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Sample records for mi ny lake

  1. DOE - Office of Legacy Management -- Niagara Falls Storage Site NY - NY 17

    Office of Legacy Management (LM)

    Considered Sites > Niagara Falls Storage Site NY - NY 17 FUSRAP Considered Sites Niagara Falls Storage Site, NY Alternate Name(s): Lake Ontario Ordnance Works (LOOW) Niagara Falls Storage Site (NFSS) DOE-Niagara Falls Storage Site NY.17-1 NY.17-3 Location: Lewiston, New York NY.17-5 Historical Operations: Stored, shipped, and buried radioactive equipment and waste for MED and AEC containing uranium, radium, and thorium. Contains Interim Waste Containment Structure. NY.17-1 NY.17-2 NY.17-14

  2. Sylvania Corporation, Hicksville, NY and Bayside NY | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Sylvania Corporation, Hicksville, NY and Bayside NY Sylvania Corporation, Hicksville, NY and Bayside NY Sylvania Corporation, Hicksville, NY and Bayside NY. Memorandumtoreader.pd...

  3. Sylvania Corporation, Hicksville, NY and Bayside, NY | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    NY Sylvania Corporation, Hicksville, NY and Bayside, NY Sylvania Corporation, Hicksville, NY and Bayside, NY, July 8, 2004. sylvaniacorporation.pdf PDF icon Sylvania Corporation, ...

  4. Sylvania Corporation, Hicksville, NY and Bayside, NY - Addendum...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    NY - Addendum to July 8, 2004 Sylvania Corporation, Hicksville, NY and Bayside, NY - Addendum to July 8, 2004 Sylvania Corporation, Hicksville, NY and Bayside, NY - Addendum to ...

  5. Sylvania Corporation, Hicksville, NY and Bayside, NY - Addendum to July

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    8, 2004 | Department of Energy NY - Addendum to July 8, 2004 Sylvania Corporation, Hicksville, NY and Bayside, NY - Addendum to July 8, 2004 Sylvania Corporation, Hicksville, NY and Bayside, NY - Addendum to July 8, 2004, additional_sylvania.pdf memorandum Date: October 6, 2004 Reply to Attn of: Department of Energy Headquarters FOIA/Privacy Act Office Sylvania Corporation, Hicksville, NY and Bayside, NY - Addendum to July 8, 2004 (11.46 KB) More Documents & Publications Index2.doc

  6. NY-Sun Loan Program

    Office of Energy Efficiency and Renewable Energy (EERE)

    NY-Sun loan program is part of broader NY-Sun Initiative program to accelerate the use of solar PV across the State. In addition to cash incentives, NY-Sun Initiative also provides State sponsored...

  7. Renewable Heat NY

    Office of Energy Efficiency and Renewable Energy (EERE)

    NOTE: On August 2015, NYSERDA increased the incentive levels for technologies offered under the Renewable Heat NY program. In general, new incentives fund up to 45% of the total project cost, which...

  8. Category:Syracuse, NY | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    KB SVLargeOffice Syracuse NY Consolidated Edison Co-NY Inc.png SVLargeOffice Syracuse... 68 KB SVMediumOffice Syracuse NY Consolidated Edison Co-NY Inc.png SVMediumOffice...

  9. Category:Rochester, NY | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    in this category, out of 16 total. SVFullServiceRestaurant Rochester NY Consolidated Edison Co-NY Inc.png SVFullServiceRestauran... 70 KB SVQuickServiceRestaurant Rochester NY...

  10. DOE - Office of Legacy Management -- Buffalo NY Site - NY 54

    Office of Legacy Management (LM)

    ... 19, 1992 NY.54-3 - U.S. Government (Tonawanda Sub-Office) Memorandum; Hershman to Smith; Subject: Transmittal of Monthly Progress Report for October, October 21, 1952. ...

  11. NY Solar Map and Portal

    Energy.gov [DOE]

    The NY Solar Map and Portal helps New Yorkers determine the advantages of going solar by providing detailed and localized information about a customer's solar potential. Supported by the SunShot...

  12. AER NY Kinetics LLC | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    AER NY Kinetics LLC Jump to: navigation, search Name: AER NY Kinetics LLC Address: PO Box 585 21 Entrance Avenue Place: Ogdensburg Zip: 13669 Region: United States Sector: Marine...

  13. Western NY Energy LLC | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    search Name: Western NY Energy LLC Place: Mount Morris, New York Zip: 14510 Product: Bioethanol producer. References: Western NY Energy LLC1 This article is a stub. You can help...

  14. Upstate NY Power Corp | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    NY Power Corp Jump to: navigation, search Name: Upstate NY Power Corp Place: West Seneca, New York Zip: 14224-3454 Sector: Wind energy Product: Developer of clean energy projects...

  15. Great Lakes Energy Coop | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Logo: Great Lakes Energy Coop Name: Great Lakes Energy Coop Address: PO Box 70 Place: Boyne City, MI Zip: 49712 Service Territory: Michigan Phone Number: 1-800-678-0411 Website:...

  16. Superfund record of decision (EPA Region 5): Torch Lake Site, Operable Units 1 and 3, Houghton County, MI. (First remedial action), September 1992

    SciTech Connect

    Not Available

    1992-09-30

    The 2,700-acre Torch Lake site is a copper milling and smelting facility in Houghton County, Michigan. The lake, a repository of milling wastes, served as the waterway for transportation to support the mining industry. In the late 1960's, copper milling ceased. In 1972, a discharge of 27,000 gallons of cupric ammonium carbonate leaching liquor occurred into the north end of Torch Lake from the storage vats at the Lake Linden Leaching Plant. The state investigated the spill and found no harmful effects associated with the spill; however, discoloration of several acres of lake bottom was noted. The ROD addresses removal of debris, surface tailings, and slag pile/beach, and disposal of drums on the western shore of the site, as OU1, and remediation of slag pile locations through the mid-Keweenaw Peninsula, as OU3. The primary contaminants of concern affecting the soil, debris, and slag pile/beach are organics, including PAHs; and metals, including arsenic, chromium, lead, and copper. The selected remedial action for the site are included.

  17. NY_8076404_nightfall.jpg | OSTI, US Dept of Energy Office of Scientific and

    Office of Scientific and Technical Information (OSTI)

    Technical Information NY_8076404_nightfall

  18. NY Green Bank | Department of Energy

    Energy.gov [DOE] (indexed site)

    sector to address and alleviate market and financial barriers preventing a thriving clean energy marketplace. NY Green Bank does not accept deposits or offer retail loans, and...

  19. NY

    Office of Legacy Management (LM)

    ... Uraniun-23 8 Thoriun-234 Protact:.nlun-23 4 Uranlurn-234 Thortum-230 Radiuru-226 Radon-222 Polonium-21 8 L e a d - 2 1 4 Bismuth-2 1 4 Poloniuro-214 L e a d - 2 1 0 Bisnuth-21 0 ...

  20. DOE - Office of Legacy Management -- Floyd Bennett Field - NY...

    Office of Legacy Management (LM)

    Designated Name: Not Designated Alternate Name: Naval Air Station NY.0-11-1 Location: Buildings 67 and 69 , Brooklyn , New York NY.0-11-1 Evaluation Year: 1987 NY.0-11-1 Site ...

  1. New York Battery and Energy Storage Technology Consortium NY...

    OpenEI (Open Energy Information) [EERE & EIA]

    Battery and Energy Storage Technology Consortium NY BEST Jump to: navigation, search Name: New York Battery and Energy Storage Technology Consortium (NY-BEST) Place: Albany, New...

  2. US MidAtl NY Site Consumption

    Annual Energy Outlook

    ... Yes Yes No No 0% 20% 40% 60% 80% 100% US NY No Car CAR IS PARKED WITHIN 20 FT OF ELECTRICAL OUTLET More highlights from RECS on housing characteristics and energy-related ...

  3. US MidAtl NY Site Consumption

    Energy Information Administration (EIA) (indexed site)

    MidAtl NY Site Consumption million Btu $0 $500 $1,000 $1,500 $2,000 $2,500 $3,000 US MidAtl NY Expenditures dollars ALL ENERGY average per household (excl. transportation) 0 2,000 4,000 6,000 8,000 10,000 12,000 US MidAtl NY Site Consumption kilowatthours $0 $250 $500 $750 $1,000 $1,250 $1,500 US MidAtl NY Expenditures dollars ELECTRICITY ONLY average per household * New York households consume an average of 103 million Btu per year, 15% more than the U.S. average. * Electricity consumption in

  4. DOE - Office of Legacy Management -- Syracuse University - NY...

    Office of Legacy Management (LM)

    work with uranium oxide and the precipitation of thorium iodate from homogeneous solution. ... Radioactive Materials Handled: Uranium, Thorium NY.29-3 NY.29-4 Radiological Survey(s): ...

  5. DOE - Office of Legacy Management -- Markite Co - NY 49

    Office of Legacy Management (LM)

    Site Operations: Conducted experiments with very small amounts of uranium and thorium. ... Radioactive Materials Handled: Uranium, Thorium NY.49-2 NY.49-3 Radiological Survey(s): ...

  6. DOE - Office of Legacy Management -- Frederick Flader Inc - NY...

    Office of Legacy Management (LM)

    consulting services and supported development of auxiliary equipment related to nuclear power NY.0-13-1 Site Disposition: Eliminated NY.0-13-1 Radioactive Materials Handled: None ...

  7. DOE - Office of Legacy Management -- ACF Industries Inc - NY...

    Office of Legacy Management (LM)

    Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: American Car and Foundry Company NY.13-2 Location: Buffalo , New York NY.13-2 Evaluation ...

  8. DOE - Office of Legacy Management -- Buflovak Co - NY 56

    Office of Legacy Management (LM)

    NY.56-1 Site Disposition: Eliminated - Possibility for contamination considered remote due to scope of tests conducted and indication of cleanup operations after tests NY.56-1 ...

  9. DOE - Office of Legacy Management -- New York University - NY...

    Office of Legacy Management (LM)

    Also see Documents Related to NEW YORK UNIVERSITY NY.50-1 - DOE MemorandumChecklist; Young to File; Subject: Elimination Recommendation; November 27, 1987 NY.50-2 - AEC...

  10. DOE - Office of Legacy Management -- Seneca Army Depot - NY 11

    Office of Legacy Management (LM)

    NY.11-2 NY.11-3 Site Operations: Eleven bunkers were used to store approximately 2,000 drums of pitchblende ore in the early 1940's. The bunkers were returned to munitions storage...

  11. DOE - Office of Legacy Management -- Love Canal - NY 24

    Office of Legacy Management (LM)

    NY.24-1 - DOE MemorandumChecklist; Jones to File; Subject: Elimination - Love Canal; April 30, 1987 NY.24-3 - Report; Smith to Fink; Preliminary Report of New York State Assembly ...

  12. DOE - Office of Legacy Management -- Hooker Chemical Co - NY...

    Office of Legacy Management (LM)

    Company) Niagara Falls, New York September 30, 1985 NY.05-3 - Report, Formerly Utilized MEDAEC Sites Remedial Action Program Radiological Survey of the Hooker Chemical ...

  13. DOE - Office of Legacy Management -- Sacandaga - NY 51

    Office of Legacy Management (LM)

    Designated Name: Not Designated Alternate Name: None Location: 823 Sacandaga Road , ... Remedial Action Performed at the Sacandaga Road Site Property in Glenville NY; December ...

  14. NY-Sun PV Incentive Program (Residential and Small Business)...

    Energy.gov [DOE] (indexed site)

    NY-Sun CommercialIndustrial Incentive program that offers incentives for grid connected PV systems larger than 200 KW. The New York State Energy Research and Development...

  15. DOE - Office of Legacy Management -- Fordham University - NY...

    Office of Legacy Management (LM)

    FUSRAP Also see Documents Related to Fordham University NY.0-12-1 - Aerospace Letter; Young to Wallo; Subject: Elimination Recommendation -- Colleges and Universities; September...

  16. DOE - Office of Legacy Management -- Columbia University - NY...

    Office of Legacy Management (LM)

    development -- nuclear chain reaction (fission) and gaseous diffusion during the 1940s. ... remediation efforts NY.03-1 Radioactive Materials Handled: Yes Primary Radioactive ...

  17. Business Council of Westchester County (NY) | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    101 Place: White Plains, New York Zip: 10604 Region: Northeast - NY NJ CT PA Area Sector: Services Product: Green Power Marketer Website: www.westchesterny.org Coordinates:...

  18. DOE - Office of Legacy Management -- Memorial Hospital - NY 0...

    Office of Legacy Management (LM)

    Conducted studies for MED including a "Physiological Study of Sunbath Treatments." Involvement with radioactive materials unknown. NY.0-16-1 Site Disposition: Eliminated -...

  19. Los Alamos technology to be featured on CSI: NY

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Los Alamos technology to be featured on CSI: NY The multipurpose "sampler gun" rapidly ... Mountain Daylight Time April 2 on CBS. The multipurpose "sampler gun" rapidly collects and ...

  20. Measurement of the direct <mi>CP> -violating parameter <mi>Ami><mi>CP> in the decay <mi>D>+<mi>Kmi>-<mimi>+<mi>π>+

    SciTech Connect

    Abazov, V. M.; Abbott, B.; Acharya, B. S.; Adams, M.; Adams, T.; Agnew, J. P.; Alexeev, G. D.; Alkhazov, G.; Alton, A.; Askew, A.; Atkins, S.; Augsten, K.; Avila, C.; Badaud, F.; Bagby, L.; Baldin, B.; Bandurin, D. V.; Banerjee, S.; Barberis, E.; Baringer, P.; Bartlett, J. F.; Bassler, U.; Bazterra, V.; Bean, A.; Begalli, M.; Bellantoni, L.; Beri, S. B.; Bernardi, G.; Bernhard, R.; Bertram, I.; Besançon, M.; Beuselinck, R.; Bhat, P. C.; Bhatia, S.; Bhatnagar, V.; Blazey, G.; Blessing, S.; Bloom, K.; Boehnlein, A.; Boline, D.; Boos, E. E.; Borissov, G.; Borysova, M.; Brandt, A.; Brandt, O.; Brock, R.; Bross, A.; Brown, D.; Bu, X. B.; Buehler, M.; Buescher, V.; Bunichev, V.; Burdin, S.; Buszello, C. P.; Camacho-Pérez, E.; Casey, B. C. K.; Castilla-Valdez, H.; Caughron, S.; Chakrabarti, S.; Chan, K. M.; Chandra, A.; Chapon, E.; Chen, G.; Cho, S. W.; Choi, S.; Choudhary, B.; Cihangir, S.; Claes, D.; Clutter, J.; Cooke, M.; Cooper, W. E.; Corcoran, M.; Couderc, F.; Cousinou, M. -C.; Cutts, D.; Das, A.; Davies, G.; de Jong, S. J.; De La Cruz-Burelo, E.; Déliot, F.; Demina, R.; Denisov, D.; Denisov, S. P.; Desai, S.; Deterre, C.; DeVaughan, K.; Diehl, H. T.; Diesburg, M.; Ding, P. F.; Dominguez, A.; Dubey, A.; Dudko, L. V.; Duperrin, A.; Dutt, S.; Eads, M.; Edmunds, D.; Ellison, J.; Elvira, V. D.; Enari, Y.; Evans, H.; Evdokimov, V. N.; Fauré, A.; Feng, L.; Ferbel, T.; Fiedler, F.; Filthaut, F.; Fisher, W.; Fisk, H. E.; Fortner, M.; Fox, H.; Fuess, S.; Garbincius, P. H.; Garcia-Bellido, A.; García-González, J. A.; Gavrilov, V.; Geng, W.; Gerber, C. E.; Gershtein, Y.; Ginther, G.; Gogota, O.; Golovanov, G.; Grannis, P. D.; Greder, S.; Greenlee, H.; Grenier, G.; Gris, Ph.; Grivaz, J. -F.; Grohsjean, A.; Grünendahl, S.; Grünewald, M. W.; Guillemin, T.; Gutierrez, G.; Gutierrez, P.; Haley, J.; Han, L.; Harder, K.; Harel, A.; Hauptman, J. M.; Hays, J.; Head, T.; Hebbeker, T.; Hedin, D.; Hegab, H.; Heinson, A. P.; Heintz, U.; Hensel, C.; Heredia-De La Cruz, I.; Herner, K.; Hesketh, G.; Hildreth, M. D.; Hirosky, R.; Hoang, T.; Hobbs, J. D.; Hoeneisen, B.; Hogan, J.; Hohlfeld, M.; Holzbauer, J. L.; Howley, I.; Hubacek, Z.; Hynek, V.; Iashvili, I.; Ilchenko, Y.; Illingworth, R.; Ito, A. S.; Jabeen, S.; Jaffré, M.; Jayasinghe, A.; Jeong, M. S.; Jesik, R.; Jiang, P.; Johns, K.; Johnson, E.; Johnson, M.; Jonckheere, A.; Jonsson, P.; Joshi, J.; Jung, A. W.; Juste, A.; Kajfasz, E.; Karmanov, D.; Katsanos, I.; Kaur, M.; Kehoe, R.; Kermiche, S.; Khalatyan, N.; Khanov, A.; Kharchilava, A.; Kharzheev, Y. N.; Kiselevich, I.; Kohli, J. M.; Kozelov, A. V.; Kraus, J.; Kumar, A.; Kupco, A.; Kurča, T.; Kuzmin, V. A.; Lammers, S.; Lebrun, P.; Lee, H. S.; Lee, S. W.; Lee, W. M.; Lei, X.; Lellouch, J.; Li, D.; Li, H.; Li, L.; Li, Q. Z.; Lim, J. K.; Lincoln, D.; Linnemann, J.; Lipaev, V. V.; Lipton, R.; Liu, H.; Liu, Y.; Lobodenko, A.; Lokajicek, M.; Lopes de Sa, R.; Luna-Garcia, R.; Lyon, A. L.; Maciel, A. K. A.; Madar, R.; Magaña-Villalba, R.; Malik, S.; Malyshev, V. L.; Mansour, J.; Martínez-Ortega, J.; McCarthy, R.; McGivern, C. L.; Meijer, M. M.; Melnitchouk, A.; Menezes, D.; Mercadante, P. G.; Merkin, M.; Meyer, A.; Meyer, J.; Miconi, F.; Mondal, N. K.; Mulhearn, M.; Nagy, E.; Narain, M.; Nayyar, R.; Neal, H. A.; Negret, J. P.; Neustroev, P.; Nguyen, H. T.; Nunnemann, T.; Orduna, J.; Osman, N.; Osta, J.; Pal, A.; Parashar, N.; Parihar, V.; Park, S. K.; Partridge, R.; Parua, N.; Patwa, A.; Penning, B.; Perfilov, M.; Peters, Y.; Petridis, K.; Petrillo, G.; Pétroff, P.; Pleier, M. -A.; Podstavkov, V. M.; Popov, A. V.; Prewitt, M.; Price, D.; Prokopenko, N.; Qian, J.; Quadt, A.; Quinn, B.; Ratoff, P. N.; Razumov, I.; Ripp-Baudot, I.; Rizatdinova, F.; Rominsky, M.; Ross, A.; Royon, C.; Rubinov, P.; Ruchti, R.; Sajot, G.; Sánchez-Hernández, A.; Sanders, M. P.; Santos, A. S.; Savage, G.; Savitskyi, M.; Sawyer, L.; Scanlon, T.; Schamberger, R. D.; Scheglov, Y.; Schellman, H.; Schwanenberger, C.; Schwienhorst, R.; Sekaric, J.; Severini, H.; Shabalina, E.; Shary, V.; Shaw, S.; Shchukin, A. A.; Simak, V.; Skubic, P.; Slattery, P.; Smirnov, D.; Snow, G. R.; Snow, J.; Snyder, S.; Söldner-Rembold, S.; Sonnenschein, L.; Soustruznik, K.; Stark, J.; Stoyanova, D. A.; Strauss, M.; Suter, L.; Svoisky, P.; Titov, M.; Tokmenin, V. V.; Tsai, Y. -T.; Tsybychev, D.; Tuchming, B.; Tully, C.; Uvarov, L.; Uvarov, S.; Uzunyan, S.; Van Kooten, R.; van Leeuwen, W. M.; Varelas, N.; Varnes, E. W.; Vasilyev, I. A.; Verkheev, A. Y.; Vertogradov, L. S.; Verzocchi, M.; Vesterinen, M.; Vilanova, D.; Vokac, P.; Wahl, H. D.; Wang, M. H. L. S.; Warchol, J.; Watts, G.; Wayne, M.; Weichert, J.; Welty-Rieger, L.; Williams, M. R. J.; Wilson, G. W.; Wobisch, M.; Wood, D. R.; Wyatt, T. R.; Xie, Y.; Yamada, R.; Yang, S.; Yasuda, T.; Yatsunenko, Y. A.; Ye, W.; Ye, Z.; Yin, H.; Yip, K.; Youn, S. W.; Yu, J. M.; Zennamo, J.; Zhao, T. G.; Zhou, B.; Zhu, J.; Zielinski, M.; Zieminska, D.; Zivkovic, L.

    2014-12-01

    We measure the direct mi>Cmi>mi>P>-violating parameter mi>Ami>mi>Cmi>mi>Pmi> for the decay of the charged charm meson, mi>Dmi>+mi>Kmi>-mi>πmi>+mi>πmi>+ (and charge conjugate), using the full 10.4 mi>fbmi>-1 sample of mi>p>mi>p>¯ collisions at mi>smi>=1.96 mi>TeVmi> collected by the D0 detector at the Fermilab Tevatron collider. We extract the raw reconstructed charge asymmetry by fitting the invariant mass distributions for the sum and difference of charge-specific samples. This quantity is then corrected for detector-related asymmetries using data-driven methods and for possible physics asymmetries (from mi>B>mi>D

  1. DOE Zero Energy Ready Home Case Study: AquaZephyr, Ithaca, NY...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    AquaZephyr, Ithaca, NY DOE Zero Energy Ready Home Case Study: AquaZephyr, Ithaca, NY Case study of a DOE Zero Energy Ready home in Ithaca, NY, that achieves a HERS 56 without PV or ...

  2. DOE - Office of Legacy Management -- Ithaca Gun Co Inc - NY 53

    Office of Legacy Management (LM)

    Ithaca Gun Co Inc - NY 53 FUSRAP Considered Sites Site: ITHACA GUN CO., INC. (NY.53 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate ...

  3. DOE - Office of Legacy Management -- Gleason Works - NY 55

    Office of Legacy Management (LM)

    on October 30 Thru November 10, 1961; December 13, 1961 NY.55-2 - DOE Memorandum; Williams to File; Elimination of the Sites from the Formerly Utilized Sites Remedial Action...

  4. DOE - Office of Legacy Management -- Colonie - NY 06

    Office of Legacy Management (LM)

    of Engineers but will eventually transfer to the U.S. Department of Energy Office of Legacy Management. NY.06-1 - DOE Report (DOEOR20722-53); Colonie Interim Storage Site...

  5. DOE - Office of Legacy Management -- Colonie - NY 06

    Office of Legacy Management (LM)

    transfer to the U.S. Department of Energy Office of Legacy Management. NY.06-1 - DOE Report (DOEOR20722-53); Colonie Interim Storage Site Environmental Monitoring Report, ...

  6. Buffalo, NY Liquefied Natural Gas Exports to Canada (Million...

    Energy Information Administration (EIA) (indexed site)

    to Canada (Million Cubic Feet) Buffalo, NY Liquefied Natural Gas Exports to Canada (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2015 1 1 1 1 - No ...

  7. RenewableNY - An Industrial Energy Conservation Initiative

    SciTech Connect

    Lubarr, Tzipora

    2009-09-30

    The New York Industrial Retention Network (NYIRN) manages the RenewableNY program to assist industrial companies in New York City to implement energy efficiency projects. RenewableNY provides companies with project management assistance and grants to identify opportunities for energy savings and implement energy efficiency projects. The program helps companies identify energy efficient projects, complete an energy audit, and connect with energy contractors who install renewable energy and energy efficient equipment. It also provides grants to help cover the costs of installation for new systems and equipment. RenewableNY demonstrates that a small grant program that also provides project management assistance can incentivize companies to implement energy efficiency projects that might otherwise be avoided. Estimated savings through RenewableNY include 324,500 kWh saved through efficiency installations, 158 kW of solar energy systems installed, and 945 thm of gas avoided.

  8. DOE - Office of Legacy Management -- National Carbon Co - NY...

    Office of Legacy Management (LM)

    NY.48-1 - AEC Letter; Crenshaw to National Carbon Company (Attn.: Nolan); Purchase Order Request for 358 Tons of Graphite by E. I. DuPont de Nemours & Company; February 2, 1943 ...

  9. NY-Sun Commerical/Industrial Incentive Program

    Office of Energy Efficiency and Renewable Energy (EERE)

    New York State Energy Research and Development Authority (NYSERDA) through NY-Sun Commercial/Industrial Incentive Program (PON 3082) provides incentives for installation of non-residential new grid...

  10. DOE - Office of Legacy Management -- Ledoux and Co - NY 37

    Office of Legacy Management (LM)

    Recommendation; August 7, 1987 NY.37-2 - DOE Letter; James W. Wagoner II to Rudolph Giuliani; Subject: Elimination of LeDoux and Co. site in New York City; December 12, 1994...

  11. New York State Energy Research and Development Authority, Albany, NY |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy York State Energy Research and Development Authority, Albany, NY New York State Energy Research and Development Authority, Albany, NY This presentation on the NYSERDA Hydrogen Program was given on July 12, 2006. education_presentation_nyserda.pdf (2.64 MB) More Documents & Publications NYSERDA's RPS Customer Sited Tier Fuel Cell Program State of the States: Fuel Cells in America 2014 State of the States: Fuel Cells in America 2010

  12. Fate of hazardous waste derived organic compounds in Lake Ontario

    SciTech Connect

    Jaffe, R.; Hites, R.A.

    1986-03-01

    Dated sediment cores from Lake Ontario's four sedimentation basins and sedentary fish from tributaries and embayments were analyzed by gas chromatographic, methane-enhanced, negative ion mass spectrometry for a group of fluorinated aromatic compounds. The historical record of these chemicals in Lake Ontario sediments agrees well with the use of the Hyde Park dump in the city of Niagara Falls, NY. These compounds first appeared in sediments in 1958 and rapidly increased until 1970. These dates coincide with the onset of dumping at Hyde Park and remedial action undertaken when this dump was closed, respectively. Chemicals introduced into Lake Ontario by the Niagara River distribute throughout the lake rapidly and uniformly and accumulate in sedentary fish taken from remote locations in the lake. 24 references, 9 figures, 4 tables.

  13. Champlain, NY Natural Gas Liquefied Natural Gas Imports (Million Cubic

    Energy Information Administration (EIA) (indexed site)

    Feet) (Million Cubic Feet) Champlain, NY Natural Gas Liquefied Natural Gas Imports (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2014 63 2015 1 2 1 2 20 2016 56 76 20 20 3 4 3 4 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Liquefied Natural Gas Imports by Point of Entry Champlain, NY LNG Imports from All

  14. Submit Your Ideas for the NY Energy Data Jam | Department of...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Submit Your Ideas for the NY Energy Data Jam Submit Your Ideas for the NY Energy Data Jam June 19, 2013 - 11:03am Q&A What idea would you present at the Data Jam? Join the...

  15. DOE - Office of Legacy Management -- Pyroferric Co - NY 0-20

    Office of Legacy Management (LM)

    Designated Name: Not Designated Alternate Name: None Location: 621 E. 216th Street , New York , New York NY.0-20-1 Evaluation Year: 1987 NY.0-20-1 Site Operations: One small...

  16. DOE - Office of Legacy Management -- Lucius Pitkin - NY 0-15

    Office of Legacy Management (LM)

    Contractor supervised activities at Middlesex Sampling Plant in Middlesex, NJ such as assaying, sampling and weighing of ore. NY.0-15-1 NY.0-15-2 Site Disposition: Eliminated - No ...

  17. Interoperability of Demand Response Resources Demonstration in NY

    SciTech Connect

    Wellington, Andre

    2014-03-31

    The Interoperability of Demand Response Resources Demonstration in NY (Interoperability Project) was awarded to Con Edison in 2009. The objective of the project was to develop and demonstrate methodologies to enhance the ability of customer sited Demand Response resources to integrate more effectively with electric delivery companies and regional transmission organizations.

  18. US ENC MI Site Consumption

    Energy Information Administration (EIA) (indexed site)

    MI Site Consumption million Btu $0 $500 $1,000 $1,500 $2,000 $2,500 US ENC MI Expenditures dollars ALL ENERGY average per household (excl. transportation) 0 2,000 4,000 6,000 8,000 10,000 12,000 US ENC MI Site Consumption kilowatthours $0 $250 $500 $750 $1,000 $1,250 $1,500 US ENC MI Expenditures dollars ELECTRICITY ONLY average per household * Michigan households use 123 million Btu of energy per home, 38% more than the U.S. average. * High consumption, combined with low costs for heating fuels

  19. Great Lakes Steel -- PCI facility

    SciTech Connect

    Eichinger, F.T.; Dake, S.H.; Wagner, E.D.; Brown, G.S.

    1997-12-31

    This paper discusses the planning, design, and start-up of the 90 tph PCI facility for National Steel`s Great Lakes Steel Division in River Rouge, MI. This project is owned and operated by Edison Energy Services, and was implemented on a fast-track basis by Raytheon Engineers and Constructors, Babcock Material Handling, and Babcock and Wilcox. This paper presents important process issues, basic design criteria, an the challenges of engineering and building a state-of-the-art PCI facility in two existing plants. Pulverized coal is prepared at the River Rouge Power Plant of Detroit Edison, is pneumatically conveyed 6,000 feet to a storage silo at Great Lakes Steel, and is injected into three blast furnaces.

  20. DOE - Office of Legacy Management -- Wolff-Alport and Co - NY...

    Office of Legacy Management (LM)

    Operations: Commercial operation -- sold thorium residues to the AEC, which in turn ... Primary Radioactive Materials Handled: Thorium NY.30-2 Radiological Survey(s): No Site ...

  1. DOE Zero Energy Ready Home Case Study: Greenhill Contracting, New Paltz, NY

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    | Department of Energy New Paltz, NY DOE Zero Energy Ready Home Case Study: Greenhill Contracting, New Paltz, NY DOE Zero Energy Ready Home Case Study: Greenhill Contracting, New Paltz, NY Case study of a DOE Zero Energy Ready home in New Paltz, NY, that achieved a HERS score of 37 without PV or 7 with 7.5-kW PV. The two-story 2,288-ft2 home is one of 9 certified homes. All of the homes have R-22 ICF walls, R-20 closed-cell spray foam under the slab, a ground-source heat pump with

  2. US ENC MI Site Consumption

    Annual Energy Outlook

    ... Yes Yes No No 0% 20% 40% 60% 80% 100% US MI No Car CAR IS PARKED WITHIN 20 FT OF ELECTRICAL OUTLET More highlights from RECS on housing characteristics and energy-related ...

  3. Microsoft PowerPoint - Xie_twpice_NY06.ppt

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Variational Analysis of Tropical Warm Pool International Cloud Experiment (TWP_ICE) Data (01/22/2006 - 2/13/2006) The TWP_ICE Workshop , NASA/GISS, New York, NY, 13-15 November, 2006 A joint effort between LLNL (Xie, McCoy, Klein), BMRC (Hume, Jakob), SUNYSB (Zhang), and other TWPICE participants 143km 130km 172km 99km 148km A Quick Update Done! 3-hourly radiosondes (6 stations) Background field from the ECMWF analysis Radar precipitation Surface turbulence fluxes from Monash University (Darwin

  4. Champlain, NY Natural Gas Liquefied Natural Gas Imports from Canada

    Energy Information Administration (EIA) (indexed site)

    (Million Cubic Feet) from Canada (Million Cubic Feet) Champlain, NY Natural Gas Liquefied Natural Gas Imports from Canada (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2014 63 2015 1 2 1 2 20 2016 56 76 20 20 3 4 3 4 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Liquefied Natural Gas Imports by Point of Entry

  5. FIRST Robotics at NY Tech Valley | GE Global Research

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Pit Boss Reflects on Bot Challenge Click to email this to a friend (Opens in new window) Share on Facebook (Opens in new window) Click to share (Opens in new window) Click to share on LinkedIn (Opens in new window) Click to share on Tumblr (Opens in new window) Pit Boss Reflects on Bot Challenge Lynn DeRose 2015.03.27 Hi everyone, from BBQ to robots all in the same week! This past weekend I had the privilege to volunteer at the FIRST(tm) Robotics Competition (FRC) NY Tech Valley Regional at RPI.

  6. Real-time sub-<mi>>ngstrom...

    Office of Scientific and Technical Information (OSTI)

    Real-time sub-<mi>>ngstrom imaging of reversible and irreversible conformations in rhodium catalysts and graphene Kisielowski, Christian; Wang,...

  7. Champlain, NY Natural Gas Pipeline Imports From Canada (Dollars per

    Energy Information Administration (EIA) (indexed site)

    Thousand Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 3.29 3.40 3.53 3.68 2000's 3.86 4.03 4.17 4.34 4.53 4.81 5.04 5.23 5.63 5.21 2010's 6.02 6.11 4.50 7.22 13.60 5.57 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Price of Natural Gas Pipeline Imports by Point of Entry Champlain, NY

  8. Mi GmbH | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Mi GmbH Jump to: navigation, search Name: Mi GmbH Place: Switzerland Zip: CH-6340 Sector: Solar Product: Baar-based manufacturer and distributor of fruit juices. The firm is also...

  9. Red Lake Weatherization Project

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    REVIEW RED LAKE WEATHERIZATION PROJECT BERT VAN WERT ENERGY ACTIVITIES COORDINATOR Project Overview To develop the capacity to conduct energy audits Implement energy efficiency measures into Tribal homes Develop a Tribally administered Energy Efficiency Program and business PROJECT LOCATION Our project is located at Red Lake Housing Authority Red Lake Band of Chippewa Indians Red Lake , MN Red Lake Band of Chippewas Area overview Reservation (Diminished Lands) and Surroundings Red Lake Band of

  10. miRNAs in brain development

    SciTech Connect

    Petri, Rebecca; Malmevik, Josephine; Fasching, Liana; Åkerblom, Malin; Jakobsson, Johan

    2014-02-01

    MicroRNAs (miRNAs) are small, non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. In the brain, a large number of miRNAs are expressed and there is a growing body of evidence demonstrating that miRNAs are essential for brain development and neuronal function. Conditional knockout studies of the core components in the miRNA biogenesis pathway, such as Dicer and DGCR8, have demonstrated a crucial role for miRNAs during the development of the central nervous system. Furthermore, mice deleted for specific miRNAs and miRNA-clusters demonstrate diverse functional roles for different miRNAs during the development of different brain structures. miRNAs have been proposed to regulate cellular functions such as differentiation, proliferation and fate-determination of neural progenitors. In this review we summarise the findings from recent studies that highlight the importance of miRNAs in brain development with a focus on the mouse model. We also discuss the technical limitations of current miRNA studies that still limit our understanding of this family of non-coding RNAs and propose the use of novel and refined technologies that are needed in order to fully determine the impact of specific miRNAs in brain development. - Highlights: • miRNAs are essential for brain development and neuronal function. • KO of Dicer is embryonically lethal. • Conditional Dicer KO results in defective proliferation or increased apoptosis. • KO of individual miRNAs or miRNA families is necessary to determine function.

  11. File:USDA-CE-Production-GIFmaps-NY.pdf | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    NY.pdf Jump to: navigation, search File File history File usage New York Ethanol Plant Locations Size of this preview: 776 600 pixels. Full resolution (1,650 1,275 pixels,...

  12. Price of Champlain, NY Natural Gas LNG Imports (Dollars per Thousand...

    Annual Energy Outlook

    (Dollars per Thousand Cubic Feet) Price of Champlain, NY Natural Gas LNG Imports (Dollars per Thousand Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2014 10.69 -...

  13. Price of Champlain, NY Natural Gas LNG Imports from Canada (Dollars...

    Gasoline and Diesel Fuel Update

    from Canada (Dollars per Thousand Cubic Feet) Price of Champlain, NY Natural Gas LNG Imports from Canada (Dollars per Thousand Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep...

  14. BuildSmart NY Innovators Summit Offers Sneak Peek at Better Buildings

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Challenge Solutions to Come | Department of Energy BuildSmart NY Innovators Summit Offers Sneak Peek at Better Buildings Challenge Solutions to Come BuildSmart NY Innovators Summit Offers Sneak Peek at Better Buildings Challenge Solutions to Come September 18, 2014 - 12:32pm Addthis The graphic above highlights New York Power Authority’s energy efficiency goals. | Courtesy of New York Power Authority The graphic above highlights New York Power Authority's energy efficiency goals. |

  15. Lakes_Elec_You

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Lakes, Electricity & You Why It's So Important That Lakes Are Used To Generate Electricity Why We Can Thank Our Lakes For Electricity Because lakes were made to generate electricity. Back in the mid-1940s, Congress recognized the need for better flood control and navigation. To pay for these services, Congress passed laws that started the building of federal hydroelectric dams, and sold the power from the dams under long-term contracts. Today these dams provide efficient, environmentally

  16. DOE - Office of Legacy Management -- Detrex Corp - MI 10

    Office of Legacy Management (LM)

    Detroit , Michigan MI.10-1 Evaluation Year: 1987 MI.10-2 Site Operations: Conducted experimental runs relative to picklingdegreasing of one handful of uranium turnings MI.10-1...

  17. DOE - Office of Legacy Management -- Adrian - MI 01

    Office of Legacy Management (LM)

    Adrian - MI 01 FUSRAP Considered Sites Adrian, MI Alternate Name(s): Bridgeport Brass Co. Special Metals Extrusion Plant Bridgeport Brass Company General Motors General Motors Company, Adrian MI.01-1 Location: 1450 East Beecher Street, Adrian, Michigan MI.01-3 Historical Operations: Performed uranium extrusion research and development and metal fabrication work for the AEC using uranium, thorium, and plutonium. MI.01-2 Eligibility Determination: Eligible MI.01-1 Radiological Survey(s):

  18. ,"Champlain, NY Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Champlain, NY Natural Gas Pipeline Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Champlain, NY Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  19. Price of Buffalo, NY Liquefied Natural Gas Exports to Canada (Dollars per

    Energy Information Administration (EIA) (indexed site)

    Thousand Cubic Feet) Buffalo, NY Liquefied Natural Gas Exports to Canada (Dollars per Thousand Cubic Feet) Price of Buffalo, NY Liquefied Natural Gas Exports to Canada (Dollars per Thousand Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 2000's -- 12.07 -- -- 2010's -- -- 7.68 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date:

  20. Submit Your Ideas for the NY Energy Data Jam | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Ideas for the NY Energy Data Jam Submit Your Ideas for the NY Energy Data Jam June 19, 2013 - 11:03am Q&A What idea would you present at the Data Jam? Join the Conversation Addthis Applications powered by open energy data were on display at the Energy Datapalooza in June 2012. | Photo by Sarah Gerrity, Energy Department. Applications powered by open energy data were on display at the Energy Datapalooza in June 2012. | Photo by Sarah Gerrity, Energy Department. Alex Cohen Alex Cohen Former

  1. DOE - Office of Legacy Management -- Oliver Corp - MI 11

    Office of Legacy Management (LM)

    OLIVER CORP. (MI.11 ) Eliminated from further consideration under FUSRAP - Referred to NRC Designated Name: Not Designated Alternate Name: Behnke Warehousing Incorporated MI.11-1...

  2. U.S. Total Imports

    Energy Information Administration (EIA) (indexed site)

    St. Clair, MI International Falls, MN Noyes, MN Warroad, MN Babb, MT Havre, MT Port of Del Bonita, MT Port of Morgan, MT Sweetgrass, MT Whitlash, MT Portal, ND Sherwood, ND Pittsburg, NH Champlain, NY Grand Island, NY Massena, NY Niagara Falls, NY Waddington, NY Sumas, WA Highgate Springs, VT North Troy, VT U.S. Pipeline Total from Mexico Ogilby, CA Otay Mesa, CA Alamo, TX El Paso, TX Galvan Ranch, TX Hidalgo, TX McAllen, TX Penitas, TX LNG Imports from Algeria Cove Point, MD Everett, MA Lake

  3. DOE Zero Energy Ready Home Case Study: Greenhill Contracting, New Paltz, NY

    Energy.gov [DOE]

    Case study of a DOE Zero Energy Ready home in New Paltz, NY, that achieved a HERS score of 37 without PV or 7 with 7.5-kW PV. The two-story 2,288-ft2 home is one of 9 certified homes. All of the...

  4. DOE Zero Energy Ready Home Case Study: AquaZephyr, Ithaca, NY

    Energy.gov [DOE]

    Case study of a DOE Zero Energy Ready home in Ithaca, NY, that achieves a HERS 56 without PV or HERS 15 with 4-kW of PV. The two-story, 1,664-ft2 home is one of 17 single-family and 4 duplex homes...

  5. SGDP Report Now Available: Interoperability of Demand Response Resources Demonstration in NY (February 2015)

    Energy.gov [DOE]

    The Interoperability of Demand Response Resources Demonstration in NY was awarded to Con Edison in 2009 as part of DOE's Smart Grid Demonstration Project (SGDP) grants funded by the Recovery Act. The objective of the project was to develop and demonstrate methodologies to enhance the ability of customer sited demand response resources, both conventional and renewable, to integrate more effectively with electric delivery companies

  6. DOE Zero Energy Ready Home Case Study: AquaZephyr, Ithaca, NY...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Case study of a DOE Zero Energy Ready home in Ithaca, NY, that achieves a HERS 56 without PV or HERS 15 with 4-kW of PV. The two-story, 1,664-ft2 home is one of 17 single-family ...

  7. The NuMI neutrino beam

    DOE PAGES [OSTI]

    Adamson, P.; Anderson, K.; Andrews, M.; Andrews, R.; Anghel, I.; Augustine, D.; Aurisano, A.; Avvakumov, S.; Ayres, D. S.; Baller, B.; et al

    2015-10-20

    Our paper describes the hardware and operations of the Neutrinos at the Main Injector (NuMI) beam at Fermilab. It elaborates on the design considerations for the beam as a whole and for individual elements. The most important part of our design details pertaining to individual components is described. Beam monitoring systems and procedures, including the tuning and alignment of the beam and NuMI long-term performance, are also discussed.

  8. The NuMI Neutrino Beam

    SciTech Connect

    Adamson, P.; Anderson, K.; Andrews, M.; Andrews, R.; Anghel, I.; Augustine, D.; Aurisano, A.; Avvakumov, S.; Ayres, D. S.; Baller, B.; Barish, B.; Barr, G.; Barrett, W. L.; Berstein, R. H.; Biggs, J.; Bishai, M.; Blake, A.; Bocean, V.; Bock, G. J.; Boehnlein, D. J.; Bogert, D.; Bourkland, K.; Cao, S. V.; Castromonte, C. M.; Childress, S.; Choudhary, B. C.; Coelho, J. A.B.; Cobb, J. H.; Corwin, L.; Crane, D.; Cravens, J. P.; Cronin-Hennessy, D.; Ducar, R. J.; De Jong, J. K.; Devan, A. V.; Devenish, N. E.; Diwan, M. V.; Erwin, A. R.; Escobar, C. O.; Evans, J. J.; Falk, E.; Feldman, G. J.; Fields, T. H.; Ford, R.; Frohne, M. V.; Gallahger, H. R.; Garkusha, V.; Gomes, R. A.; Goodman, M. C.; Gouffon, P.; Graf, N.; Gran, R.; Grossman, N.; Grzelak, K.; Habig, A.; Hahn, S. R.; Harding, D.; Harris, D.; Harris, P. G.; Hartnell, J.; Hatcher, R.; Hays, S.; Heller, K.; Holin, A.; Huang, J.; Hylen, J.; Ibrahim, A.; Indurthy, D.; Irwin, G. M.; Isvan, Z.; Jaffe, D. E.; James, C.; Jensen, D.; Johnstone, J.; Kafka, T.; Kasahara, S. M.S.; Koizumi, G.; Kopp, S.; Kordosky, M.; Kreymer, A.; Lang, K.; Laughton, C.; Lefeuvre, G.; Ling, J.; Litchfield, P. J.; Loiacono, L.; Lucas, P.; Mann, W. A.; Marchionni, A.; Marshak, M. L.; Mayer, N.; McGivern, C.; Medeiros, M. M.; Mehdiyev, R.; Meier, J. R.; Messier, M. D.; Michael, D. G.; Milburn, R. H.; Miller, J. L.; Miller, W. H.; Mishra, S. R.; Sher, S. Moed; Moore, C. D.; Morfin, J.; Mualem, L.; Mufson, S.; Murgia, S.; Murtagh, M.; Musser, J.; Naples, D.; Nelson, J. K.; Newman, H. B.; Nichol, R. J.; Nowak, J. A.; O'connor, J.; Oliver, W. P.; Olsen, M.; Orchanian, M.; Osprey, S.; Pahlka, R. B.; Paley, J.; Para, A.; Patterson, R. B.; Patzak, T.; Pavlovic, Z.; Pawloski, G.; Perch, A.; Peterson, E. A.; Petyt, D. A.; Pfutzner, M. M.; Phan-Budd, S.; Plunkett, R. K.; Poonthottathil, N.; Prieto, P.; Pushka, D.; Qiu, X.; Radovic, A.; Rameika, R. A.; Ratchford, J.; Rebel, B.; Reilly, R.; Rosenfeld, C.; Rubin, H. A.; Ruddick, K.; Sanchez, M. C.; Saoulidou, N.; Sauer, L.; Schneps, J.; Schoo, D.; Schreckenberger, A.; Schreiner, P.; Shanahan, P.; Sharma, R.; Smart, W.; Smith, C.; Sousa, A.; Stefanik, A.; Tagg, N.; Talaga, R. L.; Tassotto, G.; Thomas, J.; Thompson, J.; Thomson, M. A.; Tian, X.; Timmons, A.; Tinsley, D.; Tognini, S. C.; Toner, R.; Torretta, D.; Trostin, I.; Tzanakos, G.; Urheim, J.; Vahle, P.; Vaziri, K.; Villegas, E.; Viren, B.; Vogel, G.; Webber, R. C.; Weber, A.; Webb, R. C.; Wehmann, A.; White, C.; Whitehead, L.; Whitehead, L. H.; Wojcicki, S. G.; Wong-Squires, M. L.; Yang, T.; Yumiceva, F. X.; Zarucheisky, V.; Zwaska, R.

    2015-10-20

    Our paper describes the hardware and operations of the Neutrinos at the Main Injector (NuMI) beam at Fermilab. It elaborates on the design considerations for the beam as a whole and for individual elements. The most important part of our design details pertaining to individual components is described. Beam monitoring systems and procedures, including the tuning and alignment of the beam and NuMI long-term performance, are also discussed.

  9. DOE Zero Energy Ready Home Case Study: Ferguson Design and Construction Inc., Sagaponack, NY, Custom Home

    Energy.gov [DOE]

    Case study of a DOE Zero Energy Ready Home in Long Island, NY, that scored HERS 43 without PV. This 5,088-square-foot custom home has R-25 double-stud walls, a vaulted roof with R-40 blown cellulose, R-10 XPS under slab, a hydro air system with 91% efficient boiler for forced air and radiant floor heat, and 100% LED lights.

  10. DOE Zero Energy Ready Home Case Study 2013: Ithaca Neighborhood Housing Services, Ithaca, NY

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Ithaca Neighborhood Housing Services Ithaca, NY BUILDING TECHNOLOGIES OFFICE The U.S. Department of Energy invites home builders across the country to meet the extraordinary levels of excellence and quality specifi ed in DOE's Zero Energy Ready Home program (formerly known as Challenge Home). Every DOE Zero Energy Ready Home starts with ENERGY STAR for Homes Version 3 for an energy-effi cient home built on a solid foundation of building science research. Advanced technologies are designed in to

  11. Port Huron, MI Liquefied Natural Gas Exports to Canada (Million...

    Energy Information Administration (EIA) (indexed site)

    Huron, MI Liquefied Natural Gas Exports to Canada (Million Cubic Feet) Port Huron, MI Liquefied Natural Gas Exports to Canada (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul ...

  12. DOE - Office of Legacy Management -- Naval Ordnance Plant - MI...

    Office of Legacy Management (LM)

    Eliminated from further consideration under FUSRAP - Referred to DoD for action Designated ... MI.0-03-1 Site Disposition: Eliminated - No Authority - Referred to DoD MI.0-03-1 ...

  13. miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor

    SciTech Connect

    Park, Jong-Kook; Henry, Jon C.; Jiang, Jinmai; Esau, Christine; Gusev, Yuriy; Lerner, Megan R.; Postier, Russell G.; Brackett, Daniel J.; Schmittgen, Thomas D.

    2011-03-25

    Research highlights: {yields} The expression of miR-132 and miR-212 are significantly increased in pancreatic cancer. {yields} miR-132 and miR-212 target the tumor suppressor pRb, resulting in enhanced proliferation. {yields} miR-132 and miR-212 expression is increased by a {beta}2 adrenergic receptor agonist, suggesting a novel mechanism for pancreatic cancer progression. -- Abstract: Numerous microRNAs (miRNAs) are reported as differentially expressed in cancer, however the consequence of miRNA deregulation in cancer is unknown for many miRNAs. We report that two miRNAs located on chromosome 17p13, miR-132 and miR-212, are over-expressed in pancreatic adenocarcinoma (PDAC) tissues. Both miRNAs are predicted to target the retinoblastoma tumor suppressor, Rb1. Validation of this interaction was confirmed by luciferase reporter assay and western blot in a pancreatic cancer cell line transfected with pre-miR-212 and pre-miR-132 oligos. Cell proliferation was enhanced in Panc-1 cells transfected with pre-miR-132/-212 oligos. Conversely, antisense oligos to miR-132/-212 reduced cell proliferation and caused a G{sub 2}/M cell cycle arrest. The mRNA of a number of E2F transcriptional targets were increased in cells over expressing miR-132/-212. Exposing Panc-1 cells to the {beta}2 adrenergic receptor agonist, terbutaline, increased the miR-132 and miR-212 expression by 2- to 4-fold. We report that over-expression of miR-132 and miR-212 result in reduced pRb protein in pancreatic cancer cells and that the increase in cell proliferation from over-expression of these miRNAs is likely due to increased expression of several E2F target genes. The {beta}2 adrenergic pathway may play an important role in this novel mechanism.

  14. “Nodal Gap” induced by the incommensurate diagonal spin density modulation in underdoped high- <mi>Tmi>c> superconductors

    SciTech Connect

    Zhou, Tao; Gao, Yi; Zhu, Jian -Xin

    2015-03-07

    Recently it was revealed that the whole Fermi surface is fully gapped for several families of underdoped cuprates. The existence of the finite energy gap along the <mi>d>-wave nodal lines (nodal gap) contrasts the common understanding of the <mi>d>-wave pairing symmetry, which challenges the present theories for the high-<mi>Tmi><mi>c>superconductors. Here we propose that the incommensurate diagonal spin-density-wave order can account for the above experimental observation. The Fermi surface and the local density of states are also studied. Our results are in good agreement with many important experiments in high-<mi>Tmi><mi>c>superconductors.

  15. Characterization of function and regulation of miR-24-1 and miR-31

    SciTech Connect

    Sun Fenyong; Wang Jiayi; Pan Qiuhui; Yu Yongchun; Zhang Yue; Wan Yang; Wang Ju; Li Xiaoyan; Hong An

    2009-03-13

    To date, numerous microRNAs (miRNAs) have been discovered. However, the function of these miRNAs is largely unknown. While our knowledge of miRNA post-transcriptional processing has greatly expanded in recent years, we have a limited understanding of the regulation and transcription of miRNA genes. In this study, we characterized two BMP-2 upregulated miRNAs, miR-24-1 and miR-31, in mesenchymal stem cells and showed their opposing function in controlling cellular proliferation, and adipogenesis. Furthermore, we are the first to identify and characterize mouse intronic miR-23b{approx}27b{approx}24-1 and intergenic miR-31 genes. Moreover, we found that pri-miR-23b, pri-miR-27b, and pri-miR-24-1 are transcribed independently and their expression profiles are unique when cells are treated with BMP-2, even though they are located closely together.

  16. CRANE CO. 757 THIRD AVENUE NEW YORK. N.Y. THOMAS UNGERLAND ASSOCIATE GENERAL COUNSEL

    Office of Legacy Management (LM)

    ? z _ - c 0-e . CRANE CO. 757 THIRD AVENUE NEW YORK. N.Y. THOMAS UNGERLAND ASSOCIATE GENERAL COUNSEL December 14, 1987 James J. Fiore Director Office of Nuclear Energy Department of Energy Washington, D.C. Re: Crane - Indian Orchard Dear M r. Fiore: W e acknowledge receipt of your letter to Paul Hundt, dated September 29, 1987, which requests certain information about Crane's plant site in Indian Orchard, Massachusetts. The plant is not currently operating. Crane was unable to locate any records

  17. Nitrogen effects on crystallization kinetics of amorphous TiOxNy thin films

    SciTech Connect

    Hukari, Kyle; Dannenberg, Rand; Stach, E.A.

    2001-03-30

    The crystallization behavior of amorphous TiOxNy (x>>y) thin films was investigated by in-situ transmission electron microscopy. The Johnson-Mehl-Avrami-Kozolog (JMAK) theory is used to determine the Avrami exponent, activation energy, and the phase velocity pre-exponent. Addition of nitrogen inhibits diffusion, increasing the nucleation temperature, while decreasing the growth activation energy. Kinetic variables extracted from individual crystallites are compared to JMAK analysis of the fraction transformed and a change of 6 percent in the activation energy gives agreement between the methods. From diffraction patterns and index of refraction the crystallized phase was found to be predominantly anatase.

  18. ,"Grand Island, NY Natural Gas Pipeline Exports to Canada (Million Cubic Feet)"

    Energy Information Administration (EIA) (indexed site)

    Exports to Canada (Million Cubic Feet)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Grand Island, NY Natural Gas Pipeline Exports to Canada (Million Cubic Feet)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  19. ,"Grand Island, NY Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Grand Island, NY Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  20. ,"Massena, NY Natural Gas Pipeline Exports to Canada (Million Cubic Feet)"

    Energy Information Administration (EIA) (indexed site)

    Exports to Canada (Million Cubic Feet)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Massena, NY Natural Gas Pipeline Exports to Canada (Million Cubic Feet)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  1. ,"Massena, NY Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Massena, NY Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  2. ,"Waddington, NY Natural Gas Pipeline Exports to Canada (Million Cubic Feet)"

    Energy Information Administration (EIA) (indexed site)

    Exports to Canada (Million Cubic Feet)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Waddington, NY Natural Gas Pipeline Exports to Canada (Million Cubic Feet)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  3. ,"Waddington, NY Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Waddington, NY Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  4. Price of Champlain, NY Natural Gas LNG Imports from Canada (Dollars per

    Energy Information Administration (EIA) (indexed site)

    Thousand Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 2010's -- 10.69 8.78 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Price of Liquefied Natural Gas Imports by Point of Entry Champlain, NY Natural Gas Exports to

  5. ,"Niagara Falls, NY Natural Gas Pipeline Exports to Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Exports to Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Niagara Falls, NY Natural Gas Pipeline Exports to Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  6. ,"Niagara Falls, NY Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Niagara Falls, NY Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  7. DOE - Office of Legacy Management -- Salt_Lake

    Office of Legacy Management (LM)

    Salt_Lake Salt Lake City Sites ut_map Salt Lake City Disposal Site Salt Lake City Processing Site Last Updated: 12/14/2015

  8. Hydrology of modern and late Holocene lakes, Death Valley, California

    SciTech Connect

    Grasso, D.N.

    1996-07-01

    Above-normal precipitation and surface-water runoff, which have been generally related to the cyclic recurrence of the El Nino-Southern Oscillation, have produced modern ephemeral lakes in the closed-basin Death Valley watershed. This study evaluates the regional hydroclimatic relations between precipitation, runoff, and lake transgressions in the Death Valley watershed. Recorded precipitation, runoff, and spring discharge data for the region are used in conjunction with a closed-basin, lake-water-budget equation to assess the relative contributions of water from these sources to modern lakes in Death Valley and to identify the requisite hydroclimatic changes for a late Holocene perennial lake in the valley. As part of the Yucca Mountain Site Characterization Program, an evaluation of the Quaternary regional paleoflood hydrology of the potential nuclear-waste repository site at Yucca Mountain, Nevada, was planned. The objectives of the evaluation were (1) to identify the locations and investigate the hydraulic characteristics of paleofloods and compare these with the locations and characteristics of modern floods, and (2) to evaluate the character and severity of past floods and debris flows to ascertain the potential future hazards to the potential repository during the pre-closure period (US Department of Energy, 1988). This study addresses the first of these objectives, and the second in part, by assessing and comparing the sizes, locations, and recurrence rates of modern, recorded (1962--83) floods and late Holocene paleofloods for the 8,533-mi{sup 2}, closed-basin, Death Valley watershed with its contributing drainage basins in the Yucca Mountain site area.

  9. Magnetocrystalline anisotropy in <mi>UMn>2<mi>Ge>2 and related Mn-based actinide ferromagnets

    SciTech Connect

    Parker, David S.; Ghimire, Nirmal; Singleton, John; Thompson, J. D.; Bauer, Eric D.; Baumbach, Ryan; Mandrus, David; Li, Ling; Singh, David J.

    2015-05-04

    We present magnetization isotherms in pulsed magnetic fields up to 62 Tesla, supported by first principles calculations, demonstrating a huge uniaxial magnetocrystalline anisotropy energy - approximately 20 MJ/m3 - in <mi>UMn>2<mi>Ge>2. This large anisotropy results from the extremely strong spin-orbit coupling affecting the uranium 5 f electrons, which in the calculations exhibit a substantial orbital moment exceeding 2 μB. Finally, we also find from theoretical calculations that a number of isostructural Mn-actinide compounds are expected to have similarly large anisotropy.

  10. DOE - Office of Legacy Management -- Star Cutter Corp - MI 15

    Office of Legacy Management (LM)

    Eliminated - Potential for contamination considered remote based on limited scope and quantity of materials handled MI.15-2 Radioactive Materials Handled: Yes Primary ...

  11. MINOS Experiment and NuMI Beam Home Page

    U.S. Department of Energy (DOE) - all webpages

    NuMI-MINOS Neutrino Logo NuMI Beamline and MINOS Experiment Neutrino Logo The MINOS Experiment and NuMI Beamline Fermilab Logo MINOS Experiment Links ◊ MINOS for the Public ◊ Scientific Results ◊ MINOS at Work ◊ NuMI at Work ◊ MINOS+ Experiment Fermilab Neutrino Links ◊ Neutrino FAQ ◊ MINOS Underground Areas at Fermilab ◊ PPD Intensity Frontier Dept Back to - - - ◊ Fermilab at Work ◊ Fermilab Home the MINOS Far Detector in the Soudan Mine MINOS collaborators assembling the

  12. Massena, NY Natural Gas Pipeline Imports From Canada (Million Cubic Feet)

    Energy Information Administration (EIA) (indexed site)

    Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 13,642 12,927 9,184 7,258 2000's 7,309 6,931 7,662 6,817 7,357 6,989 6,588 6,887 6,588 5,730 2010's 5,595 3,965 3,992 4,147 3,819 3,049 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Natural Gas Pipeline Imports by Point of Entry Massena, NY Natural Gas Imports

  13. Massena, NY Natural Gas Pipeline Imports From Canada (Dollars per Thousand

    Energy Information Administration (EIA) (indexed site)

    Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 2.92 3.04 2.78 2.81 2000's 4.25 4.96 4.08 6.08 7.06 9.34 8.95 7.78 9.69 6.85 2010's 6.48 6.55 5.75 6.04 7.34 5.65 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Price of Natural Gas Pipeline Imports by Point of Entry Massena, NY Natural Gas

  14. Champlain, NY Natural Gas Pipeline Imports From Canada (Million Cubic Feet)

    Energy Information Administration (EIA) (indexed site)

    Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 16,104 16,669 15,258 17,171 2000's 17,436 17,329 16,904 12,579 16,502 17,142 17,721 17,666 17,964 13,986 2010's 9,173 8,293 6,766 7,228 4,922 4,446 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Natural Gas Pipeline Imports by Point of Entry Champlain, NY

  15. Grand Island, NY Natural Gas Pipeline Imports From Canada (Dollars per

    Energy Information Administration (EIA) (indexed site)

    Thousand Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 3.35 3.42 2.80 3.07 2000's 4.24 4.08 3.57 6.26 6.63 9.07 7.61 7.41 8.94 4.85 2010's 5.20 4.68 3.01 3.92 9.80 4.23 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Price of Natural Gas Pipeline Imports by Point of Entry Grand Island, NY

  16. The origin and fate of the sediments composing a migrating dune field, Amagansett, NY

    SciTech Connect

    Maher, T. (Suffolk Community Coll., Selden, NY (United States). Environmental Science Dept.); Kandelin, J. (Suffolk Community Coll., Selden, NY (United States). Dept. of Earth and Space Science); Black, J.A. (Geosciences Inc., Patchogue, NY (United States))

    1993-03-01

    The migrating dune system, located in Amagansett, NY, consists of a series of three parabolic dunes ranging in heights from 10 to 30 meters. The dunes are migrating under the influence of the prevailing winds, in a southeasterly direction. The migration continues until the dunes encounter the countervailing prevailing winds, off the Atlantic Ocean. A series of flow charts have been prepared to indicate the possible sources of sediment for this system. These charts, in conjunction with geomorphic analysis, stratigraphic data and various sediment characteristics indicate that the sediments are transported by coastal currents. Once deposited they form a linear dune system. Eolian transport from this dune then supplies the sediment to the migrating dune system.

  17. Geological History of Lake Lahontan, a Quaternary Lake of Northwestern...

    OpenEI (Open Energy Information) [EERE & EIA]

    a Quaternary Lake of Northwestern Nevada Abstract Abstract unavailable. Author Israel C. Russell Organization U.S. Geological Survey Published U.S. Government Printing...

  18. Method for lake restoration

    DOEpatents

    Dawson, Gaynor W.; Mercer, Basil W.

    1979-01-01

    A process for removing pollutants or minerals from lake, river or ocean sediments or from mine tailings is disclosed. Magnetically attractable collection units containing an ion exchange or sorbent media with an affinity for a chosen target substance are distributed in the sediments or tailings. After a period of time has passed sufficient for the particles to bind up the target substances, a magnet drawn through the sediments or across the tailings retrieves the units along with the target substance.

  19. Great Lakes Energy Institute

    SciTech Connect

    Alexander, J. Iwan

    2012-11-18

    The vision of the Great Lakes Energy Institute is to enable the transition to advanced, sustainable energy generation, storage, distribution and utilization through coordinated research, development, and education. The Institute will place emphasis on translating leading edge research into next generation energy technology. The Institute’s research thrusts focus on coordinated research in decentralized power generation devices (e.g. fuel cells, wind turbines, solar photovoltaic devices), management of electrical power transmission and distribution, energy storage, and energy efficiency.

  20. Lake Charles CCS Project

    SciTech Connect

    Leib, Thomas; Cole, Dan

    2015-06-30

    In late September 2014 development of the Lake Charles Clean Energy (LCCE) Plant was abandoned resulting in termination of Lake Charles Carbon Capture and Sequestration (CCS) Project which was a subset the LCCE Plant. As a result, the project was only funded through Phase 2A (Design) and did not enter Phase 2B (Construction) or Phase 2C (Operations). This report was prepared relying on information prepared and provided by engineering companies which were engaged by Leucadia Energy, LLC to prepare or review Front End Engineering and Design (FEED) for the Lake Charles Clean Energy Project, which includes the Carbon Capture and Sequestration (CCS) Project in Lake Charles, Louisiana. The Lake Charles Carbon Capture and Sequestration (CCS) Project was to be a large-scale industrial CCS project intended to demonstrate advanced technologies that capture and sequester carbon dioxide (CO2) emissions from industrial sources into underground formations. The Scope of work was divided into two discrete sections; 1) Capture and Compression prepared by the Recipient Leucadia Energy, LLC, and 2) Transport and Sequestration prepared by sub-Recipient Denbury Onshore, LLC. Capture and Compression-The Lake Charles CCS Project Final Technical Report describes the systems and equipment that would be necessary to capture CO2 generated in a large industrial gasification process and sequester the CO2 into underground formations. The purpose of each system is defined along with a description of its equipment and operation. Criteria for selection of major equipment are provided and ancillary utilities necessary for safe and reliable operation in compliance with environmental regulations are described. Construction considerations are described including a general arrangement of the CCS process units within the overall gasification project. A cost estimate is provided, delineated by system area with cost breakdown showing equipment, piping and materials

  1. Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells

    SciTech Connect

    Vrba, Lukas; Jensen, Taylor J.; Garbe, James C.; Heimark, Ronald L.; Cress, Anne E.; Dickinson, Sally; Stampfer, Martha R.; Futscher, Bernard W.

    2009-12-23

    BACKGROUND: The microRNA-200 family participates in the maintenance of an epithelial phenotype and loss of its expression can result in epithelial to mesenchymal transition (EMT). Furthermore, the loss of expression of miR-200 family members is linked to an aggressive cancer phenotype. Regulation of the miR-200 family expression in normal and cancer cells is not fully understood. METHODOLOGY/ PRINCIPAL FINDINGS: Epigenetic mechanisms participate in the control of miR-200c and miR-141 expression in both normal and cancer cells. A CpG island near the predicted mir-200c/mir-141 transcription start site shows a striking correlation between miR-200c and miR-141 expression and DNA methylation in both normal and cancer cells, as determined by MassARRAY technology. The CpG island is unmethylated in human miR-200/miR-141 expressing epithelial cells and in miR-200c/miR-141 positive tumor cells. The CpG island is heavily methylated in human miR-200c/miR-141 negative fibroblasts and miR-200c/miR-141 negative tumor cells. Mouse cells show a similar inverse correlation between DNA methylation and miR-200c expression. Enrichment of permissive histone modifications, H3 acetylation and H3K4 trimethylation, is seen in normal miR-200c/miR-141-positive epithelial cells, as determined by chromatin immunoprecipitation coupled to real-time PCR. In contrast, repressive H3K9 dimethylation marks are present in normal miR-200c/miR-141-negative fibroblasts and miR-200c/miR-141 negative cancer cells and the permissive histone modifications are absent. The epigenetic modifier drug, 5-aza-2'-deoxycytidine, reactivates miR-200c/miR-141 expression showing that epigenetic mechanisms play a functional role in their transcriptional control. CONCLUSIONS/ SIGNIFICANCE: We report that DNA methylation plays a role in the normal cell type-specific expression of miR-200c and miR-141 and this role appears evolutionarily conserved, since similar results were obtained in mouse. Aberrant DNA methylation of the

  2. Crow Lake Wind | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Wind Jump to: navigation, search Name Crow Lake Wind Facility Crow Lake Wind Sector Wind energy Facility Type Commercial Scale Wind Facility Status In Service Owner Prairie Winds...

  3. Meadow Lake II | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    II Jump to: navigation, search Name Meadow Lake II Facility Meadow Lake II Sector Wind energy Facility Type Commercial Scale Wind Facility Status In Service Owner Horizon Wind...

  4. Blue Lake Power | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Power Jump to: navigation, search Name: Blue Lake Power Place: Redding, California Zip: 96001 Sector: Renewable Energy Product: Blue Lake Power is a wholey owned subsidiary of...

  5. Lake Region State College | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    College Jump to: navigation, search Name Lake Region State College Facility Lake Region State College Sector Wind energy Facility Type Community Wind Facility Status In Service...

  6. Lake Erie Alternative Power | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Power Jump to: navigation, search Name Lake Erie Alternative Power Facility Lake Erie Alternative Power Sector Wind energy Facility Type Offshore Wind Facility Status Proposed...

  7. Summer Lake Aquaculture Aquaculture Low Temperature Geothermal...

    OpenEI (Open Energy Information) [EERE & EIA]

    Summer Lake Aquaculture Aquaculture Low Temperature Geothermal Facility Jump to: navigation, search Name Summer Lake Aquaculture Aquaculture Low Temperature Geothermal Facility...

  8. Iowa Lakes Electric Cooperative | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Iowa Lakes Electric Cooperative Jump to: navigation, search Name: Iowa Lakes Electric Cooperative Place: Estherville, Iowa Zip: 51334 Sector: Wind energy Product: Iowa-based...

  9. PYRAMID LAKE RENEWEABLE ENERGY PLAN

    SciTech Connect

    HIGH DESERT GEOCULTURE, LLC

    2009-06-06

    The Pyramid Lake Renewable Energy Plan covers these areas: energy potential (primarily focusing on geothermal resource potential, but also more generally addressing wind energy potential); renewable energy market potential; transmission system development; geothermal direct use potential; and business structures to accomplish the development objectives of the Pyramid Lake Paiute Tribe.

  10. miR-92a family and their target genes in tumorigenesis and metastasis

    SciTech Connect

    Li, Molin; Guan, Xingfang; Sun, Yuqiang; Mi, Jun; Shu, Xiaohong; Liu, Fang; Li, Chuangang

    2014-04-15

    The miR-92a family, including miR-25, miR-92a-1, miR-92a-2 and miR-363, arises from three different paralog clusters miR-17-92, miR-106a-363, and miR-106b-25 that are highly conservative in the process of evolution, and it was thought as a group of microRNAs (miRNAs) correlated with endothelial cells. Aberrant expression of miR-92a family was detected in multiple cancers, and the disturbance of miR-92a family was related with tumorigenesis and tumor development. In this review, the progress on the relationship between miR-92a family and their target genes and malignant tumors will be summarized. - Highlights: • Aberrant expression of miR-92a, miR-25 and miR-363 can be observed in many kinds of malignant tumors. • The expression of miR-92a family is regulated by LOH, epigenetic alteration, transcriptional factors such as SP1, MYC, E2F, wild-type p53 etc. • Roles of miR-92a family in tumorigenesis and development: promoting cell proliferation, invasion and metastasis, inhibiting cell apoptosis.

  11. HIA 2015 DOE Zero Energy Ready Home Case Study: United Way of Long Island Housing Development Corporation, Patchogue, NY

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Way of Long Island Housing Development Corporation Patchogue, NY DOE ZERO ENERGY READY HOME(tm) The U.S. Department of Energy invites home builders across the country to meet the extraordinary levels of excellence and quality specified in DOE's Zero Energy Ready Home program (formerly known as Challenge Home). Every DOE Zero Energy Ready Home starts with ENERGY STAR Certified Homes Version 3.0 for an energy-efficient home built on a solid foundation of building science research. Advanced

  12. Tular Lake Field, Kings County, California - a significant onshore development

    SciTech Connect

    Lindblom, R.G.; Waldron, J.M.

    1985-04-01

    The Tulare Lake field is located in Kings County, California, on the west side of the San Joaquin Valley and 10 mi east of the Kettleman Hills (North Dome) field and 30 mi souuheast of the city of Coalinga. The field was discovered by Husky Oil Co. (Marathon) in October 1981 with the completion of the Boswell 22-16, Sec. 16, T22S, R20E from sands in the Burbank formation of Oligocene geologic age. Chevron USA offset the Husky discovery well with the completion of the Salyer 678X, Sec. 8, T22S, R20E, in May 1983. Both Chevron and Husky have continued an orderly development of the field, and to date Chevron has 9 producing wells and Husky 10 producing wells. Production is found in the Burbank formation at a vertical depth below 12,800 ft. The entrapment of hydrocarbons is caused by a low amplitude, seismically subtle, anticlinal fold trending northwest/southeast. Isochore maps of the Burbank formation show that stratigraphy is important in the distribution of the four producing sand intervals. Oil gravities form the sands vary 39/sup 0/ API to 51/sup 0/ API and the GOR ranges from 1050 to over 5500. As of January 1, 1984, the field has a cumulative production of 1.7 million bbl of oil and 3.5 billion ft/sup 3/ of gas.

  13. Port Huron, MI Natural Gas Pipeline Imports From Canada (Million...

    Energy Information Administration (EIA) (indexed site)

    Million Cubic Feet) Port Huron, MI Natural Gas Pipeline Imports From Canada (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2016 262 - No Data Reported; ...

  14. miR-107 and miR-25 simultaneously target LATS2 and regulate proliferation and invasion of gastric adenocarcinoma (GAC) cells

    SciTech Connect

    Zhang, Mingjun; Wang, Xiaolei; Li, Wanhu; Cui, Yongchun

    2015-05-08

    Although a series of oncogenes and tumor suppressors were identified in the pathological development of gastric adenocarcinoma (GAC), the underlying molecule mechanism were still not fully understood. The current study explored the expression profile of miR-107 and miR-25 in GAC patients and their downstream regulative network. qRT-PCR analysis was performed to quantify the expression of these two miRNAs in serum samples from both patients and healthy controls. Dual luciferase assay was conducted to verify their putative bindings with LATS2. MTT assay, cell cycle assay and transwell assay were performed to explore how miR-107 and miR-25 regulate proliferation and invasion of gastric cancer cells. Findings of this study demonstrated that total miR-107 or miR-25 expression might be overexpressed in gastric cancer patients and they can simultaneously and synchronically regulate LATS2 expression, thereby affecting gastric cancer cell growth and invasion. Therefore, the miR-25/miR-107-LATS2 axis might play an important role in proliferation and invasion of the gastric cancer cells. - Highlights: • Total miR-107 and miR-25 expression is significantly increased in GAC patients. • Both miR-107 and miR-25 can promote proliferation and invasion of GAC cells. • Both miR-107 and miR-25 can target LATS2 and regulate its expression. • miR-107 and miR-25 regulate proliferation and invasion of GAC cells though LATS2.

  15. Iowa Lakes Superior Wind Farm | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    search Name Iowa Lakes Superior Wind Farm Facility Iowa Lakes Superior Wind Sector Wind energy Facility Type Commercial Scale Wind Facility Status In Service Owner Iowa Lakes...

  16. Iowa Lakes Lakota Wind Farm | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    search Name Iowa Lakes Lakota Wind Farm Facility Iowa Lakes Lakota Wind Sector Wind energy Facility Type Commercial Scale Wind Facility Status In Service Owner Iowa Lakes...

  17. City of Detroit Lakes, Minnesota (Utility Company) | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    Lakes, Minnesota (Utility Company) Jump to: navigation, search Name: City of Detroit Lakes Place: Minnesota Website: www.ci.detroit-lakes.mn.usmai Facebook: https:...

  18. Spirit Lake II Wind Farm | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Lake School District Energy Purchaser Spirit Lake School District Location Spirit Lake IA Coordinates 43.411412, -95.09914 Show Map Loading map... "minzoom":false,"mappingse...

  19. Fish Lake Valley Geothermal Area | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Fish Lake Valley Geothermal Area (Redirected from Fish Lake Valley Area) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Fish Lake Valley Geothermal Area Contents 1...

  20. Soap Lake Pool & Spa Low Temperature Geothermal Facility | Open...

    OpenEI (Open Energy Information) [EERE & EIA]

    Soap Lake Pool & Spa Low Temperature Geothermal Facility Jump to: navigation, search Name Soap Lake Pool & Spa Low Temperature Geothermal Facility Facility Soap Lake Sector...

  1. Hot Lake RV Park Space Heating Low Temperature Geothermal Facility...

    OpenEI (Open Energy Information) [EERE & EIA]

    Lake RV Park Space Heating Low Temperature Geothermal Facility Jump to: navigation, search Name Hot Lake RV Park Space Heating Low Temperature Geothermal Facility Facility Hot Lake...

  2. NBP RFI: Communications Requirements- Comments of Lake Region...

    Energy Saver

    Lake Region Electric Cooperative- Minnesota NBP RFI: Communications Requirements- Comments of Lake Region Electric Cooperative- Minnesota Comments of Lake Region Electric ...

  3. Spirit Lake Tribe- 1995 Project

    Office of Energy Efficiency and Renewable Energy (EERE)

    A long-range goal of the Spirit Lake Nation is to develop a tribally owned and operated municipal power company. The tribe has been awarded a Western Area Power Administration (WAPA) allocation starting in the year 2001.

  4. miR-17 inhibitor suppressed osteosarcoma tumor growth and metastasis via increasing PTEN expression

    SciTech Connect

    Gao, Yong; Luo, Ling-hui; Li, Shuai; Yang, Cao

    2014-02-07

    Highlights: • miR-17 was increased in OS tissues and cell lines. • Inhibition of miR-17 suppressed OS cell proliferation. • Inhibition of miR-17 suppressed OS cell migration and invasion. • PTEN was a target of miR-17. • miR-17 was negatively correlated with PTEN in OS tissues. - Abstract: MicroRNAs (miRNAs) play essential roles in cancer development and progression. Here, we investigated the role of miR-17 in the progression and metastasis of osteosarcoma (OS). miR-17 was frequently increased in OS tissues and cell lines. Inhibition of miR-17 in OS cell lines substantially suppressed cell proliferation, migration, and invasion. Phosphatase and tensin homolog (PTEN) was identified as a target of miR-17, and ectopic expression of miR-17 inhibited PTEN by direct binding to its 3′-untranslated region (3′-UTR). Expression of miR-17 was negatively correlated with PTEN in OS tissues. Together, these findings indicate that miR-17 acts as an oncogenic miRNA and may contribute to the progression and metastasis of OS, suggesting miR-17 as a potential novel diagnostic and therapeutic target of OS.

  5. Lake Charles Liquefaction Project | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Lake Charles Liquefaction Project Lake Charles Liquefaction Project On July 29, 2016, DOE/FE granted Lake Charles Exports, LLC (LCE) and Lake Charles LNG Export Company, LLC (Lake Charles Export) final authorizations to export LNG up to the equivalent of 2.0 Bcf/d of natural gas to non-free trade agreement (non-FTA) countries in DOE/FE Order No. 3324-A to LCE and in DOE/FE Order No. 3868 for Lake Charles LNG Export. The total authorized LNG export volume to non-FTA countries approved between the

  6. HIA 2015 DOE Zero Energy Ready Home Case Study: Greenhill Contracting, Green Acres #20, #26, #28, New Paltz, NY

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Green Acres #20, #26, #28 New Paltz, NY DOE ZERO ENERGY READY HOME(tm) The U.S. Department of Energy invites home builders across the country to meet the extraordinary levels of excellence and quality specified in DOE's Zero Energy Ready Home program (formerly known as Challenge Home). Every DOE Zero Energy Ready Home starts with ENERGY STAR Certified Homes Version 3.0 for an energy-efficient home built on a solid foundation of building science research. Advanced technologies are designed in to

  7. MiR-218 Mediates tumorigenesis and metastasis: Perspectives and implications

    SciTech Connect

    Lu, Ying-fei; Zhang, Li; Waye, Mary Miu Yee; Fu, Wei-ming; Zhang, Jin-fang

    2015-05-15

    MicroRNAs (miRNAs) are a class of small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. As a highly conserved miRNA across a variety of species, microRNA-218 (miR-218) was found to play pivotal roles in tumorigenesis and progression. A group of evidence has demonstrated that miR-218 acts as a tumor suppressor by targeting many oncogenes related to proliferation, apoptosis and invasion. In this review, we provide a complex overview of miR-218, including its regulatory mechanisms, known functions in cancer and future challenges as a potential therapeutic target in human cancers. - Highlights: • miR-218 is frequently down regulated in multiple cancers. • miR-218 plays pivotal roles in carcinogenesis. • miR-218 mediates proliferation, apoptosis, metastasis, invasion, etc. • miR-218 mediates tumorigenesis and metastasis via multiple pathways.

  8. ORISE Research Team Experiences: Joe Lake

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Joe Lake Joe Lake, a full-time software engineer for Oak Ridge National Laboratory's Computational Science and Engineering Division, is doing his part to help foster the next ...

  9. Land O Lakes Inc | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    O Lakes Inc Jump to: navigation, search Name: Land O'Lakes Inc Place: Saint Paul, Minnesota Zip: 55164-0101 Product: Farmer-owned cooperative, marketer of dairy-based products for...

  10. Lakes, Electricity and You | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Lakes, Electricity and You Lakes, Electricity and You Why It's So Important That Lakes Are Used To Generate Electricity Lakes, Electricity and You (1.31 MB) More Documents & Publications A History of the Southeastern Power Administration (1990 - 2010) An Assessment of Energy Potential at Non-Powered Dams in the United States Before The Subcommittee on Water and Power - House Energy and Natural Resources Committee

  11. NuMI Low Energy Flux Prediction Release

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    NuMI Low Energy Flux Prediction Release Neutrino Flux Predictions for the NuMI Beam hep-ex/1607.00704 Data Ancillary data files for this result are available on arXiv at http://arxiv.org/src/1607.00704/anc Among the available data files are: pdf file describing format of all the available files root file of all the available fluxes python code to read and process MINERvA's flux predictions Text Files of the flux, uncertainties, and covariance matrix, with units of neutrinos/m^2/POT, in 0.5 GeV

  12. miRNA-205 affects infiltration and metastasis of breast cancer

    SciTech Connect

    Wang, Zhouquan; Department of Tumor, SenGong Hospital of Shaanxi, Xian 710300 ; Liao, Hehe; Deng, Zhiping; Yang, Po; Du, Ning; Zhanng, Yunfeng; Ren, Hong

    2013-11-08

    Highlights: We detected expression of miR-205 in breast cancer cell lines and tissue samples. We suggest miR-205 is downregulated in human breast cancer tissues and MCF7 cells. We suggest the lower expression of miR-205 play a role in breast cancer onset. These data suggest that miR-205 directly targets HER3 in human breast cancer. -- Abstract: Background: An increasing number of studies have shown that miRNAs are commonly deregulated in human malignancies, but little is known about the function of miRNA-205 (miR-205) in human breast cancer. The present study investigated the influence of miR-205 on breast cancer malignancy. Methods: The expression level of miR-205 in the MCF7 breast cancer cell line was determined by quantitative (q)RT-PCR. We then analyzed the expression of miR-205 in breast cancer and paired non-tumor tissues. Finally, the roles of miR-205 in regulating tumor proliferation, apoptosis, migration, and target gene expression were studied by MTT assay, flow cytometry, qRT-PCR, Western blotting and luciferase assay. Results: miR-205 was downregulated in breast cancer cells or tissues compared with normal breast cell lines or non-tumor tissues. Overexpression of miR-205 reduced the growth and colony-formation capacity of MCF7 cells by inducing apoptosis. Overexpression of miR-205 inhibited MCF7 cell migration and invasiveness. By bioinformation analysis, miR-205 was predicted to bind to the 3? untranslated regions of human epidermal growth factor receptor (HER)3 mRNA, and upregulation of miR-205 reduced HER3 protein expression. Conclusion: miR-205 is a tumor suppressor in human breast cancer by post-transcriptional inhibition of HER3 expression.

  13. Ground Motion Studies at NuMI

    SciTech Connect

    Mayda M. Velasco; Michal Szleper

    2012-02-20

    Ground motion can cause significant deterioration in the luminosity of a linear collider. Vibration of numerous focusing magnets causes continuous misalignments, which makes the beam emittance grow. For this reason, understanding the seismic vibration of all potential LC sites is essential and related efforts in many sites are ongoing. In this document we summarize the results from the studies specific to Fermilab grounds as requested by the LC project leader at FNAL, Shekhar Mishra in FY04-FY06. The Northwestern group focused on how the ground motion effects vary with depth. Knowledge of depth dependence of the seismic activity is needed in order to decide how deep the LC tunnel should be at sites like Fermilab. The measurements were made in the NuMI tunnel, see Figure 1. We take advantage of the fact that from the beginning to the end of the tunnel there is a height difference of about 350 ft and that there are about five different types of dolomite layers. The support received allowed to pay for three months of salary of Michal Szleper. During this period he worked a 100% of his time in this project. That include one week of preparation: 2.5 months of data taking and data analysis during the full period of the project in order to guarantee that we were recording high quality data. We extended our previous work and made more systematic measurements, which included detailed studies on stability of the vibration amplitudes at different depths over long periods of time. As a consequence, a better control and more efficient averaging out of the daytime variation effects were possible, and a better study of other time dependences before the actual depth dependence was obtained. Those initial measurements were made at the surface and are summarized in Figure 2. All measurements are made with equipment that we already had (two broadband seismometers KS200 from GEOTECH and DL-24 portable data recorder). The offline data analysis took advantage of the full Fourier spectra

  14. Honey Lake Geothermal Area | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Honey Lake Geothermal Area Honey Lake Geothermal Area The Honey Lake geothermal area is located in Lassen County, California and Washoe County, Nevada. There are three geothermal projects actively producing electrical power. They are located at Wendel, Wineagle, and Amedee. Photo of Amedee Geothermal Venture power plant in Amadee, CA

  15. DOE - Office of Legacy Management -- Mitts-Merrill Co - MI 14

    Office of Legacy Management (LM)

    1993 MI.14-2 Site Operations: Reduced thorium metal chunks into particle sized pieces ... Primary Radioactive Materials Handled: Thorium MI.14-1 Radiological Survey(s): Yes - ...

  16. DOE - Office of Legacy Management -- Mitts-Merrel Co - MI 14

    Office of Legacy Management (LM)

    1993 MI.14-2 Site Operations: Reduced thorium metal chunks into particle sized pieces ... Primary Radioactive Materials Handled: Thorium MI.14-1 Radiological Survey(s): Yes - ...

  17. Urban lake sediment chemistry: Lake design, runoff, and watershed impact

    SciTech Connect

    Amalfi, F.A.

    1988-01-01

    Sediments of twenty-two urban lakes and stormwater discharge into five of the impoundments were analyzed for the presence of selected metallic priority pollutants, total petroleum hydrocarbons, and volatile and extractable organic compounds. The concentration (mg/kg dry weight) ranges of metals in lake sediments were: arsenic 7-29, cadmium < 0.5-0.5, chromium 14-55, lead <1-138, selenium <0.01-1.1, silver 0.2-2.1, copper 25-2760, nickel 5-40, and zinc 33.9-239. Concentrations of total petroleum hydrocarbons ranged from 30 to 4400 mg/kg (wet weight). Organic priority pollutants detected in the urban lake impoundments included tetrachlorethylene, 1,1,2-trichloroethane, trichlorofluoromethane, phthalate esters, chloroform, and dichlorobromomethane. Stormwater runoff contained measurable quantities of arsenic, chromium, lead, selenium, copper, nickel, zinc, and petroleum hydrocarbons; whereas organic priority pollutants were not detected. Stormwater runoff pollutant loads indicated that runoff provides a significant contribution of metals and petroleum hydrocarbons to lake sediments.

  18. MiR-125a TNF receptor-associated factor 6 to inhibit osteoclastogenesis

    SciTech Connect

    Guo, Li-Juan; Liao, Lan; Yang, Li; Li, Yu; Jiang, Tie-Jian

    2014-02-15

    MicroRNAs (miRNAs) play important roles in osteoclastogenesis and bone resorption. In the present study, we found that miR-125a was dramatically down-regulated during macrophage colony stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ligand (RANKL) induced osteoclastogenesis of circulating CD14+ peripheral blood mononuclear cells (PBMCs). Overexpression of miR-125a in CD14+ PBMCs inhibited osteoclastogenesis, while inhibition of miR-125a promoted osteoclastogenesis. TNF receptor-associated factor 6 (TRAF6), a transduction factor for RANKL/RANK/NFATc1 signal, was confirmed to be a target of miR-125a. EMSA and ChIP assays confirmed that NFATc1 bound to the promoter of the miR-125a. Overexpression of NFATc1 inhibited miR-125a transcription, and block of NFATc1 expression attenuated RANKL-regulated miR-125a transcription. Here, we reported that miR-125a played a biological function in osteoclastogenesis through a novel TRAF6/ NFATc1/miR-125a regulatory feedback loop. It suggests that regulation of miR-125a expression may be a potential strategy for ameliorating metabolic disease. - Highlights: • MiR-125a was significantly down-regulated in osteoclastogenesis of CD14+ PBMCs. • MiR-125a inhibited osteoclast differentiation by targeting TRAF6. • NFATc1 inhibited miR-125a transciption by binding to the promoter of miR-125a. • TRAF6/NFATc1 and miR-125a form a regulatory feedback loop in osteoclastogenesis.

  19. Soda Lake Geothermal Area | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    of Reservoir: 1219 m1.219 km 0.757 mi 3,999.344 ft 1,333.111 yd 1 Average Depth to Reservoir: 762 m0.762 km 0.473 mi 2,500 ft 833.331 yd Use the "Edit with Form" button at...

  20. Port Huron, MI Liquefied Natural Gas Exports (Million Cubic Feet...

    Energy Information Administration (EIA) (indexed site)

    (Million Cubic Feet) Port Huron, MI Liquefied Natural Gas Exports (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2013 1 2014 1 1 1 1 2 1 1 1 1 1 2015 1 1...

  1. Neutron scattering study of spin ordering and stripe pinning in superconducting <mi>La>1.93<mi>Sr>0.07<mi>CuO>4

    SciTech Connect

    Jacobsen, H.; Zaliznyak, I. A.; Savici, A. T.; Winn, B. L.; Chang, S.; Hücker, M.; Gu, G. D.; Tranquada, J. M.

    2015-11-20

    The relationships among charge order, spin fluctuations, and superconductivity in underdoped cuprates remain controversial. We use neutron scattering techniques to study these phenomena in <mi>La>1.93<mi>Sr>0.07<mi>CuO>4 a superconductor with a transition temperature of Tc = 20 K. At T<< Tc, we find incommensurate spin fluctuations with a quasielastic energy spectrum and no sign of a gap within the energy range from 0.2 to 15 meV. A weak elastic magnetic component grows below ~ 10 K, consistent with results from local probes. Regarding the atomic lattice, we have discovered unexpectedly strong fluctuations of the CuO6 octahedra about Cu-O bonds, which are associated with inequivalent O sites within the CuO2 planes. Moreover, we observed a weak elastic (3 30) superlattice peak that implies a reduced lattice symmetry. The presence of inequivalent O sites rationalizes various pieces of evidence for charge stripe order in underdoped La2-xSrxCuO4. The coexistence of superconductivity with quasi-static spin-stripe order suggests the presence of intertwined orders; however, the rotation of the stripe orientation away from the Cu-O bonds might be connected with evidence for a finite gap at the nodal points of the superconducting gap function.

  2. Blue Lake Rancheria Kicks Off Solar System Construction | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energy Blue Lake Rancheria Kicks Off Solar System Construction Blue Lake Rancheria Kicks Off Solar System Construction May 9, 2016 - 5:54pm Addthis Blue Lake Rancheria Energy Director Jana Ganion flanked by Kernen Construction Site Supervisor Gavin Johnson (left) and Blue Lake Rancheria Facilities Director Neil Harris (right). Photo from Blue Lake Rancheria Blue Lake Rancheria Energy Director Jana Ganion flanked by Kernen Construction Site Supervisor Gavin Johnson (left) and Blue Lake

  3. MiR-145 functions as a tumor suppressor targeting NUAK1 in human intrahepatic cholangiocarcinoma

    SciTech Connect

    Xiong, Xinkui; Sun, Daoyi; Chai, Hao; Shan, Wengang; Yu, Yue; Pu, Liyong; Cheng, Feng

    2015-09-18

    The dysregulation of micro (mi)RNAs is associated with cancer development. The miRNA miR-145 is downregulated in intrahepatic cholangiocarcinoma (ICC); however, its precise role in tumor progression has not yet been elucidated. Novel (nua) kinase family (NUAK)1 functions as an oncogene in various cancers and is a putative target of miR-145 regulation. In this study, we investigated the regulation of NUAK1 by miR-145 in ICC. We found that miR-145 level was significantly decreased in ICC tissue and cell lines, which corresponded with an increase in NUAK1 expression. NUAK1 was found to be a direct target of miR-145 regulation. The overexpression of miR-145 in ICC cell lines inhibited proliferation, growth, and invasion by suppressing NUAK1 expression, which was associated with a decrease in Akt signaling and matrix metalloproteinase protein expression. Similar results were observed by inhibiting NUAK1 expression. These results demonstrate that miR-145 can prevent ICC progression by targeting NUAK1 and its downstream effectors, and can therefore be useful for clinical diagnosis and targeted therapy of ICC. - Highlights: • MiR-145 suppresses ICC proliferation and invasion abilities. • We demonstrated that miR-145 directly targets NUAK1 in ICC. • MiR-145 expression in ICC was associated with Akt signaling and MMPs expression.

  4. Radiosensitizing Effects of Ectopic miR-101 on Non-Small-Cell Lung Cancer Cells Depend on the Endogenous miR-101 Level

    SciTech Connect

    Chen, Susie; Wang Hongyan; Ng, Wooi Loon; Curran, Walter J.; Wang Ya

    2011-12-01

    Purpose: Previously, we showed that ectopic miR-101 could sensitize human tumor cells to radiation by targeting ATM and DNA-PK catalytic subunit (DNA-PKcs) to inhibit DNA repair, as the endogenous miR-101 levels are low in tumors in general. However, the heterogeneity of human cancers may result in an exception. The purpose of this study was to test the hypothesis that a few tumor cell lines with a high level of endogenous miR-101 would prove less response to ectopic miR-101. Methods and Materials: Fourteeen non-small-cell lung cancer (NSCLC) cell lines and one immortalized non-malignant lung epithelial cell line (NL20) were used for comparing endogenous miR-101 levels by real-time reverse transcription-polymerase chain reaction. Based on the different miR-101 levels, four cell lines with different miR-101 levels were chosen for transfection with a green fluorescent protein-lentiviral plasmid encoding miR-101. The target protein levels were measured by using Western blotting. The radiosensitizing effects of ectopic miR-101 on these NSCLC cell lines were determined by a clonogenic assay and xenograft mouse model. Results: The endogenous miR-101 level was similar or lower in 13 NSCLC cell lines but was 11-fold higher in one cell line (H157) than in NL20 cells. Although ectopic miR-101 efficiently decreased the ATM and DNA-PKcs levels and increased the radiosensitization level in H1299, H1975, and A549 cells, it did not change the levels of the miR-101 targets or radiosensitivity in H157 cells. Similar results were observed in xenograft mice. Conclusions: A small number of NSCLC cell lines could have a high level of endogenous miR-101. The ectopic miR-101 was able to radiosensitize most NSCLC cells, except for the NSCLC cell lines that had a much higher endogenous miR-101 level. These results suggest that when we choose one miRNA as a therapeutic tool, the endogenous level of the miRNA in each tumor should be considered.

  5. Steel Creek fish, L-Lake/Steel Creek Biological Monitoring Program, January 1986--December 1991

    SciTech Connect

    Sayers, R.E. Jr.; Mealing, H.G. III

    1992-04-01

    The Savannah River Site (SRS) encompasses 300 sq mi of the Atlantic Coastal plain in west-central South Carolina. The Savannah River forms the western boundary of the site. Five major tributaries of the Savannah River -- Upper Three Runs Creek, Four Mile Creek, Pen Branch, Steel Creek, and Lower Three Runs Creek -- drain the site. All but Upper Three Runs Creek receive, or in the past received, thermal effluents from nuclear production reactors. In 1985, L Lake, a 400-hectare cooling reservoir, was built on the upper reaches of Steel Creek to receive effluent from the restart of L-Reactor, and protect the lower reaches from thermal impacts. The lake has an average width of approximately 600 m and extends along the Steel Creek valley approximately 7000 m from the dam to the headwaters. Water level is maintained at a normal pool elevation of 58 m above mean sea level by overflow into a vertical intake tower that has multilevel discharge gates. The intake tower is connected to a horizontal conduit that passes through the dam and releases water into Steel Creek. The Steel Creek Biological Monitoring Program was designed to meet environmental regulatory requirements associated with the restart of L-Reactor and complements the Biological Monitoring Program for L Lake. This extensive program was implemented to address portions of Section 316(a) of the Clean Water Act. The Department of Energy (DOE) must demonstrate that the operation of L-Reactor will not significantly alter the established aquatic ecosystems.

  6. PPARγ inhibits ovarian cancer cells proliferation through upregulation of miR-125b

    SciTech Connect

    Luo, Shuang; Wang, Jidong; Ma, Ying; Yao, Zhenwei; Pan, Hongjuan

    2015-06-26

    miR-125b has essential roles in coordinating tumor proliferation, angiogenesis, invasiveness, metastasis and chemotherapy recurrence. In ovarian cancer miR-125b has been shown to be downregulated and acts as a tumor suppressor by targeting proto-oncogene BCL3. PPARγ, a multiple functional transcription factor, has been reported to have anti-tumor effects through inhibition of proliferation and induction of differentiation and apoptosis by targeting the tumor related genes. However, it is unclear whether miR-125b is regulated by PPARγ in ovarian cancer. In this study, we demonstrated that the miR-125b downregulated in ovarian cancer tissues and cell lines. Ligands-activated PPARγ suppressed proliferation of ovarian cancer cells and this PPARγ-induced growth inhibition is mediated by the upregulation of miR-125b. PPARγ promoted the expression of miR-125b by directly binding to the responsive element in miR-125b gene promoter region. Thus, our results suggest that PPARγ can induce growth suppression of ovarian cancer by upregulating miR-125b which inhibition of proto-oncogene BCL3. These findings will extend our understanding of the function of PPARγ in tumorigenesis and miR-125b may be a therapeutic intervention of ovarian cancer. - Highlights: • miR-125b is down-regulated in ovarian cancer tissues and cells. • PPARγ upregulates miR-125b and downregulates its target gene BCL3 expression. • Silence of miR-125b attenuates PPARγ-mediated growth suppression of ovarian cancer cells. • PPARγ promotes the transcription of miR-125b via binding to PPARE in miR-125b gene promoter region.

  7. CLEAR LAKE BASIN 2000 PROJECT

    SciTech Connect

    LAKE COUNTY SANITATION DISTRICT

    2003-03-31

    The following is a final report for the Clear Lake Basin 2000 project. All of the major project construction work was complete and this phase generally included final details and testing. Most of the work was electrical. Erosion control activities were underway to prepare for the rainy season. System testing including pump stations, electrical and computer control systems was conducted. Most of the project focus from November onward was completing punch list items.

  8. VEE-0018- In the Matter of Lakes Gas Company

    Energy.gov [DOE]

    On March 12, 1996, the Lakes Gas Company (Lakes) of Forest Lake, Minnesota, filed an Application for Exception with the Office of Hearings and Appeals of the Department of Energy. In its...

  9. Rice Lake Utilities | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Place: Wisconsin Phone Number: 715-234-7004 Website: www.ricelakeutilities.com Facebook: https:www.facebook.compagesCity-of-Rice-Lake-Utilities162786740407997 Outage...

  10. Lake Country Power | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Number: 8004219959 Website: www.lakecountrypower.coopinde Twitter: @LakeCountryPowe Facebook: https:www.facebook.comlakecountrypower Outage Hotline: 8004219959 Outage Map:...

  11. Glacial Lakes Energy | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    search Name: Glacial Lakes Energy Place: Watertown, South Dakota Zip: 57201 Product: Bioethanol producer using corn as feedstock Coordinates: 43.197366, -88.720469 Show Map...

  12. Soda Lake Geothermal Area | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Facility Add a new Operating Power Plant Developing Power Projects: 1 East Soda Lake Geothermal Project ( MW, Phase I - Resource Procurement and Identification) Add a new...

  13. Spirit Lake Wind Farm | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Minnesota Windpower Energy Purchaser AlliantIES Utilities Location Spirit Lake IA Coordinates 43.411381, -95.10075 Show Map Loading map... "minzoom":false,"mappingse...

  14. Great Lakes Biofuels LLC | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Great Lakes Biofuels LLC Place: Madison, Wisconsin Zip: 53704 Sector: Services Product: Biodiesel research, consulting, management distribution and services company. Coordinates:...

  15. Lake Pocotopaug, Connecticut: Energy Resources | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    Lake Pocotopaug, Connecticut: Energy Resources Jump to: navigation, search Equivalent URI DBpedia Coordinates 41.5984325, -72.5103654 Show Map Loading map......

  16. Medicine Lake Geothermal Area | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Page Technique Activity Start Date Activity End Date Reference Material Geothermal Literature Review At Medicine Lake Geothermal Area (1984) Geothermal Literature Review 1984...

  17. Obama Administration Hosts Great Lakes Offshore Wind Workshop in Chicago

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    with Great Lakes Wind Collaborative | Department of Energy Hosts Great Lakes Offshore Wind Workshop in Chicago with Great Lakes Wind Collaborative Obama Administration Hosts Great Lakes Offshore Wind Workshop in Chicago with Great Lakes Wind Collaborative October 28, 2010 - 12:00am Addthis WASHINGTON - The White House Council on Environmental Quality and the U.S. Department of Energy hosted a workshop with the Great Lakes Wind Collaborative in Chicago on October 26 - 27, 2010, focused on the

  18. Similarities in shoreline response to Late Holocene lake-level variations in Lake Michigan

    SciTech Connect

    Thompson, T.A.; Baedke, S.J. )

    1992-01-01

    Beach ridges dating back to 2600 B.P. occur in embayments throughout Lake Michigan. Similarities in their geomorphic development are interpreted to be the product of three scales of lake-level variation. The largest of these embayments is roughly coincident with the Indiana shore of Lake Michigan known as the Toleston Beach. In the western part of the Toleston Beach, more than 150 beach ridges have formed in response to short-term variations in lake level occurring at a quasi-periodic interval of about 30 years. Bundles of five of these ridges merge eastward to form higher relief beach ridges that record an intermediate-term lake-level variation of about 150 years. Both the 30-year and 150-year lake-level events are superimposed on a longer term lake-level variation of about 600 years. Beach-ridge development in northern Lake Michigan reflects a similar response to late Holocene lake-level variations. For example, the southern embayment of the Platte Bay Unit of the Sleeping Bear Dunes National Lakeshore also contains a series of beach ridges that record three scales of lake-level variation. In this area, most of the beach ridges formed between 2600 and 1200 B.P., with individual ridges forming about every 29 years. Also recorded in this embayment are the time equivalent groupings of beach ridges every 150 and 600 years. Although embayments containing beach ridges in Lake Michigan may record different short-term lake-level variations in response to local depositional conditions within the embayment, the 150-year and 600-year variations appear to be represented throughout the lake. Relative lake-level curves for the Toleston Beach and the Platte Bay embayment are displaced by approximately 1.5 m. This displacement is accounted for under current models of isostasy for Lake Michigan.

  19. Lake Gas Recovery Biomass Facility | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Gas Recovery Biomass Facility Jump to: navigation, search Name Lake Gas Recovery Biomass Facility Facility Lake Gas Recovery Sector Biomass Facility Type Landfill Gas Location Cook...

  20. EA-1996: Glass Buttes Radio Station, Lake County, Oregon | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    6: Glass Buttes Radio Station, Lake County, Oregon EA-1996: Glass Buttes Radio Station, Lake County, Oregon SUMMARY The Bureau of Land Management (BLM), with DOE's Bonneville Power...

  1. Stantec Investigates Bat Activity in Atlantic and Great Lakes...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Stantec Investigates Bat Activity in Atlantic and Great Lakes Offshore Regions Stantec Investigates Bat Activity in Atlantic and Great Lakes Offshore Regions October 1, 2013 - ...

  2. Salt Lake Community College | OSTI, US Dept of Energy Office...

    Office of Scientific and Technical Information (OSTI)

    DOE Applauds Salt Lake Community College Science and Technical Programs slccLogo-orange.jpg Salt Lake City, Utah Architectural Technology Biology Biotechnology Biomanufacturing ...

  3. Mercury Vapor At Medicine Lake Area (Kooten, 1987) | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    Medicine Lake Area (Kooten, 1987) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Mercury Vapor At Medicine Lake Area (Kooten, 1987) Exploration...

  4. Ground Gravity Survey At Clear Lake Area (Skokan, 1993) | Open...

    OpenEI (Open Energy Information) [EERE & EIA]

    Ground Gravity Survey At Clear Lake Area (Skokan, 1993) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Ground Gravity Survey At Clear Lake Area...

  5. Summer Lake Hot Springs Space Heating Low Temperature Geothermal...

    OpenEI (Open Energy Information) [EERE & EIA]

    Space Heating Low Temperature Geothermal Facility Jump to: navigation, search Name Summer Lake Hot Springs Space Heating Low Temperature Geothermal Facility Facility Summer Lake...

  6. Salt Lake City, Utah: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Salt Lake City, Utah: Energy Resources (Redirected from Salt Lake City, UT) Jump to: navigation, search Equivalent URI DBpedia Coordinates 40.7607793, -111.8910474 Show Map...

  7. Wall Lake Municipal Utilities Wind Farm | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Municipal Utilities Energy Purchaser Wall Lake Municipal Utilities Location Wall Lake IA Coordinates 42.281965, -95.094098 Show Map Loading map... "minzoom":false,"mappings...

  8. Lake County, Florida: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    2 Climate Zone Subtype A. US Recovery Act Smart Grid Projects in Lake County, Florida City of Leesburg, Florida Smart Grid Project Energy Generation Facilities in Lake County,...

  9. Lake County, Illinois: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    North Chicago, Illinois Old Mill Creek, Illinois Palatine, Illinois Park City, Illinois Port Barrington, Illinois Riverwoods, Illinois Round Lake Beach, Illinois Round Lake...

  10. HERO BX formerly Lake Erie Biofuels | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    HERO BX formerly Lake Erie Biofuels Jump to: navigation, search Name: HERO BX (formerly Lake Erie Biofuels) Place: Erie, Pennsylvania Product: Pennsylvania-based project developer...

  11. City of Mountain Lake, Minnesota (Utility Company) | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    Lake, Minnesota (Utility Company) Jump to: navigation, search Name: City of Mountain Lake Place: Minnesota Phone Number: (507) 427-2999 Website: www.mountainlakemn.comindex.a...

  12. Pressure Temperature Log At Fish Lake Valley Area (DOE GTP) ...

    OpenEI (Open Energy Information) [EERE & EIA]

    Fish Lake Valley Area (DOE GTP) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Pressure Temperature Log At Fish Lake Valley Area (DOE GTP)...

  13. Thermochronometry At Fish Lake Valley Area (DOE GTP) | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    Fish Lake Valley Area (DOE GTP) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Thermochronometry At Fish Lake Valley Area (DOE GTP) Exploration...

  14. Static Temperature Survey At Fish Lake Valley Area (Deymonaz...

    OpenEI (Open Energy Information) [EERE & EIA]

    Fish Lake Valley Area (Deymonaz, Et Al., 2008) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Static Temperature Survey At Fish Lake Valley Area...

  15. Hyperspectral Imaging At Fish Lake Valley Area (Littlefield ...

    OpenEI (Open Energy Information) [EERE & EIA]

    Fish Lake Valley Area (Littlefield & Calvin, 2010) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Hyperspectral Imaging At Fish Lake Valley Area...

  16. Geothermometry At Fish Lake Valley Area (DOE GTP) | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    Fish Lake Valley Area (DOE GTP) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Geothermometry At Fish Lake Valley Area (DOE GTP) Exploration...

  17. Compound and Elemental Analysis At Fish Lake Valley Area (DOE...

    OpenEI (Open Energy Information) [EERE & EIA]

    ENERGYGeothermal Home Exploration Activity: Compound and Elemental Analysis At Fish Lake Valley Area (DOE GTP) Exploration Activity Details Location Fish Lake Valley Area...

  18. Geographic Information System At Fish Lake Valley Area (Deymonaz...

    OpenEI (Open Energy Information) [EERE & EIA]

    Fish Lake Valley Area (Deymonaz, Et Al., 2008) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Geographic Information System At Fish Lake Valley...

  19. Fish Lake Valley Geothermal Area | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Fish Lake Valley Geothermal Area Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Fish Lake Valley Geothermal Area Contents 1 Area Overview 2 History and Infrastructure...

  20. Modeling-Computer Simulations At Fish Lake Valley Area (Deymonaz...

    OpenEI (Open Energy Information) [EERE & EIA]

    Fish Lake Valley Area (Deymonaz, Et Al., 2008) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Modeling-Computer Simulations At Fish Lake Valley...

  1. Geothermal Literature Review At Fish Lake Valley Area (Deymonaz...

    OpenEI (Open Energy Information) [EERE & EIA]

    Fish Lake Valley Area (Deymonaz, Et Al., 2008) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Geothermal Literature Review At Fish Lake Valley...

  2. Lake County, Oregon: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Zone Subtype B. Places in Lake County, Oregon Crump Geyser, Oregon Lakeview, Oregon Paisley, Oregon Retrieved from "http:en.openei.orgwindex.php?titleLakeCounty,Oregon&ol...

  3. Energy Department Supports Efficiency Upgrades in Alaska's Lake...

    Office of Environmental Management (EM)

    Supports Efficiency Upgrades in Alaska's Lake and Peninsula Borough Energy Department Supports Efficiency Upgrades in Alaska's Lake and Peninsula Borough March 24, 2016 - 4:48pm ...

  4. Great Lakes Science Center Wind Farm | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Science Center Wind Farm Jump to: navigation, search Name Great Lakes Science Center Wind Farm Facility Great Lakes Science Center Sector Wind energy Facility Type Community Wind...

  5. Lake Elsinore Pool & Spa Low Temperature Geothermal Facility...

    OpenEI (Open Energy Information) [EERE & EIA]

    Elsinore Pool & Spa Low Temperature Geothermal Facility Jump to: navigation, search Name Lake Elsinore Pool & Spa Low Temperature Geothermal Facility Facility Lake Elsinore Sector...

  6. PYRAMID LAKE RENEWEABLE ENERGY PLAN (Technical Report) | SciTech...

    Office of Scientific and Technical Information (OSTI)

    PYRAMID LAKE RENEWEABLE ENERGY PLAN Citation Details In-Document Search Title: PYRAMID LAKE RENEWEABLE ENERGY PLAN You are accessing a document from the Department of Energy's ...

  7. Lake County Ag Park Greenhouse Low Temperature Geothermal Facility...

    OpenEI (Open Energy Information) [EERE & EIA]

    Ag Park Greenhouse Low Temperature Geothermal Facility Jump to: navigation, search Name Lake County Ag Park Greenhouse Low Temperature Geothermal Facility Facility Lake County Ag...

  8. DOE - Office of Legacy Management -- West Lake Landfill - MO...

    Office of Legacy Management (LM)

    Lake Landfill - MO 05 FUSRAP Considered Sites Site: West Lake Landfill (MO.05) Designated Name: Alternate Name: Location: Evaluation Year: Site Operations: Site Disposition:...

  9. Overview Of The Lake City, California Geothermal System | Open...

    OpenEI (Open Energy Information) [EERE & EIA]

    : GRC; p. () Related Geothermal Exploration Activities Activities (1) Geothermal Literature Review At Lake City Hot Springs Area (Benoit, Et Al., 2004) Areas (1) Lake City Hot...

  10. Analysis of natural gases, AL, AR, FL, GA, IL, IN, IA, KY, LA, MD, MI, MS, MO, NJ, NY, NC, OH, PA, TN, VA, and WV; 1951-1991 (for microcomputers). Data file

    SciTech Connect

    Not Available

    1991-01-01

    The U.S. Bureau of Mines diskette contains analysis and related source data for 2,357 natural gas samples collected from miscellaneous states, which include the following states: Alabama, Arkansas (except Arkoma Basin), Florida, Georgia, Illinois, Indiana, Iowa, Kentucky, Louisiana, Maryland, Michigan, Mississippi, Missouri, New Jersey, New York, North Carolina, Ohio, Pennsylvania, Tennessee, Virginia, and West Virginia. All samples were obtained and analyzed as part of the Bureau's investigations of occurrences of helium in natural gases of countries with free market economies. The survey has been conducted since 1917. The analysis contained on the diskette contain the full range of component analysis data. Five files are on the diskette: READ.ME, MISC.TXT, MISC.DBF, USHEANAL.DBF, and BASINCDE.TXT.

  11. The Lake Charles CCS Project

    SciTech Connect

    Doug Cathro

    2010-06-30

    The Lake Charles CCS Project is a large-scale industrial carbon capture and sequestration (CCS) project which will demonstrate advanced technologies that capture and sequester carbon dioxide (CO{sub 2}) emissions from industrial sources into underground formations. Specifically the Lake Charles CCS Project will accelerate commercialization of large-scale CO{sub 2} storage from industrial sources by leveraging synergy between a proposed petroleum coke to chemicals plant (the LCC Gasification Project) and the largest integrated anthropogenic CO{sub 2} capture, transport, and monitored sequestration program in the U.S. Gulf Coast Region. The Lake Charles CCS Project will promote the expansion of EOR in Texas and Louisiana and supply greater energy security by expanding domestic energy supplies. The capture, compression, pipeline, injection, and monitoring infrastructure will continue to sequester CO{sub 2} for many years after the completion of the term of the DOE agreement. The objectives of this project are expected to be fulfilled by working through two distinct phases. The overall objective of Phase 1 was to develop a fully definitive project basis for a competitive Renewal Application process to proceed into Phase 2 - Design, Construction and Operations. Phase 1 includes the studies attached hereto that will establish: the engineering design basis for the capture, compression and transportation of CO{sub 2} from the LCC Gasification Project, and the criteria and specifications for a monitoring, verification and accounting (MVA) plan at the Hastings oil field in Texas. The overall objective of Phase 2, provided a successful competitive down-selection, is to execute design, construction and operations of three capital projects: (1) the CO{sub 2} capture and compression equipment, (2) a Connector Pipeline from the LLC Gasification Project to the Green Pipeline owned by Denbury and an affiliate of Denbury, and (3) a comprehensive MVA system at the Hastings oil field.

  12. Genome-Wide Analysis of miRNA targets in Brachypodium and Biomass Energy Crops

    SciTech Connect

    Green, Pamela J.

    2015-08-11

    MicroRNAs (miRNAs) contribute to the control of numerous biological processes through the regulation of specific target mRNAs. Although the identities of these targets are essential to elucidate miRNA function, the targets are much more difficult to identify than the small RNAs themselves. Before this work, we pioneered the genome-wide identification of the targets of Arabidopsis miRNAs using an approach called PARE (German et al., Nature Biotech. 2008; Nature Protocols, 2009). Under this project, we applied PARE to Brachypodium distachyon (Brachypodium), a model plant in the Poaceae family, which includes the major food grain and bioenergy crops. Through in-depth global analysis and examination of specific examples, this research greatly expanded our knowledge of miRNAs and target RNAs of Brachypodium. New regulation in response to environmental stress or tissue type was found, and many new miRNAs were discovered. More than 260 targets of new and known miRNAs with PARE sequences at the precise sites of miRNA-guided cleavage were identified and characterized. Combining PARE data with the small RNA data also identified the miRNAs responsible for initiating approximately 500 phased loci, including one of the novel miRNAs. PARE analysis also revealed that differentially expressed miRNAs in the same family guide specific target RNA cleavage in a correspondingly tissue-preferential manner. The project included generation of small RNA and PARE resources for bioenergy crops, to facilitate ongoing discovery of conserved miRNA-target RNA regulation. By associating specific miRNA-target RNA pairs with known physiological functions, the research provides insights about gene regulation in different tissues and in response to environmental stress. This, and release of new PARE and small RNA data sets should contribute basic knowledge to enhance breeding and may suggest new strategies for improvement of biomass energy crops.

  13. DLEU2, frequently deleted in malignancy, functions as a critical host gene of the cell cycle inhibitory microRNAs miR-15a and miR-16-1

    SciTech Connect

    Lerner, Mikael; Harada, Masako; Loven, Jakob; Castro, Juan; Davis, Zadie; Oscier, David; Henriksson, Marie; Sangfelt, Olle; Grander, Dan; Corcoran, Martin M.

    2009-10-15

    The microRNAs miR-15a and miR-16-1 are downregulated in multiple tumor types and are frequently deleted in chronic lymphocytic leukemia (CLL), myeloma and mantle cell lymphoma. Despite their abundance in most cells the transcriptional regulation of miR-15a/16-1 remains unclear. Here we demonstrate that the putative tumor suppressor DLEU2 acts as a host gene of these microRNAs. Mature miR-15a/miR-16-1 are produced in a Drosha-dependent process from DLEU2 and binding of the Myc oncoprotein to two alterative DLEU2 promoters represses both the host gene transcript and levels of mature miR-15a/miR-16-1. In line with a functional role for DLEU2 in the expression of the microRNAs, the miR-15a/miR-16-1 locus is retained in four CLL cases that delete both promoters of this gene and expression analysis indicates that this leads to functional loss of mature miR-15a/16-1. We additionally show that DLEU2 negatively regulates the G1 Cyclins E1 and D1 through miR-15a/miR-16-1 and provide evidence that these oncoproteins are subject to miR-15a/miR-16-1-mediated repression under normal conditions. We also demonstrate that DLEU2 overexpression blocks cellular proliferation and inhibits the colony-forming ability of tumor cell lines in a miR-15a/miR-16-1-dependent way. Together the data illuminate how inactivation of DLEU2 promotes cell proliferation and tumor progression through functional loss of miR-15a/miR-16-1.

  14. Microfluidic Molecular Assay Platform for the Detection of miRNAs...

    Office of Scientific and Technical Information (OSTI)

    Article: Microfluidic Molecular Assay Platform for the Detection of miRNAs, mRNAs, Proteins, and Post-translational Modifications at Single-cell Resolution. Citation Details...

  15. DOE - Office of Legacy Management -- Baker-Perkins Co - MI 13

    Office of Legacy Management (LM)

    Site Disposition: Eliminated - Potential for contamination remote based on limited scope of activities at the site MI.13-3 Radioactive Materials Handled: Yes Primary ...

  16. miR-4295 promotes cell proliferation and invasion in anaplastic thyroid carcinoma via CDKN1A

    SciTech Connect

    Shao, Mingchen; Geng, Yiwei; Lu, Peng; Xi, Ying; Wei, Sidong; Wang, Liuxing; Fan, Qingxia; Ma, Wang

    2015-09-04

    MicroRNAs (miRNAs) play important roles in the pathogenesis of many types of cancers by negatively regulating gene expression at posttranscriptional level. However, the role of microRNAs in anaplastic thyroid carcinoma (ATC), has remained elusive. Here, we identified that miR-4295 promotes ATC cell proliferation by negatively regulates its target gene CDKN1A. In ATC cell lines, CCK-8 proliferation assay indicated that the cell proliferation was promoted by miR-4295, while miR-4295 inhibitor significantly inhibited the cell proliferation. Transwell assay showed that miR-4295 mimics significantly promoted the migration and invasion of ATC cells, whereas miR-4295 inhibitors significantly reduced cell migration and invasion. luciferase assays confirmed that miR-4295 directly bound to the 3'untranslated region of CDKN1A, and western blotting showed that miR-4295 suppressed the expression of CDKN1A at the protein levels. This study indicated that miR-4295 negatively regulates CDKN1A and promotes proliferation and invasion of ATC cell lines. Thus, miR-4295 may represent a potential therapeutic target for ATC intervention. - Highlights: • miR-4295 mimics promote the proliferation and invasion of ATC cells. • miR-4295 inhibitors inhibit the proliferation and invasion of ATC cells. • miR-4295 targets 3′UTR of CDKN1A in ATC cells. • miR-4295 negatively regulates CDKN1A in ATC cells.

  17. Groundwater protection for the NuMI project

    SciTech Connect

    Wehmann, A.; Smart, W.; Menary, S.; Hylen, J.; Childress, S.

    1997-10-01

    The physics requirements for the long base line neutrino oscillation experiment MINOS dictate that the NuMI beamline be located in the aquifer at Fermilab. A methodology is described for calculating the level of radioactivation of groundwater caused by operation of this beamline. A conceptual shielding design for the 750 meter long decay pipe is investigated which would reduce radioactivation of the groundwater to below government standards. More economical shielding designs to meet these requirements are being explored. Also, information on local geology, hydrogeology, government standards, and a glossary have been included.

  18. Stochastic Forecasting of Algae Blooms in Lakes (Book) | SciTech...

    Office of Scientific and Technical Information (OSTI)

    Springer Proceedings in Mathematics & Statistics, 28:99-108 Publisher: JA Ferreira, et al; Springer, New York, NY, United States(US). Research Org: Pacific Northwest National ...

  19. MiR-153 inhibits migration and invasion of human non-small-cell lung cancer by targeting ADAM19

    SciTech Connect

    Shan, Nianxi; Shen, Liangfang; Wang, Jun; He, Dan; Duan, Chaojun

    2015-01-02

    Highlights: • Decreased miR-153 and up-regulated ADAM19 are correlated with NSCLC pathology. • MiR-153 inhibits the proliferation and migration and invasion of NSCLC cells in vitro. • ADAM19 is a direct target of miR-153. • ADAM19 is involved in miR-153-suppressed migration and invasion of NSCLC cells. - Abstract: MiR-153 was reported to be dysregulated in some human cancers. However, the function and mechanism of miR-153 in lung cancer cells remains unknown. In this study, we investigated the role of miR-153 in human non-small-cell lung cancer (NSCLC). Using qRT-PCR, we demonstrated that miR-153 was significantly decreased in clinical NSCLC tissues and cell lines, and downregulation of miR-153 was significantly correlated with lymph node status. We further found that ectopic expression of miR-153 significantly inhibited the proliferation and migration and invasion of NSCLC cells in vitro, suggesting that miR-153 may be a novel tumor suppressor in NSCLC. Further integrated analysis revealed that ADAM19 is as a direct and functional target of miR-153. Luciferase reporter assay demonstrated that miR-153 directly targeted 3′UTR of ADAM19, and correlation analysis revealed an inverse correlation between miR-153 and ADAM19 mRNA levels in clinical NSCLC tissues. Knockdown of ADAM19 inhibited migration and invasion of NSCLC cells which was similar with effects of overexpression of miR-153, while overexpression of ADAM19 attenuated the function of miR-153 in NSCLC cells. Taken together, our results highlight the significance of miR-153 and ADAM19 in the development and progression of NSCLC.

  20. miR-129 suppresses tumor cell growth and invasion by targeting PAK5 in hepatocellular carcinoma

    SciTech Connect

    Zhai, Jian; Qu, Shuping; Li, Xiaowei; Zhong, Jiaming; Chen, Xiaoxia; Qu, Zengqiang; Wu, Dong

    2015-08-14

    Emerging evidence suggests that microRNAs (miRNAs) play important roles in regulating HCC development and progression; however, the mechanisms by which their specific functions and mechanisms remained to be further explored. miR-129 has been reported in gastric cancers, lung cancer and colon cancer. In this study, we disclosed a new tumor suppresser function of miR-129 in HCC. We also found the downregulation of miR-129 occurred in nearly 3/4 of the tumors examined (56/76) compared with adjacent nontumorous tissues, which was more importantly, correlated to the advanced stage and vascular invasion. We then demonstrated that miR-129 overexpression attenuated HCC cells proliferation and invasion, inducing apoptosis in vitro. Moreover, we used miR-129 antagonist and found that anti-miR-129 promoted HCC cells malignant phenotypes. Mechanistically, our further investigations revealed that miR-129 suppressed cell proliferation and invasion by targeting the 3’-untranslated region of PAK5, as well as miR-129 silencing up-regulated PAK5 expression. Moreover, miR-129 expression was inversely correlated with PAK5 expression in 76 cases of HCC samples. RNA interference of PAK5 attenuated anti-miR-129 mediated cell proliferation and invasion in HCC cells. Taken together, these results demonstrated that miR-129 suppressed tumorigenesis and progression by directly targeting PAK5, defining miR-129 as a potential treatment target for HCC. - Highlights: • Decreased of miR-129 is found in HCC and associated with advanced stage and metastasis. • miR-129 suppresses proliferation and invasion of HCC cells. • miR-129 directly targets the 3′ UTR of PAK5 and diminishes PAK5 expression. • PAK5 is involved in miR-129 mediated suppression functions.

  1. Transcriptional regulation of miR-146b by C/EBPβ LAP2 in esophageal cancer cells

    SciTech Connect

    Li, Junxia; Shan, Fabo; Xiong, Gang; Wang, Ju-Ming; Wang, Wen-Lin; Xu, Xueqing; Bai, Yun

    2014-03-28

    Highlights: • MiR-146b promotes esophageal cancer cell proliferation. • MiR-146b inhibits esophageal cancer cell apoptosis. • C/EBPβ directly binds to miR-146b promoter conserved region. • MiR-146b is up-regulated by C/EBPβ LAP2 transcriptional activation. - Abstract: Recent clinical study indicated that up-regulation of miR-146b was associated with poor overall survival of patients in esophageal squamous cell carcinoma. However, the underlying mechanism of miR-146b dysregulation remains to be explored. Here we report that miR-146b promotes cell proliferation and inhibits cell apoptosis in esophageal cancer cell lines. Mechanismly, two C/EBPβ binding motifs are located in the miR-146b promoter conserved region. Among the three isoforms of C/EBPβ, C/EBPβ LAP2 positively regulated miR-146b expression and increases miR-146b levels in a dose-dependent manner through transcription activation of miR-146b gene. Together, these results suggest a miR-146b regulatory mechanism involving C/EBPβ, which may contribute to the up-regulation of miR-146b in esophageal squamous cell carcinoma.

  2. miR-1297 mediates PTEN expression and contributes to cell progression in LSCC

    SciTech Connect

    Li, Xin; Wang, Hong-liang; Peng, Xin; Zhou, Hui-fang; Wang, Xin

    2012-10-19

    Highlights: Black-Right-Pointing-Pointer miR-1297 was found to be overexpressed in LSCC and contribute to the cell progression. Black-Right-Pointing-Pointer PTEN was confirmed to be a target gene of miR-1297. Black-Right-Pointing-Pointer Downregulation of PTEN can rescue the proliferation and invasion ability of miR-1297 downregulated Hep-2 cells. Black-Right-Pointing-Pointer Downregulation of miR-1297 inhibits tumor growth in vivo. -- Abstract: MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression after transcription, and are involved in cancer development. Laryngeal squamous cell carcinoma (LSCC) is one of the most common malignant neoplasms with increasing incidence in recent years. In this paper, we report the overexpression of miR-1297 in LSCC and Hep-2 cells. In addition, PTEN was identified to be directly regulated by miR-1297 through western blot and luciferase activity assay. Furthermore, downregulation of miR-1297 in Hep-2 cells was shown to inhibit cancer cell proliferation, migration, and tumor genesis. Our results document a new epigenetic mechanism for PTEN regulation in LSCC, which is crucial for the development of these tumors.

  3. miR-30a suppresses breast cancer cell proliferation and migration by targeting Eya2

    SciTech Connect

    Fu, Jing; Xu, Xiaojie; Kang, Lei; Zhou, Liying; Wang, Shibin; Lu, Juming; Cheng, Long; Fan, Zhongyi; Yuan, Bin; Tian, Peirong; Zheng, Xiaofei; Yu, Chengze; Ye, Qinong; Lv, Zhaohui

    2014-03-07

    Highlights: • miR-30a represses Eya2 expression by binding to the 3′-untranslated region of Eya2. • The miR-30a/EYA2 axis regulates breast cancer cell proliferation and migration. • The miR-30a/EYA2 axis modulates G1/S cell cycle progression. • The miR-30a/EYA2 axis is dysregulated in breast cancer patients. - Abstract: Eye absent (Eya) proteins are involved in cell fate determination in a broad spectrum of cells and tissues. Aberrant expression of Eya2 has been documented in a variety of cancers and correlates with clinical outcome. However, whether microRNAs (miRNAs) can regulate Eya2 expression remains unknown. Here, we show that miR-30a represses Eya2 expression by binding to the 3′-untranslated region of Eya2. Overexpression of Eya2 in miR-30a-transfected breast cancer cells effectively rescued the inhibition of cell proliferation and migration caused by miR-30a. Knockdown of Eya2 by small-interfering RNA (siRNA) in breast cancer cells mimicked the effect induced by miR-30a and abolished the ability of miR-30a to regulate breast cancer cell proliferation and migration. The miR-30a/Eya2 axis could regulate G1/S cell cycle progression, accompanied by the modulation of expression of cell cycle-related proteins, including cyclin A, cyclin D1, cyclin E, and c-Myc. Moreover, miR-30a expression was downregulated in breast cancer patients, and negatively correlated with Eya2, which was upregulated in breast cancer patients. These data suggest that the miR-30a/Eya2 axis may play an important role in breast cancer development and progression and that miR-30a activation or Eya2 inhibition may be a useful strategy for cancer treatment.

  4. National Science Foundation, Lake Hoare, Antarctica | Department...

    Office of Environmental Management (EM)

    National Science Foundation, Lake Hoare, Antarctica Photo of a Photovoltaic System Located ... The photovoltaic system (PV) that was installed at this site is 1.2 kW PV and was one of ...

  5. Salt Lake City- High Performance Buildings Requirement

    Energy.gov [DOE]

    Salt Lake City's mayor issued an executive order in July 2005 requiring that all public buildings owned and controlled by the city be built or renovated to meet the requirements of LEED "silver"...

  6. Solar on Salt Lake City Convention Center

    Energy.gov [DOE]

    This photograph features the Calvin L. Rampton Salt Palace Convention Center, which will soon become a solar power-producing giant. Salt Lake County and its project partners announced plans to...

  7. Lake Mills Light & Water | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Light & Water Jump to: navigation, search Name: Lake Mills Light & Water Place: Wisconsin Phone Number: (920) 648-4026 Website: www.lakemillslw.com Outage Hotline: (920) 648-4026...

  8. Clear Lake Cogeneration LP | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Cogeneration LP Jump to: navigation, search Name: Clear Lake Cogeneration LP Place: Idaho Phone Number: 281-474-7611 Outage Hotline: 281-474-7611 References: EIA Form EIA-861 Final...

  9. miR-21 modulates resistance of HR-HPV positive cervical cancer cells to radiation through targeting LATS1

    SciTech Connect

    Liu, Shikai; Song, Lili Zhang, Liang; Zeng, Saitian; Gao, Fangyuan

    2015-04-17

    Although multiple miRNAs are found involved in radioresistance development in HR-HPV positive (+) cervical cancer, only limited studies explored the regulative mechanism of the miRNAs. miR-21 is one of the miRNAs significantly upregulated in HR-HPV (+) cervical cancer is also significantly associated with radioresistance. However, the detailed regulative network of miR-21 in radioresistance is still not clear. In this study, we confirmed that miR-21 overexpression was associated with higher level of radioresistance in HR-HPV (+) cervical cancer patients and thus decided to further explore its role. Findings of this study found miR-21 can negatively affect radiosensitivity of HR-HPV (+) cervical cancer cells and decrease radiation induced G2/M block and increase S phase accumulation. By using dual luciferase assay, we verified a binding site between miR-21 and 3′-UTR of large tumor suppressor kinase 1 (LATS1). Through direct binding, miR-21 can regulate LATS1 expression in cervical cancer cells. LATS1 overexpression can reverse miR-21 induced higher colony formation rate and also reduced miR-21 induced S phase accumulation and G2/M phase block reduction under radiation treatment. These results suggested that miR-21-LATS1 axis plays an important role in regulating radiosensitivity. - Highlights: • miR-21 is highly expressed in HR-HPV (+) radioresistant cervical cancer patients. • miR-21 can negatively affect radiosensitivity of HR-HPV (+) cervical cancer cells. • miR-21 can decrease radiation induced G2/M block and increase S phase accumulation. • miR-21 modulates radiosensitivity cervical cancer cell by directly targeting LATS1.

  10. miR-92a is upregulated in cervical cancer and promotes cell proliferation and invasion by targeting FBXW7

    SciTech Connect

    Zhou, Chuanyi; Shen, Liangfang; Mao, Lei; Wang, Bing; Li, Yang; Yu, Huizhi

    2015-02-27

    MicroRNAs (miRNAs) are involved in the cervical carcinogenesis and progression. In this study, we investigated the role of miR-92a in progression and invasion of cervical cancer. MiR-92a was significantly upregulated in cervical cancer tissues and cell lines. Overexpression of miR-92a led to remarkably enhanced proliferation by promoting cell cycle transition from G1 to S phase and significantly enhanced invasion of cervical cancer cells, while its knockdown significantly reversed these cellular events. Bioinformatics analysis suggested F-box and WD repeat domain-containing 7 (FBXW7) as a novel target of miR-92a, and miR-92a suppressed the expression level of FBXW7 mRNA by direct binding to its 3′-untranslated region (3′UTR). Expression of miR-92a was negatively correlated with FBXW7 in cervical cancer tissues. Furthermore, Silencing of FBXW7 counteracted the effects of miR-92a suppression, while its overexpression reversed oncogenic effects of miR-92a. Together, these findings indicate that miR-92a acts as an onco-miRNA and may contribute to the progression and invasion of cervical cancer, suggesting miR-92a as a potential novel diagnostic and therapeutic target of cervical cancer. - Highlights: • miR-92a is elevated in cervical cancer tissues and cell lines. • miR-92a promotes cervical cancer cell proliferation, cell cycle transition from G1 to S phase and invasion. • FBXW7 is a direct target of miR-92a. • FBXW7 counteracts the oncogenic effects of miR-92a on cervical cancer cells.

  11. Dry lake reveals evidence of Southwestern 'megadroughts'

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Dry lake reveals evidence of Southwestern 'megadroughts' Dry lake reveals evidence of Southwestern 'megadroughts' A portion of the research indicates that an ancient period of warming may be analogous to natural present-day climate conditions. February 28, 2011 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma

  12. Lake Erie Connector Project Environmental Assessment Draft

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Volume 1 - Main Document U.S. Department of Energy Office of Electricity Delivery and Energy Reliability Washington DC June 2016 Cover Photo Credits http://www.itclakeerieconnector.com/ DRAFT LAKE ERIE CONNECTOR PROJECT ENVIRONMENTAL ASSESSMENT Volume 1-Main Document DOE/EA-2019 U.S. DEPARTMENT OF ENERGY OFFICE OF ELECTRICITY DELIVERY AND ENERGY RELIABILITY COOPERATING AGENCY U.S. ARMY CORPS OF ENGINEERS This Page Intentionally Left Blank Lake Erie Connector Project Draft Environmental

  13. Marysville, MI Natural Gas Pipeline Imports From Canada (Million Cubic

    Energy Information Administration (EIA) (indexed site)

    Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 10 1,827 135 2000's NA NA 74 0 303 0 24 876 2,252 5,651 2010's 5,694 9,946 8,099 2,337 4,650 1,961 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Natural Gas Pipeline Imports by Point of Entry Marysville, MI Natural Gas Imports by Pipeli

  14. Marysville, MI Natural Gas Pipeline Imports From Canada (Dollars per

    Energy Information Administration (EIA) (indexed site)

    Thousand Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 3.48 2.17 2.06 2000's NA NA 3.95 -- 7.80 -- 7.07 7.59 8.59 3.80 2010's 4.44 4.42 2.99 4.15 6.86 2.73 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Price of Natural Gas Pipeline Imports by Point of Entry Marysville, MI Natural Gas

  15. NuMI proton kicker extraction magnet termination resistor system

    SciTech Connect

    Reeves, S.R.; Jensen, C.C.; /Fermilab

    2005-05-01

    The temperature stability of the kicker magnet termination resistor assembly directly affects the field flatness and amplitude stability. Comprehensive thermal enhancements were made to the existing Main Injector resistor assembly design to satisfy NuMI performance specifications. Additionally, a fluid-processing system utilizing Fluorinert{reg_sign} FC-77 high-voltage dielectric was built to precisely control the setpoint temperature of the resistor assembly from 70 to 120F, required to maintain constant resistance during changing operational modes. The Fluorinert{reg_sign} must be continually processed to remove hazardous breakdown products caused by radiation exposure to prevent chemical attack of system components. Design details of the termination resistor assembly and Fluorinert{reg_sign} processing system are described. Early performance results will be presented.

  16. Non-canonical microRNAs miR-320 and miR-702 promote proliferation in Dgcr8-deficient embryonic stem cells

    SciTech Connect

    Kim, Byeong-Moo; Choi, Michael Y.

    2012-09-21

    Highlights: Black-Right-Pointing-Pointer Embryonic stem cells (ESCs) lacking non-canonical miRNAs proliferate slower. Black-Right-Pointing-Pointer miR-320 and miR-702 are two non-canonical miRNAs expressed in ESCs. Black-Right-Pointing-Pointer miR-320 and miR-702 promote proliferation of Dgcr8-deficient ESCs. Black-Right-Pointing-Pointer miR-320 targets p57 and helps to release Dgcr8-deficient ESCs from G1 arrest. Black-Right-Pointing-Pointer miR-702 targets p21 and helps to release Dgcr8-deficient ESCs from G1 arrest. -- Abstract: MicroRNAs are known to contribute significantly to stem cell phenotype by post-transcriptionally regulating gene expression. Most of our knowledge of microRNAs comes from the study of canonical microRNAs that require two sequential cleavages by the Drosha/Dgcr8 heterodimer and Dicer to generate mature products. In contrast, non-canonical microRNAs bypass the cleavage by the Drosha/Dgcr8 heterodimer within the nucleus but still require cytoplasmic cleavage by Dicer. The function of non-canonical microRNAs in embryonic stem cells (ESCs) remains obscure. It has been hypothesized that non-canonical microRNAs have important roles in ESCs based upon the phenotypes of ESC lines that lack these specific classes of microRNAs; Dicer-deficient ESCs lacking both canonical and non-canonical microRNAs have much more severe proliferation defect than Dgcr8-deficient ESCs lacking only canonical microRNAs. Using these cell lines, we identified two non-canonical microRNAs, miR-320 and miR-702, that promote proliferation of Dgcr8-deficient ESCs by releasing them from G1 arrest. This is accomplished by targeting the 3 Prime -untranslated regions of the cell cycle inhibitors p57 and p21 and thereby inhibiting their expression. This is the first report of the crucial role of non-canonical microRNAs in ESCs.

  17. miR-182 targets CHL1 and controls tumor growth and invasion in papillary thyroid carcinoma

    SciTech Connect

    Zhu, Hongling; Fang, Jin; Zhang, Jichen; Zhao, Zefei; Liu, Lianyong; Wang, Jingnan; Xi, Qian; Gu, Mingjun

    2014-07-18

    Highlights: miR-182 and CHL1 expression patterns are negatively correlated. CHL1 is a direct target of miR-182 in PTC cells. miR-182 suppression inhibits PTC cell growth and invasion. CHL1 is involved in miR-182-mediated cell behavior. - Abstract: In this study, we investigated the role and underlying mechanism of action of miR-182 in papillary thyroid carcinoma (PTC). Bioinformatics analysis revealed close homolog of LI (CHL1) as a potential target of miR-182. Upregulation of miR-182 was significantly correlated with CHL1 downregulation in human PTC tissues and cell lines. miR-182 suppressed the expression of CHL1 mRNA through direct targeting of the 3?-untranslated region (3?-UTR). Downregulation of miR-182 suppressed growth and invasion of PTC cells. Silencing of CHL1 counteracted the effects of miR-182 suppression, while its overexpression mimicked these effects. Our data collectively indicate that miR-182 in PTC promotes cell proliferation and invasion through direct suppression of CHL1, supporting the potential utility of miR-182 inhibition as a novel therapeutic strategy against PTC.

  18. Lake Granbury and Lake Whitney Assessment Initiative Final Scientific/Technical Report Summary

    SciTech Connect

    Harris, B.L.; Roelke, Daniel; Brooks, Bryan; Grover, James

    2010-10-11

    A team of Texas AgriLife Research, Baylor University and University of Texas at Arlington researchers studied the biology and ecology of Prymnesium parvum (golden algae) in Texas lakes using a three-fold approach that involved system-wide monitoring, experimentation at the microcosm and mesocosm scales, and mathematical modeling. The following are conclusions, to date, regarding this organism??s ecology and potential strategies for mitigation of blooms by this organism. In-lake monitoring revealed that golden algae are present throughout the year, even in lakes where blooms do not occur. Compilation of our field monitoring data with data collected by Texas Parks and Wildlife and Brazos River Authority (a period spanning a decade) revealed that inflow and salinity variables affect bloom formations. Thresholds for algae populations vary per lake, likely due to adaptations to local conditions, and also to variations in lake-basin morphometry, especially the presence of coves that may serve as hydraulic storage zones for P. parvum populations. More specifically, our in-lake monitoring showed that the highly toxic bloom that occurred in Lake Granbury in the winter of 2006/2007 was eliminated by increased river inflow events. The bloom was flushed from the system. The lower salinities that resulted contributed to golden algae not blooming in the following years. However, flushing is not an absolute requirement for bloom termination. Laboratory experiments have shown that growth of golden algae can occur at salinities ~1-2 psu but only when temperatures are also low. This helps to explain why blooms are possible during winter months in Texas lakes. Our in-lake experiments in Lake Whitney and Lake Waco, as well as our laboratory experiments, revealed that cyanobacteria, or some other bacteria capable of producing algicides, were able to prevent golden algae from blooming. Identification of this organism is a high priority as it may be a key to managing golden algae blooms

  19. Downregulation of miRNA-30c and miR-203a is associated with hepatitis C virus core protein-induced epithelial–mesenchymal transition in normal hepatocytes and hepatocellular carcinoma cells

    SciTech Connect

    Liu, Dongjing; Wu, Jilin; Liu, Meizhou; Yin, Hui; He, Jiantai; Zhang, Bo

    2015-09-04

    Hepatitis C virus (HCV) Core protein has been demonstrated to induce epithelial–mesenchymal transition (EMT) and is associated with cancer progression of hepatocellular carcinoma (HCC). However, how the Core protein regulates EMT is still unclear. In this study, HCV Core protein was overexpressed by an adenovirus. The protein levels of EMT markers were measured by Western blot. The xenograft animal model was established by inoculation of HepG2 cells. Results showed that ectopic expression of HCV core protein induced EMT in L02 hepatocytes and HepG2 tumor cells by upregulating vimentin, Sanl1, and Snal2 expression and downregulating E-cadherin expression. Moreover, Core protein downregulated miR-30c and miR-203a levels in L02 and HepG2 cells, but artificial expression of miR-30c and miR-203a reversed Core protein-induced EMT. Further analysis showed that ectopic expression of HCV core protein stimulated cell proliferation, inhibited apoptosis, and increased cell migration, whereas artificial expression of miR-30c and miR-203a significantly reversed the role of Core protein in these cell functions in L02 and HepG2 cells. In the HepG2 xenograft tumor models, artificial expression of miR-30c and miR-203a inhibited EMT and tumor growth. Moreover, L02 cells overexpressing Core protein can form tumors in nude mice. In HCC patients, HCV infection significantly shortened patients' survival time, and loss of miR-30c and miR-203 expression correlated with poor survival. In conclusion, HCV core protein downregulates miR-30c and miR-203a expression, which results in activation of EMT in normal hepatocytes and HCC tumor cells. The Core protein-activated-EMT is involved in the carcinogenesis and progression of HCC. Loss of miR-30c and miR-203a expression is a marker for the poor prognosis of HCC. - Highlights: • HCV core protein downregulates miR-30c and miR-203a expression. • Downregulation of miR-30c and miR-203a activates EMT. • Activated-EMT is involved in the

  20. miR-128 and its target genes in tumorigenesis and metastasis

    SciTech Connect

    Li, Molin, E-mail: molin_li@hotmail.com [Dalian Medical University, Dalian 116044 (China); Fu, Weiming [Center for Food Safety and Environmental Technology, Guangzhou Institute of Advanced Technology, Chinese Academy of Sciences, Guangzhou 511458 (China); Wo, Lulu; Shu, Xiaohong [Dalian Medical University, Dalian 116044 (China); Liu, Fang [The second affiliated hospital of Dalian Medical University, Dalian 116023 (China); Li, Chuangang, E-mail: li_chuangang@sina.com [The second affiliated hospital of Dalian Medical University, Dalian 116023 (China)

    2013-12-10

    MicroRNAs (miRNAs) are a class of endogenous, non-coding, 1824 nucleotide length single-strand RNAs that could modulate gene expression at post-transcriptional level. Previous studies have shown that miR-128 enriched in the brain plays an important role in the development of nervous system and the maintenance of normal physical functions. Aberrant expression of miR-128 has been detected in many types of human tumors and its validated target genes are involved in cancer-related biological processes such as cell proliferation, differentiation and apoptosis. In this review, we will summarize the roles of miR-128 and its target genes in tumorigenesis and metastasis. - Highlights: Aberrant expression of miR-128 can be observed in many kinds of malignant tumors. The molecular mechanisms regulating miR-128 expression are elucidated. Roles of miR-128 and its target genes in tumorigenesis and metastasis are summarized.

  1. miR-125b inhibits osteoblastic differentiation by down-regulation of cell proliferation

    SciTech Connect

    Mizuno, Yosuke; Yagi, Ken; Tokuzawa, Yoshimi; Kanesaki-Yatsuka, Yukiko; Suda, Tatsuo; Katagiri, Takenobu; Fukuda, Toru; Maruyama, Masayoshi; Okuda, Akihiko; Amemiya, Tomoyuki; Kondoh, Yasumitsu; Tashiro, Hideo; Okazaki, Yasushi

    2008-04-04

    Although various microRNAs regulate cell differentiation and proliferation, no miRNA has been reported so far to play an important role in the regulation of osteoblast differentiation. Here we describe the role of miR-125b in osteoblastic differentiation in mouse mesenchymal stem cells, ST2, by regulating cell proliferation. The expression of miR-125b was time-dependently increased in ST2 cells, and the increase in miR-125b expression was attenuated in osteoblastic-differentiated ST2 cells induced by BMP-4. The transfection of exogenous miR-125b inhibited proliferation of ST2 cells and caused inhibition of osteoblastic differentiation. In contrast, when the endogenous miR-125b was blocked by transfection of its antisense RNA molecule, alkaline phosphatase activity after BMP-4 treatment was elevated. These results strongly suggest that miR-125b is involved in osteoblastic differentiation through the regulation of cell proliferation.

  2. Energy and water in the Great Lakes.

    SciTech Connect

    Tidwell, Vincent Carroll

    2011-11-01

    The nexus between thermoelectric power production and water use is not uniform across the U.S., but rather differs according to regional physiography, demography, power plant fleet composition, and the transmission network. That is, in some regions water demand for thermoelectric production is relatively small while in other regions it represents the dominate use. The later is the case for the Great Lakes region, which has important implications for the water resources and aquatic ecology of the Great Lakes watershed. This is today, but what about the future? Projected demographic trends, shifting lifestyles, and economic growth coupled with the threat of global climate change and mounting pressure for greater U.S. energy security could have profound effects on the region's energy future. Planning for such an uncertain future is further complicated by the fact that energy and environmental planning and regulatory decisionmaking is largely bifurcated in the region, with environmental and water resource concerns generally taken into account after new energy facilities and technologies have been proposed, or practices are already in place. Based on these confounding needs, the objective of this effort is to develop Great Lakes-specific methods and tools to integrate energy and water resource planning and thereby support the dual goals of smarter energy planning and development, and protection of Great Lakes water resources. Guiding policies for this planning are the Great Lakes and St. Lawrence River Basin Water Resources Compact and the Great Lakes Water Quality Agreement. The desired outcome of integrated energy-water-aquatic resource planning is a more sustainable regional energy mix for the Great Lakes basin ecosystem.

  3. NY Green Bank

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Bank Panel 1: Attracting and Maintaining Capital for Energy Transmission, Storage, and ... clean energy capital markets for large scale infrastructure are deep and robust. ...

  4. Training Session: Buffalo, NY

    Energy.gov [DOE]

    This 3.5-hour training provides builders with a comprehensive review of zero energy-ready home construction including the business case, detailed specifications, and opportunities to be recognized...

  5. NY-%-3 P

    Office of Legacy Management (LM)

    ... Liquids (containing the uranium) from the precipitation went to the lead removal tanks, and the slurry was transferred to the lead recovery tanks before disposal. The process was ...

  6. ACIM-~ NY.49

    Office of Legacy Management (LM)

    1 FGCillED INVOLVEYYT AT SITE ...---...---... . i Control 3 &alth Physics Protection 0 AECMED managed Operations cj Little or None G AECMED responsible for c ...

  7. miR-15a/16 Enhances Radiation Sensitivity of Non-Small Cell Lung Cancer

    Office of Scientific and Technical Information (OSTI)

    Cells by Targeting the TLR1/NF-κB Signaling Pathway (Journal Article) | SciTech Connect miR-15a/16 Enhances Radiation Sensitivity of Non-Small Cell Lung Cancer Cells by Targeting the TLR1/NF-κB Signaling Pathway Citation Details In-Document Search Title: miR-15a/16 Enhances Radiation Sensitivity of Non-Small Cell Lung Cancer Cells by Targeting the TLR1/NF-κB Signaling Pathway Purpose: Many miRNAs have been identified as essential issues and core determining factors in tumor radiation.

  8. THERMODYNAMICS OF PARTIALLY FROZEN COOLING LAKES

    SciTech Connect

    Garrett, A.; Casterline, M.; Salvaggio, C.

    2010-01-05

    The Rochester Institute of Technology (RIT) collected visible, SWIR, MWIR and LWIR imagery of the Midland (Michigan) Cogeneration Ventures Plant from aircraft during the winter of 2008-2009. RIT also made ground-based measurements of lake water and ice temperatures, ice thickness and atmospheric variables. The Savannah River National Laboratory (SRNL) used the data collected by RIT and a 3-D hydrodynamic code to simulate the Midland cooling lake. The hydrodynamic code was able to reproduce the time distribution of ice coverage on the lake during the entire winter. The simulations and data show that the amount of ice coverage is almost linearly proportional to the rate at which heat is injected into the lake (Q). Very rapid melting of ice occurs when strong winds accelerate the movement of warm water underneath the ice. A snow layer on top of the ice acts as an insulator and decreases the rate of heat loss from the water below the ice to the atmosphere above. The simulated ice cover on the lake was not highly sensitive to the thickness of the snow layer. The simplicity of the relationship between ice cover and Q and the weak responses of ice cover to snow depth over the ice are probably attributable to the negative feedback loop that exists between ice cover and heat loss to the atmosphere.

  9. Curiosity Rover confirms existence of a large ancient lake on...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Curiosity Rover confirms existence of a large ancient lake on Mars Curiosity Rover confirms existence of a large ancient lake on Mars New findings released today in the journal ...

  10. City of Lake Crystal, Minnesota (Utility Company) | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    Name: City of Lake Crystal Place: Minnesota Phone Number: (605)256-6536 Website: www.ci.lake-crystal.mn.usinde Outage Hotline: (800)520-4746 References: EIA Form EIA-861 Final...

  11. City of Shasta Lake, California (Utility Company) | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    Name: City of Shasta Lake Place: California Phone Number: 530-275-7400 Website: www.ci.shasta-lake.ca.usindex Outage Hotline: 530-275-7400 References: EIA Form EIA-861 Final...

  12. Alternative Fuels Data Center: Salt Lake City Fuels Vehicles...

    Alternative Fuels and Advanced Vehicles Data Center

    Salt Lake City Fuels Vehicles With Natural Gas to someone by E-mail Share Alternative Fuels Data Center: Salt Lake City Fuels Vehicles With Natural Gas on Facebook Tweet about ...

  13. Lake Benton II Wind Farm | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    II Wind Farm Jump to: navigation, search Name Lake Benton II Wind Farm Facility Lake Benton II Sector Wind energy Facility Type Commercial Scale Wind Facility Status In Service...

  14. Meadow Lake II (3Q10) | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    II (3Q10) Jump to: navigation, search Name Meadow Lake II (3Q10) Facility Meadow Lake II (3Q10) Sector Wind energy Facility Type Commercial Scale Wind Facility Status In Service...

  15. Dry Lake II Wind Farm | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    II Wind Farm Jump to: navigation, search Name Dry Lake II Wind Farm Facility Dry Lake II Sector Wind energy Facility Type Commercial Scale Wind Facility Status In Service Owner...

  16. Obama Administration Hosts Great Lakes Offshore Wind Workshop...

    Office of Environmental Management (EM)

    Department of Energy hosted a workshop with the Great Lakes Wind Collaborative in Chicago on October 26 - 27, 2010, focused on the siting of offshore wind power in the Great Lakes. ...

  17. Soda Lake, Nevada: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    This article is a stub. You can help OpenEI by expanding it. Soda Lake is a lake in Churchill County, Nevada. References USGS GNIS Retrieved from "http:en.openei.orgw...

  18. JW Great Lakes Wind LLC | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    JW Great Lakes Wind LLC Jump to: navigation, search Name: JW Great Lakes Wind LLC Place: Cleveland, Ohio Zip: 44114-4420 Sector: Wind energy Product: Ohio based subsidiary of Juwi...

  19. Red Lake Electric Coop, Inc | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Red Lake Electric Coop, Inc Jump to: navigation, search Name: Red Lake Electric Coop, Inc Place: Minnesota Phone Number: 218-253-2168 or 800-245-6068 Website: www.redlakeelectric.c...

  20. City of Wall Lake, Iowa (Utility Company) | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    City of Wall Lake, Iowa (Utility Company) Jump to: navigation, search Name: City of Wall Lake Place: Iowa Phone Number: (712) 664-2216 Website: walllake.com?pageid40 Outage...

  1. Cooperative L&P Assn Lake Cnty | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Cooperative L&P Assn Lake Cnty Jump to: navigation, search Name: Cooperative L&P Assn Lake Cnty Place: Minnesota Phone Number: 800-580-5881 Website: www.clpower.com Facebook:...

  2. Montana Joint Application for Proposed Work in Streams, Lakes...

    OpenEI (Open Energy Information) [EERE & EIA]

    Streams, Lakes and Wetlands Webpage Jump to: navigation, search OpenEI Reference LibraryAdd to library Web Site: Montana Joint Application for Proposed Work in Streams, Lakes and...

  3. Overexpression of miR-206 suppresses glycolysis, proliferation and migration in breast cancer cells via PFKFB3 targeting

    SciTech Connect

    Ge, Xin; Lyu, Pengwei; Cao, Zhang; Li, Jingruo; Guo, Guangcheng; Xia, Wanjun; Gu, Yuanting

    2015-08-07

    miRNAs, sorting as non-coding RNAs, are differentially expressed in breast tumor and act as tumor promoters or suppressors. miR-206 could suppress the progression of breast cancer, the mechanism of which remains unclear. The study here was aimed to investigate the effect of miR-206 on human breast cancers. We found that miR-206 was down-regulated while one of its predicted targets, 6-Phosphofructo-2-kinase (PFKFB3) was up-regulated in human breast carcinomas. 17β-estradiol dose-dependently decreased miR-206 expression as well as enhanced PFKFB3 mRNA and protein expression in estrogen receptor α (ERα) positive breast cancer cells. Furthermore, we identified that miR-206 directly interacted with 3′-untranslated region (UTR) of PFKFB3 mRNA. miR-206 modulated PFKFB3 expression in MCF-7, T47D and SUM159 cells, which was influenced by 17β-estradiol depending on ERα expression. In addition, miR-206 overexpression impeded fructose-2,6-bisphosphate (F2,6BP) production, diminished lactate generation and reduced cell proliferation and migration in breast cancer cells. In conclusion, our study demonstrated that miR-206 regulated PFKFB3 expression in breast cancer cells, thereby stunting glycolysis, cell proliferation and migration. - Highlights: • miR-206 was down-regulated and PFKFB3 was up-regulated in human breast carcinomas. • 17β-estradiol regulated miR-206 and PFKFB3 expression in ERα+ cancer cells. • miR-206directly interacted with 3′-UTR of PFKFB3 mRNA. • miR-206 fructose-2,6-bisphosphate (F2,6BP) impeded production and lactate generation. • miR-206 reduced cell proliferation and migration in breast cancer cells.

  4. Lake Roosevelt Fisheries Evaluation Program; Meadow Creek vs. Lake Whatcom Stock Kokanee Salmon Investigations in Lake Roosevelt, 2001 Annual Report.

    SciTech Connect

    McLellan, Holly; Scholz, Allan

    2002-03-01

    Lake Roosevelt has been stocked with Lake Whatcom stock kokanee since 1989 with the primary objective of creating a self-sustaining recreational fishery. Due to low return numbers, it was hypothesized a stock of kokanee, native to the upper Columbia River, might perform better than the coastal Lake Whatcom strain. Kokanee from Meadow Creek, a tributary of Kootenay Lake, British Columbia were selected as an alternative stock. Matched pair releases of Lake Whatcom and Meadow Creek kokanee were made from Sherman Creek Hatchery in late June 2000 and repeated in 2001. Stock performance between Lake Whatcom and Meadow Creek kokanee was evaluated using three performance measures; (1) the number of returns to Sherman Creek, the primary egg collection facility, (2) the number of returns to other tributaries and (3) the number of returns to the creel. Kokanee were collected during five passes through the reservoir via electrofishing, which included 87 tributary mouths during the fall of 2000 and 2001. Chi-square analysis indicated age two Meadow Creek kokanee returned to Sherman Creek in significantly higher numbers when compared to the Whatcom stock in 2000 ({chi}{sup 2} = 736.6; d.f. = 1; P < 0.01) and 2001 ({chi}{sup 2} = 156.2; d.f. = 1; P < 0.01). Reservoir wide recoveries of age two kokanee had similar results in 2000 ({chi}{sup 2} = 735.3; d.f. = 1; P < 0.01) and 2001 ({chi}{sup 2} = 150.1; d.f. = 1; P < 0.01). Six Lake Whatcom and seven Meadow Creek three year olds were collected in 2001. The sample size of three year olds was too small for statistical analysis. No kokanee were collected during creel surveys in 2000, and two (age three kokanee) were collected in 2001. Neither of the hatchery kokanee collected were coded wire tagged, therefore stock could not be distinguished. After two years of monitoring, neither Meadow Creek or Lake Whatcom kokanee appear to be capable of providing a run of three-year-old spawners to sustain stocking efforts. The small number of

  5. Lake Roosevelt Fisheries Evaluation Program; Meadow Creek vs. Lake Whatcom Stock Kokanee Salmon Investigations in Lake Roosevelt, Annual Report 2002.

    SciTech Connect

    McLellan, Holly

    2003-03-01

    Lake Whatcom, Washington kokanee have been stocked in Lake Roosevelt since 1987 with the primary objective of creating a self-sustaining fishery. Success has been limited by low recruitment to the fishery, low adult returns to hatcheries, and a skewed sex ratio. It was hypothesized that a stock native to the upper Columbia River might perform better than the coastal Lake Whatcom stock. Kokanee from Meadow Creek, a tributary of Kootenay Lake, British Columbia were selected as an alternative stock. Post smolts from each stock were released from Sherman Creek Hatchery in late June 2000 and repeated in 2001. Stock performance was evaluated using three measures; (1) number of returns to Sherman Creek, the primary egg collection facility, (2) the number of returns to 86 tributaries sampled and, (3) the number of returns to the creel. In two repeated experiments, neither Meadow Creek or Lake Whatcom kokanee appeared to be capable of providing a run of three-year old spawners to sustain stocking efforts. Less than 10 three-years olds from either stock were collected during the study period. Chi-square analysis indicated age two Meadow Creek kokanee returned to Sherman Creek and to other tributaries in significantly higher numbers when compared to the Lake Whatcom stock in both 2000 and 2001. However, preliminary data from the Spokane Tribe of Indians indicated that a large number of both stocks were precocial before they were stocked. The small number of hatchery three-year olds collected indicated that the current hatchery rearing and stocking methods will continue to produce a limited jacking run largely composed of precocious males and a small number of three-year olds. No kokanee from the study were collected during standard lake wide creel surveys. Supplemental creel data, including fishing derbies, test fisheries, and angler diaries, indicated anglers harvested two-year-old hatchery kokanee a month after release. The majority of the two-year old kokanee harvested

  6. Trends in polycyclic aromatic hydrocarbon concentrations in the Great Lakes atmosphere

    SciTech Connect

    Ping Sun; Pierrette Blanchard; Kenneth A. Brice; Ronald A. Hites

    2006-10-15

    Atmospheric polycyclic aromatic hydrocarbon (PAHs) concentrations were measured in both the vapor and particle phases at seven sites near the Great Lakes as a part of the Integrated Atmospheric Deposition Network. Lower molecular weight PAHs, including fluorene, phenanthrene, fluoranthrene, and pyrene, were dominant in the vapor phase, and higher molecular weight PAHs, including chrysene, benzo(a)pyrene, and coronene, were dominant in the particle phase. The highest PAH concentrations in both the vapor and particle phases were observed in Chicago followed by the semiurban site at Sturgeon Point, NY. The major sources of PAHs in and around Chicago are vehicle emissions, coal and natural gas combustion, and coke production. The spatial difference of PAH concentrations can be explained by the local population density. Long-term decreasing trends of most PAH concentrations were observed in both the vapor and particle phases at Chicago, with half-lives ranging from 3-10 years in the vapor phase and 5-15 years in the particle phase. At Eagle Harbor, Sleeping Bear Dunes, and Sturgeon Point, total PAH concentrations in the vapor phase showed significant, but slow, long-term decreasing trends. At the Sturgeon Point site, which was impacted by a nearby city, particle-phase PAH concentrations also declined. However, most particle-phase PAH concentrations did not show significant long-term decreasing trends at the remote sites. Seasonal trends were also observed for particle-phase PAH concentrations, which were higher in the winter and lower in the summer. 36 refs., 4 figs., 1 tab.

  7. Great Lakes Water Scarcity and Regional Economic Development

    ScienceCinema

    Cameron Davis; Tim Eder; David Ulrich; David Naftzger; Donald J. Wuebbles; Mark C. Petri

    2016-07-12

    Great Lakes Water Scarcity and Regional Economic Development panel at Northwestern University on 10/10/2012

  8. Great Lakes Water Scarcity and Regional Economic Development

    SciTech Connect

    Cameron Davis; Tim Eder; David Ulrich; David Naftzger; Donald J. Wuebbles; Mark C. Petri

    2012-10-10

    Great Lakes Water Scarcity and Regional Economic Development panel at Northwestern University on 10/10/2012

  9. NBP RFI: Communications Requirements- Comments of Lake Region Electric

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Cooperative- Minnesota | Department of Energy Lake Region Electric Cooperative- Minnesota NBP RFI: Communications Requirements- Comments of Lake Region Electric Cooperative- Minnesota Comments of Lake Region Electric Cooperative- Minnesota on Implementing the National Broadband Plan by Studying the Communications Requirements of Electric Utilities to Inform Federal Smart Grid Policy NBP RFI: Communications Requirements- Comments of Lake Region Electric Cooperative- Minnesota (133.57 KB) More

  10. PROJECT PROFILE: Salt Lake City Corporation (Solar Market Pathways) |

    Energy Saver

    Department of Energy Salt Lake City Corporation (Solar Market Pathways) PROJECT PROFILE: Salt Lake City Corporation (Solar Market Pathways) Title: Wasatch Solar Project WASATCH solar logo.png Funding Opportunity: Solar Market Pathways SunShot Subprogram: Soft Costs Location: Salt Lake City, UT Amount Awarded: $600,000 Awardee Cost Share: $164,645 Salt Lake City and its partners are developing a comprehensive long-term solar deployment strategy, which includes an analysis of the value of

  11. Geothermal Literature Review At Medicine Lake Geothermal Area...

    OpenEI (Open Energy Information) [EERE & EIA]

    navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Geothermal Literature Review At Medicine Lake Geothermal Area (1984) Exploration Activity Details Location...

  12. AMENDMENT OF SOLICITATION/MODIFICATlON OF CONTRACT MI54 I See...

    National Nuclear Security Administration (NNSA)

    MI54 I See Block 16C I REQ. NO. Babcock & Wilcox Technical Services Pantex, LLC PO Box 30020 Amarillo, TX 79120 2. AMENDMENTIMODIFICATION NO. 1 3. EFFECTIVE DATE 1 4. ...

  13. File:USDA-CE-Production-GIFmaps-MI.pdf | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    MI.pdf Jump to: navigation, search File File history File usage Michigan Ethanol Plant Locations Size of this preview: 463 599 pixels. Other resolution: 464 600 pixels. Full...

  14. Silica Extraction at Mammoth Lakes, California

    SciTech Connect

    Bourcier, W; Ralph, W; Johnson, M; Bruton, C; Gutierrez, P

    2006-06-07

    The purpose of this project is to develop a cost-effective method to extract marketable silica (SiO{sub 2}) from fluids at the Mammoth Lakes, California geothermal power plant. Silica provides an additional revenue source for the geothermal power industry and therefore lowers the costs of geothermal power production. The use of this type of ''solution mining'' to extract resources eliminates the need for acquiring these resources through energy intensive and environmentally damaging mining technologies. We have demonstrated that both precipitated and colloidal silica can be produced from the geothermal fluids at Mammoth Lakes by first concentrating the silica to over 600 ppm using reverse osmosis (RO). The RO permeate can be used in evaporative cooling at the plant; the RO concentrate is used for silica and potentially other resource extraction (Li, Cs, Rb). Preliminary results suggest that silica recovery at Mammoth Lakes could reduce the cost of geothermal electricity production by 1.0 cents/kWh.

  15. Simulations of neutron multiplicity measurements with MCNP-PoliMi.

    SciTech Connect

    Mattingly, John K.; Pozzi, Sara A.; Clarke, Shaun D.; Dennis, Ben D.; Miller, Eric C.

    2010-09-01

    The heightened focus on nuclear safeguards and accountability has increased the need to develop and verify simulation tools for modeling these applications. The ability to accurately simulate safeguards techniques, such as neutron multiplicity counting, aids in the design and development of future systems. This work focuses on validating the ability of the Monte Carlo code MCNPX-PoliMi to reproduce measured neutron multiplicity results for a highly multiplicative sample. The benchmark experiment for this validation consists of a 4.5-kg sphere of plutonium metal that was moderated by various thicknesses of polyethylene. The detector system was the nPod, which contains a bank of 15 3He detectors. Simulations of the experiments were compared to the actual measurements and several sources of potential bias in the simulation were evaluated. The analysis included the effects of detector dead time, source-detector distance, density, and adjustments made to the value of {nu}-bar in the data libraries. Based on this analysis it was observed that a 1.14% decrease in the evaluated value of {nu}-bar for 239Pu in the ENDF-VII library substantially improved the accuracy of the simulation.

  16. L-Lake fish: L-Lake/Steel Creek Biological Monitoring Program, January 1986--December 1991

    SciTech Connect

    Sayers, R.E. Jr.; Mealing, H.G. III

    1992-04-01

    The L Lake Biological Monitoring Program was designed to meet environmental regulatory requirements associated with the re-start of L-Reactor and address portions of Section 316(a) of the Clean Water Act, which requires an applicant for a discharge permit to provide scientific evidence that the discharge causes no significant impact on the indigenous ecosystem. The Department of Energy (DOE) must demonstrate that the discharge of L-Reactor effluent into L Lake will not inhibit the eventual establishment of a ``Balanced Biological Community`` (BBC) in at least 50% of the lake.

  17. Climate Action Champions: Sault Ste. Marie Tribe of Chippewa Indians, MI |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Sault Ste. Marie Tribe of Chippewa Indians, MI Climate Action Champions: Sault Ste. Marie Tribe of Chippewa Indians, MI The Sault Ste. Marie Tribe of Chippewa Indians is a 44,000-strong federally recognized Indian tribe that is an economic, social and cultural force in its community across the eastern Upper Peninsula counties of Chippewa, Luce, Mackinac, Schoolcraft, Alger, Delta and Marquette, with housing and tribal centers, casinos, and other enterprises that employ

  18. Climate Action Champions: Salt Lake City, UT | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Salt Lake City, UT Climate Action Champions: Salt Lake City, UT Salt Lake City, the capital of Utah, blends snowy mountain ranges with an urban downtown. Known historically as the “Crossroads of the West,” Salt Lake City today is a major economic center in the Great Basin and a hub of tourism. │ Photo courtesy of University of Utah Department of Mathematics. Salt Lake City, the capital of Utah, blends snowy mountain ranges with an urban downtown. Known historically as the

  19. U.S. Total Exports

    Energy Information Administration (EIA) (indexed site)

    Total To Barbados Total To Brazil Freeport, TX Sabine Pass, LA Total to Canada Eastport, ID Calais, ME Detroit, MI Marysville, MI Port Huron, MI Crosby, ND Portal, ND Sault St. Marie, MI St. Clair, MI Noyes, MN Warroad, MN Babb, MT Havre, MT Port of Morgan, MT Sherwood, ND Pittsburg, NH Buffalo, NY Grand Island, NY Massena, NY Niagara Falls, NY Waddington, NY Sumas, WA Sweetgrass, MT Total to Chile Sabine Pass, LA Total to China Kenai, AK Sabine Pass, LA Total to Egypt Freeport, TX Total to

  20. Salt Lake City | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    Salt Lake City Gamma Shield Thunder Exercise Concludes National Nuclear Security Administration (NNSA) and the FBI announced today the completion of the Gamma Shield Thunder counterterrorism table-top exercise at LDS Hospital. The exercise is part of NNSA's Silent Thunder table-top series, which is aimed at giving federal, state and local

  1. miR-196a targets netrin 4 and regulates cell proliferation and migration of cervical cancer cells

    SciTech Connect

    Zhang, Jie; Zheng, Fangxia; Yu, Gang; Yin, Yanhua; Lu, Qingyang

    2013-11-01

    Highlights: miR-196a was overexpressed in cervical cancer tissue compared to normal tissue. miR-196a expression elevated proliferation and migration of cervical cancer cells. miR-196a inhibited NTN4 expression by binding 3?-UTR region of NTN4 mRNA. NTN4 inversely correlated with miR-196a expression in cervical tissue and cell line. NTN4 expression was low in cervical cancer tissue compared to normal tissue. -- Abstract: Recent research has uncovered tumor-suppressive and oncogenic potential of miR-196a in various tumors. However, the expression and mechanism of its function in cervical cancer remains unclear. In this study, we assess relative expression of miR-196a in cervical premalignant lesions, cervical cancer tissues, and four cancer cell lines using quantitative real-time PCR. CaSki and HeLa cells were treated with miR-196a inhibitors, mimics, or pCDNA/miR-196a to investigate the role of miR-196a in cancer cell proliferation and migration. We demonstrated that miR-196a was overexpressed in cervical intraepithelial neoplasia 23 and cervical cancer tissue. Moreover, its expression contributes to the proliferation and migration of cervical cancer cells, whereas inhibiting its expression led to a reduction in proliferation and migration. Five candidate targets of miR-196a chosen by computational prediction and Cervical Cancer Gene Database search were measured for their mRNA in both miR-196a-overexpressing and -depleted cancer cells. Only netrin 4 (NTN4) expression displayed an inverse association with miR-196a. Fluorescent reporter assays revealed that miR-196a inhibited NTN4 expression by targeting one binding site in the 3?-untranslated region (3?-UTR) of NTN4 mRNA. Furthermore, qPCR and Western blot assays verified NTN4 expression was downregulated in cervical cancer tissues compared to normal controls, and in vivo mRNA level of NTN4 inversely correlated with miR-196a expression. In summary, our findings provide new insights about the functional role of

  2. Oncorhynchus nerka population monitoring in the Sawtooth Valley Lakes

    SciTech Connect

    Teuscher, D.M.; Taki, D.; Ariwite, K.

    1996-05-01

    Critical habitat for endangered Snake River sockeye salmon includes five rearing lakes located in the Sawtooth Valley of central Idaho. Most of the lakes contain either introduced or endemic kokanee populations. Snake River sockeye occur naturally in Redfish Lake, and are being stocked in Redfish and Pettit Lakes. Because kokanee compete with sockeye for limited food resources, understanding population characteristics of both species such as spawn timing, egg-to-fry survival, distribution and abundance are important components of sockeye recovery. This chapter describes some of those characteristics. In 1995, hydroacoustic estimates of O. nerka densities in the Sawtooth Valley Lakes ranged from 57 to 465 fish/ha. Densities were greatest in Pettit followed by Redfish (167), Alturas (95), and Stanley Lakes. O. nerka numbers increased from 1994 values in Pettit and Alturas Lakes, but declined in Redfish and Stanley. Despite a decline in total lake abundance, O. nerka biomass estimates in Redfish Lake increased. Approximately 144,000 kokanee fry recruited to Redfish Lake from Fishhook Creek. O. nerka fry recruitment to Stanley and Alturas lake was 5,000 and 30,000 fry, respectively. Egg-to-fry survival was 14% in Fishhook and 7% in Stanley Lake Creek. In Fishhook Creek, kokanee spawning escapement was estimated using stream surveys and a weir. Escapement estimates were 4,860 from weir counts, and 7,000 from stream surveys. As part of the kokanee reduction program, 385 of the spawning female kokanee were culled. Escapement for Stanley Lake Creek was only 60 fish, a ten fold decrease from 1994. In Alturas Lake, kokanee spawners dropped by 50% to 1,600.

  3. CANTON LAKESHORE CANTON E BEST CON NEAUT GIDD INGS EAST N ELLSWORT

    Energy Information Administration (EIA) (indexed site)

    Liquids Reserve Class No 2001 liquids reserves 0.1 - 10 Mbbl 10.1 - 100 Mbbl 100.1 - 1,000 Mbbl 1,000.1 - 10,000 Mbbl Appalachian Basin Boundary C a n a d a U S A OH PA MI NY Lake Erie Lake St. Claire Total Total Total Number Liquid Gas BOE of Reserves Reserves Reserves Basin Fields (Mbbl) (MMcf) (Mbbl) Appalachian 3354 79,141 9,550,156 1,670,834 2001 Proved Reserves for Entire Applachian Basin WV Appalachian Basin, OH-PA (Panel 2 of 7) Oil and Gas Fields By 2001 Liquids

  4. Source characterization and control technology assessment of methylene chloride emissions from Eastman Kodak Company, Rochester, NY. Final report, July 1988-April 1989

    SciTech Connect

    Walata, S.A.; Rehm, R.M.

    1989-07-01

    This report gives results of an assessment of potential control technologies for methylene chloride (also known as dichloromethane or DCM) emission sources at Eastman Kodak Company's Kodak Park facility in Rochester, NY. DCM is a solvent used by Kodak in the manufacture of cellulose triacetate film support. Work has involved: a plant visit where major DCM emission sources were inspected, and evaluation of current and potential control technologies for the DCM emission sources. The report contains information gathered during the plant visit to the Kodak Park facility. Included are emission estimates determined by Kodak of all emission points greater than 8000 lb (3600 kg)/yr DCM, as well as a description of each point observed during the visit. Also included are results of an evaluation of control technologies that might be applied to the major emission sources. A cost analysis of different add-on control devices is provided for four of the uncontrolled emission points.

  5. Lake Michigan Offshore Wind Feasibility Assessment

    SciTech Connect

    Boezaart, Arnold; Edmonson, James; Standridge, Charles; Pervez, Nahid; Desai, Neel; Williams, Bruce; Clark, Aaron; Zeitler, David; Kendall, Scott; Biddanda, Bopi; Steinman, Alan; Klatt, Brian; Gehring, J. L.; Walter, K.; Nordman, Erik E.

    2014-06-30

    The purpose of this project was to conduct the first comprehensive offshore wind assessment over Lake Michigan and to advance the body of knowledge needed to support future commercial wind energy development on the Great Lakes. The project involved evaluation and selection of emerging wind measurement technology and the permitting, installation and operation of the first mid-lake wind assessment meteorological (MET) facilities in Michigan’s Great Lakes. In addition, the project provided the first opportunity to deploy and field test floating LIDAR and Laser Wind Sensor (LWS) technology, and important research related equipment key to the sitting and permitting of future offshore wind energy development in accordance with public participation guidelines established by the Michigan Great Lakes Wind Council (GLOW). The project created opportunities for public dialogue and community education about offshore wind resource management and continued the dialogue to foster Great Lake wind resource utilization consistent with the focus of the GLOW Council. The technology proved to be effective, affordable, mobile, and the methods of data measurement accurate. The public benefited from a substantial increase in knowledge of the wind resources over Lake Michigan and gained insights about the potential environmental impacts of offshore wind turbine placements in the future. The unique first ever hub height wind resource assessment using LWS technology over water and development of related research data along with the permitting, sitting, and deployment of the WindSentinel MET buoy has captured public attention and has helped to increase awareness of the potential of future offshore wind energy development on the Great Lakes. Specifically, this project supported the acquisition and operation of a WindSentinel (WS) MET wind assessment buoy, and associated research for 549 days over multiple years at three locations on Lake Michigan. Four research objectives were defined for the

  6. <mi>B> -meson decay constants from 2+1 -flavor lattice QCD with domain-wall light quarks and relativistic heavy quarks

    SciTech Connect

    Christ, N. H.; Flynn, J. M.; Izubuchi, T.; Kawanai, T.; Lehner, C.; Soni, A.; Van de Water, R. S.; Witzel, O.

    2015-03-01

    We calculate the mi>Bmi>-meson decay constants mi>fmi>mi>Bmi>, mi>fmi>mi>Bmi>mi>smi>, and their ratio in unquenched lattice QCD using domain-wall light quarks and relativistic mi>b> quarks. We use gauge-field ensembles generated by the RBC and UKQCD collaborations using the domain-wall fermion action and Iwasaki gauge action with three flavors of light dynamical quarks. We analyze data at two lattice spacings of mi>ami>0.11, 0.086 fm with unitary pion masses as light as mi>Mmi>mi>πmi>290mi>MeV>; this enables us to control the extrapolation to the physical light-quark masses and continuum. For the mi>b> quarks we use the anisotropic clover action with the relativistic heavy-quark interpretation, such that discretization errors from the heavy-quark action are of the same size as from the light-quark sector. We renormalize the

  7. miR-214 promotes the proliferation and invasion of osteosarcoma cells through direct suppression of LZTS1

    SciTech Connect

    Xu, Zhengyu; Wang, Tao

    2014-06-27

    Highlights: • miR-214 is upregulated in human OS tissues and inversely correlated with LZTS1 expression. • miR-214 directly targets LZTS1 by binding to its 3′-UTR. • miR-214 promotes OS cell proliferation, invasion and tumor growth. • Overexpression of LZTS1 reverses miR-214-induced proliferation and invasion of OS cells. - Abstract: Previous studies have shown that miR-214 functions either as an oncogene or a tumor suppressor in various human cancer types. The role of this microRNA in osteosarcoma (OS) is presently unclear. Here, we demonstrated that miR-214 is frequently upregulated in OS specimens, compared with noncancerous bone tissues. Bioinformatics analysis further revealed leucine zipper, putative tumor suppressor 1 (LZTS1) as a potential target of miR-214. Expression patterns of miR-214 were inversely correlated with those of LZTS1 mRNA and protein in OS tissues. Data from reporter assays showed that miR-214 directly binds to the 3′-untranslated region (3′-UTR) of LZTS1 mRNA and suppresses expression at both transcriptional and translational levels. In functional assays, miR-214 promoted OS cell proliferation, invasion and tumor growth in nude mice, which could be reversed by overexpression of LZTS1. Taken together, our data provide compelling evidence that miR-214 functions as an onco-miRNA in OS, and its oncogenic effects are mediated chiefly through downregulation of LZTS1.

  8. MiR-132 prohibits proliferation, invasion, migration, and metastasis in breast cancer by targeting HN1

    SciTech Connect

    Zhang, Zhan-Guo Chen, Wei-Xun Wu, Yan-Hui Liang, Hui-Fang Zhang, Bi-Xiang

    2014-11-07

    Highlights: • MiR-132 is down-regulated in breast cancer tissues and cell lines. • MiR-132 directly regulates HN1 by binding its 3′ UTR. • MiR-132 shows regulatory role in proliferation, invasion, migration and metastasis. • HN1 is involved in miR-132-mediated cell behavior. • Aberrant HN1 is associated with worse overall survival of breast cancer patients. - Abstract: Accumulating evidence indicates that miRNAs play critical roles in tumorigenesis and cancer progression. This study aims to investigate the role and the underlying mechanism of miR-132 in breast cancer. Here, we report that miR-132 is significantly down-regulated in breast cancer tissues and cancer cell lines. Additional study identifies HN1 as a novel direct target of miR-132. MiR-132 down-regulates HN1 expression by binding to the 3′ UTR of HN1 transcript, thereby, suppressing multiple oncogenic traits such as cancer cell proliferation, invasion, migration and metastasis in vivo and in vitro. Overexpression of HN1 restores miR-132-suppressed malignancy. Importantly, higher HN1 expression is significantly associated with worse overall survival of breast cancer patients. Taken together, our data demonstrate a critical role of miR-132 in prohibiting cell proliferation, invasion, migration and metastasis in breast cancer through direct suppression of HN1, supporting the potential utility of miR-132 as a novel therapeutic strategy against breast cancer.

  9. miR-421 induces cell proliferation and apoptosis resistance in human nasopharyngeal carcinoma via downregulation of FOXO4

    SciTech Connect

    Chen, Liang; Department of Otolaryngology, Guangzhou General Hospital of PLA Guangzhou Command, Guangzhou 510010 ; Tang, Yanping; Wang, Jian; Yan, Zhongjie; Xu, Ruxiang

    2013-06-14

    Highlights: •miR-421 is upregulated in nasopharyngeal carcinoma. •miR-421 induces cell proliferation and apoptosis resistance. •FOXO4 is a direct and functional target of miR-421. -- Abstract: microRNAs have been demonstrated to play important roles in cancer development and progression. Hence, identifying functional microRNAs and better understanding of the underlying molecular mechanisms would provide new clues for the development of targeted cancer therapies. Herein, we reported that a microRNA, miR-421 played an oncogenic role in nasopharyngeal carcinoma. Upregulation of miR-421 induced, whereas inhibition of miR-421 repressed cell proliferation and apoptosis resistance. Furthermore, we found that upregulation of miR-421 inhibited forkhead box protein O4 (FOXO4) signaling pathway following downregulation of p21, p27, Bim and FASL expression by directly targeting FOXO4 3′UTR. Additionally, we demonstrated that FOXO4 expression is critical for miR-421-induced cell growth and apoptosis resistance. Taken together, our findings not only suggest that miR-421 promotes nasopharyngeal carcinoma cell proliferation and anti-apoptosis, but also uncover a novel regulatory mechanism for inactivation of FOXO4 in nasopharyngeal carcinoma.

  10. Roles of miRNAs in microcystin-LR-induced Sertoli cell toxicity

    SciTech Connect

    Zhou, Yuan; Wang, Hui; Wang, Cong; Qiu, Xuefeng; Benson, Mikael; Yin, Xiaoqin; Xiang, Zou; Li, Dongmei; and others

    2015-08-15

    Microcystin (MC)-LR, a cyclic heptapeptide, is a potent reproductive system toxin. To understand the molecular mechanisms of MC-induced reproductive system cytotoxicity, we evaluated global changes of miRNA and mRNA expression in mouse Sertoli cells following MC-LR treatment. Our results revealed that the exposure to MC-LR resulted in an altered miRNA expression profile that might be responsible for the modulation of mRNA expression. Bio-functional analysis indicated that the altered genes were involved in specific cellular processes, including cell death and proliferation. Target gene analysis suggested that junction injury in Sertoli cells exposed to MC-LR might be mediated by miRNAs through the regulation of the Sertoli cell-Sertoli cell pathway. Collectively, these findings may enhance our understanding on the modes of action of MC-LR on mouse Sertoli cells as well as the molecular mechanisms underlying the toxicity of MC-LR on the male reproductive system. - Highlights: • miRNAs were altered in Sertoli cells exposed to MC-LR. • Alerted genes were involved in different cell functions including the cell morphology. • MC-LR adversely affected Sertoli cell junction formation through the regulating miRNAs.

  11. Long-term elemental dry deposition fluxes measured around Lake Michigan with an automated dry deposition sampler

    SciTech Connect

    Shahin, U. Yi, S.M.; Paode, R.D.; Holsen, T.M.

    2000-05-15

    Long-term measurements of mass and elemental dry deposition (MG, Al, V, Cr, Mn, Ni, Co, Cu, Zn, As, Sr, Mo, Cd, Sb, Ba, and Pb) were made with an automated dry deposition sampler (Eagle II) containing knife-edge surrogate surfaces during the Lake Michigan Mass Balance/Mass Budget Study. Measurements were made over a roughly 700-day period in Chicago, IL; in South Haven and Sleeping Bear Dunes, MI; and over Lake Michigan on the 68th Street drinking water intake cribs from December 1993 to October 1995. Average mass fluxes in Chicago, South Haven, Sleeping Bear Dunes, and the 68th Street crib were 65, 10, 3.6, and 12 mg m{sup {minus}2} day{sup {minus}1}, respectively. Primarily crustal elemental fluxes were significantly smaller than the mass fluxes but higher than primarily anthropogenic elemental fluxes. For example, the average elemental flux of Al in Chicago, South Haven, Sleeping Bear Dunes, and the 68th Street crib were 1.0, 0.34, 0.074, and 0.34 mg m{sup {minus}2}day{sup {minus}1}, respectively. The average Pb fluxes in Chicago, South Haven, Sleeping Bear Dunes, and the 68th Street crib were 0.038, 0.023, 0.035, and 0.032 mg m{sup {minus}2}day{sup {minus}1}, respectively. The measured fluxes at the various sites were used to calculate the dry deposition loadings to the lake. These estimated fluxes were highest for Mg and lowest for Cd.

  12. Ionizing Radiation–Inducible miR-27b Suppresses Leukemia Proliferation via Targeting Cyclin A2

    SciTech Connect

    Wang, Bo; Li, Dongping; Kovalchuk, Anna; Litvinov, Dmitry; Kovalchuk, Olga

    2014-09-01

    Purpose: Ionizing radiation is a common carcinogen that is important for the development of leukemia. However, the underlying epigenetic mechanisms remain largely unknown. The goal of the study was to explore microRNAome alterations induced by ionizing radiation (IR) in murine thymus, and to determine the role of IR-inducible microRNA (miRNA/miR) in the development of leukemia. Methods and Materials: We used the well-established C57BL/6 mouse model and miRNA microarray profiling to identify miRNAs that are differentially expressed in murine thymus in response to irradiation. TIB152 human leukemia cell line was used to determine the role of estrogen receptor–α (ERα) in miR-27b transcription. The biological effects of ectopic miR-27b on leukemogenesis were measured by western immunoblotting, cell viability, apoptosis, and cell cycle analyses. Results: Here, we have shown that IR triggers the differential expression of miR-27b in murine thymus tissue in a dose-, time- and sex-dependent manner. miR-27b was significantly down-regulated in leukemia cell lines CCL119 and TIB152. Interestingly, ERα was overexpressed in those 2 cell lines, and it was inversely correlated with miR-27b expression. Therefore, we used TIB152 as a model system to determine the role of ERα in miR-27b expression and the contribution of miR-27b to leukemogenesis. β-Estradiol caused a rapid and transient reduction in miR-27b expression reversed by either ERα-neutralizing antibody or ERK1/2 inhibitor. Ectopic expression of miR-27b remarkably suppressed TIB152 cell proliferation, at least in part, by inducing S-phase arrest. In addition, it attenuated the expression of cyclin A2, although it had no effect on the levels of PCNA, PPARγ, CDK2, p21, p27, p-p53, and cleaved caspase-3. Conclusion: Our data reveal that β-estradiol/ERα signaling may contribute to the down-regulation of miR-27b in acute leukemia cell lines through the ERK1/2 pathway, and that miR-27b may function as a tumor

  13. Curcumin inhibits oral squamous cell carcinoma SCC-9 cells proliferation by regulating miR-9 expression

    SciTech Connect

    Xiao, Can; Wang, Lili; Zhu, Lifang; Zhang, Chenping; Zhou, Jianhua

    2014-11-28

    Highlights: • miR-9 expression level was significantly decreased in OSCC tissues. • Curcumin significantly inhibited SCC-9 cells proliferation. • miR-9 mediates the inhibition of SCC-9 proliferation by curcumin. • Curcumin suppresses Wnt/β-catenin signaling in SCC-9 cells. • miR-9 mediates the suppression of Wnt/β-catenin signaling by curcumin. - Abstract: Curcumin, a phytochemical derived from the rhizome of Curcuma longa, has shown anticancer effects against a variety of tumors. In the present study, we investigated the effects of curcumin on the miR-9 expression in oral squamous cell carcinoma (OSCC) and explored the potential relationships between miR-9 and Wnt/β-catenin pathway in curcumin-mediated OSCC inhibition in vitro. As the results shown, the expression levels of miR-9 were significantly lower in clinical OSCC specimens than those in the adjacent non-tumor tissues. Furthermore, our results indicated that curcumin inhibited OSCC cells (SCC-9 cells) proliferation through up-regulating miR-9 expression, and suppressing Wnt/β-catenin signaling by increasing the expression levels of the GSK-3β, phosphorylated GSK-3β and β-catenin, and decreasing the cyclin D1 level. Additionally, the up-regulation of miR-9 by curcumin in SCC-9 cells was significantly inhibited by delivering anti-miR-9 but not control oligonucleotides. Downregulation of miR-9 by anti-miR-9 not only attenuated the growth-suppressive effects of curcumin on SCC-9 cells, but also re-activated Wnt/β-catenin signaling that was inhibited by curcumin. Therefore, our findings would provide a new insight into the use of curcumin against OSCC in future.

  14. miR-339-5p inhibits alcohol-induced brain inflammation through regulating NF-κB pathway

    SciTech Connect

    Zhang, Yu; Wei, Guangkuan; Di, Zhiyong; Zhao, Qingjie

    2014-09-26

    Graphical abstract: - Highlights: • Alcohol upregulates miR-339-5p expression. • miR-339-5p inhibits the NF-kB pathway. • miR-339-5p interacts with and blocks activity of IKK-beat and IKK-epsilon. • miR-339-5p modulates IL-1β, IL-6 and TNF-α. - Abstract: Alcohol-induced neuroinflammation is mediated by the innate immunesystem. Pro-inflammatory responses to alcohol are modulated by miRNAs. The miRNA miR-339-5p has previously been found to be upregulated in alcohol-induced neuroinflammation. However, little has been elucidated on the regulatory functions of this miRNA in alcohol-induced neuroinflammation. We investigated the function of miR-339-5p in alcohol exposed brain tissue and isolated microglial cells using ex vivo and in vitro techniques. Our results show that alcohol induces transcription of miR 339-5p, IL-6, IL-1β and TNF-α in mouse brain tissue and isolated microglial cells by activating NF-κB. Alcohol activation of NF-κB allows for nuclear translocation of the NF-κB subunit p65 and expression of pro-inflammatory mediators. miR-339-5p inhibited expression of these pro-inflammatory factors through the NF-κB pathway by abolishing IKK-β and IKK-ε activity.

  15. miR-208-3p promotes hepatocellular carcinoma cell proliferation and invasion through regulating ARID2 expression

    SciTech Connect

    Yu, Peng; Wu, Dingguo; You, Yu; Sun, Jing; Lu, Lele; Tan, Jiaxing; Bie, Ping

    2015-08-15

    MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at post-transcriptional level. miRNA dysregulation plays a causal role in cancer progression. In this study, miR-208-3p was highly expressed and directly repressed ARID2 expression. As a result, ARID2 expression in hepatocellular carcinoma (HCC) was decreased. In vitro, miR-208-3p down-regulation and ARID2 over-expression elicited similar inhibitory effects on HCC cell proliferation and invasion. In vivo test results revealed that miR-208-3p down-regulation inhibited HCC tumorigenesis in Hep3B cells. Moreover, ARID2 was possibly a downstream element of transforming growth factor beta1 (TGFβ1)/miR-208-3p/ARID2 regulatory pathway. These findings suggested that miR-208-3p up-regulation is associated with HCC cell progression and may provide a new target for liver cancer treatment. - Highlights: • miR-208-3p was highly expressed and directly repressed the expression of ARID2 in HCC. • miR-208-3p contributed to HCC cell progression both in vitro and in vivo. • Over-expression of ARID2 inhibited the HCC cell proliferation and invasion. • Restoration of ARID2 partly reversed the the effect of miR-208-3p down-regulation on HCC cells. • Newly regulatory pathway: miR-208-3p mediated the repression of ARID2 by TGFβ1 in HCC cells.

  16. EA-2019: Lake Erie Connector Project

    Energy.gov [DOE]

    DOE is preparing an EA that evaluates the potential environmental impacts of issuing a Presidential permit for a new, 72-mile long, 1,000 megawatt, high-voltage direct current, electric transmission system that would cross the international border with Canada in Lake Erie and connect to the proposed Erie Converter Station in Conneaut Township, Pennsylvania. Additional information is available on the project website: http://www.lakeerieconnectorea.com.

  17. Energy Efficient Buildings, Salt Lake County, Utah

    SciTech Connect

    Barnett, Kimberly

    2012-04-30

    Executive Summary Salt Lake County's Solar Photovoltaic Project - an unprecedented public/private partnership Salt Lake County is pleased to announce the completion of its unprecedented solar photovoltaic (PV) installation on the Calvin R. Rampton Salt Palace Convention Center. This 1.65 MW installation will be one the largest solar roof top installations in the country and will more than double the current installed solar capacity in the state of Utah. Construction is complete and the system will be operational in May 2012. The County has accomplished this project using a Power Purchase Agreement (PPA) financing model. In a PPA model a third-party solar developer will finance, develop, own, operate, and maintain the solar array. Salt Lake County will lease its roof, and purchase the power from this third-party under a long-term Power Purchase Agreement contract. In fact, this will be one of the first projects in the state of Utah to take advantage of the recent (March 2010) legislation which makes PPA models possible for projects of this type. In addition to utilizing a PPA, this solar project will employ public and private capital, Energy Efficiency and Conservation Block Grants (EECBG), and public/private subsidized bonds that are able to work together efficiently because of the recent stimulus bill. The project also makes use of recent changes to federal tax rules, and the recent re-awakening of private capital markets that make a significant public-private partnership possible. This is an extremely innovative project, and will mark the first time that all of these incentives (EECBG grants, Qualified Energy Conservation Bonds, New Markets tax credits, investment tax credits, public and private funds) have been packaged into one project. All of Salt Lake County's research documents and studies, agreements, and technical information is available to the public. In addition, the County has already shared a variety of information with the public through webinars

  18. Stochastic Forecasting of Algae Blooms in Lakes

    SciTech Connect

    Wang, Peng; Tartakovsky, Daniel M.; Tartakovsky, Alexandre M.

    2013-01-15

    We consider the development of harmful algae blooms (HABs) in a lake with uncertain nutrients inflow. Two general frameworks, Fokker-Planck equation and the PDF methods, are developed to quantify the resultant concentration uncertainty of various algae groups, via deriving a deterministic equation of their joint probability density function (PDF). A computational example is examined to study the evolution of cyanobacteria (the blue-green algae) and the impacts of initial concentration and inflow-outflow ratio.

  19. Great Lakes Bioenergy Research Center Technology Marketing Summaries -

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Energy Innovation Portal Great Lakes Bioenergy Research Center Technology Marketing Summaries Here you'll find marketing summaries for technologies available for licensing from the Great Lakes Bioenergy Research Center (GLBRC). The summaries provide descriptions of the technologies including their benefits, applications and industries, and development stage. Great Lakes Bioenergy Research Center 43 Technology Marketing Summaries Category Title and Abstract Laboratories Date Biomass and

  20. Lake Elizabeth Micro-Utility | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Lake Elizabeth Micro-Utility Lake Elizabeth Micro-Utility New construction project consisting of 12 residential condominiums in a single 33,270 sq ft multi-story structure; 72-tons heating cooling. This effort exploits price discrepancies between commercial energy rates and geothermal space conditioning efficiencies to advantage the creation of a new service category. gshp_isaac_lake_elizabeth.html_.pdf (180.93 KB) More Documents & Publications CX-001203: Categorical Exclusion Determination

  1. Climate Action Champions: Blue Lake Rancheria Tribe, CA | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energy Blue Lake Rancheria Tribe, CA Climate Action Champions: Blue Lake Rancheria Tribe, CA The Blue Lake Rancheria, California, a federally recognized Native American tribal Government and community, is located on over 100 acres of land spanning the scenic Mad River in northwestern California. In its operational strategy, the Tribe has implemented the ‘seven generations’ philosophy, where actions taken today will have a positive impact for seven generations to come. This results

  2. Salt Lake County Residential Solar Financing Study | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Salt Lake County Residential Solar Financing Study Salt Lake County Residential Solar Financing Study As part of our engagement with the National Renewable Energy Laboratories conducting the Salt Lake County Solar America Residential Finance Study, we have drafted this report summarizing the tools and mechanisms available for residential solar projects. These include the financial incentives available, possible financing models that could be used in the County, and a review of the

  3. DOE Tour of Zero Floorplans: Lake Knowles by e2 Homes | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energy Lake Knowles by e2 Homes DOE Tour of Zero Floorplans: Lake Knowles by e2 Homes DOE Tour of Zero Floorplans: Lake Knowles by e2

  4. Paleoclimatic significance of lake level fluctuations in the Lahontan Basin. [Pyramid Lake, Nevada

    SciTech Connect

    Benson, L.V.

    1980-08-01

    An energy flux balance model has been developed which treats evaporation as a function of air temperature, surface water temperature, precipitable water aloft, the amount, height, and type of sky cover, and the optical air mass. The model has been used to estimate the mean historical evaporation rate for Pyramid Lake, Nevada, using as input climatic data from the Reno area averaged over the period 1950 to 1975. Estimated and measured values of the mean annual evaporation rate were found to be in good agreement. The model was used to simulate changes in the level, the surface area and the volume of paleo Lake Lahontan. In particular, possible climatic states responsible for past high stands (1270 and 1330 m) were investigated. A conservative range of discharge values was used in the calculations. Results of the simulations indicate the fundamental importance of sky cover in the creation and destruction of large lake systems.

  5. Star Lake, New York: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Lake, New York: Energy Resources Jump to: navigation, search Equivalent URI DBpedia Coordinates 44.159785, -75.0315825 Show Map Loading map... "minzoom":false,"mappingservice"...

  6. Green Lake County, Wisconsin: Energy Resources | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    Mackford, Wisconsin Markesan, Wisconsin Marquette, Wisconsin Princeton, Wisconsin St. Marie, Wisconsin Retrieved from "http:en.openei.orgwindex.php?titleGreenLakeCounty,W...

  7. Cloud Lake, Florida: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Cloud Lake, Florida: Energy Resources Jump to: navigation, search Equivalent URI DBpedia Coordinates 26.6761772, -80.0739308 Show Map Loading map... "minzoom":false,"mappingse...

  8. Lake Hart, Florida: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Lake Hart, Florida: Energy Resources Jump to: navigation, search Equivalent URI DBpedia Coordinates 28.3927849, -81.2406232 Show Map Loading map... "minzoom":false,"mappingser...

  9. Lake of the Woods County, Minnesota: Energy Resources | Open...

    OpenEI (Open Energy Information) [EERE & EIA]

    in Lake of the Woods County, Minnesota Baudette, Minnesota Roosevelt, Minnesota Williams, Minnesota Retrieved from "http:en.openei.orgwindex.php?titleLakeoftheWoodsC...

  10. Stepout-Deepening Wells At Medicine Lake Area (Warpinski, Et...

    OpenEI (Open Energy Information) [EERE & EIA]

    2) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Stepout-Deepening Wells At Medicine Lake Area (Warpinski, Et Al., 2002) Exploration Activity...

  11. East Soda Lake Geothermal Project | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    ","group":"","inlineLabel":"","visitedicon":"" Hide Map Location Fallon, NV County Churchill County, NV Geothermal Area Soda Lake Geothermal Area Geothermal Region Northwest...

  12. Isotopic Analysis At Clear Lake Area (Thompson, Et Al., 1992...

    OpenEI (Open Energy Information) [EERE & EIA]

    Exploration Activity Details Location Clear Lake Area Exploration Technique Isotopic Analysis- Fluid Activity Date Usefulness useful DOE-funding Unknown Notes Deuterium and...

  13. Lake Encroachment Permit Application, Abutting Land Owner Addendum...

    OpenEI (Open Energy Information) [EERE & EIA]

    Lake Encroachment Permit Application, Abutting Land Owner Addendum Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- Permit ApplicationPermit...

  14. Static Temperature Survey At Medicine Lake Area (Warpinski, Et...

    OpenEI (Open Energy Information) [EERE & EIA]

    GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Static Temperature Survey At Medicine Lake Area (Warpinski, Et Al., 2002) Exploration Activity Details Location Medicine...

  15. Lake Charles Liquefaction Project Final Environmental Impact Statement

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energy Regulatory Commission Office of Energy Projects Washington, DC 20426 Lake Charles Liquefaction Project Final Environmental Impact Statement Trunkline Gas Company, LLC, Lake Charles LNG Company, LLC, and Lake Charles LNG Export Company, LLC FERC Docket Nos. CP14-119-000, CP14-120-000, and CP14-122-000 DOE Docket Nos. 11-59-LNG and 13-04-LNG FERC/EIS-0258F, DOE/EIS-0491 Cooperating Agencies: U.S. Coast Guard U.S. Department of Energy U.S. Department of Transportation Lake Charles

  16. Data Acquisition-Manipulation At Lake City Hot Springs Area ...

    OpenEI (Open Energy Information) [EERE & EIA]

    Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Data Acquisition-Manipulation At Lake City Hot Springs Area (Warpinski, Et Al., 2004)...

  17. Blue Lake Plant Biomass Facility | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    National Map Retrieved from "http:en.openei.orgwindex.php?titleBlueLakePlantBiomassFacility&oldid397215" Feedback Contact needs updating Image needs updating...

  18. Salt Lake City, Utah: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Salt Lake City, Utah: Energy Resources Jump to: navigation, search Equivalent URI DBpedia Coordinates 40.7607793, -111.8910474 Show Map Loading map... "minzoom":false,"mapping...

  19. Price of Lake Charles, LA Liquefied Natural Gas Total Imports...

    Gasoline and Diesel Fuel Update

    Liquefied Natural Gas Total Imports (Dollars per Thousand Cubic Feet) Price of Lake Charles, LA Liquefied Natural Gas Total Imports (Dollars per Thousand Cubic Feet) Decade Year-0 ...

  20. Salt Lake County, Utah: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Creek Valley, Utah Magna, Utah Midvale, Utah Millcreek, Utah Mount Olympus, Utah Murray, Utah Riverton, Utah Salt Lake City, Utah Sandy, Utah South Jordan, Utah South Salt...

  1. Lake Forest, California: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Lake Forest, California: Energy Resources Jump to: navigation, search Equivalent URI DBpedia Coordinates 33.6469661, -117.689218 Show Map Loading map... "minzoom":false,"mappi...

  2. Lake Forest, Florida: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Lake Forest, Florida: Energy Resources Jump to: navigation, search Equivalent URI DBpedia Coordinates 30.3980165, -81.6737085 Show Map Loading map... "minzoom":false,"mappings...

  3. Angola on the Lake, New York: Energy Resources | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    Angola on the Lake, New York: Energy Resources Jump to: navigation, search Equivalent URI DBpedia Coordinates 42.6547811, -79.0489273 Show Map Loading map......

  4. Moose Lake Water & Light Comm | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Website: www.mooselakepower.com Facebook: https:www.facebook.compagesMoose-Lake-Water-Light-Commission445326012175319?frefts Outage Hotline: (218) 485-4100 References:...

  5. Iowa Lakes Community College Wind Farm | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Community College Energy Purchaser Iowa Lakes Community College Location Esterville IA Coordinates 43.397912, -94.81768 Show Map Loading map... "minzoom":false,"mappingse...

  6. Lake Country Wind Energy LLC | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Wind Energy LLC Jump to: navigation, search Name: Lake Country Wind Energy LLC Place: Minnesota Zip: 56209 Sector: Renewable Energy, Wind energy Product: Minnesota-based wind...

  7. Taylor Lake Village, Texas: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    dataset (All States, all geography) US Census Bureau Congressional Districts by Places. Retrieved from "http:en.openei.orgwindex.php?titleTaylorLakeVillage,Texas&oldid...

  8. Marion Lake, Minnesota: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Marion Lake, Minnesota: Energy Resources Jump to: navigation, search Equivalent URI DBpedia Coordinates 47.1383694, -91.9960581 Show Map Loading map... "minzoom":false,"mappin...

  9. Time-Domain Electromagnetics At Soda Lake Area (Combs 2006) ...

    OpenEI (Open Energy Information) [EERE & EIA]

    Time-Domain Electromagnetics At Soda Lake Area (Combs 2006) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Time-Domain Electromagnetics At Soda...

  10. Compound and Elemental Analysis At Clear Lake Area (Thompson...

    OpenEI (Open Energy Information) [EERE & EIA]

    Details Location Clear Lake Area Exploration Technique Compound and Elemental Analysis Activity Date Usefulness useful DOE-funding Unknown Notes Based on the above discussion,...

  11. Geothermometry At Clear Lake Area (Thompson, Et Al., 1992) |...

    OpenEI (Open Energy Information) [EERE & EIA]

    Activity Details Location Clear Lake Area Exploration Technique Geothermometry Activity Date Usefulness useful DOE-funding Unknown Notes Based on the above discussion,...

  12. Mountain Lakes, New Jersey: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Mountain Lakes, New Jersey: Energy Resources Jump to: navigation, search Equivalent URI DBpedia Coordinates 40.8948212, -74.4329314 Show Map Loading map......

  13. Compound and Elemental Analysis At Fish Lake Valley Area (Deymonaz...

    OpenEI (Open Energy Information) [EERE & EIA]

    ENERGYGeothermal Home Exploration Activity: Compound and Elemental Analysis At Fish Lake Valley Area (Deymonaz, Et Al., 2008) Exploration Activity Details Location Fish...

  14. Ground Gravity Survey At Lake City Hot Springs Area (Warpinski...

    OpenEI (Open Energy Information) [EERE & EIA]

    Exploration Activity Details Location Lake City Hot Springs Area Exploration Technique Ground Gravity Survey Activity Date Usefulness not indicated DOE-funding Unknown Notes The...

  15. Heat flow studies, Coso Geothermal Area, China Lake, California...

    OpenEI (Open Energy Information) [EERE & EIA]

    Heat flow studies in the Coso Geothermal Area were conducted at China Lake, California. Temperature measurements were completed in nine of the heat flow boreholes. Temperatures...

  16. China Lake South Range Geothermal Project | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Development Project: China Lake South Range Geothermal Project Project Location Information Coordinates 35.65,...

  17. City of Lake Park, Iowa (Utility Company) | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    City of Place: Iowa Phone Number: (712) 832-3667 Website: www.lakeparkia.comindex.phpl Facebook: https:www.facebook.compagesLake-Park-Iowa104075932961159 Outage Hotline:...

  18. Glen Canyon National Recreation Area, Lake Powell, Utah | Department...

    Energy Saver

    Glen Canyon National Recreation Area, Lake Powell, Utah Photo of the Photovoltaic System ... Consequently, the installation of a photovoltaic (PV) system presented many advantages. ...

  19. Palmer Lake, Colorado: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    district.12 Registered Energy Companies in Palmer Lake, Colorado American Electric Vehicles Inc References US Census Bureau Incorporated place and minor civil...

  20. Lazy Lake, Florida: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    it. Lazy Lake is a village in Broward County, Florida. It falls under Florida's 20th congressional district.12 References US Census Bureau Incorporated place and...

  1. Lauderdale Lakes, Florida: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    it. Lauderdale Lakes is a city in Broward County, Florida. It falls under Florida's 20th congressional district and Florida's 23rd congressional district.12 References ...

  2. Acomita Lake, New Mexico: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Acomita Lake, New Mexico: Energy Resources Jump to: navigation, search Equivalent URI DBpedia Coordinates 35.0703192, -107.6136628 Show Map Loading map... "minzoom":false,"map...

  3. Seismic Structure And Seismicity Of The Cooling Lava Lake Of...

    OpenEI (Open Energy Information) [EERE & EIA]

    Of The Cooling Lava Lake Of Kilauea Iki, Hawaii Abstract The use of multiple methods is indispensable for the determination of the seismic properties of a complex body...

  4. Compound and Elemental Analysis At Lake City Hot Springs Area...

    OpenEI (Open Energy Information) [EERE & EIA]

    Date Usefulness useful DOE-funding Unknown References Chris Sladek, Greg B. Arehart, Walter R. Benoit (2004) Geochemistry Of The Lake City Geothermal System, California, Usa...

  5. Lake County- Energy Smart Colorado Energy Efficiency Rebate Program

    Energy.gov [DOE]

    Residents of Roaring Fork Valley and Eagle, Gunnison, Lake, and Summit Counties are eligible for energy efficiency and renewable energy assistance, rebates, and financing through the Energy Smart...

  6. Lake County- Energy Smart Colorado Renewable Energy Rebate Program

    Energy.gov [DOE]

    Residents of Roaring Fork Valley and Eagle, Gunnison, Lake, and Summit Counties are eligible for energy efficiency and renewable energy assistance, rebates, and financing through the Energy Smart...

  7. The Great Lakes Insitute for Energy Innovation | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    Insitute for Energy Innovation Jump to: navigation, search Name: The Great Lakes Insitute for Energy Innovation Place: Cleveland, Ohio Zip: 44106 Website: energy.case.edu...

  8. Hush Lake, Minnesota: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Hush Lake, Minnesota: Energy Resources Jump to: navigation, search Equivalent URI DBpedia Coordinates 47.4494204, -92.1031839 Show Map Loading map... "minzoom":false,"mappings...

  9. Cordes Lakes, Arizona: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Lakes, Arizona: Energy Resources Jump to: navigation, search Equivalent URI DBpedia Coordinates 34.3078074, -112.1034912 Show Map Loading map... "minzoom":false,"mappingservic...

  10. Klamath and Lake Counties Agricultural Industrial Park | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Klamath and Lake Counties Agricultural Industrial Park; 2010 Geothermal Technology Program Peer Review Report Purchase and Installation of a Geothermal Power Plant to Generate ...

  11. EIS-0498: Magnolia LNG and Lake Charles Expansion Projects; Calcasieu...

    Energy Saver

    with the public interest. EIS-0498: Magnolia LNG and Lake Charles Expansion Projects Public Comment Opportunities No public comment opportunities available at this time....

  12. Geothermal Literature Review At Lake City Hot Springs Area (Benoit...

    OpenEI (Open Energy Information) [EERE & EIA]

    navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Geothermal Literature Review At Lake City Hot Springs Area (Benoit, Et Al., 2004) Exploration Activity...

  13. Groundwater recharge from Long Lake, Indiana Dunes National Lakeshore

    SciTech Connect

    Isiorho, S.A.; Beeching, F.M. (Indiana Univ., Fort Wayne, IN (United States). Geosciences Dept.); Whitman, R.L.; Stewart, P.M. (National Park Services, Porter, IN (United States). Indiana Dunes National Lakeshore); Gentleman, M.A.

    1992-01-01

    Long Lake, located between Lake Michigan and the Dune-complexes of Indiana Dunes, was formed during Pleistocene and Holocene epochs. The lake is currently being studied to understand the detailed hydrology. One of the objective of the study is to understand the hydrologic relationship between the lake and a water treatment holding pond to the northeast. Understanding the water movement between the two bodies of water, if any, would be very important in the management and protection of nature preserves in the area. Seepage measurement and minipiezometric tests indicate groundwater recharge from Long Lake. The groundwater recharge rate is approximately 1.40 to 22.28 x 10[sup [minus]4] m/day. An estimate of the amount of recharge of 7.0 x 10[sup 6] m[sup 3]/y may be significant in terms of groundwater recharge of the upper aquifer system of the Dunes area. The water chemistry of the two bodies of water appears to be similar, however, the pH of the holding pond is slightly alkaline (8.5) while that of Long Lake is less alkaline (7.7). There appears to be no direct contact between the two bodies of water (separated by approximately six meters of clay rich sediment). The geology of the area indicates a surficial aquifer underlying Long Lake. The lake should be regarded as a recharge area and should be protected from pollutants as the degradation of the lake would contaminate the underlying aquifer.

  14. Facies distributions within contrasting structural components of a rift lake: Lake Tanganyika, Africa

    SciTech Connect

    Soreghan, M.J.; Cohen, A.S. )

    1991-03-01

    Lake Tanganyika is the most widely cited modern analog for interpreting ancient rift lakes; thus, understanding controls on its facies distribution is critical for refining stratigraphic models for rifts. Four recurrent margin types occur along the alternating half-graben structure of the lake: rift axes, platforms, escarpments, and accommodation zones. Data from study sites in the northern part of the lake suggest that predictable facies differences exist between these structural margin types. The rift axis site comprises a low-gradient, clastic (wave/current)-dominated deltaic system, with strong facies asymmetry and minor carbonate accumulations on raised benches. The platform margin site comprises a series of structurally controlled benches over which long, continuous facies tracts occur. Carbonate sands, muds, and shell gravel dominate; clastics are limited to moderate-sized silty deltas and long, narrow shoreface sands. The escarpment margin site is a steep-gradient system along which small ({lt}1 km{sup 2}) fan deltas alternate with cemented talus. The accommodation zone margin sites are also dominated by rugged structural relief, generally small fan deltas, and semicontinuous shoreface sand belts ({gt}5 km) onshore and poorly sorted silts offshore. TOC from fine-grained samples reflects the contrast in margin types. TOC values for the platform and rift axis range from 0.4 - 2.1 wt. % (avg. 1.3%), whereas accommodation zone and escarpment margin values range from 0.5-5.5% (avg. 3.0%). Acid insoluble sulfur shows a similar trend. Although all data are significantly correlated with depth, the relative area of the lake margin above and below the oxicline is directly controlled by the structural style of the lake margin.

  15. MicroRNAs expression in ox-LDL treated HUVECs: MiR-365 modulates apoptosis and Bcl-2 expression

    SciTech Connect

    Qin, Bing; Xiao, Bo; Liang, Desheng; Xia, Jian; Li, Ye; Yang, Huan

    2011-06-24

    Highlights: {yields} We evaluated the role of miRNAs in ox-LDL induced apoptosis in ECs. {yields} We found 4 up-regulated and 11 down-regulated miRNAs in apoptotic ECs. {yields} Target genes of the dysregulated miRNAs regulate ECs apoptosis and atherosclerosis. {yields} MiR-365 promotes ECs apoptosis via suppressing Bcl-2 expression. {yields} MiR-365 inhibitor alleviates ECs apoptosis induced by ox-LDL. -- Abstract: Endothelial cells (ECs) apoptosis induced by oxidized low-density lipoprotein (ox-LDL) is thought to play a critical role in atherosclerosis. MicroRNAs (miRNAs) are a class of noncoding RNAs that posttranscriptionally regulate the expression of genes involved in diverse cell functions, including differentiation, growth, proliferation, and apoptosis. However, whether miRNAs are associated with ox-LDL induced apoptosis and their effect on ECs is still unknown. Therefore, this study evaluated potential miRNAs and their involvement in ECs apoptosis in response to ox-LDL stimulation. Microarray and qRT-PCR analysis performed on human umbilical vein endothelial cells (HUVECs) exposed to ox-LDL identified 15 differentially expressed (4 up- and 11 down-regulated) miRNAs. Web-based query tools were utilized to predict the target genes of the differentially expressed miRNAs, and the potential target genes were classified into different function categories with the gene ontology (GO) term and KEGG pathway annotation. In particular, bioinformatics analysis suggested that anti-apoptotic protein B-cell CLL/lymphoma 2 (Bcl-2) is a target gene of miR-365, an apoptomir up-regulated by ox-LDL stimulation in HUVECs. We further showed that transfection of miR-365 inhibitor partly restored Bcl-2 expression at both mRNA and protein levels, leading to a reduction of ox-LDL-mediated apoptosis in HUVECs. Taken together, our findings indicate that miRNAs participate in ox-LDL-mediated apoptosis in HUVECs. MiR-365 potentiates ox-LDL-induced ECs apoptosis by regulating the

  16. Development Wells At Soda Lake Area (DOE GTP) | Open Energy Informatio...

    OpenEI (Open Energy Information) [EERE & EIA]

    Soda Lake Area (DOE GTP) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Development Wells At Soda Lake Area (DOE GTP) Exploration Activity...

  17. Reflection Survey At Soda Lake Area (DOE GTP) | Open Energy Informatio...

    OpenEI (Open Energy Information) [EERE & EIA]

    Soda Lake Area (DOE GTP) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Reflection Survey At Soda Lake Area (DOE GTP) Exploration Activity...

  18. Fond du Lac Band Leads Climate Resilience Efforts on Lake Superior...

    Energy Saver

    Fond du Lac Band Leads Climate Resilience Efforts on Lake Superior Chippewa Indian Reservation Fond du Lac Band Leads Climate Resilience Efforts on Lake Superior Chippewa Indian ...

  19. Water Sampling At Hot Lake Area (Wood, 2002) | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Water Sampling At Hot Lake Area (Wood, 2002) Exploration Activity Details Location Hot Lake...

  20. Monitoring the Effect of Injection of Fluids from the Lake County...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    the Lake County Pipeline on Seismicity at The Geysers, California Geothermal Field. Monitoring the Effect of Injection of Fluids from the Lake County Pipeline on Seismicity at ...

  1. Reflection Survey At Fish Lake Valley Area (DOE GTP) | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    Fish Lake Valley Area (DOE GTP) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Reflection Survey At Fish Lake Valley Area (DOE GTP) Exploration...

  2. Field Mapping At Fish Lake Valley Area (DOE GTP) | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Field Mapping At Fish Lake Valley Area (DOE GTP) Exploration Activity Details Location Fish Lake Valley Area...

  3. Density Log at Fish Lake Valley Area (DOE GTP) | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    Fish Lake Valley Area (DOE GTP) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Density Log at Fish Lake Valley Area (DOE GTP) Exploration...

  4. Thermal Gradient Holes At Fish Lake Valley Area (DOE GTP) | Open...

    OpenEI (Open Energy Information) [EERE & EIA]

    Fish Lake Valley Area (DOE GTP) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Thermal Gradient Holes At Fish Lake Valley Area (DOE GTP)...

  5. Slim Holes At Fish Lake Valley Area (Deymonaz, Et Al., 2008)...

    OpenEI (Open Energy Information) [EERE & EIA]

    Fish Lake Valley Area (Deymonaz, Et Al., 2008) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Slim Holes At Fish Lake Valley Area (Deymonaz, Et...

  6. Core Analysis At Fish Lake Valley Area (DOE GTP) | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    Fish Lake Valley Area (DOE GTP) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Core Analysis At Fish Lake Valley Area (DOE GTP) Exploration...

  7. Flow Test At Fish Lake Valley Area (DOE GTP) | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Fish Lake Valley Area (DOE GTP) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Flow Test At Fish Lake Valley Area (DOE GTP) Exploration Activity...

  8. Resistivity Log At Fish Lake Valley Area (DOE GTP) | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    Fish Lake Valley Area (DOE GTP) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Resistivity Log At Fish Lake Valley Area (DOE GTP) Exploration...

  9. Thermal And-Or Near Infrared At Fish Lake Valley Area (Deymonaz...

    OpenEI (Open Energy Information) [EERE & EIA]

    Fish Lake Valley Area (Deymonaz, Et Al., 2008) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Thermal And-Or Near Infrared At Fish Lake Valley...

  10. Pressure Temperature Log At Soda Lake Area (DOE GTP) | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Pressure Temperature Log At Soda Lake Area (DOE GTP) Exploration Activity Details Location Soda Lake...

  11. Flow Test At Soda Lake Area (DOE GTP) | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Flow Test At Soda Lake Area (DOE GTP) Exploration Activity Details Location Soda Lake Area...

  12. MiRNA-125a-5p inhibits glioblastoma cell proliferation and promotes cell differentiation by targeting TAZ

    SciTech Connect

    Yuan, Jian; Xiao, Gelei; Peng, Gang; Liu, Dingyang; Wang, Zeyou; Liao, Yiwei; Liu, Qing; Wu, Minghua; Yuan, Xianrui

    2015-02-06

    Highlights: • Expression of miR-125a-5p is inversely correlated with that of TAZ in glioma cells. • MiR-125a-5p represses TAZ expression in glioma cells. • MiR-125a-5p directly targets the 3′ UTR of TAZ mRNA and promotes its degradation. • MiR-125a-5p represses CTGF and survivin via TAZ, and inhibits glioma cell growth. • MiR-125a-5p inhibits the stem cell features of HFU-251 MG cells. - Abstract: Glioblastoma (GBM) is the most lethal brain tumor due to the resistance to conventional therapies, such as radiotherapy and chemotherapy. TAZ, an important mediator of the Hippo pathway, was found to be up-regulated in diverse cancers, including in GBM, and plays important roles in tumor initiation and progression. However, little is known about the regulation of TAZ expression in tumors. In this study, we found that miR-125a-5p is an important regulator of TAZ in glioma cells by directly targeting the TAZ 3′ UTR. MiR-125a-5p levels are inversely correlated with that of TAZ in normal astrocytes and a panel of glioma cell lines. MiR-125a-5p represses the expression of TAZ target genes, including CTGF and survivin, and inhibits cell proliferation and induces the differentiation of GBM cells; whereas over-expression of TAZ rescues the effects of miR-125a-5p. This study revealed a mechanism for TAZ deregulation in glioma cells, and also demonstrated a tumor suppressor role of miR-125a-5p in glioblastoma cells.

  13. The NuMI proton beam at Fermilab successes and challenges

    SciTech Connect

    Childress, S.; /Fermilab

    2008-11-01

    The NuMI beam at Fermilab has delivered over 5 x 10{sup 20} 120 GeV protons to the neutrino production target since the start for MINOS [1] neutrino oscillation experiment operation in 2005. We report on proton beam commissioning and operation status, including successes and challenges with this beam.

  14. DOE Zero Energy Ready Home Case Study: Cobblestone Homes, Midland, MI

    Office of Energy Efficiency and Renewable Energy (EERE)

    Case study of a DOE Zero Energy Ready home in Midland, MI, that scored HERS 49 without PV or HERS 44 with 1.4 kW of PV. The custom home served as a prototype and energy efficiency demonstration...

  15. MiR-18a regulates the proliferation, migration and invasion of human glioblastoma cell by targeting neogenin

    SciTech Connect

    Song, Yichen; Wang, Ping; Zhao, Wei; Yao, Yilong; Liu, Xiaobai; Ma, Jun; Xue, Yixue; Liu, Yunhui

    2014-05-15

    MiR-17-92 cluster has recently been reported as an oncogene in some tumors. However, the association of miR-18a, an important member of this cluster, with glioblastoma remains unknown. Therefore, this study aims to investigate the expression of miR-18a in glioblastoma and its role in biological behavior of U87 and U251 human glioblastoma cell lines. Quantitative RT-PCR results showed that miR-18a was highly expressed in glioblastoma tissues and U87 and U251 cell lines compared with that in human brain tissues and primary normal human astrocytes, and the expression levels were increased along with the rising pathological grades of glioblastoma. Neogenin was identified as the target gene of miR-18a by dual-luciferase reporter assays. RT-PCR and western blot results showed that its expression levels were decreased along with the rising pathological grades of glioblastoma. Inhibition of miR-18a expression was established by transfecting exogenous miR-18a inhibitor into U87 and U251 cells, and its effects on the biological behavior of glioblastoma cells were studied using CCK-8 assay, transwell assay and flow cytometry. Inhibition of miR-18a expression in U87 and U251 cells significantly up-regulated neogenin, and dramatically suppressed the abilities of cell proliferation, migration and invasion, induced cell cycle arrest and promoted cellular apoptosis. Collectively, these results suggest that miR-18a may regulate biological behavior of human glioblastoma cells by targeting neogenin, and miR-18a can serve as a potential target in the treatment of glioblastoma. - Highlights: • MiR-18a was highly expressed in glioblastoma tissues and U87 and U251 cell lines. • Neogenin was identified as the target gene of miR-18a. • Neogenin expressions were decreased along with the rising pathological grades of glioblastoma. • Inhibition of miR-18a suppressed biological behavior of glioma cells by up-regulating neogenin.

  16. Building America Case Study: Apartment Compartmentalization with an Aerosol-Based Sealing Process - Queens, NY; Technology Solutions for New and Existing Homes, Energy Efficiency & Renewable Energy (EERE)

    SciTech Connect

    2015-07-01

    Air sealing of building enclosures is a difficult and time-consuming process. Current methods in new construction require laborers to physically locate small and sometimes large holes in multiple assemblies and then manually seal each of them. The innovation demonstrated under this research study was the automated air sealing and compartmentalization of buildings through the use of an aerosolized sealant, developed by the Western Cooling Efficiency Center at University of California Davis.
    CARB sought to demonstrate this new technology application in a multifamily building in Queens, NY. The effectiveness of the sealing process was evaluated by three methods: air leakage testing of overall apartment before and after sealing, point-source testing of individual leaks, and pressure measurements in the walls of the target apartment during sealing. Aerosolized sealing was successful by several measures in this study. Many individual leaks that are labor-intensive to address separately were well sealed by the aerosol particles. In addition, many diffuse leaks that are difficult to identify and treat were also sealed. The aerosol-based sealing process resulted in an average reduction of 71% in air leakage across three apartments and an average apartment airtightness of 0.08 CFM50/SF of enclosure area.

  17. miR-7 and miR-218 epigenetically control tumor suppressor genes RASSF1A and Claudin-6 by targeting HoxB3 in breast cancer

    SciTech Connect

    Li, Qiaoyan; Zhu, Fufan; Chen, Puxiang

    2012-07-20

    Highlights: Black-Right-Pointing-Pointer Both miR-7 and miR-218 down-regulates HoxB3 expression by targeting the 3 Prime -UTR of HoxB3 mRNA. Black-Right-Pointing-Pointer A reverse correlation between the levels of endogenous miR-7, miR218 and HoxB3 expression. Black-Right-Pointing-Pointer Epigenetic changes involve in the reactivation of HoxB3. Black-Right-Pointing-Pointer Both miRNAs inhibits the cell cycle and clone formation of breast cancer cells. -- Abstract: Many microRNAs have been implicated as key regulators of cellular growth and differentiation and have been found to dysregulate proliferation in human tumors, including breast cancer. Cancer-linked microRNAs also alter the epigenetic landscape by way of DNA methylation and post-translational modifications of histones. Aberrations in Hox gene expression are important for oncogene or tumor suppressor during abnormal development and malignancy. Although recent studies suggest that HoxB3 is critical in breast cancer, the putative role(s) of microRNAs impinging on HoxB3 is not yet fully understood. In this study, we found that the expression levels of miR-7 and miR-218 were strongly and reversely associated with HoxB3 expression. Stable overexpression of miR-7 and miR-218 was accompanied by reactivation of tumor suppressor genes including RASSF1A and Claudin-6 by means of epigenetic switches in DNA methylation and histone modification, giving rise to inhibition of the cell cycle and clone formation of breast cancer cells. The current study provides a novel link between overexpression of collinear Hox genes and multiple microRNAs in human breast malignancy.

  18. Loss of expression of miR-335 is implicated in hepatic stellate cell migration and activation

    SciTech Connect

    Chen, Chao; Wu, Chao-Qun; Zhang, Zong-Qi; Yao, Ding-Kang; Zhu, Liang

    2011-07-15

    Activation and migration of resident stellate cells (HSCs) within the hepatic space of Disse play an important role in hepatic fibrosis, which accounts for the increased numbers of activated HSCs in areas of inflammation during hepatic fibrosis. Currently, microRNAs have been found to play essential roles in HSC differentiation, proliferation, apoptosis, fat accumulation and collagen production. However, little is known about microRNA mediated HSC activation and migration. In this study, the miRNA expression profiles of quiescent HSCs, partially activated HSCs and fully activated HSCs were compared in pairs. Gene ontology (GO) and GO-Map network analysis indicated that the activation of HSCs was regulated by microRNAs. Among them miR-335 was confirmed to be significantly reduced during HSC activation by qRT-PCR, and restoring expression of miR-335 inhibited HSC migration and reduced {alpha}-SMA and collagen type I. Previous study revealed that tenascin-C (TNC), an extracellular matrix glycoprotein involved in cell migration, might be a target of miR-335. Therefore, we further studied the TNC expression in miR-335 over-expressed HSCs. Our data showed that exogenous TNC could enhance HSC migration in vitro and miR-335 restoration resulted in a significant inhibition of TNC expression. These results demonstrated that miR-335 restoration inhibited HSC migration, at least in part, via downregulating the TNC expression.

  19. PSMB4 promotes multiple myeloma cell growth by activating NF-κB-miR-21 signaling

    SciTech Connect

    Zheng, Peihao; Guo, Honggang; Li, Guangchao; Han, Siqi; Luo, Fei; Liu, Yi

    2015-03-06

    Proteasomal subunit PSMB4, was recently identified as potential cancer driver genes in several tumors. However, the regulatory mechanism of PSMB4 on carcinogenesis process remains unclear. In this study, we investigated the expression and roles of PSMB4 in multiple myeloma (MM). We found a significant up-regulation of PSMB4 in MM plasma and cell lines. Ectopic overexpression of PSMB4 promoted cell growth and colony forming ability of MM cells, whereas inhibition of PSMB4 led to a decrease of such events. Furthermore, our results demonstrated the up-regulation of miR-21 and a positive correlation between the levels of miR-21 and PSMB4 in MM. Re-expression of miR-21 markedly rescued PSMB4 knockdown-mediated suppression of cell proliferation and clone-formation. Additionally, while enforced expression of PSMB4 profoundly increased NF-κB activity and the level of miR-21, PSMB4 knockdown or NF-κB inhibition suppressed miR-21 expression in MM cells. Taken together, our results demonstrated that PSMB4 regulated MM cell growth in part by activating NF-κB-miR-21 signaling, which may represent promising targets for novel specific therapies. - Highlights: • First reported upregulation of PSMB4 in MM plasma and cell lines. • PSMB4 promoted MM cell growth and colony forming ability. • Further found miR-21 was up-regulated by PSMB4 in MM plasma and cell lines. • PSMB4-induced miR-21 expression was modulated by NF-κB. • PSMB4-NF-κB-miR-21 axis may be potential therapeutic targets of MM.

  20. Assessment of Biomass Energy Opportunities for the Red Lake Band of Chippewa Indians

    SciTech Connect

    Scott Haase

    2005-09-30

    Assessment of biomass energy and biobased product manufacturing opportunities for the Red Lake Tribe.

  1. U.S. Total Exports

    Energy Information Administration (EIA) (indexed site)

    Sabine Pass, LA Total To Barbados Miami, FL Total To Brazil Freeport, TX Sabine Pass, LA Total to Canada Eastport, ID Calais, ME Detroit, MI Marysville, MI Port Huron, MI Portal, ND Sault St. Marie, MI St. Clair, MI Noyes, MN Babb, MT Havre, MT Port of Morgan, MT Sherwood, ND Pittsburg, NH Grand Island, NY Massena, NY Niagara Falls, NY Waddington, NY Sumas, WA Sweetgrass, MT Total to Chile Sabine Pass, LA Total to China Kenai, AK Sabine Pass, LA Total to Dominican Republic Sabine Pass, LA Total

  2. RLIP76-dependent suppression of PI3K/AKT/Bcl-2 pathway by miR...

    Office of Scientific and Technical Information (OSTI)

    in prostate cancer Citation Details In-Document Search Title: RLIP76-dependent suppression of PI3KAKTBcl-2 pathway by miR-101 induces apoptosis in prostate cancer MicroRNA-101 ...

  3. Aryl hydrocarbon receptor-dependent regulation of miR-196a expression controls lung fibroblast apoptosis but not proliferation

    SciTech Connect

    Hecht, Emelia; Zago, Michela; Sarill, Miles; Rico de Souza, Angela; Gomez, Alvin; Matthews, Jason; Hamid, Qutayba; Eidelman, David H.; Baglole, Carolyn J.

    2014-11-01

    The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor implicated in the regulation of apoptosis and proliferation. Although activation of the AhR by xenobiotics such as dioxin inhibits the cell cycle and control apoptosis, paradoxically, AhR expression also promotes cell proliferation and survival independent of exogenous ligands. The microRNA (miRNA) miR-196a has also emerged as a regulator of proliferation and apoptosis but a relationship between the AhR and miR-196a is not known. Therefore, we hypothesized that AhR-dependent regulation of endogenous miR-196a expression would promote cell survival and proliferation. Utilizing lung fibroblasts from AhR deficient (AhR{sup −/−}) and wild-type (AhR{sup +/+}) mice, we show that there is ligand-independent regulation of miRNA, including low miR-196a in AhR{sup −/−} cells. Validation by qRT-PCR revealed a significant decrease in basal expression of miR-196a in AhR{sup −/−} compared to AhR{sup +/+} cells. Exposure to AhR agonists benzo[a]pyrene (B[a]P) and FICZ as well as AhR antagonist CH-223191 decreased miR-196a expression in AhR{sup +/+} fibroblasts concomitant with decreased AhR protein levels. There was increased proliferation only in AhR{sup +/+} lung fibroblasts in response to serum, corresponding to a decrease in p27{sup KIP1} protein, a cyclin-dependent kinase inhibitor. Increasing the cellular levels of miR-196a had no effect on proliferation or expression of p27{sup KIP1} in AhR{sup −/−} fibroblasts but attenuated cigarette smoke-induced apoptosis. This study provides the first evidence that AhR expression is essential for the physiological regulation of cellular miRNA levels- including miR-196a. Future experiments designed to elucidate the functional relationship between the AhR and miR-196a may delineate additional novel ligand-independent roles for the AhR. - Highlights: • The AhR controls proliferation and apoptosis in lung cells. • The AhR regulates the

  4. Identifying Oil Exploration Leads using Intergrated Remote Sensing and Seismic Data Analysis, Lake Sakakawea, Fort Berthold Indian Reservation, Willistion Basin

    SciTech Connect

    Scott R. Reeves; Randal L. Billingsley

    2004-02-26

    The Fort Berthold Indian Reservation, inhabited by the Arikara, Mandan and Hidatsa Tribes (now united to form the Three Affiliated Tribes) covers a total area of 1530 mi{sup 2} (980,000 acres). The Reservation is located approximately 15 miles east of the depocenter of the Williston basin, and to the southeast of a major structural feature and petroleum producing province, the Nesson anticline. Several published studies document the widespread existence of mature source rocks, favorable reservoir/caprock combinations, and production throughout the Reservation and surrounding areas indicating high potential for undiscovered oil and gas resources. This technical assessment was performed to better define the oil exploration opportunity, and stimulate exploration and development activities for the benefit of the Tribes. The need for this assessment is underscored by the fact that, despite its considerable potential, there is currently no meaningful production on the Reservation, and only 2% of it is currently leased. Of particular interest (and the focus of this study) is the area under the Lake Sakakawea (formed as result of the Garrison Dam). This 'reservoir taking' area, which has never been drilled, encompasses an area of 150,000 acres, and represents the largest contiguous acreage block under control of the Tribes. Furthermore, these lands are Tribal (non-allotted), hence leasing requirements are relatively simple. The opportunity for exploration success insofar as identifying potential leads under the lake is high. According to the Bureau of Land Management, there have been 591 tests for oil and gas on or immediately adjacent to the Reservation, resulting in a total of 392 producing wells and 179 plugged and abandoned wells, for a success ratio of 69%. Based on statistical probability alone, the opportunity for success is high.

  5. Material Activation Benchmark Experiments at the NuMI Hadron Absorber Hall in Fermilab

    SciTech Connect

    Matsumura, H.; Matsuda, N.; Kasugai, Y.; Toyoda, A.; Yashima, H.; Sekimoto, S.; Iwase, H.; Oishi, K.; Sakamoto, Y.; Nakashima, H.; Leveling, A.; Boehnlein, D.; Lauten, G.; Mokhov, N.; Vaziri, K.

    2014-06-15

    In our previous study, double and mirror symmetric activation peaks found for Al and Au arranged spatially on the back of the Hadron absorber of the NuMI beamline in Fermilab were considerably higher than those expected purely from muon-induced reactions. From material activation bench-mark experiments, we conclude that this activation is due to hadrons with energy greater than 3 GeV that had passed downstream through small gaps in the hadron absorber.

  6. Comparative analysis of discharges into Lake Michigan, Phase I - Southern Lake Michigan.

    SciTech Connect

    Veil, J. A.; Elcock, D.; Gasper, J. R.; Environmental Science Division

    2008-06-30

    BP Products North America Inc. (BP) owns and operates a petroleum refinery located on approximately 1,700 acres in Whiting, East Chicago, and Hammond, Indiana, near the southern tip of Lake Michigan. BP provided funding to Purdue University-Calumet Water Institute (Purdue) and Argonne National Laboratory (Argonne) to conduct studies related to wastewater treatment and discharges. Purdue and Argonne are working jointly to identify and characterize technologies that BP could use to meet the previous discharge permit limits for total suspended solids (TSS) and ammonia after refinery modernization. In addition to the technology characterization work, Argonne conducted a separate project task, which is the subject of this report. In Phase I of a two-part study, Argonne estimated the current levels of discharge to southern Lake Michigan from significant point and nonpoint sources in Illinois, Indiana, and portions of Michigan. The study does not consider all of the chemicals that are discharged. Rather, it is narrowly focused on a selected group of pollutants, referred to as the 'target pollutants'. These include: TSS, ammonia, total and hexavalent chromium, mercury, vanadium, and selenium. In Phase II of the study, Argonne will expand the analysis to cover the entire Lake Michigan drainage basin.

  7. Measurement of Pi-K Ratios from the NuMI Target

    SciTech Connect

    Seun, Sin Man

    2007-07-01

    Interactions of protons (p) with the NuMI (Neutrinos at the Main Injector) target are used to create the neutrino beam for the MINOS (Main Injector Neutrino Oscillation Search) Experiment. Using the MIPP (Main Injector Particle Production) experimental apparatus, the production of charged pions and kaons in p+NuMI interactions is studied. The data come from a sample of 2 x 106 events obtained by MIPP using the 120 GeV/c proton beam from the Main Injector at Fermi National Accelerator Laboratory in Illinois, USA. Pions and kaons are identified by measurement in a Ring Imaging Cherenkov detector. Presented are measurements of π-+, K-/K+, π+/K+ and π-/K- production ratios in the momentum range pT < 2 GeV/c transversely and 20 GeV/c < pz < 90 GeV/c longitudinally. Also provided are detailed comparisons of the MIPP NuMI data with the MIPP Thin Carbon data, the MIPP Monte Carlo simulation and the current MINOS models in the relevant momentum ranges.

  8. miR-21 modulates tumor outgrowth induced by human adipose tissue-derived mesenchymal stem cells in vivo

    SciTech Connect

    Shin, Keun Koo; Lee, Ae Lim; Kim, Jee Young; Medical Research Center for Ischemic Tissue Engineering, Pusan National University, Yangsan, Gyeongnam 626-870; BK21 Medical Science Education Center, School of Medicine, Pusan National University, Yangsan, Gyeongnam 626-870 ; Lee, Sun Young; Medical Research Center for Ischemic Tissue Engineering, Pusan National University, Yangsan, Gyeongnam 626-870 ; Bae, Yong Chan; Jung, Jin Sup

    2012-06-15

    Highlights: Black-Right-Pointing-Pointer miR-21 modulates hADSC-induced increase of tumor growth. Black-Right-Pointing-Pointer The action is mostly mediated by the modulation of TGF-{beta} signaling. Black-Right-Pointing-Pointer Inhibition of miR-21 enhances the blood flow recovery in hindlimb ischemia. -- Abstract: Mesenchymal stem cells (MSCs) have generated a great deal of interest in clinical situations, due principally to their potential use in regenerative medicine and tissue engineering applications. However, the therapeutic application of MSCs remains limited, unless the favorable effects of MSCs on tumor growth in vivo, and the long-term safety of the clinical applications of MSCs, can be more thoroughly understood. In this study, we determined whether microRNAs can modulate MSC-induced tumor outgrowth in BALB/c nude mice. Overexpression of miR-21 in human adipose-derived stem cells (hADSCs) inhibited hADSC-induced tumor growth, and inhibition of miR-21 increased it. Downregulation of transforming growth factor beta receptor II (TGFBR2), but not of signal transducer and activator of transcription 3, in hADSCs showed effects similar to those of miR-21 overexpression. Downregulation of TGFBR2 and overexpression of miR21 decreased tumor vascularity. Inhibition of miR-21 and the addition of TGF-{beta} increased the levels of vascular endothelial growth factor and interleukin-6 in hADSCs. Transplantation of miR-21 inhibitor-transfected hADSCs increased blood flow recovery in a hind limb ischemia model of nude mice, compared with transplantation of control oligo-transfected cells. These findings indicate that MSCs might favor tumor growth in vivo. Thus, it is necessary to study the long-term safety of this technique before MSCs can be used as therapeutic tools in regenerative medicine and tissue engineering.

  9. Targeting miR-21 enhances the sensitivity of human colon cancer HT-29 cells to chemoradiotherapy in vitro

    SciTech Connect

    Deng, Jun; Lei, Wan; Fu, Jian-Chun; Zhang, Ling; Li, Jun-He; Xiong, Jian-Ping

    2014-01-17

    Highlight: MiR-21 plays a significant role in 5-FU resistance. This role might be attributed to targeting of hMSH2 as well as TP and DPD via miR-21 targeted hMSH2. Indirectly targeted TP and DPD to influence 5-FU chemotherapy sensitivity. -- Abstract: 5-Fluorouracil (5-FU) is a classic chemotherapeutic drug that has been widely used for colorectal cancer treatment, but colorectal cancer cells are often resistant to primary or acquired 5-FU therapy. Several studies have shown that miR-21 is significantly elevated in colorectal cancer. This suggests that this miRNA might play a role in this resistance. In this study, we investigated this possibility and the possible mechanism underlying this role. We showed that forced expression of miR-21 significantly inhibited apoptosis, enhanced cell proliferation, invasion, and colony formation ability, promoted G1/S cell cycle transition and increased the resistance of tumor cells to 5-FU and X radiation in HT-29 colon cancer cells. Furthermore, knockdown of miR-21 reversed these effects on HT-29 cells and increased the sensitivity of HT-29/5-FU to 5-FU chemotherapy. Finally, we showed that miR-21 targeted the human mutS homolog2 (hMSH2), and indirectly regulated the expression of thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD). These results demonstrate that miR-21 may play an important role in the 5-FU resistance of colon cancer cells.

  10. miR-502 inhibits cell proliferation and tumor growth in hepatocellular carcinoma through suppressing phosphoinositide 3-kinase catalytic subunit gamma

    SciTech Connect

    Chen, Suling; Li, Fang; Chai, Haiyun; Tao, Xin; Wang, Haili; Ji, Aifang

    2015-08-21

    MicroRNAs (miRNAs) play a key role in carcinogenesis and tumor progression in hepatocellular carcinoma (HCC). In the present study, we demonstrated that miR-502 significantly inhibits HCC cell proliferation in vitro and tumor growth in vivo. G1/S cell cycle arrest and apoptosis of HCC cells were induced by miR-502. Phosphoinositide 3-kinase catalytic subunit gamma (PIK3CG) was identified as a direct downstream target of miR-502 in HCC cells. Notably, overexpression of PIK3CG reversed the inhibitory effects of miR-502 in HCC cells. Our findings suggest that miR-502 functions as a tumor suppressor in HCC via inhibition of PI3KCG, supporting its utility as a promising therapeutic gene target for this tumor type. - Highlights: • miR-502 suppresses HCC cell proliferation in vitro and tumorigenicity in vivo. • miR-502 regulates cell cycle and apoptosis in HCC cells. • PIK3CG is a direct target of miR-502. • miR-502 and PIK3CG expression patterns are inversely correlated in HCC tissues.

  11. RLIP76-dependent suppression of PI3K/AKT/Bcl-2 pathway by miR-101 induces apoptosis in prostate cancer

    SciTech Connect

    Yang, Jing; Song, Qi; Cai, Yi; Wang, Peng; Wang, Min; Zhang, Dong

    2015-08-07

    MicroRNA-101 (miR-101) participates in carcinogenesis and tumor progression in various cancers. However, its biological functions in prostate cancer are still unclear. Here, we demonstrate that miR-101 represents a critical role in regulating cell apoptosis in prostate cancer cells. We first demonstrated that miR-101 treatment promoted apoptosis in DU145 and PC3 cells by using flow cytometric analysis and transmission electron microscopy (TEM). To verify the mechanisms, we identified a novel miR-101 target, Ral binding protein 1 (RLIP76). We found miR-101 transfection significantly suppresses RLIP76 expression, which can transactivate phosphorylation of PI3K-Akt signaling, and resulted in an amplification of Bcl2-induced apoptosis. Furthermore, we demonstrated that RLIP76 overexpression could reverse the anti-tumor effects of miR-101 in DU145 and PC3 cells by using flow cytometry assay and MTT assay. Taken together, our results revealed that the effect of miR-101 on prostate cancer cell apoptosis was due to RLIP76 regulation of the PI3K/Akt/Bcl-2 signaling pathway. - Highlights: • miR-101 inhibited prostate cancer cell proliferation and enhanced apoptosis. • miR-101 directly targeted and regulated RLIP76 expression. • miR-101 suppressed PI3K/Akt/Bcl-2 signaling pathway by targeting RLIP76.

  12. Cottage Lake, Washington: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    stub. You can help OpenEI by expanding it. Cottage Lake is a census-designated place in King County, Washington.1 References US Census Bureau 2005 Place to 2006 CBSA...

  13. Ames Lake, Washington: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    a stub. You can help OpenEI by expanding it. Ames Lake is a census-designated place in King County, Washington.1 References US Census Bureau 2005 Place to 2006 CBSA...

  14. Lake Marcel-Stillwater, Washington: Energy Resources | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    can help OpenEI by expanding it. Lake Marcel-Stillwater is a census-designated place in King County, Washington.1 References US Census Bureau 2005 Place to 2006 CBSA...

  15. Lake Forest Park, Washington: Energy Resources | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    article is a stub. You can help OpenEI by expanding it. Lake Forest Park is a city in King County, Washington. It falls under Washington's 1st congressional district and...

  16. Lake Morton-Berrydale, Washington: Energy Resources | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    can help OpenEI by expanding it. Lake Morton-Berrydale is a census-designated place in King County, Washington.1 References US Census Bureau 2005 Place to 2006 CBSA...

  17. Maple Heights-Lake Desire, Washington: Energy Resources | Open...

    OpenEI (Open Energy Information) [EERE & EIA]

    help OpenEI by expanding it. Maple Heights-Lake Desire is a census-designated place in King County, Washington.1 References US Census Bureau 2005 Place to 2006 CBSA...

  18. Storm Lake, Iowa: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    article is a stub. You can help OpenEI by expanding it. Storm Lake is a city in Buena Vista County, Iowa. It falls under Iowa's 5th congressional district.12 Registered...

  19. Changing Weather and Climate in the Great Lakes Region

    Energy.gov [DOE]

    This 4-week course will feature a new season each week through short lectures and activities covering Great Lakes weather, observed changes in the climate, and societal impacts of climate change....

  20. City of Lake City, Minnesota (Utility Company) | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    Place: Minnesota Phone Number: (651) 345 - 5383 (8am to 4:30pm weekdays) Website: www.ci.lake-city.mn.usindex.a Outage Hotline: After Hours: (651) 345 - 4711 or (651) 345 -...

  1. MHK Projects/Lake Huron | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    during July-August 2005 in Lake Huron. The rest of the rig was developed to mimic the action of the hydraulic system and provide the opportunity to take various measurements to...

  2. Moon Lake Electric Assn Inc (Utah) | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    search Name: Moon Lake Electric Assn Inc Place: Utah Phone Number: ALTAMONT OFFICE (435) 454-3611 -- DUCHESNE OFFICE (435) 738-5322 -- RANGELY OFFICE (970) 675-2291 --...

  3. Big Bear Lake, California: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Hide Map This article is a stub. You can help OpenEI by expanding it. Big Bear Lake is a city in San Bernardino County, California. It falls under California's...

  4. Lake Quivira, Kansas: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    This article is a stub. You can help OpenEI by expanding it. Lake Quivira is a city in Johnson County and Wyandotte County, Kansas. It falls under Kansas's 3rd congressional...

  5. Lake Meade, Pennsylvania: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    a stub. You can help OpenEI by expanding it. Lake Meade is a census-designated place in Adams County, Pennsylvania.1 References US Census Bureau 2005 Place to 2006 CBSA...

  6. Lake Heritage, Pennsylvania: Energy Resources | Open Energy Informatio...

    OpenEI (Open Energy Information) [EERE & EIA]

    You can help OpenEI by expanding it. Lake Heritage is a census-designated place in Adams County, Pennsylvania.1 References US Census Bureau 2005 Place to 2006 CBSA...

  7. Vermont Individual Lake Encroachment Permit | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Abstract Submission of this application required for notice of intent to encroach beyond the mean water level of a lake or pond, and certify that the project will comply with...

  8. Prior Lake, Minnesota: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    This article is a stub. You can help OpenEI by expanding it. Prior Lake is a city in Scott County, Minnesota. It falls under Minnesota's 2nd congressional district.12...

  9. Emerald Lake Hills, California: Energy Resources | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    Hide Map This article is a stub. You can help OpenEI by expanding it. Emerald Lake Hills is a census-designated place in San Mateo County, California.1...

  10. Medicine Lake, Minnesota: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Hide Map This article is a stub. You can help OpenEI by expanding it. Medicine Lake is a city in Hennepin County, Minnesota. It falls under Minnesota's 3rd...

  11. Blue Lake, California: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Hide Map This article is a stub. You can help OpenEI by expanding it. Blue Lake is a city in Humboldt County, California. It falls under California's 1st...

  12. Egypt Lake-Leto, Florida: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Hide Map This article is a stub. You can help OpenEI by expanding it. Egypt Lake-Leto is a census-designated place in Hillsborough County, Florida.1 References...

  13. Seven Lakes, North Carolina: Energy Resources | Open Energy Informatio...

    OpenEI (Open Energy Information) [EERE & EIA]

    stub. You can help OpenEI by expanding it. Seven Lakes is a census-designated place in Moore County, North Carolina.1 References US Census Bureau 2005 Place to 2006 CBSA...

  14. Static Temperature Survey At Lake City Hot Springs Area (Benoit...

    OpenEI (Open Energy Information) [EERE & EIA]

    Notes Two deeper wells encountered temps of 327 and 329 oF References Dick Benoit, Joe Moore, Colin Goranson, David Blackwell (2005) Core Hole Drilling And Testing At The Lake...

  15. Lake Lahontan: Geology of Southern Carson Desert, Nevada | Open...

    OpenEI (Open Energy Information) [EERE & EIA]

    with the soil of pre-Tahoe age (of Blackwelder, 1931) in the Sierra Nevada; the Churchill soil is correlated with the middle Lake Bonneville soil and with the soil of inter-Tahoe...

  16. West Lake Hills, Texas: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Hide Map This article is a stub. You can help OpenEI by expanding it. West Lake Hills is a city in Travis County, Texas. It falls under Texas's 10th congressional...

  17. Spring Lake, Michigan: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Hide Map This article is a stub. You can help OpenEI by expanding it. Spring Lake is a village in Ottawa County, Michigan. It falls under Michigan's 2nd...

  18. Spring Lake, Utah: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Hide Map This article is a stub. You can help OpenEI by expanding it. Spring Lake is a census-designated place in Utah County, Utah.1 References US Census...

  19. Red Feather Lakes, Colorado: Energy Resources | Open Energy Informatio...

    OpenEI (Open Energy Information) [EERE & EIA]

    Hide Map This article is a stub. You can help OpenEI by expanding it. Red Feather Lakes is a census-designated place in Larimer County, Colorado.1 References...

  20. Red Lake County, Minnesota: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Hide Map This article is a stub. You can help OpenEI by expanding it. Red Lake County is a county in Minnesota. Its FIPS County Code is 125. It is classified as...

  1. City of Shasta Lake Electric Utility- PV Rebate Program

    Office of Energy Efficiency and Renewable Energy (EERE)

    City of Shasta Lake Electric Utility is providing rebates to their customers for the purchase of photovoltaic (PV) systems. The rebate levels will decrease annually over the life of the program. ...

  2. Zinc deposition in acid lakes: the role of diffusion

    SciTech Connect

    Carignan, R.; Tessier, A.

    1985-06-28

    Steep negative concentration gradients of dissolved zinc are present between the overlying waters and the anoxic pore waters of two acid lakes. In the anoxic pore waters, the low zinc concentrations can be explained as due to the formation of relatively insoluble zinc sulfide minerals. Downward diffusive fluxes of dissolved zinc account for at least 50 to 75% of the recent zinc deposition to the sediments of these lakes. This downward diffusion occurs to a depth of 2 to 3 centimeters below the sediment water interface, where pronounced maxima in total zinc are observed. These subsurface peaks in total zinc have been interpreted as an indication of recent lake acidification. The present observations indicate that such subsurface peaks may also result from a diagenetic activity unrelated to recent changes in lake acidity. 22 references, 1 figure, 2 tables.

  3. Tularosa Basin Play Fairway Analysis: Pleistocene Lake Otero

    SciTech Connect

    Adam Brandt

    2015-11-15

    This submission includes a geotiff of the geographic extent of Pleistocene Lake Otero; which was used as apart of the groundwater composite risk segment in a Tularosa Basin Play Fairway Analysis.

  4. Salt Lake Community College: Solar partner with DOE | OSTI, US...

    Office of Scientific and Technical Information (OSTI)

    Salt Lake Community College: Solar partner with DOE Back to the OSTI News Listing for 2011 The DOE Rocky Mountain Solar Training Program partnership between the U.S. Department of ...

  5. Sky Lake, Florida: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Hide Map This article is a stub. You can help OpenEI by expanding it. Sky Lake is a census-designated place in Orange County, Florida.1 References US...

  6. China Lake Acres, California: Energy Resources | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    Hide Map This article is a stub. You can help OpenEI by expanding it. China Lake Acres is a census-designated place in Kern County, California.1 References ...

  7. Avon Lake, Ohio: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Hide Map This article is a stub. You can help OpenEI by expanding it. Avon Lake is a city in Lorain County, Ohio. It falls under Ohio's 13th congressional...

  8. Category:Salt Lake City, UT | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    UT Jump to: navigation, search Go Back to PV Economics By Location Media in category "Salt Lake City, UT" The following 16 files are in this category, out of 16 total....

  9. DOE - Office of Legacy Management -- Ambrosia Lake Mill Site...

    Office of Legacy Management (LM)

    Licensed to DOE for long-term custody and managed by the Office of Legacy Management ... custody and managed by the Office of Legacy Management Also see Ambrosia Lake Mill ...

  10. Lake Nacimiento, California: Energy Resources | Open Energy Informatio...

    OpenEI (Open Energy Information) [EERE & EIA]

    You can help OpenEI by expanding it. Lake Nacimiento is a census-designated place in San Luis Obispo County, California.1 References US Census Bureau 2005 Place to 2006...

  11. White Meadow Lake, New Jersey: Energy Resources | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    Hide Map This article is a stub. You can help OpenEI by expanding it. White Meadow Lake is a census-designated place in Morris County, New Jersey.1 References...

  12. MiR-20a Induces Cell Radioresistance by Activating the PTEN/PI3K/Akt Signaling Pathway in Hepatocellular Carcinoma

    SciTech Connect

    Zhang, Yuqin; Zheng, Lin; Ding, Yi; Li, Qi; Wang, Rong; Liu, Tongxin; Sun, Quanquan; Yang, Hua; Peng, Shunli; Wang, Wei; Chen, Longhua

    2015-08-01

    Purpose: To investigate the role of miR-20a in hepatocellular carcinoma (HCC) cell radioresistance, which may reveal potential strategies to improve treatment. Methods and Materials: The expression of miR-20a and PTEN were detected in HCC cell lines and paired primary tissues by quantitative real-time polymerase chain reaction. Cell radiation combined with colony formation assays was administrated to discover the effect of miR-20a on radiosensitivity. Bioinformatics prediction and luciferase assay were used to identify the target of miR-20a. The phosphatidylinositol 3-kinase inhibitor LY294002 was used to inhibit phosphorylation of Akt, to verify whether miR-20a affects HCC cell radioresistance through activating the PTEN/PI3K/Akt pathway. Results: MiR-20a levels were increased in HCC cell lines and tissues, whereas PTEN was inversely correlated with it. Overexpression of miR-20a in Bel-7402 and SMMC-7721 cells enhances their resistance to the effect of ionizing radiation, and the inhibition of miR-20a in HCCLM3 and QGY-7701 cells sensitizes them to it. PTEN was identified as a direct functional target of miR-20a for the induction of radioresistance. Overexpression of miR-20a activated the PTEN/PI3K/Akt signaling pathway. Additionally, the kinase inhibitor LY294002 could reverse the effect of miR-20a–induced radioresistance. Conclusion: MiR-20a induces HCC cell radioresistance by activating the PTEN/PI3K/Akt pathway, which suggests that miR-20a/PTEN/PI3K/Akt might represent a target of investigation for developing effective therapeutic strategies against HCC.

  13. Thermokarst lake methanogenesis along a complete talik profile

    DOE PAGES [OSTI]

    Heslop, J. K.; Walter Anthony, K. M.; Sepulveda-Jauregui, A.; Martinez-Cruz, K.; Bondurant, A.; Grosse, G.; Jones, M. C.

    2015-07-24

    Thermokarst (thaw) lakes emit methane (CH4) to the atmosphere formed from thawed permafrost organic matter (OM), but the relative magnitude of CH4 production in surface lake sediments vs. deeper thawed permafrost horizons is not well understood. We assessed anaerobic CH4 production potentials from various depths along a 590 cm long lake sediment core that captured the entire sediment package of the talik (thaw bulb) beneath the center of an interior Alaska thermokarst lake, Vault Lake, and the top 40 cm of thawing permafrost beneath the talik. We also studied the adjacent Vault Creek permafrost tunnel that extends through ice-rich yedomamore » permafrost soils surrounding the lake and into underlying gravel. Our results showed CH4 production potentials were highest in the organic-rich surface lake sediments, which were 151 cm thick (mean ± SD: 5.95 ± 1.67 μg C–CH4 g dw-1 d-1; 125.9 ± 36.2 μg C–CH4 g C−1org d-1). High CH4 production potentials were also observed in recently thawed permafrost (1.18 ± 0.61 μg C–CH4g dw-1 d-1; 59.60± 51.5 μg C–CH4 g C−1org d-1) at the bottom of the talik, but the narrow thicknesses (43 cm) of this horizon limited its overall contribution to total sediment column CH4 production in the core. Lower rates of CH4 production were observed in sediment horizons representing permafrost that has been thawing in the talik for a longer period of time. No CH4 production was observed in samples obtained from the permafrost tunnel, a non-lake environment. Our findings imply that CH4 production is highly variable in thermokarst lake systems and that both modern OM supplied to surface sediments and ancient OM supplied to both surface and deep lake sediments by in situ thaw and shore erosion of yedoma permafrost are important to lake CH4 production.« less

  14. Thermokarst-lake methanogenesis along a complete talik profile

    DOE PAGES [OSTI]

    Heslop, J. K.; Walter Anthony, K. M.; Sepulveda-Jauregui, A.; Martinez-Cruz, K.; Bondurant, A.; Grosse, G.; Jones, M. C.

    2015-03-24

    Thermokarst (thaw) lakes emit methane (CH4) to the atmosphere formed from thawed permafrost organic matter (OM), but the relative magnitude of CH4 production in surface lake sediments vs. deeper thawed permafrost horizons is not well understood. We assessed anaerobic CH4 production potentials from various depths along a 590 cm long lake sediment core that captured the entire sediment package of the talik (thaw bulb) beneath the center of an interior Alaska thermokarst lake, Vault Lake, and the top 40 cm of thawing permafrost beneath the talik. We also studied the adjacent Vault Creek permafrost tunnel that extends through ice-rich yedomamore » permafrost soils surrounding the lake and into underlying gravel. Our results showed CH4 production potentials were highest in the organic-rich surface lake sediments, which were 151 cm thick (mean ± SD 5.95 ± 1.67 μg C-CH4 g dw-1 d-1; 125.9± 36.2 μg C-CH4 g C-1org d-1). High CH4 production potentials were also observed in recently-thawed permafrost (1.18± 0.61 μg C-CH4g dw-1 d-1; 59.60± 51.5 μg C-CH4 g C-1org d-1) at the bottom of the talik, but the narrow thicknesses (43 cm) of this horizon limited its overall contribution to total sediment column CH4 production in the core. Lower rates of CH4 production were observed in sediment horizons representing permafrost that has been thawed in the talik for longer periods of time. No CH4 production was observed in samples obtained from the permafrost tunnel, a non-lake environment. Our findings imply that CH4 production is highly variable in thermokarst-lake systems and that both modern OM supplied to surface sediments and ancient OM supplied to both surface and deep lake sediments by in situ thaw as well as shore erosion of yedoma permafrost are important to lake CH4 production.« less

  15. Klamath and Lake Counties Agricultural Industrial Park; 2010 Geothermal

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Technology Program Peer Review Report | Department of Energy Park; 2010 Geothermal Technology Program Peer Review Report Klamath and Lake Counties Agricultural Industrial Park; 2010 Geothermal Technology Program Peer Review Report DOE 2010 Geothermal Technologies Program Peer Review lowtemp_013_riley.pdf (222.49 KB) More Documents & Publications Microseismic Study with LBNL - Monitoring the Effect of Injection of Fluids from the Lake County Pipeline on Seismicity at The Geysers,

  16. Lake Erie Connector Project Envrionmental Assessment Appendix Draft

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Volume II-Appendices U.S. Department of Energy Office of Electricity Delivery and Energy Reliability Washington DC June 2016 Cover Photo Credits http://www.itclakeerieconnector.com/ DRAFT LAKE ERIE CONNECTOR PROJECT ENVIRONMENTAL ASSESSMENT Volume II Appendices DOE/EA-2019 U.S. DEPARTMENT OF ENERGY OFFICE OF ELECTRICITY DELIVERY AND ENERGY RELIABILITY COOPERATING AGENCY U.S. ARMY CORPS OF ENGINEERS This Page Intentionally Left Blank Lake Erie Connector Project Draft Environmental Assessment

  17. EIS-0491: Lake Charles Liquefaction Project; Calcasieu Parish, Louisiana |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy 1: Lake Charles Liquefaction Project; Calcasieu Parish, Louisiana EIS-0491: Lake Charles Liquefaction Project; Calcasieu Parish, Louisiana Summary The Federal Energy Regulatory Commission (FERC) prepared an EIS that assesses the potential environmental impacts in the states of Arkansas, Mississippi, and Louisiana, of a proposal 1) to expand an existing liquefied natural gas (LNG) import terminal in Calcasieu Parish, Louisiana, by constructing and operating natural gas

  18. EIS-0498: Magnolia LNG and Lake Charles Expansion Projects; Calcasieu

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Parish, Louisiana | Department of Energy 8: Magnolia LNG and Lake Charles Expansion Projects; Calcasieu Parish, Louisiana EIS-0498: Magnolia LNG and Lake Charles Expansion Projects; Calcasieu Parish, Louisiana Summary The Federal Energy Regulatory Commission (FERC) prepared an EIS that assesses the potential environmental impacts of a proposal to construct and operate 1) liquefied natural gas (LNG) facilities to treat, liquefy, store, and load (LNG) onto LNG carriers, barges, and trucks for

  19. Energy Department Supports Efficiency Upgrades in Alaska's Lake and

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Peninsula Borough | Department of Energy Supports Efficiency Upgrades in Alaska's Lake and Peninsula Borough Energy Department Supports Efficiency Upgrades in Alaska's Lake and Peninsula Borough March 24, 2016 - 4:48pm Addthis Insulation is a key element of weatherization because it provides resistance to heat flow which lowers a family’s heating and cooling costs. Insulation is especially important for homes in arctic climates, like this home in Alaska. The Energy Department's

  20. EIS-0099: Remedial Actions at the Former Vitro Chemical Company Site, South Salt Lake, Salt Lake County, Utah

    Energy.gov [DOE]

    The U.S. Department of Energy developed this statement to evaluate the environmental impacts of various scenarios associated with the cleanup of those residues remaining at the abandoned uranium mill tailings site located in South Salt Lake, Utah.

  1. NY); Logvenov, Gennady (Port Jefferson Station, NY); Gozar, Adrian...

    Office of Scientific and Technical Information (OSTI)

    50 K and this enhanced superconductivity is also shown to originate from a 1 to 2 unit cell thick interfacial layer. The results demonstrate that engineering artificial...

  2. DOE - Office of Legacy Management -- New York, NY, Site - NY...

    Office of Legacy Management (LM)

    FACT SHEET This fact sheet provides information about the New York, New York, Site. This site is managed by the U.S. Department of Energy Office of Legacy Management. Aerial ...

  3. MiR-145 is downregulated in human ovarian cancer and modulates cell growth and invasion by targeting p70S6K1 and MUC1

    SciTech Connect

    Wu, Huijuan; Xiao, ZhengHua; Wang, Ke; Liu, Wenxin; Hao, Quan

    2013-11-29

    Highlights: •MiR-145 is downregulated in human ovarian cancer. •MiR-145 targets p70S6K1 and MUC1. •p70S6K1 and MUC1 are involved in miR-145 mediated tumor cell growth and cell invasion, respectively. -- Abstract: MicroRNAs (miRNAs) are a family of small non-coding RNA molecules that regulate gene expression at post-transcriptional levels. Previous studies have shown that miR-145 is downregulated in human ovarian cancer; however, the roles of miR-145 in ovarian cancer growth and invasion have not been fully demonstrated. In the present study, Northern blot and qRT-PCR analysis indicate that miR-145 is downregulated in ovarian cancer tissues and cell lines, as well as in serum samples of ovarian cancer, compared to healthy ovarian tissues, cell lines and serum samples. Functional studies suggest that miR-145 overexpression leads to the inhibition of colony formation, cell proliferation, cell growth viability and invasion, and the induction of cell apoptosis. In accordance with the effect of miR-145 on cell growth, miR-145 suppresses tumor growth in vivo. MiR-145 is found to negatively regulate P70S6K1 and MUC1 protein levels by directly targeting their 3′UTRs. Importantly, the overexpression of p70S6K1 and MUC1 can restore the cell colony formation and invasion abilities that are reduced by miR-145, respectively. MiR-145 expression is increased after 5-aza-CdR treatment, and 5-aza-CdR treatment results in the same phenotype as the effect of miR-145 overexpression. Our study suggests that miR-145 modulates ovarian cancer growth and invasion by suppressing p70S6K1 and MUC1, functioning as a tumor suppressor. Moreover, our data imply that miR-145 has potential as a miRNA-based therapeutic target for ovarian cancer.

  4. NY_10-13.pdf

    Office of Legacy Management (LM)

  5. NY_17-18.pdf

    Office of Legacy Management (LM)

  6. NY.O-20- I

    Office of Legacy Management (LM)

    Ol-e Refined Source Material Residue Natural. Radioactive Material from Non-Nuclear Man-Made I Facility was Licensed During AECMED-Related Operations For Simil.ar Activities...

  7. ZERH Training Session: Syracuse, NY

    Energy.gov [DOE]

    The DOE Zero Energy Ready Home is a high performance home which is so energy efficient, that a renewable energy system can offset all or most of its annual energy Consumption.US DOE Zero Energy...

  8. The long non-coding RNA H19-derived miR-675 modulates human gastric cancer cell proliferation by targeting tumor suppressor RUNX1

    SciTech Connect

    Zhuang, Ming; Gao, Wen; Xu, Jing; Wang, Ping; Shu, Yongqian

    2014-06-06

    Graphical abstract: - Highlights: • H19 regulates gastric cancer cell proliferation phenotype via miR-675. • MiR-675 modulates cell proliferation of gastric cancer cells by targeting tumor suppressor RUNX1. • The H19/miR-675/RUNX1 axis plays an important role in the tumorigenesis of gastric cancer. - Abstract: The lncRNA H19 has been recently shown to be upregulated and play important roles in gastric cancer tumorigenesis. However, the precise molecular mechanism of H19 and its mature product miR-675 in the carcinogenesis of gastric cancer remains unclear. In this study, we found that miR-675 was positively expressed with H19 and was a pivotal mediator in H19-induced gastric cancer cell growth promotion. Subsequently, the tumor suppressor Runt Domain Transcription Factor1 (RUNX1) was confirmed to be a direct target of miR-675 using a luciferase reporter assay and Western blotting analyses. A series of rescue assays indicated that RUNX1 mediated H19/miR-67-induced gastric cancer cell phenotypic changes. Moreover, the inverse relationship between the expression of RUNX1 and H19/miR-675 was also revealed in gastric cancer tissues and gastric cancer cell lines. Taken together, our study demonstrated that the novel pathway H19/miR-675/RUNX1 regulates gastric cancer development and may serve as a potential target for gastric cancer therapy.

  9. Wellhead monitors automate Lake Maracaibo gas lift

    SciTech Connect

    Adjunta, J.C. ); Majek, A. )

    1994-11-28

    High-performance personal computer (PC) and intelligent remote terminal unit (IRTU) technology have optimized the remote control of gas lift injection and surveillance of over 1,000 offshore production wells at Lake Maracaibo in Venezuela. In its 3-year program, Maraven expects a 27,000 b/d increase in oil production by reducing deferred production and optimizing gas lift injection by as much as 20%. In addition, real time data on well performance will enhance production management as well as allocation of operational and maintenance resources. The remote control system consists of a solar-powered wellhead monitor (WHM) installed on each well platform. At each flow gathering station within a 2-mile range of a family of wells, a host terminal unit polls and stores the well data with low power, 250-mw radios. From a remote location, 60 miles onshore, an operator interface polls the host units for real time data with 5-watt radios operating in the 900-megahertz band. The paper describes the design, optimization, telemetry management, and selection of a single vendor for this system. The economic impact of this system to Maraven is also discussed.

  10. Testing CPT conservation using the NuMI neutrino beam with the MINOS experiment

    SciTech Connect

    Auty, David John

    2010-05-01

    The MINOS experiment was designed to measure neutrino oscillation parameters with muon neutrinos. It achieves this by measuring the neutrino energy spectrum and flavor composition of the man-made NuMI neutrino beam 1km after the beam is formed and again after 735 km. By comparing the two spectra it is possible to measure the oscillation parameters. The NuMI beam is made up of 7.0% {bar {nu}}{sub {mu}}, which can be separated from the {nu}{sub {mu}} because the MINOS detectors are magnetized. This makes it possible to study {bar {nu}}{sub {mu}} oscillations separately from those of muon neutrinos, and thereby test CPT invariance in the neutrino sector by determining the {bar {nu}}{sub {mu}} oscillation parameters and comparing them with those for {nu}{sub {mu}}, although any unknown physics of the antineutrino would appear as a difference in oscillation parameters. Such a test has not been performed with beam {bar {nu}}{sub {mu}} before. It is also possible to produce an almost pure {bar {nu}}{sub {mu}} beam by reversing the current through the magnetic focusing horns of the NuMI beamline, thereby focusing negatively, instead of positively charged particles. This thesis describes the analysis of the 7% {bar {nu}}{sub {mu}} component of the forward horn current NuMI beam. The {bar {nu}}{sub {mu}} of a data sample of 3.2 x 10{sup 20} protons on target analysis found 42 events, compared to a CPT conserving prediction of 58.3{sub -7.6}{sup +7.6}(stat.){sub -3.6}{sup +3.6}(syst.) events. This corresponds to a 1.9 {sigma} deficit, and a best fit value of {Delta}{bar m}{sub 32}{sup 2} = 18 x 10{sup -3} eV{sup 2} and sin{sup 2} 2{bar {theta}}{sub 23} = 0.55. This thesis focuses particularly on the selection of {bar {nu}}{sub {mu}} events, and investigates possible improvements of the selection algorithm. From this a different selector was chosen, which corroborated the findings of the original selector. The thesis also investigates how the systematic errors affect the

  11. ,"Detroit, MI Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Detroit, MI Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  12. ,"Marysville, MI Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Marysville, MI Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  13. Port Huron, MI Natural Gas Pipeline Imports From Canada (Dollars per

    Energy Information Administration (EIA) (indexed site)

    Thousand Cubic Feet) Dollars per Thousand Cubic Feet) Port Huron, MI Natural Gas Pipeline Imports From Canada (Dollars per Thousand Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2016 2.07 2.06 2.21 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Price of

  14. ,"St. Clair, MI Natural Gas Pipeline Exports to Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Exports to Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","St. Clair, MI Natural Gas Pipeline Exports to Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  15. ,"St. Clair, MI Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","St. Clair, MI Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  16. Other Participants 2003 | U.S. DOE Office of Science (SC)

    Office of Science (SC)

    ... , Pullman , WA 51. Randolph School , Huntsville , AL 52. Renaissance High School , Detroit , MI 53. Saratoga Springs High School , Saratoga Springs , NY 54. Sault Area High School ...

  17. State Energy Data System CSV File Documentation Price and Expenditure...

    Gasoline and Diesel Fuel Update

    ... DE Delaware ME Maine NY New York WA Washington FL Florida MI Michigan OH Ohio WI Wisconsin ... SOCCB Commercial photovoltaic and solar thermal energy consumption (excluding ...

  18. Obama Administration Announces $20 Million for 10 Public-Private Partnerships to Support American Manufacturing and Encourage Investment in the U.S.

    Energy.gov [DOE]

    Investments will promote job creation and economic growth in local industry clusters in AZ, CA, MI, NY, OK, OR, PA, TN AND WA

  19. Mr. Shaun Maloney :

    Office of Legacy Management (LM)

    ... Detroit, MI 48232 Chambersburg Engineering Co. Chambersburg, PA Ithaca Gun Co. Ithaca, NY New England Materials Lab., Inc. Teledyne Materials' . Medford, MA NRC Equipment Co. . -. ...

  20. AN ESTIMATE OF THE CHEMICAL COMPOSITION OF TITAN's LAKES

    SciTech Connect

    Cordier, Daniel; Mousis, Olivier; Lunine, Jonathan I.; Lavvas, Panayotis; Vuitton, Veronique

    2009-12-20

    Hundreds of radar-dark patches interpreted as lakes have been discovered in the north and south polar regions of Titan. We have estimated the composition of these lakes by using the direct abundance measurements from the Gas Chromatograph Mass Spectrometer aboard the Huygens probe and recent photochemical models based on the vertical temperature profile derived by the Huygens Atmospheric Structure Instrument. Thermodynamic equilibrium is assumed between the atmosphere and the lakes, which are also considered nonideal solutions. We find that the main constituents of the lakes are ethane (C{sub 2}H{sub 6}) (approx76%-79%), propane (C{sub 3}H{sub 8}) (approx7%-8%), methane (CH{sub 4}) (approx5%-10%), hydrogen cyanide (HCN) (approx2%-3%), butene (C{sub 4}H{sub 8}) (approx1%), butane (C{sub 4}H{sub 10}) (approx1%), and acetylene (C{sub 2}H{sub 2}) (approx1%). The calculated composition of lakes is then substantially different from what has been expected from models elaborated prior to the exploration of Titan by the Cassini-Huygens spacecraft.

  1. AERIAL MEASUREMENTS OF CONVECTION CELL ELEMENTS IN HEATED LAKES

    SciTech Connect

    Villa-Aleman, E; Saleem Salaymeh, S; Timothy Brown, T; Alfred Garrett, A; Malcolm Pendergast, M; Linda Nichols, L

    2007-12-19

    Power plant-heated lakes are characterized by a temperature gradient in the thermal plume originating at the discharge of the power plant and terminating at the water intake. The maximum water temperature discharged by the power plant into the lake depends on the power generated at the facility and environmental regulations on the temperature of the lake. Besides the observed thermal plume, cloud-like thermal cells (convection cell elements) are also observed on the water surface. The size, shape and temperature of the convection cell elements depends on several parameters such as the lake water temperature, wind speed, surfactants and the depth of the thermocline. The Savannah River National Laboratory (SRNL) and Clemson University are collaborating to determine the applicability of laboratory empirical correlations between surface heat flux and thermal convection intensity. Laboratory experiments at Clemson University have demonstrated a simple relationship between the surface heat flux and the standard deviation of temperature fluctuations. Similar results were observed in the aerial thermal imagery SRNL collected at different locations along the thermal plume and at different elevations. SRNL will present evidence that the results at Clemson University are applicable to cooling lakes.

  2. DOE Tour of Zero Floorplans: Mutual Housing at Spring Lake by...

    Energy Saver

    DOE Tour of Zero Floorplans: Mutual Housing at Spring Lake by Mutual Housing California DOE Tour of Zero Floorplans: Mutual Housing at Spring Lake by Mutual Housing California DOE ...

  3. Soda Lake Well Lithology Data and Geologic Cross-Sections (Dataset...

    Office of Scientific and Technical Information (OSTI)

    Soda Lake Well Lithology Data and Geologic Cross-Sections Title: Soda Lake Well Lithology Data and Geologic Cross-Sections Comprehensive catalogue of drill-hole data in ...

  4. SEMI-ANNUAL REPORTS FOR LAKE CHARLES LNG EXPORT COMPANY, LLC...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    LAKE CHARLES LNG EXPORT COMPANY, LLC (formerly Trunkline LNG Export, LLC) - DK. NO. 13-04-LNG - ORDER 3252 SEMI-ANNUAL REPORTS FOR LAKE CHARLES LNG EXPORT COMPANY, LLC (formerly ...

  5. Price of Lake Charles, LA Natural Gas LNG Imports from Qatar...

    Gasoline and Diesel Fuel Update

    Qatar (Dollars per Thousand Cubic Feet) Price of Lake Charles, LA Natural Gas LNG Imports ... U.S. Price of Liquefied Natural Gas Imports by Point of Entry Lake Charles, LA LNG Imports ...

  6. Price of Lake Charles, LA Natural Gas LNG Imports from Egypt...

    Gasoline and Diesel Fuel Update

    Egypt (Nominal Dollars per Thousand Cubic Feet) Price of Lake Charles, LA Natural Gas LNG ... U.S. Price of Liquefied Natural Gas Imports by Point of Entry Lake Charles, LA LNG Imports ...

  7. Price of Lake Charles, LA Natural Gas LNG Imports from Nigeria...

    Gasoline and Diesel Fuel Update

    Nigeria (Dollars per Thousand Cubic Feet) Price of Lake Charles, LA Natural Gas LNG ... U.S. Price of Liquefied Natural Gas Imports by Point of Entry Lake Charles, LA LNG Imports ...

  8. Price of Lake Charles, LA Natural Gas LNG Imports from Oman ...

    Energy Information Administration (EIA) (indexed site)

    Oman (Dollars per Thousand Cubic Feet) Price of Lake Charles, LA Natural Gas LNG Imports ... U.S. Price of Liquefied Natural Gas Imports by Point of Entry Lake Charles, LA LNG Imports ...

  9. Price of Lake Charles, LA Natural Gas LNG Imports from Australia...

    Energy Information Administration (EIA) (indexed site)

    Australia (Dollars per Thousand Cubic Feet) Price of Lake Charles, LA Natural Gas LNG ... U.S. Price of Liquefied Natural Gas Imports by Point of Entry Lake Charles, LA LNG Imports ...

  10. Price of Lake Charles, LA Natural Gas LNG Imports from Malaysia...

    Gasoline and Diesel Fuel Update

    Malaysia (Dollars per Thousand Cubic Feet) Price of Lake Charles, LA Natural Gas LNG ... U.S. Price of Liquefied Natural Gas Imports by Point of Entry Lake Charles, LA LNG Imports ...

  11. Price of Lake Charles, LA Natural Gas LNG Imports from United...

    Annual Energy Outlook

    Price of Lake Charles, LA Natural Gas LNG Imports from United Arab Emirates (Dollars per ... U.S. Price of Liquefied Natural Gas Imports by Point of Entry Lake Charles, LA LNG Imports ...

  12. Price of Lake Charles, LA Natural Gas LNG Imports from Indonesia...

    Energy Information Administration (EIA) (indexed site)

    Indonesia (Dollars per Thousand Cubic Feet) Price of Lake Charles, LA Natural Gas LNG ... U.S. Price of Liquefied Natural Gas Imports by Point of Entry Lake Charles, LA LNG Imports ...

  13. Price of Lake Charles, LA Natural Gas LNG Imports from Other...

    Energy Information Administration (EIA) (indexed site)

    Price of Lake Charles, LA Natural Gas LNG Imports from Other Countries (Nominal Dollars ... U.S. Price of Liquefied Natural Gas Imports by Point of Entry Lake Charles, LA LNG Imports ...

  14. Price of Lake Charles, LA Natural Gas LNG Imports from Algeria...

    Annual Energy Outlook

    Algeria (Dollars per Thousand Cubic Feet) Price of Lake Charles, LA Natural Gas LNG ... U.S. Price of Liquefied Natural Gas Imports by Point of Entry Lake Charles, LA LNG Imports ...

  15. Price of Lake Charles, LA Natural Gas LNG Imports from Brunei...

    Annual Energy Outlook

    Brunei (Dollars per Thousand Cubic Feet) Price of Lake Charles, LA Natural Gas LNG Imports ... U.S. Price of Liquefied Natural Gas Imports by Point of Entry Lake Charles, LA LNG Imports ...

  16. Borehole Imaging of In Situ Stress Tests at Mirror Lake Research...

    OpenEI (Open Energy Information) [EERE & EIA]

    at Mirror Lake Research Site Citation U.S. Geological Survey. Borehole Imaging of In Situ Stress Tests at Mirror Lake Research Site Internet. 2013. U.S. Geological Survey. cited...

  17. DOE Tour of Zero: Mutual Housing at Spring Lake by Mutual Housing...

    Energy Saver

    Mutual Housing at Spring Lake by Mutual Housing California DOE Tour of Zero: Mutual Housing at Spring Lake by Mutual Housing California 1 of 14 Mutual Housing built this 62-unit ...

  18. SEMI-ANNUAL REPORTS FOR LAKE CHARLES EXPORTS, LLC - FE DKT. NO...

    Energy Saver

    LAKE CHARLES EXPORTS, LLC - FE DKT. NO. 11-59-LNG - ORDER 3324 SEMI-ANNUAL REPORTS FOR LAKE CHARLES EXPORTS, LLC - FE DKT. NO. 11-59-LNG - ORDER 3324 PDF icon October 2013 PDF icon ...

  19. Assessment of radiological releases from the NuMI facility during MINOS and NOvA operations

    SciTech Connect

    Martens, Mike; /Fermilab

    2007-04-01

    This report makes projections of the radiological releases from the NuMI facility during operations for the MINOS and NO ?A experiments. It includes an estimate of the radionuclide levels released into the atmosphere and the estimated tritium and sodium-22 concentrations in the NuMI sump water and Fermilab pond system. The analysis was performed for NuMI operations with a beam power on target increased from the present 400 kW design up to a possible 1500 kW with future upgrades. The total number of protons on target was assumed to be 18 x 10{sup 20} after the completion of MINOS and 78 x 10{sup 20} after the completion of NO ?A.

  20. Identification of miR-2400 gene as a novel regulator in skeletal muscle satellite cells proliferation by targeting MYOG gene

    SciTech Connect

    Zhang, Wei Wei; Tong, Hui Li; Sun, Xiao Feng; Hu, Qian; Yang, Yu; Li, Shu Feng; Yan, Yun Qin; Li, Guang Peng

    2015-08-07

    MicroRNAs play critical roles in skeletal muscle development as well as in regulation of muscle cell proliferation and differentiation. Previous study in our laboratory showed that the expression level of miR-2400, a novel and unique miRNA from bovine, had significantly changed in skeletal muscle-derived satellite cells (MDSCs) during differentiation, however, the function and expression pattern for miR-2400 in MDSCs has not been fully understood. In this report, we firstly identified that the expression levels of miR-2400 were down-regulated during MDSCs differentiation by stem-loop RT-PCR. Over-expression and inhibition studies demonstrated that miR-2400 promoted MDSCs proliferation by EdU (5-ethynyl-2′ deoxyuridine) incorporation assay and immunofluorescence staining of Proliferating cell nuclear antigen (PCNA). Luciferase reporter assays showed that miR-2400 directly targeted the 3′ untranslated regions (UTRs) of myogenin (MYOG) mRNA. These data suggested that miR-2400 could promote MDSCs proliferation through targeting MYOG. Furthermore, we found that miR-2400, which was located within the eighth intron of the Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) gene, was down-regulated in MDSCs in a direct correlation with the WHSC1L1 transcript by Clustered regularly interspaced palindromic repeats interference (CRISPRi). In addition, these observations not only provided supporting evidence for the codependent expression of intronic miRNAs and their host genes in vitro, but also gave insight into the role of miR-2400 in MDSCs proliferation. - Highlights: • miR-2400 is a novel and unique miRNA from bovine. • miR-2400 could promote skeletal muscle satellite cells proliferation. • miR-2400 directly targeted the 3′ untranslated regions of MYOG mRNA. • miR-2400 could be coexpressed together with its host gene WHSC1L1.

  1. Application for Presidential Permit OE Docket No. PP-412 ITC Lake Erie

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Connector Project | Department of Energy Project Application for Presidential Permit OE Docket No. PP-412 ITC Lake Erie Connector Project Application from ITC Lake Erie to construct, operate and maintain electric transmission facilities at the U.S. - Canada Border. PP-412 Lake Erie Application.pdf (2.82 MB) More Documents & Publications Application for Presidential Permit OE Docket No. PP-412 ITC Lake Erie Connector Project: Federal Register Notice, Volume 80, No. 137 - July 17, 2015

  2. miR-340 inhibits glioblastoma cell proliferation by suppressing CDK6, cyclin-D1 and cyclin-D2

    SciTech Connect

    Li, Xuesong; Gong, Xuhai; Chen, Jing; Zhang, Jinghui; Sun, Jiahang; Guo, Mian

    2015-05-08

    Glioblastoma development is often associated with alteration in the activity and expression of cell cycle regulators, such as cyclin-dependent kinases (CKDs) and cyclins, resulting in aberrant cell proliferation. Recent studies have highlighted the pivotal roles of miRNAs in controlling the development and growth of glioblastoma. Here, we provide evidence for a function of miR-340 in the inhibition of glioblastoma cell proliferation. We found that miR-340 is downregulated in human glioblastoma tissue samples and several established glioblastoma cell lines. Proliferation and neurosphere formation assays revealed that miR-340 plays an oncosuppressive role in glioblastoma, and that its ectopic expression causes significant defect in glioblastoma cell growth. Further, using bioinformatics, luciferase assay and western blot, we found that miR-340 specifically targets the 3′UTRs of CDK6, cyclin-D1 and cyclin-D2, leading to the arrest of glioblastoma cells in the G0/G1 cell cycle phase. Confirming these results, we found that re-introducing CDK6, cyclin-D1 or cyclin-D2 expression partially, but significantly, rescues cells from the suppression of cell proliferation and cell cycle arrest mediated by miR-340. Collectively, our results demonstrate that miR-340 plays a tumor-suppressive role in glioblastoma and may be useful as a diagnostic biomarker and/or a therapeutic avenue for glioblastoma. - Highlights: • miR-340 is downregulated in glioblastoma samples and cell lines. • miR-340 inhibits glioblastoma cell proliferation. • miR-340 directly targets CDK6, cyclin-D1, and cyclin-D2. • miR-340 regulates glioblastoma cell proliferation via CDK6, cyclin-D1 and cyclin-D2.

  3. Uranium distribution in relation to sedimentary facies, Kern Lake, California

    SciTech Connect

    Merifield, P.M.; Carlisle, D.; Idiz, E.; Anderhalt, R.; Reed, W.E.; Lamar, D.L.

    1980-04-01

    Kern Lake has served as a sink for drainage from the southern Sierra Nevada and, in lesser amounts, from the southern Temblor Range. Both areas contain significant uranium source rocks. The uranium content in Holocene Kern Lake sediments correlates best with the mud (silt and clay) fraction. It correlates less well with organic carbon. Biotite grains could account for much of the uranium in the sand fraction, and perhaps the silt fraction as well. The data suggest that fixation of uranium by adsorption on mineral grains is a dominant process in this lake system. Further work is required to determine the importance of cation-exchange of uranium on clays and micas and of organically complexed uranium adsorbed to mineral surfaces. These findings also raise the question of whether uranium transport down the Kern River occurs largely as uranium adsorbed to mineral surfaces.

  4. ,"Sault St Marie, MI Natural Gas Pipeline Exports to Canada (Million Cubic Feet)"

    Energy Information Administration (EIA) (indexed site)

    Sault St Marie, MI Natural Gas Pipeline Exports to Canada (Million Cubic Feet)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Sault St Marie, MI Natural Gas Pipeline Exports to Canada (Million Cubic Feet)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release

  5. miR-206 is down-regulated in breast cancer and inhibits cell proliferation through the up-regulation of cyclinD2

    SciTech Connect

    Zhou, Jing; Tian, Ye; Li, Juan; Lu, Binbin; Sun, Ming; Zou, Yanfen; Kong, Rong; Luo, Yanhong; Shi, Yongguo; Wang, Keming; Ji, Guozhong

    2013-04-05

    Highlights: ? miR-206 was downexpressed in tumor samples compared with matched normal samples. ? Enhanced expression of miR-206 could inhibit breast cancer growth in vitro. ? Luciferase confirmed miR-206 functions as an anti-oncogene by targeting cyclinD2. ? A reverse correlation between miR-206 and cyclinD2 in breast cancer was found. -- Abstract: MicroRNAs act as important gene regulators in human genomes, and their aberrant expression is linked to many malignancies. Aberrant expression of miR-206 has been frequently reported in cancer studies; however, the role and mechanism of its function in breast cancer remains unclear. Quantitative real-time PCR was performed to detect the relative expression levels of miR-206 in breast cancer and normal breast tissues. Lower expression of miR-206 in breast cancer tissues was associated with larger tumour size and a more advanced clinical stage. Further in vitro observations showed that the enforced expression of miR-206 in MCF-7 breast cancer cells inhibited cell growth by blocking the G1/S transition and suppressed cell proliferation and colony formation, implying that miR-206 functions as a tumour suppressor in the progression of breast cancer. Interestingly, Luciferase assays first revealed that miR-206 inhibited cyclinD2 expression by targeting two binding sites in the 3?-untranslated region of cyclinD2 mRNA. qRT-PCR and Western blot assays verified that miR-206 reduced cyclinD2 expression at both the mRNA and protein levels. A reverse correlation between miR-206 and cyclinD2 expression was noted in breast cancer tissues. Altogether, our results identify a crucial tumour suppressive role of miR-206 in the progression of breast cancer, at least partly via up-regulation of the expression of cyclinD2, and suggest that miR-206 might be a candidate prognostic predictor or an anticancer therapeutic target for breast cancer patients.

  6. MiR-138 promotes smooth muscle cells proliferation and migration in db/db mice through down-regulation of SIRT1

    SciTech Connect

    Xu, Juan; Li, Li; Yun, Hui-fang; Han, Ye-shan

    2015-08-07

    Background: Diabetic vascular smooth muscle cells (VSMCs) exhibit significantly increased rates of proliferation and migration, which was the most common pathological change in atherosclerosis. In addition, the study about the role for miRNAs in the regulation of VSMC proliferation is just beginning to emerge and additional miRNAs involved in VSMC proliferation modulation should be identified. Methods: The expression of miR-138 and SIRT1 were examined in SMCs separated from db/db mice and in SMC lines C-12511 exposed to high glucose with qRT-PCR and western blot. The regulation of miR-138 on the expression of SMCs was detected with luciferase report assay. VSMCs proliferation and migration assays were performed to examine the effect of miR-138 inhibitor on VSMCs proliferation and migration. Results: We discovered that higher mRNA level of miR-138 and reduced expression of SIRT1 were observed in SMCs separated from db/db mice and in SMC lines C-12511. Moreover, luciferase report assay showed that the activity of SIRT1 3′-UTR was highly increased by miR-138 inhibitor and reduced by miR-138 mimic. In addition, we examined that the up-regulation of NF-κB induced by high glucose in SMCs was reversed by resveratrol and miR-138 inhibitor. MTT and migration assays showed that miR-138 inhibitor attenuated the proliferation and migration of smooth muscle cells. Conclusion: In this study, we revealed that miR-138 might promote proliferation and migration of SMC in db/db mice through suppressing the expression of SIRT1. - Highlights: • Higher mRNA level of miR-138 was observed in SMCs from db/db mice. • The mRNA and protein level of SIRT1 in SMCs from db/db mice were greatly reduced. • miR-138 could regulate the expression of SIRT1 in SMCs. • SIRT1 overexpression reversed the up-regulation of acetylized p65 and NF-κB induced by high glucose. • MiR-138 inhibitor reversed VSMCs proliferation and migration induced by high glucose.

  7. Lake Roosevelt Fisheries Evaluation Program, Part B; Limnology, Primary Production, and Zooplankton in Lake Roosevelt, Washington, 1998 Annual Report.

    SciTech Connect

    Shields, John; Spotts, Jim; Underwood, Keith

    2002-11-01

    The Lake Roosevelt Fisheries Evaluation Program is the result of a merger between two projects, the Lake Roosevelt Monitoring Program (BPA No. 8806300) and the Lake Roosevelt Data Collection Project (BPA No. 9404300). These projects were merged in 1996 to continue work historically completed under the separate projects, and is now referred to as the Lake Roosevelt Fisheries Evaluation Program. The 1998 Annual Report, Part B. Limnology, Primary Production, and Zooplankton in Lake Roosevelt, Washington examined the limnology, primary production, and zooplankton at eleven locations throughout the reservoir. The 1998 research protocol required a continuation of the more complete examination of limnological parameters in Lake Roosevelt that began in 1997. Phytoplankton and periphyton speciation, phytoplankton and periphyton chlorophyll a analysis, complete zooplankton biomass analysis by taxonomic group, and an increased number of limnologic parameters (TDG, TDS, etc.) were examined and compared with 1997 results. Total dissolved gas levels were greatly reduced in 1998, compared with 1997, likely resulting from the relatively normal water year experienced in 1998. Mean water temperatures were similar to what was observed in past years, with a maximum of 22.7 C and a minimum of 2.6 C. Oxygen concentrations were also relatively normal, with a maximum of 16.6 mg/L, and a minimum of 0.9 mg/L. Phytoplankton in Lake Roosevelt was primarily composed of microplankton (29.6%), Cryptophyceae (21.7%), and Bacillriophyceae (17.0 %). Mean total phytoplankton chlorophyll a maximum concentration occurred in May (3.53 mg/m{sup 3}), and the minimum in January (0.39 mg/m{sup 3}). Phytoplankton chlorophyll a concentrations appear to be influenced by hydro-operations and temperature. Trophic status as indicated by phytoplankton chlorophyll a concentrations place Lake Roosevelt in the oligomesotrophic range. Periphyton colonization rates and biovolume were significantly greater at a depth

  8. EIS-0491: Record of Decision (Lake Charles Exports, LLC) | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energy Exports, LLC) EIS-0491: Record of Decision (Lake Charles Exports, LLC) Lake Charles Liquefaction Project; Calcasieu Parish, Louisiana DOE announced its decision in Lake Charles Exports, LLC (LCE), DOE/FE Docket No. 11-59-LNG, to issue DOE/FE Order No. 3324-A, granting final long-term, multi contract authorization for LCE to engage in the export of domestically produced liquefied natural gas (LNG) from the Lake Charles Terminal located in Lake Charles, Calcasieu Parish, Louisiana, in a

  9. EIS-0491: Record of Decision (Lake Charles LNG Export Company, LLC) |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy LNG Export Company, LLC) EIS-0491: Record of Decision (Lake Charles LNG Export Company, LLC) Lake Charles Liquefaction Project; Calcasieu Parish, Louisiana DOE announced its decision in Lake Charles LNG Export Company, LLC (Lake Charles LNG Export), DOE/FE Docket No. 13-04-LNG1, to issue DOE/FE Order No. 3868 granting final long-term, multi contract authorization for Lake Charles LNG Export to engage in export of domestically produced liquefied natural gas (LNG) from the

  10. Norris-lake-big-ridge-tn1_caption.jpg | OSTI, US Dept of Energy Office of

    Office of Scientific and Technical Information (OSTI)

    Scientific and Technical Information Norris-lake-big-ridge-tn1_caption

  11. miR-15a/16 Enhances Radiation Sensitivity of Non-Small Cell Lung Cancer Cells by Targeting the TLR1/NF-κB Signaling Pathway

    SciTech Connect

    Lan, Fengming; Yue, Xiao; Ren, Gang; Li, Hongqi; Ping, Li; Wang, Yingjie; Xia, Tingyi

    2015-01-01

    Purpose: Many miRNAs have been identified as essential issues and core determining factors in tumor radiation. Recent reports have demonstrated that miRNAs and Toll-like receptors could exert reciprocal effects to control cancer development in various ways. However, a novel role of miR-15a/16 in enhancing radiation sensitivity by directly targeting TLR1 has not been reported, to our knowledge. Methods and Materials: Bioinformatic analyses, luciferase reporter assay, biochemical assays, and subcutaneous tumor establishment were used to characterize the signaling pathways of miRNA-15a/16 in response to radiation treatment. Results: First, an inverse correlation between the expression of miR-15a/16 and TLR1 protein was revealed in non-small cell lung cancer (NSCLC) and normal lung tissues. Next, we corroborated that miR-15a/16 specifically bound to TLR1 3′UTR and inhibited the expression of TLR1 in H358 and A549 cells. Furthermore, miR-15a/16 downregulated the activity of the NF-κB signaling pathway through TLR1. In addition, overexpression of miR-15a/16 inhibited survival capability and increased radiation-induced apoptosis, resulting in enhancement of radiosensitivity in H358 and A549 cells. Finally, subcutaneous tumor bearing NSCLC cells in a nude mice model was established, and the results showed that combined groups (miR-15a/16 + radiation) inhibited tumor growth more significantly than did radiation alone. Conclusions: We mainly elucidate that miRNA-15a/16 can enhance radiation sensitivity by regulating the TLR1/NF-κB signaling pathway and act as a potential therapeutic approach to overcome radioresistance for lung cancer treatment.

  12. St. Clair, MI Natural Gas Pipeline Imports From Canada (Million Cubic Feet)

    Energy Information Administration (EIA) (indexed site)

    Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 14,132 11,855 34,592 33,388 2000's 17,198 21,747 28,441 5,202 22,853 18,281 10,410 9,633 9,104 6,544 2010's 5,591 5,228 3,531 6,019 16,409 9,024 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Natural Gas Pipeline Imports by Point of Entry St. Clair, MI Natural

  13. Proceedings of the Great Lakes Solar Greenhouse Conference V

    SciTech Connect

    Currin, C.G. (ed.)

    1983-01-01

    Proceedings of the Fifth Great Lakes Greenhouse Conference are presented. Topics included are: a review of a greenhouses, greenhouses as integral part of an earth-sheltered home, solar architecture, design criteria, heat contribution for solar greenhouses, and the future of solar greenhouses.

  14. Proceedings of the Great Lakes Solar Greenhouse Conference V

    SciTech Connect

    Currin, C.G. (ed.)

    1983-01-01

    Proceedings of the Fifth Great Lakes Solar Greenhouse Conference are presented. Topics included are a review of greenhouses, greenhouses as integral part of an earth-sheltered house, solar architecture, design criteria, heat contribution from solar greenhouses, and the future for solar greenhouses.

  15. Changing Weather and Climate in the Great Lakes Region Webinar

    Energy.gov [DOE]

    Offered by the University of Wisconsin-Madison through Coursera, this four-week course will feature a new season each week through short lectures and activities covering Great Lakes weather, observed changes in the climate, and societal impacts of climate change.

  16. Salt Lake City, Utah: Solar in Action (Brochure)

    SciTech Connect

    Not Available

    2011-10-01

    This brochure provides an overview of the challenges and successes of Salt Lake City, UT, a 2007 Solar America City awardee, on the path toward becoming a solar-powered community. Accomplishments, case studies, key lessons learned, and local resource information are given.

  17. QER- Comment of Lake Charles Harbor & Terminal District

    Energy.gov [DOE]

    Good Afternoon, Please find the Lake Charles Harbor and Terminal District’s comments on Infrastructure Constraints in re: the QER Investigation hearing scheduled for Bismarck, ND on August 8, 2014. Please include these comments in the public record of the hearing. Thank you.

  18. DIRECT MEASUREMENT OF HEAT FLUX FROM COOLING LAKE THERMAL IMAGERY

    SciTech Connect

    Garrett, A; Eliel Villa-Aleman, E; Robert Kurzeja, R; Malcolm Pendergast, M; Timothy Brown, T; Saleem Salaymeh, S

    2007-12-19

    Laboratory experiments show a linear relationship between the total heat flux from a water surface to air and the standard deviation of the surface temperature field, {sigma}, derived from thermal images of the water surface over a range of heat fluxes from 400 to 1800 Wm{sup -2}. Thermal imagery and surface data were collected at two power plant cooling lakes to determine if the laboratory relationship between heat flux and {sigma} exists in large heated bodies of water. The heat fluxes computed from the cooling lake data range from 200 to 1400 Wm{sup -2}. The linear relationship between {sigma} and Q is evident in the cooling lake data, but it is necessary to apply band pass filtering to the thermal imagery to remove camera artifacts and non-convective thermal gradients. The correlation between {sigma} and Q is improved if a correction to the measured {sigma} is made that accounts for wind speed effects on the thermal convection. Based on more than a thousand cooling lake images, the correlation coefficients between {sigma} and Q ranged from about 0.8 to 0.9.

  19. Lake Roosevelt Fisheries Evaluation Program : Lake Whatcom Kokanee Salmon (Oncorhynchus nerka kennerlyi) : Investigations in Lake Roosevelt Annual Report 1999-2000.

    SciTech Connect

    McLellan, Holly J.; Scholz, Allan T.; McLellan, Jason G.; Tilson, Mary Beth

    2001-07-01

    Lake Whatcom stock kokanee have been planted in Lake Roosevelt since 1988 with the primary goal of establishing a self-sustaining fishery. Returns of hatchery kokanee to egg collection facilities and recruitment to the creel have been minimal. Therefore, four experiments were conducted to determine the most appropriate release strategy that would increase kokanee returns. The first experiment compared morpholine and non-morpholine imprinted kokanee return rates, the second experiment compared early and middle run Whatcom kokanee, the third experiment compared early and late release dates, and the fourth experiment compared three net pen release strategies: Sherman Creek hatchery vs. Sherman Creek net pens, Colville River net pens vs. Sherman Creek net pens, and upper vs. lower reservoir net pen releases. Each experiment was tested in three ways: (1) returns to Sherman Creek, (2) returns to other tributaries throughout the reservoir, and (3) returns to the creel. Chi-square analysis of hatchery and tributary returns indicated no significant difference between morpholine imprinted and non-imprinted fish, early run fish outperformed middle run fish, early release date outperformed late release fish, and the hatchery outperformed all net pen releases. Hatchery kokanee harvest was estimated at 3,323 fish, which was 33% of the total harvest. Return rates (1998 = 0.52%) of Whatcom kokanee were low indicating an overall low performance that could be caused by high entrainment, predation, and precocity. A kokanee stock native to the upper Columbia, as opposed to the coastal Whatcom stock, may perform better in Lake Roosevelt.

  20. Observation of Disappearance of Muon Neutrinos in the NuMI Beam

    SciTech Connect

    Pavlovic, Zarko

    2008-05-01

    The Main Injector Neutrino Oscillation Search (MINOS) is a two detector long-baseline neutrino experiment designed to study the disappearance of muon neutrinos. MINOS will test the vμ → vτ oscillation hypothesis and measure precisely Δm232 and sin223 oscillation parameters. The source of neutrinos for MINOS experiment is Fermilab's Neutrinos at the Main Injector (NuMI) beamline. The energy spectrum and the composition of the beam is measured at two locations, one close to the source and the other 735 km down-stream in the Soudan Mine Underground Laboratory in northern Minnesota. The precision measurement of the oscillation parameters requires an accurate prediction of the neutrino flux at the Far Detector. This thesis discusses the calculation of the neutrino flux at the Far Detector and its uncertainties. A technique that uses the Near Detector data to constrain the uncertainties in the calculation of the flux is described. The data corresponding to an exposure of 2.5 x 1020 protons on the NuMI target is presented and an energy dependent disappearance pattern predicted by neutrino oscillation hypotheses is observed in the Far Detector data. The fit to MINOS data, for given exposure, yields the best fit values for Δm$2\\atop{23}$ and sin223 to be (2.38$+0.20\\atop{-0.16}$) x 10-3 eV2/c4and 1.00-0.08, respectively.