 overexpression impeded fructose-2,6-bisphosphate (F2,6BP) production, diminished lactate generation and reduced cell proliferation and migration in breast cancer cells. In conclusion, our study demonstrated that miR-206 regulated PFKFB3 expression in breast cancer cells, thereby stunting glycolysis, cell proliferation and migration. - Highlights: • miR-206 was down-regulated and PFKFB3 was up-regulated in human breast carcinomas. • 17β-estradiol regulated miR-206 and PFKFB3 expression in ERα+ cancer cells. • miR-206directly interacted with 3′-UTR of PFKFB3 mRNA. • miR-206 fructose-2,6-bisphosphate (F2,6BP) impeded production and lactate generation. • miR-206 reduced cell proliferation and migration in breast cancer cells.

  6. AMENDMENT OF SOLICITATION/MODIFICATlON OF CONTRACT MI54 I See...

    National Nuclear Security Administration (NNSA)

    MI54 I See Block 16C I REQ. NO. Babcock & Wilcox Technical Services Pantex, LLC PO Box 30020 Amarillo, TX 79120 2. AMENDMENTIMODIFICATION NO. 1 3. EFFECTIVE DATE 1 4. ...

  7. File:USDA-CE-Production-GIFmaps-MI.pdf | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    MI.pdf Jump to: navigation, search File File history File usage Michigan Ethanol Plant Locations Size of this preview: 463 599 pixels. Other resolution: 464 600 pixels. Full...

  8. Simulations of neutron multiplicity measurements with MCNP-PoliMi.

    SciTech Connect

    Mattingly, John K.; Pozzi, Sara A.; Clarke, Shaun D.; Dennis, Ben D.; Miller, Eric C.

    2010-09-01

    The heightened focus on nuclear safeguards and accountability has increased the need to develop and verify simulation tools for modeling these applications. The ability to accurately simulate safeguards techniques, such as neutron multiplicity counting, aids in the design and development of future systems. This work focuses on validating the ability of the Monte Carlo code MCNPX-PoliMi to reproduce measured neutron multiplicity results for a highly multiplicative sample. The benchmark experiment for this validation consists of a 4.5-kg sphere of plutonium metal that was moderated by various thicknesses of polyethylene. The detector system was the nPod, which contains a bank of 15 3He detectors. Simulations of the experiments were compared to the actual measurements and several sources of potential bias in the simulation were evaluated. The analysis included the effects of detector dead time, source-detector distance, density, and adjustments made to the value of {nu}-bar in the data libraries. Based on this analysis it was observed that a 1.14% decrease in the evaluated value of {nu}-bar for 239Pu in the ENDF-VII library substantially improved the accuracy of the simulation.

  9. Climate Action Champions: Sault Ste. Marie Tribe of Chippewa Indians, MI |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Sault Ste. Marie Tribe of Chippewa Indians, MI Climate Action Champions: Sault Ste. Marie Tribe of Chippewa Indians, MI The Sault Ste. Marie Tribe of Chippewa Indians is a 44,000-strong federally recognized Indian tribe that is an economic, social and cultural force in its community across the eastern Upper Peninsula counties of Chippewa, Luce, Mackinac, Schoolcraft, Alger, Delta and Marquette, with housing and tribal centers, casinos, and other enterprises that employ

  10. BC Hydro Brings Energy Savings to Low-Income Families in Canada |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy BC Hydro Brings Energy Savings to Low-Income Families in Canada BC Hydro Brings Energy Savings to Low-Income Families in Canada The number of British Columbia, Canada, households eligible for Better Buildings Residential Network member BC Hydro's Energy Conservation Assistance Program (ECAP) just doubled. British Columbia Energy Minister Bill Bennett recently announced an increase in the low-income qualification cutoff for BC Hydro's free home energy-saving kits and

  11. Canada, Mexico and the United States Show Progress on North American Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Collaboration | Department of Energy Canada, Mexico and the United States Show Progress on North American Energy Collaboration Canada, Mexico and the United States Show Progress on North American Energy Collaboration June 3, 2016 - 3:48pm Addthis Canada, Mexico and the United States Show Progress on North American Energy Collaboration News Media Contact (202) 586-4940 DOENews@hq.doe.gov SAN FRANCISCO, Calif. - In support of the objectives of the 7th Clean Energy Ministerial (CEM) and

  12. Guide to Federal Regulation of Sales of Imported Electricity in Canada,

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Mexico and the United States | Department of Energy Federal Regulation of Sales of Imported Electricity in Canada, Mexico and the United States Guide to Federal Regulation of Sales of Imported Electricity in Canada, Mexico and the United States A Publication of The North American Energy Working Group on January 2005 Guide to Federal Regulation of Sales of Imported Electricity in Canada, Mexico and the United States (155.3 KB) More Documents & Publications North America: Regulation of

  13. U.S.-Canada Clean Energy Dialogue (CED) | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Canada Clean Energy Dialogue (CED) U.S.-Canada Clean Energy Dialogue (CED) Photo by White House/Pete Souza. Photo by White House/Pete Souza. President Obama and Prime Minister Harper launched the U.S.-Canada Clean Energy Dialogue (CED) in February 2009 to encourage the development of clean energy technologies to reduce greenhouse gases and combat climate change in both countries. The CED is charged with: expanding clean energy research and development; developing and deploying clean energy

  14. U.S. and Canada Sign Agreement to Enhance Collaboration in Civilian Nuclear

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energy Research and Development | Department of Energy U.S. and Canada Sign Agreement to Enhance Collaboration in Civilian Nuclear Energy Research and Development U.S. and Canada Sign Agreement to Enhance Collaboration in Civilian Nuclear Energy Research and Development January 13, 2015 - 5:12pm Addthis U.S. and Canada Sign Agreement to Enhance Collaboration in Civilian Nuclear Energy Research and Development Maisah Khan Maisah Khan Special Advisor, Office of International Affairs Joint

  15. U.S., Canada, and Finland Pyrolysis Collaborations | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    , Canada, and Finland Pyrolysis Collaborations U.S., Canada, and Finland Pyrolysis Collaborations Jonathan Male, PNNL, presentation at the December 5, 2012, Biomass Program-hosted International webinar on U.S., Canada, and Finland pyrolysis collaborations. male_2012_webinar.pdf (837.26 KB) More Documents & Publications Conversion Technologies for Advanced Biofuels - Bio-Oil Upgrading 2013 Peer Review Presentations-Bio-oil Bioenergy Technologies Office R&D Pathways: Fast Pyrolysis and

  16. Algae Biofuels Co-Location Assessment Tool for Canada

    Energy Science and Technology Software Center

    2011-11-29

    The Algae Biofuels Co-Location Assessment Tool for Canada uses chemical stoichiometry to estimate Nitrogen, Phosphorous, and Carbon atom availability from waste water and carbon dioxide emissions streams, and requirements for those same elements to produce a unit of algae. This information is then combined to find limiting nutrient information and estimate potential productivity associated with waste water and carbon dioxide sources. Output is visualized in terms of distributions or spatial locations. Distances are calculated betweenmore » points of interest in the model using the great circle distance equation, and the smallest distances found by an exhaustive search and sort algorithm.« less

  17. Algae Biofuels Co-Location Assessment Tool for Canada

    SciTech Connect

    2011-11-29

    The Algae Biofuels Co-Location Assessment Tool for Canada uses chemical stoichiometry to estimate Nitrogen, Phosphorous, and Carbon atom availability from waste water and carbon dioxide emissions streams, and requirements for those same elements to produce a unit of algae. This information is then combined to find limiting nutrient information and estimate potential productivity associated with waste water and carbon dioxide sources. Output is visualized in terms of distributions or spatial locations. Distances are calculated between points of interest in the model using the great circle distance equation, and the smallest distances found by an exhaustive search and sort algorithm.

  18. International Falls, MN Natural Gas Pipeline Imports From Canada (Dollars

    Energy Information Administration (EIA) (indexed site)

    per Thousand Cubic Feet) Dollars per Thousand Cubic Feet) International Falls, MN Natural Gas Pipeline Imports From Canada (Dollars per Thousand Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 1.71 2.03 2.00 2.33 2000's 2.77 4.85 3.01 -- -- 11.20 -- - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages:

  19. Midwest Region Alternative Fuels Project

    Office of Energy Efficiency and Renewable Energy (EERE)

    2011 DOE Hydrogen and Fuel Cells Program, and Vehicle Technologies Program Annual Merit Review and Peer Evaluation

  20. Midwest Region Alternative Fuels Project

    Office of Energy Efficiency and Renewable Energy (EERE)

    2010 DOE Vehicle Technologies and Hydrogen Programs Annual Merit Review and Peer Evaluation Meeting, June 7-11, 2010 -- Washington D.C.

  1. Transmission Expansion in the Midwest

    Energy.gov [DOE]

    At this unique forum, participants will hear top executives from the area's RTOs, utilities, transmission developers, and state regulatory agencies discuss and debate the most critical issues...

  2. miR-196a targets netrin 4 and regulates cell proliferation and migration of cervical cancer cells

    SciTech Connect

    Zhang, Jie; Zheng, Fangxia; Yu, Gang; Yin, Yanhua; Lu, Qingyang

    2013-11-01

    Highlights: miR-196a was overexpressed in cervical cancer tissue compared to normal tissue. miR-196a expression elevated proliferation and migration of cervical cancer cells. miR-196a inhibited NTN4 expression by binding 3?-UTR region of NTN4 mRNA. NTN4 inversely correlated with miR-196a expression in cervical tissue and cell line. NTN4 expression was low in cervical cancer tissue compared to normal tissue. -- Abstract: Recent research has uncovered tumor-suppressive and oncogenic potential of miR-196a in various tumors. However, the expression and mechanism of its function in cervical cancer remains unclear. In this study, we assess relative expression of miR-196a in cervical premalignant lesions, cervical cancer tissues, and four cancer cell lines using quantitative real-time PCR. CaSki and HeLa cells were treated with miR-196a inhibitors, mimics, or pCDNA/miR-196a to investigate the role of miR-196a in cancer cell proliferation and migration. We demonstrated that miR-196a was overexpressed in cervical intraepithelial neoplasia 23 and cervical cancer tissue. Moreover, its expression contributes to the proliferation and migration of cervical cancer cells, whereas inhibiting its expression led to a reduction in proliferation and migration. Five candidate targets of miR-196a chosen by computational prediction and Cervical Cancer Gene Database search were measured for their mRNA in both miR-196a-overexpressing and -depleted cancer cells. Only netrin 4 (NTN4) expression displayed an inverse association with miR-196a. Fluorescent reporter assays revealed that miR-196a inhibited NTN4 expression by targeting one binding site in the 3?-untranslated region (3?-UTR) of NTN4 mRNA. Furthermore, qPCR and Western blot assays verified NTN4 expression was downregulated in cervical cancer tissues compared to normal controls, and in vivo mRNA level of NTN4 inversely correlated with miR-196a expression. In summary, our findings provide new insights about the functional role of

  3. Canada's energy picture: Prospects for renewable and nonrenewable energy sources

    SciTech Connect

    Dixon, R.S.

    1980-12-01

    Canada's historical energy consumption, its current consumption and its likely requirements by the turn of the century are reviewed. It is estimated that up to 50% more energy will be required in the year 2000 than is consumed now. Both non-renewable and renewable energy resources are reviewed in the light of these future energy requirements and the need to substitute alternative energy sources for conventional oil. Most of the increase in energy consumption and the substitution of oil are likely to be met by conventional energy sources, since their reserves are extensive and their technologies well-established. Use of these resources will help Canada to reduce and eventually eliminate its dependency on imported oil and achieve energy selfsufficiency in the future. It will also allow time to carefully assess nonconventional energy sources, the most successful of which could become a significant part of the energy picture in the next century. This use of established energy sources and the gradual development and incorporation of new energy sources will cause minimal disruption to society and will lay the foundation for a future society with its energy options secured.

  4. Twenty Years of Underground Research at Canada's URL

    SciTech Connect

    Chandler, N. A.

    2003-02-27

    Construction of Atomic Energy of Canada Limited's (AECL's) Underground Research Laboratory (URL) began in 1982. The URL was designed to address the needs of the Canadian nuclear fuel waste management program. Over the years, a comprehensive program of geologic characterization and underground hydrogeologic, geotechnical and geomechanical projects have been performed, many of which are ongoing. The scientific work at the URL has evolved through a number of different phases to meet the changing needs of Canada's waste management program. The various phases of the URL have included siting, site evaluation, construction and operation. Collaboration with international organizations is encouraged at the URL, with the facility being a centre of excellence in an International Atomic Energy Agency (IAEA) network of underground facilities. One of AECL's major achievements of the past 20 year program has been the preparation and public defense of a ten-volume Environmental Impact Statement (EIS) for a conceptual deep geologic repository. Completion of this dissertation on the characterization, construction and performance modeling of a conceptual repository in the granite rock of the Canadian Shield was largely based on work conducted at the URL. Work conducted over the seven years since public defense of the EIS has been directed towards developing those engineering and performance assessment tools that would be required for implementation of a deep geologic repository. The URL continues to be a very active facility with ongoing experiments and demonstrations performed for a variety of Canadian and international radioactive waste management organizations.

  5. Tritium handling experience at Atomic Energy of Canada Limited

    SciTech Connect

    Suppiah, S.; McCrimmon, K.; Lalonde, S.; Ryland, D.; Boniface, H.; Muirhead, C.; Castillo, I.

    2015-03-15

    Canada has been a leader in tritium handling technologies as a result of the successful CANDU reactor technology used for power production. Over the last 50 to 60 years, capabilities have been established in tritium handling and tritium management in CANDU stations, tritium removal processes for heavy and light water, tritium measurement and monitoring, and understanding the effects of tritium on the environment. This paper outlines details of tritium-related work currently being carried out at Atomic Energy of Canada Limited (AECL). It concerns the CECE (Combined Electrolysis and Catalytic Exchange) process for detritiation, tritium-compatible electrolysers, tritium permeation studies, and tritium powered batteries. It is worth noting that AECL offers a Tritium Safe-Handling Course to national and international participants, the course is a mixture of classroom sessions and hands-on practical exercises. The expertise and facilities available at AECL is ready to address technological needs of nuclear fusion and next-generation nuclear fission reactors related to tritium handling and related issues.

  6. Implementing Arrangement Between the U.S. Department of Energy and the Department of Natural Resources of Canada and Atomic Energy of Canada Limited For Collaboration in the Area of Nuclear Research

    Energy.gov [DOE]

    Implementing Arrangement Between the U.S. Department of Energy and the Department of Natural Resources of Canada and Atomic Energy of Canada Limited For Collaboration in the Area of Nuclear Research

  7. <mi>B> -meson decay constants from 2+1 -flavor lattice QCD with domain-wall light quarks and relativistic heavy quarks

    SciTech Connect

    Christ, N. H.; Flynn, J. M.; Izubuchi, T.; Kawanai, T.; Lehner, C.; Soni, A.; Van de Water, R. S.; Witzel, O.

    2015-03-01

    We calculate the mi>Bmi>-meson decay constants mi>fmi>mi>Bmi>, mi>fmi>mi>Bmi>mi>smi>, and their ratio in unquenched lattice QCD using domain-wall light quarks and relativistic mi>b> quarks. We use gauge-field ensembles generated by the RBC and UKQCD collaborations using the domain-wall fermion action and Iwasaki gauge action with three flavors of light dynamical quarks. We analyze data at two lattice spacings of mi>ami>0.11, 0.086 fm with unitary pion masses as light as mi>Mmi>mi>πmi>290mi>MeV>; this enables us to control the extrapolation to the physical light-quark masses and continuum. For the mi>b> quarks we use the anisotropic clover action with the relativistic heavy-quark interpretation, such that discretization errors from the heavy-quark action are of the same size as from the light-quark sector. We renormalize the

  8. miR-214 promotes the proliferation and invasion of osteosarcoma cells through direct suppression of LZTS1

    SciTech Connect

    Xu, Zhengyu; Wang, Tao

    2014-06-27

    Highlights: • miR-214 is upregulated in human OS tissues and inversely correlated with LZTS1 expression. • miR-214 directly targets LZTS1 by binding to its 3′-UTR. • miR-214 promotes OS cell proliferation, invasion and tumor growth. • Overexpression of LZTS1 reverses miR-214-induced proliferation and invasion of OS cells. - Abstract: Previous studies have shown that miR-214 functions either as an oncogene or a tumor suppressor in various human cancer types. The role of this microRNA in osteosarcoma (OS) is presently unclear. Here, we demonstrated that miR-214 is frequently upregulated in OS specimens, compared with noncancerous bone tissues. Bioinformatics analysis further revealed leucine zipper, putative tumor suppressor 1 (LZTS1) as a potential target of miR-214. Expression patterns of miR-214 were inversely correlated with those of LZTS1 mRNA and protein in OS tissues. Data from reporter assays showed that miR-214 directly binds to the 3′-untranslated region (3′-UTR) of LZTS1 mRNA and suppresses expression at both transcriptional and translational levels. In functional assays, miR-214 promoted OS cell proliferation, invasion and tumor growth in nude mice, which could be reversed by overexpression of LZTS1. Taken together, our data provide compelling evidence that miR-214 functions as an onco-miRNA in OS, and its oncogenic effects are mediated chiefly through downregulation of LZTS1.

  9. MiR-132 prohibits proliferation, invasion, migration, and metastasis in breast cancer by targeting HN1

    SciTech Connect

    Zhang, Zhan-Guo Chen, Wei-Xun Wu, Yan-Hui Liang, Hui-Fang Zhang, Bi-Xiang

    2014-11-07

    Highlights: • MiR-132 is down-regulated in breast cancer tissues and cell lines. • MiR-132 directly regulates HN1 by binding its 3′ UTR. • MiR-132 shows regulatory role in proliferation, invasion, migration and metastasis. • HN1 is involved in miR-132-mediated cell behavior. • Aberrant HN1 is associated with worse overall survival of breast cancer patients. - Abstract: Accumulating evidence indicates that miRNAs play critical roles in tumorigenesis and cancer progression. This study aims to investigate the role and the underlying mechanism of miR-132 in breast cancer. Here, we report that miR-132 is significantly down-regulated in breast cancer tissues and cancer cell lines. Additional study identifies HN1 as a novel direct target of miR-132. MiR-132 down-regulates HN1 expression by binding to the 3′ UTR of HN1 transcript, thereby, suppressing multiple oncogenic traits such as cancer cell proliferation, invasion, migration and metastasis in vivo and in vitro. Overexpression of HN1 restores miR-132-suppressed malignancy. Importantly, higher HN1 expression is significantly associated with worse overall survival of breast cancer patients. Taken together, our data demonstrate a critical role of miR-132 in prohibiting cell proliferation, invasion, migration and metastasis in breast cancer through direct suppression of HN1, supporting the potential utility of miR-132 as a novel therapeutic strategy against breast cancer.

  10. An update of a national database of low-level radioactive waste in Canada

    SciTech Connect

    De, P.L.; Barker, R.C.

    1993-03-01

    This paper gives an overview and update of a national database of low-level radioactive waste in Canada. To provide a relevant perspective, Canadian data are compared with US data on annual waste arisings and with disposal initiatives of the US compacts and states. Presented also is an assessment of the data and its implications for disposal solutions in Canada.

  11. miR-421 induces cell proliferation and apoptosis resistance in human nasopharyngeal carcinoma via downregulation of FOXO4

    SciTech Connect

    Chen, Liang; Department of Otolaryngology, Guangzhou General Hospital of PLA Guangzhou Command, Guangzhou 510010 ; Tang, Yanping; Wang, Jian; Yan, Zhongjie; Xu, Ruxiang

    2013-06-14

    Highlights: •miR-421 is upregulated in nasopharyngeal carcinoma. •miR-421 induces cell proliferation and apoptosis resistance. •FOXO4 is a direct and functional target of miR-421. -- Abstract: microRNAs have been demonstrated to play important roles in cancer development and progression. Hence, identifying functional microRNAs and better understanding of the underlying molecular mechanisms would provide new clues for the development of targeted cancer therapies. Herein, we reported that a microRNA, miR-421 played an oncogenic role in nasopharyngeal carcinoma. Upregulation of miR-421 induced, whereas inhibition of miR-421 repressed cell proliferation and apoptosis resistance. Furthermore, we found that upregulation of miR-421 inhibited forkhead box protein O4 (FOXO4) signaling pathway following downregulation of p21, p27, Bim and FASL expression by directly targeting FOXO4 3′UTR. Additionally, we demonstrated that FOXO4 expression is critical for miR-421-induced cell growth and apoptosis resistance. Taken together, our findings not only suggest that miR-421 promotes nasopharyngeal carcinoma cell proliferation and anti-apoptosis, but also uncover a novel regulatory mechanism for inactivation of FOXO4 in nasopharyngeal carcinoma.

  12. FIRST REPORT TO THE PRESIDENT OF THE UNITED STATES OF AMERICA AND THE PRIME MINISTER OF CANADA

    Energy.gov [DOE]

    The first report to the President of th United States of America and the Prime Minister of Canada on U.S.-Canada Clean Energy Initiative, September 16, 2009. 

  13. Roles of miRNAs in microcystin-LR-induced Sertoli cell toxicity

    SciTech Connect

    Zhou, Yuan; Wang, Hui; Wang, Cong; Qiu, Xuefeng; Benson, Mikael; Yin, Xiaoqin; Xiang, Zou; Li, Dongmei; and others

    2015-08-15

    Microcystin (MC)-LR, a cyclic heptapeptide, is a potent reproductive system toxin. To understand the molecular mechanisms of MC-induced reproductive system cytotoxicity, we evaluated global changes of miRNA and mRNA expression in mouse Sertoli cells following MC-LR treatment. Our results revealed that the exposure to MC-LR resulted in an altered miRNA expression profile that might be responsible for the modulation of mRNA expression. Bio-functional analysis indicated that the altered genes were involved in specific cellular processes, including cell death and proliferation. Target gene analysis suggested that junction injury in Sertoli cells exposed to MC-LR might be mediated by miRNAs through the regulation of the Sertoli cell-Sertoli cell pathway. Collectively, these findings may enhance our understanding on the modes of action of MC-LR on mouse Sertoli cells as well as the molecular mechanisms underlying the toxicity of MC-LR on the male reproductive system. - Highlights: • miRNAs were altered in Sertoli cells exposed to MC-LR. • Alerted genes were involved in different cell functions including the cell morphology. • MC-LR adversely affected Sertoli cell junction formation through the regulating miRNAs.

  14. U.S., Canada pipeline work shows gain in 1994

    SciTech Connect

    Watts, J.

    1994-01-01

    Pipeline construction activity in the US and Canada is expected to be down slightly during 1994 from 1993 mileage, even though natural gas pipeline work remains steady on both sides of the border. Pipeline and Gas Journal and Pipeline and Utilities Construction estimate that a total of 3.638 miles of new gas, crude oil and refined products pipeline will be installed during 1994 in the US, down from a total of 4.278 miles built in 1993. Canadian 1994 work remains essentially unchanged in 1994, with 1,094 new miles compared to 1,091 miles in 1993. This paper reviews the proposed construction by region and company. It includes information on mileage, type pipeline, and estimated completion date.

  15. Atomic Energy of Canada Limited LIQUID DYNAMICS FROM NEUTRON SPECTROMETRY

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Atomic Energy of Canada Limited LIQUID DYNAMICS FROM NEUTRON SPECTROMETRY CRNP-1121 by B.N. BRO CKHOUSE, J. BERGSMA, B.A. D A S A N N A C H A R Y A a n d N.K. POPE C h a l k River, O n t a r i o O c t o b e r , 1962 AECL-1576 DISCLAIMER Portions of this document may be illegible in electronic image products. Images are produced from the best available original document. L E G A L N O T I C E T h i s r e p o r t h a s b e e n r e l e a s e d t o t h e U n i t e d S t a t e s A t o m i c E n e r g

  16. The action is in the US and Canada

    SciTech Connect

    Not Available

    1987-08-01

    This article is a summary article of petroleum activity in North America. It is pointed out that there is significant increase in activity in the U.S. and Canada and in general a drop of activity in Mexico. It is projected that U.S. drilling is anticipated to be up 31% over the same period of 1986. In addition, major operators and independents appear to be planning to increase by more than 100% the amount of Wildcat and Off Shore Holes. This significant increase is planned for the Gulf of Mexico area with a record of 625 wells being planned for the second half of 1987. An increase is also shown for Canadian operators but problems are pointed out with regard to natural gas. The article is accompanied by charts showing activity on a state-by-state basis.

  17. New noncatalytic heavy-oil process developed in Canada

    SciTech Connect

    Fisher, I.P.; Souhrada, F.; Woods, H.J.

    1982-11-22

    Describes Gulf Canada's hydrogen addition upgrading process, named Donor Refined Bitumen (DRB), which involves the pyrolysis of the residuum portion of the bitumen or heavy oil in the presence of an efficient hydrogen donor that stabilizes the intermediates from the pyrolyzing bitumen. Advantages are high operability and reliability, low capital and operating costs, high yields and good product quality, feedstock and independence, the use of conventional refinery equipment, and ready availability of high quality donor. Presents a schematic flow sheet of the DRB process showing how bitumen is upgraded sufficiently to allow easy pipelining to a central major upgrading plant. Tables give comparative compositional data on middle distillates; naptha compositions and qualities; and operating costs.

  18. Ionizing Radiation–Inducible miR-27b Suppresses Leukemia Proliferation via Targeting Cyclin A2

    SciTech Connect

    Wang, Bo; Li, Dongping; Kovalchuk, Anna; Litvinov, Dmitry; Kovalchuk, Olga

    2014-09-01

    Purpose: Ionizing radiation is a common carcinogen that is important for the development of leukemia. However, the underlying epigenetic mechanisms remain largely unknown. The goal of the study was to explore microRNAome alterations induced by ionizing radiation (IR) in murine thymus, and to determine the role of IR-inducible microRNA (miRNA/miR) in the development of leukemia. Methods and Materials: We used the well-established C57BL/6 mouse model and miRNA microarray profiling to identify miRNAs that are differentially expressed in murine thymus in response to irradiation. TIB152 human leukemia cell line was used to determine the role of estrogen receptor–α (ERα) in miR-27b transcription. The biological effects of ectopic miR-27b on leukemogenesis were measured by western immunoblotting, cell viability, apoptosis, and cell cycle analyses. Results: Here, we have shown that IR triggers the differential expression of miR-27b in murine thymus tissue in a dose-, time- and sex-dependent manner. miR-27b was significantly down-regulated in leukemia cell lines CCL119 and TIB152. Interestingly, ERα was overexpressed in those 2 cell lines, and it was inversely correlated with miR-27b expression. Therefore, we used TIB152 as a model system to determine the role of ERα in miR-27b expression and the contribution of miR-27b to leukemogenesis. β-Estradiol caused a rapid and transient reduction in miR-27b expression reversed by either ERα-neutralizing antibody or ERK1/2 inhibitor. Ectopic expression of miR-27b remarkably suppressed TIB152 cell proliferation, at least in part, by inducing S-phase arrest. In addition, it attenuated the expression of cyclin A2, although it had no effect on the levels of PCNA, PPARγ, CDK2, p21, p27, p-p53, and cleaved caspase-3. Conclusion: Our data reveal that β-estradiol/ERα signaling may contribute to the down-regulation of miR-27b in acute leukemia cell lines through the ERK1/2 pathway, and that miR-27b may function as a tumor

  19. Curcumin inhibits oral squamous cell carcinoma SCC-9 cells proliferation by regulating miR-9 expression

    SciTech Connect

    Xiao, Can; Wang, Lili; Zhu, Lifang; Zhang, Chenping; Zhou, Jianhua

    2014-11-28

    Highlights: • miR-9 expression level was significantly decreased in OSCC tissues. • Curcumin significantly inhibited SCC-9 cells proliferation. • miR-9 mediates the inhibition of SCC-9 proliferation by curcumin. • Curcumin suppresses Wnt/β-catenin signaling in SCC-9 cells. • miR-9 mediates the suppression of Wnt/β-catenin signaling by curcumin. - Abstract: Curcumin, a phytochemical derived from the rhizome of Curcuma longa, has shown anticancer effects against a variety of tumors. In the present study, we investigated the effects of curcumin on the miR-9 expression in oral squamous cell carcinoma (OSCC) and explored the potential relationships between miR-9 and Wnt/β-catenin pathway in curcumin-mediated OSCC inhibition in vitro. As the results shown, the expression levels of miR-9 were significantly lower in clinical OSCC specimens than those in the adjacent non-tumor tissues. Furthermore, our results indicated that curcumin inhibited OSCC cells (SCC-9 cells) proliferation through up-regulating miR-9 expression, and suppressing Wnt/β-catenin signaling by increasing the expression levels of the GSK-3β, phosphorylated GSK-3β and β-catenin, and decreasing the cyclin D1 level. Additionally, the up-regulation of miR-9 by curcumin in SCC-9 cells was significantly inhibited by delivering anti-miR-9 but not control oligonucleotides. Downregulation of miR-9 by anti-miR-9 not only attenuated the growth-suppressive effects of curcumin on SCC-9 cells, but also re-activated Wnt/β-catenin signaling that was inhibited by curcumin. Therefore, our findings would provide a new insight into the use of curcumin against OSCC in future.

  20. miR-339-5p inhibits alcohol-induced brain inflammation through regulating NF-κB pathway

    SciTech Connect

    Zhang, Yu; Wei, Guangkuan; Di, Zhiyong; Zhao, Qingjie

    2014-09-26

    Graphical abstract: - Highlights: • Alcohol upregulates miR-339-5p expression. • miR-339-5p inhibits the NF-kB pathway. • miR-339-5p interacts with and blocks activity of IKK-beat and IKK-epsilon. • miR-339-5p modulates IL-1β, IL-6 and TNF-α. - Abstract: Alcohol-induced neuroinflammation is mediated by the innate immunesystem. Pro-inflammatory responses to alcohol are modulated by miRNAs. The miRNA miR-339-5p has previously been found to be upregulated in alcohol-induced neuroinflammation. However, little has been elucidated on the regulatory functions of this miRNA in alcohol-induced neuroinflammation. We investigated the function of miR-339-5p in alcohol exposed brain tissue and isolated microglial cells using ex vivo and in vitro techniques. Our results show that alcohol induces transcription of miR 339-5p, IL-6, IL-1β and TNF-α in mouse brain tissue and isolated microglial cells by activating NF-κB. Alcohol activation of NF-κB allows for nuclear translocation of the NF-κB subunit p65 and expression of pro-inflammatory mediators. miR-339-5p inhibited expression of these pro-inflammatory factors through the NF-κB pathway by abolishing IKK-β and IKK-ε activity.

  1. miR-208-3p promotes hepatocellular carcinoma cell proliferation and invasion through regulating ARID2 expression

    SciTech Connect

    Yu, Peng; Wu, Dingguo; You, Yu; Sun, Jing; Lu, Lele; Tan, Jiaxing; Bie, Ping

    2015-08-15

    MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at post-transcriptional level. miRNA dysregulation plays a causal role in cancer progression. In this study, miR-208-3p was highly expressed and directly repressed ARID2 expression. As a result, ARID2 expression in hepatocellular carcinoma (HCC) was decreased. In vitro, miR-208-3p down-regulation and ARID2 over-expression elicited similar inhibitory effects on HCC cell proliferation and invasion. In vivo test results revealed that miR-208-3p down-regulation inhibited HCC tumorigenesis in Hep3B cells. Moreover, ARID2 was possibly a downstream element of transforming growth factor beta1 (TGFβ1)/miR-208-3p/ARID2 regulatory pathway. These findings suggested that miR-208-3p up-regulation is associated with HCC cell progression and may provide a new target for liver cancer treatment. - Highlights: • miR-208-3p was highly expressed and directly repressed the expression of ARID2 in HCC. • miR-208-3p contributed to HCC cell progression both in vitro and in vivo. • Over-expression of ARID2 inhibited the HCC cell proliferation and invasion. • Restoration of ARID2 partly reversed the the effect of miR-208-3p down-regulation on HCC cells. • Newly regulatory pathway: miR-208-3p mediated the repression of ARID2 by TGFβ1 in HCC cells.

  2. This Week In Petroleum Summary Printer-Friendly Version

    Annual Energy Outlook

    The Midwest and Rocky Mountains (PADDs 2 and 4, respectively), despite sharing a border with Canada, conduct minimal global trade in gasoline and distillate (Figure 3)....

  3. MicroRNAs expression in ox-LDL treated HUVECs: MiR-365 modulates apoptosis and Bcl-2 expression

    SciTech Connect

    Qin, Bing; Xiao, Bo; Liang, Desheng; Xia, Jian; Li, Ye; Yang, Huan

    2011-06-24

    Highlights: {yields} We evaluated the role of miRNAs in ox-LDL induced apoptosis in ECs. {yields} We found 4 up-regulated and 11 down-regulated miRNAs in apoptotic ECs. {yields} Target genes of the dysregulated miRNAs regulate ECs apoptosis and atherosclerosis. {yields} MiR-365 promotes ECs apoptosis via suppressing Bcl-2 expression. {yields} MiR-365 inhibitor alleviates ECs apoptosis induced by ox-LDL. -- Abstract: Endothelial cells (ECs) apoptosis induced by oxidized low-density lipoprotein (ox-LDL) is thought to play a critical role in atherosclerosis. MicroRNAs (miRNAs) are a class of noncoding RNAs that posttranscriptionally regulate the expression of genes involved in diverse cell functions, including differentiation, growth, proliferation, and apoptosis. However, whether miRNAs are associated with ox-LDL induced apoptosis and their effect on ECs is still unknown. Therefore, this study evaluated potential miRNAs and their involvement in ECs apoptosis in response to ox-LDL stimulation. Microarray and qRT-PCR analysis performed on human umbilical vein endothelial cells (HUVECs) exposed to ox-LDL identified 15 differentially expressed (4 up- and 11 down-regulated) miRNAs. Web-based query tools were utilized to predict the target genes of the differentially expressed miRNAs, and the potential target genes were classified into different function categories with the gene ontology (GO) term and KEGG pathway annotation. In particular, bioinformatics analysis suggested that anti-apoptotic protein B-cell CLL/lymphoma 2 (Bcl-2) is a target gene of miR-365, an apoptomir up-regulated by ox-LDL stimulation in HUVECs. We further showed that transfection of miR-365 inhibitor partly restored Bcl-2 expression at both mRNA and protein levels, leading to a reduction of ox-LDL-mediated apoptosis in HUVECs. Taken together, our findings indicate that miRNAs participate in ox-LDL-mediated apoptosis in HUVECs. MiR-365 potentiates ox-LDL-induced ECs apoptosis by regulating the

  4. Canada Geese at the Hanford Site Trends in Reproductive Success, Migration Patterns, and Contaminant Concentrations

    SciTech Connect

    Simmons, Mary Ann; Poston, Ted M.; Tiller, Brett L.; Stegen, Amanda; Hand, Kristine D.; Brandenberger, Jill M.

    2010-05-25

    Pacific Northwest National Laboratory (PNNL) has conducted several studies for the U.S. Department of Energy (DOE) to evaluate the status and condition of Canada geese on the Hanford Reach of the Columbia River. This report summarizes results of studies of Canada geese (Branta canadensis moffitti) at the Hanford Site dating back to the 1950s. Results include information on the nesting (reproductive) success of Canada geese using the Hanford Reach, review of the local and regional migration of this species using data from bird banding studies, and summary data describing monitoring and investigations of the accumulation of Hanford-derived and environmental contaminants by resident goose populations.

  5. Secretary Chu Opens U.S.-Canada Clean Energy Dialogue | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energy Opens U.S.-Canada Clean Energy Dialogue Secretary Chu Opens U.S.-Canada Clean Energy Dialogue June 29, 2009 - 12:00am Addthis Washington, DC - U.S. Energy Secretary Steven Chu today made opening remarks at the first U.S.-Canada Clean Energy Dialogue Roundtable at the Department of Energy Headquarters in Washington, DC. The public-private meeting, which will be held June 29-30, is bringing together leaders from private industry to meet with U.S. and Canadian energy leaders to solicit

  6. Canada is putting teeth into its price fixing and rigging laws

    SciTech Connect

    McWilliams, H.

    1991-12-01

    This paper reports that attendees at the 24th annual Transportation Symposium sponsored by the Propane Gas Association of Canada (PGAC) and held in Calgary, Alberta Oct. 23-24 heard some straight talk about renewed interest in enforcing Canada's Competition Act. Three years ago, a senior official of the Bureau of Competition Policy called certain price-related offenses under the Competition Act the most serious of economic crimes and declared that their enforcement is the cornerstone of Canada's competition laws. With this in mind, the Bureau intends to deal firmly with both business and individuals who engage in such practices.

  7. MiRNA-125a-5p inhibits glioblastoma cell proliferation and promotes cell differentiation by targeting TAZ

    SciTech Connect

    Yuan, Jian; Xiao, Gelei; Peng, Gang; Liu, Dingyang; Wang, Zeyou; Liao, Yiwei; Liu, Qing; Wu, Minghua; Yuan, Xianrui

    2015-02-06

    Highlights: • Expression of miR-125a-5p is inversely correlated with that of TAZ in glioma cells. • MiR-125a-5p represses TAZ expression in glioma cells. • MiR-125a-5p directly targets the 3′ UTR of TAZ mRNA and promotes its degradation. • MiR-125a-5p represses CTGF and survivin via TAZ, and inhibits glioma cell growth. • MiR-125a-5p inhibits the stem cell features of HFU-251 MG cells. - Abstract: Glioblastoma (GBM) is the most lethal brain tumor due to the resistance to conventional therapies, such as radiotherapy and chemotherapy. TAZ, an important mediator of the Hippo pathway, was found to be up-regulated in diverse cancers, including in GBM, and plays important roles in tumor initiation and progression. However, little is known about the regulation of TAZ expression in tumors. In this study, we found that miR-125a-5p is an important regulator of TAZ in glioma cells by directly targeting the TAZ 3′ UTR. MiR-125a-5p levels are inversely correlated with that of TAZ in normal astrocytes and a panel of glioma cell lines. MiR-125a-5p represses the expression of TAZ target genes, including CTGF and survivin, and inhibits cell proliferation and induces the differentiation of GBM cells; whereas over-expression of TAZ rescues the effects of miR-125a-5p. This study revealed a mechanism for TAZ deregulation in glioma cells, and also demonstrated a tumor suppressor role of miR-125a-5p in glioblastoma cells.

  8. The NuMI proton beam at Fermilab successes and challenges

    SciTech Connect

    Childress, S.; /Fermilab

    2008-11-01

    The NuMI beam at Fermilab has delivered over 5 x 10{sup 20} 120 GeV protons to the neutrino production target since the start for MINOS [1] neutrino oscillation experiment operation in 2005. We report on proton beam commissioning and operation status, including successes and challenges with this beam.

  9. DOE Zero Energy Ready Home Case Study: Cobblestone Homes, Midland, MI

    Office of Energy Efficiency and Renewable Energy (EERE)

    Case study of a DOE Zero Energy Ready home in Midland, MI, that scored HERS 49 without PV or HERS 44 with 1.4 kW of PV. The custom home served as a prototype and energy efficiency demonstration...

  10. U.S.-Canada Clean Energy Dialogue Second Report to Leaders

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    President Obama and Prime Minister Harper: As the delegated co-leads for the U.S.-Canada Clean Energy Dialogue, we are pleased to take this opportunity to update you on the ...

  11. TransCanada Power Mktg Ltd (New Hampshire) | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Place: New Hampshire Phone Number: 1.800.661.3805 Website: www.transcanada.comindex.html Twitter: @TransCanada Outage Hotline: 1-800-447-8066 References: EIA Form EIA-861 Final...

  12. EXC-13-0004- In the Matter of Liebherr Canada Ltd.

    Energy.gov [DOE]

    On November 6, 2013, OHA issued a decision granting an Application for Exception filed by Liebherr Canada Ltd. (Liebherr).  In its Application, Liebherr sought relief from the provisions of 10 C.F...

  13. U.S.-Canada Clean Energy Dialogue (CED) Action Plan II

    Energy.gov [DOE]

    Action Plan II describes initiatives that the U.S.-Canada Clean Energy Dialogue Working Groups plan to implement under Phase II of the CED to further progress toward a low-carbon economy that...

  14. MiR-18a regulates the proliferation, migration and invasion of human glioblastoma cell by targeting neogenin

    SciTech Connect

    Song, Yichen; Wang, Ping; Zhao, Wei; Yao, Yilong; Liu, Xiaobai; Ma, Jun; Xue, Yixue; Liu, Yunhui

    2014-05-15

    MiR-17-92 cluster has recently been reported as an oncogene in some tumors. However, the association of miR-18a, an important member of this cluster, with glioblastoma remains unknown. Therefore, this study aims to investigate the expression of miR-18a in glioblastoma and its role in biological behavior of U87 and U251 human glioblastoma cell lines. Quantitative RT-PCR results showed that miR-18a was highly expressed in glioblastoma tissues and U87 and U251 cell lines compared with that in human brain tissues and primary normal human astrocytes, and the expression levels were increased along with the rising pathological grades of glioblastoma. Neogenin was identified as the target gene of miR-18a by dual-luciferase reporter assays. RT-PCR and western blot results showed that its expression levels were decreased along with the rising pathological grades of glioblastoma. Inhibition of miR-18a expression was established by transfecting exogenous miR-18a inhibitor into U87 and U251 cells, and its effects on the biological behavior of glioblastoma cells were studied using CCK-8 assay, transwell assay and flow cytometry. Inhibition of miR-18a expression in U87 and U251 cells significantly up-regulated neogenin, and dramatically suppressed the abilities of cell proliferation, migration and invasion, induced cell cycle arrest and promoted cellular apoptosis. Collectively, these results suggest that miR-18a may regulate biological behavior of human glioblastoma cells by targeting neogenin, and miR-18a can serve as a potential target in the treatment of glioblastoma. - Highlights: • MiR-18a was highly expressed in glioblastoma tissues and U87 and U251 cell lines. • Neogenin was identified as the target gene of miR-18a. • Neogenin expressions were decreased along with the rising pathological grades of glioblastoma. • Inhibition of miR-18a suppressed biological behavior of glioma cells by up-regulating neogenin.

  15. U.S. - Canada Power System Outage Task Force: Final Report on the

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Implementation of Task Force Recommendations | Department of Energy - Canada Power System Outage Task Force: Final Report on the Implementation of Task Force Recommendations U.S. - Canada Power System Outage Task Force: Final Report on the Implementation of Task Force Recommendations On August 14, 2003, the largest power blackout in North American history affected an area with an estimated 50 million people and 61,800 megawatts (MW) of electric load in the states of Ohio, Michigan,

  16. Guidance on Implementing the Agreement Between Canada and the United States of America on Government Procurement

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    RECOVERY ACT BUY AMERICAN GUIDANCE ON IMPLEMENTING THE AGREEMENT BETWEEN CANADA AND THE UNITED STATES OF AMERICA ON GOVERNMENT PROCUREMENT EFFECTIVE DATE: May 24, 2010 SUBJECT: IMPLICATIONS OF THE AGREEMENT BETWEEN CANADA AND THE UNITED STATES OF AMERICA ON GOVERNMENT PROCUREMENT FOR EERE RECOVERY ACT FINANCIAL ASSISTANCE RECIPIENTS IMPLEMENTING THE BUY AMERICAN PROVISION PURPOSE: Section 1605 (the Buy American provision) of the American Reinvestment and Recovery Act of 2009 (Recovery Act) will

  17. miR-7 and miR-218 epigenetically control tumor suppressor genes RASSF1A and Claudin-6 by targeting HoxB3 in breast cancer

    SciTech Connect

    Li, Qiaoyan; Zhu, Fufan; Chen, Puxiang

    2012-07-20

    Highlights: Black-Right-Pointing-Pointer Both miR-7 and miR-218 down-regulates HoxB3 expression by targeting the 3 Prime -UTR of HoxB3 mRNA. Black-Right-Pointing-Pointer A reverse correlation between the levels of endogenous miR-7, miR218 and HoxB3 expression. Black-Right-Pointing-Pointer Epigenetic changes involve in the reactivation of HoxB3. Black-Right-Pointing-Pointer Both miRNAs inhibits the cell cycle and clone formation of breast cancer cells. -- Abstract: Many microRNAs have been implicated as key regulators of cellular growth and differentiation and have been found to dysregulate proliferation in human tumors, including breast cancer. Cancer-linked microRNAs also alter the epigenetic landscape by way of DNA methylation and post-translational modifications of histones. Aberrations in Hox gene expression are important for oncogene or tumor suppressor during abnormal development and malignancy. Although recent studies suggest that HoxB3 is critical in breast cancer, the putative role(s) of microRNAs impinging on HoxB3 is not yet fully understood. In this study, we found that the expression levels of miR-7 and miR-218 were strongly and reversely associated with HoxB3 expression. Stable overexpression of miR-7 and miR-218 was accompanied by reactivation of tumor suppressor genes including RASSF1A and Claudin-6 by means of epigenetic switches in DNA methylation and histone modification, giving rise to inhibition of the cell cycle and clone formation of breast cancer cells. The current study provides a novel link between overexpression of collinear Hox genes and multiple microRNAs in human breast malignancy.

  18. The Low-Level Radioactive Waste Management Office: Thirty Years of Experience in Canada - 13308

    SciTech Connect

    Benitez, Liliana; Gardiner, Mark J.; Zelmer, Robert L.; Gardiner, Mark J.; Zelmer, Robert L.

    2013-07-01

    This paper reviews thirty years of progress by the Low-Level Radioactive Waste Management Office (LLRWMO) in developing and implementing low-level radioactive waste (LLRW) remediation projects and environmentally safe co-existence strategies. It reports on the present status and the future of the national historic waste program in Canada. There are over two million cubic metres of historic LLRW in Canada. Historic LLRW is broadly defined as LLRW that was managed in the past in a manner that is no longer considered acceptable and for which the original owner cannot reasonably be held accountable. In many cases, the original owner can not be identified or no longer exists. The LLRWMO was established in 1982 as Canada's agent to carry out the responsibilities of the federal government for the management of historic LLRW. The LLRWMO is operated by Atomic Energy of Canada Limited (AECL) through a cost-recovery agreement with Natural Resources Canada (NRCan), the federal department that provides the funding and establishes national policy for radioactive waste management in Canada. The LLRWMO expertise includes project managers, environmental remediation specialists, radiation surveyors, communications staff and administrative support staff. The LLRWMO in providing all aspects of project oversight and implementation contracts additional resources supplementing core staff capacity as project/program demands require. (authors)

  19. Loss of expression of miR-335 is implicated in hepatic stellate cell migration and activation

    SciTech Connect

    Chen, Chao; Wu, Chao-Qun; Zhang, Zong-Qi; Yao, Ding-Kang; Zhu, Liang

    2011-07-15

    Activation and migration of resident stellate cells (HSCs) within the hepatic space of Disse play an important role in hepatic fibrosis, which accounts for the increased numbers of activated HSCs in areas of inflammation during hepatic fibrosis. Currently, microRNAs have been found to play essential roles in HSC differentiation, proliferation, apoptosis, fat accumulation and collagen production. However, little is known about microRNA mediated HSC activation and migration. In this study, the miRNA expression profiles of quiescent HSCs, partially activated HSCs and fully activated HSCs were compared in pairs. Gene ontology (GO) and GO-Map network analysis indicated that the activation of HSCs was regulated by microRNAs. Among them miR-335 was confirmed to be significantly reduced during HSC activation by qRT-PCR, and restoring expression of miR-335 inhibited HSC migration and reduced {alpha}-SMA and collagen type I. Previous study revealed that tenascin-C (TNC), an extracellular matrix glycoprotein involved in cell migration, might be a target of miR-335. Therefore, we further studied the TNC expression in miR-335 over-expressed HSCs. Our data showed that exogenous TNC could enhance HSC migration in vitro and miR-335 restoration resulted in a significant inhibition of TNC expression. These results demonstrated that miR-335 restoration inhibited HSC migration, at least in part, via downregulating the TNC expression.

  20. PSMB4 promotes multiple myeloma cell growth by activating NF-κB-miR-21 signaling

    SciTech Connect

    Zheng, Peihao; Guo, Honggang; Li, Guangchao; Han, Siqi; Luo, Fei; Liu, Yi

    2015-03-06

    Proteasomal subunit PSMB4, was recently identified as potential cancer driver genes in several tumors. However, the regulatory mechanism of PSMB4 on carcinogenesis process remains unclear. In this study, we investigated the expression and roles of PSMB4 in multiple myeloma (MM). We found a significant up-regulation of PSMB4 in MM plasma and cell lines. Ectopic overexpression of PSMB4 promoted cell growth and colony forming ability of MM cells, whereas inhibition of PSMB4 led to a decrease of such events. Furthermore, our results demonstrated the up-regulation of miR-21 and a positive correlation between the levels of miR-21 and PSMB4 in MM. Re-expression of miR-21 markedly rescued PSMB4 knockdown-mediated suppression of cell proliferation and clone-formation. Additionally, while enforced expression of PSMB4 profoundly increased NF-κB activity and the level of miR-21, PSMB4 knockdown or NF-κB inhibition suppressed miR-21 expression in MM cells. Taken together, our results demonstrated that PSMB4 regulated MM cell growth in part by activating NF-κB-miR-21 signaling, which may represent promising targets for novel specific therapies. - Highlights: • First reported upregulation of PSMB4 in MM plasma and cell lines. • PSMB4 promoted MM cell growth and colony forming ability. • Further found miR-21 was up-regulated by PSMB4 in MM plasma and cell lines. • PSMB4-induced miR-21 expression was modulated by NF-κB. • PSMB4-NF-κB-miR-21 axis may be potential therapeutic targets of MM.

  1. RLIP76-dependent suppression of PI3K/AKT/Bcl-2 pathway by miR...

    Office of Scientific and Technical Information (OSTI)

    in prostate cancer Citation Details In-Document Search Title: RLIP76-dependent suppression of PI3KAKTBcl-2 pathway by miR-101 induces apoptosis in prostate cancer MicroRNA-101 ...

  2. Aryl hydrocarbon receptor-dependent regulation of miR-196a expression controls lung fibroblast apoptosis but not proliferation

    SciTech Connect

    Hecht, Emelia; Zago, Michela; Sarill, Miles; Rico de Souza, Angela; Gomez, Alvin; Matthews, Jason; Hamid, Qutayba; Eidelman, David H.; Baglole, Carolyn J.

    2014-11-01

    The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor implicated in the regulation of apoptosis and proliferation. Although activation of the AhR by xenobiotics such as dioxin inhibits the cell cycle and control apoptosis, paradoxically, AhR expression also promotes cell proliferation and survival independent of exogenous ligands. The microRNA (miRNA) miR-196a has also emerged as a regulator of proliferation and apoptosis but a relationship between the AhR and miR-196a is not known. Therefore, we hypothesized that AhR-dependent regulation of endogenous miR-196a expression would promote cell survival and proliferation. Utilizing lung fibroblasts from AhR deficient (AhR{sup −/−}) and wild-type (AhR{sup +/+}) mice, we show that there is ligand-independent regulation of miRNA, including low miR-196a in AhR{sup −/−} cells. Validation by qRT-PCR revealed a significant decrease in basal expression of miR-196a in AhR{sup −/−} compared to AhR{sup +/+} cells. Exposure to AhR agonists benzo[a]pyrene (B[a]P) and FICZ as well as AhR antagonist CH-223191 decreased miR-196a expression in AhR{sup +/+} fibroblasts concomitant with decreased AhR protein levels. There was increased proliferation only in AhR{sup +/+} lung fibroblasts in response to serum, corresponding to a decrease in p27{sup KIP1} protein, a cyclin-dependent kinase inhibitor. Increasing the cellular levels of miR-196a had no effect on proliferation or expression of p27{sup KIP1} in AhR{sup −/−} fibroblasts but attenuated cigarette smoke-induced apoptosis. This study provides the first evidence that AhR expression is essential for the physiological regulation of cellular miRNA levels- including miR-196a. Future experiments designed to elucidate the functional relationship between the AhR and miR-196a may delineate additional novel ligand-independent roles for the AhR. - Highlights: • The AhR controls proliferation and apoptosis in lung cells. • The AhR regulates the

  3. Material Activation Benchmark Experiments at the NuMI Hadron Absorber Hall in Fermilab

    SciTech Connect

    Matsumura, H.; Matsuda, N.; Kasugai, Y.; Toyoda, A.; Yashima, H.; Sekimoto, S.; Iwase, H.; Oishi, K.; Sakamoto, Y.; Nakashima, H.; Leveling, A.; Boehnlein, D.; Lauten, G.; Mokhov, N.; Vaziri, K.

    2014-06-15

    In our previous study, double and mirror symmetric activation peaks found for Al and Au arranged spatially on the back of the Hadron absorber of the NuMI beamline in Fermilab were considerably higher than those expected purely from muon-induced reactions. From material activation bench-mark experiments, we conclude that this activation is due to hadrons with energy greater than 3 GeV that had passed downstream through small gaps in the hadron absorber.

  4. Measurement of Pi-K Ratios from the NuMI Target

    SciTech Connect

    Seun, Sin Man

    2007-07-01

    Interactions of protons (p) with the NuMI (Neutrinos at the Main Injector) target are used to create the neutrino beam for the MINOS (Main Injector Neutrino Oscillation Search) Experiment. Using the MIPP (Main Injector Particle Production) experimental apparatus, the production of charged pions and kaons in p+NuMI interactions is studied. The data come from a sample of 2 x 106 events obtained by MIPP using the 120 GeV/c proton beam from the Main Injector at Fermi National Accelerator Laboratory in Illinois, USA. Pions and kaons are identified by measurement in a Ring Imaging Cherenkov detector. Presented are measurements of π-+, K-/K+, π+/K+ and π-/K- production ratios in the momentum range pT < 2 GeV/c transversely and 20 GeV/c < pz < 90 GeV/c longitudinally. Also provided are detailed comparisons of the MIPP NuMI data with the MIPP Thin Carbon data, the MIPP Monte Carlo simulation and the current MINOS models in the relevant momentum ranges.

  5. miR-21 modulates tumor outgrowth induced by human adipose tissue-derived mesenchymal stem cells in vivo

    SciTech Connect

    Shin, Keun Koo; Lee, Ae Lim; Kim, Jee Young; Medical Research Center for Ischemic Tissue Engineering, Pusan National University, Yangsan, Gyeongnam 626-870; BK21 Medical Science Education Center, School of Medicine, Pusan National University, Yangsan, Gyeongnam 626-870 ; Lee, Sun Young; Medical Research Center for Ischemic Tissue Engineering, Pusan National University, Yangsan, Gyeongnam 626-870 ; Bae, Yong Chan; Jung, Jin Sup

    2012-06-15

    Highlights: Black-Right-Pointing-Pointer miR-21 modulates hADSC-induced increase of tumor growth. Black-Right-Pointing-Pointer The action is mostly mediated by the modulation of TGF-{beta} signaling. Black-Right-Pointing-Pointer Inhibition of miR-21 enhances the blood flow recovery in hindlimb ischemia. -- Abstract: Mesenchymal stem cells (MSCs) have generated a great deal of interest in clinical situations, due principally to their potential use in regenerative medicine and tissue engineering applications. However, the therapeutic application of MSCs remains limited, unless the favorable effects of MSCs on tumor growth in vivo, and the long-term safety of the clinical applications of MSCs, can be more thoroughly understood. In this study, we determined whether microRNAs can modulate MSC-induced tumor outgrowth in BALB/c nude mice. Overexpression of miR-21 in human adipose-derived stem cells (hADSCs) inhibited hADSC-induced tumor growth, and inhibition of miR-21 increased it. Downregulation of transforming growth factor beta receptor II (TGFBR2), but not of signal transducer and activator of transcription 3, in hADSCs showed effects similar to those of miR-21 overexpression. Downregulation of TGFBR2 and overexpression of miR21 decreased tumor vascularity. Inhibition of miR-21 and the addition of TGF-{beta} increased the levels of vascular endothelial growth factor and interleukin-6 in hADSCs. Transplantation of miR-21 inhibitor-transfected hADSCs increased blood flow recovery in a hind limb ischemia model of nude mice, compared with transplantation of control oligo-transfected cells. These findings indicate that MSCs might favor tumor growth in vivo. Thus, it is necessary to study the long-term safety of this technique before MSCs can be used as therapeutic tools in regenerative medicine and tissue engineering.

  6. Targeting miR-21 enhances the sensitivity of human colon cancer HT-29 cells to chemoradiotherapy in vitro

    SciTech Connect

    Deng, Jun; Lei, Wan; Fu, Jian-Chun; Zhang, Ling; Li, Jun-He; Xiong, Jian-Ping

    2014-01-17

    Highlight: MiR-21 plays a significant role in 5-FU resistance. This role might be attributed to targeting of hMSH2 as well as TP and DPD via miR-21 targeted hMSH2. Indirectly targeted TP and DPD to influence 5-FU chemotherapy sensitivity. -- Abstract: 5-Fluorouracil (5-FU) is a classic chemotherapeutic drug that has been widely used for colorectal cancer treatment, but colorectal cancer cells are often resistant to primary or acquired 5-FU therapy. Several studies have shown that miR-21 is significantly elevated in colorectal cancer. This suggests that this miRNA might play a role in this resistance. In this study, we investigated this possibility and the possible mechanism underlying this role. We showed that forced expression of miR-21 significantly inhibited apoptosis, enhanced cell proliferation, invasion, and colony formation ability, promoted G1/S cell cycle transition and increased the resistance of tumor cells to 5-FU and X radiation in HT-29 colon cancer cells. Furthermore, knockdown of miR-21 reversed these effects on HT-29 cells and increased the sensitivity of HT-29/5-FU to 5-FU chemotherapy. Finally, we showed that miR-21 targeted the human mutS homolog2 (hMSH2), and indirectly regulated the expression of thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD). These results demonstrate that miR-21 may play an important role in the 5-FU resistance of colon cancer cells.

  7. Overview of the Government of Canada Nuclear Legacy Liabilities Program - 13551

    SciTech Connect

    Metcalfe, D.; McCauley, D.; Miller, J.; Brooks, S.

    2013-07-01

    Nuclear legacy liabilities have resulted from more than 60 years of nuclear research and development carried out on behalf of Canada. The liabilities are located at Atomic Energy of Canada Limited's (AECL) Chalk River Laboratories in Ontario and Whiteshell Laboratories in Manitoba, as well as three shutdown prototype reactors in Ontario and Quebec that are being maintained in a safe storage state. Estimated at about $7.4 billion (current day dollars), these liabilities consist of disused nuclear facilities and associated infrastructure, a wide variety of buried and stored waste, and contaminated lands. In 2006, the Government of Canada adopted a long-term strategy to deal with the nuclear legacy liabilities and initiated a five-year, $520 million start-up phase, thereby creating the Nuclear Legacy Liabilities Program (NLLP). The Government of Canada renewed the NLLP in 2011 with a $439-million three-year second phase that ends March 31, 2014. The projects and activities carried out under the Program focus on infrastructure decommissioning, environmental restoration, improving the management of legacy radioactive waste, and advancing the long-term strategy. The NLLP is being implemented through a Memorandum of Understanding between Natural Resources Canada (NRCan) and AECL whereby NRCan is responsible for policy direction and oversight, including control of funding, and AECL is responsible for implementing the program of work and holding and administering all licences, facilities and lands. (authors)

  8. miR-502 inhibits cell proliferation and tumor growth in hepatocellular carcinoma through suppressing phosphoinositide 3-kinase catalytic subunit gamma

    SciTech Connect

    Chen, Suling; Li, Fang; Chai, Haiyun; Tao, Xin; Wang, Haili; Ji, Aifang

    2015-08-21

    MicroRNAs (miRNAs) play a key role in carcinogenesis and tumor progression in hepatocellular carcinoma (HCC). In the present study, we demonstrated that miR-502 significantly inhibits HCC cell proliferation in vitro and tumor growth in vivo. G1/S cell cycle arrest and apoptosis of HCC cells were induced by miR-502. Phosphoinositide 3-kinase catalytic subunit gamma (PIK3CG) was identified as a direct downstream target of miR-502 in HCC cells. Notably, overexpression of PIK3CG reversed the inhibitory effects of miR-502 in HCC cells. Our findings suggest that miR-502 functions as a tumor suppressor in HCC via inhibition of PI3KCG, supporting its utility as a promising therapeutic gene target for this tumor type. - Highlights: • miR-502 suppresses HCC cell proliferation in vitro and tumorigenicity in vivo. • miR-502 regulates cell cycle and apoptosis in HCC cells. • PIK3CG is a direct target of miR-502. • miR-502 and PIK3CG expression patterns are inversely correlated in HCC tissues.

  9. RLIP76-dependent suppression of PI3K/AKT/Bcl-2 pathway by miR-101 induces apoptosis in prostate cancer

    SciTech Connect

    Yang, Jing; Song, Qi; Cai, Yi; Wang, Peng; Wang, Min; Zhang, Dong

    2015-08-07

    MicroRNA-101 (miR-101) participates in carcinogenesis and tumor progression in various cancers. However, its biological functions in prostate cancer are still unclear. Here, we demonstrate that miR-101 represents a critical role in regulating cell apoptosis in prostate cancer cells. We first demonstrated that miR-101 treatment promoted apoptosis in DU145 and PC3 cells by using flow cytometric analysis and transmission electron microscopy (TEM). To verify the mechanisms, we identified a novel miR-101 target, Ral binding protein 1 (RLIP76). We found miR-101 transfection significantly suppresses RLIP76 expression, which can transactivate phosphorylation of PI3K-Akt signaling, and resulted in an amplification of Bcl2-induced apoptosis. Furthermore, we demonstrated that RLIP76 overexpression could reverse the anti-tumor effects of miR-101 in DU145 and PC3 cells by using flow cytometry assay and MTT assay. Taken together, our results revealed that the effect of miR-101 on prostate cancer cell apoptosis was due to RLIP76 regulation of the PI3K/Akt/Bcl-2 signaling pathway. - Highlights: • miR-101 inhibited prostate cancer cell proliferation and enhanced apoptosis. • miR-101 directly targeted and regulated RLIP76 expression. • miR-101 suppressed PI3K/Akt/Bcl-2 signaling pathway by targeting RLIP76.

  10. MiR-20a Induces Cell Radioresistance by Activating the PTEN/PI3K/Akt Signaling Pathway in Hepatocellular Carcinoma

    SciTech Connect

    Zhang, Yuqin; Zheng, Lin; Ding, Yi; Li, Qi; Wang, Rong; Liu, Tongxin; Sun, Quanquan; Yang, Hua; Peng, Shunli; Wang, Wei; Chen, Longhua

    2015-08-01

    Purpose: To investigate the role of miR-20a in hepatocellular carcinoma (HCC) cell radioresistance, which may reveal potential strategies to improve treatment. Methods and Materials: The expression of miR-20a and PTEN were detected in HCC cell lines and paired primary tissues by quantitative real-time polymerase chain reaction. Cell radiation combined with colony formation assays was administrated to discover the effect of miR-20a on radiosensitivity. Bioinformatics prediction and luciferase assay were used to identify the target of miR-20a. The phosphatidylinositol 3-kinase inhibitor LY294002 was used to inhibit phosphorylation of Akt, to verify whether miR-20a affects HCC cell radioresistance through activating the PTEN/PI3K/Akt pathway. Results: MiR-20a levels were increased in HCC cell lines and tissues, whereas PTEN was inversely correlated with it. Overexpression of miR-20a in Bel-7402 and SMMC-7721 cells enhances their resistance to the effect of ionizing radiation, and the inhibition of miR-20a in HCCLM3 and QGY-7701 cells sensitizes them to it. PTEN was identified as a direct functional target of miR-20a for the induction of radioresistance. Overexpression of miR-20a activated the PTEN/PI3K/Akt signaling pathway. Additionally, the kinase inhibitor LY294002 could reverse the effect of miR-20a–induced radioresistance. Conclusion: MiR-20a induces HCC cell radioresistance by activating the PTEN/PI3K/Akt pathway, which suggests that miR-20a/PTEN/PI3K/Akt might represent a target of investigation for developing effective therapeutic strategies against HCC.

  11. ,"Babb, MT Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Babb, MT Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  12. ,"Calais, ME Natural Gas Pipeline Exports to Canada (Million Cubic Feet)"

    Energy Information Administration (EIA) (indexed site)

    Exports to Canada (Million Cubic Feet)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Calais, ME Natural Gas Pipeline Exports to Canada (Million Cubic Feet)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  13. ,"Calais, ME Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Calais, ME Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  14. ,"Champlain, NY Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Champlain, NY Natural Gas Pipeline Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Champlain, NY Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  15. ,"Compressed U.S. Natural Gas Exports to Canada (Million Cubic Feet)"

    Energy Information Administration (EIA) (indexed site)

    to Canada (Million Cubic Feet)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Compressed U.S. Natural Gas Exports to Canada (Million Cubic Feet)",1,"Monthly","8/2016" ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  16. ,"Compressed U.S. Natural Gas Imports from Canada (Million Cubic Feet)"

    Energy Information Administration (EIA) (indexed site)

    from Canada (Million Cubic Feet)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Compressed U.S. Natural Gas Imports from Canada (Million Cubic Feet)",1,"Monthly","8/2016" ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  17. ,"Corsby, ND Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Corsby, ND Natural Gas Pipeline Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Corsby, ND Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  18. ,"Eastport, ID Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Eastport, ID Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  19. ,"Grand Island, NY Natural Gas Pipeline Exports to Canada (Million Cubic Feet)"

    Energy Information Administration (EIA) (indexed site)

    Exports to Canada (Million Cubic Feet)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Grand Island, NY Natural Gas Pipeline Exports to Canada (Million Cubic Feet)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  20. ,"Grand Island, NY Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Grand Island, NY Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  1. ,"Havre, MT Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Havre, MT Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2003 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  2. ,"Highgate Springs, VT Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Highgate Springs, VT Natural Gas Pipeline Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Highgate Springs, VT Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016"

  3. ,"International Falls, MN Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    International Falls, MN Natural Gas Pipeline Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","International Falls, MN Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2006 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016"

  4. ,"Massena, NY Natural Gas Pipeline Exports to Canada (Million Cubic Feet)"

    Energy Information Administration (EIA) (indexed site)

    Exports to Canada (Million Cubic Feet)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Massena, NY Natural Gas Pipeline Exports to Canada (Million Cubic Feet)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  5. ,"Massena, NY Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Massena, NY Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  6. ,"Waddington, NY Natural Gas Pipeline Exports to Canada (Million Cubic Feet)"

    Energy Information Administration (EIA) (indexed site)

    Exports to Canada (Million Cubic Feet)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Waddington, NY Natural Gas Pipeline Exports to Canada (Million Cubic Feet)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  7. ,"Waddington, NY Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Waddington, NY Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  8. ,"Warroad, MN Natural Gas Pipeline Exports to Canada (Million Cubic Feet)"

    Energy Information Administration (EIA) (indexed site)

    Exports to Canada (Million Cubic Feet)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Warroad, MN Natural Gas Pipeline Exports to Canada (Million Cubic Feet)",1,"Annual",2003 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  9. ,"Warroad, MN Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Warroad, MN Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  10. ,"Whitlash, MT Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Whitlash, MT Natural Gas Pipeline Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Whitlash, MT Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  11. Price of Babb, MT Liquefied Natural Gas Exports to Canada (Dollars per

    Energy Information Administration (EIA) (indexed site)

    Thousand Cubic Feet) Babb, MT Liquefied Natural Gas Exports to Canada (Dollars per Thousand Cubic Feet) Price of Babb, MT Liquefied Natural Gas Exports to Canada (Dollars per Thousand Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 2010's -- 12.95 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Price

  12. Price of Buffalo, NY Liquefied Natural Gas Exports to Canada (Dollars per

    Energy Information Administration (EIA) (indexed site)

    Thousand Cubic Feet) Buffalo, NY Liquefied Natural Gas Exports to Canada (Dollars per Thousand Cubic Feet) Price of Buffalo, NY Liquefied Natural Gas Exports to Canada (Dollars per Thousand Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 2000's -- 12.07 -- -- 2010's -- -- 7.68 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date:

  13. Price of Crosby, ND Liquefied Natural Gas Exports to Canada (Dollars per

    Energy Information Administration (EIA) (indexed site)

    Thousand Cubic Feet) Crosby, ND Liquefied Natural Gas Exports to Canada (Dollars per Thousand Cubic Feet) Price of Crosby, ND Liquefied Natural Gas Exports to Canada (Dollars per Thousand Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 2010's -- 6.81 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S.

  14. ,"Niagara Falls, NY Natural Gas Pipeline Exports to Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Exports to Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Niagara Falls, NY Natural Gas Pipeline Exports to Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  15. ,"Niagara Falls, NY Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Niagara Falls, NY Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  16. ,"North Troy, VT Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Troy, VT Natural Gas Pipeline Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","North Troy, VT Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2002 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  17. ,"Noyes, MN Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Noyes, MN Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  18. ,"Pittsburg, NH Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Pittsburg, NH Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  19. ,"Port of Del Bonita, MT Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Del Bonita, MT Natural Gas Pipeline Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Port of Del Bonita, MT Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016"

  20. ,"Port of Morgan, MT Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Port of Morgan, MT Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  1. ,"Portal, ND Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Portal, ND Natural Gas Pipeline Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Portal, ND Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  2. ,"Sherwood, ND Natural Gas Pipeline Exports to Canada (Million Cubic Feet)"

    Energy Information Administration (EIA) (indexed site)

    Exports to Canada (Million Cubic Feet)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Sherwood, ND Natural Gas Pipeline Exports to Canada (Million Cubic Feet)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  3. ,"Sherwood, ND Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Sherwood, ND Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  4. ,"Sumas, WA Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Sumas, WA Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  5. ,"Sweetgrass, MT Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Sweetgrass, MT Natural Gas Pipeline Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Sweetgrass, MT Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  6. ,"U.S. Liquefied Natural Gas Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","U.S. Liquefied Natural Gas Imports From Canada (MMcf)",1,"Monthly","8/2016" ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  7. United States, Canada and Mexico Release the "North American Natural Gas

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Vision" | Department of Energy and Mexico Release the "North American Natural Gas Vision" United States, Canada and Mexico Release the "North American Natural Gas Vision" February 25, 2005 - 10:29am Addthis WASHINGTON, DC -- The North American Energy Working Group (NAEWG), a group of senior energy officials from Canada, Mexico and the United States, today released the "North American Natural Gas Vision," a trilateral report by the three governments that

  8. Highgate Springs, VT Natural Gas Liquefied Natural Gas Imports from Canada

    Energy Information Administration (EIA) (indexed site)

    (Million Cubic Feet) from Canada (Million Cubic Feet) Highgate Springs, VT Natural Gas Liquefied Natural Gas Imports from Canada (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2013 88 139 139 79 109 2014 41 23 2015 46 39 34 41 41 39 40 41 43 37 2016 41 38 43 55 110 112 64 77 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring

  9. MiR-145 is downregulated in human ovarian cancer and modulates cell growth and invasion by targeting p70S6K1 and MUC1

    SciTech Connect

    Wu, Huijuan; Xiao, ZhengHua; Wang, Ke; Liu, Wenxin; Hao, Quan

    2013-11-29

    Highlights: •MiR-145 is downregulated in human ovarian cancer. •MiR-145 targets p70S6K1 and MUC1. •p70S6K1 and MUC1 are involved in miR-145 mediated tumor cell growth and cell invasion, respectively. -- Abstract: MicroRNAs (miRNAs) are a family of small non-coding RNA molecules that regulate gene expression at post-transcriptional levels. Previous studies have shown that miR-145 is downregulated in human ovarian cancer; however, the roles of miR-145 in ovarian cancer growth and invasion have not been fully demonstrated. In the present study, Northern blot and qRT-PCR analysis indicate that miR-145 is downregulated in ovarian cancer tissues and cell lines, as well as in serum samples of ovarian cancer, compared to healthy ovarian tissues, cell lines and serum samples. Functional studies suggest that miR-145 overexpression leads to the inhibition of colony formation, cell proliferation, cell growth viability and invasion, and the induction of cell apoptosis. In accordance with the effect of miR-145 on cell growth, miR-145 suppresses tumor growth in vivo. MiR-145 is found to negatively regulate P70S6K1 and MUC1 protein levels by directly targeting their 3′UTRs. Importantly, the overexpression of p70S6K1 and MUC1 can restore the cell colony formation and invasion abilities that are reduced by miR-145, respectively. MiR-145 expression is increased after 5-aza-CdR treatment, and 5-aza-CdR treatment results in the same phenotype as the effect of miR-145 overexpression. Our study suggests that miR-145 modulates ovarian cancer growth and invasion by suppressing p70S6K1 and MUC1, functioning as a tumor suppressor. Moreover, our data imply that miR-145 has potential as a miRNA-based therapeutic target for ovarian cancer.

  10. Third Report to the President of the United States of America and the Prime Minister of Canada on

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Third Report to the President of the United States of America and the Prime Minister of Canada Submitted by: The Honorable Ernest J. Moniz The Honourable Leona Aglukkaq Secretary of Energy Minister of Environment United States of America Canada 1 CONTENTS Collaboration on Clean Energy Technology and Climate Change ................................................................. 1 Reporting on Results

  11. Blackout 2003: Energy Secretary Bodman and Minister of Natural Resources for Canada Lunn Release the 2003 Power Outage Final Report, October 3, 2006

    Energy.gov [DOE]

    Energy Secretary Bodman and Minister of Natural Resources for Canada Lunn Release the 2003 Power Outage Final Report. In accordance with the mandate of the U.S.-Canada Power Outage Task Force, the...

  12. Application to Export Electric Energy OE Docket No. EA-356-A J.P. Morgan Commodities Canada Corporation: Federal Register Notice, Volume 79, No. 59- March 27, 2014

    Energy.gov [DOE]

    Application from J.P. Morgan (JPMCCC) to export electric energy to Canada.  Federal Register Notice.

  13. The long non-coding RNA H19-derived miR-675 modulates human gastric cancer cell proliferation by targeting tumor suppressor RUNX1

    SciTech Connect

    Zhuang, Ming; Gao, Wen; Xu, Jing; Wang, Ping; Shu, Yongqian

    2014-06-06

    Graphical abstract: - Highlights: • H19 regulates gastric cancer cell proliferation phenotype via miR-675. • MiR-675 modulates cell proliferation of gastric cancer cells by targeting tumor suppressor RUNX1. • The H19/miR-675/RUNX1 axis plays an important role in the tumorigenesis of gastric cancer. - Abstract: The lncRNA H19 has been recently shown to be upregulated and play important roles in gastric cancer tumorigenesis. However, the precise molecular mechanism of H19 and its mature product miR-675 in the carcinogenesis of gastric cancer remains unclear. In this study, we found that miR-675 was positively expressed with H19 and was a pivotal mediator in H19-induced gastric cancer cell growth promotion. Subsequently, the tumor suppressor Runt Domain Transcription Factor1 (RUNX1) was confirmed to be a direct target of miR-675 using a luciferase reporter assay and Western blotting analyses. A series of rescue assays indicated that RUNX1 mediated H19/miR-67-induced gastric cancer cell phenotypic changes. Moreover, the inverse relationship between the expression of RUNX1 and H19/miR-675 was also revealed in gastric cancer tissues and gastric cancer cell lines. Taken together, our study demonstrated that the novel pathway H19/miR-675/RUNX1 regulates gastric cancer development and may serve as a potential target for gastric cancer therapy.

  14. Testing CPT conservation using the NuMI neutrino beam with the MINOS experiment

    SciTech Connect

    Auty, David John

    2010-05-01

    The MINOS experiment was designed to measure neutrino oscillation parameters with muon neutrinos. It achieves this by measuring the neutrino energy spectrum and flavor composition of the man-made NuMI neutrino beam 1km after the beam is formed and again after 735 km. By comparing the two spectra it is possible to measure the oscillation parameters. The NuMI beam is made up of 7.0% {bar {nu}}{sub {mu}}, which can be separated from the {nu}{sub {mu}} because the MINOS detectors are magnetized. This makes it possible to study {bar {nu}}{sub {mu}} oscillations separately from those of muon neutrinos, and thereby test CPT invariance in the neutrino sector by determining the {bar {nu}}{sub {mu}} oscillation parameters and comparing them with those for {nu}{sub {mu}}, although any unknown physics of the antineutrino would appear as a difference in oscillation parameters. Such a test has not been performed with beam {bar {nu}}{sub {mu}} before. It is also possible to produce an almost pure {bar {nu}}{sub {mu}} beam by reversing the current through the magnetic focusing horns of the NuMI beamline, thereby focusing negatively, instead of positively charged particles. This thesis describes the analysis of the 7% {bar {nu}}{sub {mu}} component of the forward horn current NuMI beam. The {bar {nu}}{sub {mu}} of a data sample of 3.2 x 10{sup 20} protons on target analysis found 42 events, compared to a CPT conserving prediction of 58.3{sub -7.6}{sup +7.6}(stat.){sub -3.6}{sup +3.6}(syst.) events. This corresponds to a 1.9 {sigma} deficit, and a best fit value of {Delta}{bar m}{sub 32}{sup 2} = 18 x 10{sup -3} eV{sup 2} and sin{sup 2} 2{bar {theta}}{sub 23} = 0.55. This thesis focuses particularly on the selection of {bar {nu}}{sub {mu}} events, and investigates possible improvements of the selection algorithm. From this a different selector was chosen, which corroborated the findings of the original selector. The thesis also investigates how the systematic errors affect the

  15. Unique Regulatory Approach for Licensing the Port Hope Remediation Project in Canada - 13315

    SciTech Connect

    Kostova, M.; Howard, D.; Elder, P.

    2013-07-01

    The Port Hope remediation project is a part of a larger initiative of the Canadian Federal Government the Port Hope Area Initiative (PHAI) which is based upon a community proposal. The Government of Canada, through Natural Resources Canada (NRCan) is investing $1.28 billion over 10 years to clean up historic low-level radioactive waste in the Port Hope Area and to provide long-term safe management of the low-level radioactive wastes in the Port Hope Area. These wastes arose from the activities of a former Federal Crown Corporation (Eldorado Nuclear) and its private sector predecessors. In Canada, historic waste are defined as low-level radioactive waste that was managed in a manner no longer considered acceptable, but for which the original producer cannot reasonably be held responsible or no longer exists and for which the Federal Government has accepted responsibility. In Canada, under the current regulatory framework, the environmental remediation is not considered as a distinct phase of the nuclear cycle. The regulatory approach for dealing with existing sites contaminated with radioactive residues is defined on the basis of risk and application of existing regulations. A unique regulatory approach was taken by the Canadian Nuclear Safety Commission (CNSC) to address the various licensing issues and to set out the requirements for licensing of the Port Hope Project within the current regulatory framework. (authors)

  16. [Ship-Source Oil Pollution Fund (Canada)]. Annual report, 1997--1998

    SciTech Connect

    1998-12-31

    This paper is the annual report of the Fund, established by amendment to the Canada Shipping Act in April 1989. This report presents information on new legislation, contributions to the International Oil Pollution Compensation Fund, and summaries of oil spill incidents.

  17. Assessment of radiological releases from the NuMI facility during MINOS and NOvA operations

    SciTech Connect

    Martens, Mike; /Fermilab

    2007-04-01

    This report makes projections of the radiological releases from the NuMI facility during operations for the MINOS and NO ?A experiments. It includes an estimate of the radionuclide levels released into the atmosphere and the estimated tritium and sodium-22 concentrations in the NuMI sump water and Fermilab pond system. The analysis was performed for NuMI operations with a beam power on target increased from the present 400 kW design up to a possible 1500 kW with future upgrades. The total number of protons on target was assumed to be 18 x 10{sup 20} after the completion of MINOS and 78 x 10{sup 20} after the completion of NO ?A.

  18. Identification of miR-2400 gene as a novel regulator in skeletal muscle satellite cells proliferation by targeting MYOG gene

    SciTech Connect

    Zhang, Wei Wei; Tong, Hui Li; Sun, Xiao Feng; Hu, Qian; Yang, Yu; Li, Shu Feng; Yan, Yun Qin; Li, Guang Peng

    2015-08-07

    MicroRNAs play critical roles in skeletal muscle development as well as in regulation of muscle cell proliferation and differentiation. Previous study in our laboratory showed that the expression level of miR-2400, a novel and unique miRNA from bovine, had significantly changed in skeletal muscle-derived satellite cells (MDSCs) during differentiation, however, the function and expression pattern for miR-2400 in MDSCs has not been fully understood. In this report, we firstly identified that the expression levels of miR-2400 were down-regulated during MDSCs differentiation by stem-loop RT-PCR. Over-expression and inhibition studies demonstrated that miR-2400 promoted MDSCs proliferation by EdU (5-ethynyl-2′ deoxyuridine) incorporation assay and immunofluorescence staining of Proliferating cell nuclear antigen (PCNA). Luciferase reporter assays showed that miR-2400 directly targeted the 3′ untranslated regions (UTRs) of myogenin (MYOG) mRNA. These data suggested that miR-2400 could promote MDSCs proliferation through targeting MYOG. Furthermore, we found that miR-2400, which was located within the eighth intron of the Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) gene, was down-regulated in MDSCs in a direct correlation with the WHSC1L1 transcript by Clustered regularly interspaced palindromic repeats interference (CRISPRi). In addition, these observations not only provided supporting evidence for the codependent expression of intronic miRNAs and their host genes in vitro, but also gave insight into the role of miR-2400 in MDSCs proliferation. - Highlights: • miR-2400 is a novel and unique miRNA from bovine. • miR-2400 could promote skeletal muscle satellite cells proliferation. • miR-2400 directly targeted the 3′ untranslated regions of MYOG mRNA. • miR-2400 could be coexpressed together with its host gene WHSC1L1.

  19. miR-340 inhibits glioblastoma cell proliferation by suppressing CDK6, cyclin-D1 and cyclin-D2

    SciTech Connect

    Li, Xuesong; Gong, Xuhai; Chen, Jing; Zhang, Jinghui; Sun, Jiahang; Guo, Mian

    2015-05-08

    Glioblastoma development is often associated with alteration in the activity and expression of cell cycle regulators, such as cyclin-dependent kinases (CKDs) and cyclins, resulting in aberrant cell proliferation. Recent studies have highlighted the pivotal roles of miRNAs in controlling the development and growth of glioblastoma. Here, we provide evidence for a function of miR-340 in the inhibition of glioblastoma cell proliferation. We found that miR-340 is downregulated in human glioblastoma tissue samples and several established glioblastoma cell lines. Proliferation and neurosphere formation assays revealed that miR-340 plays an oncosuppressive role in glioblastoma, and that its ectopic expression causes significant defect in glioblastoma cell growth. Further, using bioinformatics, luciferase assay and western blot, we found that miR-340 specifically targets the 3′UTRs of CDK6, cyclin-D1 and cyclin-D2, leading to the arrest of glioblastoma cells in the G0/G1 cell cycle phase. Confirming these results, we found that re-introducing CDK6, cyclin-D1 or cyclin-D2 expression partially, but significantly, rescues cells from the suppression of cell proliferation and cell cycle arrest mediated by miR-340. Collectively, our results demonstrate that miR-340 plays a tumor-suppressive role in glioblastoma and may be useful as a diagnostic biomarker and/or a therapeutic avenue for glioblastoma. - Highlights: • miR-340 is downregulated in glioblastoma samples and cell lines. • miR-340 inhibits glioblastoma cell proliferation. • miR-340 directly targets CDK6, cyclin-D1, and cyclin-D2. • miR-340 regulates glioblastoma cell proliferation via CDK6, cyclin-D1 and cyclin-D2.

  20. miR-206 is down-regulated in breast cancer and inhibits cell proliferation through the up-regulation of cyclinD2

    SciTech Connect

    Zhou, Jing; Tian, Ye; Li, Juan; Lu, Binbin; Sun, Ming; Zou, Yanfen; Kong, Rong; Luo, Yanhong; Shi, Yongguo; Wang, Keming; Ji, Guozhong

    2013-04-05

    Highlights: ? miR-206 was downexpressed in tumor samples compared with matched normal samples. ? Enhanced expression of miR-206 could inhibit breast cancer growth in vitro. ? Luciferase confirmed miR-206 functions as an anti-oncogene by targeting cyclinD2. ? A reverse correlation between miR-206 and cyclinD2 in breast cancer was found. -- Abstract: MicroRNAs act as important gene regulators in human genomes, and their aberrant expression is linked to many malignancies. Aberrant expression of miR-206 has been frequently reported in cancer studies; however, the role and mechanism of its function in breast cancer remains unclear. Quantitative real-time PCR was performed to detect the relative expression levels of miR-206 in breast cancer and normal breast tissues. Lower expression of miR-206 in breast cancer tissues was associated with larger tumour size and a more advanced clinical stage. Further in vitro observations showed that the enforced expression of miR-206 in MCF-7 breast cancer cells inhibited cell growth by blocking the G1/S transition and suppressed cell proliferation and colony formation, implying that miR-206 functions as a tumour suppressor in the progression of breast cancer. Interestingly, Luciferase assays first revealed that miR-206 inhibited cyclinD2 expression by targeting two binding sites in the 3?-untranslated region of cyclinD2 mRNA. qRT-PCR and Western blot assays verified that miR-206 reduced cyclinD2 expression at both the mRNA and protein levels. A reverse correlation between miR-206 and cyclinD2 expression was noted in breast cancer tissues. Altogether, our results identify a crucial tumour suppressive role of miR-206 in the progression of breast cancer, at least partly via up-regulation of the expression of cyclinD2, and suggest that miR-206 might be a candidate prognostic predictor or an anticancer therapeutic target for breast cancer patients.

  1. MiR-138 promotes smooth muscle cells proliferation and migration in db/db mice through down-regulation of SIRT1

    SciTech Connect

    Xu, Juan; Li, Li; Yun, Hui-fang; Han, Ye-shan

    2015-08-07

    Background: Diabetic vascular smooth muscle cells (VSMCs) exhibit significantly increased rates of proliferation and migration, which was the most common pathological change in atherosclerosis. In addition, the study about the role for miRNAs in the regulation of VSMC proliferation is just beginning to emerge and additional miRNAs involved in VSMC proliferation modulation should be identified. Methods: The expression of miR-138 and SIRT1 were examined in SMCs separated from db/db mice and in SMC lines C-12511 exposed to high glucose with qRT-PCR and western blot. The regulation of miR-138 on the expression of SMCs was detected with luciferase report assay. VSMCs proliferation and migration assays were performed to examine the effect of miR-138 inhibitor on VSMCs proliferation and migration. Results: We discovered that higher mRNA level of miR-138 and reduced expression of SIRT1 were observed in SMCs separated from db/db mice and in SMC lines C-12511. Moreover, luciferase report assay showed that the activity of SIRT1 3′-UTR was highly increased by miR-138 inhibitor and reduced by miR-138 mimic. In addition, we examined that the up-regulation of NF-κB induced by high glucose in SMCs was reversed by resveratrol and miR-138 inhibitor. MTT and migration assays showed that miR-138 inhibitor attenuated the proliferation and migration of smooth muscle cells. Conclusion: In this study, we revealed that miR-138 might promote proliferation and migration of SMC in db/db mice through suppressing the expression of SIRT1. - Highlights: • Higher mRNA level of miR-138 was observed in SMCs from db/db mice. • The mRNA and protein level of SIRT1 in SMCs from db/db mice were greatly reduced. • miR-138 could regulate the expression of SIRT1 in SMCs. • SIRT1 overexpression reversed the up-regulation of acetylized p65 and NF-κB induced by high glucose. • MiR-138 inhibitor reversed VSMCs proliferation and migration induced by high glucose.

  2. miR-15a/16 Enhances Radiation Sensitivity of Non-Small Cell Lung Cancer Cells by Targeting the TLR1/NF-κB Signaling Pathway

    SciTech Connect

    Lan, Fengming; Yue, Xiao; Ren, Gang; Li, Hongqi; Ping, Li; Wang, Yingjie; Xia, Tingyi

    2015-01-01

    Purpose: Many miRNAs have been identified as essential issues and core determining factors in tumor radiation. Recent reports have demonstrated that miRNAs and Toll-like receptors could exert reciprocal effects to control cancer development in various ways. However, a novel role of miR-15a/16 in enhancing radiation sensitivity by directly targeting TLR1 has not been reported, to our knowledge. Methods and Materials: Bioinformatic analyses, luciferase reporter assay, biochemical assays, and subcutaneous tumor establishment were used to characterize the signaling pathways of miRNA-15a/16 in response to radiation treatment. Results: First, an inverse correlation between the expression of miR-15a/16 and TLR1 protein was revealed in non-small cell lung cancer (NSCLC) and normal lung tissues. Next, we corroborated that miR-15a/16 specifically bound to TLR1 3′UTR and inhibited the expression of TLR1 in H358 and A549 cells. Furthermore, miR-15a/16 downregulated the activity of the NF-κB signaling pathway through TLR1. In addition, overexpression of miR-15a/16 inhibited survival capability and increased radiation-induced apoptosis, resulting in enhancement of radiosensitivity in H358 and A549 cells. Finally, subcutaneous tumor bearing NSCLC cells in a nude mice model was established, and the results showed that combined groups (miR-15a/16 + radiation) inhibited tumor growth more significantly than did radiation alone. Conclusions: We mainly elucidate that miRNA-15a/16 can enhance radiation sensitivity by regulating the TLR1/NF-κB signaling pathway and act as a potential therapeutic approach to overcome radioresistance for lung cancer treatment.

  3. Nafta due to end most barriers to trade among U. S. , Mexico, Canada

    SciTech Connect

    Not Available

    1992-08-24

    This paper reports that energy companies in the U.S. will benefit --- but not as much as they had hoped --- from the recently drafted North American Free Trade Agreement (Nafta) among the U.S., Mexico, and Canada. Nafta would remove most of the trade barriers between Mexico and the other two countries and supplement the U.S. - Canada Free Trade Agreement to create an open market in North America totaling $6 trillion/year in products and serving more than 360 million persons. Nafta was negotiated under a law that allows Congress to consider the pact for only 90 days, then vote on it without amendments. The pact marks the first time the U.S. has covered environmental concerns in a trade treaty, mainly pollution along the U.S.-Mexico border. The pact also is consistent with the international General Agreement on Tariffs and Trade (GATT).

  4. Revenue surge to sustain drilling in U.S. and Canada

    SciTech Connect

    Beck, R.J.; Petzet, G.A.

    1997-01-27

    Drilling activity in the US and Canada will remain strong in 1997 after increasing in 1996. Oil and Gas Journal figures indicate that rising oil and gas prices provided operators during 1996 with their highest wellhead revenues since 1985. This portends robust capital and exploration spending as long as operators follow through with plans revealed in recent weeks. Also encouraging operators to boost drilling programs are economically juicy plays in the Gulf of Mexico, Gulf Coast, and several other onshore areas. A group of major oil companies indicated plans to increase US exploratory drilling this year against a slight dip in total US drilling. And Canada is matching or exceeding forecasters` expectations, with no letup in view from its last few years` pace of 11,000--12,000 wells/year. The paper discusses US economics, year to year performance, activities of the major oil companies, and Canadian activities.

  5. Liquefied U.S. Natural Gas Exports to Canada (Million Cubic Feet)

    Energy Information Administration (EIA) (indexed site)

    Canada (Million Cubic Feet) Liquefied U.S. Natural Gas Exports to Canada (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2007 2 2008 0 0 0 0 0 0 0 0 0 0 0 0 2009 0 0 0 0 0 0 0 0 0 0 0 0 2010 0 0 0 0 0 0 0 0 0 0 0 0 2011 0 0 0 0 0 0 0 0 0 0 0 0 2012 2 2013 3 5 4 6 9 8 5 8 7 5 7 5 2014 8 12 11 9 9 7 7 7 6 7 7 8 2015 6 4 6 6 6 6 5 0 2 0 1 0 2016 2 0 0 0 0 0 0 0 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual

  6. Blackout 2003: U.S.- Canada Task Force Presents Final Report onBlackout of August 2003

    Energy.gov [DOE]

    August 14, 2003, saw the worst blackout in North American history. Today, Spencer Abraham, U.S. Secretary of Energy, and the Honorable R. John Efford, Minister of Natural Resources Canada, released...

  7. Energy Secretary Bodman and Minister of Natural Resources for Canada Lunn Release the 2003 Power Outage Final Report

    Energy.gov [DOE]

    U.S. Department of Energy Secretary Samuel W. Bodman and Minister of Natural Resources for Canada Gary Lunn, today released the final report on the power outage that affected 50 million North Americans in August 2003.

  8. Energy Secretary Bodman and Minister of Natural Resources for Canada Lunn Release the 2003 Power Outage Final Report

    Energy.gov [DOE]

    WASHINGTON, D.C. - U.S. Department of Energy Secretary Samuel W. Bodman and Minister of Natural Resources for Canada Gary Lunn, today released the final report on the power outage that affected 50...

  9. Expander-gas processing plant converted to boost C3 recovery at Canada's Judy Creek

    SciTech Connect

    Khan, S.A.

    1985-06-03

    This article discusses Esso Resources Canada Ltd's conversion of its Judy Creek cryogenic expander gas plant in Alberta to a process which can boost recovery of propane and heavier hydrocarbons. After conversion, propane recovery at the plant increased from 72% to 95%. At constant plant feed rates, 100% propane recovery has been recorded. The total investment for the conversion, less than $750,000, was paid out in under 6 months.

  10. Observation of Disappearance of Muon Neutrinos in the NuMI Beam

    SciTech Connect

    Pavlovic, Zarko

    2008-05-01

    The Main Injector Neutrino Oscillation Search (MINOS) is a two detector long-baseline neutrino experiment designed to study the disappearance of muon neutrinos. MINOS will test the vμ → vτ oscillation hypothesis and measure precisely Δm232 and sin223 oscillation parameters. The source of neutrinos for MINOS experiment is Fermilab's Neutrinos at the Main Injector (NuMI) beamline. The energy spectrum and the composition of the beam is measured at two locations, one close to the source and the other 735 km down-stream in the Soudan Mine Underground Laboratory in northern Minnesota. The precision measurement of the oscillation parameters requires an accurate prediction of the neutrino flux at the Far Detector. This thesis discusses the calculation of the neutrino flux at the Far Detector and its uncertainties. A technique that uses the Near Detector data to constrain the uncertainties in the calculation of the flux is described. The data corresponding to an exposure of 2.5 x 1020 protons on the NuMI target is presented and an energy dependent disappearance pattern predicted by neutrino oscillation hypotheses is observed in the Far Detector data. The fit to MINOS data, for given exposure, yields the best fit values for Δm$2\\atop{23}$ and sin223 to be (2.38$+0.20\\atop{-0.16}$) x 10-3 eV2/c4and 1.00-0.08, respectively.

  11. Validation of the MCNPX-PoliMi Code to Design a Fast-Neutron Multiplicity Counter

    SciTech Connect

    J. L. Dolan; A. C. Kaplan; M. Flaska; S. A. Pozzi; D. L. Chichester

    2012-07-01

    Many safeguards measurement systems used at nuclear facilities, both domestically and internationally, rely on He-3 detectors and well established mathematical equations to interpret coincidence and multiplicity-type measurements for verifying quantities of special nuclear material. Due to resource shortages alternatives to these existing He-3 based systems are being sought. Work is also underway to broaden the capabilities of these types of measurement systems in order to improve current multiplicity analysis techniques. As a part of a Material Protection, Accounting, and Control Technology (MPACT) project within the U.S. Department of Energy's Fuel Cycle Technology Program we are designing a fast-neutron multiplicity counter with organic liquid scintillators to quantify important quantities such as plutonium mass. We are also examining the potential benefits of using fast-neutron detectors for multiplicity analysis of advanced fuels in comparison with He-3 detectors and testing the performance of such designs. The designs are being developed and optimized using the MCNPX-PoliMi transport code to study detector response. In the full paper, we will discuss validation measurements used to justify the use of the MCNPX-PoliMi code paired with the MPPost multiplicity routine to design a fast neutron multiplicity counter with liquid scintillators. This multiplicity counter will be designed with the end goal of safeguarding advanced nuclear fuels. With improved timing qualities associated with liquid scintillation detectors, we can design a system that is less limited by nuclear materials of high activities. Initial testing of the designed system with nuclear fuels will take place at Idaho National Laboratory in a later stage of this collaboration.

  12. T-1025 IU SciBath-768 detector tests in MI-12

    SciTech Connect

    Tayloe, Rex; Cooper, R.; Garrison, L.; Thornton, T.; Rebenitsch, L.; DeJongh, Fritz; Loer, Benjamin; Ramberg, Erik; Yoo, Jonghee; /Fermilab

    2012-02-11

    This is a memorandum of understanding between the Fermi National Accelerator Laboratory (Fermilab) and the experimenters of Department of Physics and Center for Exploration of Energy and Matter, Indiana University, who have committed to participate in detector tests to be carried out during the 2012 Fermilab Neutrino program. The memorandum is intended solely for the purpose of recording expectations for budget estimates and work allocations for Fermilab, the funding agencies and the participating institutions. it reflects an arrangement that currently is satisfactory to the parties; however, it is recognized and anticipated that changing circumstances of the evolving research program will necessitate revisions. The parties agree to modify this memorandum to reflect such required adjustments. Actual contractual obligations will be set forth in separate documents. The experimenters propsoe to test their prototype 'SciBat-768' detector in the MI-12 building for 3 months (February-April) in Spring 2012. The major goal of this effort is to measure or limit the flux of beam-induced neutrons in a far-off-axis (> 45{sup o}) location of the Booster Neutrino Beamline (BNB). This flux is of interest for a proposed coherent neutral-current neutrino-argon elastic scattering experiment. A second goal is to collect more test data for the SciBath-768 to enable better understanding and calibration of the device. The SciBath-768 detector successfully ran for 3 months in the MINOS Underground Area in Fall 2011 as testbeam experiment T-1014 and is currently running above ground in the MINOS service building. For the run proposed here, the experiments are requesting: space in MI-12 in which to run the SciBath detector during February-April 2012 while the BNB is operating; technical support to help with moving the equipment on site; access to power, internet, and accelerator signals; and a small office space from which to run and monitor the experiment.

  13. MiR-520b suppresses proliferation of hepatoma cells through targeting ten-eleven translocation 1 (TET1) mRNA

    SciTech Connect

    Zhang, Weiying; Lu, Zhanping; Gao, Yuen; Ye, Lihong; Song, Tianqiang; Zhang, Xiaodong

    2015-05-08

    Accumulating evidence indicates that microRNAs are able to act as oncogenes or tumor suppressor genes in human cancer. We previously reported that miR-520b was down-regulated in hepatocellular carcinoma (HCC) and its deregulation was involved in hepatocarcinogenesis. In the present study, we report that miR-520b suppresses cell proliferation in HCC through targeting the ten-eleven translocation 1 (TET1) mRNA. Notably, we identified that miR-520b was able to target 3′-untranslated region (3′UTR) of TET1 mRNA by luciferase reporter gene assays. Then, we revealed that miR-520b was able to reduce the expression of TET1 at the levels of mRNA and protein using reverse transcription-polymerase chain reaction and Western blotting analysis. In terms of function, 5-ethynyl-2-deoxyuridine (EdU) incorporation and colony formation assays demonstrated that the forced miR-520b expression remarkably inhibited proliferation of hepatoma cells, but TET1 overexpression could rescue the inhibition of cell proliferation mediated by miR-520b. Furthermore, anti-miR-520b enhanced proliferation of hepatoma cells, whereas silencing of TET1 abolished anti-miR-520b-induced acceleration of cell proliferation. Then, we validated that the expression levels of miR-520b were negatively related to those of TET1 mRNA in clinical HCC tissues. Thus, we conclude that miR-520b depresses proliferation of liver cancer cells through targeting 3′UTR of TET1 mRNA. Our finding provides new insights into the mechanism of hepatocarcinogenesis. - Highlights: • TET1 is a novel target gene of miR-520b. • TET1 is upregulated in clinical HCC tissues. • MiR-520b is negatively correlated with TET1 in clinical HCC tissues. • MiR-520b depresses the proliferation of HCC cells through targeting TET1 mRNA.

  14. Buildings*","Northeast",,"Midwest",,"South",,,"West"

    Energy Information Administration (EIA) (indexed site)

    ... of Hot Water ......",567,30,63,80,55,111,39,56,47,86 "Separate Computer Area ......",553,29,69,84,51,104,29,57,37,93 "HVAC Conservation Features" "(more than one may apply)" ...

  15. DOE Recognizes Midwest Industrial Efficiency Leaders | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    began last night and continued today, Governor Granholm and DOE announced 11 Save Energy Now awards recognizing industry leaders for their exemplary energy saving accomplishments. ...

  16. Midwest Energy Inc | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Inc Address: 1330 Canterbury Road Place: Hays, Kansas Zip: 67601 Product: Electricity Natural Gas Number of Employees: 201-500 Phone Number: 785-625-3437 Website:...

  17. Midwest Region Combined Heat and Power Projects

    Energy.gov [DOE]

    DOE's CHP Technical Assistance Partnerships (CHP TAPs) have compiled a select number of combined heat and power (CHP) project profiles, which are available as Adobe Acrobat PDFs. 

  18. PROJECT PROFILE: Midwest Renewable Energy Association (Solar...

    Office of Environmental Management (EM)

    This effort showcases the potential of university solar photovoltaic (PV) investments, advances favorable board policies to govern PV investments, and provides a roadmap for ...

  19. Clean Energy Manufacturing Initiative Midwest Regional Summit...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Breakout Session Summary (372.05 KB) More Documents & Publications Fiber Reinforced Polymer Composite Manufacturing Workshop Multimaterial Joining Workshop Manufacturing ...

  20. Midwest Electric Member Corp | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    EIA Form EIA-861 Final Data File for 2010 - File1a1 Energy Information Administration Form 8262 EIA Form 861 Data Utility Id 12539 Utility Location Yes Ownership C...

  1. Midwest Regional Carbon Sequestration Partnership-Validation...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... State Museum Institute Ohio Coal Development Office within ... Specifically, the MRCSP demonstrated the safety and ... Mining operations ceased at different times for each of the ...

  2. Buildings","Northeast",,"Midwest",,"South",,,"West"

    Energy Information Administration (EIA) (indexed site)

    ...3,47,202,90,203,69,139 "Building Shell Conservation" "Features (more than one" "may ...30,97,168,96,195,114,199,138,245 "HVAC Conservation Features" "(more than one may apply)" ...

  3. Buildings","Northeast",,"Midwest",,"South",,,"West"

    Energy Information Administration (EIA) (indexed site)

    ...37,1576,2276,1009,2405 "Building Shell Conservation" "Features (more than one" "may ...34,2130,5279,2330,3637,2337,5443 "HVAC Conservation Features" "(more than one may apply)" ...

  4. Midwest Forensics Resource Center | The Ames Laboratory

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    (shot sequence, direction of fire, etc.); examination of the projectile penetration, perforation, and deflection characteristics of: sheet metal, glass, wall materials, wood,...

  5. Clean Energy Manufacturing Initiative Midwest Regional Summit...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ... studies for multi-material joining Joining and corrosion ... A cumbersome process for producing ... stamping operations used with other material systems Aluminum forming ...

  6. Midwest (PADD 2) Weekly Inputs & Utilization

    Gasoline and Diesel Fuel Update

    M068(2011) The Electricity Market Module of the National Energy Modeling System Model Documentation Report July 2011 U.S. Energy Information Administration Office of Integrated Analysis and Forecasting U.S. Department of Energy Washington, DC 20585 ii U.S. Energy Information Administration/Electricity Market Module Documentation Contacts This report was prepared by the staff of the Office of Electricity, Coal, Nuclear and Renewables Analysis, U.S. Energy Information Administration. General

  7. Midwest Renewable Energy LLC | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Renewable Energy LLC Place: Sutherland, Nebraska Zip: 69165 Product: 25mmgy (94.6m litrey) ethanol producer. Coordinates: 37.19651, -77.561418 Show Map Loading map......

  8. The influence of coyotes on an urban Canada goose population in the Chicago metropolitan area

    SciTech Connect

    Brown, Justin L.; /Ohio State U.

    2007-01-01

    Canada geese (Branta canadensis) have become common in many urban areas, often creating nuisance problems for human residents. The presence of urban geese has raised concerns about the spread of disease, increased erosion, excessive noise, eutrophication of waterways, and general nuisance problems. Goose populations have grown due to an increase in urbanization resulting in an abundance of high quality food (urban grass) and suitable nesting sites, as well as a decrease in some predators. I monitored nest predation in the Chicago suburbs during the 2004 and 2005 nesting seasons using 3 nest monitoring techniques to identify predators: video cameras, plasticine eggs, and sign from nest using a classification tree analysis. Of 58 nests monitored in 2004 and 286 in 2005, only raccoons (Procyon lotor) and coyotes (Canis latrans) were identified as nest predators. Raccoons were responsible for 22-25% of depredated nests, but were rarely capable of depredating nests that were actively defended by a goose. Coyotes were responsible for 75-78% of all Canada goose nest depredation and were documented killing one adult goose and feeding on several others. The coyote is a top-level predator that had increased in many metropolitan areas in recent years. To determine if coyotes were actively hunting geese or eggs during the nesting season, I analyzed coyote habitat selection between nesting and pre-nesting or post-nesting seasons. Coyote home ranges (95% Minimum Convex Polygon) were calculated for 19 coyotes to examine third order habitat selection related to goose nest abundance. A 100 m buffer (buffer habitat) was created and centered on each waterway edge and contained 90% of all nests. Coyotes showed selection for habitats during all seasons. Buffer habitat was the top ranked habitat in both pre-nesting and nesting seasons, but dropped to third ranked in post-nesting season. Habitat selection across seasons was compared using a repeated measures MANOVA. Habitat selection

  9. Fact #832: August 4, 2014 Over Half of the Refueling Stations in the U.S. and Canada Sell Diesel Fuel- Dataset

    Energy.gov [DOE]

    Excel file with dataset for Fact #832: Over Half of the Refueling Stations in the U.S. and Canada Sell Diesel Fuel

  10. 275px-Lap_1%2C_Turn_1_Canada_2008_0.jpg | OSTI, US Dept of Energy Office of

    Office of Scientific and Technical Information (OSTI)

    Scientific and Technical Information 275px-Lap_1%2C_Turn_1_Canada_2008_0.jpg

  11. Annual bulletin of coal statistics for Europe-1983. [Europe, Canada, USA, USSR

    SciTech Connect

    Not Available

    1985-01-01

    This is a series of statistical tables documenting the production, trade, and consumption of coal in Europe, Canada, the United States, and the Soviet Union. Balance sheets of solid forms of energy are provided for hard coal, patent fuel, and coke; and for brown coal, brown coal briquettes, and brown coal coke. Data are provided on hard coal mines and on brown coal mines for production, employment and productivity of labor. Other tables list imports of solid fuels by country, exports of solid fuels by country, and world production of solid fuels.

  12. Havre, MT Natural Gas Pipeline Imports From Canada (Dollars per Thousand

    Energy Information Administration (EIA) (indexed site)

    Cubic Feet) Dollars per Thousand Cubic Feet) Havre, MT Natural Gas Pipeline Imports From Canada (Dollars per Thousand Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's NA NA 2000's 3.66 NA NA -- - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Price of

  13. Integrated Canada-U.S. Power Sector Modeling with the Regional Energy Deployment System (ReEDS)

    SciTech Connect

    Martinez, A.; Eurek, K.; Mai, T.; Perry, A.

    2013-02-01

    The electric power system in North America is linked between the United States and Canada. Canada has historically been a net exporter of electricity to the United States. The extent to which this remains true will depend on the future evolution of power markets, technology deployment, and policies. To evaluate these and related questions, we modify the Regional Energy Deployment System (ReEDS) model to include an explicit representation of the grid-connected power system in Canada to the continental United States. ReEDS is unique among long-term capacity expansion models for its high spatial resolution and statistical treatment of the impact of variable renewable generation on capacity planning and dispatch. These unique traits are extended to new Canadian regions. We present example scenario results using the fully integrated Canada-U.S. version of ReEDS to demonstrate model capabilities. The newly developed, integrated Canada-U.S. ReEDS model can be used to analyze the dynamics of electricity transfers and other grid services between the two countries under different scenarios.

  14. The RNA-binding protein PCBP2 facilitates gastric carcinoma growth by targeting miR-34a

    SciTech Connect

    Hu, Cheng-En; Liu, Yong-Chao; Zhang, Hui-Dong; Huang, Guang-Jian

    2014-06-13

    Highlights: • PCBP2 is overexpressed in human gastric cancer. • PCBP2 high expression predicts poor survival. • PCBP2 regulates gastric cancer growth in vitro and in vivo. • PCBP2 regulates gastric cancer apoptosis by targeting miR-34a. - Abstract: Gastric carcinoma is the fourth most common cancer worldwide, with a high rate of death and low 5-year survival rate. However, the mechanism underling gastric cancer is still not fully understood. Here in the present study, we identify the RNA-binding protein PCBP2 as an oncogenic protein in human gastric carcinoma. Our results show that PCBP2 is up-regulated in human gastric cancer tissues compared to adjacent normal tissues, and that high level of PCBP2 predicts poor overall and disease-free survival. Knockdown of PCBP2 in gastric cancer cells inhibits cell proliferation and colony formation in vitro, whereas opposing results are obtained when PCBP2 is overexpressed. Our in vivo subcutaneous xenograft results also show that PCBP2 can critically regulate gastric cancer cell growth. In addition, we find that PCBP2-depletion induces apoptosis in gastric cancer cells via up-regulating expression of pro-apoptotic proteins and down-regulating anti-apoptotic proteins. Mechanically, we identify that miR-34a as a target of PCBP2, and that miR-34a is critically essential for the function of PCBP2. In summary, PCBP2 promotes gastric carcinoma development by regulating the level of miR-34a.

  15. Ginsenoside-Rg{sub 1} induces angiogenesis by the inverse regulation of MET tyrosine kinase receptor expression through miR-23a

    SciTech Connect

    Kwok, Hoi-Hin; Chan, Lai-Sheung; Poon, Po-Ying; Yue, Patrick Ying-Kit; Wong, Ricky Ngok-Shun

    2015-09-15

    Therapeutic angiogenesis has been implicated in ischemic diseases and wound healing. Ginsenoside-Rg{sub 1} (Rg{sub 1}), one of the most abundant active components of ginseng, has been demonstrated as an angiogenesis-stimulating compound in different models. There is increasing evidence implicating microRNAs (miRNAs), a group of non-coding RNAs, as important regulators of angiogenesis, but the role of microRNAs in Rg{sub 1}-induced angiogenesis has not been fully explored. In this report, we found that stimulating endothelial cells with Rg{sub 1} could reduce miR-23a expression. In silico experiments predicted hepatocyte growth factor receptor (MET), a well-established mediator of angiogenesis, as the target of miR-23a. Transfection of the miR-23a precursor or inhibitor oligonucleotides validated the inverse relationship of miR-23a and MET expression. Luciferase reporter assays further confirmed the interaction between miR-23a and the MET mRNA 3′-UTR. Intriguingly, ginsenoside-Rg{sub 1} was found to increase MET protein expression in a time-dependent manner. We further demonstrated that ginsenoside-Rg{sub 1}-induced angiogenic activities were indeed mediated through the down-regulation of miR-23a and subsequent up-regulation of MET protein expression, as confirmed by gain- and loss-of-function angiogenic experiments. In summary, our results demonstrated that ginsenoside-Rg{sub 1} could induce angiogenesis by the inverse regulation of MET tyrosine kinase receptor expression through miR-23a. This study has broadened our understanding of the non-genomic effects of ginsenoside-Rg{sub 1,} and provided molecular evidence that warrant further development of natural compound as novel angiogenesis-promoting therapy. - Highlights: • Therapeutic angiogenesis has been implicated in ischemic diseases and wound healing. • Ginsenoside-Rg{sub 1} (Rg{sub 1}) has been demonstrated as an angiogenesis-stimulating compound. • We found that Rg{sub 1} induces angiogenesis by

  16. Analysis of the hydraulic data from the MI fracture zone at the Grimsel Rock Laboratory, Switzerland

    SciTech Connect

    Davey, A.; Karasaki, K.; Long, J.C.S.; Landsfeld, M.; Mensch, A.; Martel, S.J.

    1989-10-01

    One of the major problems in analyzing flow and transport in fractured rock is that the flow may be largely confined to a poorly connected network of fractures. In order to overcome some of this problem, Lawrence Berkeley Laboratory (LBL) has been developing a new type of fracture hydrology model called an equivalent discontinuum model. In this model the authors represent the discontinuous nature of the problem through flow on a partially filled lattice. A key component in constructing an equivalent discontinuum model from this lattice is removing some of the conductive elements such that the system is partially connected in the same manner as the fracture network. This is done through a statistical inverse technique called simulated annealing. The fracture network model is annealed by continually modifying a base model, or template such that the modified systems behave more and more like the observed system. In order to see how the simulated annealing algorithm works, the authors have developed a series of synthetic real cases. In these cases, the real system is completely known so that the results of annealing to steady state data can be evaluated absolutely. The effect of the starting configuration has been studied by varying the percent of conducting elements in the initial configuration. Results have shown that the final configurations converge to about the same percentage of conducting elements. An example using Nagra field data from the Migration Experiment (MI) at Grimsel Rock Laboratory in Switzerland is also analyzed. 24 refs., 33 figs., 3 tabs.

  17. A Flexible Baseline Design for the Advanced High Temperature Reactor Using Metallic Internals (AHTR-MI)

    SciTech Connect

    Peterson, Per F.; Haihua, Zhao

    2006-07-01

    The Advanced High Temperature Reactor (AHTR) is a novel reactor concept that uses clean liquid fluoride salts as a high temperature primary coolant for conventional graphite matrix, coated particle fuels. The very large volumetric heat capacity and excellent natural circulation heat transfer provided by liquid salts enables the design of high-temperature reactors with passive safety features and thermal powers ranging from 2400 to 4000 MW(t). To make optimal use of existing design information, early AHTR designs were modeled upon the S-PRISM sodium pool-reactor design, but introduced an insulated reactor vessel. Subsequent work has shown that liquid-salt cooled systems share important similarities with pressurized water reactors, which use a closed primary loop. This article discusses the use of a closed primary loop immersed in a separate buffer salt tank, which permits the primary loop components to be fabricated from metallic materials (AHTR-MI). This approach may provide several key advantages over open loop approaches, including very large thermal inertia. (authors)

  18. Port Radium Canada's Original Radium/Uranium Mine, The Complete Story of Canada's Historic Radium/Uranium Mine, 1932 to 2012 - 13159

    SciTech Connect

    Chambers, Doug; Wiatzka, Gerd; Brown, Steve

    2013-07-01

    This paper provides the life story of Canada's original radium/uranium mine. In addition to the history of operations, it discusses the unique and successful approach used to identify the key issues and concerns associated with the former radium, uranium and silver mining property and the activities undertaken to define the remedial actions and subsequent remedial plan. The Port Radium Mine site, situated approximately 275 km north of Yellowknife on the east shore of Great Bear Lake, Northwest Territories, was discovered in 1930 and underground mining began in 1932. The mine operated almost continuously from 1932 to 1982, initially for recovery of radium, then uranium and finally, for recovery of silver. Tailings production totaled an estimated 900,000 tons and 800,000 tons from uranium and silver processing operations respectively. In the early days of mining, Port Radium miners were exposed to radon and associated decay product levels (in Working Level Months of exposure - WLM) hundreds of times greater than modern standards. The experience of the Port Radium miners provides important contribution to understanding the risks from radon. While the uranium mine was originally decommissioned in the early 1960's, to the standards of the day, the community of Deline (formerly Fort Franklin) had concerns about residual contamination at the mine site and the potential effects arising from use of traditional lands. The Deline people were also concerned about the possible risks to Deline Dene arising from their work as ore carriers. In the late 1990's, the community of Deline brought these concerns to national attention and consequently, the Government of Canada and the community of Deline agreed to move forward in a collaborative manner to address these concerns. The approach agreed to was to establish the Canada-Deline Uranium Table (CDUT) to provide a joint process by which the people of Deline could have their concerns expressed and addressed. A great deal of work was

  19. Monocyte to macrophage differentiation-associated (MMD) targeted by miR-140-5p regulates tumor growth in non-small cell lung cancer

    SciTech Connect

    Li, Weina; He, Fei

    2014-07-18

    Highlights: • Expression of MMD is increased in lung cancer tissues. • Knockdown of MMD inhibits growth of A549 and LLC cells in vitro and in vivo. • MMD is a direct functional target of miR-140-5p. • MiR-140-5p/MMD axis regulates Erk1/2 signaling. - Abstract: Monocyte to macrophage differentiation-associated (MMD) is identified in macrophages as a gene associated with the differentiation from monocytes to macrophages. Recent microarray analysis for non-small cell lung cancer (NSCLC) suggests that MMD is an important signature associated with relapse and survival among patients with NSCLC. Therefore, we speculate that MMD likely plays a role in lung cancer. In this study, we found that the protein level of MMD was increased in lung cancer compared to benign lung tissues, and knockdown of MMD inhibited the growth of A549 and Lewis lung cancer cells (LLC) in vitro and in vivo. Integrated analysis demonstrated that MMD was a direct functional target of miR-140-5p. Furthermore, we found that miR-140-5p/MMD axis could affect the cell proliferation of lung cancer cells by regulating Erk signaling. Together, our results highlight the significance of miR-140-5p/MMD axis in lung cancer, and miR-140-5p/MMD axis could serve as new molecular targets for the therapy against lung cancer.

  20. Canada's Deep Geological Repository for Used Nuclear Fuel - Geo-scientific Site Evaluation Process - 13117

    SciTech Connect

    Blyth, Alec; Ben Belfadhel, Mahrez; Hirschorn, Sarah; Hamilton, Duncan; McKelvie, Jennifer

    2013-07-01

    The Nuclear Waste Management Organization (NWMO) is responsible for implementing Adaptive Phased Management (APM), the approach selected by the Government of Canada for long-term management of used nuclear fuel generated by Canadian nuclear reactors. The ultimate objective of APM is the centralized containment and isolation of Canada's used nuclear fuel in a Deep Geological Repository in a suitable rock formation at a depth of approximately 500 meters (m) (1,640 feet [ft]). In May 2010, the NWMO published a nine-step site selection process that serves as the road map to decision-making on the location for the deep geological repository. The safety and appropriateness of any potential site will be assessed against a number of factors, both technical and social in nature. The selected site will be one that can be demonstrated to be able to safely contain and isolate used nuclear fuel, protecting humans and the environment over the very long term. The geo-scientific suitability of potential candidate sites will be assessed in a stepwise manner following a progressive and thorough site evaluation process that addresses a series of geo-scientific factors revolving around five safety functions. The geo-scientific site evaluation process includes: Initial Screenings; Preliminary Assessments; and Detailed Site Evaluations. As of November 2012, 22 communities have entered the site selection process (three in northern Saskatchewan and 18 in northwestern and southwestern Ontario). (authors)

  1. United States-Canada air services: The role of alliances in a future bilateral agreement

    SciTech Connect

    Lewis, I.

    1995-12-01

    Transborder air services between the U.S. and Canada represent a mixing of two dynamic domestic markets whose relationships with each other is governed by a diplomatically negotiated agreement between governments. Trying to divide up the pie between the carriers of both nations while promoting economic growth is proving to be very difficult; four years of negotiations have yet to reach fruition. The Canadian government and carriers see the pie as fixed; there is only so much transborder traffic and Canadian airlines need their share. In contrast, U.S. carriers, airport operators, and government negotiators see the airline industry as a major instrument of economic growth. In this view, they are joined by many Canadian communities who believe that increased service can be of considerable benefit. More competition and better service can only lead to higher demand and passenger volume, from which Canadian airlines will benefit. Alliances between U.S. and Canadian carriers can help break the deadlock. The two governments need to recognize that their domestic airline industries are not distinct, and that they will share in any liberalization. Alliances need formal recognition, encouragement, and may be one of the few viable instruments available that will promote a greatly needed bilateral air services agreement between the U.S. and Canada.

  2. Sci—Thur PM: Imaging — 06: Canada's National Computed Tomography (CT) Survey

    SciTech Connect

    Wardlaw, GM; Martel, N; Blackler, W; Asselin, J-F

    2014-08-15

    The value of computed tomography (CT) in medical imaging is reflected in its' increased use and availability since the early 1990's; however, given CT's relatively larger exposures (vs. planar x-ray) greater care must be taken to ensure that CT procedures are optimised in terms of providing the smallest dose possible while maintaining sufficient diagnostic image quality. The development of CT Diagnostic Reference Levels (DRLs) supports this process. DRLs have been suggested/supported by international/national bodies since the early 1990's and widely adopted elsewhere, but not on a national basis in Canada. Essentially, CT DRLs provide guidance on what is considered good practice for common CT exams, but require a representative sample of CT examination data to make any recommendations. Canada's National CT Survey project, in collaboration with provincial/territorial authorities, has collected a large national sample of CT practice data for 7 common examinations (with associated clinical indications) of both adult and pediatric patients. Following completion of data entry into a common database, a survey summary report and recommendations will be made on CT DRLs from this data. It is hoped that these can then be used by local regions to promote CT practice optimisation and support any dose reduction initiatives.

  3. Executive summary of major NuMI lessons learned: a review of relevant meetings of Fermilab's DUSEL Beamline Working Group

    SciTech Connect

    Andrews, Mike; Appel, Jeffrey A.; Bogert, Dixon; Childress, Sam; Cossairt, Don; Griffing, William; Grossman, Nancy; Harding, David; Hylen, Jim; Kuchler, Vic; Laughton, Chris; /Fermilab /Argonne /Brookhaven /LBL, Berkeley

    2009-05-01

    We have gained tremendous experience with the NuMI Project on what was a new level of neutrino beams from a high power proton source. We expect to build on that experience for any new long baseline neutrino beam. In particular, we have learned about some things which have worked well and/or where the experience is fairly directly applicable to the next project (e.g., similar civil construction issues including: tunneling, service buildings, outfitting, and potential claims/legal issues). Some things might be done very differently (e.g., decay pipe, windows, target, beam dump, and precision of power supply control/monitoring). The NuMI experience does lead to identification of critical items for any future such project, and what issues it will be important to address. The DUSEL Beamline Working Group established at Fermilab has been meeting weekly to collect and discuss information from that NuMI experience. This document attempts to assemble much of that information in one place. In this Executive Summary, we group relevant discussion of some of the major issues and lessons learned under seven categories: (1) Differences Between the NuMI Project and Any Next Project; (2) The Process of Starting Up the Project; (3) Decision and Review Processes; (4) ES&H: Environment, Safety, and Health; (5) Local Community Buy-In; (6) Transition from Project Status to Operation; and (7) Some Lessons on Technical Elements. We concentrate here on internal project management issues, including technical areas that require special attention. We cannot ignore, however, two major external management problems that plagued the NuMI project. The first problem was the top-down imposition of an unrealistic combination of scope, cost, and schedule. This situation was partially corrected by a rebaselining. However, the full, desirable scope was never achievable. The second problem was a crippling shortage of resources. Critical early design work could not be done in a timely fashion, leading to

  4. ,"Price of U.S. Liquefied Natural Gas Imports From Canada (Dollars per Thousand Cubic Feet)"

    Energy Information Administration (EIA) (indexed site)

    Canada (Dollars per Thousand Cubic Feet)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Price of U.S. Liquefied Natural Gas Imports From Canada (Dollars per Thousand Cubic Feet)",1,"Monthly","8/2016" ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016"

  5. ,"Price of U.S. Natural Gas Pipeline Imports From Canada (Dollars per Thousand Cubic Feet)"

    Energy Information Administration (EIA) (indexed site)

    Canada (Dollars per Thousand Cubic Feet)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Price of U.S. Natural Gas Pipeline Imports From Canada (Dollars per Thousand Cubic Feet)",1,"Monthly","8/2016" ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016"

  6. Hepatitis B virus X protein mutant HBxΔ127 promotes proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT

    SciTech Connect

    Liu, Fabao; You, Xiaona; Chi, Xiumei; Wang, Tao; Ye, Lihong; Niu, Junqi; Zhang, Xiaodong

    2014-02-07

    Highlights: • Relative to wild type HBx, HBX mutant HBxΔ127 strongly enhances cell proliferation. • Relative to wild type HBx, HBxΔ127 remarkably up-regulates miR-215 in hepatoma cells. • HBxΔ127-elevated miR-215 promotes cell proliferation via targeting PTPRT mRNA. - Abstract: The mutant of virus is a frequent event. Hepatitis B virus X protein (HBx) plays a vital role in the development of hepatocellular carcinoma (HCC). Therefore, the identification of potent mutant of HBx in hepatocarcinogenesis is significant. Previously, we identified a natural mutant of the HBx gene (termed HBxΔ127). Relative to wild type HBx, HBxΔ127 strongly enhanced cell proliferation and migration in HCC. In this study, we aim to explore the mechanism of HBxΔ127 in promotion of proliferation of hepatoma cells. Our data showed that both wild type HBx and HBxΔ127 could increase the expression of miR-215 in hepatoma HepG2 and H7402 cells. However, HBxΔ127 was able to significantly increase miR-215 expression relative to wild type HBx in the cells. We identified that protein tyrosine phosphatase, receptor type T (PTPRT) was one of the target genes of miR-215 through targeting 3′UTR of PTPRT mRNA. In function, miR-215 was able to promote the proliferation of hepatoma cells. Meanwhile anti-miR-215 could partially abolish the enhancement of cell proliferation mediated by HBxΔ127 in vitro. Knockdown of PTPRT by siRNA could distinctly suppress the decrease of cell proliferation mediated by anti-miR-215 in HepG2-XΔ127/H7402-XΔ127 cells. Moreover, we found that anti-miR-215 remarkably inhibited the tumor growth of hepatoma cells in nude mice. Collectively, relative to wild type HBx, HBxΔ127 strongly enhances proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT. Our finding provides new insights into the mechanism of HBx mutant HBxΔ127 in promotion of proliferation of hepatoma cells.

  7. Survey of nine surface mines in North America. [Nine different mines in USA and Canada

    SciTech Connect

    Hayes, L.G.; Brackett, R.D.; Floyd, F.D.

    1981-01-01

    This report presents the information gathered by three mining engineers in a 1980 survey of nine surface mines in the United States and Canada. The mines visited included seven coal mines, one copper mine, and one tar sands mine selected as representative of present state of the art in open pit, strip, and terrace pit mining. The purpose of the survey was to investigate mining methods, equipment requirements, operating costs, reclamation procedures and costs, and other aspects of current surface mining practices in order to acquire basic data for a study comparing conventional and terrace pit mining methods, particularly in deeper overburdens. The survey was conducted as part of a project under DOE Contract No. DE-AC01-79ET10023 titled The Development of Optimal Terrace Pit Coal Mining Systems.

  8. Quantitative analysis of the taxation of uranium mines in Australia and Canada

    SciTech Connect

    Barnett, D.W.; Anderson, D.L.

    1984-01-01

    The degree of neutrality of a tax policy is a gauge of how willing a government is to share in the risk of mineral development. This paper analyzes the practical characteristics of the uranium taxation policies of the Northern Territory in Australia and Saskatchewan in Canada. It superimposes these two policies on a large Australian uranium mine, based on the Ranger mine, and on a slightly larger Canadian mine, based on the Key Lake mine. The analysis focuses on the impact on the net-present-value of the producers' returns, the sharing of economic rent between the arms of government and the producer, and on the apparent neutrality of the tax policies. 24 references, 6 figures.

  9. From Pushing Paper to Pushing Dirt - Canada's Largest LLRW Cleanup Gets Underway - 13111

    SciTech Connect

    Veen, Walter van; Lawrence, Dave

    2013-07-01

    The Port Hope Project is the larger of the two projects in the Port Hope Area Initiative (PHAI), Canada's largest low level radioactive waste (LLRW) cleanup. With a budget of approximately $1 billion, the Port Hope Project includes a broad and complex range of remedial elements from a state of the art water treatment plant, an engineered waste management facility, municipal solid waste removal, remediation of 18 major sites within the Municipality of Port Hope (MPH), sediment dredging and dewatering, an investigation of 4,800 properties (many of these homes) to identify LLRW and remediation of approximately 450 of these properties. This paper discusses the status of the Port Hope Project in terms of designs completed and regulatory approvals received, and sets out the scope and schedule for the remaining studies, engineering designs and remediation contracts. (authors)

  10. Analysis of Biomass Feedstock Availability and Variability for the Peace River Region of Alberta, Canada

    SciTech Connect

    Stephen, Jamie; Sokhansanj, Shahabaddine; Bi, X.T.; Sowlati, T.; Kloeck, T.; Townley-Smith, Lawrence; Stumborg, Mark

    2009-11-01

    Biorefineries or other biomass-dependent facilities require a predictable, dependable feedstock supplied over many years to justify capital investments. Determining inter-year variability in biomass availability is essential to quantifying the feedstock supply risk. Using a geographic information system (GIS) and historic crop yield data, average production was estimated for 10 sites in the Peace River region of Alberta, Canada. Four high-yielding potential sites were investigated for variability over a 20 year time-frame (1980 2000). The range of availability was large, from double the average in maximum years to nothing in minimum years. Biomass availability is a function of grain yield, the biomass to grain ratio, the cropping frequency, and residue retention rate to ensure future crop productivity. Storage strategies must be implemented and alternate feedstock sources identified to supply biomass processing facilities in low-yield years.

  11. Gas reservoir potential of the Lower Ordovician Beekmantown Group, Quebec Lowlands, Canada discussion

    SciTech Connect

    Friedman, G.M.

    1996-10-01

    Dykstra and Longman (1995), in an interesting paper, discussed the gas-reservoir potential of the Lower Ordovician Beekmantown Group of Quebec, Canada. They pointed out that the dolomites of this group provide an important exploration target in both the autochthon and the overlying thrust sheets. They then compare their rocks with those of correlative units in Oklahoma. Nowhere in their paper do they relate their study to the extensive work on these same rocks in the contiguous parts of the same basin in neighboring New York state. The purpose of this discussion is to fill in this lack and provide information on prospective Cambrian-Ordovician reservoirs in New York state, for which the Oil and Gas Investor (Anonymous, 1995a) has predicted counties of western New York are the next frontier for the Cambrian-Ordovician play. Dykstra and Longman (1995) compare their Quebec rocks with those of correlative rocks in faraway Oklahoma and completely overlook those in the same basin in nearby New York. At least one of the boreholes that we have studied in the St. Lawrence Valley is only tens of miles from their boreholes (Harris and Friedman, 1982). During the past 31 yr our team alone has published at least 50 papers and abstracts on the surface and subsurface geology of the Beekmantown Group in New York state. Dykstra and Longman`s (1995) paper provides data identical to those we have obtained for the contiguous New York Beekmantown (for a partial reference list see Friedman, 1993, 1994a, b, 1995). Because no reference to New York state is included in their reference section, I want to quote from an abstract titled {open_quotes}Gas Potential of the Eastern Overthrust...New York{close_quotes}(Friedman, s1992), which compares with their title {open_quotes}Gas Reservoir Potential...of Quebec, Canada{close_quotes} (Dykstra and Longman, 1995).

  12. Grain Handling and Transportation Policy in Canada: Implications for the United States

    DOE PAGES [OSTI]

    Nolan, James; Peterson, Steven K

    2015-08-01

    The grain handling and transportation system in Canada (GHTS) is currently going through a major transition, both with respect to handling and transportation. Historically, the system has pitted farmers against the railways with respect to securing individual fair shares of grain revenues. But with the removal of the single desk marketing and logistics function of the Canadian Wheat Board (CWB) in late 2012, a very interesting and potentially game-changing outcome is emerging with respect to the new functionality of the grain companies in the Canadian system. While historical awareness of rail s natural monopoly position in the grain handling systemmore » has kept that sector regulated (in several ways) for close to a century, we are now starting to see the effects of a less than competitive Canadian grain handling sector on revenue sharing, along with renewed movement in the industry with respect to buyouts and potential mergers. This overview will highlight some of the changes now occurring and how they are potentially going to interact or evolve as the system moves forward. For example, the on-going regulatory instrument used to regulate grain transportation rates in Canada (called the maximum revenue entitlement (MRE) or revenue cap) is under current debate because of the introduction a few months ago of a modification to an old regulatory instrument known as extended (or reciprocal) interswitching. As opposed to the revenue cap which is a direct intervention on monopoly behavior, extended interswitching is designed to encourage the major Canadian grain carriers to compete with one another and potentially seek out new traffic (Nolan and Skotheim, 2008). But the most intriguing aspect of extended interswitching is how it might allow a major rail carrier from the U.S. to solicit grain traffic in some areas of the Canadian grain transportation system.« less

  13. Grain Handling and Transportation Policy in Canada: Implications for the United States

    SciTech Connect

    Nolan, James; Peterson, Steven K

    2015-01-01

    The grain handling and transportation system in Canada (GHTS) is currently going through a major transition, both with respect to handling and transportation. Historically, the system has pitted farmers against the railways with respect to securing individual fair shares of grain revenues. But with the removal of the single desk marketing and logistics function of the Canadian Wheat Board (CWB) in late 2012, a very interesting and potentially game-changing outcome is emerging with respect to the new functionality of the grain companies in the Canadian system. While historical awareness of rail s natural monopoly position in the grain handling system has kept that sector regulated (in several ways) for close to a century, we are now starting to see the effects of a less than competitive Canadian grain handling sector on revenue sharing, along with renewed movement in the industry with respect to buyouts and potential mergers. This overview will highlight some of the changes now occurring and how they are potentially going to interact or evolve as the system moves forward. For example, the on-going regulatory instrument used to regulate grain transportation rates in Canada (called the maximum revenue entitlement (MRE) or revenue cap) is under current debate because of the introduction a few months ago of a modification to an old regulatory instrument known as extended (or reciprocal) interswitching. As opposed to the revenue cap which is a direct intervention on monopoly behavior, extended interswitching is designed to encourage the major Canadian grain carriers to compete with one another and potentially seek out new traffic (Nolan and Skotheim, 2008). But the most intriguing aspect of extended interswitching is how it might allow a major rail carrier from the U.S. to solicit grain traffic in some areas of the Canadian grain transportation system.

  14. Grain Handling and Transportation Policy in Canada: Implications for the United States

    SciTech Connect

    Nolan, James; Peterson, Steven K

    2015-08-01

    The grain handling and transportation system in Canada (GHTS) is currently going through a major transition, both with respect to handling and transportation. Historically, the system has pitted farmers against the railways with respect to securing individual fair shares of grain revenues. But with the removal of the single desk marketing and logistics function of the Canadian Wheat Board (CWB) in late 2012, a very interesting and potentially game-changing outcome is emerging with respect to the new functionality of the grain companies in the Canadian system. While historical awareness of rail s natural monopoly position in the grain handling system has kept that sector regulated (in several ways) for close to a century, we are now starting to see the effects of a less than competitive Canadian grain handling sector on revenue sharing, along with renewed movement in the industry with respect to buyouts and potential mergers. This overview will highlight some of the changes now occurring and how they are potentially going to interact or evolve as the system moves forward. For example, the on-going regulatory instrument used to regulate grain transportation rates in Canada (called the maximum revenue entitlement (MRE) or revenue cap) is under current debate because of the introduction a few months ago of a modification to an old regulatory instrument known as extended (or reciprocal) interswitching. As opposed to the revenue cap which is a direct intervention on monopoly behavior, extended interswitching is designed to encourage the major Canadian grain carriers to compete with one another and potentially seek out new traffic (Nolan and Skotheim, 2008). But the most intriguing aspect of extended interswitching is how it might allow a major rail carrier from the U.S. to solicit grain traffic in some areas of the Canadian grain transportation system.

  15. Mitsubishi iMiEV: An Electric Mini-Car in NREL's Advanced Technology Vehicle Fleet (Fact Sheet)

    SciTech Connect

    Not Available

    2011-10-01

    This fact sheet highlights the Mitsubishi iMiEV, an electric mini-car in the advanced technology vehicle fleet at the National Renewable Energy Laboratory (NREL). In support of the U.S. Department of Energy's fast-charging research efforts, NREL engineers are conducting charge and discharge performance testing on the vehicle. NREL's advanced technology vehicle fleet features promising technologies to increase efficiency and reduce emissions without sacrificing safety or comfort. The fleet serves as a technology showcase, helping visitors learn about innovative vehicles that are available today or are in development. Vehicles in the fleet are representative of current, advanced, prototype, and emerging technologies.

  16. Summer outdoor temperature and occupational heat-related illnesses in Quebec (Canada)

    SciTech Connect

    Adam-Poupart, Ariane; Smargiassi, Audrey; Busque, Marc-Antoine; Duguay, Patrice; Fournier, Michel; Zayed, Joseph; Labrèche, France

    2014-10-15

    Background: Predicted rise in global mean temperature and intensification of heat waves associated with climate change present an increasing challenge for occupational health and safety. Although important scientific knowledge has been gathered on the health effects of heat, very few studies have focused on quantifying the association between outdoor heat and mortality or morbidity among workers. Objective: To quantify the association between occupational heat-related illnesses and exposure to summer outdoor temperatures. Methods: We modeled 259 heat-related illnesses compensated by the Workers' Compensation Board of Quebec between May and September, from 1998 to 2010, with maximum daily summer outdoor temperatures in 16 health regions of Quebec (Canada) using generalized linear models with negative binomial distributions, and estimated the pooled effect sizes for all regions combined, by sex and age groups, and for different time lags with random-effect models for meta-analyses. Results: The mean daily compensation count was 0.13 for all regions of Quebec combined. The relationship between daily counts of compensations and maximum daily temperatures was log-linear; the pooled incidence rate ratio (IRR) of daily heat-related compensations per 1 °C increase in daily maximum temperatures was 1.419 (95% CI 1.326 to 1.520). Associations were similar for men and women and by age groups. Increases in daily maximum temperatures at lags 1 and 2 and for two and three-day lag averages were also associated with increases in daily counts of compensations (IRRs of 1.206 to 1.471 for every 1 °C increase in temperature). Conclusion: This study is the first to quantify the association between occupational heat-related illnesses and exposure to summer temperatures in Canada. The model (risk function) developed in this study could be useful to improve the assessment of future impacts of predicted summer outdoor temperatures on workers and vulnerable groups, particularly in colder

  17. Fact #832: August 4, 2014 Over Half of the Refueling Stations in the U.S. and Canada Sell Diesel Fuel

    Energy.gov [DOE]

    A 2014 survey of over 110,000 refueling stations in the U.S. and Canada shows that over half of all refueling stations sell diesel fuel. The survey results are shown for five different regions of...

  18. U.S. Partners with Canada to Renew Funding for World's Largest International CO2 Storage Project in Depleted Oil Fields

    Office of Energy Efficiency and Renewable Energy (EERE)

    The U.S. Department of Energy and Natural Resources Canada announced today a total of $5.2 million has been committed by the two governments to bring a benchmark carbon dioxide injection project to successful conclusion in 2011.

  19. Guide to Federal Regulation of Sales of Imported Electricity in Canada, Mexico and the United States - English Version

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    GUIDE TO FEDERAL REGULATION OF SALES OF IMPORTED ELECTRICITY IN CANADA, MEXICO, AND THE UNITED STATES A Publication of The North American Energy Working Group January 2005 1 The North American Energy Working Group The North American Energy Working Group (NAEWG) was established in spring of 2001 by the Canadian Minister of Natural Resources, the Mexican Secretary of Energy and the U.S. Secretary of Energy, to enhance North American energy cooperation. The NAEWG is led by officials from Natural

  20. Regulatory Oversight of the Legacy Gunner Uranium Mine and Mill Site in Northern Saskatchewan, Canada - 13434

    SciTech Connect

    Stenson, Ron; Howard, Don

    2013-07-01

    As Canada's nuclear regulator, the Canadian Nuclear Safety Commission (CNSC) is responsible for licensing all aspects of uranium mining, including remediation activities at legacy sites. Since these sites already existed when the current legislation came into force in 2000, and the previous legislation did not apply, they present a special case. The Nuclear Safety and Control Act (NSCA), was written with cradle-to- grave oversight in mind. Applying the NSCA at the end of a 'facilities' life-cycle poses some challenges to both the regulator and the proponent. When the proponent is the public sector, even more challenges can present themselves. Although the licensing process for legacy sites is no different than for any other CNSC license, assuring regulatory compliance can be more complicated. To demonstrate how the CNSC has approached the oversight of legacy sites the history of the Commission's involvement with the Gunnar uranium mine and mill site provides a good case study. The lessons learned from the CNSC's experience regulating the Gunnar site will benefit those in the future who will need to regulate legacy sites under existing or new legislation. (authors)