National Library of Energy BETA

Sample records for mi street address

  1. Address:

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Additive Manufacturing: Pursuing the Promise Additive Manufacturing: Pursuing the Promise Fact sheet overviewing additive manufacturing techniques that are projected to exert a profound impact on manufacturing. Additive Manufacturing: Pursuing the Promise (1.42 MB) More Documents & Publications Unlocking the Potential of Additive Manufacturing in the Fuel Cells Industry CEMI Accomplishments Report Fiber Reinforced Polymer Composite Manufacturing Workshop

    Address: ~~. . ~L~ -'7(J'",

  2. Frequently Asked Questions About the Municipal Solid-State Street Lighting Consortium

    Energy.gov [DOE]

    This page addresses many of the questions about the Municipal Solid-State Street Lighting Consortium.

  3. DOE - Office of Legacy Management -- Adrian - MI 01

    Office of Legacy Management (LM)

    Adrian - MI 01 FUSRAP Considered Sites Adrian, MI Alternate Name(s): Bridgeport Brass Co. Special Metals Extrusion Plant Bridgeport Brass Company General Motors General Motors Company, Adrian MI.01-1 Location: 1450 East Beecher Street, Adrian, Michigan MI.01-3 Historical Operations: Performed uranium extrusion research and development and metal fabrication work for the AEC using uranium, thorium, and plutonium. MI.01-2 Eligibility Determination: Eligible MI.01-1 Radiological Survey(s):

  4. Report from the Street

    Energy Saver

    SHERMAN STREET, CAMBRIDGE, MA 02140 617.354.4502 LAMPARTNERS.COM BLOG.LAMPARTNERS.COM Report from the Street Glenn Heinmiller, FIALD, LC, LEED AP Principal, Lam Partners Chair,...

  5. LED Street Lighting

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    21, 2016 LED Street Lighting The American Medical Association's (AMA) recently adopted community guidance on street lighting adds another influential voice to issues that have been discussed in the lighting community for some time now, regarding light at night, its potential impacts on human health and the environment, and how best to minimize those impacts. While the AMA's guidance is intended to reduce the harmful human and environmental effects of street lighting in general, it focuses on

  6. 200 N. Spring Street

    Office of Legacy Management (LM)

    Riordon .', 200 N. Spring Street 'Los Angeles, California ,90012 ' Dear Mayor Riordon: " ... 'i' ,, : ,, ' . cci H., Coll.ins,'State.of California. ."' ' I. , ,I .. , '.

  7. Demonstration of LED Street Lighting

    SciTech Connect

    Kinzey, B. R.; Royer, M. P.; Hadjian, M.; Kauffman, R.

    2013-06-01

    GATEWAY program and Municipal Solid-State Street Lighting Consortium report on a demonstration of LED street lighting in Kansas City, MO.

  8. DOE Street Lighting Consortium Releases Results of Public Street...

    Energy Saver

    DOE's Municipal Solid-State Street Lighting Consortium (MSSLC) has released the results of a voluntary web-based inventory survey of public street and area lighting across the ...

  9. 701 Ninth Street, NW

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    01 Ninth Street, NW Washington, DC 20068 202 872-3057 William M. Gausman Vice President, Asset Management January 8, 2007 Mr. Anthony J. Como SEA Document Manager U.S. Department of Energy 1000 Independence Avenue, SW Washington, DC 20585 Re: Special Environmental Analysis For Actions Taken Under U.S. Department of Energy Emergency Orders Regarding Operation of the Potomac River Generating Station in Alexandria, Virginia Dear Mr. Como: Potomac Electric Power Company ("Pepco") has

  10. Keynote Address

    Energy.gov [DOE]

    Wednesday's keynote address by Dr. David Danielson, Assistant Secretary for Energy Efficiency and Renewable Energy, U.S. Department of Energy.

  11. GATEWAY Demonstrations: LED Street Lighting

    SciTech Connect

    Cook, Tyson; Shackelford, Jordan; Pang, Terrance Pang

    2008-12-01

    This report summarizes an assessment project conducted to study the performance of light emitting diode (LED) luminaires in a street lighting application in San Francisco, CA.

  12. Street sweeping and stormwater regulations

    SciTech Connect

    Not Available

    1993-10-01

    This article examines the role of street sweeping in meeting the requirements of the Clean Water Act stormwater regulations. The article identifies those industrial and municipal activities which are covered by the regulations and cites frequent sweeping of site surfaces for industry and street sweeping for municipalities as an integral part of compliance plans.

  13. Detroit Street Lighting Report | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Detroit Street Lighting Report Detroit Street Lighting Report 2015_restoring-detroit.pdf (929.98 KB) More Documents & Publications LED Roadway Lighting OCTOBER 2015 POSTINGS Demonstration Assessment of Light Emitting Diode (LED) Street Lighting, Final Report

  14. Cate Street Capital Inc | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Cate Street Capital Inc Jump to: navigation, search Name: Cate Street Capital, Inc. Place: Portsmouth, New Hampshire Zip: 3801 Sector: Renewable Energy Product: New Hampshire-based...

  15. Pecan Street Project Inc | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Project Inc Jump to: navigation, search Name: Pecan Street Project Inc Place: Austin, Texas Zip: 78759 Product: Austin-based smart grid, energy system developer. The Pecan Street...

  16. Measurement of the direct <mi>CP> -violating parameter <mi>Ami><mi>CP> in the decay <mi>D>+<mi>Kmi>-<mimi>+<mi>π>+

    SciTech Connect

    Abazov, V. M.; Abbott, B.; Acharya, B. S.; Adams, M.; Adams, T.; Agnew, J. P.; Alexeev, G. D.; Alkhazov, G.; Alton, A.; Askew, A.; Atkins, S.; Augsten, K.; Avila, C.; Badaud, F.; Bagby, L.; Baldin, B.; Bandurin, D. V.; Banerjee, S.; Barberis, E.; Baringer, P.; Bartlett, J. F.; Bassler, U.; Bazterra, V.; Bean, A.; Begalli, M.; Bellantoni, L.; Beri, S. B.; Bernardi, G.; Bernhard, R.; Bertram, I.; Besançon, M.; Beuselinck, R.; Bhat, P. C.; Bhatia, S.; Bhatnagar, V.; Blazey, G.; Blessing, S.; Bloom, K.; Boehnlein, A.; Boline, D.; Boos, E. E.; Borissov, G.; Borysova, M.; Brandt, A.; Brandt, O.; Brock, R.; Bross, A.; Brown, D.; Bu, X. B.; Buehler, M.; Buescher, V.; Bunichev, V.; Burdin, S.; Buszello, C. P.; Camacho-Pérez, E.; Casey, B. C. K.; Castilla-Valdez, H.; Caughron, S.; Chakrabarti, S.; Chan, K. M.; Chandra, A.; Chapon, E.; Chen, G.; Cho, S. W.; Choi, S.; Choudhary, B.; Cihangir, S.; Claes, D.; Clutter, J.; Cooke, M.; Cooper, W. E.; Corcoran, M.; Couderc, F.; Cousinou, M. -C.; Cutts, D.; Das, A.; Davies, G.; de Jong, S. J.; De La Cruz-Burelo, E.; Déliot, F.; Demina, R.; Denisov, D.; Denisov, S. P.; Desai, S.; Deterre, C.; DeVaughan, K.; Diehl, H. T.; Diesburg, M.; Ding, P. F.; Dominguez, A.; Dubey, A.; Dudko, L. V.; Duperrin, A.; Dutt, S.; Eads, M.; Edmunds, D.; Ellison, J.; Elvira, V. D.; Enari, Y.; Evans, H.; Evdokimov, V. N.; Fauré, A.; Feng, L.; Ferbel, T.; Fiedler, F.; Filthaut, F.; Fisher, W.; Fisk, H. E.; Fortner, M.; Fox, H.; Fuess, S.; Garbincius, P. H.; Garcia-Bellido, A.; García-González, J. A.; Gavrilov, V.; Geng, W.; Gerber, C. E.; Gershtein, Y.; Ginther, G.; Gogota, O.; Golovanov, G.; Grannis, P. D.; Greder, S.; Greenlee, H.; Grenier, G.; Gris, Ph.; Grivaz, J. -F.; Grohsjean, A.; Grünendahl, S.; Grünewald, M. W.; Guillemin, T.; Gutierrez, G.; Gutierrez, P.; Haley, J.; Han, L.; Harder, K.; Harel, A.; Hauptman, J. M.; Hays, J.; Head, T.; Hebbeker, T.; Hedin, D.; Hegab, H.; Heinson, A. P.; Heintz, U.; Hensel, C.; Heredia-De La Cruz, I.; Herner, K.; Hesketh, G.; Hildreth, M. D.; Hirosky, R.; Hoang, T.; Hobbs, J. D.; Hoeneisen, B.; Hogan, J.; Hohlfeld, M.; Holzbauer, J. L.; Howley, I.; Hubacek, Z.; Hynek, V.; Iashvili, I.; Ilchenko, Y.; Illingworth, R.; Ito, A. S.; Jabeen, S.; Jaffré, M.; Jayasinghe, A.; Jeong, M. S.; Jesik, R.; Jiang, P.; Johns, K.; Johnson, E.; Johnson, M.; Jonckheere, A.; Jonsson, P.; Joshi, J.; Jung, A. W.; Juste, A.; Kajfasz, E.; Karmanov, D.; Katsanos, I.; Kaur, M.; Kehoe, R.; Kermiche, S.; Khalatyan, N.; Khanov, A.; Kharchilava, A.; Kharzheev, Y. N.; Kiselevich, I.; Kohli, J. M.; Kozelov, A. V.; Kraus, J.; Kumar, A.; Kupco, A.; Kurča, T.; Kuzmin, V. A.; Lammers, S.; Lebrun, P.; Lee, H. S.; Lee, S. W.; Lee, W. M.; Lei, X.; Lellouch, J.; Li, D.; Li, H.; Li, L.; Li, Q. Z.; Lim, J. K.; Lincoln, D.; Linnemann, J.; Lipaev, V. V.; Lipton, R.; Liu, H.; Liu, Y.; Lobodenko, A.; Lokajicek, M.; Lopes de Sa, R.; Luna-Garcia, R.; Lyon, A. L.; Maciel, A. K. A.; Madar, R.; Magaña-Villalba, R.; Malik, S.; Malyshev, V. L.; Mansour, J.; Martínez-Ortega, J.; McCarthy, R.; McGivern, C. L.; Meijer, M. M.; Melnitchouk, A.; Menezes, D.; Mercadante, P. G.; Merkin, M.; Meyer, A.; Meyer, J.; Miconi, F.; Mondal, N. K.; Mulhearn, M.; Nagy, E.; Narain, M.; Nayyar, R.; Neal, H. A.; Negret, J. P.; Neustroev, P.; Nguyen, H. T.; Nunnemann, T.; Orduna, J.; Osman, N.; Osta, J.; Pal, A.; Parashar, N.; Parihar, V.; Park, S. K.; Partridge, R.; Parua, N.; Patwa, A.; Penning, B.; Perfilov, M.; Peters, Y.; Petridis, K.; Petrillo, G.; Pétroff, P.; Pleier, M. -A.; Podstavkov, V. M.; Popov, A. V.; Prewitt, M.; Price, D.; Prokopenko, N.; Qian, J.; Quadt, A.; Quinn, B.; Ratoff, P. N.; Razumov, I.; Ripp-Baudot, I.; Rizatdinova, F.; Rominsky, M.; Ross, A.; Royon, C.; Rubinov, P.; Ruchti, R.; Sajot, G.; Sánchez-Hernández, A.; Sanders, M. P.; Santos, A. S.; Savage, G.; Savitskyi, M.; Sawyer, L.; Scanlon, T.; Schamberger, R. D.; Scheglov, Y.; Schellman, H.; Schwanenberger, C.; Schwienhorst, R.; Sekaric, J.; Severini, H.; Shabalina, E.; Shary, V.; Shaw, S.; Shchukin, A. A.; Simak, V.; Skubic, P.; Slattery, P.; Smirnov, D.; Snow, G. R.; Snow, J.; Snyder, S.; Söldner-Rembold, S.; Sonnenschein, L.; Soustruznik, K.; Stark, J.; Stoyanova, D. A.; Strauss, M.; Suter, L.; Svoisky, P.; Titov, M.; Tokmenin, V. V.; Tsai, Y. -T.; Tsybychev, D.; Tuchming, B.; Tully, C.; Uvarov, L.; Uvarov, S.; Uzunyan, S.; Van Kooten, R.; van Leeuwen, W. M.; Varelas, N.; Varnes, E. W.; Vasilyev, I. A.; Verkheev, A. Y.; Vertogradov, L. S.; Verzocchi, M.; Vesterinen, M.; Vilanova, D.; Vokac, P.; Wahl, H. D.; Wang, M. H. L. S.; Warchol, J.; Watts, G.; Wayne, M.; Weichert, J.; Welty-Rieger, L.; Williams, M. R. J.; Wilson, G. W.; Wobisch, M.; Wood, D. R.; Wyatt, T. R.; Xie, Y.; Yamada, R.; Yang, S.; Yasuda, T.; Yatsunenko, Y. A.; Ye, W.; Ye, Z.; Yin, H.; Yip, K.; Youn, S. W.; Yu, J. M.; Zennamo, J.; Zhao, T. G.; Zhou, B.; Zhu, J.; Zielinski, M.; Zieminska, D.; Zivkovic, L.

    2014-12-01

    We measure the direct mi>Cmi>mi>P>-violating parameter mi>Ami>mi>Cmi>mi>Pmi> for the decay of the charged charm meson, mi>Dmi>+mi>Kmi>-mi>πmi>+mi>πmi>+ (and charge conjugate), using the full 10.4 mi>fbmi>-1 sample of mi>p>mi>p>¯ collisions at mi>smi>=1.96 mi>TeVmi> collected by the D0 detector at the Fermilab Tevatron collider. We extract the raw reconstructed charge asymmetry by fitting the invariant mass distributions for the sum and difference of charge-specific samples. This quantity is then corrected for detector-related asymmetries using data-driven methods and for possible physics asymmetries (from mi>B>mi>D

  17. LEDs for Street Lighting—Here Today

    SciTech Connect

    2013-11-29

    Fact sheet that provides a brief overview of the viability of LED street lighting in municipalities and highlights case studies of two cities—Los Angeles and Seattle—that have invested in LED street lighting.

  18. Manhattan Project: Los Alamos Street Scene

    Office of Scientific and Technical Information (OSTI)

    LOS ALAMOS STREET SCENE Los Alamos (The Town) Resources > Photo Gallery Los Alamos street scene. Fuller Lodge and the "Big House" are visible in the distance (see below). Above is ...

  19. SSL Demonstration: Street Lighting, Kansas City, MO

    SciTech Connect

    2013-08-01

    GATEWAY program report brief summarizing an SSL street lighting demonstration at nine separate installations in Kansas City, MO.

  20. 2015 Wall Street Perspectives on SMRs Update | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    5 Wall Street Perspectives on SMRs Update 2015 Wall Street Perspectives on SMRs Update Summary briefing on the results of a September 2015 survey of Wall Street attitudes toward SMRs. 2015 Financial Survey: Nuclear Energy (415.36 KB) More Documents & Publications 2014 Wall Street Perspective on SMRs 2014 Wall Street Perspectives on SMRs - Report 2013 Wall Street Perspective on SMRs

  1. 2014 Wall Street Perspectives on SMRs - Report | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    4 Wall Street Perspectives on SMRs - Report 2014 Wall Street Perspectives on SMRs - Report Summary of the results of a 2014 survey of Wall Street attitudes toward small modular reactors. View from Wall Street: Nuclear Energy and Small Modular Reactors (284.42 KB) More Documents & Publications 2013 Wall Street Perspective on SMRs 2014 Wall Street Perspective on SMRs 2015 Wall Street Perspectives on SMRs Update

  2. Restoring Detroit's Street Lighting System

    SciTech Connect

    Kinzey, Bruce R.

    2015-10-21

    The City of Detroit is undertaking a comprehensive restoration of its street lighting system that includes transitioning the existing high-pressure sodium (HPS) sources to light-emitting diode (LED). Detroit’s well-publicized financial troubles over the last several years have added many hurdles and constraints to this process. Strategies to overcome these issues have largely been successful, but have also brought some mixed results. This document provides an objective review of the circumstances surrounding the system restoration, the processes undertaken and decisions made, and the results so far.

  3. DOE Street Lighting Consortium Releases Results of Public Street and Area Lighting Inventory Survey

    Office of Energy Efficiency and Renewable Energy (EERE)

    DOE's Municipal Solid-State Street Lighting Consortium (MSSLC) has released the results of a voluntary web-based inventory survey of public street and area lighting across the U.S., conducted...

  4. Municipal Consortium LED Street Lighting Workshop Presentations...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    City of Los Angeles Bureau of Street Lighting San Jose's "Smart" LED Streetlights: Controlled Amy Olay, City of San Jose Adaptive Lighting Controls Panel David Bueno, ...

  5. California Street Biomass Facility | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    2006 Database Retrieved from "http:en.openei.orgwindex.php?titleCaliforniaStreetBiomassFacility&oldid397263" Feedback Contact needs updating Image needs updating...

  6. LED Street Lighting Conversion Workshop Presentations

    Office of Energy Efficiency and Renewable Energy (EERE)

    This page provides links to the presentations given at the National League of Cities Mobile Workshop, LED Street Lighting Conversion: Saving Your Community Money, While Improving Public Safety,...

  7. America Saves! Energizing Main Street Small Businesses

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energizing Main Street Small Businesses 2014 Building Technologies Office Peer Review Mark Huppert mhuppert@savingplaces.org Ric Cochrane rcochrane@savingplaces.org National ...

  8. Flooded First Street at Y-12 Plant | Y-12 National Security Complex

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Flooded First Street at ... Flooded First Street at Y-12 Plant Vehicles negotiate flooded First Street at Y-12 Plant

  9. Financing Guidance for LED Street Lighting Programs

    Energy.gov [DOE]

    Financing an LED street lighting replacement program can present a hurdle for many system owners, even if the planned transition offers very favorable economics. Replacing the existing system requires a significant budget, particularly as the scope of the program increases. Cities such as Los Angeles and Seattle have invested many millions of dollars into their (very successful) LED street lighting replacement programs.

  10. DOE Tour of Zero Floorplans: Taylor Street by Greenhill Contracting |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Taylor Street by Greenhill Contracting DOE Tour of Zero Floorplans: Taylor Street by Greenhill Contracting DOE Tour of Zero Floorplans: Taylor Street by Greenhill Contracting

  11. 2013 Wall Street Perspective on SMRs | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Wall Street Perspective on SMRs 2013 Wall Street Perspective on SMRs Summary of results of a 2013 survey on Wall Street attitudes toward small modular reactors. PDF icon 2013 Wall ...

  12. Demonstration of LED Street Lighting in Kansas City, MO (Technical...

    Office of Scientific and Technical Information (OSTI)

    Technical Report: Demonstration of LED Street Lighting in Kansas City, MO Citation Details In-Document Search Title: Demonstration of LED Street Lighting in Kansas City, MO Nine ...

  13. DOE - Office of Legacy Management -- GSA 39th Street Warehouse...

    Office of Legacy Management (LM)

    GSA 39th Street Warehouse - IL 02 FUSRAP Considered Sites Site: GSA 39TH STREET WAREHOUSE (IL.02 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated ...

  14. Text-Alternative Version: Using the Street and Parking Facility...

    Energy Saver

    Using the Street and Parking Facility Lighting Retrofit Financial Analysis Tool Text-Alternative Version: Using the Street and Parking Facility Lighting Retrofit Financial Analysis ...

  15. Solar Resource Measurements in 1400 JR Lynch Street, Jackson...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Solar Resource Measurements in 1400 JR Lynch Street, Jackson, Mississippi Cooperative ... CRADA Number: CRD-07-254 CRADA Title: Solar Resource Measurements in 1400 JR Lynch Street, ...

  16. 2014 Wall Street Perspectives on SMRs - Report | Department of...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Perspectives on SMRs - Report 2014 Wall Street Perspectives on SMRs - Report Summary of the results of a 2014 survey of Wall Street attitudes toward small modular reactors. PDF ...

  17. Demonstration Assessment of Light Emitting Diode (LED) Street...

    Energy.gov [DOE] (indexed site)

    This report summarizes an LED street lighting assessment project conducted to study the applicability of LED luminaires in a street lighting application. emergingtechreportleds...

  18. Remaining Barriers to LED Street Lighting

    Energy Saver

    ownership, involving multiple decision-makers * Utilities own 60-70% of street lighting inventory in U.S. * Sometimes more than one utility present in a given metro area * Often...

  19. One West Third Street Tulsa, Oklahoma

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Third Street Tulsa, Oklahoma 74103-3502 918-595-6600 Fax 918-595-6656 www.swpa.gov The ... Director, Division of Information Technology (CIO) Tulsa, Oklahoma Special thanks to: Ron ...

  20. Brighter Lights, Safer Streets | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Brighter Lights, Safer Streets Brighter Lights, Safer Streets May 15, 2012 - 5:56pm Addthis Workers install the final LED streetlight for DC's EECBG-funded energy efficient lighting upgrade. | Energy Department photo, credit Chris Galm. Workers install the final LED streetlight for DC's EECBG-funded energy efficient lighting upgrade. | Energy Department photo, credit Chris Galm. Chris Galm Marketing & Communications Specialist, Office of Energy Efficiency & Renewable Energy What does

  1. US ENC MI Site Consumption

    Energy Information Administration (EIA) (indexed site)

    MI Site Consumption million Btu $0 $500 $1,000 $1,500 $2,000 $2,500 US ENC MI Expenditures dollars ALL ENERGY average per household (excl. transportation) 0 2,000 4,000 6,000 8,000 10,000 12,000 US ENC MI Site Consumption kilowatthours $0 $250 $500 $750 $1,000 $1,250 $1,500 US ENC MI Expenditures dollars ELECTRICITY ONLY average per household * Michigan households use 123 million Btu of energy per home, 38% more than the U.S. average. * High consumption, combined with low costs for heating fuels

  2. Report Period: EIA ID NUMBER: Instructions: (e.g., Street Address...

    Energy Information Administration (EIA) (indexed site)

    Year Mo If this is a resubmission, enter an "X" in the block: Ext: Fax No.: Comments: ... changed since the last report, enter an "X" in the block: http:www.eia.govsurvey...

  3. Alternative Fuels Data Center: Natural Gas Street Sweepers Improve...

    Alternative Fuels and Advanced Vehicles Data Center

    Natural Gas Street Sweepers Improve Air Quality in New York to someone by E-mail Share Alternative Fuels Data Center: Natural Gas Street Sweepers Improve Air Quality in New York on ...

  4. 2014 Wall Street Perspective on SMRs | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Perspective on SMRs 2014 Wall Street Perspective on SMRs Summary briefing on the results of a 2014 survey of Wall Street attitudes toward SMRs. PDF icon 2014 New Generation ...

  5. Pittsburgh LED Street Lighting Research Project Performance Criteria

    Energy.gov [DOE]

    A Pittsburgh LED Street Lighting Research Project document on Technical and Aesthetic Performance for Business District LED Lighting.

  6. Municipal Consortium LED Street Lighting Workshop Presentations and

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Materials-Boston, MA | Department of Energy Boston, MA Municipal Consortium LED Street Lighting Workshop Presentations and Materials-Boston, MA This page provides links to the presentations given at the DOE Municipal Solid-State Street Lighting Consortium Workshop held in Boston August 2-3, 2012. Workshop Agenda DOE Municipal Solid-State Street Lighting Consortium James Brodrick, U.S. Department of Energy Boston's LED Street Lighting Initiative Joanne Massaro, Glenn Cooper, Matthew Mayrl,

  7. Text-Alternative Version: Evaluating LED Street Lighting Solutions |

    Energy Saver

    Department of Energy Evaluating LED Street Lighting Solutions Text-Alternative Version: Evaluating LED Street Lighting Solutions Below is the text-alternative version of the Evaluating LED Street Lighting Solutions webcast, held July 20, 2010. Edward Smalley: Good morning, everyone. Welcome to the Market Introduction Workshop, and the pre-conference webcast, Evaluating LED Street Lighting Solutions. This morning we have three panelists with us. Todd Rosenbaum from the city of Portland, with

  8. Using the Street and Parking Facility Lighting Retrofit Financial Analysis

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Tool | Department of Energy Information Resources » Webcasts » Using the Street and Parking Facility Lighting Retrofit Financial Analysis Tool Using the Street and Parking Facility Lighting Retrofit Financial Analysis Tool This August 22, 2013 webinar provided a guided walk-through of the Street and Parking Facility Lighting Retrofit Financial Analysis Tool. Developed by a partnership of the DOE Municipal Solid-State Street Lighting Consortium, the Clinton Climate Initiative/C40, and the

  9. Webcast: Evaluating LED Street Lighting Solutions | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Evaluating LED Street Lighting Solutions Webcast: Evaluating LED Street Lighting Solutions In this July 20, 2010 webcast, Edward Smalley of Seattle City Light provided an update on DOE Municipal Solid-State Street Lighting Consortium activities. The webcast also presented perspectives from members who are involved with implementing LED street lighting evaluations, including Tod Rosinbum of the City of Portland, Oregon, John Walter of National Grid, and Amy Olay of the City of San Jose,

  10. Addressing Big Data

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Addressing Big Data Challenges in Simulation-based Science Prof. Manish Parashar Rutgers University Tuesday, Jan 28, 2014 - 4:15PM MBG AUDITORIUM Refreshments at 4:00PM The ...

  11. US ENC MI Site Consumption

    Annual Energy Outlook

    ... Yes Yes No No 0% 20% 40% 60% 80% 100% US MI No Car CAR IS PARKED WITHIN 20 FT OF ELECTRICAL OUTLET More highlights from RECS on housing characteristics and energy-related ...

  12. Carrier Corporation 7310 West Morris Street

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Carrier Corporation 7310 West Morris Street Indianapolis, IN. 46231 July 11, 2016 U.S. Department of Energy Office of General Counsel 1000 Independence Avenue SW. Room 6A245 Washington, DC, 20585 RE: Comments to Docket Number: 2016-10956 Regulatory Burden RFI United Technologies Climate, Controls, and Security and its Carrier business would like to submit the following comments to the proposed questions as well as additional commentary as requested and referenced in the RFI. As referenced in the

  13. Smart Street Lights | GE Global Research

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Smart Manufacturing Innovation Smart Manufacturing Innovation Addthis Find out how advanced technologies developed by our latest institute will make U.S. manufacturing more productive, energy efficient, and competitive. Learn more about advanced manufacturing

    LightGrid Provides Real-Time Feedback From Street Lights Click to email this to a friend (Opens in new window) Share on Facebook (Opens in new window) Click to share (Opens in new window) Click to share on LinkedIn (Opens in new window)

  14. Real-time sub-<mi>>ngstrom...

    Office of Scientific and Technical Information (OSTI)

    Real-time sub-<mi>>ngstrom imaging of reversible and irreversible conformations in rhodium catalysts and graphene Kisielowski, Christian; Wang,...

  15. EECBG Success Story: Brighter Lights, Safer Streets | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Brighter Lights, Safer Streets EECBG Success Story: Brighter Lights, Safer Streets May 15, 2012 - 5:56pm Addthis Workers install the final LED streetlight for DC's EECBG-funded energy efficient lighting upgrade. | Energy Department photo, credit Chris Galm. Workers install the final LED streetlight for DC's EECBG-funded energy efficient lighting upgrade. | Energy Department photo, credit Chris Galm. Thanks to support from an Energy Department Recovery Act grant, Washington, DC streets are

  16. Considering LEDs for Street and Area Lighting | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Information Resources » Videos » Considering LEDs for Street and Area Lighting Considering LEDs for Street and Area Lighting View Jim Brodrick's keynote video from the September 2009 IES Street and Area Lighting Conference in Philadelphia. View the text-alternative version. Solid-State Lighting Home About the Solid-State Lighting Program Research & Development Understanding SSL Information Resources Conferences & Meetings Presentations Publications Webcasts Videos Tools

  17. Municipal Consortium LED Street Lighting Workshop Presentations and

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Materials-Los Angeles, CA | Department of Energy Los Angeles, CA Municipal Consortium LED Street Lighting Workshop Presentations and Materials-Los Angeles, CA This page provides links to the presentations given at the DOE Municipal Solid-State Street Lighting Consortium Workshop held in Los Angeles April 19-20, 2012. Presentations and Materials Workshop Agenda City of Los Angeles: Changing Our Glow for Efficiency Ed Ebrahimian, City of Los Angeles Bureau of Street Lighting L.M. Seventynine:

  18. Municipal Solid-State Street Lighting Consortium Kickoff Webcast |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Webcasts » Municipal Solid-State Street Lighting Consortium Kickoff Webcast Municipal Solid-State Street Lighting Consortium Kickoff Webcast This May 6, 2010 webcast served as the first official meeting of the new DOE Municipal Solid-State Street Lighting Consortium. Ed Smalley of Seattle City Light and Bruce Kinzey of Pacific Northwest National Laboratory discussed the Consortium's mission and goals, and provided an overview of its first steps, and opportunities to

  19. Get the Facts: LED Street Lighting | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Get the Facts: LED Street Lighting Get the Facts: LED Street Lighting June 21, 2016 - 12:11pm Addthis The American Medical Association's (AMA) recently adopted community guidance on street lighting adds another influential voice to issues that have been discussed in the lighting community for some time now, regarding light at night, its potential impacts on human health and the environment, and how best to minimize those impacts. While the AMA's guidance is intended to reduce the harmful human

  20. Webcast: Municipal Solid-State Street Lighting Consortium Retrofit

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Financial Analysis Tool | Department of Energy Municipal Solid-State Street Lighting Consortium Retrofit Financial Analysis Tool Webcast: Municipal Solid-State Street Lighting Consortium Retrofit Financial Analysis Tool This April 3, 2012 webcast presented information about the Retrofit Financial Analysis Tool developed by DOE"s Municipal Solid-State Street Lighting Consortium. Doug Elliott of Pacific Northwest National Laboratory provided a guided walk-through of what the tool can do

  1. Mi GmbH | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Mi GmbH Jump to: navigation, search Name: Mi GmbH Place: Switzerland Zip: CH-6340 Sector: Solar Product: Baar-based manufacturer and distributor of fruit juices. The firm is also...

  2. Frequently Asked Questions About the Municipal Solid-State Street...

    Office of Environmental Management (EM)

    on the needs of participants making investments in SSL street and area lighting products. ... DOE is congressionally mandated by the Energy Policy Act of 2005 to accelerate SSL ...

  3. Demonstration of LED Street Lighting in Kansas City, MO Kinzey...

    Office of Scientific and Technical Information (OSTI)

    Street Lighting in Kansas City, MO Kinzey, Bruce R.; Royer, Michael P.; Hadjian, M.; Kauffman, Rick LED streetlighting; field illuminance measurement LED streetlighting; field...

  4. SEAD Street Lighting Evaluation Tool | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Name: SEAD Street Lighting Evaluation Tool AgencyCompany Organization: SEAD Sector: Energy Focus Area: Energy Efficiency Resource Type: Softwaremodeling tools User Interface:...

  5. Street Legal Named SBA HUBZone Business of the Year

    Energy.gov [DOE]

    On Sept. 25, Street Legal Industries, Inc. was recognized as the U. S. Small Business Administration (SBA) 2014 Tennessee HUBZone Small Business of the Year.

  6. miRNAs in brain development

    SciTech Connect

    Petri, Rebecca; Malmevik, Josephine; Fasching, Liana; Åkerblom, Malin; Jakobsson, Johan

    2014-02-01

    MicroRNAs (miRNAs) are small, non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. In the brain, a large number of miRNAs are expressed and there is a growing body of evidence demonstrating that miRNAs are essential for brain development and neuronal function. Conditional knockout studies of the core components in the miRNA biogenesis pathway, such as Dicer and DGCR8, have demonstrated a crucial role for miRNAs during the development of the central nervous system. Furthermore, mice deleted for specific miRNAs and miRNA-clusters demonstrate diverse functional roles for different miRNAs during the development of different brain structures. miRNAs have been proposed to regulate cellular functions such as differentiation, proliferation and fate-determination of neural progenitors. In this review we summarise the findings from recent studies that highlight the importance of miRNAs in brain development with a focus on the mouse model. We also discuss the technical limitations of current miRNA studies that still limit our understanding of this family of non-coding RNAs and propose the use of novel and refined technologies that are needed in order to fully determine the impact of specific miRNAs in brain development. - Highlights: • miRNAs are essential for brain development and neuronal function. • KO of Dicer is embryonically lethal. • Conditional Dicer KO results in defective proliferation or increased apoptosis. • KO of individual miRNAs or miRNA families is necessary to determine function.

  7. CHP at Post Street in Downtown Seattle

    SciTech Connect

    Gent, Stan

    2012-04-12

    The Post Street project had four (4), 7.960 MW, Solar Taurus-70-10801S natural gas combustion turbines. Each turbine equipped with a 40,000 lb/hr heat recovery steam generator (HRSG). The dual-fuel HRSGs was capable of generating steam using gas turbine exhaust heat or surplus electric power. The generation capacity was nominally rated at 29.2 MW. The project as proposed had a fuel rate chargeable to power of 4,900 - 5,880 Btu/kWh dependent on time of year. The CHP plant, when operating at 29.2 MW, can recycle turbine exhaust into supply 145 kpph of steam to SSC per hour. The actual SSC steam loads will vary based on weather, building occupation, plus additions / reductions of customer load served. SSC produces up to 80 kpph of steam from a biomass boiler, which is currently base loaded all year.

  8. Brinkman Addresses JLab | Jefferson Lab

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Brinkman Addresses JLab Brinkman Addresses JLab Brinkman Addresses JLab Dr. William F. Brinkman, Director of the Department of Energy's Office of Science, addressed Jefferson Lab staff on the Office of Science perspective during his visit Monday. Dr. William F. Brinkman, Director of the Department of Energy's Office of Science, addressed Jefferson Lab staff on the Office of Science perspective during his visit Monday. "There is still a lot of interesting nuclear physics that we want to do

  9. Demonstration Assessment of Light Emitting Diode (LED) Street Lighting, Final Report

    Office of Energy Efficiency and Renewable Energy (EERE)

    This report summarizes an LED street lighting assessment project conducted to study the applicability of LED luminaires in a street lighting application.

  10. Municipal Consortium LED Street Lighting Workshop: April 19–20, Los Angeles, CA

    Energy.gov [DOE]

    Workshop Location: The Sheraton Los Angeles Downtown Hotel, 711 Hope Street, Los Angeles, CA 90017City Partner: City of Los Angeles Bureau of Street LightingCost: $175

  11. Keynote Address | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Keynote Address Keynote Address An overview and update on Environmental Management given by Alice Williams, Associate Principal Deputy Assistant Secretary of the Office of Environmental Management. Keynote Address (2.53 MB) More Documents & Publications EIS-0337-SA-01: Supplement Analysis West Valley Demonstration Project Low-Level Waste Shipment Chairs Meeting - October 2012

  12. The Recovery Act is "Lighting Up" the streets of Philadelphia

    Energy.gov [DOE]

    The Philadelphia Streets Department is converting 58,000 yellow and green traffic signals and will replace approximately 27,000 red LED lights that have come to the end of their useful life. The...

  13. The Honorable Sandra Freedman 306 E. Jackson Street

    Office of Legacy Management (LM)

    N()J (-j 3 ;;54 The Honorable Sandra Freedman 306 E. Jackson Street Tampa, Florida 33602 ... E&gill Fertilizer, Inc., Riverview, FL M. Jerrett, State of Florida @ Prmled with soy Ink ...

  14. Webcast: Municipal Solid-State Street Lighting Consortium Retrofit...

    Energy.gov [DOE] (indexed site)

    Laboratory provided a guided walk-through of what the tool can do and how to use it to evaluate costs and benefits associated with converting to LED street and roadway lighting. ...

  15. DOE Publishes Report on Detroit’s Street Lighting Conversion

    Office of Energy Efficiency and Renewable Energy (EERE)

    The U.S. Department of Energy has released a new report on the comprehensive street lighting restoration currently being undertaken by the City of Detroit, which includes transitioning the existing...

  16. DOE - Office of Legacy Management -- Try Street Terminal - PA...

    Office of Legacy Management (LM)

    Location: Try Street Terminal , Pittsburgh , Pennsylvania PA.14-1 Evaluation Year: 1987 PA.14-1 Site Operations: Circa 1943 - facility used to store 20 plus drums of uranium slag. ...

  17. FirstEnergy (Potomac Edison)- Municipal and Street Lighting Program

    Energy.gov [DOE]

    FirstEnergy (Potomac Edision) offers several incentives for non-residential and municipal customers to upgrade traffic signals, pedestrian signals, street lights to more efficient  fixtures. The...

  18. Secretary Moniz Applauds Detroit's LED Street Lighting Upgrades |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Applauds Detroit's LED Street Lighting Upgrades Secretary Moniz Applauds Detroit's LED Street Lighting Upgrades June 16, 2014 - 10:46am Addthis Secretary of Energy Ernest Moniz visited Detroit on May 22, 2014, to mark the city's progress installing energy-efficient LED streetlights in an update of its largely broken public lighting system, speaking at the Detroit Area Pre-College Engineering Program. Like so many cities across the country, Detroit is plagued with aging

  19. Municipal Consortium LED Street Lighting Workshop Presentations and

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Materials-Dallas, TX | Department of Energy Dallas, TX Municipal Consortium LED Street Lighting Workshop Presentations and Materials-Dallas, TX This page provides links to the presentations given at the DOE Municipal Solid-State Street Lighting Consortium Workshop held in Dallas March 15-16, 2012. Presentations and Materials Workshop Agenda ONCOR LED Streetlight Pilot & Technical Evaluation Update Michael Navarro, ONCOR Reading, Understanding, and Applying the LM-80 Standard Chad

  20. DOE - Office of Legacy Management -- Detrex Corp - MI 10

    Office of Legacy Management (LM)

    Detroit , Michigan MI.10-1 Evaluation Year: 1987 MI.10-2 Site Operations: Conducted experimental runs relative to picklingdegreasing of one handful of uranium turnings MI.10-1...

  1. Keynote Address | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    40PM to 2:05PM PDT Pacific Ballroom Wednesday keynote address by Dan Arvizu, Director, National Renewable Energy Laboratory

  2. DOE Municipal Solid-State Street Lighting Consortium | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    DOE Municipal Solid-State Street Lighting Consortium DOE Municipal Solid-State Street Lighting Consortium The DOE Municipal Solid-State Street Lighting Consortium shares technical information and experiences related to LED street and area lighting demonstrations and serves as an objective resource for evaluating new products on the market intended for those applications. Cities, power providers, and others who invest in street and area lighting are invited to join the Consortium and share their

  3. DOE - Office of Legacy Management -- Oliver Corp - MI 11

    Office of Legacy Management (LM)

    OLIVER CORP. (MI.11 ) Eliminated from further consideration under FUSRAP - Referred to NRC Designated Name: Not Designated Alternate Name: Behnke Warehousing Incorporated MI.11-1...

  4. Superfund Record of Decision (EPA Region 2): Love Canal (93rd Street School), Niagara County, City of Niagara Falls, NY. (Third remedial action), (amendment), May 1991. Final report

    SciTech Connect

    Not Available

    1991-05-15

    The Love Canal (93rd Street) site is an inactive hazardous waste site located in Niagara Falls, New York. The 19-acre 93rd Street School site, one of several operable units for the Love Canal Superfund site, is the focus of the Record of Decision (ROD). The fill material is reported to contain fly ash and BHC (a pesticide) waste. The ROD amends the 1988 ROD, and addresses final remediation of onsite contaminated soil through excavation and offsite disposal. The primary contaminants of concern affecting the soil are VOCs including toluene and xylenes; other organics including PAHs and pesticides; and metals including arsenic, chromium, and lead.

  5. Pecan Street Grid Demonstration Program. Final technology performance report

    SciTech Connect

    None, None

    2015-02-10

    This document represents the final Regional Demonstration Project Technical Performance Report (TPR) for Pecan Street Inc.’s (Pecan Street) Smart Grid Demonstration Program, DE-OE-0000219. Pecan Street is a 501(c)(3) smart grid/clean energy research and development organization headquartered at The University of Texas at Austin (UT). Pecan Street worked in collaboration with Austin Energy, UT, Environmental Defense Fund (EDF), the City of Austin, the Austin Chamber of Commerce and selected consultants, contractors, and vendors to take a more detailed look at the energy load of residential and small commercial properties while the power industry is undergoing modernization. The Pecan Street Smart Grid Demonstration Program signed-up over 1,000 participants who are sharing their home or businesses’s electricity consumption data with the project via green button protocols, smart meters, and/or a home energy monitoring system (HEMS). Pecan Street completed the installation of HEMS in 750 homes and 25 commercial properties. The program provided incentives to increase the installed base of roof-top solar photovoltaic (PV) systems, plug-in electric vehicles with Level 2 charging, and smart appliances. Over 200 participants within a one square mile area took advantage of Austin Energy and Pecan Street’s joint PV incentive program and installed roof-top PV as part of this project. Of these homes, 69 purchased or leased an electric vehicle through Pecan Street’s PV rebate program and received a Level 2 charger from Pecan Street. Pecan Street studied the impacts of these technologies along with a variety of consumer behavior interventions, including pricing models, real-time feedback on energy use, incentive programs, and messaging, as well as the corresponding impacts on Austin Energy’s distribution assets.The primary demonstration site was the Mueller community in Austin, Texas. The Mueller development, located less than three miles from the Texas State Capitol

  6. The NuMI neutrino beam

    DOE PAGES [OSTI]

    Adamson, P.; Anderson, K.; Andrews, M.; Andrews, R.; Anghel, I.; Augustine, D.; Aurisano, A.; Avvakumov, S.; Ayres, D. S.; Baller, B.; et al

    2015-10-20

    Our paper describes the hardware and operations of the Neutrinos at the Main Injector (NuMI) beam at Fermilab. It elaborates on the design considerations for the beam as a whole and for individual elements. The most important part of our design details pertaining to individual components is described. Beam monitoring systems and procedures, including the tuning and alignment of the beam and NuMI long-term performance, are also discussed.

  7. The NuMI Neutrino Beam

    SciTech Connect

    Adamson, P.; Anderson, K.; Andrews, M.; Andrews, R.; Anghel, I.; Augustine, D.; Aurisano, A.; Avvakumov, S.; Ayres, D. S.; Baller, B.; Barish, B.; Barr, G.; Barrett, W. L.; Berstein, R. H.; Biggs, J.; Bishai, M.; Blake, A.; Bocean, V.; Bock, G. J.; Boehnlein, D. J.; Bogert, D.; Bourkland, K.; Cao, S. V.; Castromonte, C. M.; Childress, S.; Choudhary, B. C.; Coelho, J. A.B.; Cobb, J. H.; Corwin, L.; Crane, D.; Cravens, J. P.; Cronin-Hennessy, D.; Ducar, R. J.; De Jong, J. K.; Devan, A. V.; Devenish, N. E.; Diwan, M. V.; Erwin, A. R.; Escobar, C. O.; Evans, J. J.; Falk, E.; Feldman, G. J.; Fields, T. H.; Ford, R.; Frohne, M. V.; Gallahger, H. R.; Garkusha, V.; Gomes, R. A.; Goodman, M. C.; Gouffon, P.; Graf, N.; Gran, R.; Grossman, N.; Grzelak, K.; Habig, A.; Hahn, S. R.; Harding, D.; Harris, D.; Harris, P. G.; Hartnell, J.; Hatcher, R.; Hays, S.; Heller, K.; Holin, A.; Huang, J.; Hylen, J.; Ibrahim, A.; Indurthy, D.; Irwin, G. M.; Isvan, Z.; Jaffe, D. E.; James, C.; Jensen, D.; Johnstone, J.; Kafka, T.; Kasahara, S. M.S.; Koizumi, G.; Kopp, S.; Kordosky, M.; Kreymer, A.; Lang, K.; Laughton, C.; Lefeuvre, G.; Ling, J.; Litchfield, P. J.; Loiacono, L.; Lucas, P.; Mann, W. A.; Marchionni, A.; Marshak, M. L.; Mayer, N.; McGivern, C.; Medeiros, M. M.; Mehdiyev, R.; Meier, J. R.; Messier, M. D.; Michael, D. G.; Milburn, R. H.; Miller, J. L.; Miller, W. H.; Mishra, S. R.; Sher, S. Moed; Moore, C. D.; Morfin, J.; Mualem, L.; Mufson, S.; Murgia, S.; Murtagh, M.; Musser, J.; Naples, D.; Nelson, J. K.; Newman, H. B.; Nichol, R. J.; Nowak, J. A.; O'connor, J.; Oliver, W. P.; Olsen, M.; Orchanian, M.; Osprey, S.; Pahlka, R. B.; Paley, J.; Para, A.; Patterson, R. B.; Patzak, T.; Pavlovic, Z.; Pawloski, G.; Perch, A.; Peterson, E. A.; Petyt, D. A.; Pfutzner, M. M.; Phan-Budd, S.; Plunkett, R. K.; Poonthottathil, N.; Prieto, P.; Pushka, D.; Qiu, X.; Radovic, A.; Rameika, R. A.; Ratchford, J.; Rebel, B.; Reilly, R.; Rosenfeld, C.; Rubin, H. A.; Ruddick, K.; Sanchez, M. C.; Saoulidou, N.; Sauer, L.; Schneps, J.; Schoo, D.; Schreckenberger, A.; Schreiner, P.; Shanahan, P.; Sharma, R.; Smart, W.; Smith, C.; Sousa, A.; Stefanik, A.; Tagg, N.; Talaga, R. L.; Tassotto, G.; Thomas, J.; Thompson, J.; Thomson, M. A.; Tian, X.; Timmons, A.; Tinsley, D.; Tognini, S. C.; Toner, R.; Torretta, D.; Trostin, I.; Tzanakos, G.; Urheim, J.; Vahle, P.; Vaziri, K.; Villegas, E.; Viren, B.; Vogel, G.; Webber, R. C.; Weber, A.; Webb, R. C.; Wehmann, A.; White, C.; Whitehead, L.; Whitehead, L. H.; Wojcicki, S. G.; Wong-Squires, M. L.; Yang, T.; Yumiceva, F. X.; Zarucheisky, V.; Zwaska, R.

    2015-10-20

    Our paper describes the hardware and operations of the Neutrinos at the Main Injector (NuMI) beam at Fermilab. It elaborates on the design considerations for the beam as a whole and for individual elements. The most important part of our design details pertaining to individual components is described. Beam monitoring systems and procedures, including the tuning and alignment of the beam and NuMI long-term performance, are also discussed.

  8. C:\\PERFORM\\FORMS\\S1445.FRP

    Energy.gov [DOE] (indexed site)

    FIRST NAME MI STREET ADDRESS CITY STATE ZIP CODE WORK CLASSIFICATION WAGE RATE NAME OF PRIME CONTRACTOR NAME OF EMPLOYER SUPERVISOR'S NAME LAST NAME FIRST NAME MI ACTION CHECK...

  9. State of the Lab Address

    ScienceCinema

    King, Alex

    2016-07-12

    In his third-annual State of the Lab address, Ames Laboratory Director Alex King called the past year one of "quiet but strong progress" and called for Ames Laboratory to continue to build on its strengths while responding to changing expectations for energy research.

  10. Member Case Studies: LED Street Lighting Programs in Algona (IA), Asheville (NC), and Boston (MA)

    Energy.gov [DOE]

    This May 8, 2013 webcast featured presentations from DOE Municipal Solid-State Street Lighting Consortium member cities about their experiences with LED street lighting. Presenters John Bilsten of...

  11. Demonstration Assessment of Light Emitting Diode (LED) Street Lighting, Phase III Continuation

    SciTech Connect

    Cook, Tyson; Shackelford, Jordan; Johnson, Megan; Pang, Terrance

    2008-11-01

    This report summarizes the third phase of an LED street lighting assessment project in Oakland, California, conducted to study the applicability of LED luminaires in a street lighting application.

  12. Text-Alternative Version: Keynote Video from Street and Area Lighting Conference

    Office of Energy Efficiency and Renewable Energy (EERE)

    Following is a text version of Jim Brodrick's keynote video from the recent Street and Area Lighting Conference.

  13. Webinar: Get the Facts on LED Street Lighting | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Get the Facts on LED Street Lighting Webinar: Get the Facts on LED Street Lighting During this October 20, 2016 webinar, Bruce Kinzey of Pacific Northwest National Laboratory examined key issues underlying concerns raised by the American Medical Association community guidance on street lighting, and their applicability to LED street lighting. The presentation also provided essential background context related to exposure to light at night and reviewed activities currently being supported by the

  14. DOE Tour of Zero Floorplans: 5th Street Deep Rehab by Carl Franklin Homes &

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Green Extreme Homes | Department of Energy 5th Street Deep Rehab by Carl Franklin Homes & Green Extreme Homes DOE Tour of Zero Floorplans: 5th Street Deep Rehab by Carl Franklin Homes & Green Extreme Homes DOE Tour of Zero Floorplans: 5th Street Deep Rehab by Carl Franklin Homes & Green Extreme Homes

  15. Addressing Deferred Maintenance, Infrastructure Costs, and Excess...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Addressing Deferred Maintenance, Infrastructure Costs, and Excess Facilities at Portsmouth and Paducah Addressing Deferred Maintenance, Infrastructure Costs, and Excess Facilities ...

  16. Agenda: Enhancing Energy Infrastructure Resiliency and Addressing...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Agenda: Enhancing Energy Infrastructure Resiliency and Addressing Vulnerabilities Agenda: Enhancing Energy Infrastructure Resiliency and Addressing Vulnerabilities A Public Meeting ...

  17. Addressing the workforce pipeline challenge

    SciTech Connect

    Leonard Bond; Kevin Kostelnik; Richard Holman

    2006-11-01

    A secure and affordable energy supply is essential for achieving U.S. national security, in continuing U.S. prosperity and in laying the foundations to enable future economic growth. To meet this goal the next generation energy workforce in the U.S., in particular those needed to support instrumentation, controls and advanced operations and maintenance, is a critical element. The workforce is aging and a new workforce pipeline, to support both current generation and new build has yet to be established. The paper reviews the challenges and some actions being taken to address this need.

  18. STREET CENTR AL AVENU E C E N T R A L A

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    7 6 15 18 19 17 20 21 23 24 25 20TH STREET CENTR AL AVENU E C E N T R A L A V E N U E CENT RAL AVEN UE CAN YO N RO AD IRIS STREET N E C T A R S T R E E T M YR TL E ST RE ET 15TH STREET 4TH STREET 6TH STREET TRINITY DRIVE DP ROAD T R I N I T Y D R I V E TRINITY DRIVE T R I N I T Y D R I V E O P P E N H E I M E R D R I V E POST OFFICE CHAMBER OF COMMERCE BRADBURY SCIENCE MUSEUM BUS PARKING FULLER LODGE ASHLEY POND HISTORICAL MUSEUM MESA PUBLIC LIBRARY SENIOR CENTER KNECHT STREET 9TH STREET 16 14

  19. Hydraulic Capacity of an ADA Compliant Street Drain Grate

    SciTech Connect

    Lottes, Steven A.; Bojanowski, Cezary

    2015-09-01

    Resurfacing of urban roads with concurrent repairs and replacement of sections of curb and sidewalk may require pedestrian ramps that are compliant with the American Disabilities Act (ADA), and when street drains are in close proximity to the walkway, ADA compliant street grates may also be required. The Minnesota Department of Transportation ADA Operations Unit identified a foundry with an available grate that meets ADA requirements. Argonne National Laboratory’s Transportation Research and Analysis Computing Center used full scale three dimensional computational fluid dynamics to determine the performance of the ADA compliant grate and compared it to that of a standard vane grate. Analysis of a parametric set of cases was carried out, including variation in longitudinal, gutter, and cross street slopes and the water spread from the curb. The performance of the grates was characterized by the fraction of the total volume flow approaching the grate from the upstream that was captured by the grate and diverted into the catch basin. The fraction of the total flow entering over the grate from the side and the fraction of flow directly over a grate diverted into the catch basin were also quantities of interest that aid in understanding the differences in performance of the grates. The ADA compliant grate performance lagged that of the vane grate, increasingly so as upstream Reynolds number increased. The major factor leading to the performance difference between the two grates was the fraction of flow directly over the grates that is captured by the grates.

  20. Port Huron, MI Liquefied Natural Gas Exports to Canada (Million...

    Energy Information Administration (EIA) (indexed site)

    Huron, MI Liquefied Natural Gas Exports to Canada (Million Cubic Feet) Port Huron, MI Liquefied Natural Gas Exports to Canada (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul ...

  1. DOE - Office of Legacy Management -- Naval Ordnance Plant - MI...

    Office of Legacy Management (LM)

    Eliminated from further consideration under FUSRAP - Referred to DoD for action Designated ... MI.0-03-1 Site Disposition: Eliminated - No Authority - Referred to DoD MI.0-03-1 ...

  2. miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor

    SciTech Connect

    Park, Jong-Kook; Henry, Jon C.; Jiang, Jinmai; Esau, Christine; Gusev, Yuriy; Lerner, Megan R.; Postier, Russell G.; Brackett, Daniel J.; Schmittgen, Thomas D.

    2011-03-25

    Research highlights: {yields} The expression of miR-132 and miR-212 are significantly increased in pancreatic cancer. {yields} miR-132 and miR-212 target the tumor suppressor pRb, resulting in enhanced proliferation. {yields} miR-132 and miR-212 expression is increased by a {beta}2 adrenergic receptor agonist, suggesting a novel mechanism for pancreatic cancer progression. -- Abstract: Numerous microRNAs (miRNAs) are reported as differentially expressed in cancer, however the consequence of miRNA deregulation in cancer is unknown for many miRNAs. We report that two miRNAs located on chromosome 17p13, miR-132 and miR-212, are over-expressed in pancreatic adenocarcinoma (PDAC) tissues. Both miRNAs are predicted to target the retinoblastoma tumor suppressor, Rb1. Validation of this interaction was confirmed by luciferase reporter assay and western blot in a pancreatic cancer cell line transfected with pre-miR-212 and pre-miR-132 oligos. Cell proliferation was enhanced in Panc-1 cells transfected with pre-miR-132/-212 oligos. Conversely, antisense oligos to miR-132/-212 reduced cell proliferation and caused a G{sub 2}/M cell cycle arrest. The mRNA of a number of E2F transcriptional targets were increased in cells over expressing miR-132/-212. Exposing Panc-1 cells to the {beta}2 adrenergic receptor agonist, terbutaline, increased the miR-132 and miR-212 expression by 2- to 4-fold. We report that over-expression of miR-132 and miR-212 result in reduced pRb protein in pancreatic cancer cells and that the increase in cell proliferation from over-expression of these miRNAs is likely due to increased expression of several E2F target genes. The {beta}2 adrenergic pathway may play an important role in this novel mechanism.

  3. Addressing Failures in Exascale Computing

    SciTech Connect

    Snir, Marc; Wisniewski, Robert; Abraham, Jacob; Adve, Sarita; Bagchi, Saurabh; Balaji, Pavan; Belak, J.; Bose, Pradip; Cappello, Franck; Carlson, Bill; Chien, Andrew; Coteus, Paul; DeBardeleben, Nathan; Diniz, Pedro; Engelmann, Christian; Erez, Mattan; Fazzari, Saverio; Geist, Al; Gupta, Rinku; Johnson, Fred; Krishnamoorthy, Sriram; Leyffer, Sven; Liberty, Dean; Mitra, Subhasish; Munson, Todd; Schreiber, Rob; Stearley, Jon; Van Hensbergen, Eric

    2014-01-01

    We present here a report produced by a workshop on Addressing failures in exascale computing' held in Park City, Utah, 4-11 August 2012. The charter of this workshop was to establish a common taxonomy about resilience across all the levels in a computing system, discuss existing knowledge on resilience across the various hardware and software layers of an exascale system, and build on those results, examining potential solutions from both a hardware and software perspective and focusing on a combined approach. The workshop brought together participants with expertise in applications, system software, and hardware; they came from industry, government, and academia, and their interests ranged from theory to implementation. The combination allowed broad and comprehensive discussions and led to this document, which summarizes and builds on those discussions.

  4. Addressing failures in exascale computing

    SciTech Connect

    Snir, Marc; Wisniewski, Robert W.; Abraham, Jacob A.; Adve, Sarita; Bagchi, Saurabh; Balaji, Pavan; Belak, Jim; Bose, Pradip; Cappello, Franck; Carlson, William; Chien, Andrew A.; Coteus, Paul; Debardeleben, Nathan A.; Diniz, Pedro; Engelmann, Christian; Erez, Mattan; Saverio, Fazzari; Geist, Al; Gupta, Rinku; Johnson, Fred; Krishnamoorthy, Sriram; Leyffer, Sven; Liberty, Dean; Mitra, Subhasish; Munson, Todd; Schreiber, Robert; Stearly, Jon; Van Hensbergen, Eric

    2014-05-01

    We present here a report produced by a workshop on “Addressing Failures in Exascale Computing” held in Park City, Utah, August 4–11, 2012. The charter of this workshop was to establish a common taxonomy about resilience across all the levels in a computing system; discuss existing knowledge on resilience across the various hardware and software layers of an exascale system; and build on those results, examining potential solutions from both a hardware and software perspective and focusing on a combined approach. The workshop brought together participants with expertise in applications, system software, and hardware; they came from industry, government, and academia; and their interests ranged from theory to implementation. The combination allowed broad and comprehensive discussions and led to this document, which summarizes and builds on those discussions.

  5. “Nodal Gap” induced by the incommensurate diagonal spin density modulation in underdoped high- <mi>Tmi>c> superconductors

    SciTech Connect

    Zhou, Tao; Gao, Yi; Zhu, Jian -Xin

    2015-03-07

    Recently it was revealed that the whole Fermi surface is fully gapped for several families of underdoped cuprates. The existence of the finite energy gap along the <mi>d>-wave nodal lines (nodal gap) contrasts the common understanding of the <mi>d>-wave pairing symmetry, which challenges the present theories for the high-<mi>Tmi><mi>c>superconductors. Here we propose that the incommensurate diagonal spin-density-wave order can account for the above experimental observation. The Fermi surface and the local density of states are also studied. Our results are in good agreement with many important experiments in high-<mi>Tmi><mi>c>superconductors.

  6. JLab Test Public Address System | Jefferson Lab

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Test Public Address System May 18 at 5:30 p.m.: JLab Will Test its Public Address System On Wednesday, May 18, Jefferson Lab will conduct the monthly test of its Public Address ...

  7. Name Name Address Place Zip Category Sector Telephone number...

    OpenEI (Open Energy Information) [EERE & EIA]

    Hydro Marine and Hydrokinetic http acep uaf edu facilities tanana river hydrokinetic test site aspx Alden Research Laboratory Inc Alden Research Laboratory Inc Shrewsbury Street...

  8. Keynote Address: Update on Environmental Management | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Address: Update on Environmental Management Keynote Address: Update on Environmental Management Keynote presentation made by David G. Huizenga for the NTSF annual meeting held from ...

  9. EPA -- Addressing Children's Health through Reviews Conducted...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    EPA -- Addressing Children's Health through Reviews Conducted Pursuant to the National Environmental Policy Act and Section 309 of the Clean Air Act EPA -- Addressing Children's ...

  10. Deputy Secretary Poneman Addresses Nuclear Deterrence Summit...

    Office of Environmental Management (EM)

    Addresses Nuclear Deterrence Summit Deputy Secretary Poneman Addresses Nuclear Deterrence Summit February 17, 2010 - 12:00am Addthis Alexandria, VA - U.S. Deputy Secretary of ...

  11. Characterization of function and regulation of miR-24-1 and miR-31

    SciTech Connect

    Sun Fenyong; Wang Jiayi; Pan Qiuhui; Yu Yongchun; Zhang Yue; Wan Yang; Wang Ju; Li Xiaoyan; Hong An

    2009-03-13

    To date, numerous microRNAs (miRNAs) have been discovered. However, the function of these miRNAs is largely unknown. While our knowledge of miRNA post-transcriptional processing has greatly expanded in recent years, we have a limited understanding of the regulation and transcription of miRNA genes. In this study, we characterized two BMP-2 upregulated miRNAs, miR-24-1 and miR-31, in mesenchymal stem cells and showed their opposing function in controlling cellular proliferation, and adipogenesis. Furthermore, we are the first to identify and characterize mouse intronic miR-23b{approx}27b{approx}24-1 and intergenic miR-31 genes. Moreover, we found that pri-miR-23b, pri-miR-27b, and pri-miR-24-1 are transcribed independently and their expression profiles are unique when cells are treated with BMP-2, even though they are located closely together.

  12. Major prime contractors have developed a plan to address Hanford Beryllium exposure and are continuing to improve the Chronic Beryllium Disease Prevention Plan (CBDPP)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    OMC-CS-532H Rev. 2 Published 05/05/16 Beryllium Information Booklet Beryllium Information Provided By: HPMC Occupational Medical Services http://www.hanford.gov/health/ Physical Address: MSIN G3-70 1979 Snyder Street, Suite 150 Richland, WA 99354 Mailing Address: P.O. Box 150 Richland, WA 99352 HPMC Occupational Medical Services - Beryllium Information Booklet OMC-CS-532H Rev. 2 Published 05/05/16 1 Table of Contents Disclaimer

  13. The Recovery Act is "Lighting Up" the streets of Philadelphia

    ScienceCinema

    Nutter, Michael; Gajewski, Katherine; Russell, Toby; Williams, Doug; Best, DeLain

    2016-07-12

    The Philadelphia Streets Department is converting 58,000 yellow and green traffic signals and will replace approximately 27,000 red LED lights that have come to the end of their useful life. The project will use approximately $3 million in EECBG funds, matched with $3 million in PECO funding, and will save the city approximately $1 million in electric costs each year. For more information on Recovery Act projects funded by the Department of Energy in Pennsylvania: http://www.energy.gov/recovery/pa.htm

  14. The Recovery Act is "Lighting Up" the streets of Philadelphia

    SciTech Connect

    Nutter, Michael; Gajewski, Katherine; Russell, Toby; Williams, Doug; Best, DeLain;

    2010-01-01

    The Philadelphia Streets Department is converting 58,000 yellow and green traffic signals and will replace approximately 27,000 red LED lights that have come to the end of their useful life. The project will use approximately $3 million in EECBG funds, matched with $3 million in PECO funding, and will save the city approximately $1 million in electric costs each year. For more information on Recovery Act projects funded by the Department of Energy in Pennsylvania: http://www.energy.gov/recovery/pa.htm

  15. POLICY GUIDANCE MEMORANDUM #03 Addressing Missclassified Positions |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy 3 Addressing Missclassified Positions POLICY GUIDANCE MEMORANDUM #03 Addressing Missclassified Positions This memorandum provides policy guidance on how to consistently address misclassified positions within the Department and is effective immediately. There are several different circumstances that affect how a misclassified position will be addressed. POLICY GUIDANCE MEMORANDUM #3A Addressing Missclassified Positions (77.5 KB) Responsible Contacts Jennifer Ackerman

  16. Demonstration of LED Street Lighting in Kansas City, MO (Technical Report)

    Office of Scientific and Technical Information (OSTI)

    | SciTech Connect Demonstration of LED Street Lighting in Kansas City, MO Citation Details In-Document Search Title: Demonstration of LED Street Lighting in Kansas City, MO Nine different streetlighting products were installed on various streets in Kansas City, Missouri during February, 2011, to evaluate their performance relative to the incumbent high-pressure sodium (HPS) lighting. The applications investigated included 100 W, 150 W, 250 W, and 400 W HPS installations. Initial measurements

  17. Text-Alternative Version: MSSLC Member Case Studies - LED Street Lighting

    Energy Saver

    Programs Webinar | Department of Energy MSSLC Member Case Studies - LED Street Lighting Programs Webinar Text-Alternative Version: MSSLC Member Case Studies - LED Street Lighting Programs Webinar Below is the text-alternative version of the "MSSLC Member Case Studies - LED Street Lighting Programs" webcast, held May 8, 2013. Edward Smalley: Good morning. Welcome ladies and gentlemen. I'm Edward Smalley with Seattle City Light, Seattle's publicly-owned utility. As Director of the

  18. Text-Alternative Version: Municipal Solid-State Street Lighting Consortium

    Energy Saver

    Kickoff | Department of Energy Kickoff Text-Alternative Version: Municipal Solid-State Street Lighting Consortium Kickoff Below is the text-alternative version of the Municipal Solid-State Street Lighting Consortium Kickoff webcast, held May 6, 2010. Terry Shoemaker: Welcome, ladies and gentlemen. I'm Terry Shoemaker with the Pacific Northwest National Laboratory, and I'd like to welcome you to today's webcast, Municipal Solid-State Street Lighting Consortium Kickoff Meeting. This is brought

  19. Text-Alternative Version: Using the Street and Parking Facility Lighting

    Energy Saver

    Retrofit Financial Analysis Tool | Department of Energy Using the Street and Parking Facility Lighting Retrofit Financial Analysis Tool Text-Alternative Version: Using the Street and Parking Facility Lighting Retrofit Financial Analysis Tool Below is the text-alternative version of the "Using the Street and Parking Facility Lighting Retrofit Financial Analysis Tool" webcast, held August 22, 2013. Jeff McCullough: Welcome ladies and gentlemen. My name is Jeff McCullough with the

  20. Secretary Chu Op-Ed on Small Modular Reactors in the Wall Street Journal |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Small Modular Reactors in the Wall Street Journal Secretary Chu Op-Ed on Small Modular Reactors in the Wall Street Journal March 23, 2010 - 12:00am Addthis Washington, D.C. - Today, the Wall Street Journal published an op-ed by U.S. Secretary of Energy Steven Chu on small modular reactors. The op-ed can be viewed on the Wall Street Journal. The text of the op-ed is below: America's New Nuclear Option Small modular reactors will expand the ways we use atomic power. By

  1. Secretary Chu's Op-Ed on Small Modular Reactors in the Wall Street Journal

    Energy.gov [DOE]

    The Wall Street Journal published an op-ed by U.S. Secretary of Energy Steven Chu on small modular reactors.

  2. Text-Alternative Version: Municipal Solid-State Street Lighting Consortium Retrofit Financial Analysis Tool Webcast

    Office of Energy Efficiency and Renewable Energy (EERE)

    Below is the text-alternative version of the "Municipal Solid-State Street Lighting Consortium Retrofit Financial Analysis Tool" webcast, held April 3, 2012.

  3. Address conversion unit for multiprocessor system

    SciTech Connect

    Fava, T.F.; Lary, R.F.; Blackledge, R.

    1987-03-03

    An address conversion unit is described for use in one processor in a multi-processor data processing system including a common memory, the processors and common memory being interconnected by a common bus including means for transferring address signals defining a common address space. The processor includes private bus means including means for transferring signals including address signals defining a private address space. A processor unit means is connected to the private bus means and includes means for transmitting and receiving signals including address signals over the private bus means for engaging in data transfers thereover. The address conversion unit is connected to the private bus means and common bus means for receiving address signals over the private bus means from the processor unit means in the private address space. The unit comprises: A. pointer storage means for storing a pointer identifying a portion of the common bus memory space; B. pointer generation means connected to receive a common bus address and for generating a pointer in response thereto for storage in the pointer storage means; and C. common bus address generation means connected to the private bus and the pointer storage means for receiving an address from the processor unit means and for generating a common bus address in response thereto. The common bus address is used to initiate transfers between the processor unit means and the common memory over the common bus.

  4. Keynote Address: Future Vision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Future Vision Keynote Address: Future Vision May 20, 2014 1:00PM to 1:30PM PDT Pacific Ballroom Tuesday's keynote address by Raffi Garabedian, Chief Technology Officer, First Solar

  5. Magnetocrystalline anisotropy in <mi>UMn>2<mi>Ge>2 and related Mn-based actinide ferromagnets

    SciTech Connect

    Parker, David S.; Ghimire, Nirmal; Singleton, John; Thompson, J. D.; Bauer, Eric D.; Baumbach, Ryan; Mandrus, David; Li, Ling; Singh, David J.

    2015-05-04

    We present magnetization isotherms in pulsed magnetic fields up to 62 Tesla, supported by first principles calculations, demonstrating a huge uniaxial magnetocrystalline anisotropy energy - approximately 20 MJ/m3 - in <mi>UMn>2<mi>Ge>2. This large anisotropy results from the extremely strong spin-orbit coupling affecting the uranium 5 f electrons, which in the calculations exhibit a substantial orbital moment exceeding 2 μB. Finally, we also find from theoretical calculations that a number of isostructural Mn-actinide compounds are expected to have similarly large anisotropy.

  6. DOE - Office of Legacy Management -- Star Cutter Corp - MI 15

    Office of Legacy Management (LM)

    Eliminated - Potential for contamination considered remote based on limited scope and quantity of materials handled MI.15-2 Radioactive Materials Handled: Yes Primary ...

  7. MINOS Experiment and NuMI Beam Home Page

    U.S. Department of Energy (DOE) - all webpages

    NuMI-MINOS Neutrino Logo NuMI Beamline and MINOS Experiment Neutrino Logo The MINOS Experiment and NuMI Beamline Fermilab Logo MINOS Experiment Links ◊ MINOS for the Public ◊ Scientific Results ◊ MINOS at Work ◊ NuMI at Work ◊ MINOS+ Experiment Fermilab Neutrino Links ◊ Neutrino FAQ ◊ MINOS Underground Areas at Fermilab ◊ PPD Intensity Frontier Dept Back to - - - ◊ Fermilab at Work ◊ Fermilab Home the MINOS Far Detector in the Soudan Mine MINOS collaborators assembling the

  8. Superfund record of decision amendment (EPA Region 2): Hooker (102nd Street Landfill), Niagara Falls, NY, June 9, 1995

    SciTech Connect

    1995-08-01

    This decision document presents the selected modification to the original remedial action (PB91-921417) for the 102nd Street Landfill Site (the `Site`), located in Niagara Falls, New York. The modification to the selected remedy addresses the river sediments within the shallow embayment of the Niagara River adjacent to the Site. The major components of the modification to the selected remedy include: dredging the Niagara River sediments to the `clean line` with respect to Site-related contamination. These sediments, after dewatering, will NOT be incinerated, but will be consolidated on the landfill. Any NAPL found within these sediments will be extracted, and will be incinerated at an off-site facility.

  9. Mailing Addresses for National Laboratories and Technology Centers...

    Energy Saver

    Fermi National Accelerator Laboratory Kirk Road & Pine Street Batavia, IL 60510-0500 ... Power Laboratory P.O. Box 1072 2401 River Road Niskayuna, NY 12309 518-395-4000 U.S. ...

  10. Report Outlines Promising Opportunities for Addressing Climate...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Report Outlines Promising Opportunities for Addressing Climate Change For more information contact: George Douglas, 303-275-4096 email: George Douglas Golden, Colo., Nov. 15, 2000 ...

  11. Addressing Challenges of Identifying Geometrically Diverse Sets...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Addressing Challenges of Identifying Geometrically Diverse Sets of Crystalline Porous Materials Previous Next List R. L. Martin, B. Smit, and M. Haranczyk, J. Chem Inf. Model. 52...

  12. Multithreaded Global Address Space Communication Techniques

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Multithreaded Global Address Space Communication Techniques for Gyrokinetic Fusion ... of high communication work loads of the underlying kernel among OpenMP threads. ...

  13. Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells

    SciTech Connect

    Vrba, Lukas; Jensen, Taylor J.; Garbe, James C.; Heimark, Ronald L.; Cress, Anne E.; Dickinson, Sally; Stampfer, Martha R.; Futscher, Bernard W.

    2009-12-23

    BACKGROUND: The microRNA-200 family participates in the maintenance of an epithelial phenotype and loss of its expression can result in epithelial to mesenchymal transition (EMT). Furthermore, the loss of expression of miR-200 family members is linked to an aggressive cancer phenotype. Regulation of the miR-200 family expression in normal and cancer cells is not fully understood. METHODOLOGY/ PRINCIPAL FINDINGS: Epigenetic mechanisms participate in the control of miR-200c and miR-141 expression in both normal and cancer cells. A CpG island near the predicted mir-200c/mir-141 transcription start site shows a striking correlation between miR-200c and miR-141 expression and DNA methylation in both normal and cancer cells, as determined by MassARRAY technology. The CpG island is unmethylated in human miR-200/miR-141 expressing epithelial cells and in miR-200c/miR-141 positive tumor cells. The CpG island is heavily methylated in human miR-200c/miR-141 negative fibroblasts and miR-200c/miR-141 negative tumor cells. Mouse cells show a similar inverse correlation between DNA methylation and miR-200c expression. Enrichment of permissive histone modifications, H3 acetylation and H3K4 trimethylation, is seen in normal miR-200c/miR-141-positive epithelial cells, as determined by chromatin immunoprecipitation coupled to real-time PCR. In contrast, repressive H3K9 dimethylation marks are present in normal miR-200c/miR-141-negative fibroblasts and miR-200c/miR-141 negative cancer cells and the permissive histone modifications are absent. The epigenetic modifier drug, 5-aza-2'-deoxycytidine, reactivates miR-200c/miR-141 expression showing that epigenetic mechanisms play a functional role in their transcriptional control. CONCLUSIONS/ SIGNIFICANCE: We report that DNA methylation plays a role in the normal cell type-specific expression of miR-200c and miR-141 and this role appears evolutionarily conserved, since similar results were obtained in mouse. Aberrant DNA methylation of the

  14. DOE Zero Energy Ready Home Case Study: M Street Homes, Houston, TX |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy M Street Homes, Houston, TX DOE Zero Energy Ready Home Case Study: M Street Homes, Houston, TX DOE Zero Energy Ready Home Case Study: M Street Homes, Houston, TX Case study of a DOE Zero Energy Ready home in Houston, TX, that achieves a HERS 45 without PV or HERS 32 with 1.2 kW PV. The three-story, 4,507-ft2 custom home is powered by a unique tri-generation system that supplies all of the home's electricity, heating, and cooling on site. The tri-generator is powered by a

  15. Using QECBs for Street Lighting Upgrades: Lighting the Way to Lower Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Bills in San Diego | Department of Energy QECBs for Street Lighting Upgrades: Lighting the Way to Lower Energy Bills in San Diego Using QECBs for Street Lighting Upgrades: Lighting the Way to Lower Energy Bills in San Diego Summarizes how the City of San Diego leveraged $13.1 million in qualified energy conservation bonds to increase the size of a street lighting upgrade project. Author: Lawrence Berkeley National Laboratory Lighting the Way to Lower Energy Bills in San Diego (322.66 KB)

  16. Demonstration of LED Street Lighting in Kansas City, MO

    SciTech Connect

    Kinzey, Bruce R.; Royer, Michael P.; Hadjian, M.; Kauffman, Rick

    2013-06-10

    Nine different streetlighting products were installed on various streets in Kansas City, Missouri during February, 2011, to evaluate their performance relative to the incumbent high-pressure sodium (HPS) lighting. The applications investigated included 100 W, 150 W, 250 W, and 400 W HPS installations. Initial measurements and comparisons included power, illuminance, and luminance; sample illuminance readings have continued at each of the nine locations at roughly 1,000-hour operating intervals since then. All of the LED products consumed less power than their HPS counterparts—with a mean difference of 39% and a range of 31% to 51%—but they also emitted 31% fewer lumens, on average. The net result is just a 15% increase in mean efficacy. Applying the city’s stringent light loss factors to the initial measured data meant that five of the LED products (and two of the HPS luminaires) were predicted to eventually fail to meet the specified mean illuminance over their lifetimes; however, the specified light loss levels are not expected to be reached by the LED products until some distant future date (between 12 and 30 years after installation according to manufacturer specification sheet estimates). The practical value of designing streetlighting systems to meet illumination requirements more than 15 years in the future is questioned. Numerous sources of variation in field measurements are noted throughout the report, particularly seasonal influences such as ambient temperature and foliage that are evident in the time-series illuminance data.

  17. miR-92a family and their target genes in tumorigenesis and metastasis

    SciTech Connect

    Li, Molin; Guan, Xingfang; Sun, Yuqiang; Mi, Jun; Shu, Xiaohong; Liu, Fang; Li, Chuangang

    2014-04-15

    The miR-92a family, including miR-25, miR-92a-1, miR-92a-2 and miR-363, arises from three different paralog clusters miR-17-92, miR-106a-363, and miR-106b-25 that are highly conservative in the process of evolution, and it was thought as a group of microRNAs (miRNAs) correlated with endothelial cells. Aberrant expression of miR-92a family was detected in multiple cancers, and the disturbance of miR-92a family was related with tumorigenesis and tumor development. In this review, the progress on the relationship between miR-92a family and their target genes and malignant tumors will be summarized. - Highlights: • Aberrant expression of miR-92a, miR-25 and miR-363 can be observed in many kinds of malignant tumors. • The expression of miR-92a family is regulated by LOH, epigenetic alteration, transcriptional factors such as SP1, MYC, E2F, wild-type p53 etc. • Roles of miR-92a family in tumorigenesis and development: promoting cell proliferation, invasion and metastasis, inhibiting cell apoptosis.

  18. SNR Denton US LLP 1301 K Street, NW Suite 600, East Tower Washington...

    Energy.gov [DOE] (indexed site)

    SNR Denton US LLP 1301 K Street, NW Suite 600, East Tower Washington, DC 20005-3364 USA Thomas C. Jensen Partner thomas.jensen@snrdenton.com D +1 202 408 3956 M 703 304 5211 T +1 ...

  19. DOE Zero Energy Ready Home Case Study: StreetScape Development, LLC, Libertyville, Illinois

    SciTech Connect

    none,

    2013-09-01

    These single-family, HERS 45 homes incorporate 2×6 wood framed walls with R-20 open cell spray insulation and OSB. The builder, StreetScape Development, won a 2013 Housing Innovation Award in the custom builder category.

  20. EECBG Success Story: Recovery Act is "Lighting Up" the Streets of Philadelphia

    Energy.gov [DOE]

    The Philadelphia Streets Department is converting 58,000 yellow and green traffic signals and will replace approximately 27,000 red LED lights that have come to the end of their useful life. Learn more.

  1. Making a One-Way Street for Electricity | U.S. DOE Office of Science (SC)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Making a One-Way Street for Electricity Basic Energy Sciences (BES) BES Home About Research Facilities Science Highlights Benefits of BES Funding Opportunities Basic Energy Sciences Advisory Committee (BESAC) Community Resources Contact Information Basic Energy Sciences U.S. Department of Energy SC-22/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3081 F: (301) 903-6594 E: Email Us More Information » 08.04.16 Making a One-Way Street for Electricity Scientists

  2. Building America Whole-House Solutions for Existing Homes: Conway Street

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Apartments - Greenfield, Massachusetts | Department of Energy Conway Street Apartments - Greenfield, Massachusetts Building America Whole-House Solutions for Existing Homes: Conway Street Apartments - Greenfield, Massachusetts Through recent research efforts, CARB has been evaluating strategies and technologies that can make dramatic improvements in energy performance in multifamily buildings. In this project, the team helped to transform a 100-year-old empty school building into 12 high

  3. Federal Actions to Address Impacts of Uranium

    Office of Legacy Management (LM)

    Federal Actions to Address Impacts of Uranium Contamination in the Navajo Nation 2014 Page | i TABLE OF CONTENTS Executive Summary ....................................................................................................................... 1 Introduction .................................................................................................................................... 2 Summary of Work Completed 2008-2012

  4. 2015 State of Indian Nations Address

    Energy.gov [DOE]

    The President of the National Congress of American Indians will deliver his annual State of the Indian Nations address to Member of Congress, government officials, tribal leaders and citizens, and...

  5. Rio Arriba Leadership Summit addresses challenges, opportunities

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    » Rio Arriba Leadership Summit addresses challenges, opportunities Community Connections: Your link to news and opportunities from Los Alamos National Laboratory Latest Issue:November 2, 2016 all issues All Issues » submit Rio Arriba Leadership Summit addresses challenges, opportunities Community leaders gather in Española for a round-table discussion. July 6, 2016 DOE's Office of Small and Disadvantaged Business Utilization presented Mentor and Protégé of the Year awards to LANS and RG

  6. Port Huron, MI Natural Gas Pipeline Imports From Canada (Million...

    Energy Information Administration (EIA) (indexed site)

    Million Cubic Feet) Port Huron, MI Natural Gas Pipeline Imports From Canada (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2016 262 - No Data Reported; ...

  7. miR-107 and miR-25 simultaneously target LATS2 and regulate proliferation and invasion of gastric adenocarcinoma (GAC) cells

    SciTech Connect

    Zhang, Mingjun; Wang, Xiaolei; Li, Wanhu; Cui, Yongchun

    2015-05-08

    Although a series of oncogenes and tumor suppressors were identified in the pathological development of gastric adenocarcinoma (GAC), the underlying molecule mechanism were still not fully understood. The current study explored the expression profile of miR-107 and miR-25 in GAC patients and their downstream regulative network. qRT-PCR analysis was performed to quantify the expression of these two miRNAs in serum samples from both patients and healthy controls. Dual luciferase assay was conducted to verify their putative bindings with LATS2. MTT assay, cell cycle assay and transwell assay were performed to explore how miR-107 and miR-25 regulate proliferation and invasion of gastric cancer cells. Findings of this study demonstrated that total miR-107 or miR-25 expression might be overexpressed in gastric cancer patients and they can simultaneously and synchronically regulate LATS2 expression, thereby affecting gastric cancer cell growth and invasion. Therefore, the miR-25/miR-107-LATS2 axis might play an important role in proliferation and invasion of the gastric cancer cells. - Highlights: • Total miR-107 and miR-25 expression is significantly increased in GAC patients. • Both miR-107 and miR-25 can promote proliferation and invasion of GAC cells. • Both miR-107 and miR-25 can target LATS2 and regulate its expression. • miR-107 and miR-25 regulate proliferation and invasion of GAC cells though LATS2.

  8. Cheaper Adjoints by Reversing Address Computations

    DOE PAGES [OSTI]

    Hascoët, L.; Utke, J.; Naumann, U.

    2008-01-01

    The reverse mode of automatic differentiation is widely used in science and engineering. A severe bottleneck for the performance of the reverse mode, however, is the necessity to recover certain intermediate values of the program in reverse order. Among these values are computed addresses, which traditionally are recovered through forward recomputation and storage in memory. We propose an alternative approach for recovery that uses inverse computation based on dependency information. Address storage constitutes a significant portion of the overall storage requirements. An example illustrates substantial gains that the proposed approach yields, and we show use cases in practical applications.

  9. Shared address collectives using counter mechanisms

    DOEpatents

    Blocksome, Michael; Dozsa, Gabor; Gooding, Thomas M; Heidelberger, Philip; Kumar, Sameer; Mamidala, Amith R; Miller, Douglas

    2014-02-18

    A shared address space on a compute node stores data received from a network and data to transmit to the network. The shared address space includes an application buffer that can be directly operated upon by a plurality of processes, for instance, running on different cores on the compute node. A shared counter is used for one or more of signaling arrival of the data across the plurality of processes running on the compute node, signaling completion of an operation performed by one or more of the plurality of processes, obtaining reservation slots by one or more of the plurality of processes, or combinations thereof.

  10. miR-17 inhibitor suppressed osteosarcoma tumor growth and metastasis via increasing PTEN expression

    SciTech Connect

    Gao, Yong; Luo, Ling-hui; Li, Shuai; Yang, Cao

    2014-02-07

    Highlights: • miR-17 was increased in OS tissues and cell lines. • Inhibition of miR-17 suppressed OS cell proliferation. • Inhibition of miR-17 suppressed OS cell migration and invasion. • PTEN was a target of miR-17. • miR-17 was negatively correlated with PTEN in OS tissues. - Abstract: MicroRNAs (miRNAs) play essential roles in cancer development and progression. Here, we investigated the role of miR-17 in the progression and metastasis of osteosarcoma (OS). miR-17 was frequently increased in OS tissues and cell lines. Inhibition of miR-17 in OS cell lines substantially suppressed cell proliferation, migration, and invasion. Phosphatase and tensin homolog (PTEN) was identified as a target of miR-17, and ectopic expression of miR-17 inhibited PTEN by direct binding to its 3′-untranslated region (3′-UTR). Expression of miR-17 was negatively correlated with PTEN in OS tissues. Together, these findings indicate that miR-17 acts as an oncogenic miRNA and may contribute to the progression and metastasis of OS, suggesting miR-17 as a potential novel diagnostic and therapeutic target of OS.

  11. Mapping virtual addresses to different physical addresses for value disambiguation for thread memory access requests

    SciTech Connect

    Gala, Alan; Ohmacht, Martin

    2014-09-02

    A multiprocessor system includes nodes. Each node includes a data path that includes a core, a TLB, and a first level cache implementing disambiguation. The system also includes at least one second level cache and a main memory. For thread memory access requests, the core uses an address associated with an instruction format of the core. The first level cache uses an address format related to the size of the main memory plus an offset corresponding to hardware thread meta data. The second level cache uses a physical main memory address plus software thread meta data to store the memory access request. The second level cache accesses the main memory using the physical address with neither the offset nor the thread meta data after resolving speculation. In short, this system includes mapping of a virtual address to a different physical addresses for value disambiguation for different threads.

  12. report2006.pdf

    Energy Saver

    POSITION TITLE MI FIRST NAME LAST NAME HOME ADDRESS (Street, City, State) EMPLOYER DOE ROUTE SYMBOL WORK PHONE EXT SIGNATURE ST CAR NO 1, MAKE TAG NUMBER ST TAG NUMBER CAR NO 2, MAKE YEARS FEDERAL SERVICE POSITION TITLE MI FIRST NAME LAST NAME HOME ADDRESS (Street, City, State) EMPLOYER DOE ROUTE SYMBOL WORK PHONE EXT INSTRUCTIONS: Complete requested information in each applicable blank. For make of car: Use Ford, Chevrolet, Plymouth, Toyota, Volkswagen, etc., Not model name. Return original

  13. parking permit application - front

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    POSITION TITLE MI FIRST NAME LAST NAME HOME ADDRESS (Street, City, State) EMPLOYER DOE ROUTE SYMBOL WORK PHONE EXT SIGNATURE ST CAR NO 1, MAKE TAG NUMBER ST TAG NUMBER CAR NO 2, MAKE YEARS FEDERAL SERVICE POSITION TITLE MI FIRST NAME LAST NAME HOME ADDRESS (Street, City, State) EMPLOYER DOE ROUTE SYMBOL WORK PHONE EXT INSTRUCTIONS: Complete requested information in each applicable blank. For make of car: Use Ford, Chevrolet, Plymouth, Toyota, Volkswagen, etc., Not model name. Return original

  14. District Energy Corporation SW 40th Street Thermal Energy Plant

    SciTech Connect

    Davlin, Thomas

    2014-06-06

    The overall deliverable from the project is the design, construction and commissioning of a detention facility heating and cooling system that minimizes ownership costs and maximizes efficiency (and therefore minimizes environmental impact). The primary deliverables were the proof of concept for the application of geothermal systems for an institutional facility and the ongoing, quarterly system operating data downloads to the Department of Energy . The primary advantage of geothermal based heat pump systems is the higher efficiency of the system compared to a conventional chiller, boiler, cooling tower based system. The higher efficiency results in a smaller environmental foot print and lower energy costs for the detention facility owner, Lancaster County. The higher efficiency for building cooling is primarily due to a more constant compressor condensing temperature with the geothermal well field acting as a thermal “sink” (in place of the conventional system’s cooling tower). In the heating mode, Ground Couple Heat Pump (GCHP) systems benefits from the advantage of a heat pump Coefficient of Performance (COP) of approximately 3.6, significantly better than a conventional gas boiler. The geothermal well field acting as a thermal “source” allows the heat pumps to operate efficiently in the heating mode regardless of ambient temperatures. The well field is partially located in a wetland with a high water table so, over time, the project will be able to identify the thermal loading characteristics of a well field located in a high water table location. The project demonstrated how a large geothermal well field can be installed in a wetland area in an economical and environmentally sound manner. Finally, the SW 40th Street Thermal Energy Plant project demonstrates the benefits of providing domestic hot water energy, as well as space heating, to help balance well filed thermal loading in a cooling dominated application. During the period of August 2012 thru

  15. MiR-218 Mediates tumorigenesis and metastasis: Perspectives and implications

    SciTech Connect

    Lu, Ying-fei; Zhang, Li; Waye, Mary Miu Yee; Fu, Wei-ming; Zhang, Jin-fang

    2015-05-15

    MicroRNAs (miRNAs) are a class of small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. As a highly conserved miRNA across a variety of species, microRNA-218 (miR-218) was found to play pivotal roles in tumorigenesis and progression. A group of evidence has demonstrated that miR-218 acts as a tumor suppressor by targeting many oncogenes related to proliferation, apoptosis and invasion. In this review, we provide a complex overview of miR-218, including its regulatory mechanisms, known functions in cancer and future challenges as a potential therapeutic target in human cancers. - Highlights: • miR-218 is frequently down regulated in multiple cancers. • miR-218 plays pivotal roles in carcinogenesis. • miR-218 mediates proliferation, apoptosis, metastasis, invasion, etc. • miR-218 mediates tumorigenesis and metastasis via multiple pathways.

  16. Enhancing Energy Infrastructure Resiliency and Addressing Vulnerabilities

    Energy.gov [DOE]

    Quadrennial Energy Review Task Force Secretariat and Energy Policy and Systems Analysis Staff, U. S. Department of Energy (DOE) Public Meeting on “Enhancing Resilience in Energy Infrastructure and Addressing Vulnerabilities” On Friday, April 11, 2014, at 10 a.m. in room HVC-215 of the U.S. Capitol, the Department of Energy (DOE), acting as the Secretariat for the Quadrennial Energy Review Task Force, will hold a public meeting to discuss and receive comments on issues related to the Quadrennial Energy Review (QER). The meeting will focus on infrastructure vulnerabilities related to the electricity, natural gas and petroleum transmission, storage and distribution systems (TS&D). The meeting will consist of two facilitated panels of experts on identifying and addressing vulnerabilities within the nation’s energy TS&D infrastructure. Following the panels, an opportunity will be provided for public comment via an open microphone session. The meeting will be livestreamed at energy.gov/live

  17. Global-Address Space Networking (GASNet) Library

    Energy Science and Technology Software Center

    2011-04-06

    GASNet (Global-Address Space Networking) is a language-independent, low-level networking layer that provides network-independent, high-performance communication primitives tailored for implementing parallel global address space SPMD languages such as UPC and Titanium. The interface is primarily intended as a compilation target and for use by runtime library writers (as opposed to end users), and the primary goals are high performance, interface portability, and expressiveness. GASNet is designed specifically to support high-performance, portable implementations of global address spacemore » languages on modern high-end communication networks. The interface provides the flexibility and extensibility required to express a wide variety of communication patterns without sacrificing performance by imposing large computational overheads in the interface. The design of the GASNet interface is partitioned into two layers to maximize porting ease without sacrificing performance: the lower level is a narrow but very general interface called the GASNet core API - the design is basedheavily on Active Messages, and is implemented directly on top of each individual network architecture. The upper level is a wider and more expressive interface called GASNet extended API, which provides high-level operations such as remote memory access and various collective operations. This release implements GASNet over MPI, the Quadrics "elan" API, the Myrinet "GM" API and the "LAPI" interface to the IBM SP switch. A template is provided for adding support for additional network interfaces.« less

  18. DOE Tour of Zero: 5th Street Deep Rehab by Carl Franklin Homes & Green

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Extreme Homes | Department of Energy 5th Street Deep Rehab by Carl Franklin Homes & Green Extreme Homes DOE Tour of Zero: 5th Street Deep Rehab by Carl Franklin Homes & Green Extreme Homes 1 of 12 Carl Franklin Homes renovated this 1,108-square-foot home in Garland, Texas, to the performance criteria of the U.S. Department of Energy Zero Energy Ready Home (ZERH) program. 2 of 12 This home was gutted down to the studs, partially reframed, and completely re-sided as part of an

  19. DOE Tour of Zero: Taylor Street by Greenhill Contracting | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energy Taylor Street by Greenhill Contracting DOE Tour of Zero: Taylor Street by Greenhill Contracting 1 of 12 Greenhill Contracting built this 4,190-square-foot house in Esopus, New York, to the performance criteria of the U.S. Department of Energy Zero Energy Ready Home (ZERH) program, resulting in an estimated energy cost savings of about $4,800 per year compared to minimally code-compliant house without a photovoltaic electric generation system. 2 of 12 The builder took advantage of the

  20. DOE Tour of Zero: 5th Street Deep Rehab by Carl Franklin Homes & Green

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Extreme Homes | Department of Energy 5th Street Deep Rehab by Carl Franklin Homes & Green Extreme Homes DOE Tour of Zero: 5th Street Deep Rehab by Carl Franklin Homes & Green Extreme Homes Addthis 1 of 12 Carl Franklin Homes renovated this 1,108-square-foot home in Garland, Texas, to the performance criteria of the U.S. Department of Energy Zero Energy Ready Home (ZERH) program. 2 of 12 This home was gutted down to the studs, partially reframed, and completely re-sided as part of an

  1. Working with Cities to Light Our Streets Better | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Cities to Light Our Streets Better Working with Cities to Light Our Streets Better January 26, 2015 - 9:18pm Addthis Franklin (Lynn) Orr Franklin (Lynn) Orr Under Secretary for Science and Energy Last week, mayors from around the nation visited Washington, D.C., for the U.S. Conference of Mayors' annual winter meeting. During a White House briefing, I had the chance to meet with 30 mayors who are committed to tackling today's energy and climate challenges. Cities are on the frontlines of

  2. DOE Tour of Zero: Howell Street by TC Legend Homes | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Howell Street by TC Legend Homes DOE Tour of Zero: Howell Street by TC Legend Homes Addthis 1 of 7 TC Legend Homes built this 788-square-foot accessory dwelling unit behind the homeowners' existing house in Seattle, Washington, to the performance criteria of the DOE Energy Zero Energy Ready Home (ZERH) program. 2 of 7 The walls of this house are constructed using 6-inch structurally insulated panels with an insulation value of R-29. The seams of the panels are taped, and the cement board siding

  3. NuMI Low Energy Flux Prediction Release

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    NuMI Low Energy Flux Prediction Release Neutrino Flux Predictions for the NuMI Beam hep-ex/1607.00704 Data Ancillary data files for this result are available on arXiv at http://arxiv.org/src/1607.00704/anc Among the available data files are: pdf file describing format of all the available files root file of all the available fluxes python code to read and process MINERvA's flux predictions Text Files of the flux, uncertainties, and covariance matrix, with units of neutrinos/m^2/POT, in 0.5 GeV

  4. miRNA-205 affects infiltration and metastasis of breast cancer

    SciTech Connect

    Wang, Zhouquan; Department of Tumor, SenGong Hospital of Shaanxi, Xian 710300 ; Liao, Hehe; Deng, Zhiping; Yang, Po; Du, Ning; Zhanng, Yunfeng; Ren, Hong

    2013-11-08

    Highlights: We detected expression of miR-205 in breast cancer cell lines and tissue samples. We suggest miR-205 is downregulated in human breast cancer tissues and MCF7 cells. We suggest the lower expression of miR-205 play a role in breast cancer onset. These data suggest that miR-205 directly targets HER3 in human breast cancer. -- Abstract: Background: An increasing number of studies have shown that miRNAs are commonly deregulated in human malignancies, but little is known about the function of miRNA-205 (miR-205) in human breast cancer. The present study investigated the influence of miR-205 on breast cancer malignancy. Methods: The expression level of miR-205 in the MCF7 breast cancer cell line was determined by quantitative (q)RT-PCR. We then analyzed the expression of miR-205 in breast cancer and paired non-tumor tissues. Finally, the roles of miR-205 in regulating tumor proliferation, apoptosis, migration, and target gene expression were studied by MTT assay, flow cytometry, qRT-PCR, Western blotting and luciferase assay. Results: miR-205 was downregulated in breast cancer cells or tissues compared with normal breast cell lines or non-tumor tissues. Overexpression of miR-205 reduced the growth and colony-formation capacity of MCF7 cells by inducing apoptosis. Overexpression of miR-205 inhibited MCF7 cell migration and invasiveness. By bioinformation analysis, miR-205 was predicted to bind to the 3? untranslated regions of human epidermal growth factor receptor (HER)3 mRNA, and upregulation of miR-205 reduced HER3 protein expression. Conclusion: miR-205 is a tumor suppressor in human breast cancer by post-transcriptional inhibition of HER3 expression.

  5. Ground Motion Studies at NuMI

    SciTech Connect

    Mayda M. Velasco; Michal Szleper

    2012-02-20

    Ground motion can cause significant deterioration in the luminosity of a linear collider. Vibration of numerous focusing magnets causes continuous misalignments, which makes the beam emittance grow. For this reason, understanding the seismic vibration of all potential LC sites is essential and related efforts in many sites are ongoing. In this document we summarize the results from the studies specific to Fermilab grounds as requested by the LC project leader at FNAL, Shekhar Mishra in FY04-FY06. The Northwestern group focused on how the ground motion effects vary with depth. Knowledge of depth dependence of the seismic activity is needed in order to decide how deep the LC tunnel should be at sites like Fermilab. The measurements were made in the NuMI tunnel, see Figure 1. We take advantage of the fact that from the beginning to the end of the tunnel there is a height difference of about 350 ft and that there are about five different types of dolomite layers. The support received allowed to pay for three months of salary of Michal Szleper. During this period he worked a 100% of his time in this project. That include one week of preparation: 2.5 months of data taking and data analysis during the full period of the project in order to guarantee that we were recording high quality data. We extended our previous work and made more systematic measurements, which included detailed studies on stability of the vibration amplitudes at different depths over long periods of time. As a consequence, a better control and more efficient averaging out of the daytime variation effects were possible, and a better study of other time dependences before the actual depth dependence was obtained. Those initial measurements were made at the surface and are summarized in Figure 2. All measurements are made with equipment that we already had (two broadband seismometers KS200 from GEOTECH and DL-24 portable data recorder). The offline data analysis took advantage of the full Fourier spectra

  6. Framework for Address Cooperative Extended Transactions

    Energy Science and Technology Software Center

    1997-12-01

    The Framework for Addressing Cooperative Extended Transactions (FACET) is an object-oriented software framework for building models of complex, cooperative behaviors of agents. it can be used to implement simulation models of societal processes such as the complex interplay of participating individuals and organizations engaged in multiple concurrent transactions in pursuit of their various goals. These transactions can be patterned on, for example, clinical guidelines and procedures, business practices, government and corporate policies, etc. FACET canmore » also address other complex behaviors such as biological life cycles or manufacturing processes. FACET includes generic software objects representing the fundamental classes of agent -- Person and Organization - with mechanisms for resource management, including resolution of conflicting requests for participation and/or use of the agent's resources. The FACET infrastructure supports stochastic behavioral elements and coping mechanisms by which specified special conditions and events can cause an active cooperative process to be preempted, diverting the participants onto appropriate alternative behavioral pathways.« less

  7. Demonstration Assessment of Light-Emitting Diode (LED) Street Lighting Host Site: Lija Loop, Portland, Oregon

    SciTech Connect

    Kinzey, Bruce R.; Myer, Michael

    2009-11-01

    This report describes the process and results of a demonstration of solid-state lighting (SSL) technology in a residential street lighting application, under the U.S. Department of Energy GATEWAY Solid-State Lighting Technology Demonstration Program. In this project, eight 100W (nominal) high-pressure sodium cobra head fixtures were replaced with a like number of LED street light luminaires manufactured by Leotek, Inc. The Leotek product achieved an estimated payback in the Lija Loop installation of about 20 years for replacement scenarios and a much shorter 7.6 years for new installations. Much of the associated energy savings (55%) supporting these payback periods, however, were achieved by reducing average horizontal photopic illuminance a similar amount (53%). Examined from a different perspective, the measured performance suggests that the Leotek product is at approximate parity with the HPS cobra head in terms of average delivered photopic illumination for a given power consumption. HPS comprises the second most efficacious street lighting technology available, exceeded only by low pressure sodium (LPS). LPS technology is not considered suitable for most street lighting applications due to its monochromatic spectral output and poor color rendering ability; therefore, this LED product is performing at an efficiency level comparable to its primary competition in this application.

  8. DOE - Office of Legacy Management -- Mitts-Merrill Co - MI 14

    Office of Legacy Management (LM)

    1993 MI.14-2 Site Operations: Reduced thorium metal chunks into particle sized pieces ... Primary Radioactive Materials Handled: Thorium MI.14-1 Radiological Survey(s): Yes - ...

  9. DOE - Office of Legacy Management -- Mitts-Merrel Co - MI 14

    Office of Legacy Management (LM)

    1993 MI.14-2 Site Operations: Reduced thorium metal chunks into particle sized pieces ... Primary Radioactive Materials Handled: Thorium MI.14-1 Radiological Survey(s): Yes - ...

  10. MiR-125a TNF receptor-associated factor 6 to inhibit osteoclastogenesis

    SciTech Connect

    Guo, Li-Juan; Liao, Lan; Yang, Li; Li, Yu; Jiang, Tie-Jian

    2014-02-15

    MicroRNAs (miRNAs) play important roles in osteoclastogenesis and bone resorption. In the present study, we found that miR-125a was dramatically down-regulated during macrophage colony stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ligand (RANKL) induced osteoclastogenesis of circulating CD14+ peripheral blood mononuclear cells (PBMCs). Overexpression of miR-125a in CD14+ PBMCs inhibited osteoclastogenesis, while inhibition of miR-125a promoted osteoclastogenesis. TNF receptor-associated factor 6 (TRAF6), a transduction factor for RANKL/RANK/NFATc1 signal, was confirmed to be a target of miR-125a. EMSA and ChIP assays confirmed that NFATc1 bound to the promoter of the miR-125a. Overexpression of NFATc1 inhibited miR-125a transcription, and block of NFATc1 expression attenuated RANKL-regulated miR-125a transcription. Here, we reported that miR-125a played a biological function in osteoclastogenesis through a novel TRAF6/ NFATc1/miR-125a regulatory feedback loop. It suggests that regulation of miR-125a expression may be a potential strategy for ameliorating metabolic disease. - Highlights: • MiR-125a was significantly down-regulated in osteoclastogenesis of CD14+ PBMCs. • MiR-125a inhibited osteoclast differentiation by targeting TRAF6. • NFATc1 inhibited miR-125a transciption by binding to the promoter of miR-125a. • TRAF6/NFATc1 and miR-125a form a regulatory feedback loop in osteoclastogenesis.

  11. Port Huron, MI Liquefied Natural Gas Exports (Million Cubic Feet...

    Energy Information Administration (EIA) (indexed site)

    (Million Cubic Feet) Port Huron, MI Liquefied Natural Gas Exports (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2013 1 2014 1 1 1 1 2 1 1 1 1 1 2015 1 1...

  12. Neutron scattering study of spin ordering and stripe pinning in superconducting <mi>La>1.93<mi>Sr>0.07<mi>CuO>4

    SciTech Connect

    Jacobsen, H.; Zaliznyak, I. A.; Savici, A. T.; Winn, B. L.; Chang, S.; Hücker, M.; Gu, G. D.; Tranquada, J. M.

    2015-11-20

    The relationships among charge order, spin fluctuations, and superconductivity in underdoped cuprates remain controversial. We use neutron scattering techniques to study these phenomena in <mi>La>1.93<mi>Sr>0.07<mi>CuO>4 a superconductor with a transition temperature of Tc = 20 K. At T<< Tc, we find incommensurate spin fluctuations with a quasielastic energy spectrum and no sign of a gap within the energy range from 0.2 to 15 meV. A weak elastic magnetic component grows below ~ 10 K, consistent with results from local probes. Regarding the atomic lattice, we have discovered unexpectedly strong fluctuations of the CuO6 octahedra about Cu-O bonds, which are associated with inequivalent O sites within the CuO2 planes. Moreover, we observed a weak elastic (3 30) superlattice peak that implies a reduced lattice symmetry. The presence of inequivalent O sites rationalizes various pieces of evidence for charge stripe order in underdoped La2-xSrxCuO4. The coexistence of superconductivity with quasi-static spin-stripe order suggests the presence of intertwined orders; however, the rotation of the stripe orientation away from the Cu-O bonds might be connected with evidence for a finite gap at the nodal points of the superconducting gap function.

  13. Superfund Record of Decision (EPA Region 2): Hooker-102nd Street Landfill, Niagara Falls, NY. (First remedial action), September 1990. Final report

    SciTech Connect

    Not Available

    1990-09-26

    The 22-acre Hooker-102nd Street site is a former industrial landfill in the city of Niagara Falls, Niagara County, New York. The site is adjacent to, and partially within the Niagara River's 100-year floodplain. These studies and the Remedial Investigation (RI) initiated in 1984, identified contamination in ground water, onsite and offsite soil, rivershore sediment, and within a storm sewer. Additionally, the presence of a leachate plume of non-aqueous phase liquids (NAPLs) was discovered emanating from the landfill area. The Record of Decision (ROD) is the final remedy which addresses all of the contaminated media. The primary contaminants of concern affecting the soil, sediment, and ground water are VOCs including benzene, TCE, and toluene; other organics including PCBs and phenols; and metals including arsenic.

  14. MiR-145 functions as a tumor suppressor targeting NUAK1 in human intrahepatic cholangiocarcinoma

    SciTech Connect

    Xiong, Xinkui; Sun, Daoyi; Chai, Hao; Shan, Wengang; Yu, Yue; Pu, Liyong; Cheng, Feng

    2015-09-18

    The dysregulation of micro (mi)RNAs is associated with cancer development. The miRNA miR-145 is downregulated in intrahepatic cholangiocarcinoma (ICC); however, its precise role in tumor progression has not yet been elucidated. Novel (nua) kinase family (NUAK)1 functions as an oncogene in various cancers and is a putative target of miR-145 regulation. In this study, we investigated the regulation of NUAK1 by miR-145 in ICC. We found that miR-145 level was significantly decreased in ICC tissue and cell lines, which corresponded with an increase in NUAK1 expression. NUAK1 was found to be a direct target of miR-145 regulation. The overexpression of miR-145 in ICC cell lines inhibited proliferation, growth, and invasion by suppressing NUAK1 expression, which was associated with a decrease in Akt signaling and matrix metalloproteinase protein expression. Similar results were observed by inhibiting NUAK1 expression. These results demonstrate that miR-145 can prevent ICC progression by targeting NUAK1 and its downstream effectors, and can therefore be useful for clinical diagnosis and targeted therapy of ICC. - Highlights: • MiR-145 suppresses ICC proliferation and invasion abilities. • We demonstrated that miR-145 directly targets NUAK1 in ICC. • MiR-145 expression in ICC was associated with Akt signaling and MMPs expression.

  15. Radiosensitizing Effects of Ectopic miR-101 on Non-Small-Cell Lung Cancer Cells Depend on the Endogenous miR-101 Level

    SciTech Connect

    Chen, Susie; Wang Hongyan; Ng, Wooi Loon; Curran, Walter J.; Wang Ya

    2011-12-01

    Purpose: Previously, we showed that ectopic miR-101 could sensitize human tumor cells to radiation by targeting ATM and DNA-PK catalytic subunit (DNA-PKcs) to inhibit DNA repair, as the endogenous miR-101 levels are low in tumors in general. However, the heterogeneity of human cancers may result in an exception. The purpose of this study was to test the hypothesis that a few tumor cell lines with a high level of endogenous miR-101 would prove less response to ectopic miR-101. Methods and Materials: Fourteeen non-small-cell lung cancer (NSCLC) cell lines and one immortalized non-malignant lung epithelial cell line (NL20) were used for comparing endogenous miR-101 levels by real-time reverse transcription-polymerase chain reaction. Based on the different miR-101 levels, four cell lines with different miR-101 levels were chosen for transfection with a green fluorescent protein-lentiviral plasmid encoding miR-101. The target protein levels were measured by using Western blotting. The radiosensitizing effects of ectopic miR-101 on these NSCLC cell lines were determined by a clonogenic assay and xenograft mouse model. Results: The endogenous miR-101 level was similar or lower in 13 NSCLC cell lines but was 11-fold higher in one cell line (H157) than in NL20 cells. Although ectopic miR-101 efficiently decreased the ATM and DNA-PKcs levels and increased the radiosensitization level in H1299, H1975, and A549 cells, it did not change the levels of the miR-101 targets or radiosensitivity in H157 cells. Similar results were observed in xenograft mice. Conclusions: A small number of NSCLC cell lines could have a high level of endogenous miR-101. The ectopic miR-101 was able to radiosensitize most NSCLC cells, except for the NSCLC cell lines that had a much higher endogenous miR-101 level. These results suggest that when we choose one miRNA as a therapeutic tool, the endogenous level of the miRNA in each tumor should be considered.

  16. Opportunities for Building America Research to Address Energy...

    Energy Saver

    Opportunities for Building America Research to Address Energy Upgrade Technical Challenges: HVAC, Envelope and IAQ (301) Opportunities for Building America Research to Address...

  17. Keck Institute for Space Studies "Addressing the MARS ISRU Challenge...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Keck Institute for Space Studies "Addressing the MARS ISRU Challenge" Workshop Keck Institute for Space Studies "Addressing the MARS ISRU Challenge" Workshop Tue, Jun 28, 2016 ...

  18. DOE Convenes Multi-stakeholder Process to Address Privacy for...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Convenes Multi-stakeholder Process to Address Privacy for Data Enabled by Smart Grid Technologies DOE Convenes Multi-stakeholder Process to Address Privacy for Data Enabled by ...

  19. Dairyland Power Cooperative Comments on Smart Grid RFI: Addressing...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Comments on Smart Grid RFI: Addressing Policy and Logistical Challenges Dairyland Power Cooperative Comments on Smart Grid RFI: Addressing Policy and Logistical Challenges ...

  20. Addressing Uncertainties in Design Inputs: A Case Study of Probabilist...

    Office of Environmental Management (EM)

    Addressing Uncertainties in Design Inputs: A Case Study of Probabilistic Settlement Evaluations for Soft Zone Collapse at SWPF Addressing Uncertainties in Design Inputs: A Case ...

  1. Addressable morphology control of silica structures by manipulating...

    Office of Scientific and Technical Information (OSTI)

    Addressable morphology control of silica structures by manipulating the reagent addition time Citation Details In-Document Search Title: Addressable morphology control of silica ...

  2. Financing Innovation to Address Global Climate Change | Department...

    Office of Environmental Management (EM)

    Financing Innovation to Address Global Climate Change Financing Innovation to Address Global Climate Change DOE-LPOReportFinancing-Innovation-Climate-Change.pdf (1.97 MB) More ...

  3. ASHRAE draft regarding Smart Grid RFI: Addressing Policy and...

    Energy Saver

    ASHRAE draft regarding Smart Grid RFI: Addressing Policy and Logistical Challenges ASHRAE draft regarding Smart Grid RFI: Addressing Policy and Logistical Challenges The American ...

  4. Natural Gas Industry Comments on Smart Grid RFI: Addressing Policy...

    Office of Environmental Management (EM)

    Natural Gas Industry Comments on Smart Grid RFI: Addressing Policy and Logistical Challenges to Smart Grid Natural Gas Industry Comments on Smart Grid RFI: Addressing Policy and ...

  5. Department of Energy Releases Strategic Plan to Address Energy...

    Energy Saver

    Strategic Plan to Address Energy Challenges Department of Energy Releases Strategic Plan to Address Energy Challenges October 2, 2006 - 9:01am Addthis WASHINGTON, DC - Secretary of ...

  6. Bush Administration Plays Leading Role in Studying and Addressing...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Bush Administration Plays Leading Role in Studying and Addressing Global Climate Change Bush Administration Plays Leading Role in Studying and Addressing Global Climate Change...

  7. Steffes Corporation Smart Grid RFI: Addressing Policy and Logistical...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Steffes Corporation Smart Grid RFI: Addressing Policy and Logistical Challenges Steffes Corporation Smart Grid RFI: Addressing Policy and Logistical Challenges Steffes Corporation ...

  8. Pepco Holdings, Inc. Smart Grid RFI: Addressing Policy and Logistical...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Holdings, Inc. Smart Grid RFI: Addressing Policy and Logistical Challenges Pepco Holdings, Inc. Smart Grid RFI: Addressing Policy and Logistical Challenges Pepco Holdings, Inc. ...

  9. Policy Agenda for Addressing Climate Change in Bangladesh: Copenhagen...

    OpenEI (Open Energy Information) [EERE & EIA]

    Agenda for Addressing Climate Change in Bangladesh: Copenhagen and Beyond Jump to: navigation, search Name Policy Agenda for Addressing Climate Change in Bangladesh: Copenhagen and...

  10. Indonesia National Action Plan Addressing Climate Change | Open...

    OpenEI (Open Energy Information) [EERE & EIA]

    National Action Plan Addressing Climate Change Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Indonesia National Action Plan Addressing Climate Change AgencyCompany...

  11. Addressing Policy and Logistical Challenges to Smart Grid Implementati...

    Office of Environmental Management (EM)

    Addressing Policy and Logistical Challenges to Smart Grid Implementation: Comments by the ... "Addressing Policy and Logistical Challenges to Smart Grid Implementation" See 75 Fed. ...

  12. Addressing Policy and Logistical Challenges to smart grid Implementati...

    Office of Environmental Management (EM)

    Addressing Policy and Logistical Challenges to smart grid Implementation: eMeter Response ... Addressing Policy and Logistical Challenges to smart grid Implementation: Response to ...

  13. NERSC Implements Organizational Changes to Better Address Evolving...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Organizational Changes to Better Address Evolving Data Environment NERSC Implements Organizational Changes to Better Address Evolving Data Environment February 23, 2015 Contact: ...

  14. Energy-Intensive Processes Portfolio: Addressing Key Energy Challenges...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energy-Intensive Processes Portfolio: Addressing Key Energy Challenges Across U.S. Industry Energy-Intensive Processes Portfolio: Addressing Key Energy Challenges Across U.S. ...

  15. Strategies to Address Split Incentives in Multifamily Buildings...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    to Address Split Incentives in Multifamily Buildings Strategies to Address Split Incentives in Multifamily Buildings Better Buildings Neighborhood Program Multifamily Low-Income ...

  16. Energy Department Addresses Largest Gathering of Geothermal Energy...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Addresses Largest Gathering of Geothermal Energy Stakeholders Energy Department Addresses Largest Gathering of Geothermal Energy Stakeholders October 4, 2012 - 1:00pm Addthis Photo ...

  17. Smart Grid RFI: Addressing Policy and Logistical Challenges....

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Smart Grid RFI: Addressing Policy and Logistical Challenges. Comments of the Alliance to Save Energy. Smart Grid RFI: Addressing Policy and Logistical Challenges. Comments of the...

  18. Protocol for Addressing Induced Seismicity Associated with Enhanced...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Protocol for Addressing Induced Seismicity Associated with Enhanced Geothermal Systems (EGS) Protocol for Addressing Induced Seismicity Associated with Enhanced Geothermal Systems...

  19. Final Report on Internet Addressable Lightswitch

    SciTech Connect

    Rubinstein, Francis; Pettler, Peter

    2001-08-27

    This report describes the work performed to develop and test a new switching system and communications network that is useful for economically switching lighting circuits in existing commercial buildings. The first section of the report provides the general background of the IBECS (Integrated Building Environmental Communications System) research and development work as well as the context for the development of the new switching system. The research and development effort that went into producing the first proof-of-concept (the IBECS Addressable Power Switch or APS) and the physical prototype of that concept is detailed in the second section. In the third section of the report, we detail the refined Powerline Carrier Based IBECS Title 24 Wall Switch system that evolved from the APS prototype. The refined system provided a path for installing IBECS switching technology in existing buildings that may not be already wired for light level switching control. The final section of the report describes the performance of the IBECS Title 24 Switch system as applied to a small demonstration in two offices at LBNL's Building 90. We learned that the new Powerline Carrier control systems (A-10 technology) that have evolved from the early X-10 systems have solved most of the noise problems that dogged the successful application of X-10 technologies in commercial buildings. We found that the new A-10 powerline carrier control technology can be reliable and effective for switching lighting circuits even in electrically noisy office environments like LBNL. Thus we successfully completed the task objectives by designing, building and demonstrating a new switching system that can provide multiple levels of light which can be triggered either from specially designed wall switches or from a digital communications network. By applying commercially available powerline carrier based technologies that communicate over the in-place lighting wiring system, this type of control can be

  20. Executive summary of major NuMI lessons learned: a review of relevant meetings of Fermilab's DUSEL Beamline Working Group

    SciTech Connect

    Andrews, Mike; Appel, Jeffrey A.; Bogert, Dixon; Childress, Sam; Cossairt, Don; Griffing, William; Grossman, Nancy; Harding, David; Hylen, Jim; Kuchler, Vic; Laughton, Chris; /Fermilab /Argonne /Brookhaven /LBL, Berkeley

    2009-05-01

    We have gained tremendous experience with the NuMI Project on what was a new level of neutrino beams from a high power proton source. We expect to build on that experience for any new long baseline neutrino beam. In particular, we have learned about some things which have worked well and/or where the experience is fairly directly applicable to the next project (e.g., similar civil construction issues including: tunneling, service buildings, outfitting, and potential claims/legal issues). Some things might be done very differently (e.g., decay pipe, windows, target, beam dump, and precision of power supply control/monitoring). The NuMI experience does lead to identification of critical items for any future such project, and what issues it will be important to address. The DUSEL Beamline Working Group established at Fermilab has been meeting weekly to collect and discuss information from that NuMI experience. This document attempts to assemble much of that information in one place. In this Executive Summary, we group relevant discussion of some of the major issues and lessons learned under seven categories: (1) Differences Between the NuMI Project and Any Next Project; (2) The Process of Starting Up the Project; (3) Decision and Review Processes; (4) ES&H: Environment, Safety, and Health; (5) Local Community Buy-In; (6) Transition from Project Status to Operation; and (7) Some Lessons on Technical Elements. We concentrate here on internal project management issues, including technical areas that require special attention. We cannot ignore, however, two major external management problems that plagued the NuMI project. The first problem was the top-down imposition of an unrealistic combination of scope, cost, and schedule. This situation was partially corrected by a rebaselining. However, the full, desirable scope was never achievable. The second problem was a crippling shortage of resources. Critical early design work could not be done in a timely fashion, leading to

  1. PPARγ inhibits ovarian cancer cells proliferation through upregulation of miR-125b

    SciTech Connect

    Luo, Shuang; Wang, Jidong; Ma, Ying; Yao, Zhenwei; Pan, Hongjuan

    2015-06-26

    miR-125b has essential roles in coordinating tumor proliferation, angiogenesis, invasiveness, metastasis and chemotherapy recurrence. In ovarian cancer miR-125b has been shown to be downregulated and acts as a tumor suppressor by targeting proto-oncogene BCL3. PPARγ, a multiple functional transcription factor, has been reported to have anti-tumor effects through inhibition of proliferation and induction of differentiation and apoptosis by targeting the tumor related genes. However, it is unclear whether miR-125b is regulated by PPARγ in ovarian cancer. In this study, we demonstrated that the miR-125b downregulated in ovarian cancer tissues and cell lines. Ligands-activated PPARγ suppressed proliferation of ovarian cancer cells and this PPARγ-induced growth inhibition is mediated by the upregulation of miR-125b. PPARγ promoted the expression of miR-125b by directly binding to the responsive element in miR-125b gene promoter region. Thus, our results suggest that PPARγ can induce growth suppression of ovarian cancer by upregulating miR-125b which inhibition of proto-oncogene BCL3. These findings will extend our understanding of the function of PPARγ in tumorigenesis and miR-125b may be a therapeutic intervention of ovarian cancer. - Highlights: • miR-125b is down-regulated in ovarian cancer tissues and cells. • PPARγ upregulates miR-125b and downregulates its target gene BCL3 expression. • Silence of miR-125b attenuates PPARγ-mediated growth suppression of ovarian cancer cells. • PPARγ promotes the transcription of miR-125b via binding to PPARE in miR-125b gene promoter region.

  2. Pecan Street Smart Grid Extension Service at the University of Texas

    SciTech Connect

    McCracken, Brewster

    2014-02-11

    Through funding from the Department of Energy’s Electricity Delivery and Reliability Office, Pecan Street Inc., in partnership with Austin Energy and Oncor, developed and tested third- party data access platforms and services for Green Button offerings and for other home energy use data providers. As more utilities seek to offer Green Button-compliant data to their customers, the question continually arises of how this data can be used to help customers better manage their energy use.

  3. The Municipal Solid-State Street Lighting Consortium Public Outdoor Lighting Inventory: Phase I: Survey Results

    SciTech Connect

    Kinzey, Bruce R.; Smalley, Edward; Haefer, R.

    2014-09-30

    This document presents the results of a voluntary web-based inventory survey of public street and area lighting across the U.S. undertaken during the latter half of 2013.This survey attempts to access information about the national inventory in a “bottoms-up” manner, going directly to owners and operators. Adding to previous “top down” estimates, it is intended to improve understanding of the role of public outdoor lighting in national energy use.

  4. Dr. Richard Meserve Covington & Burling LLP 850 Tenth Street, NW

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    3, 2016 Dr. Richard Meserve Covington & Burling LLP 850 Tenth Street, NW Washington, D.C. 20001-4956 Dr. Joy Rempe 360 Stillwater Idaho Falls, ID 83404 Dear Dr. Meserve and Dr. Rempe: I request that the Nuclear Energy Advisory Committee's (NEAC's) Nuclear Reactor Technology Subcommittee organize a review of the Department of Energy Office of Nuclear Energy (DOE-NE) draft Vision and Strategy for the Development and Deployment of Advanced Reactors. Given the number of nuclear plant retirements

  5. Keynote Address: Billy Parish of Mosaic | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Billy Parish of Mosaic Keynote Address: Billy Parish of Mosaic May 20, 2014 3:00PM to 3:30PM PDT Pacific Ballroom Billy Parish, President and Founder of Mosaic, will address Summit attendees

  6. ASER Web Addresses and Points of Contact at DOE Sites

    Energy.gov [DOE] (indexed site)

    ASER Web Addresses and Points of Contact at DOE Sites March 29, 2013 Site and Web Address ASER Contact Name Phone E-mail Ames Laboratory http:www.ameslab.govoperationsesha...

  7. Microsoft Word - craft-change-address-form.docx

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    CHANGE OF NAME, ADDRESS, TELEPHONE and EMERGENCY CONTACT TO: LABOR RELATIONS DATE: ________________________ _______________________ _________________________ Z# SOCIAL SECURITY# _______________________ _________________________ _____________________________ FIRST NAME MIDDLE NAME LAST NAME NEW INFORMATION (WHERE APPLICABLE) NAME CHANGE _______________________ _________________________ _____________________________ FIRST NAME MIDDLE NAME LAST NAME ADDRESS CHANGE _______________________

  8. Technology Plan to Address the EM Mercury Challenge

    Office of Energy Efficiency and Renewable Energy (EERE)

    EM’s Technology Plan to Address the EM Mercury Challenge addresses mercury contamination, and advocates for research and technology development to resolve key technical uncertainties with the pollutant in environmental remediation, facility deactivation and decommissioning, and tank waste processing.

  9. Southern Company: DOE Smart Grid RFI Addressing Policy and Logistical

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Challenges | Department of Energy Southern Company: DOE Smart Grid RFI Addressing Policy and Logistical Challenges Southern Company: DOE Smart Grid RFI Addressing Policy and Logistical Challenges Southern Company: DOE Smart Grid RFI Addressing Policy and Logistical Challenges. Southern recognizes that many policy and logistical concerns must be addressed for the promises of smart grid technologies and applications to be fully realized in ways that are beneficial, secure, and cost-effective

  10. Pepco Holdings, Inc. Smart Grid RFI: Addressing Policy and Logistical

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Challenges | Department of Energy Holdings, Inc. Smart Grid RFI: Addressing Policy and Logistical Challenges Pepco Holdings, Inc. Smart Grid RFI: Addressing Policy and Logistical Challenges Pepco Holdings, Inc. Smart Grid RFI: Addressing Policy and Logistical Challenges. Pepco Holdings, Inc. (PHI) is pleased to respond to the US Department of Energy (DOE) request for information regarding addressing policy and logistical challenges to smart grid implementation. This follows on the heels of

  11. Progress Energy draft regarding Smart Grid RFI: Addressing Policy and

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Logistical Challenges | Department of Energy Progress Energy draft regarding Smart Grid RFI: Addressing Policy and Logistical Challenges Progress Energy draft regarding Smart Grid RFI: Addressing Policy and Logistical Challenges Progress Energy draft regarding Smart Grid RFI: Addressing Policy and Logistical Challenges Progress Energy draft regarding Smart Grid RFI: Addressing Policy and Logistical Challenges (549.44 KB) More Documents & Publications Comments of DRSG to DOE Smart Grid

  12. Individually addressable cathodes with integrated focusing stack or detectors

    DOEpatents

    Thomas, Clarence E.; Baylor, Larry R.; Voelkl, Edgar; Simpson, Michael L.; Paulus, Michael J.; Lowndes, Douglas; Whealton, John; Whitson, John C.; Wilgen, John B.

    2005-07-12

    Systems and method are described for addressable field emission array (AFEA) chips. A plurality of individually addressable cathodes are integrated with an electrostatic focusing stack and/or a plurality of detectors on the addressable field emission array. The systems and methods provide advantages including the avoidance of space-charge blow-up.

  13. Genome-Wide Analysis of miRNA targets in Brachypodium and Biomass Energy Crops

    SciTech Connect

    Green, Pamela J.

    2015-08-11

    MicroRNAs (miRNAs) contribute to the control of numerous biological processes through the regulation of specific target mRNAs. Although the identities of these targets are essential to elucidate miRNA function, the targets are much more difficult to identify than the small RNAs themselves. Before this work, we pioneered the genome-wide identification of the targets of Arabidopsis miRNAs using an approach called PARE (German et al., Nature Biotech. 2008; Nature Protocols, 2009). Under this project, we applied PARE to Brachypodium distachyon (Brachypodium), a model plant in the Poaceae family, which includes the major food grain and bioenergy crops. Through in-depth global analysis and examination of specific examples, this research greatly expanded our knowledge of miRNAs and target RNAs of Brachypodium. New regulation in response to environmental stress or tissue type was found, and many new miRNAs were discovered. More than 260 targets of new and known miRNAs with PARE sequences at the precise sites of miRNA-guided cleavage were identified and characterized. Combining PARE data with the small RNA data also identified the miRNAs responsible for initiating approximately 500 phased loci, including one of the novel miRNAs. PARE analysis also revealed that differentially expressed miRNAs in the same family guide specific target RNA cleavage in a correspondingly tissue-preferential manner. The project included generation of small RNA and PARE resources for bioenergy crops, to facilitate ongoing discovery of conserved miRNA-target RNA regulation. By associating specific miRNA-target RNA pairs with known physiological functions, the research provides insights about gene regulation in different tissues and in response to environmental stress. This, and release of new PARE and small RNA data sets should contribute basic knowledge to enhance breeding and may suggest new strategies for improvement of biomass energy crops.

  14. DLEU2, frequently deleted in malignancy, functions as a critical host gene of the cell cycle inhibitory microRNAs miR-15a and miR-16-1

    SciTech Connect

    Lerner, Mikael; Harada, Masako; Loven, Jakob; Castro, Juan; Davis, Zadie; Oscier, David; Henriksson, Marie; Sangfelt, Olle; Grander, Dan; Corcoran, Martin M.

    2009-10-15

    The microRNAs miR-15a and miR-16-1 are downregulated in multiple tumor types and are frequently deleted in chronic lymphocytic leukemia (CLL), myeloma and mantle cell lymphoma. Despite their abundance in most cells the transcriptional regulation of miR-15a/16-1 remains unclear. Here we demonstrate that the putative tumor suppressor DLEU2 acts as a host gene of these microRNAs. Mature miR-15a/miR-16-1 are produced in a Drosha-dependent process from DLEU2 and binding of the Myc oncoprotein to two alterative DLEU2 promoters represses both the host gene transcript and levels of mature miR-15a/miR-16-1. In line with a functional role for DLEU2 in the expression of the microRNAs, the miR-15a/miR-16-1 locus is retained in four CLL cases that delete both promoters of this gene and expression analysis indicates that this leads to functional loss of mature miR-15a/16-1. We additionally show that DLEU2 negatively regulates the G1 Cyclins E1 and D1 through miR-15a/miR-16-1 and provide evidence that these oncoproteins are subject to miR-15a/miR-16-1-mediated repression under normal conditions. We also demonstrate that DLEU2 overexpression blocks cellular proliferation and inhibits the colony-forming ability of tumor cell lines in a miR-15a/miR-16-1-dependent way. Together the data illuminate how inactivation of DLEU2 promotes cell proliferation and tumor progression through functional loss of miR-15a/miR-16-1.

  15. Microfluidic Molecular Assay Platform for the Detection of miRNAs...

    Office of Scientific and Technical Information (OSTI)

    Article: Microfluidic Molecular Assay Platform for the Detection of miRNAs, mRNAs, Proteins, and Post-translational Modifications at Single-cell Resolution. Citation Details...

  16. DOE - Office of Legacy Management -- Baker-Perkins Co - MI 13

    Office of Legacy Management (LM)

    Site Disposition: Eliminated - Potential for contamination remote based on limited scope of activities at the site MI.13-3 Radioactive Materials Handled: Yes Primary ...

  17. miR-4295 promotes cell proliferation and invasion in anaplastic thyroid carcinoma via CDKN1A

    SciTech Connect

    Shao, Mingchen; Geng, Yiwei; Lu, Peng; Xi, Ying; Wei, Sidong; Wang, Liuxing; Fan, Qingxia; Ma, Wang

    2015-09-04

    MicroRNAs (miRNAs) play important roles in the pathogenesis of many types of cancers by negatively regulating gene expression at posttranscriptional level. However, the role of microRNAs in anaplastic thyroid carcinoma (ATC), has remained elusive. Here, we identified that miR-4295 promotes ATC cell proliferation by negatively regulates its target gene CDKN1A. In ATC cell lines, CCK-8 proliferation assay indicated that the cell proliferation was promoted by miR-4295, while miR-4295 inhibitor significantly inhibited the cell proliferation. Transwell assay showed that miR-4295 mimics significantly promoted the migration and invasion of ATC cells, whereas miR-4295 inhibitors significantly reduced cell migration and invasion. luciferase assays confirmed that miR-4295 directly bound to the 3'untranslated region of CDKN1A, and western blotting showed that miR-4295 suppressed the expression of CDKN1A at the protein levels. This study indicated that miR-4295 negatively regulates CDKN1A and promotes proliferation and invasion of ATC cell lines. Thus, miR-4295 may represent a potential therapeutic target for ATC intervention. - Highlights: • miR-4295 mimics promote the proliferation and invasion of ATC cells. • miR-4295 inhibitors inhibit the proliferation and invasion of ATC cells. • miR-4295 targets 3′UTR of CDKN1A in ATC cells. • miR-4295 negatively regulates CDKN1A in ATC cells.

  18. Groundwater protection for the NuMI project

    SciTech Connect

    Wehmann, A.; Smart, W.; Menary, S.; Hylen, J.; Childress, S.

    1997-10-01

    The physics requirements for the long base line neutrino oscillation experiment MINOS dictate that the NuMI beamline be located in the aquifer at Fermilab. A methodology is described for calculating the level of radioactivation of groundwater caused by operation of this beamline. A conceptual shielding design for the 750 meter long decay pipe is investigated which would reduce radioactivation of the groundwater to below government standards. More economical shielding designs to meet these requirements are being explored. Also, information on local geology, hydrogeology, government standards, and a glossary have been included.

  19. Radiological survey results at 14 Cliff Street, Beverly, Massachusetts (VB011)

    SciTech Connect

    Foley, R.D.; Carrier, R.F.

    1992-08-01

    At the request of the US Department of Energy (DOE), a team from Oak Ridge National Laboratory conducted a radiological survey at 14 Cliff Street, Beverly, Massachusetts. The survey was performed in May 1991. The purpose of the survey was to determine if uranium dust from work performed under government contract at the former Ventron facility had migrated off-site to neighboring areas. The survey included a surface gamma scan and the collection of soil samples for radionuclide analyses. Results of the survey demonstrated no radionuclide concentrations or radiation measurements in excess of the DOE Formerly Utilized Sites Remedial Action Program guidelines.

  20. Soliton Instabilities and Vortex Street Formation in a Polariton Quantum Fluid

    SciTech Connect

    Grosso, G.; Nardin, G.; Morier-Genoud, F.; Leger, Y.; Deveaud-Pledran, B.

    2011-12-09

    Exciton polaritons have been shown to be an optimal system in order to investigate the properties of bosonic quantum fluids. We report here on the observation of dark solitons in the wake of engineered circular obstacles and their decay into streets of quantized vortices. Our experiments provide a time-resolved access to the polariton phase and density, which allows for a quantitative study of instabilities of freely evolving polaritons. The decay of solitons is quantified and identified as an effect of disorder-induced transverse perturbations in the dissipative polariton gas.

  1. Superfund Record of Decision (Region 2): Love Canal/93rd Street, New York (third remedial action), September 1988

    SciTech Connect

    Not Available

    1988-09-26

    The Love Canal/93rd Street School site consists of approximately 19 acres and includes a school and an adjacent vacant lot. The site is located in Niagara Falls, New York, less than one mile northwest of Love Canal and is within the Love Canal Emergency Declaration Area. Hooker Chemicals and Plastics Corporation disposed of over 21,000 tons of various chemicals at the Love Canal site from 1942 to 1953, when the site was deeded over to the City of Niagara Falls Board of Education. Sampling has revealed that approximately 6,000 cu yds of soil are contaminated. During the 1950s, home construction accelerated in the area. Specifically, in 1950, the 93rd Street School was built, and in 1954, the 99th Street School was built adjacent to the middle portion of the Canal. Prior to construction of the 93rd Street School, a drainage swale crossed the site. Between 1938 and 1951, the swale was partially filled with soil and rock debris, followed by sand and fly ash materials. In 1980, the 93rd Street School was closed due to public health concerns related to the potentially contaminated fill material. The primary contaminants of concern affecting soil are VOCs, including toluene and xylenes, other organics including dioxins, PAHs and pesticides, and metals including arsenic and lead.

  2. REC Silicon formerly ASiMI | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    ,"searchmarkers":"","locations":"text":"","title":"","link":null,"lat":47.838435,"lon":-100.665669,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""...

  3. MiR-153 inhibits migration and invasion of human non-small-cell lung cancer by targeting ADAM19

    SciTech Connect

    Shan, Nianxi; Shen, Liangfang; Wang, Jun; He, Dan; Duan, Chaojun

    2015-01-02

    Highlights: • Decreased miR-153 and up-regulated ADAM19 are correlated with NSCLC pathology. • MiR-153 inhibits the proliferation and migration and invasion of NSCLC cells in vitro. • ADAM19 is a direct target of miR-153. • ADAM19 is involved in miR-153-suppressed migration and invasion of NSCLC cells. - Abstract: MiR-153 was reported to be dysregulated in some human cancers. However, the function and mechanism of miR-153 in lung cancer cells remains unknown. In this study, we investigated the role of miR-153 in human non-small-cell lung cancer (NSCLC). Using qRT-PCR, we demonstrated that miR-153 was significantly decreased in clinical NSCLC tissues and cell lines, and downregulation of miR-153 was significantly correlated with lymph node status. We further found that ectopic expression of miR-153 significantly inhibited the proliferation and migration and invasion of NSCLC cells in vitro, suggesting that miR-153 may be a novel tumor suppressor in NSCLC. Further integrated analysis revealed that ADAM19 is as a direct and functional target of miR-153. Luciferase reporter assay demonstrated that miR-153 directly targeted 3′UTR of ADAM19, and correlation analysis revealed an inverse correlation between miR-153 and ADAM19 mRNA levels in clinical NSCLC tissues. Knockdown of ADAM19 inhibited migration and invasion of NSCLC cells which was similar with effects of overexpression of miR-153, while overexpression of ADAM19 attenuated the function of miR-153 in NSCLC cells. Taken together, our results highlight the significance of miR-153 and ADAM19 in the development and progression of NSCLC.

  4. miR-129 suppresses tumor cell growth and invasion by targeting PAK5 in hepatocellular carcinoma

    SciTech Connect

    Zhai, Jian; Qu, Shuping; Li, Xiaowei; Zhong, Jiaming; Chen, Xiaoxia; Qu, Zengqiang; Wu, Dong

    2015-08-14

    Emerging evidence suggests that microRNAs (miRNAs) play important roles in regulating HCC development and progression; however, the mechanisms by which their specific functions and mechanisms remained to be further explored. miR-129 has been reported in gastric cancers, lung cancer and colon cancer. In this study, we disclosed a new tumor suppresser function of miR-129 in HCC. We also found the downregulation of miR-129 occurred in nearly 3/4 of the tumors examined (56/76) compared with adjacent nontumorous tissues, which was more importantly, correlated to the advanced stage and vascular invasion. We then demonstrated that miR-129 overexpression attenuated HCC cells proliferation and invasion, inducing apoptosis in vitro. Moreover, we used miR-129 antagonist and found that anti-miR-129 promoted HCC cells malignant phenotypes. Mechanistically, our further investigations revealed that miR-129 suppressed cell proliferation and invasion by targeting the 3’-untranslated region of PAK5, as well as miR-129 silencing up-regulated PAK5 expression. Moreover, miR-129 expression was inversely correlated with PAK5 expression in 76 cases of HCC samples. RNA interference of PAK5 attenuated anti-miR-129 mediated cell proliferation and invasion in HCC cells. Taken together, these results demonstrated that miR-129 suppressed tumorigenesis and progression by directly targeting PAK5, defining miR-129 as a potential treatment target for HCC. - Highlights: • Decreased of miR-129 is found in HCC and associated with advanced stage and metastasis. • miR-129 suppresses proliferation and invasion of HCC cells. • miR-129 directly targets the 3′ UTR of PAK5 and diminishes PAK5 expression. • PAK5 is involved in miR-129 mediated suppression functions.

  5. Analysis of Network Address Shuffling as a Moving Target Defense

    SciTech Connect

    Carroll, Thomas E.; Crouse, Michael B.; Fulp, Errin W.; Berenhaut, Kenneth S.

    2014-06-10

    Address shuffling is a type of moving target defense that prevents an attacker from reliably contacting a system by periodically remapping network addresses. Although limited testing has demonstrated it to be effective, little research has been conducted to examine the theoretical limits of address shuffling. As a result, it is difficult to understand how effective shuffling is and under what circumstances it is a viable moving target defense. This paper introduces probabilistic models that can provide insight into the performance of address shuffling. These models quantify the probability of attacker success in terms of network size, quantity of addresses scanned, quantity of vulnerable systems, and the frequency of shuffling. Theoretical analysis will show that shuffling is an acceptable defense if there is a small population of vulnerable systems within a large network address space, however shuffling has a cost for legitimate users. These results will also be shown empirically using simulation and actual traffic traces.

  6. Transcriptional regulation of miR-146b by C/EBPβ LAP2 in esophageal cancer cells

    SciTech Connect

    Li, Junxia; Shan, Fabo; Xiong, Gang; Wang, Ju-Ming; Wang, Wen-Lin; Xu, Xueqing; Bai, Yun

    2014-03-28

    Highlights: • MiR-146b promotes esophageal cancer cell proliferation. • MiR-146b inhibits esophageal cancer cell apoptosis. • C/EBPβ directly binds to miR-146b promoter conserved region. • MiR-146b is up-regulated by C/EBPβ LAP2 transcriptional activation. - Abstract: Recent clinical study indicated that up-regulation of miR-146b was associated with poor overall survival of patients in esophageal squamous cell carcinoma. However, the underlying mechanism of miR-146b dysregulation remains to be explored. Here we report that miR-146b promotes cell proliferation and inhibits cell apoptosis in esophageal cancer cell lines. Mechanismly, two C/EBPβ binding motifs are located in the miR-146b promoter conserved region. Among the three isoforms of C/EBPβ, C/EBPβ LAP2 positively regulated miR-146b expression and increases miR-146b levels in a dose-dependent manner through transcription activation of miR-146b gene. Together, these results suggest a miR-146b regulatory mechanism involving C/EBPβ, which may contribute to the up-regulation of miR-146b in esophageal squamous cell carcinoma.

  7. Secretary Chu Addresses the International Atomic Energy Agency General

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Conference | Department of Energy Addresses the International Atomic Energy Agency General Conference Secretary Chu Addresses the International Atomic Energy Agency General Conference September 20, 2010 - 12:00am Addthis Washington, DC - U.S. Energy Secretary Steven Chu addressed the International Atomic Energy Agency's 54th General Conference today in Vienna. His prepared remarks are below: Thank you, Ambassador Enkhsaikhan. Congratulations on your election as President of this Conference.

  8. Executive Order 12898: Federal Actions to Address Environmental Justice in

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Minority Populations and Low-Income Populations (1994) | Department of Energy 2898: Federal Actions to Address Environmental Justice in Minority Populations and Low-Income Populations (1994) Executive Order 12898: Federal Actions to Address Environmental Justice in Minority Populations and Low-Income Populations (1994) Executive Order 12898: Federal Actions to Address Environmental Justice in Minority Populations and Low-Income Populations (1994). Directs each federal agency to make

  9. Abraham Calls on Global Community to Aggressively Address Nuclear

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Nonproliferation | Department of Energy Abraham Calls on Global Community to Aggressively Address Nuclear Nonproliferation Abraham Calls on Global Community to Aggressively Address Nuclear Nonproliferation January 13, 2005 - 9:49am Addthis WASHINGTON, DC - In a lunchtime speech to the Council on Foreign Relations in Washington, DC, Energy Secretary Spencer Abraham called on the global community to join in implementing a comprehensive nuclear nonproliferation strategy to address 21st century

  10. Utility Regulation and Business Model Reforms for Addressing the Financial

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Impacts of Distributed Solar on Utilities | Department of Energy Utility Regulation and Business Model Reforms for Addressing the Financial Impacts of Distributed Solar on Utilities Utility Regulation and Business Model Reforms for Addressing the Financial Impacts of Distributed Solar on Utilities Utility Regulation and Business Model Reforms for Addressing the Financial Impacts of Distributed Solar on Utilities Implementing a range of alternative utility-rate reforms could minimize solar

  11. Working Together to Address Natural Gas Storage Safety | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energy Together to Address Natural Gas Storage Safety Working Together to Address Natural Gas Storage Safety April 1, 2016 - 11:15am Addthis Working Together to Address Natural Gas Storage Safety Franklin (Lynn) Orr Franklin (Lynn) Orr Under Secretary for Science and Energy Marie Therese Dominguez Marie Therese Dominguez Administrator, U.S. Department of Transportation's Pipeline and Hazardous Materials Safety Administration As a part of the Administration's ongoing commitment to support

  12. Headquarters Program & Staff Office Mailing Addresses | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energy Headquarters Program & Staff Office Mailing Addresses Headquarters Program & Staff Office Mailing Addresses The following addresses are for delivery of regular mail and small packages: Delivery to the Headquarters buildings in Washington, DC: Name of Individual Title Routing Symbol/Forrestal Building U.S. Department of Energy 1000 Independence Ave., S.W. Washington, DC 20585 Name of Individual Title Routing Symbol/L'Enfant Plaza Building U.S. Department of Energy 1000

  13. Bush Administration Plays Leading Role in Studying and Addressing Global

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Climate Change | Department of Energy Plays Leading Role in Studying and Addressing Global Climate Change Bush Administration Plays Leading Role in Studying and Addressing Global Climate Change February 27, 2007 - 3:49pm Addthis Washington, DC - Continuing to take the lead in addressing global climate change, Energy Secretary Samuel Bodman, Environmental Protection Agency (EPA) Administrator Stephen Johnson, and National Oceanic and Atmospheric Administration (NOAA) Administrator Vice

  14. Steffes Corporation Smart Grid RFI: Addressing Policy and Logistical

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Challenges | Department of Energy Steffes Corporation Smart Grid RFI: Addressing Policy and Logistical Challenges Steffes Corporation Smart Grid RFI: Addressing Policy and Logistical Challenges Steffes Corporation Smart Grid RFI: Addressing Policy and Logistical Challenges. The Department of Energy is seeking comments on policy and logistical challenges that confront smart grid implementation, as well as recommendations on how to best overcome those challenges. Steffes Corporation Smart Grid

  15. Upcoming Webinars to Focus on Topics Addressed in the National...

    Office of Environmental Management (EM)

    and computational research that must be addressed for the next-generation electric transmission and distribution system. The report also includes a series of recommendations. ...

  16. Ambient Corporation's Reply comments to DOE RFI: Addressing Policy...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    to DOE RFI: Addressing Policy and Logistical Challenges to Smart Grid Implementation Ambient Corporation's ... to deploy cost-effective long-term smart grid benefits. ...

  17. Smart Grid RFI: Addressing Policy and Logistical Challenges,...

    Energy.gov [DOE] (indexed site)

    Reliability and Resiliency of the US Electric Grid: SGIG Article in Metering International, March 2012 Smart Grid Consortium, Response of New York State Smart Grid Addressing ...

  18. Global Gathering Addresses PV Role in Energy Prosperity and Climate...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Global Gathering Addresses PV Role in Energy Prosperity and Climate Change Mitigation March 30, 2016 Scientists from the Energy Department's National Renewable Energy Laboratory ...

  19. New partnership uses advanced computer science modeling to address...

    National Nuclear Security Administration (NNSA)

    partnership uses advanced computer science modeling to address climate change Friday, August 29, 2014 - 10:26am Several national laboratories and institutions have joined forces to ...

  20. Addressing Climate Change with Next Generation Energy Storage...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    March 19, 2015, Videos Addressing Climate Change with Next Generation Energy Storage Technology George Crabtree gives keynote at Loyola University In March 2015, George Crabtree ...

  1. Pensacola Smart Grid RFI Addressing Policy and Logistical Challenges...

    Energy Saver

    Pensacola Smart Grid RFI Addressing Policy and Logistical Challenges. Providing comment on: Consumer facing programs such as feedback, demandresponse, energy efficiency, and ...

  2. Addressing the Voltage Fade Issue with Lithium-Manganese-Rich...

    Energy.gov [DOE] (indexed site)

    More Documents & Publications Studies on Lithium Manganese Rich MNC Composite Cathodes ... Addressing the Voltage Fade Issue with Lithium-Manganese-Rich Oxide Cathode Materials

  3. Smart Grid RFI: Addressing Policy and Logistical Challenges....

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Challenges. Comments of the Alliance to Save Energy. Smart Grid RFI: Addressing Policy and Logistical Challenges. Comments of the Alliance to Save Energy. The Alliance to Save ...

  4. Addressing Biomass Supply Chain Challenges With AFEX™ Technology

    Energy.gov [DOE]

    Plenary IV: Advances in Bioenergy Feedstocks—From Field to Fuel Addressing Biomass Supply Chain Challenges With AFEX™ Technology Allen Julian, Chief Business Officer, MBI

  5. Africa - Technical Potential of Solar Energy to Address Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    - Technical Potential of Solar Energy to Address Energy Poverty and Avoid GHG Emissions Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Technical Potential of Solar...

  6. Address (Smart Grid Project) (France) | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    France) Jump to: navigation, search Project Name Address Country France Coordinates 46.073231, 2.427979 Loading map... "minzoom":false,"mappingservice":"googlemaps3","type":"R...

  7. Addressing Biomass Supply Chain Challenges With AFEX(tm) Technology...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Plenary IV: Advances in Bioenergy Feedstocks-From Field to Fuel Addressing Biomass Supply Chain Challenges With AFEX(tm) Technology Allen Julian, Chief Business Officer, MBI ...

  8. Addressing Policy and Logistical Challenges to Smart Grid Implementati...

    Office of Environmental Management (EM)

    Addressing Policy and Logistical Challenges to Smart Grid Implementation: Federal Register ... The Department of Energy (DOE) is seeking comments from interested parties on policy and ...

  9. Addressing Challenging Materials at Oak Ridge National Laboratory...

    Office of Scientific and Technical Information (OSTI)

    Title: Addressing Challenging Materials at Oak Ridge National Laboratory No abstract prepared. Authors: Jubin, Robert Thomas 1 ; Patton, Bradley D 1 ; Robinson, Sharon M 1 ; ...

  10. Method for the electro-addressable functionalization of electrode...

    Office of Scientific and Technical Information (OSTI)

    Title: Method for the electro-addressable functionalization of electrode arrays A method for preparing an electrochemical biosensor uses bias-assisted assembly of unreactive -onium ...

  11. Method for the electro-addressable functionalization of electrode...

    Office of Scientific and Technical Information (OSTI)

    A method for preparing an electrochemical biosensor uses bias-assisted assembly of unreactive -onium molecules on an electrode array followed by post-assembly electro-addressable ...

  12. Addressing Barriers to Upgrade Projects at Affordable Multifamily Properties (201)

    Energy.gov [DOE]

    Better Buildings Residential Network Peer Exchange Call Series: Addressing Barriers to Upgrade Projects at Affordable Multifamily Properties (201), call slides and discussion summary.

  13. Strategies to Address Split Incentives in Multifamily Buildings

    Energy.gov [DOE]

    Better Buildings Neighborhood Program Multifamily / Low-Income Peer Exchange Call: Strategies to Address Split Incentives in Multifamily Buildings, Call Slides and Discussion Summary, April 26, 2012.

  14. New York Independent System Operator, Smart Grid RFI: Addressing...

    Office of Environmental Management (EM)

    New York Independent System Operator, Smart Grid RFI: Addressing Policy and Logistical ... September 17, 2010 Federal Register, the New York Independent System Operator, Inc. ...

  15. Addressing the Voltage Fade Issue with Lithium-Manganese-Rich...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Addressing the Voltage Fade Issue with Lithium-Manganese-Rich Oxide Cathode Materials 2013 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Program Annual Merit Review ...

  16. Synthetic Biology for Advanced Fuels (Opening Keynote Address...

    Office of Scientific and Technical Information (OSTI)

    Synthetic Biology for Advanced Fuels (Opening Keynote Address - 2010 JGI User Meeting) Citation Details In-Document Search Title: Synthetic Biology for Advanced Fuels (Opening ...

  17. Research Projects to Address Technical Challenges Facing Small...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Facing Small Oil and Natural Gas Producers Selected by DOE for Further Development Research Projects to Address Technical Challenges Facing Small Oil and Natural Gas ...

  18. Method for the electro-addressable functionalization of electrode...

    Office of Scientific and Technical Information (OSTI)

    Electro-addressable functionalization of electrode arrays enables the multi-target electrochemical sensing of biological and chemical analytes. Authors: Harper, Jason C. ; Polsky, ...

  19. Microsoft Word - Actions to address lessons learned.doc

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Actions to address Work Planning and Scheduling System lessons learned Action Executive owner Staff assigned Due date Understand the business environment of vendor references....

  20. Towards Addressing Surface Effects in Ordinary Isotropic Peridynamic...

    Office of Scientific and Technical Information (OSTI)

    Towards Addressing Surface Effects in Ordinary Isotropic Peridynamic Models Position Aware ... Resource Relation: Conference: SIAM Conference on 'Analysis of Partial Differential ...

  1. miR-1297 mediates PTEN expression and contributes to cell progression in LSCC

    SciTech Connect

    Li, Xin; Wang, Hong-liang; Peng, Xin; Zhou, Hui-fang; Wang, Xin

    2012-10-19

    Highlights: Black-Right-Pointing-Pointer miR-1297 was found to be overexpressed in LSCC and contribute to the cell progression. Black-Right-Pointing-Pointer PTEN was confirmed to be a target gene of miR-1297. Black-Right-Pointing-Pointer Downregulation of PTEN can rescue the proliferation and invasion ability of miR-1297 downregulated Hep-2 cells. Black-Right-Pointing-Pointer Downregulation of miR-1297 inhibits tumor growth in vivo. -- Abstract: MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression after transcription, and are involved in cancer development. Laryngeal squamous cell carcinoma (LSCC) is one of the most common malignant neoplasms with increasing incidence in recent years. In this paper, we report the overexpression of miR-1297 in LSCC and Hep-2 cells. In addition, PTEN was identified to be directly regulated by miR-1297 through western blot and luciferase activity assay. Furthermore, downregulation of miR-1297 in Hep-2 cells was shown to inhibit cancer cell proliferation, migration, and tumor genesis. Our results document a new epigenetic mechanism for PTEN regulation in LSCC, which is crucial for the development of these tumors.

  2. miR-30a suppresses breast cancer cell proliferation and migration by targeting Eya2

    SciTech Connect

    Fu, Jing; Xu, Xiaojie; Kang, Lei; Zhou, Liying; Wang, Shibin; Lu, Juming; Cheng, Long; Fan, Zhongyi; Yuan, Bin; Tian, Peirong; Zheng, Xiaofei; Yu, Chengze; Ye, Qinong; Lv, Zhaohui

    2014-03-07

    Highlights: • miR-30a represses Eya2 expression by binding to the 3′-untranslated region of Eya2. • The miR-30a/EYA2 axis regulates breast cancer cell proliferation and migration. • The miR-30a/EYA2 axis modulates G1/S cell cycle progression. • The miR-30a/EYA2 axis is dysregulated in breast cancer patients. - Abstract: Eye absent (Eya) proteins are involved in cell fate determination in a broad spectrum of cells and tissues. Aberrant expression of Eya2 has been documented in a variety of cancers and correlates with clinical outcome. However, whether microRNAs (miRNAs) can regulate Eya2 expression remains unknown. Here, we show that miR-30a represses Eya2 expression by binding to the 3′-untranslated region of Eya2. Overexpression of Eya2 in miR-30a-transfected breast cancer cells effectively rescued the inhibition of cell proliferation and migration caused by miR-30a. Knockdown of Eya2 by small-interfering RNA (siRNA) in breast cancer cells mimicked the effect induced by miR-30a and abolished the ability of miR-30a to regulate breast cancer cell proliferation and migration. The miR-30a/Eya2 axis could regulate G1/S cell cycle progression, accompanied by the modulation of expression of cell cycle-related proteins, including cyclin A, cyclin D1, cyclin E, and c-Myc. Moreover, miR-30a expression was downregulated in breast cancer patients, and negatively correlated with Eya2, which was upregulated in breast cancer patients. These data suggest that the miR-30a/Eya2 axis may play an important role in breast cancer development and progression and that miR-30a activation or Eya2 inhibition may be a useful strategy for cancer treatment.

  3. miR-21 modulates resistance of HR-HPV positive cervical cancer cells to radiation through targeting LATS1

    SciTech Connect

    Liu, Shikai; Song, Lili Zhang, Liang; Zeng, Saitian; Gao, Fangyuan

    2015-04-17

    Although multiple miRNAs are found involved in radioresistance development in HR-HPV positive (+) cervical cancer, only limited studies explored the regulative mechanism of the miRNAs. miR-21 is one of the miRNAs significantly upregulated in HR-HPV (+) cervical cancer is also significantly associated with radioresistance. However, the detailed regulative network of miR-21 in radioresistance is still not clear. In this study, we confirmed that miR-21 overexpression was associated with higher level of radioresistance in HR-HPV (+) cervical cancer patients and thus decided to further explore its role. Findings of this study found miR-21 can negatively affect radiosensitivity of HR-HPV (+) cervical cancer cells and decrease radiation induced G2/M block and increase S phase accumulation. By using dual luciferase assay, we verified a binding site between miR-21 and 3′-UTR of large tumor suppressor kinase 1 (LATS1). Through direct binding, miR-21 can regulate LATS1 expression in cervical cancer cells. LATS1 overexpression can reverse miR-21 induced higher colony formation rate and also reduced miR-21 induced S phase accumulation and G2/M phase block reduction under radiation treatment. These results suggested that miR-21-LATS1 axis plays an important role in regulating radiosensitivity. - Highlights: • miR-21 is highly expressed in HR-HPV (+) radioresistant cervical cancer patients. • miR-21 can negatively affect radiosensitivity of HR-HPV (+) cervical cancer cells. • miR-21 can decrease radiation induced G2/M block and increase S phase accumulation. • miR-21 modulates radiosensitivity cervical cancer cell by directly targeting LATS1.

  4. miR-92a is upregulated in cervical cancer and promotes cell proliferation and invasion by targeting FBXW7

    SciTech Connect

    Zhou, Chuanyi; Shen, Liangfang; Mao, Lei; Wang, Bing; Li, Yang; Yu, Huizhi

    2015-02-27

    MicroRNAs (miRNAs) are involved in the cervical carcinogenesis and progression. In this study, we investigated the role of miR-92a in progression and invasion of cervical cancer. MiR-92a was significantly upregulated in cervical cancer tissues and cell lines. Overexpression of miR-92a led to remarkably enhanced proliferation by promoting cell cycle transition from G1 to S phase and significantly enhanced invasion of cervical cancer cells, while its knockdown significantly reversed these cellular events. Bioinformatics analysis suggested F-box and WD repeat domain-containing 7 (FBXW7) as a novel target of miR-92a, and miR-92a suppressed the expression level of FBXW7 mRNA by direct binding to its 3′-untranslated region (3′UTR). Expression of miR-92a was negatively correlated with FBXW7 in cervical cancer tissues. Furthermore, Silencing of FBXW7 counteracted the effects of miR-92a suppression, while its overexpression reversed oncogenic effects of miR-92a. Together, these findings indicate that miR-92a acts as an onco-miRNA and may contribute to the progression and invasion of cervical cancer, suggesting miR-92a as a potential novel diagnostic and therapeutic target of cervical cancer. - Highlights: • miR-92a is elevated in cervical cancer tissues and cell lines. • miR-92a promotes cervical cancer cell proliferation, cell cycle transition from G1 to S phase and invasion. • FBXW7 is a direct target of miR-92a. • FBXW7 counteracts the oncogenic effects of miR-92a on cervical cancer cells.

  5. Keynote Address: Ali Zaidi, the White House Domestic Policy Council |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Ali Zaidi, the White House Domestic Policy Council Keynote Address: Ali Zaidi, the White House Domestic Policy Council May 21, 2014 2:05PM to 2:30PM PDT Pacific Ballroom Keynote address by Ali Zaidi, Deputy Director for Energy Policy, the White House Domestic Policy Council

  6. Symbiosis: Addressing Biomass Production Challenges and Climate Change |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Symbiosis: Addressing Biomass Production Challenges and Climate Change Symbiosis: Addressing Biomass Production Challenges and Climate Change This presentation was the opening keynote of the Symbiosis Conference. symbiosis_conference_hamilton.pdf (1.4 MB) More Documents & Publications The Future of Bioenergy Feedstock Production Symbiosis Biofeedstock Conference: Expanding Commercialization of Mutualistic Microbes to Increase Feedstock Production Symbiosis

  7. Method for the electro-addressable functionalization of electrode arrays

    SciTech Connect

    Harper, Jason C.; Polsky, Ronen; Dirk, Shawn M.; Wheeler, David R.; Arango, Dulce C.; Brozik, Susan M.

    2015-12-15

    A method for preparing an electrochemical biosensor uses bias-assisted assembly of unreactive -onium molecules on an electrode array followed by post-assembly electro-addressable conversion of the unreactive group to a chemical or biological recognition group. Electro-addressable functionalization of electrode arrays enables the multi-target electrochemical sensing of biological and chemical analytes.

  8. IP address management : augmenting Sandia's capabilities through open source tools.

    SciTech Connect

    Nayar, R. Daniel

    2005-08-01

    Internet Protocol (IP) address management is an increasingly growing concern at Sandia National Laboratories (SNL) and the networking community as a whole. The current state of the available IP addresses indicates that they are nearly exhausted. Currently SNL doesn't have the justification to obtain more IP address space from Internet Assigned Numbers Authority (IANA). There must exist a local entity to manage and allocate IP assignments efficiently. Ongoing efforts at Sandia have been in the form of a multifunctional database application notably known as Network Information System (NWIS). NWIS is a database responsible for a multitude of network administrative services including IP address management. This study will explore the feasibility of augmenting NWIS's IP management capabilities utilizing open source tools. Modifications of existing capabilities to better allocate available IP address space are studied.

  9. Marysville, MI Natural Gas Pipeline Imports From Canada (Million Cubic

    Energy Information Administration (EIA) (indexed site)

    Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 10 1,827 135 2000's NA NA 74 0 303 0 24 876 2,252 5,651 2010's 5,694 9,946 8,099 2,337 4,650 1,961 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Natural Gas Pipeline Imports by Point of Entry Marysville, MI Natural Gas Imports by Pipeli

  10. Marysville, MI Natural Gas Pipeline Imports From Canada (Dollars per

    Energy Information Administration (EIA) (indexed site)

    Thousand Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 3.48 2.17 2.06 2000's NA NA 3.95 -- 7.80 -- 7.07 7.59 8.59 3.80 2010's 4.44 4.42 2.99 4.15 6.86 2.73 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Price of Natural Gas Pipeline Imports by Point of Entry Marysville, MI Natural Gas

  11. NuMI proton kicker extraction magnet termination resistor system

    SciTech Connect

    Reeves, S.R.; Jensen, C.C.; /Fermilab

    2005-05-01

    The temperature stability of the kicker magnet termination resistor assembly directly affects the field flatness and amplitude stability. Comprehensive thermal enhancements were made to the existing Main Injector resistor assembly design to satisfy NuMI performance specifications. Additionally, a fluid-processing system utilizing Fluorinert{reg_sign} FC-77 high-voltage dielectric was built to precisely control the setpoint temperature of the resistor assembly from 70 to 120F, required to maintain constant resistance during changing operational modes. The Fluorinert{reg_sign} must be continually processed to remove hazardous breakdown products caused by radiation exposure to prevent chemical attack of system components. Design details of the termination resistor assembly and Fluorinert{reg_sign} processing system are described. Early performance results will be presented.

  12. Non-canonical microRNAs miR-320 and miR-702 promote proliferation in Dgcr8-deficient embryonic stem cells

    SciTech Connect

    Kim, Byeong-Moo; Choi, Michael Y.

    2012-09-21

    Highlights: Black-Right-Pointing-Pointer Embryonic stem cells (ESCs) lacking non-canonical miRNAs proliferate slower. Black-Right-Pointing-Pointer miR-320 and miR-702 are two non-canonical miRNAs expressed in ESCs. Black-Right-Pointing-Pointer miR-320 and miR-702 promote proliferation of Dgcr8-deficient ESCs. Black-Right-Pointing-Pointer miR-320 targets p57 and helps to release Dgcr8-deficient ESCs from G1 arrest. Black-Right-Pointing-Pointer miR-702 targets p21 and helps to release Dgcr8-deficient ESCs from G1 arrest. -- Abstract: MicroRNAs are known to contribute significantly to stem cell phenotype by post-transcriptionally regulating gene expression. Most of our knowledge of microRNAs comes from the study of canonical microRNAs that require two sequential cleavages by the Drosha/Dgcr8 heterodimer and Dicer to generate mature products. In contrast, non-canonical microRNAs bypass the cleavage by the Drosha/Dgcr8 heterodimer within the nucleus but still require cytoplasmic cleavage by Dicer. The function of non-canonical microRNAs in embryonic stem cells (ESCs) remains obscure. It has been hypothesized that non-canonical microRNAs have important roles in ESCs based upon the phenotypes of ESC lines that lack these specific classes of microRNAs; Dicer-deficient ESCs lacking both canonical and non-canonical microRNAs have much more severe proliferation defect than Dgcr8-deficient ESCs lacking only canonical microRNAs. Using these cell lines, we identified two non-canonical microRNAs, miR-320 and miR-702, that promote proliferation of Dgcr8-deficient ESCs by releasing them from G1 arrest. This is accomplished by targeting the 3 Prime -untranslated regions of the cell cycle inhibitors p57 and p21 and thereby inhibiting their expression. This is the first report of the crucial role of non-canonical microRNAs in ESCs.

  13. MOLTEN CARBONATE FUEL CELL POWER PLANT LOCATED AT LADWP MAIN STREET SERVICE CENTER

    SciTech Connect

    William W. Glauz

    2004-09-10

    The Los Angeles Department of Water and Power (LADWP) has developed one of the most recognized fuel cell demonstration programs in the United States. In addition to their high efficiencies and superior environmental performance, fuel cells and other generating technologies that can be located at or near the load, offers several electric utility benefits. Fuel cells can help further reduce costs by reducing peak electricity demand, thereby deferring or avoiding expenses for additional electric utility infrastructure. By locating generators near the load, higher reliability of service is possible and the losses that occur during delivery of electricity from remote generators are avoided. The potential to use renewable and locally available fuels, such as landfill or sewage treatment waste gases, provides another attractive outlook. In Los Angeles, there are also many oil producing areas where the gas by-product can be utilized. In June 2000, the LADWP contracted with FCE to install and commission the precommercial 250kW MCFC power plant. The plant was delivered, installed, and began power production at the JFB in August 2001. The plant underwent manufacturer's field trials up for 18 months and was replace with a commercial plant in January 2003. In January 2001, the LADWP contracted with FCE to provide two additional 250kW MCFC power plants. These commercial plants began operations during mid-2003. The locations of these plants are at the Terminal Island Sewage Treatment Plant at the Los Angeles Harbor (for eventual operation on digester gas) and at the LADWP Main Street Service Center east of downtown Los Angeles. All three carbonate fuel cell plants received partial funding through the Department of Defense's Climate Change Fuel Cell Buydown Program. This report covers the technical evaluation and benefit-cost evaluation of the Main Street 250kW MCFC power plant during its first year of operation from September 2003 to August 2004. The data for the month of

  14. miR-182 targets CHL1 and controls tumor growth and invasion in papillary thyroid carcinoma

    SciTech Connect

    Zhu, Hongling; Fang, Jin; Zhang, Jichen; Zhao, Zefei; Liu, Lianyong; Wang, Jingnan; Xi, Qian; Gu, Mingjun

    2014-07-18

    Highlights: miR-182 and CHL1 expression patterns are negatively correlated. CHL1 is a direct target of miR-182 in PTC cells. miR-182 suppression inhibits PTC cell growth and invasion. CHL1 is involved in miR-182-mediated cell behavior. - Abstract: In this study, we investigated the role and underlying mechanism of action of miR-182 in papillary thyroid carcinoma (PTC). Bioinformatics analysis revealed close homolog of LI (CHL1) as a potential target of miR-182. Upregulation of miR-182 was significantly correlated with CHL1 downregulation in human PTC tissues and cell lines. miR-182 suppressed the expression of CHL1 mRNA through direct targeting of the 3?-untranslated region (3?-UTR). Downregulation of miR-182 suppressed growth and invasion of PTC cells. Silencing of CHL1 counteracted the effects of miR-182 suppression, while its overexpression mimicked these effects. Our data collectively indicate that miR-182 in PTC promotes cell proliferation and invasion through direct suppression of CHL1, supporting the potential utility of miR-182 inhibition as a novel therapeutic strategy against PTC.

  15. Downregulation of miRNA-30c and miR-203a is associated with hepatitis C virus core protein-induced epithelial–mesenchymal transition in normal hepatocytes and hepatocellular carcinoma cells

    SciTech Connect

    Liu, Dongjing; Wu, Jilin; Liu, Meizhou; Yin, Hui; He, Jiantai; Zhang, Bo

    2015-09-04

    Hepatitis C virus (HCV) Core protein has been demonstrated to induce epithelial–mesenchymal transition (EMT) and is associated with cancer progression of hepatocellular carcinoma (HCC). However, how the Core protein regulates EMT is still unclear. In this study, HCV Core protein was overexpressed by an adenovirus. The protein levels of EMT markers were measured by Western blot. The xenograft animal model was established by inoculation of HepG2 cells. Results showed that ectopic expression of HCV core protein induced EMT in L02 hepatocytes and HepG2 tumor cells by upregulating vimentin, Sanl1, and Snal2 expression and downregulating E-cadherin expression. Moreover, Core protein downregulated miR-30c and miR-203a levels in L02 and HepG2 cells, but artificial expression of miR-30c and miR-203a reversed Core protein-induced EMT. Further analysis showed that ectopic expression of HCV core protein stimulated cell proliferation, inhibited apoptosis, and increased cell migration, whereas artificial expression of miR-30c and miR-203a significantly reversed the role of Core protein in these cell functions in L02 and HepG2 cells. In the HepG2 xenograft tumor models, artificial expression of miR-30c and miR-203a inhibited EMT and tumor growth. Moreover, L02 cells overexpressing Core protein can form tumors in nude mice. In HCC patients, HCV infection significantly shortened patients' survival time, and loss of miR-30c and miR-203 expression correlated with poor survival. In conclusion, HCV core protein downregulates miR-30c and miR-203a expression, which results in activation of EMT in normal hepatocytes and HCC tumor cells. The Core protein-activated-EMT is involved in the carcinogenesis and progression of HCC. Loss of miR-30c and miR-203a expression is a marker for the poor prognosis of HCC. - Highlights: • HCV core protein downregulates miR-30c and miR-203a expression. • Downregulation of miR-30c and miR-203a activates EMT. • Activated-EMT is involved in the

  16. JLab will test its Public Address System | Jefferson Lab

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    will test its Public Address System Wednesday, Sept. 28 at 5:30 p.m.: JLab will test its Public Address System On Wednesday, Sept. 28, Emergency Management Team staff will conduct the monthly test of Jefferson Lab's Public Address (PA) System - the live audible announcement feature - available through the lab's Cisco phones. This monthly operational test of the system occurs at 5:30 p.m. on the third Wednesday of each month. No actions are required or expected from members of the lab community

  17. miR-128 and its target genes in tumorigenesis and metastasis

    SciTech Connect

    Li, Molin, E-mail: molin_li@hotmail.com [Dalian Medical University, Dalian 116044 (China); Fu, Weiming [Center for Food Safety and Environmental Technology, Guangzhou Institute of Advanced Technology, Chinese Academy of Sciences, Guangzhou 511458 (China); Wo, Lulu; Shu, Xiaohong [Dalian Medical University, Dalian 116044 (China); Liu, Fang [The second affiliated hospital of Dalian Medical University, Dalian 116023 (China); Li, Chuangang, E-mail: li_chuangang@sina.com [The second affiliated hospital of Dalian Medical University, Dalian 116023 (China)

    2013-12-10

    MicroRNAs (miRNAs) are a class of endogenous, non-coding, 1824 nucleotide length single-strand RNAs that could modulate gene expression at post-transcriptional level. Previous studies have shown that miR-128 enriched in the brain plays an important role in the development of nervous system and the maintenance of normal physical functions. Aberrant expression of miR-128 has been detected in many types of human tumors and its validated target genes are involved in cancer-related biological processes such as cell proliferation, differentiation and apoptosis. In this review, we will summarize the roles of miR-128 and its target genes in tumorigenesis and metastasis. - Highlights: Aberrant expression of miR-128 can be observed in many kinds of malignant tumors. The molecular mechanisms regulating miR-128 expression are elucidated. Roles of miR-128 and its target genes in tumorigenesis and metastasis are summarized.

  18. miR-125b inhibits osteoblastic differentiation by down-regulation of cell proliferation

    SciTech Connect

    Mizuno, Yosuke; Yagi, Ken; Tokuzawa, Yoshimi; Kanesaki-Yatsuka, Yukiko; Suda, Tatsuo; Katagiri, Takenobu; Fukuda, Toru; Maruyama, Masayoshi; Okuda, Akihiko; Amemiya, Tomoyuki; Kondoh, Yasumitsu; Tashiro, Hideo; Okazaki, Yasushi

    2008-04-04

    Although various microRNAs regulate cell differentiation and proliferation, no miRNA has been reported so far to play an important role in the regulation of osteoblast differentiation. Here we describe the role of miR-125b in osteoblastic differentiation in mouse mesenchymal stem cells, ST2, by regulating cell proliferation. The expression of miR-125b was time-dependently increased in ST2 cells, and the increase in miR-125b expression was attenuated in osteoblastic-differentiated ST2 cells induced by BMP-4. The transfection of exogenous miR-125b inhibited proliferation of ST2 cells and caused inhibition of osteoblastic differentiation. In contrast, when the endogenous miR-125b was blocked by transfection of its antisense RNA molecule, alkaline phosphatase activity after BMP-4 treatment was elevated. These results strongly suggest that miR-125b is involved in osteoblastic differentiation through the regulation of cell proliferation.

  19. The State of the Ames Laboratory Address 2011

    ScienceCinema

    King, Alex

    2013-03-01

    Alex King, director of The Ames Laboratory, discusses the budget situation, improvements at Ames Lab and infrastructure improvements during the State of the Lab address on Tuesday, May 24, 2011.

  20. JLab Will Test its Public Address System | Jefferson Lab

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    June 22 at 5:30 p.m.: JLab Will Test its Public Address System On Wednesday, June 22, Emergency Management Team staff will conduct the monthly test of Jefferson Lab's Public ...

  1. JLab Will Test its Public Address System | Jefferson Lab

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    July 20 at 5:30 p.m.: JLab Will Test its Public Address System On Wednesday, July 20, Emergency Management Team staff will conduct the monthly test of Jefferson Lab's Public ...

  2. Keynote Address: Cristin Dorgelo, White House Office of Science...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Cristin Dorgelo, White House Office of Science and Technology Policy Keynote Address: Cristin Dorgelo, White House Office of Science and Technology Policy May 21, 2014 2:20PM to ...

  3. Keynote Address: Ali Zaidi, the White House Domestic Policy Council...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Ali Zaidi, the White House Domestic Policy Council Keynote Address: Ali Zaidi, the White House Domestic Policy Council May 21, 2014 2:05PM to 2:30PM PDT Pacific Ballroom Keynote...

  4. The INL Seismic Risk Assessment Project: Requirements for Addressing...

    Office of Environmental Management (EM)

    The INL Seismic Risk Assessment Project: Requirements for Addressing DOE Order 420.1C & A Proposed Generic Methodology Presentation from the May 2015 Seismic Lessons-Learned Panel ...

  5. Corrective Action Plan Addressing the Accident Investigation Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Corrective Action Plan Addressing the Accident Investigation Report of the February 5, 2014 Fire Event and the February 14, 2014 Radiological Release Event, Rev 1 Page 2 of 89 Table of Contents 1 Purpose ................................................................................................................................................................................................ 7 2 Summary of the

  6. Energy-Intensive Processes Portfolio: Addressing Key Energy Challenges...

    Energy.gov [DOE] (indexed site)

    research and development (r&d) portfolio for energy-Intensive Processes (eIP) addresses the top technology opportunities to save energy and reduce carbon emissions across the ...

  7. United Indigenous Voices Address Sustainability: Climate Change and Traditional Places

    Energy.gov [DOE]

    At the First Stewards Symposium, over 300 industry and policy leaders from around the nation will discuss four main themes generated from the 2012 First Stewards Symposium that address issues...

  8. miR-15a/16 Enhances Radiation Sensitivity of Non-Small Cell Lung Cancer

    Office of Scientific and Technical Information (OSTI)

    Cells by Targeting the TLR1/NF-κB Signaling Pathway (Journal Article) | SciTech Connect miR-15a/16 Enhances Radiation Sensitivity of Non-Small Cell Lung Cancer Cells by Targeting the TLR1/NF-κB Signaling Pathway Citation Details In-Document Search Title: miR-15a/16 Enhances Radiation Sensitivity of Non-Small Cell Lung Cancer Cells by Targeting the TLR1/NF-κB Signaling Pathway Purpose: Many miRNAs have been identified as essential issues and core determining factors in tumor radiation.

  9. Addressing Security and Reliability Concerns of Large Power Transformers |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Services » Addressing Security and Reliability Concerns of Large Power Transformers Addressing Security and Reliability Concerns of Large Power Transformers Large power transformers (LPTs) are critical to the nation's power grid, with more than 90 percent of consumed power passing through high-voltage transformers at some point. LPTs, however, face a number of challenges that make them one of the most vulnerable components on the grid. They are expensive, difficult to

  10. NAP Coalition Response to DOE RFI: Addressing Policy and Logistical

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Challenges to Smart Grid Implementation | Department of Energy NAP Coalition Response to DOE RFI: Addressing Policy and Logistical Challenges to Smart Grid Implementation NAP Coalition Response to DOE RFI: Addressing Policy and Logistical Challenges to Smart Grid Implementation The NAP Coalition is a "Coalition of Coalitions" that has been formed for the purpose of implementing the National Action Plan released by FERC in cooperation with DOE in June of 2010. Organizations working

  11. Okaloosa Gas District Smart Grid RFI: Addressing Policy and Logistical

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Challenges to Smart Grid Implementation | Department of Energy Okaloosa Gas District Smart Grid RFI: Addressing Policy and Logistical Challenges to Smart Grid Implementation Okaloosa Gas District Smart Grid RFI: Addressing Policy and Logistical Challenges to Smart Grid Implementation Okaloosa Gas District (The District) an Independent Special District of the State of Florida is appreciative of the opportunity to submit for your consideration the following comments in response to the U.S.

  12. Exploring the Utilization of Complex Algal Communities to Address Algal

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Pond Crash and Increase Annual Biomass Production for Algal Biofuels | Department of Energy Exploring the Utilization of Complex Algal Communities to Address Algal Pond Crash and Increase Annual Biomass Production for Algal Biofuels Exploring the Utilization of Complex Algal Communities to Address Algal Pond Crash and Increase Annual Biomass Production for Algal Biofuels white paper exploring complex algal communities as a means of increasing algal biomass production

  13. President Obama Praises NAMII in State of the Union Address

    Office of Energy Efficiency and Renewable Energy (EERE)

    In his 2013 State of the Union address, President Obama used the National Additive Manufacturing Institute (NAMII) as a model of the potential for innovation in manufacturing in the U.S. His address made it clear that his Administration is making the revitalization of the manufacturing sector a priority, stating that he plans to make the U.S. "a magnet for new jobs and manufacturing." He laid out a plan for spurring growth in manufacturing in the following statement:

  14. Keynote Address to the Western Governors' Association 2016 Annual Meeting

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    -- As Delivered | Department of Energy to the Western Governors' Association 2016 Annual Meeting -- As Delivered Keynote Address to the Western Governors' Association 2016 Annual Meeting -- As Delivered June 14, 2016 - 3:06pm Addthis Secretary Moniz's Keynote Address to the Western Governors' Association 2016 Annual Meeting Dr. Ernest Moniz Dr. Ernest Moniz Secretary of Energy Well, thank you. I had planned to say how pleased I was to be back with the Western Governors' Association.

  15. ADR Lunchtime Program: Addressing Unconscious Bias in the ADR Process |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Addressing Unconscious Bias in the ADR Process ADR Lunchtime Program: Addressing Unconscious Bias in the ADR Process This session focuses on strategies, issues, and insights into how unconscious bias impacts our perceptions, beliefs, and behaviors in today's workplace. Real-world case studies and current research are provided to increase awareness of the elements of the mediation/ADR process that may be impacted by biased communication and perception. The discussion

  16. ASHRAE draft regarding Smart Grid RFI: Addressing Policy and Logistical

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Challenges | Department of Energy ASHRAE draft regarding Smart Grid RFI: Addressing Policy and Logistical Challenges ASHRAE draft regarding Smart Grid RFI: Addressing Policy and Logistical Challenges The American Society of Heating, Refrigerating and Air-Conditioning Engineers Inc. (ASHRAE), founded in 1894, is an international organization of over 50,000 members. ASHRAE fulfills its mission of advancing heating, ventilation, air conditioning and refrigeration to serve humanity and promote a

  17. Ambient Corporation's Reply comments to DOE RFI: Addressing Policy and

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Logistical Challenges to Smart Grid Implementation | Department of Energy Ambient Corporation's Reply comments to DOE RFI: Addressing Policy and Logistical Challenges to Smart Grid Implementation Ambient Corporation's Reply comments to DOE RFI: Addressing Policy and Logistical Challenges to Smart Grid Implementation Ambient Corporation submits the following comments to the US Department of Energy (DOE) in hopes that their contribution can highlight and further the understanding of the DOE on

  18. EO 12898: Federal Actions to Address Environmental Justice in Minority

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Populations and Low-Income Populations (1994) | Department of Energy 898: Federal Actions to Address Environmental Justice in Minority Populations and Low-Income Populations (1994) EO 12898: Federal Actions to Address Environmental Justice in Minority Populations and Low-Income Populations (1994) Executive Order 12898 and an accompanying Presidential Memorandum were issued to focus Federal attention on the environmental and human health conditions in minority communities and low-income

  19. Addressing Policy and Logistical Challenges to Smart Grid Implementation

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Before the Department of Energy Washington, D.C. 20585 In the Matter of Addressing Policy and Logistical Challenges to Smart Grid Implementation Smart Grid RFI: Addressing Policy and Logistical Challenges COMMENTS OF BALTIMORE GAS & ELECTRIC COMPANY I. Introduction BGE is the nation's oldest utility company. It has met the energy needs of Central Maryland for nearly 200 years. Today, it serves more than 1.2 million business and residential electric customers and approximately 650,000 gas

  20. NETL's Supercomputer Addresses Energy Issues on Two Fronts | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energy Supercomputer Addresses Energy Issues on Two Fronts NETL's Supercomputer Addresses Energy Issues on Two Fronts September 26, 2013 - 10:42am Addthis The visualization center for the SBEUC (Simulation Based Engineering User Center). Located at the Department’s National Energy Technology Laboratory in Morgantown, W. Va., the SBEUC will be powered by a high performance computer that will allow researchers to simulate phenomena that are difficult or impossible to probe experimentally.

  1. DOE Awards Over a Billion Supercomputing Hours to Address Scientific

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Challenges | Department of Energy Over a Billion Supercomputing Hours to Address Scientific Challenges DOE Awards Over a Billion Supercomputing Hours to Address Scientific Challenges January 26, 2010 - 12:00am Addthis Washington, DC. - The U.S. Department of Energy announced today that approximately 1.6 billion supercomputing processor hours have been awarded to 69 cutting-edge research projects through the Innovative and Novel Computational Impact on Theory and Experiment (INCITE) program.

  2. NERSC Implements Organizational Changes to Better Address Evolving Data

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Environment Organizational Changes to Better Address Evolving Data Environment NERSC Implements Organizational Changes to Better Address Evolving Data Environment February 23, 2015 Contact: Jon Bashor, jbashor@lbl.gov, 510-486-5849 Sudip Dosanjh, director of the Department of Energy's National Energy Research Scientific Computing Center, announced several organizational changes to help the center's 6,000 users more productively manage their data-intensive research. The changes took effect

  3. Addressing Failures in Exascale Computing (Technical Report) | SciTech

    Office of Scientific and Technical Information (OSTI)

    Connect Technical Report: Addressing Failures in Exascale Computing Citation Details In-Document Search Title: Addressing Failures in Exascale Computing Authors: Snir, M. ; Wisniewski, R. W. ; Abraham, J. A. ; Adve, S. V. ; Bagchi, S. ; Balaji, P. ; Belak, J. ; Bose, P. ; Cappello, F. ; Carlson, B. ; Chien, A. A. ; Coteus, P. ; Debardeleben, N. A. ; Diniz, P. ; Engelmann, C. ; Erez, M. ; Fazzari, S. ; Geist, A. ; Gupta, R. ; Johnson, F. more »; Krishnamoorthy, S. ; Leyffer, S. ; Liberty, D.

  4. Role of CA Utility Programs in Addressing MELS

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Role of CA Utility Programs in addressing MELS Mangesh Basarkar, Emerging Technologies, PG&E DOE MELS Workshop Pacific Energy Center, San Francisco, June 3, 2016 OVERVIEW  Growing realization for utilities on the impact of miscellaneous electric loads (MELS) in buildings  Lot of ongoing data collection activities in support of products, programs and services for addressing MELS  Data collection activities primarily happens in the:  Emerging Technologies Programs  Codes and

  5. Students Innovate to Address Gas Shortages Following Hurricane Sandy |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Innovate to Address Gas Shortages Following Hurricane Sandy Students Innovate to Address Gas Shortages Following Hurricane Sandy November 9, 2012 - 3:43pm Addthis Franklin High School students working on their online map of gas and charging stations. | Photo courtesy Dayana Bustamante Franklin High School students working on their online map of gas and charging stations. | Photo courtesy Dayana Bustamante Ian Kalin Director of the Energy Data Initiative What are the key

  6. New partnership uses advanced computer science modeling to address climate

    National Nuclear Security Administration (NNSA)

    change | National Nuclear Security Administration | (NNSA) partnership uses advanced computer science modeling to address climate change Friday, August 29, 2014 - 10:26am Several national laboratories and institutions have joined forces to develop and apply the most complete climate and Earth system model to address the most challenging and demanding climate change issues. Accelerated Climate Modeling for Energy, or ACME, is designed to accelerate the development and application of fully

  7. Overexpression of miR-206 suppresses glycolysis, proliferation and migration in breast cancer cells via PFKFB3 targeting

    SciTech Connect

    Ge, Xin; Lyu, Pengwei; Cao, Zhang; Li, Jingruo; Guo, Guangcheng; Xia, Wanjun; Gu, Yuanting

    2015-08-07

    miRNAs, sorting as non-coding RNAs, are differentially expressed in breast tumor and act as tumor promoters or suppressors. miR-206 could suppress the progression of breast cancer, the mechanism of which remains unclear. The study here was aimed to investigate the effect of miR-206 on human breast cancers. We found that miR-206 was down-regulated while one of its predicted targets, 6-Phosphofructo-2-kinase (PFKFB3) was up-regulated in human breast carcinomas. 17β-estradiol dose-dependently decreased miR-206 expression as well as enhanced PFKFB3 mRNA and protein expression in estrogen receptor α (ERα) positive breast cancer cells. Furthermore, we identified that miR-206 directly interacted with 3′-untranslated region (UTR) of PFKFB3 mRNA. miR-206 modulated PFKFB3 expression in MCF-7, T47D and SUM159 cells, which was influenced by 17β-estradiol depending on ERα expression. In addition, miR-206 overexpression impeded fructose-2,6-bisphosphate (F2,6BP) production, diminished lactate generation and reduced cell proliferation and migration in breast cancer cells. In conclusion, our study demonstrated that miR-206 regulated PFKFB3 expression in breast cancer cells, thereby stunting glycolysis, cell proliferation and migration. - Highlights: • miR-206 was down-regulated and PFKFB3 was up-regulated in human breast carcinomas. • 17β-estradiol regulated miR-206 and PFKFB3 expression in ERα+ cancer cells. • miR-206directly interacted with 3′-UTR of PFKFB3 mRNA. • miR-206 fructose-2,6-bisphosphate (F2,6BP) impeded production and lactate generation. • miR-206 reduced cell proliferation and migration in breast cancer cells.

  8. AMENDMENT OF SOLICITATION/MODIFICATlON OF CONTRACT MI54 I See...

    National Nuclear Security Administration (NNSA)

    MI54 I See Block 16C I REQ. NO. Babcock & Wilcox Technical Services Pantex, LLC PO Box 30020 Amarillo, TX 79120 2. AMENDMENTIMODIFICATION NO. 1 3. EFFECTIVE DATE 1 4. ...

  9. File:USDA-CE-Production-GIFmaps-MI.pdf | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    MI.pdf Jump to: navigation, search File File history File usage Michigan Ethanol Plant Locations Size of this preview: 463 599 pixels. Other resolution: 464 600 pixels. Full...

  10. Simulations of neutron multiplicity measurements with MCNP-PoliMi.

    SciTech Connect

    Mattingly, John K.; Pozzi, Sara A.; Clarke, Shaun D.; Dennis, Ben D.; Miller, Eric C.

    2010-09-01

    The heightened focus on nuclear safeguards and accountability has increased the need to develop and verify simulation tools for modeling these applications. The ability to accurately simulate safeguards techniques, such as neutron multiplicity counting, aids in the design and development of future systems. This work focuses on validating the ability of the Monte Carlo code MCNPX-PoliMi to reproduce measured neutron multiplicity results for a highly multiplicative sample. The benchmark experiment for this validation consists of a 4.5-kg sphere of plutonium metal that was moderated by various thicknesses of polyethylene. The detector system was the nPod, which contains a bank of 15 3He detectors. Simulations of the experiments were compared to the actual measurements and several sources of potential bias in the simulation were evaluated. The analysis included the effects of detector dead time, source-detector distance, density, and adjustments made to the value of {nu}-bar in the data libraries. Based on this analysis it was observed that a 1.14% decrease in the evaluated value of {nu}-bar for 239Pu in the ENDF-VII library substantially improved the accuracy of the simulation.

  11. Climate Action Champions: Sault Ste. Marie Tribe of Chippewa Indians, MI |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Sault Ste. Marie Tribe of Chippewa Indians, MI Climate Action Champions: Sault Ste. Marie Tribe of Chippewa Indians, MI The Sault Ste. Marie Tribe of Chippewa Indians is a 44,000-strong federally recognized Indian tribe that is an economic, social and cultural force in its community across the eastern Upper Peninsula counties of Chippewa, Luce, Mackinac, Schoolcraft, Alger, Delta and Marquette, with housing and tribal centers, casinos, and other enterprises that employ

  12. Wind vs. Biofuels: Addressing Climate, Health and Energy

    SciTech Connect

    Professor Mark Jacobson

    2007-01-29

    The favored approach today for addressing global warming is to promote a variety of options: biofuels, wind, solar thermal, solar photovoltaic, geothermal, hydroelectric, and nuclear energy and to improve efficiency. However, by far, most emphasis has been on biofuels. It is shown here, though, that current-technology biofuels cannot address global warming and may slightly increase death and illness due to ozone-related air pollution. Future biofuels may theoretically slow global warming, but only temporarily and with the cost of increased air pollution mortality. In both cases, the land required renders biofuels an impractical solution. Recent measurements and statistical analyses of U.S. and world wind power carried out at Stanford University suggest that wind combined with other options can substantially address global warming, air pollution mortality, and energy needs simultaneously.

  13. Wind versus Biofuels for Addressing Climate, Health, and Energy

    SciTech Connect

    Jacobson, Mark Z.

    2007-01-29

    The favored approach today for addressing global warming is to promote a variety of options: biofuels, wind, solar thermal, solar photovoltaic, geothermal, hydroelectric, and nuclear energy and to improve efficiency. However, by far, most emphasis has been on biofuels. It is shown here, though, that current-technology biofuels cannot address global warming and may slightly increase death and illness due to ozone-related air pollution. Future biofuels may theoretically slow global warming, but only temporarily and with the cost of increased air pollution mortality. In both cases, the land required renders biofuels an impractical solution. Recent measurements and statistical analyses of U.S. and world wind power carried out at Stanford University suggest that wind combined with other options can substantially address global warming, air pollution mortality, and energy needs simultaneously.

  14. Mailing Addresses and Information Numbers for Operations, Field, and Site

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Offices | Department of Energy About Energy.gov » Mailing Addresses and Information Numbers for Operations, Field, and Site Offices Mailing Addresses and Information Numbers for Operations, Field, and Site Offices Name Telephone Number U.S. Department of Energy Ames Site Office 111 TASF, Iowa State University Ames, Iowa 50011 515-294-9557 U.S. Department of Energy Argonne Site Office 9800 S. Cass Avenue Argonne, IL 60439 630-252-2000 U.S. Department of Energy Berkeley Site Office Berkeley

  15. Buckland Students Explore Ways to Address Rural Alaska Energy Challenges |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Buckland Students Explore Ways to Address Rural Alaska Energy Challenges Buckland Students Explore Ways to Address Rural Alaska Energy Challenges May 23, 2016 - 6:03pm Addthis Students pose in front of Buckland’s 10.53-kW solar system used to power the village’s new water plant. Photo from Alison Jech, Buckland School. Students pose in front of Buckland's 10.53-kW solar system used to power the village's new water plant. Photo from Alison Jech, Buckland School.

  16. Results of the radiological survey at 5 Hancock Street, Lodi, New Jersey (LJ029)

    SciTech Connect

    Cottrell, W.D.; Floyd, L.M.; Francis, M.W.; Mynatt, J.O.

    1989-09-01

    Maywood Chemical Works (MCW) of Maywood, New Jersey, generated process wastes and residues associated with the production and refining of thorium and thorium compounds from monazite ores from 1916 to 1956. MCW supplied rare earth metals and thorium compounds to the Atomic Energy Commission and various other government agencies from the late 1940s to the mid-1950s. Area residents used the sandlike waste from this thorium extraction process mixed with tea and cocoa leaves as mulch in their yards. Some of these contaminated wastes were also eroded from the site into Lodi Brook. At the request of the US Department of Energy (DOE), a group from Oak Ridge National Laboratory conducts investigative radiological surveys of properties in the vicinity of MCW to determine whether a property is contaminated with radioactive residues, principally {sup 232}Th, derived from the MCW site. The survey typically includes direct measurement of gamma radiation levels and soil sampling for radionuclide analyses. The survey of this site, 5 Hancock Street, Lodi, New Jersey (LJ029), was conducted during 1985 and 1986. Results of the survey demonstrated concentrations in excess of the DOE Formerly Utilized Sites Remedial Action Program criteria. The radionuclide distributions are typical of the type of the material originating from the MCW site. 5 refs., 6 figs., 3 tabs.

  17. Results of the radiological survey at 205 Main Street, Lodi, New Jersey (LJ075)

    SciTech Connect

    Foley, R.D.; Carrier, R.F.; Floyd, L.M.; Crutcher, J.W.

    1989-08-01

    Maywood Chemical Works (MCW) of Maywood, New Jersey, generated process wastes and residues associated with the production and refining of thorium and thorium compounds from monazite ores from 1916 to 1956. MCW supplied rare earth metals and thorium compounds to the Atomic Energy Commission and various other government agencies from the late 1940s to the mid-1950s. Area residents used the sandlike waste from this thorium extraction process mixed with tea and cocoa leaves as mulch in their yards. Some of these contaminated wastes were also eroded from the site into Lodi Brook. At the request of the US Department of Energy (DOE), a group from Oak Ridge National Laboratory conducts investigative radiological surveys of properties in the vicinity of MCW to determine whether a property is contaminated with radioactive residues, principally /sup 232/Th, derived from the MCW site. The survey typically includes direct measurement of gamma radiation levels and soil sampling for radionuclide analyses. The survey of this site, 205 Main Street, Lodi, New Jersey (LJ075), was conducted during 1987 and 1988. Results of the survey indicated radioactivity in the range of normal background for the northern New Jersey area. Radiological assessments of soil samples from the site demonstrate no radionuclide concentrations in excess of DOE Formerly Utilized Sites Remedial Action Program criteria. 5 refs., 21 figs., 3 tabs.

  18. Results of the radiological survey at 15 John Street, Lodi, New Jersey (LJ087)

    SciTech Connect

    Foley, R.D.; Floyd, L.M.

    1989-12-01

    Maywood Chemical Works (MCW) of Maywood, New Jersey, generated process wastes and residues associated with the production and refining of thorium and thorium compounds from monazite ores from 1916 to 1956. MCW supplied rare earth metals and thorium compounds to the Atomic Energy Commission and various other government agencies from the late 1940s to the mid-1950s. Area residents used the sandlike waste from this thorium extraction process mixed with tea and cocoa leaves as mulch in their yards. Some of these contaminated wastes were also eroded from the site into Lodi Brook. At the request of the US Department of Energy (DOE), a group from Oak Ridge National Laboratory conducts investigative radiological surveys of properties in the vicinity of MCW to determine whether a property is contaminated with radioactive residues, principally {sup 232}Th, derived from the MCW site. The survey typically includes direct measurement of gamma radiation levels and soil sampling for radionuclide analyses. The survey of this site, 15 John Street, Lodi, New Jersey (LJ087), was conducted during 1988. 5 refs., 3 figs., 3 tabs.

  19. Results of the radiological survey at 77 Sinninger Street, Maywood, New Jersey (MJ052)

    SciTech Connect

    Foley, R.D.; Brown, K.S.

    1993-06-01

    Maywood Chemical Works (MCW) of Maywood, New Jersey, generated process wastes and residues associated with the production and refining of thorium and thorium compounds from monazite ores from 1916 to 1956. MCW supplied rare earth metals and thorium compounds to the Atomic Energy Commission and various other government agencies from the late 1940s to the mid-1950s. Area residents used the sandlike waste from this thorium extraction process mixed with tea and cocoa leaves as mulch in their yards. Some of these contaminated wastes were also eroded from the site into Lodi Brook. At the request of the US Department of Energy (DOE), a group from Oak Ridge National Laboratory conducts investigative radiological surveys of properties in the vicinity of MCW to determine whether a property is contaminated with radioactive residues, principally {sup 232}Th, derived from the MCW site. The survey typically includes direct measurement of gamma radiation levels and soil sampling for radionuclide analyses. The survey of this site, 77 Sinninger Street, Maywood, New Jersey (MJ052), was conducted on December 17, 1992. Results of the survey demonstrated no radionuclide concentrations in excess of the DOE Formerly Utilized Sites Remedial Action Program criteria. The radionuclide distributions were not significantly different from normal background levels in the northern New Jersey area.

  20. Results of the radiological survey at 9 Hancock Street, Lodi, New Jersey (LJ028)

    SciTech Connect

    Cottrell, W.D.; Floyd, L.M.; Francis, M.W.; Mynatt, J.O.

    1989-09-01

    Maywood Chemical Works (MCW) of Maywood, New Jersey, generated process wastes and residues associated with the production and refining of thorium and thorium compounds from monazite ores from 1916 to 1956. MCW supplied rare earth metals and thorium compounds to the Atomic Energy Commission and various other government agencies from the late 1940s to the mid-1950s. Area residents used the sandlike waste from this thorium extraction process mixed with tea and cocoa leaves as mulch in their yards. Some of these contaminated wastes were also eroded from the site into Lodi Brook. At the request of the US Department of Energy (DOE), a group from Oak Ridge National Laboratory conducts investigative radiological surveys of properties in the vicinity of MCW to determine whether a property is contaminated with radioactive residues, principally {sup 232}Th, derived from the MCW site. The survey typically includes direct measurement of gamma radiation levels and soil sampling for radionuclide analyses. The survey of this site, 9 Hancock Street, Lodi, New Jersey (LJ028), was conducted during 1985 and 1986. Some radionuclide measurements were greater than typical background levels in the northern New Jersey area. However, results of the survey demonstrated no radionuclide concentrations in excess of the DOE Formerly Utilized Sites Remedial Action Program criteria. 5 refs., 6 figs., 3 tabs.

  1. Results of the radiological survey at 17 John Street, Lodi, New Jersey

    SciTech Connect

    Foley, R.D.; Floyd, L.M.

    1989-12-01

    Maywood Chemical Works (MCW) of Maywood, New Jersey, generated process wastes and residues associated with the production and refining of thorium and thorium compounds from monazite ores from 1916 to 1956. MCW supplied rare earth metals and thorium compounds to the Atomic Energy Commission and various other government agencies from the late 1940s to the mid-1950s. Area residents used the sandlike waste from this thorium extraction process mixed with tea and cocoa leaves as mulch in their yards. Some of these contaminated wastes were also eroded from the site into Lodi Brook. At the request of the US Department of Energy (DOE), a group from Oak Ridge National Laboratory conducts investigative radiological surveys of properties in the vicinity of MCW to determine whether a property is contaminated with radioactive residues, principally {sup 232}Th, derived from the MCW site. The survey typically includes direct measurement of gamma radiation levels and soil sampling for radionuclide analyses. The survey of this site, 17 John Street, Lodi, New Jersey (LJ088), was conducted during 1988. 5 refs., 2 figs., 3 tabs.

  2. Results of the radiological survey at 7 Hancock Street, Lodi, New Jersey (LJ027)

    SciTech Connect

    Cottrell, W.D.; Floyd, L.M.; Francis, M.W.; Mynatt, J.O.

    1989-09-01

    Maywood Chemical Works (MCW) of Maywood, New Jersey, generated process wastes and residues associated with the production and refining of thorium and thorium compounds from monazite ores from 1916 to 1956. MCW supplied rare earth metals and thorium compounds to the Atomic Energy Commission and various other government agencies from the late 1940s to the mid-1950s. Area residents used the sandlike waste from this thorium extraction process mixed with tea and cocoa leaves as mulch in their yards. Some of these contaminated wastes were also eroded from the site into Lodi Brook. AT the request of the US Department of Energy (DOE), a group from Oak Ridge National Laboratory conducts investigative radiological surveys of properties in the vicinity of MCW to determine whether a property is contaminated with radioactive residues, principally {sup 232}Th, derived from the MCW site. The survey typically includes direct measurement of gamma radiation levels and soil sampling for radionuclide analyses. The survey of this site, 7 Hancock Street, Lodi, New Jersey (LJ027), was conducted during 1985 and 1986. Results of the survey demonstrated radionuclide concentrations in excess of the DOE Formerly Utilized Sites Remedial Action Program criteria. The radionuclide distributions are typical of the type of material originating from the MCW site. 5 refs., 5 figs., 3 tabs.

  3. Argonne Director Eric Isaacs addresses the National Press Club

    ScienceCinema

    Eric Isaccs

    2016-07-12

    Argonne Director Eric Isaacs addresses the National Press Club on 9/15/2009. To build a national economy based on sustainable energy, the nation must first "reignite its innovation ecology," he said. Issacs makes the case for investing in science to secure America's future.

  4. miR-196a targets netrin 4 and regulates cell proliferation and migration of cervical cancer cells

    SciTech Connect

    Zhang, Jie; Zheng, Fangxia; Yu, Gang; Yin, Yanhua; Lu, Qingyang

    2013-11-01

    Highlights: miR-196a was overexpressed in cervical cancer tissue compared to normal tissue. miR-196a expression elevated proliferation and migration of cervical cancer cells. miR-196a inhibited NTN4 expression by binding 3?-UTR region of NTN4 mRNA. NTN4 inversely correlated with miR-196a expression in cervical tissue and cell line. NTN4 expression was low in cervical cancer tissue compared to normal tissue. -- Abstract: Recent research has uncovered tumor-suppressive and oncogenic potential of miR-196a in various tumors. However, the expression and mechanism of its function in cervical cancer remains unclear. In this study, we assess relative expression of miR-196a in cervical premalignant lesions, cervical cancer tissues, and four cancer cell lines using quantitative real-time PCR. CaSki and HeLa cells were treated with miR-196a inhibitors, mimics, or pCDNA/miR-196a to investigate the role of miR-196a in cancer cell proliferation and migration. We demonstrated that miR-196a was overexpressed in cervical intraepithelial neoplasia 23 and cervical cancer tissue. Moreover, its expression contributes to the proliferation and migration of cervical cancer cells, whereas inhibiting its expression led to a reduction in proliferation and migration. Five candidate targets of miR-196a chosen by computational prediction and Cervical Cancer Gene Database search were measured for their mRNA in both miR-196a-overexpressing and -depleted cancer cells. Only netrin 4 (NTN4) expression displayed an inverse association with miR-196a. Fluorescent reporter assays revealed that miR-196a inhibited NTN4 expression by targeting one binding site in the 3?-untranslated region (3?-UTR) of NTN4 mRNA. Furthermore, qPCR and Western blot assays verified NTN4 expression was downregulated in cervical cancer tissues compared to normal controls, and in vivo mRNA level of NTN4 inversely correlated with miR-196a expression. In summary, our findings provide new insights about the functional role of

  5. <mi>B> -meson decay constants from 2+1 -flavor lattice QCD with domain-wall light quarks and relativistic heavy quarks

    SciTech Connect

    Christ, N. H.; Flynn, J. M.; Izubuchi, T.; Kawanai, T.; Lehner, C.; Soni, A.; Van de Water, R. S.; Witzel, O.

    2015-03-01

    We calculate the mi>Bmi>-meson decay constants mi>fmi>mi>Bmi>, mi>fmi>mi>Bmi>mi>smi>, and their ratio in unquenched lattice QCD using domain-wall light quarks and relativistic mi>b> quarks. We use gauge-field ensembles generated by the RBC and UKQCD collaborations using the domain-wall fermion action and Iwasaki gauge action with three flavors of light dynamical quarks. We analyze data at two lattice spacings of mi>ami>0.11, 0.086 fm with unitary pion masses as light as mi>Mmi>mi>πmi>290mi>MeV>; this enables us to control the extrapolation to the physical light-quark masses and continuum. For the mi>b> quarks we use the anisotropic clover action with the relativistic heavy-quark interpretation, such that discretization errors from the heavy-quark action are of the same size as from the light-quark sector. We renormalize the

  6. miR-214 promotes the proliferation and invasion of osteosarcoma cells through direct suppression of LZTS1

    SciTech Connect

    Xu, Zhengyu; Wang, Tao

    2014-06-27

    Highlights: • miR-214 is upregulated in human OS tissues and inversely correlated with LZTS1 expression. • miR-214 directly targets LZTS1 by binding to its 3′-UTR. • miR-214 promotes OS cell proliferation, invasion and tumor growth. • Overexpression of LZTS1 reverses miR-214-induced proliferation and invasion of OS cells. - Abstract: Previous studies have shown that miR-214 functions either as an oncogene or a tumor suppressor in various human cancer types. The role of this microRNA in osteosarcoma (OS) is presently unclear. Here, we demonstrated that miR-214 is frequently upregulated in OS specimens, compared with noncancerous bone tissues. Bioinformatics analysis further revealed leucine zipper, putative tumor suppressor 1 (LZTS1) as a potential target of miR-214. Expression patterns of miR-214 were inversely correlated with those of LZTS1 mRNA and protein in OS tissues. Data from reporter assays showed that miR-214 directly binds to the 3′-untranslated region (3′-UTR) of LZTS1 mRNA and suppresses expression at both transcriptional and translational levels. In functional assays, miR-214 promoted OS cell proliferation, invasion and tumor growth in nude mice, which could be reversed by overexpression of LZTS1. Taken together, our data provide compelling evidence that miR-214 functions as an onco-miRNA in OS, and its oncogenic effects are mediated chiefly through downregulation of LZTS1.

  7. MiR-132 prohibits proliferation, invasion, migration, and metastasis in breast cancer by targeting HN1

    SciTech Connect

    Zhang, Zhan-Guo Chen, Wei-Xun Wu, Yan-Hui Liang, Hui-Fang Zhang, Bi-Xiang

    2014-11-07

    Highlights: • MiR-132 is down-regulated in breast cancer tissues and cell lines. • MiR-132 directly regulates HN1 by binding its 3′ UTR. • MiR-132 shows regulatory role in proliferation, invasion, migration and metastasis. • HN1 is involved in miR-132-mediated cell behavior. • Aberrant HN1 is associated with worse overall survival of breast cancer patients. - Abstract: Accumulating evidence indicates that miRNAs play critical roles in tumorigenesis and cancer progression. This study aims to investigate the role and the underlying mechanism of miR-132 in breast cancer. Here, we report that miR-132 is significantly down-regulated in breast cancer tissues and cancer cell lines. Additional study identifies HN1 as a novel direct target of miR-132. MiR-132 down-regulates HN1 expression by binding to the 3′ UTR of HN1 transcript, thereby, suppressing multiple oncogenic traits such as cancer cell proliferation, invasion, migration and metastasis in vivo and in vitro. Overexpression of HN1 restores miR-132-suppressed malignancy. Importantly, higher HN1 expression is significantly associated with worse overall survival of breast cancer patients. Taken together, our data demonstrate a critical role of miR-132 in prohibiting cell proliferation, invasion, migration and metastasis in breast cancer through direct suppression of HN1, supporting the potential utility of miR-132 as a novel therapeutic strategy against breast cancer.

  8. Plan for addressing issues relating to oil shale plant siting

    SciTech Connect

    Noridin, J. S.; Donovan, R.; Trudell, L.; Dean, J.; Blevins, A.; Harrington, L. W.; James, R.; Berdan, G.

    1987-09-01

    The Western Research Institute plan for addressing oil shale plant siting methodology calls for identifying the available resources such as oil shale, water, topography and transportation, and human resources. Restrictions on development are addressed: land ownership, land use, water rights, environment, socioeconomics, culture, health and safety, and other institutional restrictions. Descriptions of the technologies for development of oil shale resources are included. The impacts of oil shale development on the environment, socioeconomic structure, water availability, and other conditions are discussed. Finally, the Western Research Institute plan proposes to integrate these topics to develop a flow chart for oil shale plant siting. Western Research Institute has (1) identified relative topics for shale oil plant siting, (2) surveyed both published and unpublished information, and (3) identified data gaps and research needs. 910 refs., 3 figs., 30 tabs.

  9. Agenda: Enhancing Energy Infrastructure Resiliency and Addressing Vulnerabilities

    Energy.gov [DOE]

    Quadrennial Energy Review Task Force Secretariat and Energy Policy and Systems Analysis Staff, U. S. Department of Energy (DOE) Public Meeting on “Enhancing Resilience in Energy Infrastructure and Addressing Vulnerabilities” On Friday, April 11, 2014, at 10 a.m. in room HVC-215 of the U.S. Capitol, the Department of Energy (DOE), acting as the Secretariat for the Quadrennial Energy Review Task Force, will hold a public meeting to discuss and receive comments on issues related to the Quadrennial Energy Review (QER). The meeting will focus on infrastructure vulnerabilities related to the electricity, natural gas and petroleum transmission, storage and distribution systems (TS&D). The meeting will consist of two facilitated panels of experts on identifying and addressing vulnerabilities within the nation’s energy TS&D infrastructure. Following the panels, an opportunity will be provided for public comment via an open microphone session.

  10. Briefing Memo: Enhancing Resilience in Energy Infrastructure and Addressing Vulnerabilities

    Office of Energy Efficiency and Renewable Energy (EERE)

    Quadrennial Energy Review Task Force Secretariat and Energy Policy and Systems Analysis Staff, U. S. Department of Energy Public Meeting on “Enhancing Resilience in Energy Infrastructure and Addressing Vulnerabilities” On Friday, April 11, 2014, at 10 a.m. in room HVC-215 of the U.S. Capitol, the Department of Energy (DOE), acting as the Secretariat for the Quadrennial Energy Review Task Force, will hold a public meeting to discuss and receive comments on issues related to the Quadrennial Energy Review (QER). The meeting will focus on infrastructure vulnerabilities related to the electricity, natural gas and petroleum transmission, storage and distribution systems (TS&D). The meeting will consist of two facilitated panels of experts on identifying and addressing vulnerabilities within the nation’s energy TS&D infrastructure. Following the panels, an opportunity will be provided for public comment via an open microphone session.

  11. miR-421 induces cell proliferation and apoptosis resistance in human nasopharyngeal carcinoma via downregulation of FOXO4

    SciTech Connect

    Chen, Liang; Department of Otolaryngology, Guangzhou General Hospital of PLA Guangzhou Command, Guangzhou 510010 ; Tang, Yanping; Wang, Jian; Yan, Zhongjie; Xu, Ruxiang

    2013-06-14

    Highlights: •miR-421 is upregulated in nasopharyngeal carcinoma. •miR-421 induces cell proliferation and apoptosis resistance. •FOXO4 is a direct and functional target of miR-421. -- Abstract: microRNAs have been demonstrated to play important roles in cancer development and progression. Hence, identifying functional microRNAs and better understanding of the underlying molecular mechanisms would provide new clues for the development of targeted cancer therapies. Herein, we reported that a microRNA, miR-421 played an oncogenic role in nasopharyngeal carcinoma. Upregulation of miR-421 induced, whereas inhibition of miR-421 repressed cell proliferation and apoptosis resistance. Furthermore, we found that upregulation of miR-421 inhibited forkhead box protein O4 (FOXO4) signaling pathway following downregulation of p21, p27, Bim and FASL expression by directly targeting FOXO4 3′UTR. Additionally, we demonstrated that FOXO4 expression is critical for miR-421-induced cell growth and apoptosis resistance. Taken together, our findings not only suggest that miR-421 promotes nasopharyngeal carcinoma cell proliferation and anti-apoptosis, but also uncover a novel regulatory mechanism for inactivation of FOXO4 in nasopharyngeal carcinoma.

  12. Energy Saver RSS Subscribers: Update Your Feed Address | Department of

    Energy Saver

    Department of Energy Customer Service Plan Department of Energy Customer Service Plan The U.S. Department of Energy (DOE) strives to ensure America's security and prosperity by addressing its energy, environmental, and nuclear challenges through transformative science and technology solutions. Through this work, the Department serves a range of internal and external customers including DOE's employee and contractor workforce, students, scientists and researchers, businesses and other branches of

  13. Secretary Bodman Addresses Turkmenistan Industrial Oil and Gas Exhibition |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Turkmenistan Industrial Oil and Gas Exhibition Secretary Bodman Addresses Turkmenistan Industrial Oil and Gas Exhibition November 16, 2007 - 4:31pm Addthis Holds Bilateral Discussion with President of Turkmenistan on Opening of Markets, Increased Investment, and Multiple Trade Routes ASHGABAT, TURKMENISTAN - U.S. Secretary of Energy Samuel W. Bodman today held bilateral energy discussions with the President of Turkmenistan and other senior Turkmenistan officials and

  14. Smart Grid RFI: Addressing Policy and Logistical Challenges, Comments from

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    the Edison Electric Institute | Department of Energy Challenges, Comments from the Edison Electric Institute Smart Grid RFI: Addressing Policy and Logistical Challenges, Comments from the Edison Electric Institute The Edison Electric Institute ("EEI"), on behalf of its member companies, hereby submits the following comments in response to the request by the Department of Energy ("DOE" or "Department") for information on a wide range of issues dealing with Smart

  15. Smart Grid RFI: Addressing Policy and Logistical Challenges. Comments of

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    the Alliance to Save Energy. | Department of Energy Challenges. Comments of the Alliance to Save Energy. Smart Grid RFI: Addressing Policy and Logistical Challenges. Comments of the Alliance to Save Energy. The Alliance to Save Energy is a coalition of prominent business, government, environmental, and consumer leaders who promote the efficient use of energy worldwide to benefit consumers, the environment, economy, and national security. The Alliance to Save Energy (the Alliance) thanks the

  16. Community Leaders to Address Energy Solutions Through Leadership Program -

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    News Releases | NREL Community Leaders to Address Energy Solutions Through Leadership Program May 16, 2007 Thirteen local community leaders were chosen to join the U.S. Department of Energy's (DOE) National Renewable Energy Laboratory's (NREL) Executive Energy Leadership program. Energy Execs will participate in monthly educational sessions covering topics such as solar technology, wind energy and transportation of the future. Sessions will include an in depth look at future markets and

  17. Technology Transfer Sustaining Our Legacy of Addressing National Challenges

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Technology Transfer Sustaining Our Legacy of Addressing National Challenges 2007-2008 Progress Report Credits Writing: Shandra Clow, Steven Girrens, David Holmes, Marjorie Mascheroni, Duncan McBranch, John Mott, Mig Owens, Belinda Padilla, Tatjana Rosev, John Russell, and Steve Stringer Editing: Marjorie Mascheroni Design: Kathi G. Parker Printing Coordination: Guadalupe Archuleta www.lanl.gov/partnerships Los Alamos National Laboratory, an affirmative action/equal opportunity employer, is

  18. Addressing Policy and Logistical Challenges to Smart Grid Implementation:

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Comments by the Office of the Ohio Consumers' Counsel | Department of Energy Smart Grid Implementation: Comments by the Office of the Ohio Consumers' Counsel Addressing Policy and Logistical Challenges to Smart Grid Implementation: Comments by the Office of the Ohio Consumers' Counsel The Office of the Ohio Consumers' Counsel ("OCC") hereby submits the following comments in response to the United States Department of Energy ("DOE") Request for Information

  19. Addressing Policy and Logistical Challenges to Smart Grid Implementation:

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Federal Register Notice Volume 75, No. 180 - Sep. 17, 2010 | Department of Energy Smart Grid Implementation: Federal Register Notice Volume 75, No. 180 - Sep. 17, 2010 Addressing Policy and Logistical Challenges to Smart Grid Implementation: Federal Register Notice Volume 75, No. 180 - Sep. 17, 2010 The Department of Energy (DOE) is seeking comments from interested parties on policy and logistical challenges that confront smart grid implementation, as well as recommendations on how to best

  20. Addressing Policy and Logistical Challenges to smart grid Implementation:

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    eMeter Response to Department of Energy RFI | Department of Energy smart grid Implementation: eMeter Response to Department of Energy RFI Addressing Policy and Logistical Challenges to smart grid Implementation: eMeter Response to Department of Energy RFI eMeter is a smart grid software company that provides smart network application platform (SNAP) software to integrate smart meters and smart grid communications networks and devices with utility IT systems. eMeter also provides smart grid

  1. Smart Grid RFI: Addressing Policy and Logistical Challenges

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Electricity Delivery and Energy Reliability 1000 Independence Avenue, SW Room 8H033 Washington, DC 20585 Submitted electronically via smartgridpolicy@hq.doe.gov Smart Grid Request for Information: Addressing Policy and Logistical Challenges Comments of the Alliance to Save Energy The Alliance to Save Energy (the Alliance) thanks the Department of Energy for the opportunity to comment on broad issues of policy and logistical challenges faced in smart grid implementation. The Alliance to Save

  2. Energy Department Addresses Largest Gathering of Geothermal Energy Stakeholders

    Energy.gov [DOE]

    U.S. Department of Energy investments are tapping a vast resource of clean, baseload energy from the earth's heat, according to Douglas Hollett, Program Manager for the Department's Geothermal Technologies Office. Hollett addressed over 1,000 this week at the annual conference of the Geothermal Resources Council (GRC) in Reno, Nevadathe industry's largest annual gathering of geothermal energy stakeholders in the nation.

  3. UK Energy Minister to Address World Renewable Energy Congress - News

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Releases | NREL UK Energy Minister to Address World Renewable Energy Congress Conference, Expo to Bring International 'Clean Energy' experts to Denver April 7, 2004 Golden, Colo. - Stephen Timms, energy minister for the United Kingdom will speak to delegates from as many as 100 nations at the opening ceremony of the eighth World Renewable Energy Congress (WREC VIII) in Denver on Aug. 30. Expected to be the world's largest gathering of renewable energy experts, WREC VIII will provide a forum

  4. Symbiosis: Addressing Biomass Production Challenges and Climate Change

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Symbiosis: Addressing Biomass Production Challenges and Climate Change Cyd E. Hamilton, PhD American Association for Advancement of Science Fellow Symbiosis Conference, Cornell University 2013 2 | Bioenergy Technologies Office Outline * Thank you! - John Ferrell and Valerie Reed (BETO) - James White (Rutgers) - Stacey Young (Sentech) * Background Motivation * Conference Objectives - Two days - Long term (Bioenergy Tech. Office Report) - Articles e.g., reviews, commentaries * Plenary Speaker

  5. NEW APPROACH TO ADDRESSING GAS GENERATION IN RADIOACTIVE MATERIAL PACKAGING

    SciTech Connect

    Watkins, R; Leduc, D; Askew, N

    2009-06-25

    Safety Analysis Reports for Packaging (SARP) document why the transportation of radioactive material is safe in Type A(F) and Type B shipping containers. The content evaluation of certain actinide materials require that the gas generation characteristics be addressed. Most packages used to transport actinides impose extremely restrictive limits on moisture content and oxide stabilization to control or prevent flammable gas generation. These requirements prevent some users from using a shipping container even though the material to be shipped is fully compliant with the remaining content envelope including isotopic distribution. To avoid these restrictions, gas generation issues have to be addressed on a case by case basis rather than a one size fits all approach. In addition, SARP applicants and review groups may not have the knowledge and experience with actinide chemistry and other factors affecting gas generation, which facility experts in actinide material processing have obtained in the last sixty years. This paper will address a proposal to create a Gas Generation Evaluation Committee to evaluate gas generation issues associated with Safety Analysis Reports for Packaging material contents. The committee charter could include reviews of both SARP approved contents and new contents not previously evaluated in a SARP.

  6. Supplementary radiological and beryllium characterization of the facility at 425 Peek Street, Schenectady, New York

    SciTech Connect

    Foley, R.D.; Allred, J.F.; Carrier, R.F.

    1994-10-01

    At the request of the Office of Naval Reactors through the Office of Remedial Action and Waste Technology, a radiological survey of the Peek Street industrial facility, the adjacent state-owned bike path, and two nearby residential properties was conducted by Oak Ridge National Laboratory (ORNL) in November 1989. The results indicated small isolated areas that exceeded DOE guidelines. These areas totaled approximately 0.2 m{sup 2} of floor area and approximately 3 m{sup 2} of wall area inside the building, and two small areas totaling approximately 5 m{sup 2} outside the building. A small section of one of these areas extended beyond the fence on the east side of the industrial property onto the state-owned property. No residual radioactive material or elevated radiation levels were detected on any portion of the paved section of the bike path or the residential properties adjacent to the site. Because the elevated radiation levels were localized and limited in extent, any credible use scenario, including current use conditions, indicated that no significant radiation exposures would accrue to individuals frequenting the area. Samples were also analyzed for elemental beryllium since that material had formerly been used at the site. In conjunction with the planned remediation at the facility, a supplementary characterization survey was performed to further define the areas containing beryllium in excess of the identified guidelines. Additional radiological characterization of Ra-226, Th-232, and U-238 was also performed in areas that were largely inaccessible prior to the remediation efforts.

  7. Roles of miRNAs in microcystin-LR-induced Sertoli cell toxicity

    SciTech Connect

    Zhou, Yuan; Wang, Hui; Wang, Cong; Qiu, Xuefeng; Benson, Mikael; Yin, Xiaoqin; Xiang, Zou; Li, Dongmei; and others

    2015-08-15

    Microcystin (MC)-LR, a cyclic heptapeptide, is a potent reproductive system toxin. To understand the molecular mechanisms of MC-induced reproductive system cytotoxicity, we evaluated global changes of miRNA and mRNA expression in mouse Sertoli cells following MC-LR treatment. Our results revealed that the exposure to MC-LR resulted in an altered miRNA expression profile that might be responsible for the modulation of mRNA expression. Bio-functional analysis indicated that the altered genes were involved in specific cellular processes, including cell death and proliferation. Target gene analysis suggested that junction injury in Sertoli cells exposed to MC-LR might be mediated by miRNAs through the regulation of the Sertoli cell-Sertoli cell pathway. Collectively, these findings may enhance our understanding on the modes of action of MC-LR on mouse Sertoli cells as well as the molecular mechanisms underlying the toxicity of MC-LR on the male reproductive system. - Highlights: • miRNAs were altered in Sertoli cells exposed to MC-LR. • Alerted genes were involved in different cell functions including the cell morphology. • MC-LR adversely affected Sertoli cell junction formation through the regulating miRNAs.

  8. Ionizing Radiation–Inducible miR-27b Suppresses Leukemia Proliferation via Targeting Cyclin A2

    SciTech Connect

    Wang, Bo; Li, Dongping; Kovalchuk, Anna; Litvinov, Dmitry; Kovalchuk, Olga

    2014-09-01

    Purpose: Ionizing radiation is a common carcinogen that is important for the development of leukemia. However, the underlying epigenetic mechanisms remain largely unknown. The goal of the study was to explore microRNAome alterations induced by ionizing radiation (IR) in murine thymus, and to determine the role of IR-inducible microRNA (miRNA/miR) in the development of leukemia. Methods and Materials: We used the well-established C57BL/6 mouse model and miRNA microarray profiling to identify miRNAs that are differentially expressed in murine thymus in response to irradiation. TIB152 human leukemia cell line was used to determine the role of estrogen receptor–α (ERα) in miR-27b transcription. The biological effects of ectopic miR-27b on leukemogenesis were measured by western immunoblotting, cell viability, apoptosis, and cell cycle analyses. Results: Here, we have shown that IR triggers the differential expression of miR-27b in murine thymus tissue in a dose-, time- and sex-dependent manner. miR-27b was significantly down-regulated in leukemia cell lines CCL119 and TIB152. Interestingly, ERα was overexpressed in those 2 cell lines, and it was inversely correlated with miR-27b expression. Therefore, we used TIB152 as a model system to determine the role of ERα in miR-27b expression and the contribution of miR-27b to leukemogenesis. β-Estradiol caused a rapid and transient reduction in miR-27b expression reversed by either ERα-neutralizing antibody or ERK1/2 inhibitor. Ectopic expression of miR-27b remarkably suppressed TIB152 cell proliferation, at least in part, by inducing S-phase arrest. In addition, it attenuated the expression of cyclin A2, although it had no effect on the levels of PCNA, PPARγ, CDK2, p21, p27, p-p53, and cleaved caspase-3. Conclusion: Our data reveal that β-estradiol/ERα signaling may contribute to the down-regulation of miR-27b in acute leukemia cell lines through the ERK1/2 pathway, and that miR-27b may function as a tumor

  9. Curcumin inhibits oral squamous cell carcinoma SCC-9 cells proliferation by regulating miR-9 expression

    SciTech Connect

    Xiao, Can; Wang, Lili; Zhu, Lifang; Zhang, Chenping; Zhou, Jianhua

    2014-11-28

    Highlights: • miR-9 expression level was significantly decreased in OSCC tissues. • Curcumin significantly inhibited SCC-9 cells proliferation. • miR-9 mediates the inhibition of SCC-9 proliferation by curcumin. • Curcumin suppresses Wnt/β-catenin signaling in SCC-9 cells. • miR-9 mediates the suppression of Wnt/β-catenin signaling by curcumin. - Abstract: Curcumin, a phytochemical derived from the rhizome of Curcuma longa, has shown anticancer effects against a variety of tumors. In the present study, we investigated the effects of curcumin on the miR-9 expression in oral squamous cell carcinoma (OSCC) and explored the potential relationships between miR-9 and Wnt/β-catenin pathway in curcumin-mediated OSCC inhibition in vitro. As the results shown, the expression levels of miR-9 were significantly lower in clinical OSCC specimens than those in the adjacent non-tumor tissues. Furthermore, our results indicated that curcumin inhibited OSCC cells (SCC-9 cells) proliferation through up-regulating miR-9 expression, and suppressing Wnt/β-catenin signaling by increasing the expression levels of the GSK-3β, phosphorylated GSK-3β and β-catenin, and decreasing the cyclin D1 level. Additionally, the up-regulation of miR-9 by curcumin in SCC-9 cells was significantly inhibited by delivering anti-miR-9 but not control oligonucleotides. Downregulation of miR-9 by anti-miR-9 not only attenuated the growth-suppressive effects of curcumin on SCC-9 cells, but also re-activated Wnt/β-catenin signaling that was inhibited by curcumin. Therefore, our findings would provide a new insight into the use of curcumin against OSCC in future.

  10. miR-339-5p inhibits alcohol-induced brain inflammation through regulating NF-κB pathway

    SciTech Connect

    Zhang, Yu; Wei, Guangkuan; Di, Zhiyong; Zhao, Qingjie

    2014-09-26

    Graphical abstract: - Highlights: • Alcohol upregulates miR-339-5p expression. • miR-339-5p inhibits the NF-kB pathway. • miR-339-5p interacts with and blocks activity of IKK-beat and IKK-epsilon. • miR-339-5p modulates IL-1β, IL-6 and TNF-α. - Abstract: Alcohol-induced neuroinflammation is mediated by the innate immunesystem. Pro-inflammatory responses to alcohol are modulated by miRNAs. The miRNA miR-339-5p has previously been found to be upregulated in alcohol-induced neuroinflammation. However, little has been elucidated on the regulatory functions of this miRNA in alcohol-induced neuroinflammation. We investigated the function of miR-339-5p in alcohol exposed brain tissue and isolated microglial cells using ex vivo and in vitro techniques. Our results show that alcohol induces transcription of miR 339-5p, IL-6, IL-1β and TNF-α in mouse brain tissue and isolated microglial cells by activating NF-κB. Alcohol activation of NF-κB allows for nuclear translocation of the NF-κB subunit p65 and expression of pro-inflammatory mediators. miR-339-5p inhibited expression of these pro-inflammatory factors through the NF-κB pathway by abolishing IKK-β and IKK-ε activity.

  11. miR-208-3p promotes hepatocellular carcinoma cell proliferation and invasion through regulating ARID2 expression

    SciTech Connect

    Yu, Peng; Wu, Dingguo; You, Yu; Sun, Jing; Lu, Lele; Tan, Jiaxing; Bie, Ping

    2015-08-15

    MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at post-transcriptional level. miRNA dysregulation plays a causal role in cancer progression. In this study, miR-208-3p was highly expressed and directly repressed ARID2 expression. As a result, ARID2 expression in hepatocellular carcinoma (HCC) was decreased. In vitro, miR-208-3p down-regulation and ARID2 over-expression elicited similar inhibitory effects on HCC cell proliferation and invasion. In vivo test results revealed that miR-208-3p down-regulation inhibited HCC tumorigenesis in Hep3B cells. Moreover, ARID2 was possibly a downstream element of transforming growth factor beta1 (TGFβ1)/miR-208-3p/ARID2 regulatory pathway. These findings suggested that miR-208-3p up-regulation is associated with HCC cell progression and may provide a new target for liver cancer treatment. - Highlights: • miR-208-3p was highly expressed and directly repressed the expression of ARID2 in HCC. • miR-208-3p contributed to HCC cell progression both in vitro and in vivo. • Over-expression of ARID2 inhibited the HCC cell proliferation and invasion. • Restoration of ARID2 partly reversed the the effect of miR-208-3p down-regulation on HCC cells. • Newly regulatory pathway: miR-208-3p mediated the repression of ARID2 by TGFβ1 in HCC cells.

  12. Imulation of polymer forming processes - addressing industrial needs

    SciTech Connect

    Thibault, F.; DiRaddo, R. [Industrial Materials Institute-National Research Council (Canada)

    2011-05-04

    The objective of this paper is to present the development of simulation and design optimization capabilities, for polymer forming processes, in the context of addressing industrial needs. Accomplishments generated from close to twenty years of research in this field, at the National Research Council (NRC), are presented. Polymer forming processes such as extrusion blow moulding, stretch blow moulding and thermoforming have been the focus of the work, yet the research is extendable to similar polymer forming operations such as micro-blow moulding, sheet blow moulding and composites stamping. The research considers material models, process sequence integration and design optimization, derivative processes and 3D finite elements with multi-body contact.

  13. Content-addressable memory based enforcement of configurable policies

    SciTech Connect

    Berg, Michael J

    2014-05-06

    A monitoring device for monitoring transactions on a bus includes content-addressable memory ("CAM") and a response policy unit. The CAM includes an input coupled to receive a bus transaction tag based on bus traffic on the bus. The CAM stores data tags associated with rules of a security policy to compare the bus transaction tag to the data tags. The CAM generates an output signal indicating whether one or more matches occurred. The response policy unit is coupled to the CAM to receive the output signal from the CAM and to execute a policy action in response to the output signal.

  14. A novel electron gun with an independently addressable cathode array.

    SciTech Connect

    Rudys, Joseph Matthew; Reed, Kim Warren; Pea, Gary Edward; Schneider, Larry X.

    2006-08-01

    The design of a novel electron gun with an array of independently addressable cathode elements is presented. Issues relating to operation in a 6.5 Tesla axial magnetic field are discussed. Simulations with the TriComp [1] electromagnetic field code that were used to determine the space charge limited tube characteristic and to model focusing of the electron beam in the magnetic field are reviewed. Foil heating and stress calculations are discussed. The results of CYLTRAN [2] simulations yielding the energy spectrum of the electron beam and the current transmitted through the foil window are presented.

  15. Recent NRC research activities addressing valve and pump issues

    SciTech Connect

    Morrison, D.L.

    1996-12-01

    The mission of the U.S. Nuclear Regulatory Commission (NRC) is to ensure the safe design, construction, and operation of commercial nuclear power plants and other facilities in the U.S.A. One of the main roles that the Office of Nuclear Regulatory Research (RES) plays in achieving the NRC mission is to plan, recommend, and implement research programs that address safety and technical issues deemed important by the NRC. The results of the research activities provide the bases for developing NRC positions or decisions on these issues. Also, RES performs confirmatory research for developing the basis to evaluate industry responses and positions on various regulatory requirements. This presentation summarizes some recent RES supported research activities that have addressed safety and technical issues related to valves and pumps. These activities include the efforts on determining valve and motor-operator responses under dynamic loads and pressure locking events, evaluation of monitoring equipment, and methods for detecting and trending aging of check valves and pumps. The role that RES is expected to play in future years to fulfill the NRC mission is also discussed.

  16. Compensated individually addressable array technology for human breast imaging

    DOEpatents

    Lewis, D. Kent

    2003-01-01

    A method of forming broad bandwidth acoustic or microwave beams which encompass array design, array excitation, source signal preprocessing, and received signal postprocessing. This technique uses several different methods to achieve improvement over conventional array systems. These methods are: 1) individually addressable array elements; 2) digital-to-analog converters for the source signals; 3) inverse filtering from source precompensation; and 4) spectral extrapolation to expand the bandwidth of the received signals. The components of the system will be used as follows: 1) The individually addressable array allows scanning around and over an object, such as a human breast, without any moving parts. The elements of the array are broad bandwidth elements and efficient radiators, as well as detectors. 2) Digital-to-analog converters as the source signal generators allow virtually any radiated field to be created in the half-space in front of the array. 3) Preprocessing allows for corrections in the system, most notably in the response of the individual elements and in the ability to increase contrast and resolution of signal propagating through the medium under investigation. 4) Postprocessing allows the received broad bandwidth signals to be expanded in a process similar to analytic continuation. Used together, the system allows for compensation to create beams of any desired shape, control the wave fields generated to correct for medium differences, and improve contract and resolution in and through the medium.

  17. MicroRNAs expression in ox-LDL treated HUVECs: MiR-365 modulates apoptosis and Bcl-2 expression

    SciTech Connect

    Qin, Bing; Xiao, Bo; Liang, Desheng; Xia, Jian; Li, Ye; Yang, Huan

    2011-06-24

    Highlights: {yields} We evaluated the role of miRNAs in ox-LDL induced apoptosis in ECs. {yields} We found 4 up-regulated and 11 down-regulated miRNAs in apoptotic ECs. {yields} Target genes of the dysregulated miRNAs regulate ECs apoptosis and atherosclerosis. {yields} MiR-365 promotes ECs apoptosis via suppressing Bcl-2 expression. {yields} MiR-365 inhibitor alleviates ECs apoptosis induced by ox-LDL. -- Abstract: Endothelial cells (ECs) apoptosis induced by oxidized low-density lipoprotein (ox-LDL) is thought to play a critical role in atherosclerosis. MicroRNAs (miRNAs) are a class of noncoding RNAs that posttranscriptionally regulate the expression of genes involved in diverse cell functions, including differentiation, growth, proliferation, and apoptosis. However, whether miRNAs are associated with ox-LDL induced apoptosis and their effect on ECs is still unknown. Therefore, this study evaluated potential miRNAs and their involvement in ECs apoptosis in response to ox-LDL stimulation. Microarray and qRT-PCR analysis performed on human umbilical vein endothelial cells (HUVECs) exposed to ox-LDL identified 15 differentially expressed (4 up- and 11 down-regulated) miRNAs. Web-based query tools were utilized to predict the target genes of the differentially expressed miRNAs, and the potential target genes were classified into different function categories with the gene ontology (GO) term and KEGG pathway annotation. In particular, bioinformatics analysis suggested that anti-apoptotic protein B-cell CLL/lymphoma 2 (Bcl-2) is a target gene of miR-365, an apoptomir up-regulated by ox-LDL stimulation in HUVECs. We further showed that transfection of miR-365 inhibitor partly restored Bcl-2 expression at both mRNA and protein levels, leading to a reduction of ox-LDL-mediated apoptosis in HUVECs. Taken together, our findings indicate that miRNAs participate in ox-LDL-mediated apoptosis in HUVECs. MiR-365 potentiates ox-LDL-induced ECs apoptosis by regulating the

  18. MiRNA-125a-5p inhibits glioblastoma cell proliferation and promotes cell differentiation by targeting TAZ

    SciTech Connect

    Yuan, Jian; Xiao, Gelei; Peng, Gang; Liu, Dingyang; Wang, Zeyou; Liao, Yiwei; Liu, Qing; Wu, Minghua; Yuan, Xianrui

    2015-02-06

    Highlights: • Expression of miR-125a-5p is inversely correlated with that of TAZ in glioma cells. • MiR-125a-5p represses TAZ expression in glioma cells. • MiR-125a-5p directly targets the 3′ UTR of TAZ mRNA and promotes its degradation. • MiR-125a-5p represses CTGF and survivin via TAZ, and inhibits glioma cell growth. • MiR-125a-5p inhibits the stem cell features of HFU-251 MG cells. - Abstract: Glioblastoma (GBM) is the most lethal brain tumor due to the resistance to conventional therapies, such as radiotherapy and chemotherapy. TAZ, an important mediator of the Hippo pathway, was found to be up-regulated in diverse cancers, including in GBM, and plays important roles in tumor initiation and progression. However, little is known about the regulation of TAZ expression in tumors. In this study, we found that miR-125a-5p is an important regulator of TAZ in glioma cells by directly targeting the TAZ 3′ UTR. MiR-125a-5p levels are inversely correlated with that of TAZ in normal astrocytes and a panel of glioma cell lines. MiR-125a-5p represses the expression of TAZ target genes, including CTGF and survivin, and inhibits cell proliferation and induces the differentiation of GBM cells; whereas over-expression of TAZ rescues the effects of miR-125a-5p. This study revealed a mechanism for TAZ deregulation in glioma cells, and also demonstrated a tumor suppressor role of miR-125a-5p in glioblastoma cells.

  19. Western Wind Strategy: Addressing Critical Issues for Wind Deployment

    SciTech Connect

    Douglas Larson; Thomas Carr

    2012-03-30

    The goal of the Western Wind Strategy project was to help remove critical barriers to wind development in the Western Interconnection. The four stated objectives of this project were to: (1) identify the barriers, particularly barriers to the operational integration of renewables and barriers identified by load-serving entities (LSEs) that will be buying wind generation, (2) communicate the barriers to state officials, (3) create a collaborative process to address those barriers with the Western states, utilities and the renewable industry, and (4) provide a role model for other regions. The project has been on the forefront of identifying and informing state policy makers and utility regulators of critical issues related to wind energy and the integration of variable generation. The project has been a critical component in the efforts of states to push forward important reforms and innovations that will enable states to meet their renewable energy goals and lower the cost to consumers of integrating variable generation.

  20. Network Security Mechanisms Utilizing Dynamic Network Address Translation LDRD Project

    SciTech Connect

    PRICE, CARRIE M.; STANTON, ERIC; LEE, ERIK J.; MICHALSKI, JOHN T.; CHUA, KUAN SEAH; WONG, YIP HENG; TAN, CHUNG PHENG

    2002-11-01

    A new protocol technology is just starting to emerge from the laboratory environment. Its stated purpose is to provide an additional means in which networks, and the services that reside on them, can be protected from adversarial compromise. This report has a two-fold objective. First is to provide the reader with an overview of this emerging Dynamic Defenses technology using Dynamic Network Address Translation (Dynat). This ''structure overview'' is concentrated in the body of the report, and describes the important attributes of the technology. The second objective is to provide a framework that can be used to help in the classification and assessment of the different types of dynamic defense technologies along with some related capabilities and limitations. This information is primarily contained in the appendices.

  1. The NuMI proton beam at Fermilab successes and challenges

    SciTech Connect

    Childress, S.; /Fermilab

    2008-11-01

    The NuMI beam at Fermilab has delivered over 5 x 10{sup 20} 120 GeV protons to the neutrino production target since the start for MINOS [1] neutrino oscillation experiment operation in 2005. We report on proton beam commissioning and operation status, including successes and challenges with this beam.

  2. DOE Zero Energy Ready Home Case Study: Cobblestone Homes, Midland, MI

    Office of Energy Efficiency and Renewable Energy (EERE)

    Case study of a DOE Zero Energy Ready home in Midland, MI, that scored HERS 49 without PV or HERS 44 with 1.4 kW of PV. The custom home served as a prototype and energy efficiency demonstration...

  3. MiR-18a regulates the proliferation, migration and invasion of human glioblastoma cell by targeting neogenin

    SciTech Connect

    Song, Yichen; Wang, Ping; Zhao, Wei; Yao, Yilong; Liu, Xiaobai; Ma, Jun; Xue, Yixue; Liu, Yunhui

    2014-05-15

    MiR-17-92 cluster has recently been reported as an oncogene in some tumors. However, the association of miR-18a, an important member of this cluster, with glioblastoma remains unknown. Therefore, this study aims to investigate the expression of miR-18a in glioblastoma and its role in biological behavior of U87 and U251 human glioblastoma cell lines. Quantitative RT-PCR results showed that miR-18a was highly expressed in glioblastoma tissues and U87 and U251 cell lines compared with that in human brain tissues and primary normal human astrocytes, and the expression levels were increased along with the rising pathological grades of glioblastoma. Neogenin was identified as the target gene of miR-18a by dual-luciferase reporter assays. RT-PCR and western blot results showed that its expression levels were decreased along with the rising pathological grades of glioblastoma. Inhibition of miR-18a expression was established by transfecting exogenous miR-18a inhibitor into U87 and U251 cells, and its effects on the biological behavior of glioblastoma cells were studied using CCK-8 assay, transwell assay and flow cytometry. Inhibition of miR-18a expression in U87 and U251 cells significantly up-regulated neogenin, and dramatically suppressed the abilities of cell proliferation, migration and invasion, induced cell cycle arrest and promoted cellular apoptosis. Collectively, these results suggest that miR-18a may regulate biological behavior of human glioblastoma cells by targeting neogenin, and miR-18a can serve as a potential target in the treatment of glioblastoma. - Highlights: • MiR-18a was highly expressed in glioblastoma tissues and U87 and U251 cell lines. • Neogenin was identified as the target gene of miR-18a. • Neogenin expressions were decreased along with the rising pathological grades of glioblastoma. • Inhibition of miR-18a suppressed biological behavior of glioma cells by up-regulating neogenin.

  4. miR-7 and miR-218 epigenetically control tumor suppressor genes RASSF1A and Claudin-6 by targeting HoxB3 in breast cancer

    SciTech Connect

    Li, Qiaoyan; Zhu, Fufan; Chen, Puxiang

    2012-07-20

    Highlights: Black-Right-Pointing-Pointer Both miR-7 and miR-218 down-regulates HoxB3 expression by targeting the 3 Prime -UTR of HoxB3 mRNA. Black-Right-Pointing-Pointer A reverse correlation between the levels of endogenous miR-7, miR218 and HoxB3 expression. Black-Right-Pointing-Pointer Epigenetic changes involve in the reactivation of HoxB3. Black-Right-Pointing-Pointer Both miRNAs inhibits the cell cycle and clone formation of breast cancer cells. -- Abstract: Many microRNAs have been implicated as key regulators of cellular growth and differentiation and have been found to dysregulate proliferation in human tumors, including breast cancer. Cancer-linked microRNAs also alter the epigenetic landscape by way of DNA methylation and post-translational modifications of histones. Aberrations in Hox gene expression are important for oncogene or tumor suppressor during abnormal development and malignancy. Although recent studies suggest that HoxB3 is critical in breast cancer, the putative role(s) of microRNAs impinging on HoxB3 is not yet fully understood. In this study, we found that the expression levels of miR-7 and miR-218 were strongly and reversely associated with HoxB3 expression. Stable overexpression of miR-7 and miR-218 was accompanied by reactivation of tumor suppressor genes including RASSF1A and Claudin-6 by means of epigenetic switches in DNA methylation and histone modification, giving rise to inhibition of the cell cycle and clone formation of breast cancer cells. The current study provides a novel link between overexpression of collinear Hox genes and multiple microRNAs in human breast malignancy.

  5. Health assessment for Hooker Chemical (102nd Street Landfill), Niagara Falls, New York, Region 2. CERCLIS No. NYD980506810. Preliminary report

    SciTech Connect

    Not Available

    1989-06-01

    The 102nd Street Landfill is two sites that comprise 22 acres. Occidental Chemical Corporation (OCC) and its predecessor, the Oldbury Electrochemical Company, deposited approximately 23,500 tons of mixed organic solvents, organic and inorganic phosphates, and related chemicals. Included in the site are approximately 300 tons of hexachlorocyclohexane process cake, including lindane. In addition, brine sludge, fly ash, electrochemical cell parts and related equipment in unknown quantities were dumped at the site. On-site contamination of the 102nd Street Landfill includes soils contaminated with non-aqueous phase liquids on both portions of the Landfill. Off-site contamination, based on current studies, results from contaminated ground-water leaching into the Niagara River which causes contamination of the river water, sediments, and aquatic organisms, including fish. The 102nd Street Landfill continues to represent a potential public health threat.

  6. Addressing the Need for Independence in the CSE Model

    SciTech Connect

    Abercrombie, Robert K; Ferragut, Erik M; Sheldon, Frederick T; Grimaila, Michael R

    2011-01-01

    Abstract Information system security risk, defined as the product of the monetary losses associated with security incidents and the probability that they occur, is a suitable decision criterion when considering different information system architectures. Risk assessment is the widely accepted process used to understand, quantify, and document the effects of undesirable events on organizational objectives so that risk management, continuity of operations planning, and contingency planning can be performed. One technique, the Cyberspace Security Econometrics System (CSES), is a methodology for estimating security costs to stakeholders as a function of possible risk postures. In earlier works, we presented a computational infrastructure that allows an analyst to estimate the security of a system in terms of the loss that each stakeholder stands to sustain, as a result of security breakdowns. Additional work has applied CSES to specific business cases. The current state-of-the-art of CSES addresses independent events. In typical usage, analysts create matrices that capture their expert opinion, and then use those matrices to quantify costs to stakeholders. This expansion generalizes CSES to the common real-world case where events may be dependent.

  7. Addressing Energy Demand through Demand Response. International Experiences and Practices

    SciTech Connect

    Shen, Bo; Ghatikar, Girish; Ni, Chun Chun; Dudley, Junqiao; Martin, Phil; Wikler, Greg

    2012-06-01

    Demand response (DR) is a load management tool which provides a cost-effective alternative to traditional supply-side solutions to address the growing demand during times of peak electrical load. According to the US Department of Energy (DOE), demand response reflects “changes in electric usage by end-use customers from their normal consumption patterns in response to changes in the price of electricity over time, or to incentive payments designed to induce lower electricity use at times of high wholesale market prices or when system reliability is jeopardized.” 1 The California Energy Commission (CEC) defines DR as “a reduction in customers’ electricity consumption over a given time interval relative to what would otherwise occur in response to a price signal, other financial incentives, or a reliability signal.” 2 This latter definition is perhaps most reflective of how DR is understood and implemented today in countries such as the US, Canada, and Australia where DR is primarily a dispatchable resource responding to signals from utilities, grid operators, and/or load aggregators (or DR providers).

  8. Software programs that address site-specific inventory characteristics issues.

    SciTech Connect

    Dare, J. H.; Cournoyer, M. E.

    2001-01-01

    The proper characterization of Hazardous, Mixed Low-Level, and Mixed Transuranic waste enhances productivity and safety. Hazardous material criteria that need to be considered include physical and health hazards inherent to the waste stream. Other factors that may influence characterization include: particulate diameter, complexing or chelating agent properties, lead, and mercury content, pressurized containers, and P-listed wastes. To meet these requirements are only a simple matter of generating a database with the proper fields. Manufactures and institutional databases bank huge sources of information, such as, work control documents, substance identification, container types, components of mixtures, physical property data, and regulatory data. In this report, utilization of commercially available software programs to take advantage of these resources in addressing waste characterization issues are presented. The application of user-friendly programs eliminates part of the tediousness associated with the complex requirements of certifying to general waste acceptance criteria with minimal impact on programmatic work. In other words, tapping into manufacturer and institutional database provides a way to take advantage of the combined expertise of these resources in managing a cost effective waste certification program as well as adding a quality assurance element to the program.

  9. Hidden benefits of electric vehicles for addressing climate change

    SciTech Connect

    Li, Canbing; Cao, Yijia; Zhang, Mi; Wang, Jianhui; Liu, Jianguo; Shi, Haiqing; Geng, Yinghui

    2015-03-19

    There is an increasingly hot debate on whether the replacement of conventional vehicles (CVs) by electric vehicles (EVs) should be delayed or accelerated since EVs require higher cost and cause more pollution than CVs in the manufacturing process. Here we reveal two hidden benefits of EVs for addressing climate change to support the imperative acceleration of replacing CVs with EVs. As EVs emit much less heat than CVs within the same mileage, the replacement can mitigate urban heat island effect (UHIE) to reduce the energy consumption of air conditioners, benefitting local and global climates. To demonstrate these effects brought by the replacement of CVs by EVs, we take Beijing, China, as an example. EVs emit only 19.8% of the total heat emitted by CVs per mile. The replacement of CVs by EVs in 2012 could have mitigated the summer heat island intensity (HII) by about 0.94°C, reduced the amount of electricity consumed daily by air conditioners in buildings by 14.44 million kilowatt-hours (kWh), and reduced daily CO₂ emissions by 10,686 tonnes.

  10. Hidden benefits of electric vehicles for addressing climate change

    DOE PAGES [OSTI]

    Li, Canbing; Cao, Yijia; Zhang, Mi; Wang, Jianhui; Liu, Jianguo; Shi, Haiqing; Geng, Yinghui

    2015-03-19

    There is an increasingly hot debate on whether the replacement of conventional vehicles (CVs) by electric vehicles (EVs) should be delayed or accelerated since EVs require higher cost and cause more pollution than CVs in the manufacturing process. Here we reveal two hidden benefits of EVs for addressing climate change to support the imperative acceleration of replacing CVs with EVs. As EVs emit much less heat than CVs within the same mileage, the replacement can mitigate urban heat island effect (UHIE) to reduce the energy consumption of air conditioners, benefitting local and global climates. To demonstrate these effects brought bymore » the replacement of CVs by EVs, we take Beijing, China, as an example. EVs emit only 19.8% of the total heat emitted by CVs per mile. The replacement of CVs by EVs in 2012 could have mitigated the summer heat island intensity (HII) by about 0.94°C, reduced the amount of electricity consumed daily by air conditioners in buildings by 14.44 million kilowatt-hours (kWh), and reduced daily CO₂ emissions by 10,686 tonnes.« less

  11. Loss of expression of miR-335 is implicated in hepatic stellate cell migration and activation

    SciTech Connect

    Chen, Chao; Wu, Chao-Qun; Zhang, Zong-Qi; Yao, Ding-Kang; Zhu, Liang

    2011-07-15

    Activation and migration of resident stellate cells (HSCs) within the hepatic space of Disse play an important role in hepatic fibrosis, which accounts for the increased numbers of activated HSCs in areas of inflammation during hepatic fibrosis. Currently, microRNAs have been found to play essential roles in HSC differentiation, proliferation, apoptosis, fat accumulation and collagen production. However, little is known about microRNA mediated HSC activation and migration. In this study, the miRNA expression profiles of quiescent HSCs, partially activated HSCs and fully activated HSCs were compared in pairs. Gene ontology (GO) and GO-Map network analysis indicated that the activation of HSCs was regulated by microRNAs. Among them miR-335 was confirmed to be significantly reduced during HSC activation by qRT-PCR, and restoring expression of miR-335 inhibited HSC migration and reduced {alpha}-SMA and collagen type I. Previous study revealed that tenascin-C (TNC), an extracellular matrix glycoprotein involved in cell migration, might be a target of miR-335. Therefore, we further studied the TNC expression in miR-335 over-expressed HSCs. Our data showed that exogenous TNC could enhance HSC migration in vitro and miR-335 restoration resulted in a significant inhibition of TNC expression. These results demonstrated that miR-335 restoration inhibited HSC migration, at least in part, via downregulating the TNC expression.

  12. PSMB4 promotes multiple myeloma cell growth by activating NF-κB-miR-21 signaling

    SciTech Connect

    Zheng, Peihao; Guo, Honggang; Li, Guangchao; Han, Siqi; Luo, Fei; Liu, Yi

    2015-03-06

    Proteasomal subunit PSMB4, was recently identified as potential cancer driver genes in several tumors. However, the regulatory mechanism of PSMB4 on carcinogenesis process remains unclear. In this study, we investigated the expression and roles of PSMB4 in multiple myeloma (MM). We found a significant up-regulation of PSMB4 in MM plasma and cell lines. Ectopic overexpression of PSMB4 promoted cell growth and colony forming ability of MM cells, whereas inhibition of PSMB4 led to a decrease of such events. Furthermore, our results demonstrated the up-regulation of miR-21 and a positive correlation between the levels of miR-21 and PSMB4 in MM. Re-expression of miR-21 markedly rescued PSMB4 knockdown-mediated suppression of cell proliferation and clone-formation. Additionally, while enforced expression of PSMB4 profoundly increased NF-κB activity and the level of miR-21, PSMB4 knockdown or NF-κB inhibition suppressed miR-21 expression in MM cells. Taken together, our results demonstrated that PSMB4 regulated MM cell growth in part by activating NF-κB-miR-21 signaling, which may represent promising targets for novel specific therapies. - Highlights: • First reported upregulation of PSMB4 in MM plasma and cell lines. • PSMB4 promoted MM cell growth and colony forming ability. • Further found miR-21 was up-regulated by PSMB4 in MM plasma and cell lines. • PSMB4-induced miR-21 expression was modulated by NF-κB. • PSMB4-NF-κB-miR-21 axis may be potential therapeutic targets of MM.

  13. Addressing Water Consumption of Evaporative Coolers with Greywater

    SciTech Connect

    Sahai, Rashmi; Shah, Nihar; Phadke, Amol

    2012-07-01

    Evaporative coolers (ECs) provide significant gains in energy efficiency compared to vapor compression air conditioners, but simultaneously have significant onsite water demand. This can be a major barrier to deployment in areas of the world with hot and arid climates. To address this concern, this study determined where in the world evaporative cooling is suitable, the water consumption of ECs in these cities, and the potential that greywater can be used reduce the consumption of potable water in ECs. ECs covered 69percent of the cities where room air conditioners are may be deployed, based on comfort conditions alone. The average water consumption due to ECs was found to be 400 L/household/day in the United States and Australia, with the potential for greywater to provide 50percent this amount. In the rest of the world, the average water consumption was 250 L/household/day, with the potential for greywater to supply 80percent of this amount. Home size was the main factor that contributed to this difference. In the Mediterranean, the Middle East, Northern India, and the Midwestern and Southwestern United States alkalinity levels are high and water used for bleeding will likely contribute significantly to EC water consumption. Although technically feasible, upfront costs for household GW systems are currently high. In both developed and developing parts of the world, however, a direct EC and GW system is cost competitive with conventional vapor compression air conditioners. Moreover, in regions of the world that face problems of water scarcity the benefits can substantially outweigh the costs.

  14. Regulatory approaches for addressing dissolved oxygen concerns at hydropower facilities

    SciTech Connect

    Peterson, Mark J.; Cada, Glenn F.; Sale, Michael J.; Eddlemon, Gerald K.

    2003-03-01

    Low dissolved oxygen (DO) concentrations are a common water quality problem downstream of hydropower facilities. At some facilities, structural improvements (e.g. installation of weir dams or aerating turbines) or operational changes (e.g., spilling water over the dam) can be made to improve DO levels. In other cases, structural and operational approaches are too costly for the project to implement or are likely to be of limited effectiveness. Despite improvements in overall water quality below dams in recent years, many hydropower projects are unable to meet state water quality standards for DO. Regulatory agencies in the U.S. are considering or implementing dramatic changes in their approach to protecting the quality of the Nations waters. New policies and initiatives have emphasized flexibility, increased collaboration and shared responsibility among all parties, and market-based, economic incentives. The use of new regulatory approaches may now be a viable option for addressing the DO problem at some hydropower facilities. This report summarizes some of the regulatory-related options available to hydropower projects, including negotiation of site-specific water quality criteria, use of biological monitoring, watershed-based strategies for the management of water quality, and watershed-based trading. Key decision points center on the health of the local biological communities and whether there are contributing impacts (i.e., other sources of low DO effluents) in the watershed. If the biological communities downstream of the hydropower project are healthy, negotiation for site-specific water quality standards or biocriteria (discharge performance criteria based on characteristics of the aquatic biota) might be pursued. If there are other effluent dischargers in the watershed that contribute to low DO problems, watershed-scale strategies and effluent trading may be effective. This report examines the value of regulatory approaches by reviewing their use in other

  15. Addressing Fission Product Validation in MCNP Burnup Credit Criticality Calculations

    SciTech Connect

    Mueller, Don; Bowen, Douglas G; Marshall, William BJ J

    2015-01-01

    The US Nuclear Regulatory Commission (NRC) Division of Spent Fuel Storage and Transportation issued Interim Staff Guidance (ISG) 8, Revision 3 in September 2012. This ISG provides guidance for NRC staff members’ review of burnup credit (BUC) analyses supporting transport and dry storage of pressurized water reactor spent nuclear fuel (SNF) in casks. The ISG includes guidance for addressing validation of criticality (keff) calculations crediting the presence of a limited set of fission products and minor actinides (FP&MAs). Based on previous work documented in NRC Regulatory Guide (NUREG) Contractor Report (CR)-7109, the ISG recommends that NRC staff members accept the use of either 1.5 or 3% of the FP&MA worth—in addition to bias and bias uncertainty resulting from validation of keff calculations for the major actinides in SNF—to conservatively account for the bias and bias uncertainty associated with the specified unvalidated FP&MAs. The ISG recommends (1) use of 1.5% of the FP&MA worth if a modern version of SCALE and its nuclear data are used and (2) 3% of the FP&MA worth for well qualified, industry standard code systems other than SCALE with the Evaluated Nuclear Data Files, Part B (ENDF/B),-V, ENDF/B-VI, or ENDF/B-VII cross sections libraries. The work presented in this paper provides a basis for extending the use of the 1.5% of the FP&MA worth bias to BUC criticality calculations performed using the Monte Carlo N-Particle (MCNP) code. The extended use of the 1.5% FP&MA worth bias is shown to be acceptable by comparison of FP&MA worths calculated using SCALE and MCNP with ENDF/B-V, -VI, and -VII–based nuclear data. The comparison supports use of the 1.5% FP&MA worth bias when the MCNP code is used for criticality calculations, provided that the cask design is similar to the hypothetical generic BUC-32 cask model and that the credited FP&MA worth is no more than 0.1 Δkeff (ISG-8, Rev. 3, Recommendation 4).

  16. RLIP76-dependent suppression of PI3K/AKT/Bcl-2 pathway by miR...

    Office of Scientific and Technical Information (OSTI)

    in prostate cancer Citation Details In-Document Search Title: RLIP76-dependent suppression of PI3KAKTBcl-2 pathway by miR-101 induces apoptosis in prostate cancer MicroRNA-101 ...

  17. Aryl hydrocarbon receptor-dependent regulation of miR-196a expression controls lung fibroblast apoptosis but not proliferation

    SciTech Connect

    Hecht, Emelia; Zago, Michela; Sarill, Miles; Rico de Souza, Angela; Gomez, Alvin; Matthews, Jason; Hamid, Qutayba; Eidelman, David H.; Baglole, Carolyn J.

    2014-11-01

    The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor implicated in the regulation of apoptosis and proliferation. Although activation of the AhR by xenobiotics such as dioxin inhibits the cell cycle and control apoptosis, paradoxically, AhR expression also promotes cell proliferation and survival independent of exogenous ligands. The microRNA (miRNA) miR-196a has also emerged as a regulator of proliferation and apoptosis but a relationship between the AhR and miR-196a is not known. Therefore, we hypothesized that AhR-dependent regulation of endogenous miR-196a expression would promote cell survival and proliferation. Utilizing lung fibroblasts from AhR deficient (AhR{sup −/−}) and wild-type (AhR{sup +/+}) mice, we show that there is ligand-independent regulation of miRNA, including low miR-196a in AhR{sup −/−} cells. Validation by qRT-PCR revealed a significant decrease in basal expression of miR-196a in AhR{sup −/−} compared to AhR{sup +/+} cells. Exposure to AhR agonists benzo[a]pyrene (B[a]P) and FICZ as well as AhR antagonist CH-223191 decreased miR-196a expression in AhR{sup +/+} fibroblasts concomitant with decreased AhR protein levels. There was increased proliferation only in AhR{sup +/+} lung fibroblasts in response to serum, corresponding to a decrease in p27{sup KIP1} protein, a cyclin-dependent kinase inhibitor. Increasing the cellular levels of miR-196a had no effect on proliferation or expression of p27{sup KIP1} in AhR{sup −/−} fibroblasts but attenuated cigarette smoke-induced apoptosis. This study provides the first evidence that AhR expression is essential for the physiological regulation of cellular miRNA levels- including miR-196a. Future experiments designed to elucidate the functional relationship between the AhR and miR-196a may delineate additional novel ligand-independent roles for the AhR. - Highlights: • The AhR controls proliferation and apoptosis in lung cells. • The AhR regulates the

  18. Material Activation Benchmark Experiments at the NuMI Hadron Absorber Hall in Fermilab

    SciTech Connect

    Matsumura, H.; Matsuda, N.; Kasugai, Y.; Toyoda, A.; Yashima, H.; Sekimoto, S.; Iwase, H.; Oishi, K.; Sakamoto, Y.; Nakashima, H.; Leveling, A.; Boehnlein, D.; Lauten, G.; Mokhov, N.; Vaziri, K.

    2014-06-15

    In our previous study, double and mirror symmetric activation peaks found for Al and Au arranged spatially on the back of the Hadron absorber of the NuMI beamline in Fermilab were considerably higher than those expected purely from muon-induced reactions. From material activation bench-mark experiments, we conclude that this activation is due to hadrons with energy greater than 3 GeV that had passed downstream through small gaps in the hadron absorber.

  19. Measurement of Pi-K Ratios from the NuMI Target

    SciTech Connect

    Seun, Sin Man

    2007-07-01

    Interactions of protons (p) with the NuMI (Neutrinos at the Main Injector) target are used to create the neutrino beam for the MINOS (Main Injector Neutrino Oscillation Search) Experiment. Using the MIPP (Main Injector Particle Production) experimental apparatus, the production of charged pions and kaons in p+NuMI interactions is studied. The data come from a sample of 2 x 106 events obtained by MIPP using the 120 GeV/c proton beam from the Main Injector at Fermi National Accelerator Laboratory in Illinois, USA. Pions and kaons are identified by measurement in a Ring Imaging Cherenkov detector. Presented are measurements of π-+, K-/K+, π+/K+ and π-/K- production ratios in the momentum range pT < 2 GeV/c transversely and 20 GeV/c < pz < 90 GeV/c longitudinally. Also provided are detailed comparisons of the MIPP NuMI data with the MIPP Thin Carbon data, the MIPP Monte Carlo simulation and the current MINOS models in the relevant momentum ranges.

  20. miR-21 modulates tumor outgrowth induced by human adipose tissue-derived mesenchymal stem cells in vivo

    SciTech Connect

    Shin, Keun Koo; Lee, Ae Lim; Kim, Jee Young; Medical Research Center for Ischemic Tissue Engineering, Pusan National University, Yangsan, Gyeongnam 626-870; BK21 Medical Science Education Center, School of Medicine, Pusan National University, Yangsan, Gyeongnam 626-870 ; Lee, Sun Young; Medical Research Center for Ischemic Tissue Engineering, Pusan National University, Yangsan, Gyeongnam 626-870 ; Bae, Yong Chan; Jung, Jin Sup

    2012-06-15

    Highlights: Black-Right-Pointing-Pointer miR-21 modulates hADSC-induced increase of tumor growth. Black-Right-Pointing-Pointer The action is mostly mediated by the modulation of TGF-{beta} signaling. Black-Right-Pointing-Pointer Inhibition of miR-21 enhances the blood flow recovery in hindlimb ischemia. -- Abstract: Mesenchymal stem cells (MSCs) have generated a great deal of interest in clinical situations, due principally to their potential use in regenerative medicine and tissue engineering applications. However, the therapeutic application of MSCs remains limited, unless the favorable effects of MSCs on tumor growth in vivo, and the long-term safety of the clinical applications of MSCs, can be more thoroughly understood. In this study, we determined whether microRNAs can modulate MSC-induced tumor outgrowth in BALB/c nude mice. Overexpression of miR-21 in human adipose-derived stem cells (hADSCs) inhibited hADSC-induced tumor growth, and inhibition of miR-21 increased it. Downregulation of transforming growth factor beta receptor II (TGFBR2), but not of signal transducer and activator of transcription 3, in hADSCs showed effects similar to those of miR-21 overexpression. Downregulation of TGFBR2 and overexpression of miR21 decreased tumor vascularity. Inhibition of miR-21 and the addition of TGF-{beta} increased the levels of vascular endothelial growth factor and interleukin-6 in hADSCs. Transplantation of miR-21 inhibitor-transfected hADSCs increased blood flow recovery in a hind limb ischemia model of nude mice, compared with transplantation of control oligo-transfected cells. These findings indicate that MSCs might favor tumor growth in vivo. Thus, it is necessary to study the long-term safety of this technique before MSCs can be used as therapeutic tools in regenerative medicine and tissue engineering.

  1. Targeting miR-21 enhances the sensitivity of human colon cancer HT-29 cells to chemoradiotherapy in vitro

    SciTech Connect

    Deng, Jun; Lei, Wan; Fu, Jian-Chun; Zhang, Ling; Li, Jun-He; Xiong, Jian-Ping

    2014-01-17

    Highlight: MiR-21 plays a significant role in 5-FU resistance. This role might be attributed to targeting of hMSH2 as well as TP and DPD via miR-21 targeted hMSH2. Indirectly targeted TP and DPD to influence 5-FU chemotherapy sensitivity. -- Abstract: 5-Fluorouracil (5-FU) is a classic chemotherapeutic drug that has been widely used for colorectal cancer treatment, but colorectal cancer cells are often resistant to primary or acquired 5-FU therapy. Several studies have shown that miR-21 is significantly elevated in colorectal cancer. This suggests that this miRNA might play a role in this resistance. In this study, we investigated this possibility and the possible mechanism underlying this role. We showed that forced expression of miR-21 significantly inhibited apoptosis, enhanced cell proliferation, invasion, and colony formation ability, promoted G1/S cell cycle transition and increased the resistance of tumor cells to 5-FU and X radiation in HT-29 colon cancer cells. Furthermore, knockdown of miR-21 reversed these effects on HT-29 cells and increased the sensitivity of HT-29/5-FU to 5-FU chemotherapy. Finally, we showed that miR-21 targeted the human mutS homolog2 (hMSH2), and indirectly regulated the expression of thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD). These results demonstrate that miR-21 may play an important role in the 5-FU resistance of colon cancer cells.

  2. miR-502 inhibits cell proliferation and tumor growth in hepatocellular carcinoma through suppressing phosphoinositide 3-kinase catalytic subunit gamma

    SciTech Connect

    Chen, Suling; Li, Fang; Chai, Haiyun; Tao, Xin; Wang, Haili; Ji, Aifang

    2015-08-21

    MicroRNAs (miRNAs) play a key role in carcinogenesis and tumor progression in hepatocellular carcinoma (HCC). In the present study, we demonstrated that miR-502 significantly inhibits HCC cell proliferation in vitro and tumor growth in vivo. G1/S cell cycle arrest and apoptosis of HCC cells were induced by miR-502. Phosphoinositide 3-kinase catalytic subunit gamma (PIK3CG) was identified as a direct downstream target of miR-502 in HCC cells. Notably, overexpression of PIK3CG reversed the inhibitory effects of miR-502 in HCC cells. Our findings suggest that miR-502 functions as a tumor suppressor in HCC via inhibition of PI3KCG, supporting its utility as a promising therapeutic gene target for this tumor type. - Highlights: • miR-502 suppresses HCC cell proliferation in vitro and tumorigenicity in vivo. • miR-502 regulates cell cycle and apoptosis in HCC cells. • PIK3CG is a direct target of miR-502. • miR-502 and PIK3CG expression patterns are inversely correlated in HCC tissues.

  3. RLIP76-dependent suppression of PI3K/AKT/Bcl-2 pathway by miR-101 induces apoptosis in prostate cancer

    SciTech Connect

    Yang, Jing; Song, Qi; Cai, Yi; Wang, Peng; Wang, Min; Zhang, Dong

    2015-08-07

    MicroRNA-101 (miR-101) participates in carcinogenesis and tumor progression in various cancers. However, its biological functions in prostate cancer are still unclear. Here, we demonstrate that miR-101 represents a critical role in regulating cell apoptosis in prostate cancer cells. We first demonstrated that miR-101 treatment promoted apoptosis in DU145 and PC3 cells by using flow cytometric analysis and transmission electron microscopy (TEM). To verify the mechanisms, we identified a novel miR-101 target, Ral binding protein 1 (RLIP76). We found miR-101 transfection significantly suppresses RLIP76 expression, which can transactivate phosphorylation of PI3K-Akt signaling, and resulted in an amplification of Bcl2-induced apoptosis. Furthermore, we demonstrated that RLIP76 overexpression could reverse the anti-tumor effects of miR-101 in DU145 and PC3 cells by using flow cytometry assay and MTT assay. Taken together, our results revealed that the effect of miR-101 on prostate cancer cell apoptosis was due to RLIP76 regulation of the PI3K/Akt/Bcl-2 signaling pathway. - Highlights: • miR-101 inhibited prostate cancer cell proliferation and enhanced apoptosis. • miR-101 directly targeted and regulated RLIP76 expression. • miR-101 suppressed PI3K/Akt/Bcl-2 signaling pathway by targeting RLIP76.

  4. MiR-20a Induces Cell Radioresistance by Activating the PTEN/PI3K/Akt Signaling Pathway in Hepatocellular Carcinoma

    SciTech Connect

    Zhang, Yuqin; Zheng, Lin; Ding, Yi; Li, Qi; Wang, Rong; Liu, Tongxin; Sun, Quanquan; Yang, Hua; Peng, Shunli; Wang, Wei; Chen, Longhua

    2015-08-01

    Purpose: To investigate the role of miR-20a in hepatocellular carcinoma (HCC) cell radioresistance, which may reveal potential strategies to improve treatment. Methods and Materials: The expression of miR-20a and PTEN were detected in HCC cell lines and paired primary tissues by quantitative real-time polymerase chain reaction. Cell radiation combined with colony formation assays was administrated to discover the effect of miR-20a on radiosensitivity. Bioinformatics prediction and luciferase assay were used to identify the target of miR-20a. The phosphatidylinositol 3-kinase inhibitor LY294002 was used to inhibit phosphorylation of Akt, to verify whether miR-20a affects HCC cell radioresistance through activating the PTEN/PI3K/Akt pathway. Results: MiR-20a levels were increased in HCC cell lines and tissues, whereas PTEN was inversely correlated with it. Overexpression of miR-20a in Bel-7402 and SMMC-7721 cells enhances their resistance to the effect of ionizing radiation, and the inhibition of miR-20a in HCCLM3 and QGY-7701 cells sensitizes them to it. PTEN was identified as a direct functional target of miR-20a for the induction of radioresistance. Overexpression of miR-20a activated the PTEN/PI3K/Akt signaling pathway. Additionally, the kinase inhibitor LY294002 could reverse the effect of miR-20a–induced radioresistance. Conclusion: MiR-20a induces HCC cell radioresistance by activating the PTEN/PI3K/Akt pathway, which suggests that miR-20a/PTEN/PI3K/Akt might represent a target of investigation for developing effective therapeutic strategies against HCC.

  5. MiR-145 is downregulated in human ovarian cancer and modulates cell growth and invasion by targeting p70S6K1 and MUC1

    SciTech Connect

    Wu, Huijuan; Xiao, ZhengHua; Wang, Ke; Liu, Wenxin; Hao, Quan

    2013-11-29

    Highlights: •MiR-145 is downregulated in human ovarian cancer. •MiR-145 targets p70S6K1 and MUC1. •p70S6K1 and MUC1 are involved in miR-145 mediated tumor cell growth and cell invasion, respectively. -- Abstract: MicroRNAs (miRNAs) are a family of small non-coding RNA molecules that regulate gene expression at post-transcriptional levels. Previous studies have shown that miR-145 is downregulated in human ovarian cancer; however, the roles of miR-145 in ovarian cancer growth and invasion have not been fully demonstrated. In the present study, Northern blot and qRT-PCR analysis indicate that miR-145 is downregulated in ovarian cancer tissues and cell lines, as well as in serum samples of ovarian cancer, compared to healthy ovarian tissues, cell lines and serum samples. Functional studies suggest that miR-145 overexpression leads to the inhibition of colony formation, cell proliferation, cell growth viability and invasion, and the induction of cell apoptosis. In accordance with the effect of miR-145 on cell growth, miR-145 suppresses tumor growth in vivo. MiR-145 is found to negatively regulate P70S6K1 and MUC1 protein levels by directly targeting their 3′UTRs. Importantly, the overexpression of p70S6K1 and MUC1 can restore the cell colony formation and invasion abilities that are reduced by miR-145, respectively. MiR-145 expression is increased after 5-aza-CdR treatment, and 5-aza-CdR treatment results in the same phenotype as the effect of miR-145 overexpression. Our study suggests that miR-145 modulates ovarian cancer growth and invasion by suppressing p70S6K1 and MUC1, functioning as a tumor suppressor. Moreover, our data imply that miR-145 has potential as a miRNA-based therapeutic target for ovarian cancer.

  6. U-115: Novell GroupWise Client Address Book Processing Buffer Overflow Vulnerability

    Energy.gov [DOE]

    The vulnerability is caused due to an error when processing Novell Address Book (".nab") files and can be exploited to cause a heap-based buffer overflow via an overly long email address.

  7. Join @Energy for the 2015 State of the Union Address | Department...

    Energy Saver

    Join @Energy for the 2015 State of the Union Address Join @Energy for the 2015 State of the Union Address January 20, 2015 - 12:08pm Addthis Join us for live coverage of the State...

  8. AMO Deputy Director Addresses Water-Energy Nexus at 2016 Energy...

    Energy Saver

    Deputy Director Addresses Water-Energy Nexus at 2016 Energy Efficiency Global Forum AMO Deputy Director Addresses Water-Energy Nexus at 2016 Energy Efficiency Global Forum May 20, ...

  9. The long non-coding RNA H19-derived miR-675 modulates human gastric cancer cell proliferation by targeting tumor suppressor RUNX1

    SciTech Connect

    Zhuang, Ming; Gao, Wen; Xu, Jing; Wang, Ping; Shu, Yongqian

    2014-06-06

    Graphical abstract: - Highlights: • H19 regulates gastric cancer cell proliferation phenotype via miR-675. • MiR-675 modulates cell proliferation of gastric cancer cells by targeting tumor suppressor RUNX1. • The H19/miR-675/RUNX1 axis plays an important role in the tumorigenesis of gastric cancer. - Abstract: The lncRNA H19 has been recently shown to be upregulated and play important roles in gastric cancer tumorigenesis. However, the precise molecular mechanism of H19 and its mature product miR-675 in the carcinogenesis of gastric cancer remains unclear. In this study, we found that miR-675 was positively expressed with H19 and was a pivotal mediator in H19-induced gastric cancer cell growth promotion. Subsequently, the tumor suppressor Runt Domain Transcription Factor1 (RUNX1) was confirmed to be a direct target of miR-675 using a luciferase reporter assay and Western blotting analyses. A series of rescue assays indicated that RUNX1 mediated H19/miR-67-induced gastric cancer cell phenotypic changes. Moreover, the inverse relationship between the expression of RUNX1 and H19/miR-675 was also revealed in gastric cancer tissues and gastric cancer cell lines. Taken together, our study demonstrated that the novel pathway H19/miR-675/RUNX1 regulates gastric cancer development and may serve as a potential target for gastric cancer therapy.

  10. Testing CPT conservation using the NuMI neutrino beam with the MINOS experiment

    SciTech Connect

    Auty, David John

    2010-05-01

    The MINOS experiment was designed to measure neutrino oscillation parameters with muon neutrinos. It achieves this by measuring the neutrino energy spectrum and flavor composition of the man-made NuMI neutrino beam 1km after the beam is formed and again after 735 km. By comparing the two spectra it is possible to measure the oscillation parameters. The NuMI beam is made up of 7.0% {bar {nu}}{sub {mu}}, which can be separated from the {nu}{sub {mu}} because the MINOS detectors are magnetized. This makes it possible to study {bar {nu}}{sub {mu}} oscillations separately from those of muon neutrinos, and thereby test CPT invariance in the neutrino sector by determining the {bar {nu}}{sub {mu}} oscillation parameters and comparing them with those for {nu}{sub {mu}}, although any unknown physics of the antineutrino would appear as a difference in oscillation parameters. Such a test has not been performed with beam {bar {nu}}{sub {mu}} before. It is also possible to produce an almost pure {bar {nu}}{sub {mu}} beam by reversing the current through the magnetic focusing horns of the NuMI beamline, thereby focusing negatively, instead of positively charged particles. This thesis describes the analysis of the 7% {bar {nu}}{sub {mu}} component of the forward horn current NuMI beam. The {bar {nu}}{sub {mu}} of a data sample of 3.2 x 10{sup 20} protons on target analysis found 42 events, compared to a CPT conserving prediction of 58.3{sub -7.6}{sup +7.6}(stat.){sub -3.6}{sup +3.6}(syst.) events. This corresponds to a 1.9 {sigma} deficit, and a best fit value of {Delta}{bar m}{sub 32}{sup 2} = 18 x 10{sup -3} eV{sup 2} and sin{sup 2} 2{bar {theta}}{sub 23} = 0.55. This thesis focuses particularly on the selection of {bar {nu}}{sub {mu}} events, and investigates possible improvements of the selection algorithm. From this a different selector was chosen, which corroborated the findings of the original selector. The thesis also investigates how the systematic errors affect the

  11. ,"Detroit, MI Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Detroit, MI Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  12. ,"Marysville, MI Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Marysville, MI Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  13. Port Huron, MI Natural Gas Pipeline Imports From Canada (Dollars per

    Energy Information Administration (EIA) (indexed site)

    Thousand Cubic Feet) Dollars per Thousand Cubic Feet) Port Huron, MI Natural Gas Pipeline Imports From Canada (Dollars per Thousand Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2016 2.07 2.06 2.21 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Price of

  14. ,"St. Clair, MI Natural Gas Pipeline Exports to Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Exports to Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","St. Clair, MI Natural Gas Pipeline Exports to Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  15. ,"St. Clair, MI Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","St. Clair, MI Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  16. Examples of cooler reflective streets for urban heat-island mitigation : Portland cement concrete and chip seals

    SciTech Connect

    Pomerantz, M.; Akbari, H.; Chang, S.-C.; Levinson, R.; Pon, B.

    2003-04-30

    Part of the urban heat island effect can be attributed to dark pavements that are commonly used on streets and parking lots. In this paper we consider two light colored, hence cooler, alternative paving materials that are in actual use in cities today. These are Portland cement concrete (PCC) pavements and chip seals. We report measurements of the albedos of some PCC and chip sealed pavements in the San Francisco Bay Area. The albedos of the PCC pavements ranged from about 0.18 to 0.35. The temperatures of some PCC pavements are also measured and calculated. We then consider how the albedos of the constituent materials of the PCC (stone, sand and cement) contribute to the albedos of the resulting finished concrete. The albedos of a set of chip sealed pavements in San Jose, CA, were measured and correlated with the times of their placement. It is found that the albedos decrease with age (and use) but remain higher than that of standard asphalt concrete (AC) for about five years. After t hat, the albedos of the chip seals are about 0.12, similar to aged AC. The fact that many PCC pavements have albedos at least twice as high as aged AC suggests that it is possible to have pavement albedos that remain high for many years.

  17. Results of the radiological survey at the National Community Bank, 113 Essex Street, Maywood, New Jersey (MJ021)

    SciTech Connect

    Foley, R.D.; Cottrell, W.D.; Floyd, L.M.

    1989-09-01

    Maywood Chemical Works (MCW) of Maywood, New Jersey, generated process wastes and residues associated with the production and refining of thorium and thorium compounds from monazite ores from 1916 to 1956. MCW supplied rare earth metals and thorium compounds to the Atomic Energy Commission and various other government agencies from the late 1940s to the mid-1950s. Area residents used the sandlike waste from this thorium extraction process mixed with tea and cocoa leaves as mulch in their yards. Some of these contaminated wastes were also eroded from the site into Lodi Brook. At the request of the US Department of Energy (DOE), a group from Oak Ridge National Laboratory conducts investigative radiological surveys of properties in the vicinity of MCW to determine whether a property is contaminated with radioactive residues, principally {sup 232}Th, derived from the MCW site. The survey typically includes direct measurement of gamma radiation levels and soil sampling for radionuclide analyses. The survey of this site, the National Community Bank, 113 Essex Street, Maywood, New Jersey (MJ021), was conducted during 1986. Results of the survey demonstrated radionuclide concentrations in excess of the DOE Formerly Utilized Sites Remedial Action Program criteria. The radionuclide distributions are typical of the type of material originating from the MCW site. 5 refs., 2 figs., 3 tabs.

  18. Addressing Cybersecurity

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    experience in security and pushing the limits of computing comes into play. From the physicist's point of view, the only true unpredictability comes from quantum mechanics. ...

  19. 5-address

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

  20. Keynote Address

    Office of Environmental Management (EM)

    ... americium-beryllium neutron source used in oil exploration (well logging) A self-shielded ... solidified sludge associated with: - Production of molybdenum-99 (Mo-99) - Production ...

  1. Assessment of radiological releases from the NuMI facility during MINOS and NOvA operations

    SciTech Connect

    Martens, Mike; /Fermilab

    2007-04-01

    This report makes projections of the radiological releases from the NuMI facility during operations for the MINOS and NO ?A experiments. It includes an estimate of the radionuclide levels released into the atmosphere and the estimated tritium and sodium-22 concentrations in the NuMI sump water and Fermilab pond system. The analysis was performed for NuMI operations with a beam power on target increased from the present 400 kW design up to a possible 1500 kW with future upgrades. The total number of protons on target was assumed to be 18 x 10{sup 20} after the completion of MINOS and 78 x 10{sup 20} after the completion of NO ?A.

  2. Identification of miR-2400 gene as a novel regulator in skeletal muscle satellite cells proliferation by targeting MYOG gene

    SciTech Connect

    Zhang, Wei Wei; Tong, Hui Li; Sun, Xiao Feng; Hu, Qian; Yang, Yu; Li, Shu Feng; Yan, Yun Qin; Li, Guang Peng

    2015-08-07

    MicroRNAs play critical roles in skeletal muscle development as well as in regulation of muscle cell proliferation and differentiation. Previous study in our laboratory showed that the expression level of miR-2400, a novel and unique miRNA from bovine, had significantly changed in skeletal muscle-derived satellite cells (MDSCs) during differentiation, however, the function and expression pattern for miR-2400 in MDSCs has not been fully understood. In this report, we firstly identified that the expression levels of miR-2400 were down-regulated during MDSCs differentiation by stem-loop RT-PCR. Over-expression and inhibition studies demonstrated that miR-2400 promoted MDSCs proliferation by EdU (5-ethynyl-2′ deoxyuridine) incorporation assay and immunofluorescence staining of Proliferating cell nuclear antigen (PCNA). Luciferase reporter assays showed that miR-2400 directly targeted the 3′ untranslated regions (UTRs) of myogenin (MYOG) mRNA. These data suggested that miR-2400 could promote MDSCs proliferation through targeting MYOG. Furthermore, we found that miR-2400, which was located within the eighth intron of the Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) gene, was down-regulated in MDSCs in a direct correlation with the WHSC1L1 transcript by Clustered regularly interspaced palindromic repeats interference (CRISPRi). In addition, these observations not only provided supporting evidence for the codependent expression of intronic miRNAs and their host genes in vitro, but also gave insight into the role of miR-2400 in MDSCs proliferation. - Highlights: • miR-2400 is a novel and unique miRNA from bovine. • miR-2400 could promote skeletal muscle satellite cells proliferation. • miR-2400 directly targeted the 3′ untranslated regions of MYOG mRNA. • miR-2400 could be coexpressed together with its host gene WHSC1L1.

  3. miR-340 inhibits glioblastoma cell proliferation by suppressing CDK6, cyclin-D1 and cyclin-D2

    SciTech Connect

    Li, Xuesong; Gong, Xuhai; Chen, Jing; Zhang, Jinghui; Sun, Jiahang; Guo, Mian

    2015-05-08

    Glioblastoma development is often associated with alteration in the activity and expression of cell cycle regulators, such as cyclin-dependent kinases (CKDs) and cyclins, resulting in aberrant cell proliferation. Recent studies have highlighted the pivotal roles of miRNAs in controlling the development and growth of glioblastoma. Here, we provide evidence for a function of miR-340 in the inhibition of glioblastoma cell proliferation. We found that miR-340 is downregulated in human glioblastoma tissue samples and several established glioblastoma cell lines. Proliferation and neurosphere formation assays revealed that miR-340 plays an oncosuppressive role in glioblastoma, and that its ectopic expression causes significant defect in glioblastoma cell growth. Further, using bioinformatics, luciferase assay and western blot, we found that miR-340 specifically targets the 3′UTRs of CDK6, cyclin-D1 and cyclin-D2, leading to the arrest of glioblastoma cells in the G0/G1 cell cycle phase. Confirming these results, we found that re-introducing CDK6, cyclin-D1 or cyclin-D2 expression partially, but significantly, rescues cells from the suppression of cell proliferation and cell cycle arrest mediated by miR-340. Collectively, our results demonstrate that miR-340 plays a tumor-suppressive role in glioblastoma and may be useful as a diagnostic biomarker and/or a therapeutic avenue for glioblastoma. - Highlights: • miR-340 is downregulated in glioblastoma samples and cell lines. • miR-340 inhibits glioblastoma cell proliferation. • miR-340 directly targets CDK6, cyclin-D1, and cyclin-D2. • miR-340 regulates glioblastoma cell proliferation via CDK6, cyclin-D1 and cyclin-D2.

  4. ,"Sault St Marie, MI Natural Gas Pipeline Exports to Canada (Million Cubic Feet)"

    Energy Information Administration (EIA) (indexed site)

    Sault St Marie, MI Natural Gas Pipeline Exports to Canada (Million Cubic Feet)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Sault St Marie, MI Natural Gas Pipeline Exports to Canada (Million Cubic Feet)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release

  5. Assistant Secretary Patricia Hoffman to Deliver Keynote Address at IEEE PES

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Conference on Innovative Smart Grid Technologies | Department of Energy Patricia Hoffman to Deliver Keynote Address at IEEE PES Conference on Innovative Smart Grid Technologies Assistant Secretary Patricia Hoffman to Deliver Keynote Address at IEEE PES Conference on Innovative Smart Grid Technologies January 25, 2013 - 3:10pm Addthis Assistant Secretary Patricia Hoffman will give the keynote address at the 4th annual IEEE PES Conference on Innovative Smart Grid Technologies (ISGT 2013) on

  6. NBP RFI-Addressing Policy and Logistical Challenges to Smart Grid

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Implementation. September 10, 2009 | Department of Energy NBP RFI-Addressing Policy and Logistical Challenges to Smart Grid Implementation. September 10, 2009 NBP RFI-Addressing Policy and Logistical Challenges to Smart Grid Implementation. September 10, 2009 The Telecommunications Industry Association (TIA) is pleased to provide comments on how to address the numerous challenges facing the development and deployment of smart grid technologies. Smart grid is a more robust application of

  7. Response to Request for Information titled "Addressing Policy and

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Logistical Challenges to Smart Grid Implementation" | Department of Energy to Request for Information titled "Addressing Policy and Logistical Challenges to Smart Grid Implementation" Response to Request for Information titled "Addressing Policy and Logistical Challenges to Smart Grid Implementation" Response to Request for Information titled "Addressing Policy and Logistical Challenges to Smart Grid Implementation." urrent smart grid initiatives are

  8. U.S. Energy Secretary Addresses International Atomic Energy Agency General

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Conference | Department of Energy Addresses International Atomic Energy Agency General Conference U.S. Energy Secretary Addresses International Atomic Energy Agency General Conference September 19, 2011 - 4:48pm Addthis VIENNA, AUSTRIA - U.S. Energy Secretary Steven Chu addressed the International Atomic Energy Agency's General Conference today in Vienna. Opening with a message from President Barack Obama, Secretary Chu highlighted the importance of safety and security in the nuclear

  9. GREET Model Expanded to Better Address Biofuel Life-Cycle Analysis Research

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Questions | Department of Energy GREET Model Expanded to Better Address Biofuel Life-Cycle Analysis Research Questions GREET Model Expanded to Better Address Biofuel Life-Cycle Analysis Research Questions November 23, 2015 - 2:57pm Addthis GREET Model Expanded to Better Address Biofuel Life-Cycle Analysis Research Questions The Greenhouse gases, Regulated Emissions, and Energy use in Transportation (GREET) model allows researchers and analysts to fully evaluate the energy and emission

  10. GridWise Alliance: Smart Grid RFI: Addressing Policy and Logistical...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    reliability, flexibility, and efficiency of our electric grid. PDF icon GridWise Alliance: Smart Grid RFI: Addressing Policy and Logistical Challenges More Documents & ...

  11. Addressing the Challenges of RCCI Operation on a Light-Duty Multi...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ORNL and UW collaboration in evaluating and developing RCCI operation in fully built multi-cylinder engine to address hardware, aftertreatment, and control challenges PDF icon ...

  12. Comments of DRSG to DOE Smart Grid RFI: Addressing Policy and...

    Energy.gov [DOE] (indexed site)

    Department of Energy RFI Association of Home Appliance Manufacturers Comments on Smart Grid RFI ASHRAE draft regarding Smart Grid RFI: Addressing Policy and Logistical Challenges

  13. RE-SCHEDULED FROM JAN 22 TO JAN 28 - COLLOQUIUM: Addressing Big...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    MBG Auditorium RE-SCHEDULED FROM JAN 22 TO JAN 28 - COLLOQUIUM: Addressing Big Data Challenges in Simulation-based Science Professor Manish Parashar Rutgers University ...

  14. Keynote Address: Cristin Dorgelo, White House Office of Science and Technology Policy

    Energy.gov [DOE]

    Cristin Dorgelo, Assistant Director of Grand Challenges for The White House Office of Science and Technology Policy will deliver a keynote address.

  15. Jackie Chen to give keynote address at ISC High performance conference...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    at ISC High performance conference in Germany - Sandia Energy Energy Search Icon Sandia ... Jackie Chen to give keynote address at ISC High performance conference in Germany Home...

  16. The Lessons of Practice: Domestic Policy Reform as a Way to Address...

    OpenEI (Open Energy Information) [EERE & EIA]

    Lessons of Practice: Domestic Policy Reform as a Way to Address Climate Change Jump to: navigation, search Tool Summary LAUNCH TOOL Name: The Lessons of Practice: Domestic Policy...

  17. Galvin Electricity Initiative DOE RFI DOE RFI 2010-23251: Addressing...

    Energy Saver

    Galvin Electricity Initiative DOE RFI DOE RFI 2010-23251: Addressing Policy and Logistical Challenges to Smart Grid Implementation Galvin Electricity Initiative DOE RFI DOE RFI ...

  18. Addressing the Challenges of RCCI Operation on a Light-Duty Multi-Cylinder Engine

    Energy.gov [DOE]

    ORNL and UW collaboration in evaluating and developing RCCI operation in fully built multi-cylinder engine to address hardware, aftertreatment, and control challenges

  19. Genes and Genomics for Improving Energy Crops (Keynote Address - 2010 JGI User Meeting)

    ScienceCinema

    Pennell, Roger

    2016-07-12

    Roger Pennell, Vice President of Trait Development at Ceres, Inc., delivers a keynote address at the 5th Annual DOE JGI User Meeting on March 25, 2010

  20. Tungsten impurity transport experiments in Alcator C-Mod to address...

    Office of Scientific and Technical Information (OSTI)

    Tungsten impurity transport experiments in Alcator C-Mod to address high priority research and development for ITER Citation Details In-Document Search Title: Tungsten impurity ...

  1. U-237: Mozilla Firefox CVE-2012-1950 Address Bar URI Spoofing...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Addthis PROBLEM: Mozilla Firefox CVE-2012-1950 Address Bar URI Spoofing Vulnerability PLATFORM: Version(s): Mozilla Firefox 6 - 12 ABSTRACT: To exploit this issue, an attacker...

  2. miR-206 is down-regulated in breast cancer and inhibits cell proliferation through the up-regulation of cyclinD2

    SciTech Connect

    Zhou, Jing; Tian, Ye; Li, Juan; Lu, Binbin; Sun, Ming; Zou, Yanfen; Kong, Rong; Luo, Yanhong; Shi, Yongguo; Wang, Keming; Ji, Guozhong

    2013-04-05

    Highlights: ? miR-206 was downexpressed in tumor samples compared with matched normal samples. ? Enhanced expression of miR-206 could inhibit breast cancer growth in vitro. ? Luciferase confirmed miR-206 functions as an anti-oncogene by targeting cyclinD2. ? A reverse correlation between miR-206 and cyclinD2 in breast cancer was found. -- Abstract: MicroRNAs act as important gene regulators in human genomes, and their aberrant expression is linked to many malignancies. Aberrant expression of miR-206 has been frequently reported in cancer studies; however, the role and mechanism of its function in breast cancer remains unclear. Quantitative real-time PCR was performed to detect the relative expression levels of miR-206 in breast cancer and normal breast tissues. Lower expression of miR-206 in breast cancer tissues was associated with larger tumour size and a more advanced clinical stage. Further in vitro observations showed that the enforced expression of miR-206 in MCF-7 breast cancer cells inhibited cell growth by blocking the G1/S transition and suppressed cell proliferation and colony formation, implying that miR-206 functions as a tumour suppressor in the progression of breast cancer. Interestingly, Luciferase assays first revealed that miR-206 inhibited cyclinD2 expression by targeting two binding sites in the 3?-untranslated region of cyclinD2 mRNA. qRT-PCR and Western blot assays verified that miR-206 reduced cyclinD2 expression at both the mRNA and protein levels. A reverse correlation between miR-206 and cyclinD2 expression was noted in breast cancer tissues. Altogether, our results identify a crucial tumour suppressive role of miR-206 in the progression of breast cancer, at least partly via up-regulation of the expression of cyclinD2, and suggest that miR-206 might be a candidate prognostic predictor or an anticancer therapeutic target for breast cancer patients.

  3. MiR-138 promotes smooth muscle cells proliferation and migration in db/db mice through down-regulation of SIRT1

    SciTech Connect

    Xu, Juan; Li, Li; Yun, Hui-fang; Han, Ye-shan

    2015-08-07

    Background: Diabetic vascular smooth muscle cells (VSMCs) exhibit significantly increased rates of proliferation and migration, which was the most common pathological change in atherosclerosis. In addition, the study about the role for miRNAs in the regulation of VSMC proliferation is just beginning to emerge and additional miRNAs involved in VSMC proliferation modulation should be identified. Methods: The expression of miR-138 and SIRT1 were examined in SMCs separated from db/db mice and in SMC lines C-12511 exposed to high glucose with qRT-PCR and western blot. The regulation of miR-138 on the expression of SMCs was detected with luciferase report assay. VSMCs proliferation and migration assays were performed to examine the effect of miR-138 inhibitor on VSMCs proliferation and migration. Results: We discovered that higher mRNA level of miR-138 and reduced expression of SIRT1 were observed in SMCs separated from db/db mice and in SMC lines C-12511. Moreover, luciferase report assay showed that the activity of SIRT1 3′-UTR was highly increased by miR-138 inhibitor and reduced by miR-138 mimic. In addition, we examined that the up-regulation of NF-κB induced by high glucose in SMCs was reversed by resveratrol and miR-138 inhibitor. MTT and migration assays showed that miR-138 inhibitor attenuated the proliferation and migration of smooth muscle cells. Conclusion: In this study, we revealed that miR-138 might promote proliferation and migration of SMC in db/db mice through suppressing the expression of SIRT1. - Highlights: • Higher mRNA level of miR-138 was observed in SMCs from db/db mice. • The mRNA and protein level of SIRT1 in SMCs from db/db mice were greatly reduced. • miR-138 could regulate the expression of SIRT1 in SMCs. • SIRT1 overexpression reversed the up-regulation of acetylized p65 and NF-κB induced by high glucose. • MiR-138 inhibitor reversed VSMCs proliferation and migration induced by high glucose.

  4. miR-15a/16 Enhances Radiation Sensitivity of Non-Small Cell Lung Cancer Cells by Targeting the TLR1/NF-κB Signaling Pathway

    SciTech Connect

    Lan, Fengming; Yue, Xiao; Ren, Gang; Li, Hongqi; Ping, Li; Wang, Yingjie; Xia, Tingyi

    2015-01-01

    Purpose: Many miRNAs have been identified as essential issues and core determining factors in tumor radiation. Recent reports have demonstrated that miRNAs and Toll-like receptors could exert reciprocal effects to control cancer development in various ways. However, a novel role of miR-15a/16 in enhancing radiation sensitivity by directly targeting TLR1 has not been reported, to our knowledge. Methods and Materials: Bioinformatic analyses, luciferase reporter assay, biochemical assays, and subcutaneous tumor establishment were used to characterize the signaling pathways of miRNA-15a/16 in response to radiation treatment. Results: First, an inverse correlation between the expression of miR-15a/16 and TLR1 protein was revealed in non-small cell lung cancer (NSCLC) and normal lung tissues. Next, we corroborated that miR-15a/16 specifically bound to TLR1 3′UTR and inhibited the expression of TLR1 in H358 and A549 cells. Furthermore, miR-15a/16 downregulated the activity of the NF-κB signaling pathway through TLR1. In addition, overexpression of miR-15a/16 inhibited survival capability and increased radiation-induced apoptosis, resulting in enhancement of radiosensitivity in H358 and A549 cells. Finally, subcutaneous tumor bearing NSCLC cells in a nude mice model was established, and the results showed that combined groups (miR-15a/16 + radiation) inhibited tumor growth more significantly than did radiation alone. Conclusions: We mainly elucidate that miRNA-15a/16 can enhance radiation sensitivity by regulating the TLR1/NF-κB signaling pathway and act as a potential therapeutic approach to overcome radioresistance for lung cancer treatment.

  5. Recommendations to Address Power Reliability Concerns Raised as a Result of

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Pending Environmental Regulations for Electric Generation Stations | Department of Energy to Address Power Reliability Concerns Raised as a Result of Pending Environmental Regulations for Electric Generation Stations Recommendations to Address Power Reliability Concerns Raised as a Result of Pending Environmental Regulations for Electric Generation Stations Memorandum from the Electricity Advisory Committee to Secretary Chu and Assistant Secretary Patricia Hoffman on recommendations to

  6. 2016 Annual Merit Review and Peer Evaluation Plenary – Keynote Address (Text Version)

    Energy.gov [DOE]

    This is the text version of the 2016 Annual Merit Review and Peer Evaluation Meeting Plenary – Keynote Address video, which includes the keynote address by the Honorable Byron Dorgan, U.S. Senate (retired) and an introduction by David Friedman, Acting Assistant Secretary, Office of Energy Efficiency and Renewable Energy.

  7. St. Clair, MI Natural Gas Pipeline Imports From Canada (Million Cubic Feet)

    Energy Information Administration (EIA) (indexed site)

    Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 14,132 11,855 34,592 33,388 2000's 17,198 21,747 28,441 5,202 22,853 18,281 10,410 9,633 9,104 6,544 2010's 5,591 5,228 3,531 6,019 16,409 9,024 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Natural Gas Pipeline Imports by Point of Entry St. Clair, MI Natural

  8. Observation of Disappearance of Muon Neutrinos in the NuMI Beam

    SciTech Connect

    Pavlovic, Zarko

    2008-05-01

    The Main Injector Neutrino Oscillation Search (MINOS) is a two detector long-baseline neutrino experiment designed to study the disappearance of muon neutrinos. MINOS will test the vμ → vτ oscillation hypothesis and measure precisely Δm232 and sin223 oscillation parameters. The source of neutrinos for MINOS experiment is Fermilab's Neutrinos at the Main Injector (NuMI) beamline. The energy spectrum and the composition of the beam is measured at two locations, one close to the source and the other 735 km down-stream in the Soudan Mine Underground Laboratory in northern Minnesota. The precision measurement of the oscillation parameters requires an accurate prediction of the neutrino flux at the Far Detector. This thesis discusses the calculation of the neutrino flux at the Far Detector and its uncertainties. A technique that uses the Near Detector data to constrain the uncertainties in the calculation of the flux is described. The data corresponding to an exposure of 2.5 x 1020 protons on the NuMI target is presented and an energy dependent disappearance pattern predicted by neutrino oscillation hypotheses is observed in the Far Detector data. The fit to MINOS data, for given exposure, yields the best fit values for Δm$2\\atop{23}$ and sin223 to be (2.38$+0.20\\atop{-0.16}$) x 10-3 eV2/c4and 1.00-0.08, respectively.

  9. Validation of the MCNPX-PoliMi Code to Design a Fast-Neutron Multiplicity Counter

    SciTech Connect

    J. L. Dolan; A. C. Kaplan; M. Flaska; S. A. Pozzi; D. L. Chichester

    2012-07-01

    Many safeguards measurement systems used at nuclear facilities, both domestically and internationally, rely on He-3 detectors and well established mathematical equations to interpret coincidence and multiplicity-type measurements for verifying quantities of special nuclear material. Due to resource shortages alternatives to these existing He-3 based systems are being sought. Work is also underway to broaden the capabilities of these types of measurement systems in order to improve current multiplicity analysis techniques. As a part of a Material Protection, Accounting, and Control Technology (MPACT) project within the U.S. Department of Energy's Fuel Cycle Technology Program we are designing a fast-neutron multiplicity counter with organic liquid scintillators to quantify important quantities such as plutonium mass. We are also examining the potential benefits of using fast-neutron detectors for multiplicity analysis of advanced fuels in comparison with He-3 detectors and testing the performance of such designs. The designs are being developed and optimized using the MCNPX-PoliMi transport code to study detector response. In the full paper, we will discuss validation measurements used to justify the use of the MCNPX-PoliMi code paired with the MPPost multiplicity routine to design a fast neutron multiplicity counter with liquid scintillators. This multiplicity counter will be designed with the end goal of safeguarding advanced nuclear fuels. With improved timing qualities associated with liquid scintillation detectors, we can design a system that is less limited by nuclear materials of high activities. Initial testing of the designed system with nuclear fuels will take place at Idaho National Laboratory in a later stage of this collaboration.

  10. T-1025 IU SciBath-768 detector tests in MI-12

    SciTech Connect

    Tayloe, Rex; Cooper, R.; Garrison, L.; Thornton, T.; Rebenitsch, L.; DeJongh, Fritz; Loer, Benjamin; Ramberg, Erik; Yoo, Jonghee; /Fermilab

    2012-02-11

    This is a memorandum of understanding between the Fermi National Accelerator Laboratory (Fermilab) and the experimenters of Department of Physics and Center for Exploration of Energy and Matter, Indiana University, who have committed to participate in detector tests to be carried out during the 2012 Fermilab Neutrino program. The memorandum is intended solely for the purpose of recording expectations for budget estimates and work allocations for Fermilab, the funding agencies and the participating institutions. it reflects an arrangement that currently is satisfactory to the parties; however, it is recognized and anticipated that changing circumstances of the evolving research program will necessitate revisions. The parties agree to modify this memorandum to reflect such required adjustments. Actual contractual obligations will be set forth in separate documents. The experimenters propsoe to test their prototype 'SciBat-768' detector in the MI-12 building for 3 months (February-April) in Spring 2012. The major goal of this effort is to measure or limit the flux of beam-induced neutrons in a far-off-axis (> 45{sup o}) location of the Booster Neutrino Beamline (BNB). This flux is of interest for a proposed coherent neutral-current neutrino-argon elastic scattering experiment. A second goal is to collect more test data for the SciBath-768 to enable better understanding and calibration of the device. The SciBath-768 detector successfully ran for 3 months in the MINOS Underground Area in Fall 2011 as testbeam experiment T-1014 and is currently running above ground in the MINOS service building. For the run proposed here, the experiments are requesting: space in MI-12 in which to run the SciBath detector during February-April 2012 while the BNB is operating; technical support to help with moving the equipment on site; access to power, internet, and accelerator signals; and a small office space from which to run and monitor the experiment.

  11. 1414 Prince Street

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ... event. While none of these programs meets the criteria of a National Power Transformer Reserve it is NASEO's belief that there is an opportunity for DOE, working in coordination ...

  12. Complete Streets Resources

    Energy.gov [DOE]

    While transportation efficiency policies are often implemented under local governments, national and state programs can play supportive roles in reducing vehicle miles traveled. Find complete...

  13. Pecan Street Project

    Office of Energy Efficiency and Renewable Energy (EERE)

    Slides presented in the "What’s Working in Residential Energy Efficiency Upgrade Programs Conference - Promising Approaches and Lessons Learned" on May 20, 2011 in Washington, D.C.

  14. MiR-520b suppresses proliferation of hepatoma cells through targeting ten-eleven translocation 1 (TET1) mRNA

    SciTech Connect

    Zhang, Weiying; Lu, Zhanping; Gao, Yuen; Ye, Lihong; Song, Tianqiang; Zhang, Xiaodong

    2015-05-08

    Accumulating evidence indicates that microRNAs are able to act as oncogenes or tumor suppressor genes in human cancer. We previously reported that miR-520b was down-regulated in hepatocellular carcinoma (HCC) and its deregulation was involved in hepatocarcinogenesis. In the present study, we report that miR-520b suppresses cell proliferation in HCC through targeting the ten-eleven translocation 1 (TET1) mRNA. Notably, we identified that miR-520b was able to target 3′-untranslated region (3′UTR) of TET1 mRNA by luciferase reporter gene assays. Then, we revealed that miR-520b was able to reduce the expression of TET1 at the levels of mRNA and protein using reverse transcription-polymerase chain reaction and Western blotting analysis. In terms of function, 5-ethynyl-2-deoxyuridine (EdU) incorporation and colony formation assays demonstrated that the forced miR-520b expression remarkably inhibited proliferation of hepatoma cells, but TET1 overexpression could rescue the inhibition of cell proliferation mediated by miR-520b. Furthermore, anti-miR-520b enhanced proliferation of hepatoma cells, whereas silencing of TET1 abolished anti-miR-520b-induced acceleration of cell proliferation. Then, we validated that the expression levels of miR-520b were negatively related to those of TET1 mRNA in clinical HCC tissues. Thus, we conclude that miR-520b depresses proliferation of liver cancer cells through targeting 3′UTR of TET1 mRNA. Our finding provides new insights into the mechanism of hepatocarcinogenesis. - Highlights: • TET1 is a novel target gene of miR-520b. • TET1 is upregulated in clinical HCC tissues. • MiR-520b is negatively correlated with TET1 in clinical HCC tissues. • MiR-520b depresses the proliferation of HCC cells through targeting TET1 mRNA.

  15. Second Five-Year Plan to Address Uranium Contamination in the Navajo Nation

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    | Department of Energy Second Five-Year Plan to Address Uranium Contamination in the Navajo Nation Second Five-Year Plan to Address Uranium Contamination in the Navajo Nation April 3, 2015 - 4:31pm Addthis What does this project do? Goal 1. Protect human health and the environment. Federal agencies recently completed a second Five-Year Plan to address uranium contamination on the Navajo Nation, which follows a progress report on the first plan that was initiated in January 2007. Contributing

  16. Secretary Chu to Address the Winter Meeting of the U.S. Conference of

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Mayors | Department of Energy to Address the Winter Meeting of the U.S. Conference of Mayors Secretary Chu to Address the Winter Meeting of the U.S. Conference of Mayors January 19, 2011 - 12:00am Addthis WASHINGTON, D.C. - US Energy Secretary Steven Chu will address the 79th winter meeting of the U.S. Conference of Mayors. Secretary Chu will attend the Energy Standing Committee session of the conference where he will discuss the importance of clean energy to our economic competitiveness.

  17. RedSeal Comments on "Smart Grid RFI: Addressing Policy and Logistical

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Challenges. | Department of Energy RedSeal Comments on "Smart Grid RFI: Addressing Policy and Logistical Challenges. RedSeal Comments on "Smart Grid RFI: Addressing Policy and Logistical Challenges. RedSeal Comments on "Smart Grid RFI: Addressing Policy and Logistical Challenges. RedSeal's core technology is the ability to understand the access control of the network as a whole - not simply the behavior of a single device. RedSeal analyzes the interactions of firewalls,

  18. U.S.-China Clean Energy Research Center Issues Solicitation to Address the

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energy-Water Nexus | Department of Energy Clean Energy Research Center Issues Solicitation to Address the Energy-Water Nexus U.S.-China Clean Energy Research Center Issues Solicitation to Address the Energy-Water Nexus March 4, 2015 - 4:31pm Addthis News Media Contact 202 586 4940 DOENews@hq.doe.gov U.S.-China Clean Energy Research Center Issues Solicitation to Address the Energy-Water Nexus WASHINGTON - Today the U.S. Department of Energy (DOE) issued a $12.5 million Funding Opportunity

  19. April 30, 2008; HSS/Union Working Group Meeting to address training - Executive Summary

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    HSS/UNION MEETING TO ADDRESS TRAINING INTEGRATED EXECUTIVE SUMMARY AND FINAL ACTION LIST HSS and the labor unions who participated in the initial 2007 HSS Focus Group meetings agreed to a path forward in which various unions combined to form core working groups to address union identified issues by topical area. The following is a synthesis of actions/activities identified in the April 30 HSS/Union meeting to address training issues with focus in the areas of the development of DOE-wide HAMMER

  20. Energy levels of the electrons localized over the surface of an inert film with address electrodes

    SciTech Connect

    Petrin, A. B.

    2013-03-15

    The problem of searching for the potential energy and the energy spectrum of the electrons localized over the surface of a thin liquid or solid inert film due to address electrodes placed under the film is considered.

  1. When the Internet Runs Out of Addresses, It'll be IPv6 to the Rescue!

    Energy.gov [DOE]

    There are “only” 3.2 billion unique addresses available across the Internet and we are quickly approaching that limit. Find out what network engineers are doing to solve this problem.

  2. DOE to Address Small Businesses Barriers in Government Contracting at Waste Management Conference

    Energy.gov [DOE]

    PHOENIX – EM and the DOE Office of Small and Disadvantaged Business Utilization (OSDBU) are working to address barriers that hinder small businesses from competing for prime contracts for work in the Cold War cleanup program.

  3. RedSeal Comments on "Smart Grid RFI: Addressing Policy and Logistical...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    RedSeal Comments on "Smart Grid RFI: Addressing Policy and Logistical Challenges. RedSeal's core technology is the ability to understand the access control of the network as a ...

  4. DOE Seeks Input On Addressing Contractor Pension and Medical Benefits Liabilities

    Energy.gov [DOE]

    WASHINGTON, DC - The U.S. Department of Energy (DOE) today announced in the Federal Register that it is seeking public comment on how to address the increasing costs and liabilities of contractor...

  5. U-115: Novell GroupWise Client Address Book Processing Buffer...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    is vulnerable to an exploit where a malformed address book could cause heap memory corruption, which could lead to remote code execution under the privilege of the user that...

  6. Site Office Contracting Officer E-mail address Ames Site Office...

    National Nuclear Security Administration (NNSA)

    Site Office Contracting Officer E-mail address Ames Site Office Jackie York Jacquelyn.york@ch.doe.gov Argonne Site Office Jacquelyn York Jacquelyn.york@ch.doe.gov Brookhaven Site ...

  7. Energy-Intensive Processes Portfolio: Addressing Key Energy Challenges Across U.S. Industry

    SciTech Connect

    2011-03-07

    AMO is developing advanced technologies that cut energy use and carbon emissions in some of the most energy-intensive processes within U.S. manufacturing. The brochure describes the AMO R&D projects that address these challenges.

  8. Opportunities for Building America Research to Address Energy Upgrade Technical Challenges: HVAC, Envelope and IAQ (301)

    Energy.gov [DOE]

    Better Buildings Residential Network Peer Exchange Call Series: Opportunities for Building America Research to Address Energy Upgrade Technical Challenges: HVAC, Envelope and IAQ (301), call slides and discussion summary.

  9. Oil and Gas Company Oil and Gas Company Address Place Zip Website

    OpenEI (Open Energy Information) [EERE & EIA]

    Oil and Gas Company Address Place Zip Website Abu Dhabi National Oil Company Abu Dhabi National Oil Company Abu http www adnoc ae default aspx Al Furat Petroleum Company Al Furat...

  10. U.S. Leads International Collaborative to Address Wind Energy Development/Wildlife Challenges

    Energy.gov [DOE]

    The U.S. Department of Energy (DOE) is leading a new International Energy Agency (IEA) Wind Task to address concerns about the environmental effects of wind energy technology.

  11. Secretary Chu's Address to the IAEA General Conference in Vienna, Austria |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Address to the IAEA General Conference in Vienna, Austria Secretary Chu's Address to the IAEA General Conference in Vienna, Austria September 14, 2009 - 12:00am Addthis 53rd IAEA General Conference - As Prepared for Delivery Secretary Steven Chu Monday, September 14, 2009 Thank you, Madame President. Congratulations on your election as President of this Conference. I would also like to congratulate Ambassador Amano on his appointment as Director General. I pledge my

  12. Smart Grid Consortium, Response of New York State Smart Grid Addressing

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Policy and Logistical Challenges | Department of Energy Consortium, Response of New York State Smart Grid Addressing Policy and Logistical Challenges Smart Grid Consortium, Response of New York State Smart Grid Addressing Policy and Logistical Challenges It represents a unique public-private partnership of largely New York State utilities, authorities, universities, industrial companies, and institutions and research organizations which came together in a collaborative manner to facilitate

  13. AMO Deputy Director Addresses Water-Energy Nexus at 2016 Energy Efficiency

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Global Forum | Department of Energy Deputy Director Addresses Water-Energy Nexus at 2016 Energy Efficiency Global Forum AMO Deputy Director Addresses Water-Energy Nexus at 2016 Energy Efficiency Global Forum May 20, 2016 - 3:49pm Addthis From left to right: Moderator Ramola Musante, panelists Ron Voglewede, Bill Varley, Rob Ivester, and S. Raghupathy. From left to right: Moderator Ramola Musante, panelists Ron Voglewede, Bill Varley, Rob Ivester, and S. Raghupathy. Water is a part of every

  14. New York Independent System Operator, Smart Grid RFI: Addressing Policy and

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Logistical Challenges. | Department of Energy New York Independent System Operator, Smart Grid RFI: Addressing Policy and Logistical Challenges. New York Independent System Operator, Smart Grid RFI: Addressing Policy and Logistical Challenges. In response to the Department of Energy's (DOE) Request for Information regarding smart grid implementation listed in the September 17, 2010 Federal Register, the New York Independent System Operator, Inc. (NYISO) offers the attached white paper

  15. President Bush Highlights Energy in the State of the Union Address |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Highlights Energy in the State of the Union Address President Bush Highlights Energy in the State of the Union Address February 3, 2005 - 10:01am Addthis "To keep our economy growing, we also need reliable supplies of affordable, environmentally responsible energy. Nearly four years ago, I submitted a comprehensive energy strategy that encourages conservation, alternative sources, a modernized electricity grid, and more production here at home -- including safe,

  16. Galvin Electricity Initiative DOE RFI DOE RFI 2010-23251: Addressing Policy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    and Logistical Challenges to Smart Grid Implementation | Department of Energy Galvin Electricity Initiative DOE RFI DOE RFI 2010-23251: Addressing Policy and Logistical Challenges to Smart Grid Implementation Galvin Electricity Initiative DOE RFI DOE RFI 2010-23251: Addressing Policy and Logistical Challenges to Smart Grid Implementation The Galvin Electricity Initiative, a non-profit organization, has dedicated its resources to researching and developing both prototypes and policy reforms

  17. GridWise Alliance: Smart Grid RFI: Addressing Policy and Logistical

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Challenges | Department of Energy GridWise Alliance: Smart Grid RFI: Addressing Policy and Logistical Challenges GridWise Alliance: Smart Grid RFI: Addressing Policy and Logistical Challenges The GridWise Alliance is a coalition of over 150 companies, organizations, and academic institutions advocating for a smart grid for a more sustainable future. We are consensus-driven and technology neutral and do not advocate for specific platforms or technologies, but, rather, for policies that will

  18. Natural Gas Industry Comments on Smart Grid RFI: Addressing Policy and

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Logistical Challenges to Smart Grid | Department of Energy Natural Gas Industry Comments on Smart Grid RFI: Addressing Policy and Logistical Challenges to Smart Grid Natural Gas Industry Comments on Smart Grid RFI: Addressing Policy and Logistical Challenges to Smart Grid The undersigned members of the natural gas industry are pleased to submit for your consideration the following comments in response to the U.S. Department of Energy, Office of Electricity Delivery and Energy Reliability's

  19. HPC4Mfg: Pairing Bright Minds with Powerful Resources to Address Critical

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Challenges in Manufacturing | Department of Energy HPC4Mfg: Pairing Bright Minds with Powerful Resources to Address Critical Challenges in Manufacturing HPC4Mfg: Pairing Bright Minds with Powerful Resources to Address Critical Challenges in Manufacturing September 15, 2016 - 2:25pm Addthis A simulation of pressure applied to felt used to absorb water in a paper drying process is one of the projects that received funding from the Department of Energy. | <em>Photo courtesy of David

  20. Comments of DRSG to DOE Smart Grid RFI: Addressing Policy and Logistical

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Challenges | Department of Energy DRSG to DOE Smart Grid RFI: Addressing Policy and Logistical Challenges Comments of DRSG to DOE Smart Grid RFI: Addressing Policy and Logistical Challenges In light of the fact that smart grid deployments are moving forward with pace and at scale, DRSG advises the DOE against seeking to redefine the term "smart grid" as a semantic exercise, as such an effort would introduce delay, generate uncertainty, and likely prove counterproductive. DOE Smart

  1. Upcoming Webinars to Focus on Topics Addressed in the National Academies of

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Sciences' "Analytical Foundations for the Next Generation Electric Grid" Report | Department of Energy Upcoming Webinars to Focus on Topics Addressed in the National Academies of Sciences' "Analytical Foundations for the Next Generation Electric Grid" Report Upcoming Webinars to Focus on Topics Addressed in the National Academies of Sciences' "Analytical Foundations for the Next Generation Electric Grid" Report April 7, 2016 - 11:52am Addthis The National

  2. April 30, 2008; HSS/Union Working Group Meeting to address training … Meeting Summary

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    * * training. * area discussed. Center (NTC) National Training Center. * * * Conduct of Meeting. A 1. 2. 3. 4. HAMMER. HSS/UNION MEETING TO ADDRESS TRAINING DRAFT MEETING SUMMARY Introductory Remarks. Glenn Podonsky made the following points: More than a dialogue, the intent of HSS is to participate in a productive manner, to develop working relationships with the unions, to work the issues, identify actions, and institutionalize a process for addressing and resolving issues to improve worker

  3. The RNA-binding protein PCBP2 facilitates gastric carcinoma growth by targeting miR-34a

    SciTech Connect

    Hu, Cheng-En; Liu, Yong-Chao; Zhang, Hui-Dong; Huang, Guang-Jian

    2014-06-13

    Highlights: • PCBP2 is overexpressed in human gastric cancer. • PCBP2 high expression predicts poor survival. • PCBP2 regulates gastric cancer growth in vitro and in vivo. • PCBP2 regulates gastric cancer apoptosis by targeting miR-34a. - Abstract: Gastric carcinoma is the fourth most common cancer worldwide, with a high rate of death and low 5-year survival rate. However, the mechanism underling gastric cancer is still not fully understood. Here in the present study, we identify the RNA-binding protein PCBP2 as an oncogenic protein in human gastric carcinoma. Our results show that PCBP2 is up-regulated in human gastric cancer tissues compared to adjacent normal tissues, and that high level of PCBP2 predicts poor overall and disease-free survival. Knockdown of PCBP2 in gastric cancer cells inhibits cell proliferation and colony formation in vitro, whereas opposing results are obtained when PCBP2 is overexpressed. Our in vivo subcutaneous xenograft results also show that PCBP2 can critically regulate gastric cancer cell growth. In addition, we find that PCBP2-depletion induces apoptosis in gastric cancer cells via up-regulating expression of pro-apoptotic proteins and down-regulating anti-apoptotic proteins. Mechanically, we identify that miR-34a as a target of PCBP2, and that miR-34a is critically essential for the function of PCBP2. In summary, PCBP2 promotes gastric carcinoma development by regulating the level of miR-34a.

  4. Reprogrammable read only variable threshold transistor memory with isolated addressing buffer

    DOEpatents

    Lodi, Robert J.

    1976-01-01

    A monolithic integrated circuit, fully decoded memory comprises a rectangular array of variable threshold field effect transistors organized into a plurality of multi-bit words. Binary address inputs to the memory are decoded by a field effect transistor decoder into a plurality of word selection lines each of which activates an address buffer circuit. Each address buffer circuit, in turn, drives a word line of the memory array. In accordance with the word line selected by the decoder the activated buffer circuit directs reading or writing voltages to the transistors comprising the memory words. All of the buffer circuits additionally are connected to a common terminal for clearing all of the memory transistors to a predetermined state by the application to the common terminal of a large magnitude voltage of a predetermined polarity. The address decoder, the buffer and the memory array, as well as control and input/output control and buffer field effect transistor circuits, are fabricated on a common substrate with means provided to isolate the substrate of the address buffer transistors from the remainder of the substrate so that the bulk clearing function of simultaneously placing all of the memory transistors into a predetermined state can be performed.

  5. Addressing environmental justice under the National Environment Policy Act at Sandia National Laboratories/New Mexico

    SciTech Connect

    Cohen, T.M.; Bleakly, D.R.

    1997-04-01

    Under Executive Order 12898, Federal Actions to Address Environmental Justice in Minority Populations and Low-Income Populations, the Department of Energy (DOE) and Sandia National Laboratories New Mexico (SNL) are required to identify and address, as appropriate, disproportionately high, adverse human health or environmental effects of their activities on minority and low-income populations. The National Environmental Policy Act (NEPA) also requires that environmental justice issues be identified and addressed. This presents a challenge for SNL because it is located in a culturally diverse area. Successfully addressing potential impacts is contingent upon accurately identifying them through objective analysis of demographic information. However, an effective public participation process, which is necessarily subjective, is also needed to understand the subtle nuances of diverse populations that can contribute to a potential impact, yet are not always accounted for in a strict demographic profile. Typically, there is little or no coordination between these two disparate processes. This report proposes a five-step method for reconciling these processes and uses a hypothetical case study to illustrate the method. A demographic analysis and community profile of the population within 50 miles of SNL were developed to support the environmental justice analysis process and enhance SNL`s NEPA and public involvement programs. This report focuses on developing a methodology for identifying potentially impacted populations. Environmental justice issues related to worker exposures associated with SNL activities will be addressed in a separate report.

  6. Ginsenoside-Rg{sub 1} induces angiogenesis by the inverse regulation of MET tyrosine kinase receptor expression through miR-23a

    SciTech Connect

    Kwok, Hoi-Hin; Chan, Lai-Sheung; Poon, Po-Ying; Yue, Patrick Ying-Kit; Wong, Ricky Ngok-Shun

    2015-09-15

    Therapeutic angiogenesis has been implicated in ischemic diseases and wound healing. Ginsenoside-Rg{sub 1} (Rg{sub 1}), one of the most abundant active components of ginseng, has been demonstrated as an angiogenesis-stimulating compound in different models. There is increasing evidence implicating microRNAs (miRNAs), a group of non-coding RNAs, as important regulators of angiogenesis, but the role of microRNAs in Rg{sub 1}-induced angiogenesis has not been fully explored. In this report, we found that stimulating endothelial cells with Rg{sub 1} could reduce miR-23a expression. In silico experiments predicted hepatocyte growth factor receptor (MET), a well-established mediator of angiogenesis, as the target of miR-23a. Transfection of the miR-23a precursor or inhibitor oligonucleotides validated the inverse relationship of miR-23a and MET expression. Luciferase reporter assays further confirmed the interaction between miR-23a and the MET mRNA 3′-UTR. Intriguingly, ginsenoside-Rg{sub 1} was found to increase MET protein expression in a time-dependent manner. We further demonstrated that ginsenoside-Rg{sub 1}-induced angiogenic activities were indeed mediated through the down-regulation of miR-23a and subsequent up-regulation of MET protein expression, as confirmed by gain- and loss-of-function angiogenic experiments. In summary, our results demonstrated that ginsenoside-Rg{sub 1} could induce angiogenesis by the inverse regulation of MET tyrosine kinase receptor expression through miR-23a. This study has broadened our understanding of the non-genomic effects of ginsenoside-Rg{sub 1,} and provided molecular evidence that warrant further development of natural compound as novel angiogenesis-promoting therapy. - Highlights: • Therapeutic angiogenesis has been implicated in ischemic diseases and wound healing. • Ginsenoside-Rg{sub 1} (Rg{sub 1}) has been demonstrated as an angiogenesis-stimulating compound. • We found that Rg{sub 1} induces angiogenesis by

  7. Analysis of the hydraulic data from the MI fracture zone at the Grimsel Rock Laboratory, Switzerland

    SciTech Connect

    Davey, A.; Karasaki, K.; Long, J.C.S.; Landsfeld, M.; Mensch, A.; Martel, S.J.

    1989-10-01

    One of the major problems in analyzing flow and transport in fractured rock is that the flow may be largely confined to a poorly connected network of fractures. In order to overcome some of this problem, Lawrence Berkeley Laboratory (LBL) has been developing a new type of fracture hydrology model called an equivalent discontinuum model. In this model the authors represent the discontinuous nature of the problem through flow on a partially filled lattice. A key component in constructing an equivalent discontinuum model from this lattice is removing some of the conductive elements such that the system is partially connected in the same manner as the fracture network. This is done through a statistical inverse technique called simulated annealing. The fracture network model is annealed by continually modifying a base model, or template such that the modified systems behave more and more like the observed system. In order to see how the simulated annealing algorithm works, the authors have developed a series of synthetic real cases. In these cases, the real system is completely known so that the results of annealing to steady state data can be evaluated absolutely. The effect of the starting configuration has been studied by varying the percent of conducting elements in the initial configuration. Results have shown that the final configurations converge to about the same percentage of conducting elements. An example using Nagra field data from the Migration Experiment (MI) at Grimsel Rock Laboratory in Switzerland is also analyzed. 24 refs., 33 figs., 3 tabs.

  8. A Flexible Baseline Design for the Advanced High Temperature Reactor Using Metallic Internals (AHTR-MI)

    SciTech Connect

    Peterson, Per F.; Haihua, Zhao

    2006-07-01

    The Advanced High Temperature Reactor (AHTR) is a novel reactor concept that uses clean liquid fluoride salts as a high temperature primary coolant for conventional graphite matrix, coated particle fuels. The very large volumetric heat capacity and excellent natural circulation heat transfer provided by liquid salts enables the design of high-temperature reactors with passive safety features and thermal powers ranging from 2400 to 4000 MW(t). To make optimal use of existing design information, early AHTR designs were modeled upon the S-PRISM sodium pool-reactor design, but introduced an insulated reactor vessel. Subsequent work has shown that liquid-salt cooled systems share important similarities with pressurized water reactors, which use a closed primary loop. This article discusses the use of a closed primary loop immersed in a separate buffer salt tank, which permits the primary loop components to be fabricated from metallic materials (AHTR-MI). This approach may provide several key advantages over open loop approaches, including very large thermal inertia. (authors)

  9. Fast nanoscale addressability of nitrogen-vacancy spins via coupling to a dynamic ferromagnetic vortex

    DOE PAGES [OSTI]

    Wolf, M. S.; Badea, R.; Berezovsky, J.

    2016-06-14

    The core of a ferromagnetic vortex domain creates a strong, localized magnetic field, which can be manipulated on nanosecond timescales, providing a platform for addressing and controlling individual nitrogen-vacancy centre spins in diamond at room temperature, with nanometre-scale resolution. Here, we show that the ferromagnetic vortex can be driven into proximity with a nitrogen-vacancy defect using small applied magnetic fields, inducing significant nitrogen-vacancy spin splitting. We also find that the magnetic field gradient produced by the vortex is sufficient to address spins separated by nanometre-length scales. By applying a microwave-frequency magnetic field, we drive both the vortex and the nitrogen-vacancymore » spins, resulting in enhanced coherent rotation of the spin state. Lastly, we demonstrate that by driving the vortex on fast timescales, sequential addressing and coherent manipulation of spins is possible on ~ 100 ns timescales.« less

  10. Monocyte to macrophage differentiation-associated (MMD) targeted by miR-140-5p regulates tumor growth in non-small cell lung cancer

    SciTech Connect

    Li, Weina; He, Fei

    2014-07-18

    Highlights: • Expression of MMD is increased in lung cancer tissues. • Knockdown of MMD inhibits growth of A549 and LLC cells in vitro and in vivo. • MMD is a direct functional target of miR-140-5p. • MiR-140-5p/MMD axis regulates Erk1/2 signaling. - Abstract: Monocyte to macrophage differentiation-associated (MMD) is identified in macrophages as a gene associated with the differentiation from monocytes to macrophages. Recent microarray analysis for non-small cell lung cancer (NSCLC) suggests that MMD is an important signature associated with relapse and survival among patients with NSCLC. Therefore, we speculate that MMD likely plays a role in lung cancer. In this study, we found that the protein level of MMD was increased in lung cancer compared to benign lung tissues, and knockdown of MMD inhibited the growth of A549 and Lewis lung cancer cells (LLC) in vitro and in vivo. Integrated analysis demonstrated that MMD was a direct functional target of miR-140-5p. Furthermore, we found that miR-140-5p/MMD axis could affect the cell proliferation of lung cancer cells by regulating Erk signaling. Together, our results highlight the significance of miR-140-5p/MMD axis in lung cancer, and miR-140-5p/MMD axis could serve as new molecular targets for the therapy against lung cancer.

  11. Join @Energy for the 2016 State of the Union Address | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    @Energy for the 2016 State of the Union Address Join @Energy for the 2016 State of the Union Address January 11, 2016 - 11:10am Addthis Join us for live coverage of the State of the Union, starting at 9PM ET on Tuesday. | Image courtesy of Carly Wilkins. Join us for live coverage of the State of the Union, starting at 9PM ET on Tuesday. | Image courtesy of Carly Wilkins. Allison Lantero Allison Lantero Digital Content Specialist, Office of Public Affairs How can I participate? Follow along with

  12. Keynote Address to the American Council on Renewable Energy | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energy Address to the American Council on Renewable Energy Keynote Address to the American Council on Renewable Energy June 20, 2007 - 2:07pm Addthis Remarks Prepared for Energy Secretary Samuel W. Bodman Thank you, Michael, for that introduction and thank you all for coming. It is good to be in New York, back among the financial community. For those of you who don't know, when I left M.I.T - where I taught chemical engineering - to enter the business world I started out as a venture

  13. Secretary Moniz's Keynote Address at the ARPA-E Summit in Washington D.C.

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    -- As Delivered | Department of Energy Keynote Address at the ARPA-E Summit in Washington D.C. -- As Delivered Secretary Moniz's Keynote Address at the ARPA-E Summit in Washington D.C. -- As Delivered February 26, 2014 - 5:18pm Addthis Dr. Ernest Moniz Dr. Ernest Moniz Secretary of Energy Well, thank you, Dan (Poneman). As Dan indicated, we go back a ways and if you look at Secretaries and Deputy Secretaries and Acting Secretaries of the Department of Energy, I'm pretty sure that Dan is the

  14. Ames Laboratory to Lead New Research Effort to Address Shortages in Rare

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Earth and Other Critical Materials | Department of Energy Ames Laboratory to Lead New Research Effort to Address Shortages in Rare Earth and Other Critical Materials Ames Laboratory to Lead New Research Effort to Address Shortages in Rare Earth and Other Critical Materials January 9, 2013 - 12:13pm Addthis NEWS MEDIA CONTACT (202) 586-4940 WASHINGTON - The U.S. Department of Energy announced today that a team led by Ames Laboratory in Ames, Iowa, has been selected for an award of up to $120

  15. DOE Convenes Multi-stakeholder Process to Address Privacy for Data Enabled

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    by Smart Grid Technologies | Department of Energy Convenes Multi-stakeholder Process to Address Privacy for Data Enabled by Smart Grid Technologies DOE Convenes Multi-stakeholder Process to Address Privacy for Data Enabled by Smart Grid Technologies February 12, 2013 - 3:53pm Addthis DOE's Office of Electricy Delivery and Energy Reliability (OE) issued a notice of an open meeting on Tuesday, February 26, 2013 (9:30 a.m. to 4:30 p.m. ET) of the smart grid data privacy multi-stakeholder

  16. U.S. Department of Energy Initiates New Outreach Efforts to Address a

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Changing Wind Industry | Department of Energy Initiates New Outreach Efforts to Address a Changing Wind Industry U.S. Department of Energy Initiates New Outreach Efforts to Address a Changing Wind Industry March 31, 2014 - 10:12am Addthis The U.S. Department of Energy (DOE) recently announced the launch of WINDExchange, a national engagement and outreach initiative that marks a new era of DOE's involvement in wind energy. Building on the success of DOE's previous work in this area, the

  17. New Webinar Series to Address Climate Change Impacts in Indian Country |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Webinar Series to Address Climate Change Impacts in Indian Country New Webinar Series to Address Climate Change Impacts in Indian Country March 26, 2014 - 7:32pm Addthis On Thursday, April 3, the White House and eight federal agencies will launch a four-part webinar series focused on evaluating, assessing, and mitigating the impacts of climate change on U.S. tribal communities. The "Climate Change Impacts and Indian Country" series is sponsored by the White

  18. Keck Institute for Space Studies "Addressing the MARS ISRU Challenge"

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Workshop - JCAP Keck Institute for Space Studies "Addressing the MARS ISRU Challenge" Workshop Keck Institute for Space Studies "Addressing the MARS ISRU Challenge" Workshop Tue, Jun 28, 2016 3:30pm 15:30 Fri, Jul 1, 2016 4:30pm 16:30 California Institute of Technology Pasadena, CA USA Members of JCAP and JPL helped co-organize a workshop on the "production of oxygen and fuel from CO2 using sunlight", which was held at Caltech from June 28-July 1. More

  19. Microsoft Word - nfo-205rev0

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Birth Place of Birth (City and State) Citizenship E-Mail Address: Badge : Level of Clearance: Purpose of Visit: Company Name: Job Title: Business Street Address Residence Street ...

  20. Energy Department Assistant Secretary Patricia Hoffman Addresses 2011 FERC Reliability Technical Conference

    Energy.gov [DOE]

    Department of Energy Assistant Secretary for Electricity Delivery and Energy Reliability Patricia Hoffman today addressed the 2011 Federal Energy Regulatory Commission technical conference in Washington, D.C. In remarks prepared for delivery, Assistant Secretary Hoffman discussed recent evaluations of proposed Environmental Protection Agency (EPA) rules and the impact those rules could be expected to have on our nation’s electrical grid.

  1. NNSA Administrator Addresses the Next Generation of Nuclear Security Professionals: Part 2

    ScienceCinema

    Thomas D'Agostino

    2016-07-12

    Administrator Thomas DAgostino of the National Nuclear Security Administration addressed the next generation of nuclear security professionals during the opening session of todays 2009 Department of Energy (DOE) Computational Science Graduate Fellowship Annual Conference. Administrator DAgostino discussed NNSAs role in implementing President Obamas nuclear security agenda and encouraged the computing science fellows to consider careers in nuclear security.

  2. NNSA Administrator Addresses the Next Generation of Nuclear Security Professionals: Part 1

    SciTech Connect

    Thomas D'Agostino

    2009-07-14

    Administrator Thomas DAgostino of the National Nuclear Security Administration addressed the next generation of nuclear security professionals during the opening session of todays 2009 Department of Energy (DOE) Computational Science Graduate Fellowship Annual Conference. Administrator DAgostino discussed NNSAs role in implementing President Obamas nuclear security agenda and encouraged the computing science fellows to consider careers in nuclear security.

  3. NNSA Administrator Addresses the Next Generation of Nuclear Security Professionals: Part 2

    SciTech Connect

    Thomas D'Agostino

    2009-07-14

    Administrator Thomas DAgostino of the National Nuclear Security Administration addressed the next generation of nuclear security professionals during the opening session of todays 2009 Department of Energy (DOE) Computational Science Graduate Fellowship Annual Conference. Administrator DAgostino discussed NNSAs role in implementing President Obamas nuclear security agenda and encouraged the computing science fellows to consider careers in nuclear security.

  4. DOE NSF Partnership to Address Critical Challenges in Hydrogen Production from Solar Water Splitting

    Energy.gov [DOE]

    EERE and the National Science Foundation (NSF) announce a funding opportunity in the area of renewable hydrogen technology research and development, specifically addressing discovery and development of advanced materials systems and chemical proceesses for direct photochemical and/or thermochemical water splitting for application in the solar production of hydrogen fuel.

  5. NNSA Administrator Addresses the Next Generation of Nuclear Security Professionals: Part 1

    ScienceCinema

    Thomas D'Agostino

    2016-07-12

    Administrator Thomas DAgostino of the National Nuclear Security Administration addressed the next generation of nuclear security professionals during the opening session of todays 2009 Department of Energy (DOE) Computational Science Graduate Fellowship Annual Conference. Administrator DAgostino discussed NNSAs role in implementing President Obamas nuclear security agenda and encouraged the computing science fellows to consider careers in nuclear security.

  6. Challenges to be Addressed | U.S. DOE Office of Science (SC)

    Office of Science (SC)

    Challenges to be Addressed Advanced Scientific Computing Research (ASCR) ASCR Home About Research Applied Mathematics Computer Science Exascale Tools Workshop Programming Challenges Workshop Architectures I Workshop External link Architectures II Workshop External link Next Generation Networking Scientific Discovery through Advanced Computing (SciDAC) ASCR SBIR-STTR Facilities Science Highlights Benefits of ASCR Funding Opportunities Advanced Scientific Computing Advisory Committee (ASCAC)

  7. Hepatitis B virus X protein mutant HBxΔ127 promotes proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT

    SciTech Connect

    Liu, Fabao; You, Xiaona; Chi, Xiumei; Wang, Tao; Ye, Lihong; Niu, Junqi; Zhang, Xiaodong

    2014-02-07

    Highlights: • Relative to wild type HBx, HBX mutant HBxΔ127 strongly enhances cell proliferation. • Relative to wild type HBx, HBxΔ127 remarkably up-regulates miR-215 in hepatoma cells. • HBxΔ127-elevated miR-215 promotes cell proliferation via targeting PTPRT mRNA. - Abstract: The mutant of virus is a frequent event. Hepatitis B virus X protein (HBx) plays a vital role in the development of hepatocellular carcinoma (HCC). Therefore, the identification of potent mutant of HBx in hepatocarcinogenesis is significant. Previously, we identified a natural mutant of the HBx gene (termed HBxΔ127). Relative to wild type HBx, HBxΔ127 strongly enhanced cell proliferation and migration in HCC. In this study, we aim to explore the mechanism of HBxΔ127 in promotion of proliferation of hepatoma cells. Our data showed that both wild type HBx and HBxΔ127 could increase the expression of miR-215 in hepatoma HepG2 and H7402 cells. However, HBxΔ127 was able to significantly increase miR-215 expression relative to wild type HBx in the cells. We identified that protein tyrosine phosphatase, receptor type T (PTPRT) was one of the target genes of miR-215 through targeting 3′UTR of PTPRT mRNA. In function, miR-215 was able to promote the proliferation of hepatoma cells. Meanwhile anti-miR-215 could partially abolish the enhancement of cell proliferation mediated by HBxΔ127 in vitro. Knockdown of PTPRT by siRNA could distinctly suppress the decrease of cell proliferation mediated by anti-miR-215 in HepG2-XΔ127/H7402-XΔ127 cells. Moreover, we found that anti-miR-215 remarkably inhibited the tumor growth of hepatoma cells in nude mice. Collectively, relative to wild type HBx, HBxΔ127 strongly enhances proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT. Our finding provides new insights into the mechanism of HBx mutant HBxΔ127 in promotion of proliferation of hepatoma cells.

  8. Addressing the Manufacturing Issues Associated with the use of Ceramic Materials for Diesel Engine Components.

    SciTech Connect

    McSpadden, SB

    2001-09-12

    This CRADA supports the objective of selecting appropriate ceramic materials for manufacturing several diesel engine components and addressing critical manufacturing issues associated with these components. Materials that were evaluated included several varieties of silicon nitride and stabilized zirconia. The critical manufacturing issues that were addressed included evaluation of the effect of grain size and the effect of the grinding process on mechanical properties, mechanical performance, reliability, and expected service life. The CRADA comprised four tasks: (1) Machining of Zirconia and Silicon Nitride Materials; (2) Mechanical Properties Characterization and Performance Testing; (3) Tribological Studies; and (4) Residual Stress Studies. Using instrumented equipment at the High Temperature Materials Laboratory (HTML) Machining and Inspection Research User Center (MIRUC), zirconia and silicon nitride materials were ground into simulated component geometries. These components were subsequently evaluated for mechanical properties, wear, and residual stress characteristics in tasks two, three, and four.

  9. Global Gathering Addresses PV Role in Energy Prosperity and Climate Change

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Mitigation | PV | NREL Global Gathering Addresses PV Role in Energy Prosperity and Climate Change Mitigation March 30, 2016 Scientists from the Energy Department's National Renewable Energy Laboratory (NREL), along with their counterparts from solar energy research institutes in Germany and Japan, gathered recently to discuss the future of photovoltaics (PV) and assess its contributions to increasing global prosperity, energy security and mitigation of climate change. The Global Alliance of

  10. Chapter VII: Addressing Environmental Aspects of TS&D Infrastructure

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    -36 QER Report: Energy Transmission, Storage, and Distribution Infrastructure | April 2015 Chapter VII: Addressing Environmental Aspects of TS&D Infrastructure QER Report: Energy Transmission, Storage, and Distribution Infrastructure | April 2015 8-1 Chapter VIII This chapter gives an overview of current and projected employment in and related to the energy sector and discusses programs to assist in meeting the demand for new workers going forward. The first section provides estimates of

  11. Recommendations for Addressing Axial Burnup in the PWR Burnup Credit Analyses

    SciTech Connect

    Wagner, J.C.

    2002-10-23

    This report presents studies performed to support the development of a technically justifiable approach for addressing the axial-burnup distribution in pressurized-water reactor (PWR) burnup-credit criticality safety analyses. The effect of the axial-burnup distribution on reactivity and proposed approaches for addressing the axial-burnup distribution are briefly reviewed. A publicly available database of profiles is examined in detail to identify profiles that maximize the neutron multiplication factor, k{sub eff}, assess its adequacy for PWR burnup credit analyses, and investigate the existence of trends with fuel type and/or reactor operations. A statistical evaluation of the k{sub eff} values associated with the profiles in the axial-burnup-profile database was performed, and the most reactive (bounding) profiles were identified as statistical outliers. The impact of these bounding profiles on k{sub eff} is quantified for a high-density burnup credit cask. Analyses are also presented to quantify the potential reactivity consequence of loading assemblies with axial-burnup profiles that are not bounded by the database. The report concludes with a discussion on the issues for consideration and recommendations for addressing axial burnup in criticality safety analyses using burnup credit for dry cask storage and transportation.

  12. Mitsubishi iMiEV: An Electric Mini-Car in NREL's Advanced Technology Vehicle Fleet (Fact Sheet)

    SciTech Connect

    Not Available

    2011-10-01

    This fact sheet highlights the Mitsubishi iMiEV, an electric mini-car in the advanced technology vehicle fleet at the National Renewable Energy Laboratory (NREL). In support of the U.S. Department of Energy's fast-charging research efforts, NREL engineers are conducting charge and discharge performance testing on the vehicle. NREL's advanced technology vehicle fleet features promising technologies to increase efficiency and reduce emissions without sacrificing safety or comfort. The fleet serves as a technology showcase, helping visitors learn about innovative vehicles that are available today or are in development. Vehicles in the fleet are representative of current, advanced, prototype, and emerging technologies.

  13. Addressing trend-related changes within cumulative effects studies in water resources planning

    SciTech Connect

    Canter, L.W.; Chawla, M.K.; Swor, C.T.

    2014-01-15

    Summarized herein are 28 case studies wherein trend-related causative physical, social, or institutional changes were connected to consequential changes in runoff, water quality, and riparian and aquatic ecological features. The reviewed cases were systematically evaluated relative to their identified environmental effects; usage of analytical frameworks, and appropriate models, methods, and technologies; and the attention given to mitigation and/or management of the resultant causative and consequential changes. These changes also represent important considerations in project design and operation, and in cumulative effects studies associated therewith. The cases were grouped into five categories: institutional changes associated with legislation and policies (seven cases); physical changes from land use changes in urbanizing watersheds (eight cases); physical changes from land use changes and development projects in watersheds (four cases); physical, institutional, and social changes from land use and related policy changes in river basins (three cases); and multiple changes within a comprehensive study of land use and policy changes in the Willamette River Basin in Oregon (six cases). A tabulation of 110 models, methods and technologies used in the studies is also presented. General observations from this review were that the features were unique for each case; the consequential changes were logically based on the causative changes; the analytical frameworks provided relevant structures for the studies, and the identified methods and technologies were pertinent for addressing both the causative and consequential changes. One key lesson was that the cases provide useful, “real-world” illustrations of the importance of addressing trend-related changes in cumulative effects studies within water resources planning. Accordingly, they could be used as an “initial tool kit” for addressing trend-related changes.

  14. Addressing a single spin in diamond with a macroscopic dielectric microwave cavity

    SciTech Connect

    Le Floch, J.-M.; Tobar, M. E.; Bradac, C.; Nand, N.; Volz, T.; Castelletto, S.

    2014-09-29

    We present a technique for addressing single nitrogen-vacancy (NV) center spins in diamond over macroscopic distances using a tunable dielectric microwave cavity. We demonstrate optically detected magnetic resonance (ODMR) for a single negatively charged NV center (NV{sup }) in a nanodiamond (ND) located directly under the macroscopic microwave cavity. By moving the cavity relative to the ND, we record the ODMR signal as a function of position, mapping out the distribution of the cavity magnetic field along one axis. In addition, we argue that our system could be used to determine the orientation of the NV{sup } major axis in a straightforward manner.

  15. RE-SCHEDULED FROM JAN 22 TO JAN 28 - COLLOQUIUM: Addressing Big Data

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Challenges in Simulation-based Science | Princeton Plasma Physics Lab 8, 2014, 4:00pm to 5:30pm Colloquia MBG Auditorium RE-SCHEDULED FROM JAN 22 TO JAN 28 - COLLOQUIUM: Addressing Big Data Challenges in Simulation-based Science Professor Manish Parashar Rutgers University Presentation: PDF icon Presentation Abstract: PDF icon COLL.01.28.14.pdf COLLOQUIUM RE-SCHEDULED FROM JAN. 22 TO JAN 28 Data-related challenges are quickly dominating computational and data-enabled sciences, and are

  16. SOFTWARE TOOLS THAT ADDRESS HAZARDOUS MATERIAL ISSUES DURING NUCLEAR FACILITY D and D

    SciTech Connect

    M. COURNOYER; R. GRUNDEMANN

    2001-03-01

    The 49-year-old Chemistry and Metallurgy Research (CMR) Facility is where analytical chemistry and metallurgical studies on samples of plutonium and nuclear materials are conduct in support of the Department of Energy's nuclear weapons program. The CMR Facility is expected to be decontaminated and decommissioned (D and D) over the next ten to twenty years. Over the decades, several hazardous material issues have developed that need to be address. Unstable chemicals must be properly reassigned or disposed of from the workspace during D and D operation. Materials that have critical effects that are primarily chronic in nature, carcinogens, reproductive toxin, and materials that exhibit high chronic toxicity, have unique decontamination requirements, including the decontrolling of areas where these chemicals were used. Certain types of equipment and materials that contain mercury, asbestos, lead, and polychlorinated biphenyls have special provisions that must be addressed. Utilization of commercially available software programs for addressing hazardous material issues during D and D operations such as legacy chemicals and documentation are presented. These user-friendly programs eliminate part of the tediousness associated with the complex requirements of legacy hazardous materials. A key element of this approach is having a program that inventories and tracks all hazardous materials. Without an inventory of chemicals stored in a particular location, many important questions pertinent to D and D operations can be difficult to answer. On the other hand, a well-managed inventory system can address unstable and highly toxic chemicals and hazardous material records concerns before they become an issue. Tapping into the institutional database provides a way to take advantage of the combined expertise of the institution in managing a cost effective D and D program as well as adding a quality assurance element to the program. Using laboratory requirements as a logic flow

  17. The following data/assumptions will better address the LLW differences between t

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    data/assumptions will better address the LLW differences between the LEU option and the LEU/Th option of Alternative 1. 1. There is 397 kg fissile ( 233 U and 235 U) in the HTGR fuel. 2. Based on past experience of LLW to Nevada National Security Site, it is expected that the maximum quantity of fissile in a Type B shipping container (CASTOR cask) will be restricted to 1 kg. To protect a 1 kg maximum, it is assumed that 900 grams would be the maximum in a CASTOR cask. Therefore, from a fissile

  18. Assessing strategies to address transition costs in a restructuring electricity industry

    SciTech Connect

    Baxter, L.; Hadley, S.; Hirst, E.

    1996-08-01

    Restructuring the US electricity industry has become the nation`s central energy issue for the 1990s. Restructuring proposals at the federal and state levels focus on more competitive market structures for generation and the integration of transmission within those structures. The proposed move to more competitive generation markets will expose utility costs that are above those experienced by alternative suppliers. Debate about these above-market, or transition, costs (e.g., their size,who will pay for them and how) has played a prominent role in restructuring proceedings. This paper presents results from a project to systematically assess strategies to address transition costs exposed by restructuring the electricity industry.

  19. COMPUTER SIMULATIONS TO ADDRESS PU-FE EUTECTICISSUE IN 3013 STORAGE VESSEL

    SciTech Connect

    Gupta, N; Allen Smith, A

    2007-03-06

    On November 22, 2005, the Manager of the Plutonium Finishing Plant (PFP) in Richland, WA issued an Occurrence Report involving a potential Pu-Fe eutectic failure mechanism for the stainless steel (SS) 3013 cans containing plutonium (Pu) metal. Four additional reports addressed nuclear safety concerns about the integrity of stainless steel containers holding plutonium during fire scenarios. The reports expressed a belief that the probability and consequences of container failure due to the formation of a plutonium-iron eutectic alloy had been overlooked. Simplified thermal model to address the Pu-Fe eutectic concerns using axisymmetric model similar to the models used in the 9975 SARP were performed. The model uses Rocky Flats configuration with 2 stacked Pu buttons inside a 3013 assembly. The assembly has an outer can, an inner can, and a convenience can, all stainless steel. The boundary conditions are similar to the regulatory 30 minutes HAC fire analyses. Computer simulations of the HAC fire transients lasting 4 hours of burn time show that the interface between the primary containment vessel and the Pu metal in the 9975 package will not reach Pu-Fe eutectic temperature of 400 C.

  20. Enabling a Highly-Scalable Global Address Space Model for Petascale Computing

    SciTech Connect

    Apra, Edoardo; Vetter, Jeffrey S; Yu, Weikuan

    2010-01-01

    Over the past decade, the trajectory to the petascale has been built on increased complexity and scale of the underlying parallel architectures. Meanwhile, software de- velopers have struggled to provide tools that maintain the productivity of computational science teams using these new systems. In this regard, Global Address Space (GAS) programming models provide a straightforward and easy to use addressing model, which can lead to improved produc- tivity. However, the scalability of GAS depends directly on the design and implementation of the runtime system on the target petascale distributed-memory architecture. In this paper, we describe the design, implementation, and optimization of the Aggregate Remote Memory Copy Interface (ARMCI) runtime library on the Cray XT5 2.3 PetaFLOPs computer at Oak Ridge National Laboratory. We optimized our implementation with the flow intimation technique that we have introduced in this paper. Our optimized ARMCI implementation improves scalability of both the Global Arrays (GA) programming model and a real-world chemistry application NWChem from small jobs up through 180,000 cores.