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Sample records for manager toiyabe nf

  1. USFS Humboldt-Toiyabe National Forest | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    USFS Humboldt-Toiyabe National Forest Jump to: navigation, search Name: USFS Humboldt-Toiyabe National Forest Abbreviation: Humbolt-Toiyabe NF Address: 1200 Franklin Way Place:...

  2. NVN-074253 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1280 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

  3. NVN-074250 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1199 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

  4. NVN-077646 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Acres) Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 80 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

  5. NVN-079352 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Acres) Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1160 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

  6. NVN-074254 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2280 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

  7. NVN-079310 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 655 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

  8. NVN-079667 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1920 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

  9. NVN-079664 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1280 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

  10. NVN-079276 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 640 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

  11. NVN-079292 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1980.23 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

  12. NVN-077739 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Lot Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1271.82 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 PATUA...

  13. NVN-079305 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    1 Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1811.109 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

  14. NVN-079104 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2480.99 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 ORNI 16...

  15. NVN-080086 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Acres) Case Status Authorized Case Type GEOLEASENONCOMPETITI Total Acreage 650.32 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 NGP BLUE...

  16. NVN-079306 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    B Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2140.53 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

  17. NVN-080159 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 NGP BLUE MOUNTAIN I LLC Lessee 2 none provided Effective Date 7312016 Expire Date Held By...

  18. NVN-079105 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2356.36 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 ORNI 16...

  19. NVN-079291 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Manager TOIYABE NF Lessee 1 GRADIENT RESOURCES INC Lessee 2 none provided Effective Date 612006 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action...

  20. NVN-079666 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Manager TOIYABE NF Lessee 1 GRADIENT RESOURCES INC Lessee 2 none provided Effective Date 712005 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action...

  1. NVN-078688 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Manager TOIYABE NF Lessee 1 REESE RIVER GEO POWER LLC Lessee 2 none provided Effective Date 1012004 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action...

  2. NVN-079665 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Manager TOIYABE NF Lessee 1 GRADIENT RESOURCES INC Lessee 2 none provided Effective Date 712005 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action...

  3. NVN-079307 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Manager TOIYABE NF Lessee 1 GRADIENT RESOURCES INC Lessee 2 none provided Effective Date 712006 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action...

  4. NVN-079106 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Surface Manager TOIYABE NF Lessee 1 ORNI 16 LLC Lessee 2 none provided Effective Date 912006 Expire Date Held By Production (HBP) HBP Date RoyaltyRate 10% - 5% - 5% Most...

  5. NVN-077647 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Manager TOIYABE NF Lessee 1 GRADIENT RESOURCES INC Lessee 2 none provided Effective Date 612006 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action...

  6. NVN-079662 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Manager TOIYABE NF Lessee 1 GRADIENT RESOURCES INC Lessee 2 none provided Effective Date 6302015 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action...

  7. NVN-074249 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Manager TOIYABE NF Lessee 1 GRADIENT RESOURCES INC Lessee 2 none provided Effective Date 912007 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action...

  8. NVN-079663 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Manager TOIYABE NF Lessee 1 GRADIENT RESOURCES INC Lessee 2 none provided Effective Date 712005 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action...

  9. NVN-078687 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Manager TOIYABE NF Lessee 1 REESE RIVER GEO POWER LLC Lessee 2 none provided Effective Date 1012004 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action...

  10. NVN-079668 | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Manager TOIYABE NF Lessee 1 GRADIENT RESOURCES INC Lessee 2 none provided Effective Date 712005 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action...

  11. ARM - VAP Product - aerich1nf1turn

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Productsaerinfaerich1nf1turn Documentation Data Management Facility Plots (Quick Looks) Citation DOI: 10.5439/1027272 [ What is this? ] Generate Citation ARM Data Discovery Browse Data Comments? We would love to hear from you! Send us a note below or call us at 1-888-ARM-DATA. Send VAP Output : AERICH1NF1TURN AERI ch. 1

  12. ARM - VAP Product - aerich2nf1turn

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Productsaerinfaerich2nf1turn Documentation Data Management Facility Plots (Quick Looks) Citation DOI: 10.5439/1027273 [ What is this? ] Generate Citation ARM Data Discovery Browse Data Comments? We would love to hear from you! Send us a note below or call us at 1-888-ARM-DATA. Send VAP Output : AERICH2NF1TURN AERI ch. 2

  13. NF Energy Saving Corp | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    NF Energy Saving Corp Jump to: navigation, search Name: NF Energy Saving Corp Place: Shenyang, Liaoning Province, China Sector: Services Product: China-based company provides...

  14. CMRR-NF Supplemental EIS Scoping Comments | National Nuclear Security

    National Nuclear Security Administration (NNSA)

    Administration | (NNSA) CMRR-NF Supplemental EIS Scoping Comments CMRR-NF Supplemental EIS Scoping Comments Additional CMRR Scoping Comments - 47A Additional CMRR Scoping Comments - 48A Additional CMRR Scoping Comments - 62 Additional CMRR Scoping Comments - 63 Additional CMRR Scoping Comments - 64 Additional CMRR Scoping Comments - 66A Additional CMRR Scoping Comments - 66B Additional CMRR Scoping Comments - 66C Additional CMRR Scoping Comments - 76 Additional CMRR Scoping Comments - 77

  15. management

    National Nuclear Security Administration (NNSA)

    5%2A en Management and Budget http:www.nnsa.energy.govaboutusouroperationsmanagementandbudget

  16. management

    National Nuclear Security Administration (NNSA)

    5%2A en Management and Budget http:nnsa.energy.govaboutusouroperationsmanagementandbudget

    P...

  17. IDS-NF Impact of Neutrino Cross Section Impact of Neutrino Cross Section

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    IDS-NF Impact of Neutrino Cross Section Impact of Neutrino Cross Section Knowledge on Oscillation Knowledge on Oscillation Measurements Measurements M. Sorel, IFIC (CSIC and U. of Valencia) IDS-NF, RAL, Jan 16-17 2008 M. Sorel - IFIC (Valencia U. & CSIC) 2 IDS-NF Neutrino Cross Sections: At What Energies Needed? Superbeams: Solid: T2K Dashed: NovA M. Sorel - IFIC (Valencia U. & CSIC) 3 IDS-NF Neutrino Cross Sections: At What Energies Needed? Superbeams: Solid: T2K Dashed: NovA Beta

  18. Property:SurfaceManager | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    + COCONINO NF + AZA-009169 + COCONINO NF + AZA-009170 + COCONINO NF + AZA-009171 + FOREST SERVICE + AZA-009172 + FOREST SERVICE + AZA-009173 + FOREST SERVICE + AZA-009174 +...

  19. Smoothing single-crystalline SiC surfaces by reactive ion etching using pure NF{sub 3} and NF{sub 3}/Ar mixture gas plasmas

    SciTech Connect (OSTI)

    Tasaka, Akimasa; Kotaka, Yuki; Oda, Atsushi; Saito, Morihiro; Tojo, Tetsuro; Inaba, Minoru

    2014-09-01

    In pure NF{sub 3} plasma, the etching rates of four kinds of single-crystalline SiC wafer etched at NF{sub 3} pressure of 2 Pa were the highest and it decreased with an increase in NF{sub 3} pressure. On the other hand, they increased with an increase in radio frequency (RF) power and were the highest at RF power of 200 W. A smooth surface was obtained on the single-crystalline 4H-SiC after reactive ion etching at NF{sub 3}/Ar gas pressure of 2 Pa and addition of Ar to NF{sub 3} plasma increased the smoothness of SiC surface. Scanning electron microscopy observation revealed that the number of pillars decreased with an increase in the Ar-concentration in the NF{sub 3}/Ar mixture gas. The roughness factor (R{sub a}) values were decreased from 51.5 nm to 25.5 nm for the As-cut SiC, from 0.25 nm to 0.20 nm for the Epi-SiC, from 5.0 nm to 0.7 nm for the Si-face mirror-polished SiC, and from 0.20 nm to 0.16 nm for the C-face mirror-polished SiC by adding 60% Ar to the NF{sub 3} gas. Both the R{sub a} values of the Epi- and the C-face mirror-polished wafer surfaces etched using the NF{sub 3}/Ar (40:60) plasma were similar to that treated with mirror polishing, so-called the Catalyst-Referred Etching (CARE) method, with which the lowest roughness of surface was obtained among the chemical mirror polishing methods. Etching duration for smoothing the single-crystalline SiC surface using its treatment was one third of that with the CARE method.

  20. BFV activates the NF-kappaB pathway through its transactivator (BTas) to enhance viral transcription

    SciTech Connect (OSTI)

    Wang Jian; Tan Juan; Zhang Xihui; Guo Hongyan; Zhang Qicheng; Guo Tingting; Geng Yunqi; Qiao Wentao

    2010-05-10

    Multiple families of viruses have evolved sophisticated strategies to regulate nuclear factor-kappaB (NF-kappaB) signaling, which plays a pivotal role in diverse cellular events, including virus-host interactions. In this study, we report that bovine foamy virus (BFV) is able to activate the NF-kappaB pathway through the action of its transactivator, BTas. Both cellular IKKbeta and IkappaBalpha also participate in this activation. In addition, we demonstrate that BTas induces the processing of p100, which implies that BTas can activate NF-kappaB through a noncanonical pathway as well. Co-immunoprecipitation analysis shows that BTas interacts with IKK catalytic subunits (IKKalpha and IKKbeta), which may be responsible for regulation of IKK kinase activity and persistent NF-kappaB activation. Furthermore, our results indicate that the level of BTas-mediated LTR transcription correlates with the activity of cellular NF-kappaB. Together, this study suggests that BFV activates the NF-kappaB pathway through BTas to enhance viral transcription.

  1. Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NF{kappa}B

    SciTech Connect (OSTI)

    Eliseev, Roman A. . E-mail: Roman_Eliseev@urmc.rochester.edu; Schwarz, Edward M.; Zuscik, Michael J.; O'Keefe, Regis J.; Drissi, Hicham; Rosier, Randy N.

    2006-01-01

    The transcription factor NF{kappa}B is constitutively activated in various tumor cells where it promotes proliferation and represses apoptosis. The bone morphogenetic proteins (BMPs) delay cell proliferation and promote differentiation and apoptosis of bone cells through activation of Smad downstream effectors and via Smad-independent mechanisms. Thus, NF{kappa}B and BMP pathways play opposing roles in regulating osteoblastic cell fate. Here, we show that in osteosarcoma Saos2 osteoblasts, NF{kappa}B regulates the activity of the BMP/Smad signaling. Inhibition of NF{kappa}B by overexpression of mI{kappa}B leads to the induction of osteoblast differentiation. Saos2 cells overexpressing mI{kappa}B (Saos2-mI{kappa}B) exhibit higher expression of osteoblast phenotypic genes such as alkaline phosphatase, Runx2 and osteocalcin and are more responsive to BMP2 in comparison to wild-type cells (Saos2-wt) or empty vector infected controls (Saos2-EV). Furthermore, BMP-2 signaling and Smad phosphorylation are significantly increased in Saos2-mI{kappa}B cells in comparison to Saos2-EV cells. Inhibition of NF{kappa}B signaling in Saos2-mI{kappa}B cells is associated with decreased expression of the BMP signaling inhibitor Smad7. While gain of Smad7 function in Saos2-mI{kappa}B cells results in inhibition of BMP signaling, anti-sense knockdown of Smad7 in Saos2-EV cells leads to upregulation of BMP signaling. We therefore conclude that in osteosarcoma Saos2 cells, NF{kappa}B represses BMP/Smad signaling and BMP2-induced differentiation through Smad7.

  2. Regulation Of Nf=kb And Mnsod In Low Dose Radiation Induced Adaptive Protection Of Mouse And Human Skin Cells

    SciTech Connect (OSTI)

    Jian Li

    2012-11-07

    A sampling of publications resulting from this grant is provided. One is on the subject of NF-κB-Mediated HER2 Overexpression in Radiation-Adaptive Resistance. Another is on NF-κB-mediated adaptive resistance to ionizing radiation.

  3. OSU-A9 inhibits angiogenesis in human umbilical vein endothelial cells via disrupting AktNF-?B and MAPK signaling pathways

    SciTech Connect (OSTI)

    Omar, Hany A.; Arafa, El-Shaimaa A.; Salama, Samir A.; Arab, Hany H.; Wu, Chieh-Hsi; Weng, Jing-Ru

    2013-11-01

    Since the introduction of angiogenesis as a useful target for cancer therapy, few agents have been approved for clinical use due to the rapid development of resistance. This problem can be minimized by simultaneous targeting of multiple angiogenesis signaling pathways, a potential strategy in cancer management known as polypharmacology. The current study aimed at exploring the anti-angiogenic activity of OSU-A9, an indole-3-carbinol-derived pleotropic agent that targets mainly Aktnuclear factor-kappa B (NF-?B) signaling which regulates many key players of angiogenesis such as vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs). Human umbilical vein endothelial cells (HUVECs) were used to study the in vitro anti-angiogenic effect of OSU-A9 on several key steps of angiogenesis. Results showed that OSU-A9 effectively inhibited cell proliferation and induced apoptosis and cell cycle arrest in HUVECs. Besides, OSU-A9 inhibited angiogenesis as evidenced by abrogation of migration/invasion and Matrigel tube formation in HUVECs and attenuation of the in vivo neovascularization in the chicken chorioallantoic membrane assay. Mechanistically, Western blot, RT-PCR and ELISA analyses showed the ability of OSU-A9 to inhibit MMP-2 production and VEGF expression induced by hypoxia or phorbol-12-myristyl-13-acetate. Furthermore, dual inhibition of AktNF-?B and mitogen-activated protein kinase (MAPK) signaling, the key regulators of angiogenesis, was observed. Together, the current study highlights evidences for the promising anti-angiogenic activity of OSU-A9, at least in part through the inhibition of AktNF-?B and MAPK signaling and their consequent inhibition of VEGF and MMP-2. These findings support OSU-A9's clinical promise as a component of anticancer therapy. - Highlights: The antiangiogenic activity of OSU-A9 in HUVECs was explored. OSU-A9 inhibited HUVECs proliferation, migration, invasion and tube formation. OSU-A9 targeted signaling

  4. Withaferin A disrupts ubiquitin-based NEMO reorganization induced by canonical NF-κB signaling

    SciTech Connect (OSTI)

    Jackson, Shawn S.; Oberley, Christopher; Hooper, Christopher P.; Grindle, Kreg; Wuerzberger-Davis, Shelly; Wolff, Jared; and others

    2015-02-01

    The NF-κB family of transcription factors regulates numerous cellular processes, including cell proliferation and survival responses. The constitutive activation of NF-κB has also emerged as an important oncogenic driver in many malignancies, such as activated B-cell like diffuse large B cell lymphoma, among others. In this study, we investigated the impact and mechanisms of action of Withaferin A, a naturally produced steroidal lactone, against both signal-inducible as well as constitutive NF-κB activities. We found that Withaferin A is a robust inhibitor of canonical and constitutive NF-κB activities, leading to apoptosis of certain lymphoma lines. In the canonical pathway induced by TNF, Withaferin A did not disrupt RIP1 polyubiquitination or NEMO–IKKβ interaction and was a poor direct IKKβ inhibitor, but prevented the formation of TNF-induced NEMO foci which colocalized with TNF ligand. While GFP-NEMO efficiently formed TNF-induced foci, a GFP-NEMO{sup Y308S} mutant that is defective in binding to polyubiquitin chains did not form foci. Our study reveals that Withaferin A is a novel type of IKK inhibitor which acts by disrupting NEMO reorganization into ubiquitin-based signaling structures in vivo. - Highlights: • Withaferin A, a NF-κB inhibitor, disrupts signaling induced NEMO localization, a novel point of inhibition. • NEMO can be localized to distinct signaling foci after treatment with TNF. • ABC-type DLCBL cells can be sensitized to apoptosis after treatment with Withaferin A.

  5. Piperlongumine selectively suppresses ABC-DLBCL through inhibition of NF-κB p65 subunit nuclear import

    SciTech Connect (OSTI)

    Niu, Mingshan; Shen, Yangling; Xu, Xiaoyu; Yao, Yao; Fu, Chunling; Yan, Zhiling; Wu, Qingyun; Cao, Jiang; Sang, Wei; Zeng, Lingyu; Li, Zhenyu; Liu, Xuejiao; and others

    2015-07-10

    Constitutive NF-κB activation is required for survival of activated B cell-like subtype of diffuse large B cell lymphoma (ABC-DLBCL). However, current NF-κB targeting strategies lack cancer cell specificity. Here, we identified a novel inhibitor, piperlongumine, features direct binding to NF-κB p65 subunit and suppression of p65 nuclear import. This was accompanied by NF-κB reporter activity suppression and NF-κB target gene downregulation. Moreover, mutation of Cys{sup 38} to Ser in p65 abolished this effect of piperlongumine on inhibition of p65 nuclear import. Furthermore, we show that piperlongumine selectively inhibited proliferation and induced apoptosis of ABC-DLBCL cells. Most notably, it has been reported that piperlongumine did not affect normal cells even at high doses and was nontoxic to animals. Hence, our current study provides new insight into piperlongumine's mechanism of action and novel approach to ABC-DLBCL target therapy. - Highlights: • Current NF-κB targeting strategies lack cancer cell specificity. • Piperlongumine inhibits NF-κB p65 subunit nuclear import via directly binding to p65. • Piperlongumine selectively inhibits proliferation of ABC-DLBCL cells. • This study provides a novel approach to ABC-DLBCL target therapy.

  6. Coal dust contiguity-induced changes in the concentration of TNF- and NF- B p65 on the ocular surface

    SciTech Connect (OSTI)

    Sun, Z.Y.; Hong, J.; Liu, Z.Y.; Jin, X.D.; Gu, C.H.

    2009-07-01

    To observe the influence of coal dust on ocular surface of coal miners and rabbits with coal dust contiguity on expression TNF- and NF- Bp65 and dry eye occurrence. Expression TNF- and NF- Bp65 in ocular surface were determined. Results showed tear production, BUT and lysozyme decreased for coal miners and rabbits with coal dust contiguity. Coal dust exposure was linked to development of xerophthalmia, and induced a higher expression of NF- B p65 and TNF- perhaps as a mechanism to resist coal dust ocular surface injury.

  7. BRAF activated non-coding RNA (BANCR) promoting gastric cancer cells proliferation via regulation of NF-κB1

    SciTech Connect (OSTI)

    Zhang, Zhi-Xin; Liu, Zhi-Qiang; Jiang, Biao; Lu, Xin-Yang; Ning, Xiao-Fei; Yuan, Chuan-Tao; Wang, Ai-Liang

    2015-09-18

    Background and objective: Long non-coding RNA, BANCR, has been demonstrated to contribute to the proliferation and migration of tumors. However, its molecular mechanism underlying gastric cancer is still unknown. In present study, we investigated whether BANCR was involved in the development of gastric cancer cells via regulation of NF-κB1. Methods: Human gastric cancer tissues were isolated as well as human gastric cell lines MGC803 and BGC823 were cultured to investigate the role of BANCR in gastric cancer. Results: BANCR expression was significantly up-regulated in gastric tumor tissues and gastric cell lines. Down-regulation of BANCR inhibited gastric cancer cell growth and promoted cell apoptosis, and it also contributed to a significant decrease of NF-κB1 (P50/105) expression and 3′UTR of NF-κB1 activity. Overexpression of NF-κB1 reversed the effect of BANCR on cancer cell growth and apoptosis. MiroRNA-9 (miR-9) targeted NF-κB1, and miR-9 inhibitor also reversed the effects of BANCR on gastric cancer cell growth and apoptosis. Conclusion: BANCR was highly expressed both in gastric tumor tissues and in cancer cells. NF-κB1 and miR-9 were involved in the role of BANCR in gastric cancer cell growth and apoptosis. - Highlights: • BANCR up-regulated in gastric cancer (GC) tissues and cell lines MGC803 and BGC823. • Down-regulation of BANCR inhibited GC cell growth and promoted cell apoptosis. • Down-regulation of BANCR contributed to decreased 3′UTR of NF-κB1 and its expression. • Overexpressed NF-κB1 reversed the effect of BANCR on GC cell growth. • miR-9 inhibitor reversed the effect of BANCR on cancer GC cell growth.

  8. Agreement Execution Process Study: CRADAs and NF-WFO Agreements and the Speed of Business

    SciTech Connect (OSTI)

    Harrer, Bruce J.; Cejka, Cheryl L.; Macklin, Richard; Miksovic, Ann

    2011-02-01

    This report summarizes the findings of a study on the execution of Cooperative Research and Development Agreements (CRADAs) and Non-Federal Work for Others (NF-WFO) agreements across the U.S. Department of Energy (DOE) laboratory complex. The study provides quantitiative estimates of times required to negotiate and execute these agreements across the DOE complex. It identifies factors impacting on cycle times and describes best practicies used at various laboratories and site offices that reduce cycle times.

  9. XEDAR activates the non-canonical NF-κB pathway

    SciTech Connect (OSTI)

    Verhelst, Kelly; Gardam, Sandra; Borghi, Alice; Kreike, Marja; Carpentier, Isabelle; Beyaert, Rudi

    2015-09-18

    Members of the tumor necrosis factor receptor (TNFR) superfamily are involved in a number of physiological and pathological responses by activating a wide variety of intracellular signaling pathways. The X-linked ectodermal dysplasia receptor (XEDAR; also known as EDA2R or TNFRSF27) is a member of the TNFR superfamily that is highly expressed in ectodermal derivatives during embryonic development and binds to ectodysplasin-A2 (EDA-A2), a member of the TNF family that is encoded by the anhidrotic ectodermal dysplasia (EDA) gene. Although XEDAR was first described in the year 2000, its function and molecular mechanism of action is still largely unclear. XEDAR has been reported to activate canonical nuclear factor κB (NF-κB) signaling and mitogen-activated protein (MAP) kinases. Here we report that XEDAR is also able to trigger the non-canonical NF-κB pathway, characterized by the processing of p100 (NF-κB2) into p52, followed by nuclear translocation of p52 and RelB. We provide evidence that XEDAR-induced p100 processing relies on the binding of XEDAR to TRAF3 and TRAF6, and requires the kinase activity of NIK and IKKα. We also show that XEDAR stimulation results in NIK accumulation and that p100 processing is negatively regulated by TRAF3, cIAP1 and A20. - Highlights: • XEDAR activates the non-canonical NF-κB pathway. • XEDAR-induced processing of p100 depends on XEDAR interaction with TRAF3 and TRAF6. • XEDAR-induced processing of p100 depends on NIK and IKKα activity. • Overexpression of XEDAR leads to NIK accumulation. • XEDAR-induced processing of p100 is negatively regulated by TRAF3 cIAP1 and A20.

  10. Characterization of the Kinetics of NF3-Fluorination of NpO2

    SciTech Connect (OSTI)

    Casella, Andrew M.; Scheele, Randall D.; McNamara, Bruce K.

    2015-12-23

    The exploitation of selected actinide and fission product fluoride volatilities has long been considered as a potentially attractive compact method for recycling used nuclear fuels to avoid generating the large volumes of radioactive waste arising from aqueous reprocessing [1-7]. The most developed process uses the aggressive and hazardous fluorinating agents hydrogen fluoride (HF) and/or molecular fluorine (F2) at high temperatures to volatilize the greatest fraction of the used nuclear fuel into a single gas stream. The volatilized fluorides are subsequently separated using a series of fractionation and condensation columns to recover the valuable fuel constituents and fission products. In pursuit of a safer and less complicated approach, we investigated an alternative fluoride volatility-based process using the less hazardous fluorinating agent nitrogen trifluoride (NF3) and leveraging its less aggressive nature to selectively evolve fission product and actinide fluorides from the solid phase based on their reaction temperatures into a single recycle stream [8-15]. In this approach, successive isothermal treatments using NF3 will first evolve the more thermally susceptible used nuclear fuel constituents leaving the other constituents in the residual solids until subsequent isothermal temperature treatments cause these others to volatilize. During investigation of this process, individual neat used fuel components were treated with isothermal NF3 in an attempt to characterize the kinetics of each fluorination reaction to provide input into the design of a new volatile fluoride separations approach. In these directed investigations, complex behavior was observed between NF3 and certain solid reactants such as the actinide oxides of uranium, plutonium, and neptunium. Given the similar thermal reaction susceptibilities of neptunium oxide (NpO2) and uranium dioxide (UO2) and the importance of Np and U, we initially focused our efforts on determining the reaction

  11. Nickel differentially regulates NFAT and NF-{kappa}B activation in T cell signaling

    SciTech Connect (OSTI)

    Saito, Rumiko; Hirakawa, Satoshi; Ohara, Hiroshi; Yasuda, Makoto; Yamazaki, Tomomi; Nishii, Shigeaki; Aiba, Setsuya

    2011-08-01

    Nickel is a potent hapten that induces contact hypersensitivity in human skin. While nickel induces the maturation of dendritic cells via NF-{kappa}B and p38 MAPK activation, it also exerts immunosuppressive effects on T cells through an unknown mechanism. To elucidate the molecular mechanisms of its effects on T cells, we examined the effects of NiCl{sub 2} on mRNA expression in human CD3+ T cells stimulated with CD3 and CD28 antibodies. Using a DNA microarray and Gene Ontology, we identified 70 up-regulated (including IL-1{beta}, IL-6 and IL-8) and 61 down-regulated (including IL-2, IL-4, IL-10 and IFN-{gamma}) immune responsive genes in NiCl{sub 2}-treated T cells. The DNA microarray results were verified using real-time PCR and a Bio-Plex{sup TM} suspension protein array. Suppression of IL-2 and IFN-{gamma} gene transcription by NiCl{sub 2} was also confirmed using Jurkat T cells transfected with IL-2 or IFN-{gamma} luciferase reporter genes. To explore the NiCl{sub 2}-regulated signaling pathway, we examined the binding activity of nuclear proteins to NFAT, AP-1, and NF-{kappa}B consensus sequences. NiCl{sub 2} significantly and dose-dependently suppressed NFAT- and AP-1-binding activity, but augmented NF-{kappa}B-binding activity. Moreover, NiCl{sub 2} decreased nuclear NFAT expression in stimulated T cells. Using Jurkat T cells stimulated with PMA/ionomycin, we demonstrated that NiCl{sub 2} significantly suppressed stimulation-evoked cytosolic Ca{sup 2+} increases, suggesting that NiCl{sub 2} regulates NFAT signals by acting as a blocker of Ca{sup 2+} release-activated Ca{sup 2+} (CRAC) channels. These data showed that NiCl{sub 2} decreases NFAT and increases NF-{kappa}B signaling in T cells. These results shed light on the effects of nickel on the molecular regulation of T cell signaling. - Graphical Abstract: Nickel suppresses stimulation-evoked cytosolic Ca{sup 2+} increase, which results in the suppression of NFAT signals. On the other hand, Ni rather

  12. XIAP Induces NF-kB Activation via the BIR1/TAB1 Interaction and BIR1 Dimerization

    SciTech Connect (OSTI)

    Lu,M.; Lin, S.; Huang, Y.; Kang, Y.; Rich, R.; Lo, Y.; Myszka, D.; Han, J.; Wu, H.

    2007-01-01

    In addition to caspase inhibition, X-linked inhibitor of apoptosis (XIAP) induces NF-{kappa}B and MAP kinase activation during TGF-b and BMP receptor signaling and upon overexpression. Here we show that the BIR1 domain of XIAP, which has no previously ascribed function, directly interacts with TAB1 to induce NF-{kappa}B activation. TAB1 is an upstream adaptor for the activation of the kinase TAK1, which in turn couples to the NF-{kappa}B pathway. We report the crystal structures of BIR1, TAB1, and the BIR1/TAB1 complex. The BIR1/TAB1 structure reveals a striking butterfly-shaped dimer and the detailed interaction between BIR1 and TAB1. Structure-based mutagenesis and knockdown of TAB1 show unambiguously that the BIR1/TAB1 interaction is crucial for XIAP-induced TAK1 and NF-{kappa}B activation. We show that although not interacting with BIR1, Smac, the antagonist for caspase inhibition by XIAP, also inhibits the XIAP/TAB1 interaction. Disruption of BIR1 dimerization abolishes XIAP-mediated NF-{kappa}B activation, implicating a proximity-induced mechanism for TAK1 activation.

  13. Constitutive NF-?B activation and tumor-growth promotion by Romo1-mediated reactive oxygen species production

    SciTech Connect (OSTI)

    Chung, Jin Sil; Lee, Sora; Yoo, Young Do

    2014-08-08

    Highlights: Romo1 expression is required for constitutive nuclear DNA-binding activity of NF-?B. Romo1 depletion suppresses tumor growth in vivo. Romo1 presents a potential therapeutic target for diseases. - Abstract: Deregulation of nuclear factor-?B (NF-?B) and related pathways contribute to tumor cell proliferation and invasion. Mechanisms for constitutive NF-?B activation are not fully explained; however, the underlying defects appear to generate and maintain pro-oxidative conditions. In hepatocellular carcinoma (HCC) tissues, up-regulation of reactive oxygen species modulator 1 (Romo1) correlates positively with tumor size. In the present study, we showed that Romo1 expression is required to maintain constitutive nuclear DNA-binding activity of NF-?B and transcriptional activity through constitutive I?B? phosphorylation. Overexpression of Romo1 promoted p65 nuclear translocation and DNA-binding activity. We also show that Romo1 depletion suppressed anchorage-independent colony formation by HCC cells and suppressed tumor growth in vivo. Based on these findings, Romo1 may be a principal regulatory factor in the maintenance of constitutive NF-?B activation in tumor cells. In the interest of anti-proliferative treatments for cancer, Romo1 may also present a productive target for drug development.

  14. FY13 Summary Report on the Augmentation of the Spent Fuel Composition Dataset for Nuclear Forensics: SFCOMPO/NF

    SciTech Connect (OSTI)

    Brady Raap, Michaele C.; Lyons, Jennifer A.; Collins, Brian A.; Livingston, James V.

    2014-03-31

    This report documents the FY13 efforts to enhance a dataset of spent nuclear fuel isotopic composition data for use in developing intrinsic signatures for nuclear forensics. A review and collection of data from the open literature was performed in FY10. In FY11, the Spent Fuel COMPOsition (SFCOMPO) excel-based dataset for nuclear forensics (NF), SFCOMPO/NF was established and measured data for graphite production reactors, Boiling Water Reactors (BWRs) and Pressurized Water Reactors (PWRs) were added to the dataset and expanded to include a consistent set of data simulated by calculations. A test was performed to determine whether the SFCOMPO/NF dataset will be useful for the analysis and identification of reactor types from isotopic ratios observed in interdicted samples.

  15. Intranuclear interactomic inhibition of NF-κB suppresses LPS-induced severe sepsis

    SciTech Connect (OSTI)

    Park, Sung-Dong; Cheon, So Yeong; Park, Tae-Yoon; Shin, Bo-Young; Oh, Hyunju; Ghosh, Sankar; Koo, Bon-Nyeo; Lee, Sang-Kyou

    2015-08-28

    Suppression of nuclear factor-κB (NF-κB) activation, which is best known as a major regulator of innate and adaptive immune responses, is a potent strategy for the treatment of endotoxic sepsis. To inhibit NF-κB functions, we designed the intra-nuclear transducible form of transcription modulation domain (TMD) of RelA (p65), called nt-p65-TMD, which can be delivered effectively into the nucleus without influencing the cell viability, and work as interactomic inhibitors via disruption of the endogenous p65-mediated transcription complex. nt-p65-TMD effectively inhibited the secretion of pro-inflammatory cytokines, including TNF-α, IL-1β, or IL-6 from BV2 microglia cells stimulated by lipopolysaccharide (LPS). nt-p65-TMD did not inhibit tyrosine phosphorylation of signaling mediators such as ZAP-70, p38, JNK, or ERK involved in T cell activation, but was capable of suppressing the transcriptional activity of NF-κB without the functional effect on that of NFAT upon T-cell receptor (TCR) stimulation. The transduced nt-p65-TMD in T cell did not affect the expression of CD69, however significantly inhibited the secretion of T cell-specific cytokines such as IL-2, IFN-γ, IL-4, IL-17A, or IL-10. Systemic administration of nt-p65-TMD showed a significant therapeutic effect on LPS-induced sepsis model by inhibiting pro-inflammatory cytokines secretion. Therefore, nt-p65-TMD can be a novel therapeutics for the treatment of various inflammatory diseases, including sepsis, where a transcription factor has a key role in pathogenesis, and further allows us to discover new functions of p65 under normal physiological condition without genetic alteration. - Highlights: • The nt-p65-TMD is intra-nuclear interactomic inhibitor of endogenous p65. • The nt-p65-TMD effectively inhibited the secretion of pro-inflammatory cytokines. • The excellent therapeutic potential of nt-p65-TMD was confirmed in sepsis model.

  16. 3D calculation of Tucson-Melbourne 3NF effect in triton binding energy

    SciTech Connect (OSTI)

    Hadizadeh, M. R.; Tomio, L.; Bayegan, S.

    2010-08-04

    As an application of the new realistic three-dimensional (3D) formalism reported recently for three-nucleon (3N) bound states, an attempt is made to study the effect of three-nucleon forces (3NFs) in triton binding energy in a non partial wave (PW) approach. The spin-isospin dependent 3N Faddeev integral equations with the inclusion of 3NFs, which are formulated as function of vector Jacobi momenta, specifically the magnitudes of the momenta and the angle between them, are solved with Bonn-B and Tucson-Melbourne NN and 3N forces in operator forms which can be incorporated in our 3D formalism. The comparison with numerical results in both, novel 3D and standard PW schemes, shows that non PW calculations avoid the very involved angular momentum algebra occurring for the permutations and transformations and it is more efficient and less cumbersome for considering the 3NF.

  17. PSMB4 promotes multiple myeloma cell growth by activating NF-κB-miR-21 signaling

    SciTech Connect (OSTI)

    Zheng, Peihao; Guo, Honggang; Li, Guangchao; Han, Siqi; Luo, Fei; Liu, Yi

    2015-03-06

    Proteasomal subunit PSMB4, was recently identified as potential cancer driver genes in several tumors. However, the regulatory mechanism of PSMB4 on carcinogenesis process remains unclear. In this study, we investigated the expression and roles of PSMB4 in multiple myeloma (MM). We found a significant up-regulation of PSMB4 in MM plasma and cell lines. Ectopic overexpression of PSMB4 promoted cell growth and colony forming ability of MM cells, whereas inhibition of PSMB4 led to a decrease of such events. Furthermore, our results demonstrated the up-regulation of miR-21 and a positive correlation between the levels of miR-21 and PSMB4 in MM. Re-expression of miR-21 markedly rescued PSMB4 knockdown-mediated suppression of cell proliferation and clone-formation. Additionally, while enforced expression of PSMB4 profoundly increased NF-κB activity and the level of miR-21, PSMB4 knockdown or NF-κB inhibition suppressed miR-21 expression in MM cells. Taken together, our results demonstrated that PSMB4 regulated MM cell growth in part by activating NF-κB-miR-21 signaling, which may represent promising targets for novel specific therapies. - Highlights: • First reported upregulation of PSMB4 in MM plasma and cell lines. • PSMB4 promoted MM cell growth and colony forming ability. • Further found miR-21 was up-regulated by PSMB4 in MM plasma and cell lines. • PSMB4-induced miR-21 expression was modulated by NF-κB. • PSMB4-NF-κB-miR-21 axis may be potential therapeutic targets of MM.

  18. 27-Oxygenated cholesterol induces expression of CXCL8 in macrophages via NF-κB and CD88

    SciTech Connect (OSTI)

    Kim, Sun-Mi; Lee, Chung Won; Kim, Bo-Young; Jung, Young-Suk; Eo, Seong-Kug; Park, Young Chul; Kim, Koanhoi

    2015-08-07

    We attempted to determine the effects of a milieu rich in cholesterol molecules on expression of chemokine CXCL8. A high-cholesterol diet led to an increased transcription of the IL-8 gene in the arteries and elevated levels of CXCL8 in sera of ApoE{sup −/−} mice, compared with those of wild-type C57BL/6 mice. Treatment of THP-1 monocyte/macrophage cells with 27-hydroxycholesterol (27OHChol) resulted in transcription of the IL-8 gene and increased secretion of its corresponding gene product whereas cholesterol did not induce expression of CXCL8 in THP-1 cells. 27OHChol-induced transcription of the IL-8 gene was blocked by cycloheximide, but not by polymyxin B. Treatment of THP-1 cells with 27OHChol caused translocation of p65 NF-κB subunit into the nucleus and up-regulation of CD88. Inhibition of NF-κB and CD88 using SN50 and W-54011, respectively, resulted in reduced transcription of the IL-8 gene and attenuated secretion of CXCL8 induced by 27OHChol. We propose that oxidatively modified cholesterol like 27OHChol, rather than cholesterol, is responsible for sustained expression of CXCL8 in monocytes/macrophages in atherosclerotic arteries. - Highlights: • Consumption of a high-cholesterol diet leads to increased CXCL8 expression in ApoE{sup −/−} mice. • 27OHChol, but not cholesterol, up-regulates expression of CXCL8 in macrophages. • 27OHChol enhances nuclear translocation of NF-κB and expression of CD88 in macrophages. • Inhibition of NF-κB or CD88 results in decreased CXCL8 expression induced by 27OHChol. • 27OHChol up-regulates CXCL8 expression via NF-κB and CD88 in macrophages.

  19. miR-339-5p inhibits alcohol-induced brain inflammation through regulating NF-κB pathway

    SciTech Connect (OSTI)

    Zhang, Yu; Wei, Guangkuan; Di, Zhiyong; Zhao, Qingjie

    2014-09-26

    Graphical abstract: - Highlights: • Alcohol upregulates miR-339-5p expression. • miR-339-5p inhibits the NF-kB pathway. • miR-339-5p interacts with and blocks activity of IKK-beat and IKK-epsilon. • miR-339-5p modulates IL-1β, IL-6 and TNF-α. - Abstract: Alcohol-induced neuroinflammation is mediated by the innate immunesystem. Pro-inflammatory responses to alcohol are modulated by miRNAs. The miRNA miR-339-5p has previously been found to be upregulated in alcohol-induced neuroinflammation. However, little has been elucidated on the regulatory functions of this miRNA in alcohol-induced neuroinflammation. We investigated the function of miR-339-5p in alcohol exposed brain tissue and isolated microglial cells using ex vivo and in vitro techniques. Our results show that alcohol induces transcription of miR 339-5p, IL-6, IL-1β and TNF-α in mouse brain tissue and isolated microglial cells by activating NF-κB. Alcohol activation of NF-κB allows for nuclear translocation of the NF-κB subunit p65 and expression of pro-inflammatory mediators. miR-339-5p inhibited expression of these pro-inflammatory factors through the NF-κB pathway by abolishing IKK-β and IKK-ε activity.

  20. Interleukin 6 promotes endometrial cancer growth through an autocrine feedback loop involving ERKNF-?B signaling pathway

    SciTech Connect (OSTI)

    Che, Qi; Liu, Bin-Ya; Wang, Fang-Yuan; He, Yin-Yan; Lu, Wen; Liao, Yun; Gu, Wei; Wan, Xiao-Ping

    2014-03-28

    Highlights: IL-6 could promote endometrial cancer cells proliferation. IL-6 promotes its own production through an autocrine feedback loop. ERK and NF-?B pathway inhibitors inhibit IL-6 production and tumor growth. IL-6 secretion relies on the activation of ERKNF-?B pathway axis. An orthotopic nude endometrial carcinoma model confirms the effect of IL-6. - Abstract: Interleukin (IL)-6 as an inflammation factor, has been proved to promote cancer proliferation in several human cancers. However, its role in endometrial cancer has not been studied clearly. Previously, we demonstrated that IL-6 promoted endometrial cancer progression through local estrogen biosynthesis. In this study, we proved that IL-6 could directly stimulate endometrial cancer cells proliferation and an autocrine feedback loop increased its production even after the withdrawal of IL-6 from the medium. Next, we analyzed the mechanism underlying IL-6 production in the feedback loop and found that its production and IL-6-stimulated cell proliferation were effectively blocked by pharmacologic inhibitors of nuclear factor-kappa B (NF-?B) and extra-cellular signal-regulated kinase (ERK). Importantly, activation of ERK was upstream of the NF-?B pathways, revealing the hierarchy of this event. Finally, we used an orthotopic nude endometrial carcinoma model to confirm the effects of IL-6 on the tumor progression. Taken together, these data indicate that IL-6 promotes endometrial carcinoma growth through an expanded autocrine regulatory loop and implicate the ERKNF-?B pathway as a critical mediator of IL-6 production, implying IL-6 to be an important therapeutic target in endometrial carcinoma.

  1. High glucose induces activation of NF-κB inflammatory signaling through IκBα sumoylation in rat mesangial cells

    SciTech Connect (OSTI)

    Huang, Wei; Department of Endocrinology, The People’s Hospital of Xindu, Xindu, Sichuang, 610500 ; Xu, Ling; Zhou, Xueqin; Department of Endocrinology, The People’s Hospital of Leshan, Sichuang ; Gao, Chenlin; Yang, Maojun; Chen, Guo; Zhu, Jianhua; Jiang, Lan; Gan, Huakui; Gou, Fang; Feng, Hong; Peng, Juan; Xu, Yong

    2013-08-30

    Highlights: •The expression of SUMO1, SUMO2/3 under high glucose was obviously enhanced. •High glucose induced degradation of IκBα and activation of NF-κB pathway. •Sumoylation of IκBα in high glucose were significantly decreased. •The proteasome inhibitor MG132 could partially revert the degradation of IκBα. -- Abstract: The posttranslational modification of proteins by small ubiquitin-like modifiers (SUMOs) has emerged as an important regulatory mechanism for the alteration of protein activity, stability, and cellular localization. The latest research demonstrates that sumoylation is extensively involved in the regulation of the nuclear factor κB (NF-κB) pathway, which plays a critical role in the regulation of inflammation and contributes to fibrosis in diabetic nephropathy (DN). However, the role of sumoylation in the regulation of NF-κB signaling in DN is still unclear. In the present study, we cultured rat glomerular mesangial cells (GMCs) stimulated by high glucose and divided GMCs into six groups: normal glucose group (5.6 mmol/L), high glucose groups (10, 20, and 30 mmol/L), mannitol group (i.e., osmotic control group), and MG132 intervention group (30 mmol/L glucose with MG132, a proteasome inhibitor). The expression of SUMO1, SUMO2/3, IκBα, NF-κBp65, and monocyte chemotactic protein 1 (MCP-1) was measured by Western blot, reverse-transcription polymerase chain reaction, and indirect immunofluorescence laser scanning confocal microscopy. The interaction between SUMO1, SUMO2/3, and IκBα was observed by co-immunoprecipitation. The results showed that the expression of SUMO1 and SUMO2/3 was dose- and time-dependently enhanced by high glucose (p < 0.05). However, the expression of IκBα sumoylation in high glucose was significantly decreased compared with the normal glucose group (p < 0.05). The expression of IκBα was dose- and time-dependently decreased, and NF-κBp65 and MCP-1 were increased under high glucose conditions, which

  2. Thermal Reactions of Uranium Metal, UO2, U3O8, UF4, and UO2F2 with NF3 to Produce UF6

    SciTech Connect (OSTI)

    McNamara, Bruce K.; Scheele, Randall D.; Kozelisky, Anne E.; Edwards, Matthew K.

    2009-11-01

    he objective of this paper is to demonstrate that NF3 fluorinates uranium metal, UO2, UF4, UO3, U3O8, and UO2F22H2O to produce the volatile UF6 at temperatures between 100 and 500?C. Thermogravimetric reaction profiles are described that reflect changes in the uranium oxidation state and discrete chemical speciation. Differences in the onset temperatures for each system indicate that NF3-substrate interactions are important for the temperature at which NF3 reacts: U metal > UO3 > UO2 > UO2F2 > UF4 and in fact may indicate different fluorination mechanisms for these various substrates. These studies demonstrate that NF3 is a potential replacement fluorinating agent in the existing nuclear fuel cycle and in oft-proposed actinide volatility reprocessing.

  3. Microstructural evolution of NF709 (20Cr–25Ni–1.5MoNbTiN) under neutron irradiation

    SciTech Connect (OSTI)

    Kim, Byoungkoo; Tan, Lizhen; Xu, C.; Yang, Yong; Zhang, Xuan; Li, Meimei

    2015-12-30

    In this study, because of its superior creep and corrosion resistance as compared with general austenitic stainless steels, NF709 has emerged as a candidate structural material for advanced nuclear reactors. To obtain fundamental information about the radiation resistance of this material, this study examined the microstructural evolution of NF709 subjected to neutron irradiation to 3 displacements per atom at 500 °C. Transmission electron microscopy, scanning electron microscopy, and high-energy x-ray diffraction were employed to characterize radiation-induced segregation, Frank loops, voids, as well as the formation and reduction of precipitates. Radiation hardening of ~76% was estimated by nanoindentation, approximately consistent with the calculation according to the dispersed barrier-hardening model, suggesting Frank loops as the primary hardening source.

  4. Microstructural evolution of NF709 (20Cr–25Ni–1.5MoNbTiN) under neutron irradiation

    DOE PAGES-Beta [OSTI]

    Kim, Byoungkoo; Tan, Lizhen; Xu, C.; Yang, Yong; Zhang, Xuan; Li, Meimei

    2015-12-30

    In this study, because of its superior creep and corrosion resistance as compared with general austenitic stainless steels, NF709 has emerged as a candidate structural material for advanced nuclear reactors. To obtain fundamental information about the radiation resistance of this material, this study examined the microstructural evolution of NF709 subjected to neutron irradiation to 3 displacements per atom at 500 °C. Transmission electron microscopy, scanning electron microscopy, and high-energy x-ray diffraction were employed to characterize radiation-induced segregation, Frank loops, voids, as well as the formation and reduction of precipitates. Radiation hardening of ~76% was estimated by nanoindentation, approximately consistent withmore » the calculation according to the dispersed barrier-hardening model, suggesting Frank loops as the primary hardening source.« less

  5. Simulated (n,f) cross section of isomeric 235m-U

    SciTech Connect (OSTI)

    Becker, J; Britt, H; Younes, W

    2003-12-18

    The neutron-induced fission cross section on the {sup 235}U, T{sub 1/2} {approx} 26 min isomer has been deduced for incident neutron energies in the range E{sub n}=0.1-2.5 MeV, using the surrogate-reaction technique. In this technique, {sup 236}U fission probabilities measured in the {sup 234}U(t, pf) reaction have been converted into {sup 235}U(n,f) and {sup 235m}U(n,f) cross sections, using reaction theory to compensate for the differences in angular-momentum and parity distributions in the fissioning systems, transferred by the (t,p) and neutron-induced reactions. Based on the comparison between the {sup 235}U(n,f) cross section extracted in this work and independent experimental data, the deduced {sup 235m}U(n,f) cross section is believed to be reliable to 20% below E{sub n} {approx} 0.5 MeV and 10% at higher energies. The surrogate-reaction technique, its validation in the case of the {sup 235}U(n,f) cross section, and the deduced {sup 235m}U(n,f) cross section are discussed. Validation of this method allows (n,f) cross sections for many short-lived nuclei, as well as isomeric nuclei, to be extracted from measured fission probabilities.

  6. Subneurotoxic copper(II)-induced NF-κB-dependent microglial activation is associated with mitochondrial ROS

    SciTech Connect (OSTI)

    Hu, Zhuqin; Yu, Fengxiang; Gong, Ping; Qiu, Yu; Zhou, Wei; Cui, Yongyao; Li, Juan Chen, Hongzhuan

    2014-04-15

    Microglia-mediated neuroinflammation and the associated neuronal damage play critical roles in the pathogenesis of neurodegenerative disorders. Evidence shows an elevated concentration of extracellular copper(II) in the brains of these disorders, which may contribute to neuronal death through direct neurotoxicity. Here we explored whether extracellular copper(II) triggers microglial activation. Primary rat microglia and murine microglial cell line BV-2 cells were cultured and treated with copper(II). The content of tumor necrosis factor-α (TNF-α) and nitric oxide in the medium was determined. Extracellular hydrogen peroxide was quantified by a fluorometric assay with Amplex Red. Mitochondrial superoxide was measured by MitoSOX oxidation. At subneurotoxic concentrations, copper(II) treatment induced a dose- and time-dependent release of TNF-α and nitric oxide from microglial cells, and caused an indirect, microglia-mediated neurotoxicity that was blocked by inhibition of TNF-α and nitric oxide production. Copper(II)-initiated microglial activation was accompanied with reduced IkB-α expression as well as phosphorylation and translocation of nuclear factor-κB (NF-κB) p65 and was blocked by NF-κB inhibitors (BAY11-7082 and SC-514). Moreover, copper(II) treatment evoked a rapid release of hydrogen peroxide from microglial cells, an effect that was not affected by NADPH oxidase inhibitors. N-acetyl-cysteine, a scavenger of reactive oxygen species (ROS), abrogated copper(II)-elicited microglial release of TNF-α and nitric oxide and subsequent neurotoxicity. Importantly, mitochondrial production of superoxide, paralleled to extracellular release of hydrogen peroxide, was induced after copper(II) stimulation. Our findings suggest that extracellular copper(II) at subneurotoxic concentrations could trigger NF-κB-dependent microglial activation and subsequent neurotoxicity. NADPH oxidase-independent, mitochondria-derived ROS may be involved in this activation

  7. Microsoft PowerPoint - Managing Uncertainty and Demonstrating Compliance

    Office of Environmental Management (EM)

    Low Dose DOE's Low Dose R di ti R h R di ti R h Radiation Research Radiation Research Program Program g g NF Metting, Sc.D., Program Manager Nuclear Energy Advisory Committee Meeting Nuclear Energy Advisory Committee Meeting L'Enfant Plaza Hotel L'Enfant Plaza Hotel 6 December 2012 Office of Science Office of Biological and Environmental Research DOE's Low Dose Program: DOE s Low Dose Program: Is unique within the U.S. government in focusing on low dose biological research aimed at informing

  8. SENP1 inhibition induces apoptosis and growth arrest of multiple myeloma cells through modulation of NF-κB signaling

    SciTech Connect (OSTI)

    Xu, Jun; Sun, Hui-Yan; Xiao, Feng-Jun; Wang, Hua; Yang, Yang; Wang, Lu; Gao, Chun-Ji; Guo, Zi-Kuan; Wu, Chu-Tse; Wang, Li-Sheng

    2015-05-01

    SUMO/sentrin specific protease 1 (Senp1) is an important regulation protease in the protein sumoylation, which affects the cell cycle, proliferation and differentiation. The role of Senp1 mediated protein desumoylation in pathophysiological progression of multiple myeloma is unknown. In this study, we demonstrated that Senp1 is overexpressed and induced by IL-6 in multiple myeloma cells. Lentivirus-mediated Senp1 knockdown triggers apoptosis and reduces viability, proliferation and colony forming ability of MM cells. The NF-κB family members including P65 and inhibitor protein IkBα play important roles in regulation of MM cell survival and proliferation. We further demonstrated that Senp1 inhibition decreased IL-6-induced P65 and IkBα phosphorylation, leading to inactivation of NF-kB signaling in MM cells. These results delineate a key role for Senp1in IL-6 induced proliferation and survival of MM cells, suggesting it may be a potential new therapeutic target in MM. - Highlights: • Senp1 is overexpressed and induced by IL-6 in multiple myeloma cells. • Senp1 knockdown triggers apoptosis and reduces proliferation of MM cells. • Senp1 inhibition decreased IL-6-induced P65 and IkBα phosphorylation.

  9. Oxaliplatin antagonizes HIV-1 latency by activating NF-κB without causing global T cell activation

    SciTech Connect (OSTI)

    Zhu, Xiaoli; Liu, Sijie; Wang, Pengfei; Qu, Xiying; Wang, Xiaohui; Zeng, Hanxian; Chen, Huabiao; Zhu, Huanzhang

    2014-07-18

    Highlights: • The chemotherapeutic drug oxaliplatin reactivates latent HIV-1 in this cell line model of HIV-1 latency. • Reactivation is synergized when oxaliplatin is used in combination with valproic acid. • Oxaliplatin reactivates latent HIV-1 through activation of NF-kB and does not induce T cell activation. - Abstract: Reactivation of latent HIV-1 is a promising strategy for the clearance of the viral reservoirs. Because of the limitations of current agents, identification of new latency activators is urgently required. Using an established model of HIV-1 latency, we examined the effect of Oxaliplatin on latent HIV-1 reactivation. We showed that Oxaliplatin, alone or in combination with valproic acid (VPA), was able to reactivate HIV-1 without inducing global T cell activation. We also provided evidence that Oxaliplatin reactivated HIV-1 expression by inducing nuclear factor kappa B (NF-κB) nuclear translocation. Our results indicated that Oxaliplatin could be a potential drug candidate for anti-latency therapies.

  10. Deactivation Management

    Energy.gov [DOE]

    The purpose here is to provide information for specific aspects of project management that apply to deactivation. Overall management of deactivation projects should use a traditional project...

  11. Conference Management

    Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-11-03

    To establish requirements and responsibilities with respect to managing conferences sponsored by the Department of Energy (DOE) or by DOE management and operating contractors and other contractors who perform work at DOE-owned or -leased facilities, including management and integration contractors and environmental restoration management contractors (when using funds that will be reimbursed by DOE). Cancels DOE N 110.3.

  12. Urotensin II increases foam cell formation by repressing ABCA1 expression through the ERK/NF-κB pathway in THP-1 macrophages

    SciTech Connect (OSTI)

    Wang, Yan; Wu, Jian-Feng; Tang, Yan-Yan; Zhang, Min; Li, Yuan; Chen, Kong; Zeng, Meng-Ya; Yao, Feng; Xie, Wei; Zheng, Xi-Long; Zeng, Gao-Feng; Tang, Chao-Ke

    2014-10-03

    Highlights: • U II reduces cholesterol efflux in THP-1 macrophages. • U II decreases the expression of ABCA1. • Inhibition of the ERK/NF-κB pathway reduces U II effects on ABCA1 expression and cholesterol efflux. - Abstract: Objective: Foam cell formation in the arterial wall plays a key role in the development of atherosclerosis. Recent studies showed that Urotensin II (U II) is involved in the pathogenesis of atherosclerosis. Here we examined the effects of human U II on ATP-binding cassette transporter A1 (ABCA1) expression and the underlying mechanism in THP-1 macrophages. Methods and results: Cultured THP-1 macrophages were treated with U II, followed by measuring the intracellular lipid contents, cholesterol efflux and ABCA1 levels. The results showed that U II dramatically decreased ABCA1 levels and impaired cholesterol efflux. However, the effects of U II on ABCA1 protein expression and cellular cholesterol efflux were partially reversed by inhibition of extracellular signal regulated kinase 1/2 (ERK1/2) and nuclear factor kappa B (NF-κB) activity, suggesting the potential roles of ERK1/2 and NF-κB in ABCA1 expression, respectively. Conclusion: Our current data indicate that U II may have promoting effects on the progression of atherosclerosis, likely through suppressing ABCA1 expression via activation of the ERK/NF-κB pathway and reducing cholesterol efflux to promote macrophage foam cell formation.

  13. Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

    SciTech Connect (OSTI)

    Verhaak, Roel GW; Hoadley, Katherine A; Purdom, Elizabeth; Wang, Victoria; Qi, Yuan; Wilkerson, Matthew D; Miller, C Ryan; Ding, Li; Golub, Todd; Mesirov, Jill P; Alexe, Gabriele; Lawrence, Michael; O'Kelly, Michael; Tamayo, Pablo; Weir, Barbara A; Gabriel, Stacey; Winckler, Wendy; Gupta, Supriya; Jakkula, Lakshmi; Feiler, Heidi S; Hodgson, J Graeme; James, C David; Sarkaria, Jann N; Brennan, Cameron; Kahn, Ari; Spellman, Paul T; Wilson, Richard K; Speed, Terence P; Gray, Joe W; Meyerson, Matthew; Getz, Gad; Perou, Charles M; Hayes, D Neil; Network, The Cancer Genome Atlas Research

    2009-09-03

    The Cancer Genome Atlas Network recently cataloged recurrent genomic abnormalities in glioblastoma multiforme (GBM). We describe a robust gene expression-based molecular classification of GBM into Proneural, Neural, Classical, and Mesenchymal subtypes and integrate multidimensional genomic data to establish patterns of somatic mutations and DNA copy number. Aberrations and gene expression of EGFR, NF1, and PDGFRA/IDH1 each define the Classical, Mesenchymal, and Proneural subtypes, respectively. Gene signatures of normal brain cell types show a strong relationship between subtypes and different neural lineages. Additionally, response to aggressive therapy differs by subtype, with the greatest benefit in the Classical subtype and no benefit in the Proneural subtype. We provide a framework that unifies transcriptomic and genomic dimensions for GBM molecular stratification with important implications for future studies.

  14. Metastatic function of BMP-2 in gastric cancer cells: The role of PI3K/AKT, MAPK, the NF-{kappa}B pathway, and MMP-9 expression

    SciTech Connect (OSTI)

    Kang, Myoung Hee; Oh, Sang Cheul; Kang, Han Na; Kim, Jung Lim; Kim, Jun Suk

    2011-07-15

    Bone morphogenetic proteins (BMPs) have been implicated in tumorigenesis and metastatic progression in various types of cancer cells, but the role and cellular mechanism in the invasive phenotype of gastric cancer cells is not known. Herein, we determined the roles of phosphoinositide 3-kinase (PI3K)/AKT, extracellular signal-regulated protein kinase (ERK), nuclear factor (NF)-{kappa}B, and matrix metalloproteinase (MMP) expression in BMP-2-mediated metastatic function in gastric cancer. We found that stimulation of BMP-2 in gastric cancer cells enhanced the phosphorylation of AKT and ERK. Accompanying activation of AKT and ERK kinase, BMP-2 also enhanced phosphorylation/degradation of I{kappa}B{alpha} and the nuclear translocation/activation of NF-{kappa}B. Interestingly, blockade of PI3K/AKT and ERK signaling using LY294002 and PD98059, respectively, significantly inhibited BMP-2-induced motility and invasiveness in association with the activation of NF-{kappa}B. Furthermore, BMP-2-induced MMP-9 expression and enzymatic activity was also significantly blocked by treatment with PI3K/AKT, ERK, or NF-{kappa}B inhibitors. Immunohistochemistry staining of 178 gastric tumor biopsies indicated that expression of BMP-2 and MMP-9 had a significant positive correlation with lymph node metastasis and a poor prognosis. These results indicate that the BMP-2 signaling pathway enhances tumor metastasis in gastric cancer by sequential activation of the PI3K/AKT or MAPK pathway followed by the induction of NF-{kappa}B and MMP-9 activity, indicating that BMP-2 has the potential to be a therapeutic molecular target to decrease metastasis.

  15. Nuclear NF-?B Expression Correlates With Outcome Among Patients With Head and Neck Squamous Cell Carcinoma Treated With Primary Chemoradiation Therapy

    SciTech Connect (OSTI)

    Balermpas, Panagiotis [Department of Radiation Therapy and Oncology, J. W. Goethe University Frankfurt am Main, Frankfurt (Germany)] [Department of Radiation Therapy and Oncology, J. W. Goethe University Frankfurt am Main, Frankfurt (Germany); Michel, Yvonne [Senckenberg Institute of Pathology, J. W. Goethe University Frankfurt am Main, Frankfurt (Germany)] [Senckenberg Institute of Pathology, J. W. Goethe University Frankfurt am Main, Frankfurt (Germany); Wagenblast, Jens [Department of Otorhinolaryngology, J. W. Goethe University Frankfurt am Main, Frankfurt (Germany)] [Department of Otorhinolaryngology, J. W. Goethe University Frankfurt am Main, Frankfurt (Germany); Seitz, Oliver [Department of Maxillofacial Surgery, J. W. Goethe University Frankfurt am Main, Frankfurt (Germany)] [Department of Maxillofacial Surgery, J. W. Goethe University Frankfurt am Main, Frankfurt (Germany); Sipek, Florian; Rdel, Franz; Rdel, Claus [Department of Radiation Therapy and Oncology, J. W. Goethe University Frankfurt am Main, Frankfurt (Germany)] [Department of Radiation Therapy and Oncology, J. W. Goethe University Frankfurt am Main, Frankfurt (Germany); Fokas, Emmanouil, E-mail: emmanouil.fokas@kgu.de [Department of Radiation Therapy and Oncology, J. W. Goethe University Frankfurt am Main, Frankfurt (Germany)] [Department of Radiation Therapy and Oncology, J. W. Goethe University Frankfurt am Main, Frankfurt (Germany)

    2013-07-15

    Background: To examine whether nuclear NF-?B expression correlates with outcome in patients with head and neck squamous cell carcinoma (HNSCC) treated with primary chemoradiation therapy (CRT). Methods and Materials: Between 2007 and 2010, 101 patients with locally advanced primary HNSCC were treated with definitive simultaneous CRT. Pretreatment biopsy specimens were analyzed for NF-?B p65 (RelA) nuclear immunoreactivity. A sample was assigned to be positive with more than 5% positive nuclear expression. The predictive relevance of NF-?B and clinicopathologic factors for overall survival (OS), progression-free survival (PFS), local progression-free survival (LPFS), and metastasis-free survival (DMFS) was examined by univariate and multivariate analysis. Results: No significant differences between the groups were observed with regard to age, sex, total radiation dose, fractionation mode, total chemotherapy applied, T stage or grading. Patients with p65 nuclear positive biopsy specimens showed significantly a higher rate of lymph node metastasis (cN2c or cN3 status, P=.034). Within a mean follow-up time of 25 months (range, 2.33-62.96 months) OS, PFS, and DMFS were significantly poorer in the p65 nuclear positive group (P=.008, P=.027, and P=.008, respectively). These correlations remained significant in multivariate analysis. Conclusion: NF-?B/p65 nuclear expression is associated with increased lymphatic and hematogenous tumor dissemination and decreased survival in HNSCC patients treated with primary CRT. Our results may foster further investigation of a predictive relevance of NF-?B/p65 and its role as a suitable target for a molecular-based targeted therapy in HNSCC cancer.

  16. MANAGEMENT ALERT

    Energy.gov (indexed) [DOE]

    COMMISSION FROM: Gregory H. Friedman Inspector General SUBJECT: INFORMATION: Management Alert: Review of Allegations of Improper Disclosure of Confidential, Nonpublic...

  17. DEACTIVATION MANAGEMENT

    Office of Environmental Management (EM)

    MANAGEMENT The purpose here is to provide information for specific aspects of project management that apply to deactivation. Overall management of deactivation projects should use a traditional project management approach, and as such is not addressed. The following specific topics are based on lessons learned during deactivation of DOE facilities.  The Deactivation Mission  The Stabilization/Deactivation "Customer"  Project Approach for a Complex Facility  Establishing the

  18. Environmental Management Waste Management Facility (EMWMF) at...

    Office of Environmental Management (EM)

    Review of the Environmental Management Waste Management Facility (EMWMF) at Oak Ridge ... INTRODUCTION The Environmental Management Waste Management Facility (EMWMF) is a land ...

  19. Coactivation of the PI3K/Akt and ERK signaling pathways in PCB153-induced NF-κB activation and caspase inhibition

    SciTech Connect (OSTI)

    Liu, Changjiang; Yang, Jixin; Fu, Wenjuan; Qi, Suqin; Wang, Chenmin; Quan, Chao; Yang, Kedi

    2014-06-15

    Polychlorinated biphenyls (PCBs) are a group of persistent and widely distributed environmental pollutants that have various deleterious effects, e.g., neurotoxicity, endocrine disruption and reproductive abnormalities. In order to verify the hypothesis that the PI3K/Akt and MAPK pathways play important roles in hepatotoxicity induced by PCBs, Sprague–Dawley (SD) rats were dosed with PCB153 intraperitoneally at 0, 4, 16 and 32 mg/kg for five consecutive days; BRL cells (rat liver cell line) were treated with PCB153 (0, 1, 5, and 10 μM) for 24 h. Results indicated that the PI3K/Akt and ERK pathways were activated in vivo and in vitro after exposure to PCB153, and protein levels of phospho-Akt and phospho-ERK were significantly increased. Nuclear factor-κB (NF-κB) activation and caspase-3, -8 and -9 inhibition caused by PCB153 were also observed. Inhibiting the ERK pathway significantly attenuated PCB153-induced NF-κB activation, whereas inhibiting the PI3K/Akt pathway hardly influenced phospho-NF-κB level. However, inhibiting the PI3K/Akt pathway significantly elevated caspase-3, -8 and -9 activities, while the ERK pathway only synergistically regulated caspase-9. Proliferating cell nuclear antigen (PCNA), a reliable indicator of cell proliferation, was also induced. Moreover, PCB153 led to hepatocellular hypertrophy and elevated liver weight. Taken together, PCB153 leads to aberrant proliferation and apoptosis of hepatocytes through NF-κB activation and caspase inhibition, and coactivated PI3K/Akt and ERK pathways play critical roles in PCB153-induced hepatotoxicity. - Highlights: • PCB153 led to hepatotoxicity through NF-κB activation and caspase inhibition. • The PI3K/Akt and ERK pathways were coactivated in vivo and in vitro by PCB153. • The ERK pathway regulated levels of phospho-NF-κB and caspase-9. • The PI3K/Akt pathway regulated levels of caspase-3, -8 and -9.

  20. Teaching Managers How to Manage

    SciTech Connect (OSTI)

    Hylko, J.M.

    2006-07-01

    Following graduation from a college or university with a technical degree, or through years of experience, an individual's training and career development activities typically focus on enhancing technical problem-solving skills. However, as these technical professionals, herein referred to as 'Techies', advance throughout their careers, they may be required to accept and adapt to the role of being a manager, and must undergo a transition to learn and rely on new problem-solving skills. However, unless a company has a specific manager-trainee class to address this subject and develop talent from within, an employee's management style is learned and developed 'on the job'. Both positive and negative styles are nurtured by those managers having similar qualities. Unfortunately, a negative style often contributes to the deterioration of employee morale and ultimate closing of a department or company. This paper provides the core elements of an effective management training program for 'Teaching Managers How to Manage' derived from the Department of Energy's Integrated Safety Management System and the Occupational Safety and Health Administration 's Voluntary Protection Program. Discussion topics and real-life examples concentrate on transitioning an employee from a 'Techie' to a manager; common characteristics of being a manager; the history and academic study of management; competition, change and the business of waste management; what to do after taking over a department by applying Hylko's Star of Success; command media; the formal and informal organizational charts; chain of command; hiring and developing high-degree, autonomous employees through effective communication and delegation; periodic status checks; and determining if the program is working successfully. These common characteristics of a strong management/leadership culture and practical career tips discussed herein provide a solid foundation for any company or department that is serious about developing

  1. Bibliographic Management

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    and more from varied resources and databases to organize references, keep notes to stay ahead of the game. Questions? 505-667-5809 Email Bibliographic management tools allow...

  2. acquisition management

    National Nuclear Security Administration (NNSA)

    the science, technology, and engineering base; and,

  3. Continue NNSA management reforms.


    • Our Values:<...

    • Deputy Manager

      Energy.gov [DOE]

      A successful candidate in this position will support the Oak Ridge Office (ORO) Manager by providing overall executive leadership to ORO.

    • Position Management

      Directives, Delegations, and Requirements [Office of Management (MA)]

      1992-06-23

      The order prescribes the policies, responsibilities, and procedures for position management within (DOE). Canceled by DOE N 1321.140. Cancels DOE 3510.1

    • Management Overview

      U.S. Department of Energy (DOE) all webpages (Extended Search)

      Debrief for the DOE-Managed Spent Nuclear Fuel and High Level Waste Research (aka Defense ... of "single repository" policy, whereby defense-related and commercial wastes are ...

    • project management

      National Nuclear Security Administration (NNSA)

      %2A en Project Management and Systems Support http:nnsa.energy.govaboutusouroperationsapmprojectmanagementandsystemssupport

    • Energy Management

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      Energy Management Utilize energy efficiency to improve your industrial customer's business performance without the cost of major capital improvements. Energy efficiency is not...

    • project management

      National Nuclear Security Administration (NNSA)

      3%2A en Project Management and Systems Support http:www.nnsa.energy.govaboutusouroperationsapmprojectmanagementandsystemssupport

    • Quality Management

      Energy.gov [DOE]

      The Office of Quality Management, within the Office of Health, Safety and Security develops policies and procedures to ensure the classification and control of information is effective and...

    • Moderate extracellular acidification inhibits capsaicin-induced cell death through regulating calcium mobilization, NF-{kappa}B translocation and ROS production in synoviocytes

      SciTech Connect (OSTI)

      Hu, Fen; Yang, Shuang; Zhao, Dan; Zhu, Shuyan; Wang, Yuxiang; Li, Junying

      2012-07-20

      Highlights: Black-Right-Pointing-Pointer Moderate extracellular acidification regulates intracellular Ca{sup 2+} mobilization. Black-Right-Pointing-Pointer Moderate acidification activates NF-{kappa}B nuclear translocation in synoviocytes. Black-Right-Pointing-Pointer Moderate acidification depresses the ROS production induced by capsaicin. Black-Right-Pointing-Pointer Moderate acidification inhibits capsaicin-caused synoviocyte death. -- Abstract: We previously show the expression of transient receptor potential vanilloid 1 (TRPV1) in primary synoviocytes from collagen-induced arthritis (CIA) rats. Capsaicin and lowered extracellular pH from 7.4 to 5.5 induce cell death through TRPV1-mediated Ca{sup 2+} entry and reactive oxygen species (ROS) production. However, under the pathological condition in rheumatoid arthritis, the synovial fluid is acidified to a moderate level (about pH 6.8). In the present study, we examined the effects of pH 6.8 on the TRPV1-mediated cell death. Our finding is different or even opposite from what was observed at pH 5.5. We found that the moderate extracellular acidification (from pH 7.4 to 6.8) inhibited the capsaicin-induced Ca{sup 2+} entry through attenuating the activity of TRPV1. In the mean time, it triggered a phospholipse C (PLC)-related Ca{sup 2+} release from intracellular stores. The nuclear translocation of NF-{kappa}B was found at pH 6.8, and this also depends on PLC activation. Moreover, the capsaicin-evoked massive ROS production and cell death were depressed at pH 6.8, both of which are dependent on the activation of PLC and NF-{kappa}B. Taken together, these results suggested that the moderate extracellular acidification inhibited the capsaicin-induced synoviocyte death through regulating Ca{sup 2+} mobilization, activating NF-{kappa}B nuclear translocation and depressing ROS production.

    • Sargahydroquinoic acid inhibits TNFα-induced AP-1 and NF-κB signaling in HaCaT cells through PPARα activation

      SciTech Connect (OSTI)

      Jeon, Youngsic; Jung, Yujung; Kim, Min Cheol; Kwon, Hak Cheol; Kang, Ki Sung; Kim, Yong Kee; Kim, Su-Nam

      2014-08-08

      Highlights: • SHQA increases PPARα/γ transactivation and inhibits MMP-2/-9 expression. • SHQA inhibits TNFα-induced AP-1 and MAPK signaling. • SHQA inhibits TNFα-induced p65 translocation and IκBα phosphorylation. • SHQA inhibits TNFα-induced AP-1 and NF-κB signaling via PPARα. - Abstract: Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors and expressed in various cell types in the skin, including keratinocytes, fibroblasts and infiltrating immune cells. Thus, their ligands are targets for the treatment of various skin disorders, such as photo-aging and chronological aging of skin. Intensive studies have revealed that PPARα/γ functions in photo-aging and age-related inflammation by regulating matrix metalloproteinases (MMPs) via activator protein-1 (AP-1) and nuclear factor kappa B (NF-κB). However, the detailed mechanism of PPARα/γ’s role in skin aging has not yet been elucidated. In this study, we confirmed that sargahydroquinoic acid (SHQA) as a PPARα/γ ligand significantly decreased Tumor Necrosis Factor-alpha (TNFα)-induced MMP-2/-9 expression by downregulating TNFα-induced transcription factors, subsequently reducing IκBα degradation and blocking NF-κB p65 nuclear translocation in HaCaT human epidermal keratinocyte cells. Treatment of cells with SHQA and GW6471 (PPARα antagonist) not bisphenol A diglycidyl ether (PPARγ antagonists), reversed the effect on TNFα-induced inflammatory signaling pathway activation. Taken together, our data suggest that SHQA inhibit TNFα-induced MMP-2/-9 expression and age-related inflammation by suppressing AP-1 and NF-κB pathway via PPARα.

    • Gastrodin stimulates anticancer immune response and represses transplanted H22 hepatic ascitic tumor cell growth: Involvement of NF-?B signaling activation in CD4 + T cells

      SciTech Connect (OSTI)

      Shu, Guangwen; Yang, Tianming; Wang, Chaoyuan; Su, Hanwen; Xiang, Meixian

      2013-06-15

      Gastrodia elata Blume (G. elata) is a famous restorative food in East Asia. It can be used as an auxiliary reagent in hepatocellular carcinoma (HCC) treatment. Previous studies unveiled that G. elata exhibited immunomodulatory activities. To explore the active ingredients contributing to its immunomodulatory activities, gastrodin, vanillin, and parishin B were purified from G. elata and their anti-HCC effects were assessed in vivo. Among these compounds, only gastrodin was capable of repressing transplanted H22 ascitic hepatic tumor cell growth in vivo with low toxicity. Further investigations were designed to explore the effects of gastrodin on the immune system of tumor-bearing mice and potential molecular mechanisms underlying these effects. Our data showed that gastrodin ameliorated tumor cell transplantation-induced activation of endogenous pro-apoptotic pathway in CD4 + T cells and abnormalities in serum cytokine profiles in host animals. These events enhanced cytotoxic activities of natural killer and CD8 + T cells against H22 hepatic cancer cells. Gastrodin administration specifically upregulated mRNA levels of several nuclear factor ?B (NF-?B) responsive genes in CD4 + T cells but not in CD8 + T cells. Chromatin immunoprecipitation assay showed that gastrodin increased the association of NF-?B p65 subunit to the promoter regions of IL-2 and Bcl-2 encoding genes in CD4 + T cells. Our investigations demonstrated that gastrodin is the main active ingredient contributing to the anticancer immunomodulatory properties of G. elata. Promoting NF-?B-mediated gene transcription in CD4 + T cells is implicated in its immunomodulatory activity. - Highlights: Gastrodin stimulates anticancer immune response. Gastrodin represses tumor transplantation-induced CD4 + T cell apoptosis. Gastrodin activates NF-?B activity in CD4 + T cells.

    • Stevioside ameliorates high-fat diet-induced insulin resistance and adipose tissue inflammation by downregulating the NF-{kappa}B pathway

      SciTech Connect (OSTI)

      Wang, Zhiquan; Xue, Liqiong; Guo, Cuicui; Han, Bing; Pan, Chunming; Zhao, Shuangxia; Song, Huaidong; Ma, Qinyun

      2012-01-27

      Highlights: Black-Right-Pointing-Pointer Stevioside ameliorates high-fat diet-induced insulin resistance. Black-Right-Pointing-Pointer Stevioside alleviates the adipose tissue inflammation. Black-Right-Pointing-Pointer Stevioside reduces macrophages infiltration into the adipose tissue. Black-Right-Pointing-Pointer Stevioside suppresses the activation of NF-{kappa}B in the adipose tissue. -- Abstract: Accumulating evidence suggests that adipose tissue is the main source of pro-inflammatory molecules that predispose individuals to insulin resistance. Stevioside (SVS) is a widely used sweetener with multiple beneficial effects for diabetic patients. In this study, we investigated the effect of SVS on insulin resistance and the pro-inflammatory state of adipose tissue in mice fed with a high-fat diet (HFD). Oral administration of SVS for 1 month had no effect on body weight, but it significantly improved fasting glucose, basal insulin levels, glucose tolerance and whole body insulin sensitivity. Interestingly, these changes were accompanied with decreased expression levels of several inflammatory cytokines in adipose tissue, including TNF-{alpha}, IL6, IL10, IL1{beta}, KC, MIP-1{alpha}, CD11b and CD14. Moreover, macrophage infiltration in adipose tissue was remarkably reduced by SVS. Finally, SVS significantly suppressed the nuclear factor-kappa b (NF-{kappa}B) signaling pathway in adipose tissue. Collectively, these results suggested that SVS may ameliorate insulin resistance in HFD-fed mice by attenuating adipose tissue inflammation and inhibiting the NF-{kappa}B pathway.

    • ROS and NF-{kappa}B are involved in upregulation of IL-8 in A549 cells exposed to multi-walled carbon nanotubes

      SciTech Connect (OSTI)

      Ye Shefang Wu Yihui; Hou Zhenqing; Zhang Qiqing

      2009-02-06

      Carbon nanotubes (CNTs) have potential applications in biosensors, tissue engineering, and biomedical devices because of their unique physico-chemical, electronic and mechanical properties. However, there is limited literature data available concerning the biological properties and toxicity of CNTs. This study aimed to assess the toxicity exhibited by multi-walled CNTs (MWCNTs) and to elucidate possible molecular mechanisms underlying the biological effects of MWCNTs in A549 cells. Exposing A549 cells to MWCNTs led to cell death, changes in cell size and complexity, reactive oxygen species (ROS) production, interleukin-8 (IL-8) gene expression and nuclear factor (NF)-{kappa}B activation. Treatment of A549 cells with antioxidants prior to adding MWCNTs decreased ROS production and abrogated expression of IL-8 mRNA. Pretreatment of A549 cells with NF-{kappa}B inhibitors suppressed MWCNTs-induced IL-8 mRNA expression. These results indicate that MWCNTs are able to induce expression of IL-8 in A549 cells, at least in part, mediated by oxidative stress and NF-{kappa}B activation.

    • Neutron and proton electric dipole moments from Nf=2+1 domain-wall fermion lattice QCD

      DOE PAGES-Beta [OSTI]

      Shintani, Eigo; Blum, Thomas; Izubuchi, Taku; Soni, Amarjit

      2016-05-05

      We present a lattice calculation of the neutron and proton electric dipole moments (EDM’s) with Nf = 2 + 1 flavors of domain-wall fermions. The neutron and proton EDM form factors are extracted from three-point functions at the next-to-leading order in the θ vacuum of QCD. In this computation, we use pion masses 330 and 420 MeV and 2.7 fm3 lattices with Iwasaki gauge action and a 170 MeV pion and 4.6 fm3 lattice with I-DSDR gauge action, all generated by the RBC and UKQCD collaborations. The all-mode-averaging technique enables an efficient, high statistics calculation; however the statistical errors onmore » our results are still relatively large, so we investigate a new direction to reduce them, reweighting with the local topological charge density which appears promising. Furthermore, we discuss the chiral behavior and finite size effects of the EDM’s in the context of baryon chiral perturbation theory.« less

    • Ascorbic acid suppresses endotoxemia and NF-κB signaling cascade in alcoholic liver fibrosis in guinea pigs: A mechanistic approach

      SciTech Connect (OSTI)

      Abhilash, P.A.; Harikrishnan, R.; Indira, M.

      2014-01-15

      Alcohol consumption increases the small intestinal bacterial overgrowth (SIBO) and intestinal permeability of endotoxin. The endotoxin mediated inflammatory signaling plays a major role in alcoholic liver fibrosis. We evaluated the effect of ascorbic acid (AA), silymarin and alcohol abstention on the alcohol induced endotoxemia and NF-κB activation cascade pathway in guinea pigs (Cavia porcellus). Guinea pigs were administered ethanol at a daily dose of 4 g/kg b.wt for 90 days. After 90 days, ethanol administration was stopped. The ethanol treated animals were divided into abstention, silymarin (250 mg/kg b.wt) and AA (250 mg/kg b.wt) supplemented groups and maintained for 30 days. The SIBO, intestinal permeability and endotoxin were significantly increased in the ethanol group. The mRNA expressions of intestinal proteins claudin, occludin and zona occludens-1 were significantly decreased in ethanol group. The mRNA levels of inflammatory receptors, activity of IKKβ and the protein expressions of phospho-IκBα, NF-κB, TNF-α, TGF-β{sub 1} and IL-6 were also altered in ethanol group. The expressions of fibrosis markers α-SMA, α{sub 1} (I) collagen and sirius red staining in the liver revealed the induction of fibrosis. But the supplementation of AA could induce greater reduction of ethanol induced SIBO, intestinal barrier defects, NF-κB activation and liver fibrosis than silymarin. The possible mechanism may be the inhibitory effect of AA on SIBO, intestinal barrier defect and IKKβ, which decreased the activation of NF-κB and synthesis of cytokines. This might have led to suppression of HSCs activation and liver fibrosis. - Highlights: • Alcohol increases intestinal bacterial overgrowth and permeability of endotoxin. • Endotoxin mediated inflammation plays a major role in alcoholic liver fibrosis. • Ascorbic acid reduces endotoxemia, NF-κB activation and proinflammatory cytokines. • AA's action is by inhibition of SIBO, IKKβ and alteration of

    • Management Overview

      U.S. Department of Energy (DOE) all webpages (Extended Search)

      ... Disposition R&D Campaign FY17 Planning Used Fuel Disposition Schedule for FY17 Planning June 2016: Campaign management works with NE-53 to prepare FY17 plan at the control ...

    • Conference Management

      Directives, Delegations, and Requirements [Office of Management (MA)]

      2007-01-25

      The Order establishes requirements and responsibilities for managing conferences sponsored or co-sponsored by the Department of Energy, including the National Nuclear Security Administration. Cancels DOE O 110.3. Canceled by DOE N 251.97.

    • Summary - Environmental Management Waste Management Facility...

      Office of Environmental Management (EM)

      Waste Management Facility (EMWMF) at Oak Ridge, TN Why DOE-EM Did This Review The Environmental Management Waste Management Facility (EMWMF) is a land disposal facility for ...

    • PROJECT MANAGEMENT PLANS Project Management Plans

      Office of Environmental Management (EM)

      MANAGEMENT PLANS Project Management Plans Overview Project Management Plan Suggested Outline Subjects Crosswalk between the Suggested PMP Outline Subjects and a Listing ...

  1. Environmental Management Waste Management Facility (EMWMF) at...

    Office of Environmental Management (EM)

    Waste Management Facility (EMWMF) at Oak Ridge Environmental Management Waste Management Facility (EMWMF) at Oak Ridge Full Document and Summary Versions are available for download ...

  2. Program Managers

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Program Managers Program Managers Enabling remarkable discoveries and tools that transform our understanding of energy and matter and advance national, economic, and energy security. Advanced Scientific Computing Applied Mathematics: Pieter Swart, T-5 Computer Science: Pat McCormick, CCS-7 Computational Partnerships: Galen Shipman, CCS-7 Basic Energy Sciences Materials Sciences & Engineering: Toni Taylor, ADCLES-DO CINT National User Facility: Alex Lacerda, MPA-CINT (Acting Director)

  3. Mangiferin exerts hepatoprotective activity against D-galactosamine induced acute toxicity and oxidative/nitrosative stress via Nrf2NF?B pathways

    SciTech Connect (OSTI)

    Das, Joydeep; Ghosh, Jyotirmoy; Roy, Anandita; Sil, Parames C.

    2012-04-01

    Mangiferin, a xanthone glucoside, is well known to exhibit antioxidant, antiviral, antitumor, anti-inflammatory and gene-regulatory effects. In the present study, we isolated mangiferin from the bark of Mangifera indica and assessed its beneficial role in galactosamine (GAL) induced hepatic pathophysiology. GAL (400 mg/kg body weight) exposed hepatotoxic rats showed elevation in the activities of serum ALP, ALT, levels of triglycerides, total cholesterol, lipid-peroxidation and reduction in the levels of serum total proteins, albumin and cellular GSH. Besides, GAL exposure (5 mM) in hepatocytes induced apoptosis and necrosis, increased ROS and NO production. Signal transduction studies showed that GAL exposure significantly increased the nuclear translocation of NF?B and elevated iNOS protein expression. The same exposure also elevated TNF-?, IFN-?, IL-1?, IL-6, IL-12, IL-18 and decreased IL-10 mRNA expressions. Furthermore, GAL also decreased the protein expression of Nrf2, NADPH:quinine oxidoreductase-1, heme oxygenase-1 and GST?. However, mangiferin administration in GAL intoxicated rats or coincubation of hepatocytes with mangiferin significantly altered all these GAL-induced adverse effects. In conclusion, the hepatoprotective role of mangiferin was due to induction of antioxidant defense via the Nrf2 pathway and reduction of inflammation via NF?B inhibition. Highlights: ?Galactosamine induces hepatocytes death via oxidative and nitrosative stress. ?Mangiferin exerts hepatoprotective effect/antioxidant defense via Nrf2 pathway. ?Mangiferin exerts anti-inflammatory responses by inhibiting NF-?B. ?Mangiferin suppresses galactosamine-induced repression of IL-10 mRNA.

  4. Celastrol ameliorates HIV-1 Tat-induced inflammatory responses via NF-kappaB and AP-1 inhibition and heme oxygenase-1 induction in astrocytes

    SciTech Connect (OSTI)

    Youn, Gi Soo; Kwon, Dong-Joo; Ju, Sung Mi; Rhim, Hyangshuk; Bae, Yong Soo; Choi, Soo Young; Park, Jinseu

    2014-10-01

    HIV-1 Tat causes extensive neuroinflammation that may progress to AIDS-related encephalitis and dementia. Celastrol possesses various biological activities such as anti-oxidant, anti-tumor, and anti-inflammatory activities. In this study, we investigated the modulatory effects of celastrol on HIV-1 Tat-induced inflammatory responses and the molecular mechanisms underlying its action in astrocytes. Pre-treatment of CRT-MG human astroglioma cells with celastrol significantly inhibited HIV-1 Tat-induced expression of ICAM-1/VCAM-1 and subsequent monocyte adhesiveness in CRT-MG cells. In addition, celastrol suppressed HIV-1 Tat-induced expression of pro-inflammatory chemokines, such as CXCL10, IL-8, and MCP-1. Celastrol decreased HIV-1 Tat-induced activation of JNK MAPK, AP-1, and NF-κB. Furthermore, celastrol induced mRNA and protein expression of HO-1 as well as Nrf2 activation. Blockage of HO-1 expression using siRNA reversed the inhibitory effect of celastrol on HIV-1 Tat-induced inflammatory responses. These results suggest that celastrol has regulatory effects on HIV-1 Tat-induced inflammatory responses by blocking the JNK MAPK-AP-1/NF-κB signaling pathways and inducing HO-1 expression in astrocytes. - Highlights: • Celastrol suppressed HIV-1 Tat-induced expression of pro-inflammatory genes. • Celastrol inhibited HIV-1 Tat -induced activation of JNK MAPK. • Celastrol inhibited HIV-1 Tat-induced activation of both NF-κB and AP-1. • Celastrol inhibited HIV-1 Tat-induced inflammatory responses via HO-1 induction.

  5. The plant limonoid 7-oxo-deacetoxygedunin inhibits RANKL-induced osteoclastogenesis by suppressing activation of the NF-{kappa}B and MAPK pathways

    SciTech Connect (OSTI)

    Wisutsitthiwong, Chonnaree; Buranaruk, Chayanit; Pudhom, Khanitha; Palaga, Tanapat

    2011-11-18

    Highlights: Black-Right-Pointing-Pointer A gedunin type limonoid from seeds of mangroves, 7-oxo-7-deacetoxygedunin, exhibits strong anti-osteoclastogenic activity. Black-Right-Pointing-Pointer Treatment with this limonoid results in significant decrease in expression of NFATc1 and osteoclast-related genes. Black-Right-Pointing-Pointer The mode of action of this limonoid is by inhibiting activation of the NF-{kappa}B and MAPK pathways which are activated by RANKL. -- Abstract: Osteoclasts together with osteoblasts play pivotal roles in bone remodeling. Aberrations in osteoclast differentiation and activity contribute to osteopenic disease. Osteoclasts differentiate from monocyte/macrophage progenitors, a process that is initiated by the interaction between receptor activator of NF-{kappa}B (RANK) and its ligand, RANKL. In this study, we identified 7-oxo-7-deacetoxygedunin (7-OG), a gedunin type limonoid from seeds of the mangrove Xylocarpus moluccensis, as a potent inhibitor of osteoclastogenesis. Additionally, 7-OG showed strong anti-osteoclastogenic activity with low cytotoxicity against the monocyte/macrophage progenitor cell line, RAW264.7. The IC50 for anti-osteoclastogenic activity was 4.14 {mu}M. Treatment with 7-OG completely abolished the appearance of multinucleated giant cells with tartrate-resistant acid phosphatase activity in RAW264.7 cells stimulated with RANKL. When the expression of genes related to osteoclastogenesis was investigated, a complete downregulation of NFATc1 and cathepsin K and a delayed downregulation of irf8 were observed upon 7-OG treatment in the presence of RANKL. Furthermore, treatment with this limonoid suppressed RANKL-induced activation of p38, MAPK and Erk and nuclear localization of NF-{kappa}B p65. Taken together, we present evidence indicating a plant limonoid as a novel osteoclastogenic inhibitor that could be used for osteoporosis and related conditions.

  6. Tat-CBR1 inhibits inflammatory responses through the suppressions of NF-κB and MAPK activation in macrophages and TPA-induced ear edema in mice

    SciTech Connect (OSTI)

    Kim, Young Nam; Kim, Dae Won; Jo, Hyo Sang; Shin, Min Jea; Ahn, Eun Hee; Ryu, Eun Ji; Yong, Ji In; Cha, Hyun Ju; Kim, Sang Jin; Yeo, Hyeon Ji; Youn, Jong Kyu; Hwang, Jae Hyeok; Jeong, Ji-Heon; Kim, Duk-Soo; Cho, Sung-Woo; Park, Jinseu; Eum, Won Sik; Choi, Soo Young

    2015-07-15

    Human carbonyl reductase 1 (CBR1) plays a crucial role in cell survival and protects against oxidative stress response. However, its anti-inflammatory effects are not yet clearly understood. In this study, we examined whether CBR1 protects against inflammatory responses in macrophages and mice using a Tat-CBR1 protein which is able to penetrate into cells. The results revealed that purified Tat-CBR1 protein efficiently transduced into Raw 264.7 cells and inhibited lipopolysaccharide (LPS)-induced cyclooxygenase-2 (COX-2), nitric oxide (NO) and prostaglandin E{sub 2} (PGE{sub 2}) expression levels. In addition, Tat-CBR1 protein leads to decreased pro-inflammatory cytokine expression through suppression of nuclear transcription factor-kappaB (NF-κB) and mitogen activated protein kinase (MAPK) activation. Furthermore, Tat-CBR1 protein inhibited inflammatory responses in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation when applied topically. These findings indicate that Tat-CBR1 protein has anti-inflammatory properties in vitro and in vivo through inhibition of NF-κB and MAPK activation, suggesting that Tat-CBR1 protein may have potential as a therapeutic agent against inflammatory diseases. - Highlights: • Transduced Tat-CBR1 reduces LPS-induced inflammatory mediators and cytokines. • Tat-CBR1 inhibits MAPK and NF-κB activation. • Tat-CBR1 ameliorates inflammation response in vitro and in vivo. • Tat-CBR1 may be useful as potential therapeutic agent for inflammation.

  7. Data Management

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Data Management Data Management Archiving your data with HPSS These are some basic examples of data transfer and access with HPSS. Access Example Using HSI from a NERSC Production System All of the NERSC computational systems available to users have the hsi client already installed. To access the Archive storage system you can type hsi with no arguments: % hsi That is, the utility is set up to connect to the Archive system by default. This is equivalent to typing: % hsi -h archive.nersc.gov HSI

  8. Data Management

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Data Management Data Management PDSF and IHEP, in Beijing, China, are the two main computing facitilies for the Daya Bay experiment with PDSF being used primarily by North American collaborators and IHEP by Asian collaborators. All raw data from the experimental facility is first transferred to IHEP and then transferred to PDSF. Data transfer rates of 5 to 10 MB/s result in up to about 500GB transferred daily. The tool used to transfer the data is called SPADE and has also been used at PDSF by

  9. Data Management

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Data Management Data Management Data Transfer STAR makes use of grid-based file transfers between PDSF and Brookhaven for two main purposes. The first is to transfer input/output files for simulation jobs submitted from Brookhaven to/from PDSF. The jobs come in through pdsfgrid.nersc.gov making use of the OSG software installation and the files are transferred through pdsfdtn1.nersc.gov to and from /project/projectdirs/osg. The second purpose is for bulk replication of microDST's from

  10. HSF1 and NF-κB p65 participate in the process of exercise preconditioning attenuating pressure overload-induced pathological cardiac hypertrophy

    SciTech Connect (OSTI)

    Xu, Tongyi; Zhang, Ben; Yang, Fan; Cai, Chengliang; Wang, Guokun; Han, Qingqi; Zou, Liangjian

    2015-05-08

    Pathological cardiac hypertrophy, often accompanied by hypertension, aortic stenosis and valvular defects, is typically associated with myocyte remodeling and cardiac dysfunction. Exercise preconditioning (EP) has been proven to enhance the tolerance of the myocardium to cardiac ischemia-reperfusion injury. However, the effects of EP in pathological cardiac hypertrophy are rarely reported. 10-wk-old male Sprague–Dawley rats (n = 80) were randomly divided into four groups: sham, TAC, EP + sham and EP + TAC. Two EP groups were subjected to 4 weeks of treadmill training, and the EP + TAC and TAC groups were followed by TAC operations. The sham and EP + sham groups underwent the same operation without aortic constriction. Eight weeks after the surgery, we evaluated the effects of EP by echocardiography, morphology, and histology and observed the expressions of the associated proteins. Compared with the respective control groups, hypertrophy-related indicators were significantly increased in the TAC and EP + TAC groups (p < 0.05). However, between the TAC and EP + TAC groups, all of these changes were effectively inhibited by EP treatment (p < 0.05). Furthermore, EP treatment upregulated the expression of HSF1 and HSP70, increased the HSF1 levels in the nuclear fraction, inhibited the expression of the NF-κB p65 subunit, decreased the NF-κB p65 subunit levels in the nuclear fraction, and reduced the IL2 levels in the myocardia of rats. EP could effectively reduce the cardiac hypertrophic responses induced by TAC and may play a protective role by upregulating the expressions of HSF1 and HSP70, activating HSF1 and then inhibiting the expression of NF-κB p65 and nuclear translocation. - Highlights: • EP could effectively reduce the cardiac hypertrophic responses induced by TAC. • EP may play a protective role by upregulating the expressions of HSF1 and HSP70 and then activating HSF1. • EP may play a protective role by inhibiting the expression

  11. Oracle Management Tool Suite

    Energy Science and Technology Software Center (OSTI)

    2007-06-01

    The Oracle Management Tool Suite is used to automatically manage Oracle based systems. This includes startup and shutdown of databases and application servers as well as backup, space management, workload management and log file management.

  12. NF_Eder_2013

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    ... and temperatures ranging from low-density hot plasmas to cold fragmenting solids. ... number and cost of optics 2 Nucl. Fusion 53 (2013) 113037 D.C. Eder et al and diagnostics. ...

  13. Managing Critical Management Improvement Initiatives

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2003-10-01

    Provides requirements and responsibilities for planning, executing and assessing critical management improvement initiatives within DOE. DOE N 251.59, dated 9/27/2004, extends this Notice until 10/01/2005. Archived 11-8-10. Does not cancel other directives.

  14. TGF-{beta}1 increases invasiveness of SW1990 cells through Rac1/ROS/NF-{kappa}B/IL-6/MMP-2

    SciTech Connect (OSTI)

    Binker, Marcelo G.; CBRHC Research Center, Buenos Aires ; Binker-Cosen, Andres A.; Gaisano, Herbert Y.; Cosen, Rodica H. de; Cosen-Binker, Laura I.

    2011-02-04

    Research highlights: {yields} Rac1 mediates TGF-{beta}1-induced SW1990 invasion through MMP-2 secretion and activation. {yields} NADPH-generated ROS act downstream of Rac1 in TGF-{beta}1-challenged SW1990 cells. {yields} TGF-{beta}1-stimulated ROS activate NF-{kappa}B in SW1990 cells. {yields} NF{kappa}B-induced IL-6 release is required for secretion and activation of MMP-2 in SW1990 cells. -- Abstract: Human pancreatic cancer invasion and metastasis have been found to correlate with increased levels of active matrix metalloproteinase 2 (MMP-2). The multifunctional cytokine transforming growth factor beta 1 (TGF-{beta}1) has been shown to increase both secretion of MMP-2 and invasion by several pancreatic cancer cell types. In the present study, we investigated the signaling pathway involved in TGF-{beta}1-promoted MMP-2 secretion and invasion by human pancreatic cancer cells SW1990. Using specific inhibitors, we found that stimulation of these tumor cells with TGF-{beta}1 induced secretion and activation of the collagenase MMP-2, which was required for TGF-{beta}1-stimulated invasion. Our results also indicate that signaling events involved in TGF-{beta}1-enhanced SW1990 invasiveness comprehend activation of Rac1 followed by generation of reactive oxygen species through nicotinamide adenine dinucleotide phosphate-oxidase, activation of nuclear factor-kappa beta, release of interleukin-6, and secretion and activation of MMP-2.

  15. Management Overview

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Fuel Disposition Campaign Sandia National Laboratories is a multi-mission laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000. SAND2016-11152 PE. Advanced Sensors and Instrumentation: Used Nuclear Fuel Program Storage and Transportation Overview Charles Bryan Sandia National Laboratories 2016 DOE NE Advanced Sensors and

  16. Environmental Management

    ScienceCinema (OSTI)

    None

    2016-07-12

    Another key aspect of the NNSS mission is Environmental Management program, which addresses the environmental legacy from historic nuclear weapons related activities while also ensuring the health and safety of present day workers, the public, and the environment as current and future missions are completed. The Area 5 Radioactive Waste Management site receives low-level and mixed low-level waste from some 28 different generators from across the DOE complex in support of the legacy clean-up DOE Environmental Management project. Without this capability, the DOE would not be able to complete the clean up and proper disposition of these wastes. The program includes environmental protection, compliance, and monitoring of the air, water, plants, animals, and cultural resources at the NNSS. Investigation and implementation of appropriate corrective actions to address the contaminated ground water facilities and soils resulting from historic nuclear testing activities, the demolition of abandoned nuclear facilities, as well as installation of ground water wells to identify and monitor the extent of ground water contamination.

  17. Environmental Management

    SciTech Connect (OSTI)

    2014-11-12

    Another key aspect of the NNSS mission is Environmental Management program, which addresses the environmental legacy from historic nuclear weapons related activities while also ensuring the health and safety of present day workers, the public, and the environment as current and future missions are completed. The Area 5 Radioactive Waste Management site receives low-level and mixed low-level waste from some 28 different generators from across the DOE complex in support of the legacy clean-up DOE Environmental Management project. Without this capability, the DOE would not be able to complete the clean up and proper disposition of these wastes. The program includes environmental protection, compliance, and monitoring of the air, water, plants, animals, and cultural resources at the NNSS. Investigation and implementation of appropriate corrective actions to address the contaminated ground water facilities and soils resulting from historic nuclear testing activities, the demolition of abandoned nuclear facilities, as well as installation of ground water wells to identify and monitor the extent of ground water contamination.

  18. ORISE: Emergency Management

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Management Emergency Management Effective emergency management relies on thorough integration of preparedness plans at all levels of government. The Oak Ridge Institute for Science...

  19. Environmental Management System

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Management System Environmental Management System An Environmental Management System (EMS) is a set of processes and practices that enable an organization to reduce its...

  20. M E Environmental Management Environmental Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    safety  performance  cleanup  closure M E Environmental Management Environmental Management safety  performance  cleanup  closure M E Environmental Management Environmental Management M E Environmental Management Environmental Management Office of Site Restoration, EM-10 Office of D&D and Facility Engineering, EM-13 Facility Deactivation & Decommissioning (D&D) D&D Program Map Addendum: Impact of American Recovery and Reinvestment Act (ARRA) on EM's D&D

  1. Best Management Practice #1: Water Management Planning

    Office of Energy Efficiency and Renewable Energy (EERE)

    A successful water management program starts with developing a comprehensive water management plan. This plan should be included within existing facility operating plans.

  2. Chemical Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    DOE-HDBK-1139/1-2006 May 2006 DOE HANDBOOK CHEMICAL MANAGEMENT (Volume 1 of 3) U.S. Department of Energy AREA SAFT Washington, D.C. 20585 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. NOT MEASUREMENT SENSITIVE This document has been reproduced from the best available copy. Available to DOE and DOE contractors from ES&H Technical Information Services, U.S. Department of Energy, (800) 473-4375, fax: (301) 903-9823. Available to the public from the U.S.

  3. 2016 DOE Project Management Workshop - "Enhancing Project Management...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    6 DOE Project Management Workshop - "Enhancing Project Management" 2016 DOE Project Management Workshop - "Enhancing Project Management" 20160407-doe-project-management-workshop-AD...

  4. Risk Management Process Overview

    Energy.gov [DOE]

    The cybersecurity risk management process explained in the Electricity Sector Cybersecurity Risk Management Process (RMP) Guideline has two primary components: the risk management model and the the risk management cycle.

  5. Cyanidin-3-glucoside inhibits UVB-induced oxidative damage and inflammation by regulating MAP kinase and NF-κB signaling pathways in SKH-1 hairless mice skin

    SciTech Connect (OSTI)

    Pratheeshkumar, Poyil; Son, Young-Ok; Wang, Xin; Divya, Sasidharan Padmaja; Joseph, Binoy; Hitron, John Andrew; Wang, Lei; Kim, Donghern; Yin, Yuanqin; Roy, Ram Vinod; Lu, Jian; Zhang, Zhuo; Wang, Yitao; and others

    2014-10-01

    Skin cancer is one of the most commonly diagnosed cancers in the United States. Exposure to ultraviolet-B (UVB) radiation induces inflammation and photocarcinogenesis in mammalian skin. Cyanidin-3-glucoside (C3G), a member of the anthocyanin family, is present in various vegetables and fruits especially in edible berries, and displays potent antioxidant and anticarcinogenic properties. In this study, we have assessed the in vivo effects of C3G on UVB irradiation induced chronic inflammatory responses in SKH-1 hairless mice, a well-established model for UVB-induced skin carcinogenesis. Here, we show that C3G inhibited UVB-induced skin damage and inflammation in SKH-1 hairless mice. Our results indicate that C3G inhibited glutathione depletion, lipid peroxidation and myeloperoxidation in mouse skin by chronic UVB exposure. C3G significantly decreased the production of UVB-induced pro-inflammatory cytokines, such as IL-6 and TNF-α, associated with cutaneous inflammation. Likewise, UVB-induced inflammatory responses were diminished by C3G as observed by a remarkable reduction in the levels of phosphorylated MAP kinases, Erk1/2, p38, JNK1/2 and MKK4. Furthermore, C3G also decreased UVB-induced cyclooxygenase-2 (COX-2), PGE{sub 2} and iNOS levels, which are well-known key mediators of inflammation and cancer. Treatment with C3G inhibited UVB-induced nuclear translocation of NF-κB and degradation of IκBα in mice skin. Immunofluorescence assay revealed that topical application of C3G inhibited the expression of 8-hydroxy-2′-deoxyguanosine, proliferating cell nuclear antigen, and cyclin D1 in chronic UVB exposed mouse skin. Collectively, these data indicates that C3G can provide substantial protection against the adverse effects of UVB radiation by modulating UVB-induced MAP kinase and NF-κB signaling pathways. - Highlights: • C3G inhibited UVB-induced oxidative damage and inflammation. • C3G inhibited UVB-induced COX-2, iNOS and PGE{sub 2} production. • C3G

  6. Integrated Safety Management Policy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    INTEGRATED SAFETY MANAGEMENT SYSTEM DESCRIPTION U.S. DEPARTMENT OF ENERGY Office of Environmental Management Headquarters May 2008 Preparation: Braj K. sin& Occupational Safety and Health Manager Office of Safety Management Concurrence: Chuan-Fu wu Director, Offlce of Safety Management Deputy Assistant Secretary for safe& Management andoperations Operations Officer for 1 Environmental Management Approval: Date p/-g Date Environmental Management TABLE OF CONTENTS

  7. Energy Management and Financing

    Office of Energy Efficiency and Renewable Energy (EERE)

    This Tuesday Webcast for Industry covers how to become a Certified Energy Manager and Certified Practitioner in Energy Management Systems

  8. ENVIRONMENTAL MANAGEMENT ADVISORY BOARD

    Office of Environmental Management (EM)

    ... Assistant Secretary for Safety and Management Operations ... Management Advisory Board EM SSAB - Environmental ... ETR - External Technical Review ETTP - East Tennessee ...

  9. Estimated (n,f) cross sections for 236,236m237,238-Np, 237,237m-Pu, and 240,241,242,242m,243,244,244m-Am isotopes

    SciTech Connect (OSTI)

    Younes, W; Becker, J; Britt, H

    2004-01-16

    Neutron-induced fission cross sections on targets of {sup 236,236m,237,238}Np, {sup 237,237m}Pu, and {sup 240,241,242,242m,243,244,244m}Am have been estimated for incident neutron energies of up to 6 MeV, using the ''surrogate'' technique and the ({sup 3}He,df) and ({sup 3}He,tf) reactions on stable targets to measure fission probabilities. In isotopes where low-lying isomeric states are known to exist, the (n,f) cross section on the corresponding isomeric targets has been estimated, using the surrogate technique. For targets of {sup 237}Np, {sup 241}Am, {sup 242m}Am, {sup 243}Am, measurements of the (n,f) cross section exist, and comparison with the surrogate-method results suggests that the (n,f) cross sections estimated by the surrogate technique are reliable to within 10% for incident neutron energies E{sub n}{approx}>2 MeV. Tabulated values of the estimated (n,f) cross sections are given in an appendix.

  10. Integrated Safety Management and Environmental Management

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Laboratory | Department of Energy Integrated Safety Management Workshop Registration, PIA, Idaho National Laboratory Integrated Safety Management Workshop Registration, PIA, Idaho National Laboratory Integrated Safety Management Workshop Registration, PIA, Idaho National Laboratory Integrated Safety Management Workshop Registration, PIA, Idaho National Laboratory (265.91 KB) More Documents & Publications TRAIN-PIA.pdf Occupational Medicine - Assistant PIA, Idaho National Laboratory PIA -

  11. John Angelis named Manager, Information Resource Management

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Names John S. Angelis Manager of Information Resource Management CARLSBAD, N.M., March 22, 2000 - The Westinghouse Waste Isolation Division (WID) has named John S. Angelis of Carlsbad as Manager of Information Resource Management at the Waste Isolation Pilot Plant (WIPP). "John's extensive computer technology and telecommunications experience, combined with his progressive attitude, make him an ideal choice for this increasingly important position," said WID General Manager Joe

  12. miR-15a/16 Enhances Radiation Sensitivity of Non-Small Cell Lung Cancer Cells by Targeting the TLR1/NF-κB Signaling Pathway

    SciTech Connect (OSTI)

    Lan, Fengming; Yue, Xiao; Ren, Gang; Li, Hongqi; Ping, Li; Wang, Yingjie; Xia, Tingyi

    2015-01-01

    Purpose: Many miRNAs have been identified as essential issues and core determining factors in tumor radiation. Recent reports have demonstrated that miRNAs and Toll-like receptors could exert reciprocal effects to control cancer development in various ways. However, a novel role of miR-15a/16 in enhancing radiation sensitivity by directly targeting TLR1 has not been reported, to our knowledge. Methods and Materials: Bioinformatic analyses, luciferase reporter assay, biochemical assays, and subcutaneous tumor establishment were used to characterize the signaling pathways of miRNA-15a/16 in response to radiation treatment. Results: First, an inverse correlation between the expression of miR-15a/16 and TLR1 protein was revealed in non-small cell lung cancer (NSCLC) and normal lung tissues. Next, we corroborated that miR-15a/16 specifically bound to TLR1 3′UTR and inhibited the expression of TLR1 in H358 and A549 cells. Furthermore, miR-15a/16 downregulated the activity of the NF-κB signaling pathway through TLR1. In addition, overexpression of miR-15a/16 inhibited survival capability and increased radiation-induced apoptosis, resulting in enhancement of radiosensitivity in H358 and A549 cells. Finally, subcutaneous tumor bearing NSCLC cells in a nude mice model was established, and the results showed that combined groups (miR-15a/16 + radiation) inhibited tumor growth more significantly than did radiation alone. Conclusions: We mainly elucidate that miRNA-15a/16 can enhance radiation sensitivity by regulating the TLR1/NF-κB signaling pathway and act as a potential therapeutic approach to overcome radioresistance for lung cancer treatment.

  13. DOE Jobs Online (Hiring Manager), Office of Human Capitol Management...

    Energy.gov (indexed) [DOE]

    Jobs Online (Hiring Manager), Office of Human Capitol Management Innovation and Solutions DOE Jobs Online (Hiring Manager), Office of Human Capitol Management Innovation and ...

  14. AWWA Utility Management Conference

    Energy.gov [DOE]

    Hosted by the American Water Works Association (AWWA), the Utility Management Conference is one of the leading management conferences to share experiences and learn from others in similar situations to the most pressing management issues of the day.

  15. Managing Your User Account

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Managing Your Account Managing Your User Account Use the NERSC Information Management (NIM) system to customize your user account and keep your personal information up-to-date. See...

  16. BETO Active Project Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    BETO Active Project Management Bioenergy Technologies Office - Program Management Review 6/25/15 Liz Moore Technology Manager eere.energy.gov Program Managers * Manages portfolio within their technology area * Establishes technical and cost goals * Strategic planning for technology area * Budget preparation/justification for technology portfolio * Identifies needs for workshops and FOAs * Oversees portfolio reviews including high-level project status Technology Managers * Plans/conducts

  17. Data Management Policy The

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Management Policy The guidelines below describe Data Management procedures, processes and resources that need to be understood by both user projects and in-house research. 1....

  18. Land Management - Hanford Site

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Land Management About Us About Hanford Cleanup Hanford History Hanford Site Wide Programs Contact Us Land Management Email Email Page | Print Print Page |Text Increase Font Size...

  19. Technical Standards Managers

    Energy.gov (indexed) [DOE]

    FACILITYADDRESS LOC CODE DOE TECHNICAL STANDARD MANAGERS AU-30 DOE Technical Standards ... FACILITYADDRESS LOC CODE DOE TECHNICAL STANDARD MANAGERS DOE-CTA TSM Gustave E. (Bud) ...

  20. Defense Waste Management Programs

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Nuclear Energy Defense Waste Management Programs Advanced Nuclear Energy Nuclear Energy ... Twitter Google + Vimeo Newsletter Signup SlideShare Defense Waste Management Programs ...

  1. Supply Management Specialist

    Energy.gov [DOE]

    This position is located in the Logistics Management organization (NSL), Supply Chain Services (NS), Chief Administrative Office (N). NSL manages the warehousing of materials; the investment...

  2. COMPREHENSIVE LEGACY MANAGEMENT

    Office of Legacy Management (LM)

    Fernald Preserve, Fernald, Ohio Comprehensive Legacy Management and Institutional Controls ... blank LMSFERS03496-8.0 Comprehensive Legacy Management and Institutional Controls ...

  3. Contract/Project Management

    Energy.gov (indexed) [DOE]

    Third Quarter Overall Contract and Project Management Performance Metrics and Targets 1 ContractProject Management Primary Performance Metrics FY 2010 Target FY 2010 Forecast FY ...

  4. Contract/Project Management

    Energy.gov (indexed) [DOE]

    Contract and Project Management Performance Metrics and Targets 1 ContractProject Management Primary Performance Metrics FY 2011 Target FY 2011 Actual & Forecast FY 2011 Pre- & ...

  5. Contract/Project Management

    Energy.gov (indexed) [DOE]

    and Project Management Improvement Performance Metrics and Targets 1 ContractProject Management Primary Performance Metrics FY 2011 Target FY 2011 Forecast FY 2011 Pre- & ...

  6. Contract/Project Management

    Energy.gov (indexed) [DOE]

    Second Quarter Overall Contract and Project Management Improvement Performance Metrics and Targets 1 ContractProject Management Performance Metric FY 2012 Target FY 2012 Forecast ...

  7. Contract/Project Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Fourth Quarter Overall Contract and Project Management Improvement Performance Metrics and Targets 1 ContractProject Management Primary Performance Metrics FY 2011 Target FY 2011 ...

  8. Contract/Project Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    2 nd Quarter Overall Contract and Project Management Performance Metrics and Targets ContractProject Management Performance Metrics FY 2009 Target FY 2009 Actual Comment 1. ...

  9. Contract/Project Management

    Energy.gov (indexed) [DOE]

    3 First Quarter Overall Contract and Project Management Improvement Performance Metrics and Targets 1 ContractProject Management Performance Metric FY 2013 Target FY 2013 Final FY ...

  10. Contract/Project Management

    Energy.gov (indexed) [DOE]

    3 rd Quarter Overall Contract and Project Management Performance Metrics and Targets ContractProject Management Performance Metrics FY 2009 Target FY 2009 Actual Comment 1. ...

  11. Contract/Project Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Fourth Quarter Overall Contract and Project Management Performance Metrics and Targets 1 ContractProject Management Primary Performance Metrics FY 2010 Target FY 2010 Actual FY ...

  12. Contract/Project Management

    Energy.gov (indexed) [DOE]

    Third Quarter Overall Contract and Project Management Improvement Performance Metrics and Targets 1 ContractProject Management Performance Metric FY 2012 Target FY 2012 Forecast ...

  13. Contract/Project Management

    Energy.gov (indexed) [DOE]

    Action Plan (CAP) Performance Metrics 1 ContractProject Management Performance Metric FY ... TPC is Total Project Cost. ContractProject Management Performance Metrics FY 2013 Target ...

  14. Contract/Project Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Action Plan (CAP) Performance Metrics 1 ContractProject Management Performance Metric FY ... to FY13). TPC is Total Project Cost. ContractProject Management Performance Metrics ...

  15. Contract/Project Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Fourth Quarter Overall Contract and Project Management Improvement Performance Metrics and Targets 1 ContractProject Management Performance Metric FY 2012 Target FY 2012 Final FY ...

  16. Contract/Project Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Third Quarter Overall Contract and Project Management Improvement Performance Metrics and Targets 1 ContractProject Management Primary Performance Metrics FY 2011 Target FY 2011 ...

  17. Contract/Project Management

    Energy.gov (indexed) [DOE]

    Second Quarter Overall Contract and Project Management Performance Metrics and Targets 1 ContractProject Management Primary Performance Metrics FY 2010 Target FY 2010 Actual FY ...

  18. Contract/Project Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    1 st Quarter Overall Contract and Project Management Performance Metrics and Targets ContractProject Management Performance Metrics FY 2009 Target FY 2009 Actual Comment 1. ...

  19. Contract/Project Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    4 th Quarter Metrics Final Overall Contract and Project Management Performance Metrics and Targets ContractProject Management Performance Metrics FY 2009 Target FY 2009 Actual ...

  20. Contract/Project Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    8 4 th Quarter Metrics Final Overall Contract and Project Management Performance Metrics and Targets ContractProject Management Performance Metrics FY 2008 Target FY 2008 Actual ...

  1. End Points Management

    Energy.gov [DOE]

    The policy of the EM is that a formal project management approach be used for the planning, managing, and conducting of its projects.

  2. Management of Nuclear Materials

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2009-08-17

    To establish requirements for the lifecycle management of DOE owned and/or managed accountable nuclear materials. Cancels DOE O 5660.1B.

  3. Ross Management | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Management Jump to: navigation, search Name: Ross Management Place: Goldendale, Washington State Product: Ross Management is the management parent for a group of family owned...

  4. Environmental Management System

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Management System Environmental Management System An Environmental Management System is a systematic method for assessing mission activities, determining the environmental impacts of those activities, prioritizing improvements, and measuring results. May 30, 2012 The continuous improvement cycle Our Environmental Management System encourages continuous improvement of our environmental performance. Contact Environmental Communication & Public Involvement P.O. Box 1663 MS M996 Los Alamos, NM

  5. Chemical Management Contacts

    Energy.gov [DOE]

    Contacts for additional information on Chemical Management and brief description on Energy Facility Contractors Group

  6. The (3He,tf) as a surrogate reaction to determine (n,f) cross sections in the 10 to 20 MeV energy range

    SciTech Connect (OSTI)

    Basunia, M. S.; Clark, R. M.; Goldblum, B. L.; Bernstein, L. A.; Phair, L.; Burke, J. T.; Beausang, C. W.; Bleuel, D. L.; Darakchieva, B.; Dietrich, F. S.; Evtimova, M.; Fallon, P.; Gibelin, J.; Hatarik, R.; Jewett, C. C.; Lesher, S. R.; McMahan, M. A.; Rodriguez-Vieitez, E.; Wiedeking, M.

    2009-02-25

    The surrogate reaction 238U(3He,tf) is used to determine the 237Np(n,f) cross section indirectly over an equivalent neutron energy range from 10 to 20 MeV. A self-supporting ~;;761 mu g/cm2 metallic 238U foil was bombarded with a 42 MeV 3He2+ beam from the 88-Inch Cyclotron at Lawrence Berkeley National Laboratory (LBNL). Outgoing charged particles and fission fragments were identified using the Silicon Telescope Array for Reaction Studies (STARS), consists of two 140 mu m and one 1000 mu m Micron S2 type silicon detectors. The 237Np(n,f) cross sections, determined indirectly, were compared with the 237Np(n,f) cross section data from direct measurements, the Evaluated Nuclear Data File (ENDF/B-VII.0), and the Japanese Evaluated Nuclear Data Library (JENDL 3.3) and found to closely follow those datasets. Use of the (3He,tf) reaction as a surrogate to extract (n,f) cross section in the 10 to 20 MeV equivalent neutron energy is found to be suitable.

  7. Manager`s views of public involvement

    SciTech Connect (OSTI)

    Branch, K.M.; Heerwagen, J.; Bradbury, J.

    1995-12-01

    Four issues commonly form the framework for debates about the acceptability of proposed projects or technologies--the substantive decision or technological choice; the treatment of the community by the proponent organization; the way the decision-making process has been structured and managed; and the status of institutional safeguards and protection. One of the clear messages of cultural theory is that differences in perspectives are a normal and inevitable part of society, and that attempts to resolve differences by persuasion are not likely to work. These findings are useful when considering the goals and possibilities of public involvement as a decision-making tool, and when designing or evaluating public involvement training programs for managers. The research reported here examines the viewpoints and concerns of managers and decision-makers about the four issues identified above, with particular emphasis on their perspectives and concerns about opening decision-making processes to the public and about managers` roles and responsibilities for structuring and managing open decision-making processes. Implications of these findings for public involvement training for managers is also discussed. The data presented in this paper were obtained from face-to-face interviews with managers and decision-makers with experience managing a variety of hazardous waste management decision-making processes. We conducted these interviews in the course of four separate research projects: needs assessments to support the design and development of a public involvement training program for managers; a study of community residents` and managers` perspectives on the chemical stockpile disposal program; an evaluation of the effectiveness of public involvement training for managers in the Department of Energy; and a study to develop indicators of the benefits and costs of public involvement.

  8. 2014 DOE Project Management Workshop

    Energy.gov [DOE]

    What:  2014 DOE Project Management Workshop (Meeting the Challenge—Integrated Acquisition & Project Management)

  9. Project Manager's Guide to Managing Impact and Process Evaluation...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Project Manager's Guide to Managing Impact and Process Evaluation Studies This report provides a step-by-step approach to help managers of EERE evaluation projects create and ...

  10. Manager's Desk Reference on Human Capital Management Flexibilities...

    Energy.gov (indexed) [DOE]

    that can be used in day-to-day human capital management activities, especially ... Manager's Desk Reference on Human Capital Management Flexibilities (640.69 KB) Responsible ...

  11. Loan Specialist (Risk Management)

    Energy.gov [DOE]

    This position is located in the U.S. Department of Energy (DOE), Loan Programs Office (LPO), Risk Management Division (RMD), and Enterprise Risk Management & Compliance Branch. The LPO mission...

  12. Improving Project Management

    Office of Energy Efficiency and Renewable Energy (EERE)

    On December 19, 2014, the Energy Department released its "Improving Project Management" report, a roadmap to transformation in funding, culture, project ownership, independent oversight and front-end planning from experienced project management leaders.

  13. Information Technology Project Management

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2012-12-03

    The Order provides program and project management direction for the acquisition and management of IT projects, investments, and initiatives. Cancels DOE G 200.1-1. Admin Chg 1 approved 1-16-2013.

  14. Information Technology Project Management

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2012-12-03

    The Order provides program and project management direction for the acquisition and management of IT projects, investments, and initiatives. Admin Chg 1, dated 1-16-2013, supersedes DOE O 415.1.

  15. Risk Management Guide

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2011-01-18

    This Guide provides non-mandatory risk management approaches for implementing the requirements of DOE O 413.3B, Program and Project Management for the Acquisition of Capital Assets. Supersedes DOE G 413.3-7.

  16. Stage Gate Management Guide

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Stage Gate Management in the Biomass Program February 2005 Revision 2 2 TABLE OF CONTENTS OVERVIEW............................................................................................................................. 4 STAGE GATE MANAGEMENT .................................................................................................... 4 STAGE GATE PROCESS AND LONG RANGE STRATEGIC PROGRAM PLANNING ........................ 5 GATE REVIEWS

  17. Risk Management Guide

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2011-01-12

    The purpose of this guide is to describe effective risk management processes. The continuous and iterative process includes updating project risk documents and the risk management plan and emphasizes implementation communication of the risks and actions taken.

  18. Management of Nuclear Materials

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2009-08-17

    To establish requirements for the lifecycle management of DOE owned and/or managed accountable nuclear materials. Admin Chg 1 dated 4-10-2014, supersedes DOE O 410.2.

  19. Management Associate I

    Energy.gov [DOE]

    A successful candidate in this position will serve as an analyst and advisor to an organization's manager and other managers within the organization within BPA. The position serves as a point of...

  20. Contract/Project Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    1 st Quarter Overall Contract and Project Management Performance Metrics and Targets 1 ContractProject Management Primary Performance Metrics FY 2010 Target 1st Qtr FY 2010 Actual ...

  1. emergency management systems

    National Nuclear Security Administration (NNSA)

    9%2A en Building International Emergency Management Systems http:nnsa.energy.govaboutusourprogramsemergencyoperationscounterterrorisminternationalprograms-1

  2. System Management Software

    Energy Science and Technology Software Center (OSTI)

    2013-02-22

    MacPatch is Mac OS X system management software solution. It's used for patching, software distribution and inventory.

  3. NERSC Data Management Policies

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Data Management Policies NERSC Data Management Policies Introduction NERSC provides its users with the means to store, manage, and share their research data products. In addition to systems specifically tailored for data-intensive computations, we provide a variety of storage resources optimized for different phases of the data lifecycle; tools to enable users to manage, protect, and control their data; high-speed networks for intra-site and inter-site (ESnet) data transfer; gateways and portals

  4. ARM - Metadata Management Tool

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    FormsMetadata Management Tool Ingest Ingest Workflow Graphic Supporting Workflow Documentation Supporting Tools and Forms Process Configuration Manager (PCM) Metadata Management Tool (MMT) ARM Data Integrator (ADI) Ingest Readiness Form Associated Status Reports Contacts Engineering Processes Engineering Home Workflow Graphic Engineering Workflow Document Tools for Workflow ECR ECO BCR Ingests Value-Added Products Reprocessing Instruments Data System Elements Field Campaign Startup Metadata

  5. ARM - Process Configuration Manager

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    FormsProcess Configuration Manager Ingest Ingest Workflow Graphic Supporting Workflow Documentation Supporting Tools and Forms Process Configuration Manager (PCM) Metadata Management Tool (MMT) ARM Data Integrator (ADI) Ingest Readiness Form Associated Status Reports Contacts Engineering Processes Engineering Home Workflow Graphic Engineering Workflow Document Tools for Workflow ECR ECO BCR Ingests Value-Added Products Reprocessing Instruments Data System Elements Field Campaign Startup Process

  6. Energy, Data Management, Reporting

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Design the Strategy | Deliver Efficiency | Sustain Results Energy, Data Management, Reporting This presentation does not contain any proprietary, confidential, or otherwise restricted information. - - Agenda ● About Schneider Electric ● Enterprise wide Data Management ● Outputs ● Foundation and results ● Part of a complete energy management solution Schneider Electric Sustainability Services 2014 2 - - Schneider Electric Sustainability Services 2014 3 Schneider Electric - the global

  7. Energy Manager Webinar Series

    Energy.gov [DOE]

    Energy Managers from leading manufacturing companies share lessons learned from implementing energy savings projects in these one-hour webinars. Topics include real-world challenges like creating a climate for successful project implementation, gaining management support, and obtaining financing. Each webinar highlights a different topic and features an energy manager from a different Better Plants Partner.

  8. Financial Management Oversight

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2006-08-31

    The Order defines requirements for effective financial management and adherence to DOE and applicable external financial management requirements and sets forth standards for ensuring the integrity and responsiveness of financial management and the accuracy and reliability of DOEs financial statements. Supersedes DOE O 2200.13.

  9. Executive Branch Management Scorecard | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Branch Management Scorecard Executive Branch Management Scorecard PDF icon Executive Branch Management Scorecard More Documents & Publications Executive Branch Management Scorecard ...

  10. Environmental Management Advisory Board (EMAB) | Department of...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Environmental Management Advisory Board (EMAB) Environmental Management Advisory Board (EMAB) Environmental Management Advisory Board (EMAB) Environmental Management Advisory Board ...

  11. Program Management | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Management Program Management Safety Safety The Office of Environmental Management's (EM) top priority is to ensure proper implementation and continuous improvement of Integrated ...

  12. ENVIRONMENTAL MANAGEMENT OFFICE OF ENVIRONMENTAL MANAGEMENT

    Office of Environmental Management (EM)

    ... 290 1,483 Moab 245 320 *Mound 0 54 Nevada National Security Site 63 748 Oak Ridge ... Demonstration Project 77 408 Title X UraniumThorium Reimbursements 9 9 Management & ...

  13. Managing a Process Safety Management inspection

    SciTech Connect (OSTI)

    Mulvey, N.P. [AcuTech Consulting, Inc., Princeton, NJ (United States)

    1995-12-31

    The Occupational Safety and Health Administration (OSHA) Process Safety Management (PSM) regulations (29 CFR {section} 1910.119) have been in effect for almost three years. State level risk management programs, in New Jersey, California, and Delaware have been in effect for over six years. More recently, Nevada and Louisiana have enacted process safety management programs. These regulations have had a significant impact on all phases of plant operations, including preliminary design, construction, startup, and operations. Through proper planning and the commitment of resources, many facilities are beginning to realize the benefits of well developed PSM programs. This paper will discuss in greater detail some of these benefits, and in particular, the subject of governmental inspections of facilities for process safety management programs.

  14. Radioactive Waste Management Basis

    SciTech Connect (OSTI)

    Perkins, B K

    2009-06-03

    The purpose of this Radioactive Waste Management Basis is to describe the systematic approach for planning, executing, and evaluating the management of radioactive waste at LLNL. The implementation of this document will ensure that waste management activities at LLNL are conducted in compliance with the requirements of DOE Order 435.1, Radioactive Waste Management, and the Implementation Guide for DOE Manual 435.1-1, Radioactive Waste Management Manual. Technical justification is provided where methods for meeting the requirements of DOE Order 435.1 deviate from the DOE Manual 435.1-1 and Implementation Guide.

  15. Multimedia environmental management

    SciTech Connect (OSTI)

    Soesilo, J.A.; Wiley, W.D.

    1999-09-01

    This book explores and supports the argument that effective environmental management must be based on a multimedia approach, which focuses simultaneously on air, water, and waste and enables managers to assess the resulting financial, operation, and management benefits. The multimedia approach, which can be used to design an effective compliance program, includes proper waste and material handling management, systematic monitoring, and record keeping requirements. This approach integrates a wide array of environmental requirements and decision processes, which the authors examine in sixteen chapters, organized into four parts: the role of environmental management; environmental aspects of business operation, environmental processes; and environmental management trends. Within these parts, the authors highlight the development of modern environmental management and provide an overview of federal laws pertinent to multimedia environmental management. They examine such issues as chemical storage and transportation, tank system operations and requirements, waste determination, spill response procedures, and employee training. Environmental processes addressed in the book include the management of solid and hazardous waste, wastewater treatment systems, stormwater management, air emission control, and site remediation. The authors also briefly discuss significant initiatives in US environmental management and look toward corporate sustainable development.

  16. DOE Office of Environmental Management Project and Contract Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Improvement Timeline | Department of Energy Acquisition » DOE Office of Environmental Management Project and Contract Management Improvement Timeline DOE Office of Environmental Management Project and Contract Management Improvement Timeline Improving DOE contract and project management is a top priority of the Department's senior management and entire organization. View some highlights of EM's improvement actions here. DOE Office of Environmental Management Contract and Project Management

  17. DOE - Office of Legacy Management -- Fernald Environmental Management...

    Office of Legacy Management (LM)

    Fernald Environmental Management Project - 027 FUSRAP Considered Sites Site: Fernald Environmental Management Project (027) Designated Name: Alternate Name: Location: Evaluation ...

  18. DOE Jobs Online (Hiring Manager), Office of Human Capitol Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Innovation and Solutions | Department of Energy Jobs Online (Hiring Manager), Office of Human Capitol Management Innovation and Solutions DOE Jobs Online (Hiring Manager), Office of Human Capitol Management Innovation and Solutions DOE Jobs Online (Hiring Manager), Office of Human Capitol Management Innovation and Solutions DOE Jobs Online (Hiring Manager), Office of Human Capitol Management Innovation and Solutions (1.46 MB) More Documents & Publications PIA - GovTrip (DOE data) LM

  19. ORO Names New Assistant Manager for Environmental Management

    Energy.gov [DOE]

    The U.S. Department of Energy Oak Ridge Office names John Eschenberg as its Assistant Manager for Environmental Management.

  20. Dietary turmeric modulates DMBA-induced p21{sup ras}, MAP kinases and AP-1/NF-{kappa}B pathway to alter cellular responses during hamster buccal pouch carcinogenesis

    SciTech Connect (OSTI)

    Garg, Rachana; Ingle, Arvind; Maru, Girish

    2008-11-01

    The chemopreventive efficacy of turmeric has been established in experimental systems. However, its mechanism(s) of action are not fully elucidated in vivo. The present study investigates the mechanism of turmeric-mediated chemoprevention in 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis at 2, 4, 6, 10 and 12 weeks. Dietary turmeric (1%) led to decrease in DMBA-induced tumor burden and multiplicity, and enhanced the latency period in parallel, to its modulatory effects on oncogene products and various cellular responses during HBP tumorigenesis. DMBA-induced expression of ras oncogene product, p21 and downstream target, the mitogen-activated protein kinases were significantly decreased by turmeric during HBP carcinogenesis. Turmeric also diminished the DMBA-induced mRNA expression of proto-oncogenes (c-jun, c-fos) and NF-{kappa}B, leading to decreased protein levels and in further attenuation of DMBA-induced AP-1/NF-{kappa}B DNA-binding in the buccal pouch nuclear extracts. Besides, buccal pouch of hamsters receiving turmeric diet showed significant alterations in DMBA-induced effects: (a) decrease in cell proliferation (diminished PCNA and Bcl2 expression), (b) enhanced apoptosis (increased expression of Bax, caspase-3 and apoptotic index), (c) decrease in inflammation (levels of Cox-2, the downstream target of AP-1/NF-{kappa}B, and PGE2) and (d) aberrant expression of differentiation markers, the cytokeratins (1, 5, 8, and 18). Together, the protective effects of dietary turmeric converge on augmenting apoptosis of the initiated cells and decreasing cell proliferation in DMBA-treated animals, which in turn, is reflected in decreased tumor burden, multiplicity and enhanced latency period. Some of these biomarkers are likely to be helpful in monitoring clinical trials and evaluating drug effect measurements.

  1. ADMINISTRATIVE SUPPORT INFORMATION MANAGEMENT ADMINISTRATIVE...

    National Nuclear Security Administration (NNSA)

    ... DIRECTOR, BUSINESS MANAGEMENT R&D S&E, ELECTRICAL ENGINEERING DIRECTOR, COMMUNICATIONS ... CONSTRUCTION MANAGER CHEMISTRY ELECTRICAL ENGINEER CRYPTOGRAPHY FACILITIES ...

  2. Strategies for Successful Energy Management

    Energy.gov [DOE]

    This presentation, given through the DOE's Technical Assitance Program (TAP), provides information on energy management for the portfolio manager initiative

  3. NREL Announces Management Changes

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Announces Management Changes For more information contact: Bob Noun (303) 275-3062 Golden, Colo., June 27, 1997 National Renewable Energy Laboratory (NREL) Director Richard Truly announced a reorganization that creates two new management positions at the laboratory. Effective July 1, 1997, Dr. Stanley Bull becomes Associate Director for Research Operations. He will manage the research and development of more than 30 renewable energy technologies such as solar energy, wind energy, fuels

  4. Senior Management - JCAP

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Senior Management Who We Are JCAP Mission JCAP At A Glance Fact Sheets Organizational Chart Recent Science Technology Transfer Awards & Honors Senior Management Scientific Leadership Researchers Governance & Advisory Boards Operations & Administration Who we are Overview JCAP Mission JCAP At A Glance Fact Sheets Organizational Chart Our Achievements Recent Science Technology Transfer Awards & Honors Our People Senior Management Scientific Leadership Researchers Governance &

  5. Configuration Management Program

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2003-10-27

    The purpose of this standard is to define the objectives of a configuration management process for DOE nuclear facilities (including activities and operations), and to provide detailed examples and supplementary guidance on methods of achieving those objectives. Configuration management is a disciplined process that involves both management and technical direction to establish and document the design requirements nd the physical configuration of the nuclear facility and to ensure that they remain consistent with each other and the documentation.

  6. Office of Personnel Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Personnel Management October 2014 Questions & Answers 1 Pathways Programs 5 CFR Parts 213, 302, 315, and 362 Questions and Answers Background Executive Order 13562 Recruiting and Hiring Students and Recent Graduates dated December 27, 2010, authorized two new excepted service hiring authorities and consolidated them with a revised Presidential Management Fellows Program to establish the Pathways Programs for students and recent graduates. The U.S. Office of Personnel Management (OPM)

  7. The REMOTE SENSlNf

    Office of Legacy Management (LM)

    ... Louis, MO Remedial Action Projects Ashland Oil, Tonawanda, NY (sites I and II) Seaway ... Gamma Ray Spectrometry. HASL-258. (United States Atomic Energy CornmIssIon, Health and ...

  8. Environmental Management System

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    of those activities, prioritizing improvements, and measuring results. May 30, 2012 The continuous improvement cycle Our Environmental Management System encourages continuous...

  9. E M Environmental Management

    Office of Environmental Management (EM)

    E M Environmental Management safety performance cleanup closure EM RECOVERY ACT TOP LINE MESSAGES * The Department estimates the 6 billion Recovery Act investment has allowed us ...

  10. Logistics Management Specialist

    Energy.gov [DOE]

    The Deputy Assistant Secretary for the Office of Petroleum Reserves (OPR) manages the Strategic Petroleum Reserve (SPR) and is responsible for establishing policies, goals, and priorities for the...

  11. Managing Increased Charging Demand

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Managing Increased Charging Demand Carrie Giles ICF International, Supporting the Workplace Charging Challenge Workplace Charging Challenge Do you already own an EV? Are you...

  12. Your Records Management Responsibilities

    Office of Environmental Management (EM)

    CYCLE ELECTRONIC RECORDS & RECORDKEEPING LAW, REGULATION, AND POLICY ASSISTANCE RECORDS ... TOP RECORDS MANAGEMENT IN THE FEDERAL GOVERNMENT It's the Law Federal agencies are ...

  13. Information Technology Management

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2013-11-21

    This revised Order is needed to clarify the roles and responsibilities, policies, and procedures for effectively managing IT investments to ensure mission success.

  14. High Performance Energy Management

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Performance Energy Management Reduce energy use and meet your business objectives By applying continuous improvement practices similar to Lean and Six Sigma, the BPA Energy Smart...

  15. Asset Management Strategies

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Efficiency and Fish and Wildlife asset categories. The CAB, in consultation with affected business units and the Asset Management Executive Sponsors, determines whether and how...

  16. Management Rachana Ananthakrishnan

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Management & Administration Forms (0000-1999) Management & Administration Forms (0000-1999) DOE F 206.1 (pdf) Privacy Impact Assessment (PIA) DOE F 206.4 (fillable pdf) Information Sheet for Sponsorship of HSPD-12 Credential DOE F 241.2 (fillable pdf) Notice of Energy RD&D Project DOE F 241.4 (fillable pdf) Announcement of Computer Software DOE F 241.5 (pdf) Information Collection Clearance Manager Appointment DOE F 242.1 (fillable pdf) Forms Manager Designation DOE F 243.2 (fillable

  17. Management's Discussion & Analysis Profile

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    in conformity with generally accepted accounting principles (GAAP) requires management to make estimates and assumptions that affect the reported amounts of assets and...

  18. Management's Discussion & Analysis Profile

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Adjusted Net Revenue is net revenue after removing the effects of certain debt management actions, in particular the Debt Service Reassignment, from prior years. These debt...

  19. Asset Management Strategies

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Asset-Management-Strategies Sign In About | Careers | Contact | Investors | bpa.gov Search News & Us Expand News & Us Projects & Initiatives Expand Projects & Initiatives...

  20. Procurement and Materials Management

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Home Washington River Protection Solutions | Hanford.gov | Energy.gov Procurement and Materials Management Small Business Resources Small ... There are no upcoming events in the system. ...

  1. Chemical Industry Corrosion Management

    SciTech Connect (OSTI)

    2003-02-01

    Improved Corrosion Management Could Provide Significant Cost and Energy Savings for the Chemical Industry. In the chemical industry, corrosion is often responsible for significant shutdown and maintenance costs.

  2. Financial Management Handbook - Complete

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ... Management of Budgetary Resources. (1) Appropriations. ... The apportionment process is detailed in DOE M 135.1-1A, ... and reporting all business transactions under the ...

  3. Project Management Practices

    Energy.gov (indexed) [DOE]

    Version) See Figure 3-3. 19. Administrative Controls 1. Provisions relating to organization and management, procedures, recordkeeping, assessment, and reporting necessary to...

  4. Office of Legacy Management

    Office of Legacy Management (LM)

    Energy Office of Legacy Management JUL 1 0 2008 Alonso Ramirez, Scientific Director EI Verde Research Station Institute for Tropical Ecosystem Studies University of Puerto Rico...

  5. Dreissenid Mussel Prevention, Management...

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Management, Research, Coordination, and Outreach for the Columbia River Basin A Roadmap to Make Strategic Investments in Federal Columbia River Power System and Technology...

  6. Dreissenid Mussel Prevention, Management, ...

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Management, Research, Coordination, and Outreach for the Columbia River Basin A Roadmap to Make Strategic Investments in Federal Columbia River Power System and Technology...

  7. Advisory Committee Management Program

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2007-10-22

    The Manual provides detailed DOE requirements, responsibilities, processes, and procedures for the establishment, operation, and management of advisory committees. Supersedes DOE M 510.1-1.

  8. Group key management

    SciTech Connect (OSTI)

    Dunigan, T.; Cao, C.

    1997-08-01

    This report describes an architecture and implementation for doing group key management over a data communications network. The architecture describes a protocol for establishing a shared encryption key among an authenticated and authorized collection of network entities. Group access requires one or more authorization certificates. The implementation includes a simple public key and certificate infrastructure. Multicast is used for some of the key management messages. An application programming interface multiplexes key management and user application messages. An implementation using the new IP security protocols is postulated. The architecture is compared with other group key management proposals, and the performance and the limitations of the implementation are described.

  9. EARNED VALUE MANAGEMENT SYSTEM

    Energy.gov (indexed) [DOE]

    ... the costs associated with the authorized resources identified to accomplish the work and invalidates management's forecasting of future resource requirements and their costs. ...

  10. ORISE: Peer Review Management

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Management Man participating in a peer review The Oak Ridge Institute for Science and Education (ORISE) ensures that scientific reviews are conducted in a professional manner and...

  11. Efficient Water Use & Management

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Water Use Goal 4: Efficient Water Use & Management Aware of the arid climate of northern New Mexico, water reduction and conservation remains a primary concern at LANL. Energy...

  12. EFRC Management Reference Document

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    EFRC management reference document Energy Frontier Research Centers Acknowledgments of Support (v.1, October 2009) Office of Basic Energy Sciences Office of Science US Department ...

  13. Grants Management Specialist

    Energy.gov [DOE]

    The Office of Science manages fundamental research programs in basic energy sciences, biological and environmental sciences, and computational science. In addition, the Office of Science is the...

  14. Enterprise Risk Management Framework

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Framework The Enterprise Risk Management (ERM) framework includes four steps: identify the risks, determine the probability and impact of each one, identify controls that are...

  15. Radioactive Waste Management

    Directives, Delegations, and Requirements [Office of Management (MA)]

    1984-02-06

    To establish policies and guidelines by which the Department of Energy (DOE) manages tis radioactive waste, waste byproducts, and radioactively contaminated surplus facilities.

  16. Records Management Program

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2006-02-03

    The Order sets forth requirements and responsibilities for implementing and maintaining a cost-effective records management program throughout the Department of Energy.

  17. Change Control Management Guide

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2011-07-29

    The Guide provides a suggested approach and uniform guidance for managing project and contract changes through applying the requirements of DOE O 413.3B. No cancellation.

  18. Records Management Program

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2011-07-26

    The Order sets forth requirements and responsibilities for establishing and maintaining a program for the efficient and economical management of records and information assets.

  19. Parallel integrated thermal management

    DOE Patents [OSTI]

    Bennion, Kevin; Thornton, Matthew

    2014-08-19

    Embodiments discussed herein are directed to managing the heat content of two vehicle subsystems through a single coolant loop having parallel branches for each subsystem.

  20. Digital Data Management Plans

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    energy physics through experiments that strengthen our fundamental understanding of matter, energy, space, and time. Plans HAWC gamma-Ray Observatory Data Management Plan (pdf)...

  1. International Commitments Management

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2008-11-18

    This Order establishes a process to manage the Department's International Commitments under the administrative direction of the Office of Policy and International Affairs. No cancellation.

  2. Waste management progress report

    SciTech Connect (OSTI)

    1997-06-01

    During the Cold War era, when DOE and its predecessor agencies produced nuclear weapons and components, and conducted nuclear research, a variety of wastes were generated (both radioactive and hazardous). DOE now has the task of managing these wastes so that they are not a threat to human health and the environment. This document is the Waste Management Progress Report for the U.S. Department of Energy dated June 1997. This progress report contains a radioactive and hazardous waste inventory and waste management program mission, a section describing progress toward mission completion, mid-year 1997 accomplishments, and the future outlook for waste management.

  3. Information Exchange management site

    Energy Science and Technology Software Center (OSTI)

    2012-08-01

    Django site used to manage the approved information exchanges (content models) after creation and public comment at https://github.com/usgin-models.

  4. Acquisition Career Management Program

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2015-05-14

    The order sets forth requirements and responsibilities for the Department of Energy (DOE) Acquisition Career Management Program. Supersedes DOE O 361.1B.

  5. Comprehensive Emergency Management System

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2005-11-02

    The Order establishes policy and assigns roles and responsibilities for the Department of Energy (DOE) Emergency Management System. Supersedes DOE O 151.1B.

  6. Management Control Program

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2002-04-18

    To establish requirements and responsibilities for the Department of Energy Management Control Program. Cancels DOE O 413.1. Canceled by DOE O 413.1B.

  7. Knockdown of hepatoma-derived growth factor-related protein-3 induces apoptosis of H1299 cells via ROS-dependent and p53-independent NF-κB activation

    SciTech Connect (OSTI)

    Yun, Hong Shik; Baek, Jeong-Hwa; Yim, Ji-Hye; Lee, Su-Jae; Lee, Chang-Woo; Song, Jie-Young; Um, Hong-Duck; Park, Jong Kuk; Park, In-Chul; Hwang, Sang-Gu

    2014-07-11

    Highlights: • HRP-3 is a radiation- and anticancer drug-responsive protein in H1299 cells. • Depletion of HRP-3 induces apoptosis of radio- and chemoresistant H1299 cells. • Depletion of HRP-3 promotes ROS generation via inhibition of the Nrf2/HO-1 pathway. • ROS generation enhances NF-κB activity, which acts as an upstream signal in the c-Myc/Noxa apoptotic pathway. - Abstract: We previously identified hepatoma-derived growth factor-related protein-3 (HRP-3) as a radioresistant biomarker in p53 wild-type A549 cells and found that p53-dependent induction of the PUMA pathway was a critical event in regulating the radioresistant phenotype. Here, we found that HRP-3 knockdown regulates the radioresistance of p53-null H1299 cells through a distinctly different molecular mechanism. HRP-3 depletion was sufficient to cause apoptosis of H1299 cells by generating substantial levels of reactive oxygen species (ROS) through inhibition of the Nrf2/HO-1 antioxidant pathway. Subsequent, ROS-dependent and p53-independent NF-κB activation stimulated expression of c-Myc and Noxa proteins, thereby inducing the apoptotic machinery. Our results thus extend the range of targets for the development of new drugs to treat both p53 wild-type or p53-null radioresistant lung cancer cells.

  8. Quality Procedure- Records Management

    Energy.gov [DOE]

    This procedure establishes the responsibilities and process for identifying and managing records, including quality records, generated by EM Headquarters Office of Standards and Quality Assurance personnel as well as Office of Standards and Quality Assurance representatives located in DOE EM Field Offices in accordance with EM-QA-001, Environmental Management Quality Assurance Program.

  9. Tribal Financial Management Symposium

    Energy.gov [DOE]

    The 3rd Annual Tribal Financial Management Symposium is a two-day event will focus on one of the most important aspects of a tribe's financial management. Attendees will learn about the state of the economy, building a financial constitution, both long- and short-term investments, alternative investment options, and much more.

  10. Information Collection Management Program

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2006-10-11

    This Order sets forth DOE requirements and responsibilities for implementing the information collection management provisions of the Paperwork Reduction Act of 1995 and the Office of Management and Budgets implementing regulation Controlling Paperwork Burdens on the Public, as contained in 5 CFR 1320. No cancellation.

  11. Risk Management Guide

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2008-09-16

    This Guide provides a framework for identifying and managing key technical, schedule, and cost risks through applying the requirements of DOE O 413.3A, Program and Project Management for the Acquisition of Capital Assets, dated 7-28-06. Canceled by DOE G 413.3-7A, dated 1-12-11. Does not cancel other directives.

  12. Integrated Landscape Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    March 23, 2015 Ian Bonner Idaho National Laboratory This presentation does not contain any proprietary, confidential, or otherwise restricted information Sustainability Technology Area 4.2.1.20 Integrated Landscape Management 2 | Bioenergy Technologies Office PROJECT GOAL * OBJECTIVE - Develop model based innovative landscape design methods that estimate increased biomass availability, improve soil, water, and air quality, and reduce grower losses through subfield management decisions.

  13. Metadata management staging system

    Energy Science and Technology Software Center (OSTI)

    2013-08-01

    Django application providing a user-interface for building a file and metadata management system. An evolution of our Node.js and CouchDb metadata management system. This one focuses on server functionality and uses a well-documented, rational and REST-ful API for data access.

  14. Comprehensive Emergency Management System

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2000-11-01

    To establish policy and to assign and describe roles and responsibilities for the Department of Energy (DOE) Emergency Management System. The Emergency Management System provides the framework for development, coordination, control, and direction of all emergency planning, preparedness, readiness assurance, response, and recovery actions. Canceled by DOE O 151.1B. Cancels DOE O 151.1.

  15. Energy Management Webinar Series

    Energy.gov [DOE]

    Boost your knowledge on how to implement an energy management system through this four-part webinar series from the Superior Energy Performance program. Each webinar introduces various elements of the ISO 50001 energy management standard—based on the Plan-Do-Check-Act approach—and the associated steps of DOE's eGuide for ISO 50001 software tool.

  16. Property Management | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Management Property Management Personal Property Management and Accountability for Headquarters Management Personal property management includes all functions necessary for the proper determination of need, source, acquisition, receipt, accountability, utilization, maintenance, rehabilitation, storage, distribution and disposal of property. Authorized Property Representatives Effective April 1, 2016: Authorized Property Pass Signers List and Accountable Property Representatives List Personal

  17. Berkeley Storage Manager

    Energy Science and Technology Software Center (OSTI)

    2007-03-01

    Storage Resource Managers (SRMs) are middleware components whose function is to provide dynamic space allocation and file management of shared storage components on the Grid, They provide storage availability for the planning and execution of a Grid job. SRMs manage two types of resources: space and files. When managing space, SRMs negotiate space allocation with the requesting client, andlor assign default space quotas. When managing files, SRMs allocate space for files, invoke file transfer servicesmore » to move files into the space. phi files for a certain lifetime, release files upon the clients’ request, and use file replacement policies to optimize the use of the shared space. SPMs can be designed to provide effective sharing of files, by monitoring the activity of shared files, and make dynamic decisions on which files to replace when space is needed. In addition, SRMs perform automatic gathage collection of unused files by removing selected files whose lifetime has expired when space is needed. BeStMan is a Java implementation of SRM functionality by the Scientific Data Management Group at LBNL. It manages multiple disks as well as the HPSS mass storage system, and can be adapted to other storage systems. The BeStMan package contains the SRM server, the SRM client tools, and SRM testing tools.« less

  18. Supply Chain Management Center | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    Supply Chain Management Center

  19. Nuclear materials management overview

    SciTech Connect (OSTI)

    DiGiallonardo, D.A. )

    1988-01-01

    The true goal of Nuclear Materials MANAGEMENT (NMM) is the strategical and economical management of all nuclear materials. Nuclear Materials Management's role involves near-term and long-term planning, reporting, forecasting, and reviewing of inventories. This function is administrative in nature. it is a growing area in need of future definition, direction, and development. Improvements are required in program structure, the way residues and wastes are determined, how ''what is and what if'' questions are handled, and in overall decision-making methods.

  20. Nuclear materials management overview

    SciTech Connect (OSTI)

    DiGiallonardo, D.A.

    1988-01-01

    The true goal of Nuclear Materials Management (NMM) is the strategical and economical management of all nuclear materials. Nuclear Materials Management's role involves near-term and long-term planning, reporting, forecasting, and reviewing of inventories. This function is administrative in nature. It is a growing area in need of future definition, direction, and development. Improvements are required in program structure, the way residues and wastes are determined, how /open quotes/What is and what if/close quotes/ questions are handled, and in overall decision-making methods. 2 refs.

  1. 2013 Program Management Review

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    BETO Project Management 2013 Program Management Review July 30, 2013 Kevin Craig - Conversion Program Manager eere.energy.gov Exploratory Research Stage A Development Research Stage B Technical Support Stage C Detailed Investigation Stage 2 Development Stage 3 Validation Stage 4 Pioneer Plant Stage 5 Preliminary Investigation Stage 1 2 3 4 5 C B A 1 Ideas "Inexpensive" based on literature, internal knowledge, "back of the envelope" $10K - $100K Show feasibility of "show-

  2. Performance Management Plan

    SciTech Connect (OSTI)

    IT Corporation, Las Vegas, NV

    2002-08-21

    This Performance Management Plan describes the approach for accelerating cleanup activities of U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Operations Office (NNSA/NV) Environmental Management (EM) Program. This approach accelerates the reduction of risk at NNSA/NV sites while performing the work responsibly, effectively, and more efficiently. In May 2002, NNSA/NV EM and the Nevada Division of Environmental Protection signed a Letter of Intent formalizing an agreement to pursue accelerated risk reduction and cleanup for activities within the State of Nevada. This Performance Management Plan provides the strategic direction for implementing the Letter of Intent.

  3. Secure Transportation Management

    SciTech Connect (OSTI)

    Gibbs, P. W.

    2014-10-15

    Secure Transport Management Course (STMC) course provides managers with information related to procedures and equipment used to successfully transport special nuclear material. This workshop outlines these procedures and reinforces the information presented with the aid of numerous practical examples. The course focuses on understanding the regulatory framework for secure transportation of special nuclear materials, identifying the insider and outsider threat(s) to secure transportation, organization of a secure transportation unit, management and supervision of secure transportation units, equipment and facilities required, training and qualification needed.

  4. Radioactive Waste Management Manual

    Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-07-09

    This Manual further describes the requirements and establishes specific responsibilities for implementing DOE O 435.1, Radioactive Waste Management, for the management of DOE high-level waste, transuranic waste, low-level waste, and the radioactive component of mixed waste. The purpose of the Manual is to catalog those procedural requirements and existing practices that ensure that all DOE elements and contractors continue to manage DOE's radioactive waste in a manner that is protective of worker and public health and safety, and the environment. Does not cancel other directives.

  5. EERE Program Management Guide - About the Program Management...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    EERE Program Management Guide - About the Program Management Guide The Introduction describes the need for an Operator's Guide, provides information on content and the relationship ...

  6. Line Management Perspective: Office of Environmental Management (EM)

    Energy.gov [DOE]

    Slide Presentation by Matthew Moury, Deputy Assistant Secretary for Safety, Security and Quality Programs, Office of Environmental Management. EFCOG Integrated Safety Management Work Planning and Control.

  7. Management Not Available 12 MANAGEMENT OF RADIOACTIVE AND NON...

    Office of Scientific and Technical Information (OSTI)

    87 Oak Ridge model conference: Proceedings: Volume I, Part 3, Waste Management Not Available 12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE WASTES FROM NUCLEAR FACILITIES; 11...

  8. Loan Specialist (Portfolio Management)

    Energy.gov [DOE]

    This position is located in the Portfolio Management Division of the U. S. Department of Energy's (DOE) Loan Programs Office (LPO). The incumbent in this position will serve as a Loan Specialist,...

  9. Transportation Management Workshop: Proceedings

    SciTech Connect (OSTI)

    Not Available

    1993-10-01

    This report is a compilation of discussions presented at the Transportation Management Workshop held in Gaithersburg, Maryland. Topics include waste packaging, personnel training, robotics, transportation routing, certification, containers, and waste classification.

  10. Acquisition and Project Management

    National Nuclear Security Administration (NNSA)

    4%2A en Acquisition and Project Management Office volunteers get up-close look at Office of Secure Transportation exercise http:nnsa.energy.govblogacquisition-and-project-mana...

  11. managing the stockpile

    National Nuclear Security Administration (NNSA)

    managed by the National Nuclear Security Administration within the U. S. Department of Energy.

    OST is responsible for the safe and secure transport in the contiguous United...

  12. Item Management Control System

    Energy Science and Technology Software Center (OSTI)

    1993-08-06

    The Item Management Control System (IMCS) has been developed at Idaho National Engineering Laboratory to assist in organizing collections of documents using an IBM-PC or similar DOS system platform.

  13. Office of Information Management

    Energy.gov [DOE]

    The Office of Information Management provides a broad range of information technology services in support of the Associate Under Secretary for the Office of Environment, Health, Safety and Security (AU).

  14. Earned Value Management

    Energy.gov [DOE]

    Earned Value Management (EVM) is a systematic approach to the integration and measurement of cost, schedule, and technical (scope) accomplishments on a project or task. It provides both the...

  15. Energy, Data Management, Reporting

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    FY 2011sales Diversified end markets - FY 2011 sales North America 23% Asia Pacific 27% Rest of World 18% Western Europe 32% - - Enterprise-wide Facility Management 4 Demographics ...

  16. Change Control Management Guide

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2011-07-29

    The Guide provides a suggested approach and uniform guidance for managing project and contract changes through applying the requirements of DOE O 413.3B. Admin Chg 1 dated 10-22-2015.

  17. Information Technology Management

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2008-12-23

    The Order identifies the objectives, components, and responsibilities for implementing processes to ensure the effective management of information and information systems within the Department. Supersedes DOE O 200.1.

  18. Office of Management

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2006-10-27

    Designates the Director, Office of Management as the DOE official responsible to perform the duties set forth in 22 CFR , sections 62.11 and 41.63 pertaining to the DOE Exchange Visitor Program,

  19. Stressor Management Video Slide

    Energy.gov [DOE]

    A video excerpt from a U.S. Fish and Wildlife Service webinar that explains the “Stressor Management Approach” to analyzing impacts to migratory birds.  The full length webinar can be viewed at...

  20. Project Management Lessons Learned

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2008-08-05

    The guide supports DOE O 413.3A, Program and Project Management for the Acquisition of Capital Assets, and aids the federal project directors and integrated project teams in the execution of projects.

  1. Management of Nuclear Materials

    Directives, Delegations, and Requirements [Office of Management (MA)]

    1994-05-26

    To establish requirements and procedures for the management of nuclear materials within the Department of Energy (DOE). Cancels DOE 5660.1A. Canceled by DOE O 410.2.

  2. 2014 Waste Management Conference

    Energy.gov [DOE]

    When you hear about the U.S. Department of Energy (DOE) Office of Legacy Management (LM), what comes to mind? Is it long-term surveillance and maintenance (LTS&M) activities such as conducting...

  3. Human Resource Management Delegation

    Directives, Delegations, and Requirements [Office of Management (MA)]

    1996-06-28

    The notice is to clarifies and updates existing Human Resource Management Delegation Authorities and the levels to which they are delegated. Expired 6-28-97. Does not cancel any directives.

  4. ENVIRONMENTAL MANAGEMENT ADVISORY BOARD

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    EM Update and Discussion of Charges to the Board Mark Whitney, Principal Deputy Assistant Secretary for Environmental Management 2:30 p.m. Break 2:45 p.m. Public Comment Period ...

  5. Headquarters Personal Property Management

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2004-10-25

    To establish procedures for managing Government personal property owned or leased by the Department of Energy and in the custody of DOE Headquarters employees, including those in the National Nuclear Security Administration. Cancels DOE HQ O 580.1A

  6. Comprehensive Emergency Management System

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2016-08-11

    The Order establishes policy and assigns roles and responsibilities for the Department of Energy (DOE) Emergency Management System. Supersedes DOE O 151.1C. Cancels DOE M 151.1-1.

  7. Strategic Energy Management

    Energy.gov [DOE]

    The U.S. Department of Energy (DOE) SEE Action Network and Weatherization and Intergovernmental Program Technical Assistance Program sponsored this webinar about strategic management in the public sector on November 7, 2012.

  8. Waste Management | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Management Waste Management Oak Ridge has an onsite CERCLA disposal facility, the Environmental Management Waste Management Facility, that reduces cleanup and transportation costs. Oak Ridge has an onsite CERCLA disposal facility, the Environmental Management Waste Management Facility, that reduces cleanup and transportation costs. Years of diverse research and uranium and isotope production led to numerous forms of waste in Oak Ridge. However, our EM program has worked to identify,

  9. Carlsbad Field Office Manager Selected

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Carlsbad Field Office Manager Selected CARLSBAD, N.M., November 10, 2011 - The U.S. Department of Energy's (DOE) Richland Operations Office (RL) Assistant Manager for the River Corridor Joe Franco was selected as Manager for the Carlsbad Field Office (CBFO), which oversees the Waste Isolation Pilot Plant (WIPP). CBFO Deputy Manager Ed Ziemianski has been acting in the CBFO Manager's position for the past year and will continue to serve as Deputy Manager. In operation since 1999, WIPP is a DOE

  10. Personal Property Management Program Brochure | Department of...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Personal Property Management Program Brochure Personal Property Management Program Brochure PDF icon Personal Property Management Program Brochure More Documents & Publications...

  11. Software Configuration Management Plan | Department of Energy

    Energy Savers

    Software Configuration Management Plan Software Configuration Management Plan This template is used for documenting the configuration management methodology, tools, techniques, ...

  12. Environmental Management Associates | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Environmental Management Associates Jump to: navigation, search Name: Environmental Management Associates Abbreviation: EMA Website: www.emacorp.com Environmental Management...

  13. Project Management Career Development Program | Department of...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    are here Home Operational Management Certifications and Professional Development Project Management Career Development Program Project Management Career Development...

  14. Acquisition and Project Management Continuous Improvement Presentation...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    and Project Management Continuous Improvement Presentation Acquisition and Project Management Continuous Improvement Presentation Presentation on Acquisition and Project Management ...

  15. Environmental Management Advisory Board Subcommittees | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    EMAB Environmental Management Advisory Board Subcommittees Environmental Management Advisory Board Subcommittees ACQUISITION AND PROJECT MANAGEMENT SUBCOMMITTEE SUBCOMMITTEE ...

  16. Project Management Resources | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Project Management Resources Project Management Resources Performance & Project Completion Environmental Management Completed Projects 2005-Present EM Current Project Performance ...

  17. Management Control Cover

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Assess- ing Natural Resource Damage at Rocky Flats OAS-M-06-02 November 2005 REPORT ON MANAGEMENT CONTROLS OVER ASSESSING NATURAL RESUORCE DAMAGE AT ROCKY FLATS TABLE OF CONTENTS Natural Resource Damage Assessment at Rocky Flats Details of Finding 1 Recommendation and Comments 3 Appendices Objective, Scope, and Methodology 5 Prior Audit Reports 6 Management Comments 7 NATURAL RESURCE DAMAGE ASSESSMENT AT ROCKY FLATS Page 1 Details of Finding Natural Resource The Rocky Flats Project Office

  18. The Utility Management Conference

    Energy.gov [DOE]

    The Utility Management Conference™ 2016 in San Diego is the place to be for leading utility and consulting staff. The technical program has been expanded to 36 sessions running in four concurrent rooms in order to provide utility leaders with the latest tools, techniques, best practices, and emerging solutions you need for effective utility management. This event will empower attendees, leading the water sector “On the Road to the Utilities of the Future.”

  19. TWRS safety management plan

    SciTech Connect (OSTI)

    Popielarczyk, R.S., Westinghouse Hanford

    1996-08-01

    The Tank Waste Remediation System (TWRS) Safety Management Program Plan for development, implementation and maintenance of the tank farm authorization basis is described. The plan includes activities and procedures for: (a) Updating the current Interim Safety Basis, (b) Development,implementation and maintenance of a Basis for Interim Operations, (c) Development, implementation and maintenance of the Final Safety Analyses Report, (d) Development and implementation of a TWRS information Management System for monitoring the authorization basis.

  20. ENVIRONMENTAL MANAGEMENT ADVISORY BOARD

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ENVIRONMENTAL MANAGEMENT ADVISORY BOARD to the U.S. DEPARTMENT OF ENERGY PUBLIC MEETING MINUTES Applied Research Center 301 Gateway Drive, Aiken, South Carolina 29803 May 11, 2016 2 PROCEEDINGS Ms. Kristen Ellis, the EMAB Designated Federal Officer called the Environmental Management Advisory Board meeting to order at 9:00 a.m. EST on Wednesday, May 11, 2016. Board members present: Mr. Sherrell R. Greene, Advanced Technology Insights, LLC Ms. Jane Hedges, Consultant Dr. Carolyn Huntoon,

  1. Lithium battery management system

    DOE Patents [OSTI]

    Dougherty, Thomas J.

    2012-05-08

    Provided is a system for managing a lithium battery system having a plurality of cells. The battery system comprises a variable-resistance element electrically connected to a cell and located proximate a portion of the cell; and a device for determining, utilizing the variable-resistance element, whether the temperature of the cell has exceeded a predetermined threshold. A method of managing the temperature of a lithium battery system is also included.

  2. Radioactive Waste Management Manual

    Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-07-09

    This Manual further describes the requirements and establishes specific responsibilities for implementing DOE O 435.1, Radioactive Waste Management, for the management of DOE high-level waste, transuranic waste, low-level waste, and the radioactive component of mixed waste. Change 1 dated 6/19/01 removes the requirement that Headquarters is to be notified and the Office of Environment, Safety and Health consulted for exemptions for use of non-DOE treatment facilities. Certified 1-9-07.

  3. Turbine Thermal Management

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Turbine Thermal Management Fact Sheets Research Team Members Key Contacts Turbine Thermal Management The gas turbine is the workhorse of power generation, and technology advances to current land-based turbines are directly linked to our country's economic and energy security. Technical advancement for any type of gas turbine generally implies better performance, greater efficiency, and extended component life. From the standpoint of cycle efficiency and durability, this suggests that a continual

  4. Environmental Management System

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Energy Environmental Management Scientist Sets His Sights on Mars Environmental Management Scientist Sets His Sights on Mars September 4, 2012 - 3:29pm Addthis Curiosity, left, at NASA’s Jet Propulsion Laboratory in Pasadena, California, in late November 2011. Shown here is the flight hardware that was being assembled prior to shipment to Cape Canaveral Air Force Station in Florida for the launch. | Photo Credit Dr. Robert C. Nelson Curiosity, left, at NASA's Jet Propulsion Laboratory

  5. Issues Management Tool

    Energy Science and Technology Software Center (OSTI)

    2010-12-31

    IMTool performs the following: • The IMTool can manage issues, actions, and activities from one screen. • Provides enhanced and intuitive searching, sorting, and filtering capabilities. Grids allow for filtering any column instantly by any data heading. • IMTool uses drop-down menus to ensure date is entered accurately with consistency. • User-friendly system – highly utilized commitment tracking screen functions. Information is viewed on the left side of the screen and managed on the right.

  6. Safety Management System Policy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Health, Safety and Security U.S. Department of Energy POLICY Washington, D.C. Approved: 4-25-11 SUBJECT: INTEGRATED SAFETY MANAGEMENT POLICY PURPOSE AND SCOPE To establish the Department of Energy's (DOE) expectation for safety, 1 including integrated safety management that will enable the Department's mission goals to be accomplished efficiently while ensuring safe operations at all departmental facilities and activities. This Policy cancels and supersedes DOE Policy (P) 411.1, Safety

  7. Project Management Policies & Principles Memo

    Energy.gov [DOE]

    Memo enhances and clarifies departmental policy related to project management as a result of the Improving Project Management Study and subsequent Secretarial Memo dated December 2014.

  8. Vantage Management | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Management Jump to: navigation, search Name: Vantage Management Place: New York Product: US-based firm which provides business and technical consulting to growing companies....

  9. Claridge Management | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Claridge Management Jump to: navigation, search Name: Claridge Management Place: United Kingdom Product: Claridge is focusing on setting up incubatortechnology development hubs in...

  10. Data Management at the ALS

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Data Management at the ALS Print Users of the ALS are responsible for meeting their data management obligations to their home institutions and granting agencies. Except as noted ...

  11. Performance Management | Department of Energy

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Performance Management Performance Management Documents available for download November ... concludes on December 15, 2015. These documents provide a detailed overview of both ...

  12. Earned Value Management System RM

    Office of Environmental Management (EM)

    and Project Management for the Acquisition of Capital Assets, DOE-STD-1189-2008, Integration of Safety into the Design Process, and EM's internal business management practices. ...

  13. Fleet Management | Department of Energy

    Energy.gov (indexed) [DOE]

    Fleet management includes commercial and agency owned motor vehicles such as cars, vans, trucks, and buses. Fleet (vehicle) management at the headquarters level includes a range of...

  14. Consequence Management Response Team | National Nuclear Security

    National Nuclear Security Administration (NNSA)

    Administration Consequence Management Response

  15. Risk Management Process Overview | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Risk Management Process Overview Risk Management Process Overview figure depicting three tier risk management process The cybersecurity risk management process explained in the ...

  16. Waste Management Committee | Department of Energy

    Office of Environmental Management (EM)

    Waste Management Committee Waste Management Committee Waste Management Committee Waste Management Committee Mission Statement The Northern New Mexico Citizens' Advisory Board ...

  17. Waste Management Update by Frank Marcinowski

    Office of Environmental Management (EM)

    U.S. DOE Environmental Management Update on Waste Management (and other EM Mission Units) Frank Marcinowski Deputy Assistant Secretary for Waste Management ENVIRONMENTAL MANAGEMENT ...

  18. OFFICE OF ENVIRONMENTAL MANAGEMENT NAMES NEW IDAHO CLEANUP MANAGER

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Danielle Miller (208) 526-5709 For Immediate Release May 30, 2014 OFFICE OF ENVIRONMENTAL MANAGEMENT NAMES NEW IDAHO CLEANUP MANAGER Idaho Falls, ID - The U.S. Department of Energy Office of Environmental Management today announced that John (Jack) Zimmerman has been named Deputy Manager of its highly-successful Idaho Cleanup program, which oversees the environmental cleanup and waste management mission at DOE's Idaho site. Mr. Zimmerman has more than 25 years of experience in nuclear

  19. Analytical Services Management System

    Energy Science and Technology Software Center (OSTI)

    2005-03-30

    Analytical Services Management System (ASMS) provides sample management services. Sample management includes sample planning for analytical requests, sample tracking for shipping and receiving by the laboratory, receipt of the analytical data deliverable, processing the deliverable and payment of the laboratory conducting the analyses. ASMS is a web based application that provides the ability to manage these activities at multiple locations for different customers. ASMS provides for the assignment of single to multiple samples for standardmore » chemical and radiochemical analyses. ASMS is a flexible system which allows the users to request analyses by line item code. Line item codes are selected based on the Basic Ordering Agreement (BOA) format for contracting with participating laboratories. ASMS also allows contracting with non-BOA laboratories using a similar line item code contracting format for their services. ASMS allows sample and analysis tracking from sample planning and collection in the field through sample shipment, laboratory sample receipt, laboratory analysis and submittal of the requested analyses, electronic data transfer, and payment of the laboratories for the completed analyses. The software when in operation contains business sensitive material that is used as a principal portion of the Kaiser Analytical Management Services business model. The software version provided is the most recent version, however the copy of the application does not contain business sensitive data from the associated Oracle tables such as contract information or price per line item code.« less

  20. Analytical Services Management System

    SciTech Connect (OSTI)

    Church, Shane; Nigbor, Mike; Hillman, Daniel

    2005-03-30

    Analytical Services Management System (ASMS) provides sample management services. Sample management includes sample planning for analytical requests, sample tracking for shipping and receiving by the laboratory, receipt of the analytical data deliverable, processing the deliverable and payment of the laboratory conducting the analyses. ASMS is a web based application that provides the ability to manage these activities at multiple locations for different customers. ASMS provides for the assignment of single to multiple samples for standard chemical and radiochemical analyses. ASMS is a flexible system which allows the users to request analyses by line item code. Line item codes are selected based on the Basic Ordering Agreement (BOA) format for contracting with participating laboratories. ASMS also allows contracting with non-BOA laboratories using a similar line item code contracting format for their services. ASMS allows sample and analysis tracking from sample planning and collection in the field through sample shipment, laboratory sample receipt, laboratory analysis and submittal of the requested analyses, electronic data transfer, and payment of the laboratories for the completed analyses. The software when in operation contains business sensitive material that is used as a principal portion of the Kaiser Analytical Management Services business model. The software version provided is the most recent version, however the copy of the application does not contain business sensitive data from the associated Oracle tables such as contract information or price per line item code.

  1. Environmental Requirements Management

    SciTech Connect (OSTI)

    Cusack, Laura J.; Bramson, Jeffrey E.; Archuleta, Jose A.; Frey, Jeffrey A.

    2015-01-08

    CH2M HILL Plateau Remediation Company (CH2M HILL) is the U.S. Department of Energy (DOE) prime contractor responsible for the environmental cleanup of the Hanford Site Central Plateau. As part of this responsibility, the CH2M HILL is faced with the task of complying with thousands of environmental requirements which originate from over 200 federal, state, and local laws and regulations, DOE Orders, waste management and effluent discharge permits, Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) response and Resource Conservation and Recovery Act (RCRA) corrective action documents, and official regulatory agency correspondence. The challenge is to manage this vast number of requirements to ensure they are appropriately and effectively integrated into CH2M HILL operations. Ensuring compliance with a large number of environmental requirements relies on an organization’s ability to identify, evaluate, communicate, and verify those requirements. To ensure that compliance is maintained, all changes need to be tracked. The CH2M HILL identified that the existing system used to manage environmental requirements was difficult to maintain and that improvements should be made to increase functionality. CH2M HILL established an environmental requirements management procedure and tools to assure that all environmental requirements are effectively and efficiently managed. Having a complete and accurate set of environmental requirements applicable to CH2M HILL operations will promote a more efficient approach to: • Communicating requirements • Planning work • Maintaining work controls • Maintaining compliance

  2. Management control system description

    SciTech Connect (OSTI)

    Bence, P. J.

    1990-10-01

    This Management Control System (MCS) description describes the processes used to manage the cost and schedule of work performed by Westinghouse Hanford Company (Westinghouse Hanford) for the US Department of Energy, Richland Operations Office (DOE-RL), Richland, Washington. Westinghouse Hanford will maintain and use formal cost and schedule management control systems, as presented in this document, in performing work for the DOE-RL. This MCS description is a controlled document and will be modified or updated as required. This document must be approved by the DOE-RL; thereafter, any significant change will require DOE-RL concurrence. Westinghouse Hanford is the DOE-RL operations and engineering contractor at the Hanford Site. Activities associated with this contract (DE-AC06-87RL10930) include operating existing plant facilities, managing defined projects and programs, and planning future enhancements. This document is designed to comply with Section I-13 of the contract by providing a description of Westinghouse Hanford's cost and schedule control systems used in managing the above activities. 5 refs., 22 figs., 1 tab.

  3. Management Reminders | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Management Reminders Management Reminders This document is normally shared by the HQ Program Manager a week prior to the scheduled mediation and is intented to serve as a reminder of the pertinent aspects of the mediation process. ADRO-HQ-006 Final - Management Reminders.pdf (87.03 KB) More Documents & Publications Employee Reminders Mediation Process Mediator

  4. DOE Project Management Update (Metrics)

    Energy.gov [DOE]

    Michael Peek, Deputy Director, Office of Project Management Oversight and Assessments March 22, 2016

  5. Environmental Management Disposal Facility overview

    Energy.gov [DOE]

    This fact sheet provides a brief overview for the need behind the Environmental Management Disposal Facility.

  6. TWRS Configuration management program plan

    SciTech Connect (OSTI)

    Vann, J.M.

    1996-06-03

    The TWRS Configuration Management Program Plan (CMPP) integrates technical and administrative controls to establish and maintain consistency among requirements, product configuration, and product information for TWRS products during all life cycle phases. This CMPP will be used by TWRS management and configuration management personnel to establish and manage the technical and integrated baselines and controls and status changes to those baselines.

  7. Storage resource manager

    SciTech Connect (OSTI)

    Perelmutov, T.; Bakken, J.; Petravick, D.; /Fermilab

    2004-12-01

    Storage Resource Managers (SRMs) are middleware components whose function is to provide dynamic space allocation and file management on shared storage components on the Grid[1,2]. SRMs support protocol negotiation and reliable replication mechanism. The SRM standard supports independent SRM implementations, allowing for a uniform access to heterogeneous storage elements. SRMs allow site-specific policies at each location. Resource Reservations made through SRMs have limited lifetimes and allow for automatic collection of unused resources thus preventing clogging of storage systems with ''orphan'' files. At Fermilab, data handling systems use the SRM management interface to the dCache Distributed Disk Cache [5,6] and the Enstore Tape Storage System [15] as key components to satisfy current and future user requests [4]. The SAM project offers the SRM interface for its internal caches as well.

  8. Computer memory management system

    DOE Patents [OSTI]

    Kirk, III, Whitson John

    2002-01-01

    A computer memory management system utilizing a memory structure system of "intelligent" pointers in which information related to the use status of the memory structure is designed into the pointer. Through this pointer system, The present invention provides essentially automatic memory management (often referred to as garbage collection) by allowing relationships between objects to have definite memory management behavior by use of coding protocol which describes when relationships should be maintained and when the relationships should be broken. In one aspect, the present invention system allows automatic breaking of strong links to facilitate object garbage collection, coupled with relationship adjectives which define deletion of associated objects. In another aspect, The present invention includes simple-to-use infinite undo/redo functionality in that it has the capability, through a simple function call, to undo all of the changes made to a data model since the previous `valid state` was noted.

  9. Oil field management system

    DOE Patents [OSTI]

    Fincke, James R.

    2003-09-23

    Oil field management systems and methods for managing operation of one or more wells producing a high void fraction multiphase flow. The system includes a differential pressure flow meter which samples pressure readings at various points of interest throughout the system and uses pressure differentials derived from the pressure readings to determine gas and liquid phase mass flow rates of the high void fraction multiphase flow. One or both of the gas and liquid phase mass flow rates are then compared with predetermined criteria. In the event such mass flow rates satisfy the predetermined criteria, a well control system implements a correlating adjustment action respecting the multiphase flow. In this way, various parameters regarding the high void fraction multiphase flow are used as control inputs to the well control system and thus facilitate management of well operations.

  10. Berkeley Disk Resource Manager

    SciTech Connect (OSTI)

    2004-02-27

    The Berkeley Disk Resource Manager (B-DRM) is a middleware component whose function is to provide dynamic space allocation and file management of a shared disk system on the Grid. It provides space allocation and dynamic information on storage availability for the planning and execution of Grid jobs. The B-DRM manages two types of resources: space and files. Vi1en managing space, the B-DRM allocates space to the requesting client based on a default space quota, Then managing files, the B-DRM allocates space for files, invokes file transfer services to move files into the space, pins files for a certain lifetime, releases files upon the client?s request, and uses file replacement policies to optimize the use of the shared space. The B-DRM is designed to provide effective sharing of files, by monitoring the activity of shared files, and making dynamic decisions on which files to replace when space is needed. In addition, the B-DRM performs automatic garbage collection of unused files when space is needed by removing selected files that were released by the client or whose lifetime has expired. The BDRM supports requests to get multiple files in a single call, manages a queue of the requested files, brings in as many files as the space quota permits, and continues to reuse the space when files are released to stream files to the client until the entire request is satisfied. Similarly, the B-DRM supports requests to put multiple files into its space, streaming files into the allocated space and reusing the space if necessary.

  11. Berkeley Disk Resource Manager

    Energy Science and Technology Software Center (OSTI)

    2004-02-27

    The Berkeley Disk Resource Manager (B-DRM) is a middleware component whose function is to provide dynamic space allocation and file management of a shared disk system on the Grid. It provides space allocation and dynamic information on storage availability for the planning and execution of Grid jobs. The B-DRM manages two types of resources: space and files. Vi1en managing space, the B-DRM allocates space to the requesting client based on a default space quota, Thenmore » managing files, the B-DRM allocates space for files, invokes file transfer services to move files into the space, pins files for a certain lifetime, releases files upon the client’s request, and uses file replacement policies to optimize the use of the shared space. The B-DRM is designed to provide effective sharing of files, by monitoring the activity of shared files, and making dynamic decisions on which files to replace when space is needed. In addition, the B-DRM performs automatic garbage collection of unused files when space is needed by removing selected files that were released by the client or whose lifetime has expired. The BDRM supports requests to get multiple files in a single call, manages a queue of the requested files, brings in as many files as the space quota permits, and continues to reuse the space when files are released to stream files to the client until the entire request is satisfied. Similarly, the B-DRM supports requests to put multiple files into its space, streaming files into the allocated space and reusing the space if necessary.« less

  12. Aviation Management | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Management » Aviation Management Aviation Management The Department of Energy, Aviation Program is the management function for all fleet aircraft and contracted aviation services for the Department. The program and its management personnel operate world-wide. To take advantage of the best communications and information services available, we have chosen the Net as one of our mainstays. The services provided from this page are designed to support our operating personnel. Except for our licensed

  13. Fleet Management | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Property » Fleet Management Fleet Management Fleet management includes commercial and agency owned motor vehicles such as cars, vans, trucks, and buses. Fleet (vehicle) management at the headquarters level includes a range of functions, such as vehicle data base management of the FAST, FMVRS, FedFMS, and UNICOR systems, annual motor vehicle utilization and budget forecast data, as well as the use and monitoring of GSA systems in their Fleet DriveThru data base. The DOE Fleet Handbook

  14. Operational Management | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Management Operational Management The Office of Management supports many leadership responsibilities for the Department of Energy (DOE), providing support for project and contract management and other administrative functions. For example, the office oversees more than $22 billion in annual contract obligations and $2 billion in financial assistance obligations. It supports the management of the Department's multi-billion dollar project portfolio, and provides the Secretary of Energy and senior

  15. Hoffman Joins Safety Management Elite

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Hoffman Joins Safety Management Elite CARLSBAD, N.M., June 21, 2001 - Paul Hoffman of Westinghouse TRU Solutions LLC (WTS) has joined the ranks of the safety management elite in the United States by earning his Certificate in Safety Management. WTS is the management and operating contractor for the U.S. Department of Energy at the Waste Isolation Pilot Plant (WIPP). The Certificate in Safety Management is awarded by the American Society of Safety Engineers (ASSE) to recognize completion of

  16. Radioactive Waste Management Manual

    Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-07-09

    This Manual further describes the requirements and establishes specific responsibilities for implementing DOE O 435.1, Radioactive Waste Management, for the management of DOE high-level waste, transuranic waste, low-level waste, and the radioactive component of mixed waste. Change 1 dated 6/19/01 removes the requirement that Headquarters is to be notified and the Office of Environment, Safety and Health consulted for exemptions for use of non-DOE treatment facilities. Certified 1-9-07. Admin Chg 2, dated 6-8-11, supersedes DOE M 435.1-1 Chg 1.

  17. Contract/Project Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    8 4 th Quarter Metrics Final Overall Contract and Project Management Performance Metrics and Targets Contract/Project Management Performance Metrics FY 2008 Target FY 2008 Actual Comment 1. Capital Asset Line Item Projects: 90% of projects completed within 110% of CD-2 TPC by FY11. 75% 76% This is a 3-year rolling average Data includes FY06 to FY08. (37/48) 2. EM Cleanup (Soil and Groundwater Remediation, D&D, and Waste Treatment and Disposal) Projects: 90% of EM cleanup projects complete

  18. Contract/Project Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    1 st Quarter Overall Contract and Project Management Performance Metrics and Targets Contract/Project Management Performance Metrics FY 2009 Target FY 2009 Actual Comment 1. Capital Asset Line Item Projects: 90% of projects completed within 110% of CD-2 TPC by FY11. 80% - No 1 st Qtr FY09 completions. This is a 3-year rolling average (FY07 to FY09). 2. EM Cleanup (Soil and Groundwater Remediation, D&D, and Waste Treatment and Disposal) Projects: 90% of EM cleanup projects complete 80% of

  19. Contract/Project Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    2 nd Quarter Overall Contract and Project Management Performance Metrics and Targets Contract/Project Management Performance Metrics FY 2009 Target FY 2009 Actual Comment 1. Capital Asset Line Item Projects: 90% of projects completed within 110% of CD-2 TPC by FY11. 80% - Two projects completed in the 2 nd Qtr FY09. This is a 3-year rolling average (FY07 to FY09). 2. EM Cleanup (Soil and Groundwater Remediation, D&D, and Waste Treatment and Disposal) Projects: 90% of EM cleanup projects

  20. Contract/Project Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    3 rd Quarter Overall Contract and Project Management Performance Metrics and Targets Contract/Project Management Performance Metrics FY 2009 Target FY 2009 Actual Comment 1. Capital Asset Line Item Projects: 90% of projects completed within 110% of CD-2 TPC by FY11. 80% 72% This is a 3-year rolling average (FY07 to FY09). No 3 rd qtr FY09 completions. 2. EM Cleanup (Soil and Groundwater Remediation, D&D, and Waste Treatment and Disposal) Projects: 90% of EM cleanup projects complete 80% of

  1. Contract/Project Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Second Quarter Overall Contract and Project Management Performance Metrics and Targets 1 Contract/Project Management Primary Performance Metrics FY 2010 Target FY 2010 Actual FY 2010 Pre- & Post-CAP Comment 1a. Capital Asset Line Item Projects: (Pre-RCA/CAP) 90% of projects completed within 110% of CD-2 TPC by FY11. 1b. Capital Asset Line Item Projects: (Post-RCA/CAP) 85% Line Item 73% Line Item 70% Pre-CAP 100% Post-CAP This is a projection based on a 3-year rolling average (FY08 to FY10).

  2. Contract/Project Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Third Quarter Overall Contract and Project Management Performance Metrics and Targets 1 Contract/Project Management Primary Performance Metrics FY 2010 Target FY 2010 Forecast FY 2010 Pre- & Post-CAP Comment 1a. Capital Asset Line Item Projects: (Pre-RCA/CAP) 90% of projects completed within 110% of CD-2 TPC by FY11. 1b. Capital Asset Line Item Projects: (Post-RCA/CAP) 85% Line Item 71% Line Item 70% Pre-CAP 100% Post-CAP This is a projection based on a 3-year rolling average (FY08 to FY10).

  3. Contract/Project Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Fourth Quarter Overall Contract and Project Management Performance Metrics and Targets 1 Contract/Project Management Primary Performance Metrics FY 2010 Target FY 2010 Actual FY 2010 Pre- & Post-CAP Comment 1a. Capital Asset Line Item Projects: (Pre-RCA/CAP) 90% of projects completed within 110% of CD-2 TPC by FY11. 1b. Capital Asset Line Item Projects: (Post-RCA/CAP) 85% Line Item 69% Line Item 67% Pre-CAP 100% Post-CAP This is based on a 3-year rolling average (FY08 to FY10). TPC is Total

  4. Contract/Project Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    First Quarter Overall Contract and Project Management Performance Metrics and Targets 1 Contract/Project Management Primary Performance Metrics FY 2011 Target FY 2011 Actual & Forecast FY 2011 Pre- & Post-CAP Comment 1a. Capital Asset Line Item Projects: (Pre-RCA/CAP) Projects completed within 110% of CD-2 TPC. 1b. Capital Asset Line Item Projects: (Post-RCA/CAP) 90% Line Item 79% Line Item 71% Pre-CAP 100% Post-CAP This is based on a 3-year rolling average (FY09 to FY11). TPC is Total

  5. Contract/Project Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Second Quarter Overall Contract and Project Management Improvement Performance Metrics and Targets 1 Contract/Project Management Primary Performance Metrics FY 2011 Target FY 2011 Forecast FY 2011 Pre- & Post-CAP Forecast Comment 1a. Capital Asset Line Item Projects: (Pre-RCA/CAP) Projects completed within 110% of CD-2 TPC. 1b. Capital Asset Line Item Projects: (Post-RCA/CAP) 90% Line Item 84% Line Item 78% Pre-CAP 100% Post-CAP This is based on a 3-year rolling average (FY09 to FY11). TPC

  6. Contract/Project Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Third Quarter Overall Contract and Project Management Improvement Performance Metrics and Targets 1 Contract/Project Management Primary Performance Metrics FY 2011 Target FY 2011 Forecast FY 2011 Pre- & Post-CAP Forecast Comment 1a. Capital Asset Line Item Projects: (Pre-RCA/CAP) Projects completed within 110% of CD-2 TPC. 1b. Capital Asset Line Item Projects: (Post-RCA/CAP) 90% Line Item 84% Line Item 78% Pre-CAP 100% Post-CAP This is based on a 3-year rolling average (FY09 to FY11). TPC is

  7. Contract/Project Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Fourth Quarter Overall Contract and Project Management Improvement Performance Metrics and Targets 1 Contract/Project Management Primary Performance Metrics FY 2011 Target FY 2011 Actual FY 2011 Pre- & Post-CAP Actual Comment 1a. Capital Asset Line Item Projects: (Pre-RCA/CAP) Projects completed within 110% of CD-2 TPC. 1b. Capital Asset Line Item Projects: (Post-RCA/CAP) 90% Line Item 84% Line Item 77% Pre-CAP 100% Post-CAP This is based on a 3-year rolling average (FY09 to FY11). TPC is

  8. Contract/Project Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    First Quarter Overall Contract and Project Management Improvement Performance Metrics and Targets 1 Contract/Project Management Performance Metric FY 2012 Target FY 2012 Forecast FY 2012 Pre- & Post-CAP Forecast Comment Capital Asset Project Success: Complete 90% of capital asset projects at original scope and within 110% of CD-2 TPC. 90%* 84% Construction 83% Cleanup 85% 77% Pre-CAP 86% Post- CAP This is based on a 3- year rolling average (FY10 to FY12). TPC is Total Project Cost.

  9. Contract/Project Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Second Quarter Overall Contract and Project Management Improvement Performance Metrics and Targets 1 Contract/Project Management Performance Metric FY 2012 Target FY 2012 Forecast FY 2012 Pre- & Post-CAP Forecast Comment Capital Asset Project Success: Complete 90% of capital asset projects at original scope and within 110% of CD-2 TPC. 90%* 88% Construction 87% Cleanup 89% 77% Pre-CAP 92% Post- CAP This is based on a 3- year rolling average (FY10 to FY12). TPC is Total Project Cost.

  10. Contract/Project Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Third Quarter Overall Contract and Project Management Improvement Performance Metrics and Targets 1 Contract/Project Management Performance Metric FY 2012 Target FY 2012 Forecast FY 2012 Pre- & Post-CAP Forecast Comment Capital Asset Project Success: Complete 90% of capital asset projects at original scope and within 110% of CD-2 TPC. 90%* 87% Construction 87% Cleanup 87% 77% Pre-CAP 90% Post- CAP This is based on a 3- year rolling average (FY10 to FY12). TPC is Total Project Cost.

  11. Contract/Project Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Fourth Quarter Overall Contract and Project Management Improvement Performance Metrics and Targets 1 Contract/Project Management Performance Metric FY 2012 Target FY 2012 Final FY 2012 Pre- & Post-CAP Final Comment Capital Asset Project Success: Complete 90% of capital asset projects at original scope and within 110% of CD-2 TPC. 90%* 86% Construction 87% Cleanup 84% 77% Pre-CAP 89% Post-CAP This is based on a 3- year rolling average (FY10 to FY12). TPC is Total Project Cost.

  12. Monitoring and Managing Jobs

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Jobs Monitoring and Managing Jobs Monitoring and Managing Batch Jobs These are some basic commands for monitoring and modifiying batch jobs while they're queued or running. NERSC has developed a new tool for monitoring and viewing the state of batch jobs for genepool called qs. Please read about Monitoring jobs with qs Action How to do it Comment Get a listing of your jobs and their states qs -u If you skip the -u option, you'll get all the jobs on Genepool/Phoebe. qstat -u user_name If you skip

  13. Monitoring and Managing Jobs

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Monitoring and Managing Jobs Monitoring and Managing Jobs Commonly Used Commands Action How to do it Comment Get a summary of all batch jobs sgeusers Shows a tally of all jobs for all users including their states. This is a script that parses the output of qstat and is maintained by PDSF staff (located in /common/usg/bin). Do "sgeusers -h" for usage info. Get a listing of your jobs and their states qstat -u user_name If you skip the -u option, you'll get all the jobs on PDSF. Get

  14. 2014 DEPARTMENT OF ENERGY PROJECT MANAGEMENT WORKSHOP

    Energy.gov [DOE]

    What:  2014 DOE Project Management Workshop (Meeting the Challenge—Integrated Acquisition & Project Management)

  15. Emergency Management Concepts, Existing Guidance, and Changes

    Energy.gov [DOE]

    Presenter: David Freshwater, Emergency Management Specialist, Office of Emergency Management, National Nuclear Security Administration

  16. Contractor Legal Management Requirements

    Energy.gov [DOE]

    The purpose of this flash is to inform you of the issuance of two new Acquisition Guide Chapters, Chapters 70-31 C and 31.3, both titled "Contractor Legal Management Requirements." (Chapter 31.3 simply refers you to Chapter 70-31 C.)

  17. Integrated Safety Management

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2011-04-25

    The order ensures that DOE/NNSA, systematically integrates safety into management and work practices at all levels, so that missions are accomplished efficiently while protecting the workers, the public, and the environment. Supersedes DOE M 450.4-1 and DOE M 411.1-1C

  18. Integrated Safety Management Policy

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2011-04-25

    The policy establishes DOE's expectation for safety, including integrated safety management that will enable the Department’s mission goals to be accomplished efficiently while ensuring safe operations at all departmental facilities and activities. Supersedes DOE P 450.4, DOE P 411.1, DOE P 441.1, DOE P 450.2A, and DOE P 450.7

  19. Radioactive Waste Management

    Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-07-09

    The objective of this Order is to ensure that all Department of Energy (DOE) radioactive waste is managed in a manner that is protective of worker and public health and safety and the environment. Supersedes DOE O 5820.2A. Chg 1 dated 8-28-01. Certified 1-9-07.

  20. Position Management and Classification

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2015-04-01

    The order establishes departmental requirements and responsibilities for classifying positions using general schedule (GS) and federal wage system (FWS) standards and for developing and administering a sound position management and classification program within the Department. Cancels Chapter VII of DOE O 320.1. Canceled by DOE O 325.2 Chg 1 (Admin Chg), 9-1-15.

  1. OFFICE FOR EMERGENCY MANAGEMENT

    Office of Legacy Management (LM)

    OFFICE FOR EMERGENCY MANAGEMENT 155OP STREETNW. WiSHINGTON. D.C. ' , iQns 25,19&L At-t :. I' .' at l530 P Btmat, IO&, XtwMn&m, 0. 6., at 9130 A.Jb Sa 1 llmbemupoftbaaomlttaal8f...

  2. Purge water management system

    DOE Patents [OSTI]

    Cardoso-Neto, Joao E.; Williams, Daniel W.

    1996-01-01

    A purge water management system for effectively eliminating the production of purge water when obtaining a groundwater sample from a monitoring well. In its preferred embodiment, the purge water management system comprises an expandable container, a transportation system, and a return system. The purge water management system is connected to a wellhead sampling configuration, typically permanently installed at the well site. A pump, positioned with the monitoring well, pumps groundwater through the transportation system into the expandable container, which expands in direct proportion with volume of groundwater introduced, usually three or four well volumes, yet prevents the groundwater from coming into contact with the oxygen in the air. After this quantity of groundwater has been removed from the well, a sample is taken from a sampling port, after which the groundwater in the expandable container can be returned to the monitoring well through the return system. The purge water management system prevents the purge water from coming in contact with the outside environment, especially oxygen, which might cause the constituents of the groundwater to oxidize. Therefore, by introducing the purge water back into the monitoring well, the necessity of dealing with the purge water as a hazardous waste under the Resource Conservation and Recovery Act is eliminated.

  3. Purge water management system

    DOE Patents [OSTI]

    Cardoso-Neto, J.E.; Williams, D.W.

    1995-01-01

    A purge water management system is described for effectively eliminating the production of purge water when obtaining a groundwater sample from a monitoring well. In its preferred embodiment, the purge water management system comprises an expandable container, a transportation system, and a return system. The purge water management system is connected to a wellhead sampling configuration, typically permanently installed at the well site. A pump, positioned with the monitoring well, pumps groundwater through the transportation system into the expandable container, which expands in direct proportion with volume of groundwater introduced, usually three or four well volumes, yet prevents the groundwater from coming into contact with the oxygen in the air. After this quantity of groundwater has been removed from the well, a sample is taken from a sampling port, after which the groundwater in the expandable container can be returned to the monitoring well through the return system. The purge water management system prevents the purge water from coming in contact with the outside environment, especially oxygen, which might cause the constituents of the groundwater to oxidize. Therefore, by introducing the purge water back into the monitoring well, the necessity of dealing with the purge water as a hazardous waste under the Resource Conservation and Recovery Act is eliminated.

  4. Comprehensive stormwater management study

    SciTech Connect (OSTI)

    Morrison, T. ); Alter, M. ); Wassum, R.H. )

    1994-02-01

    This article examines Tucson, Arizona's approach to stormwater management. The topics of the article include the quantity and quality of stormwater, developing the stormwater master plan, meeting environmental and regulatory constraints. Tucson's comprehensive, watershed by watershed approach to public works planning and stormwater program development is described.

  5. Mobile Technology Management

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2014-05-15

    The order establishes requirements, assigns responsibilities, and provides guidance for federal mobile technology management and employee use of both government furnished and personally-owned mobile devices within DOE and NNSA. Establishes requirements for use of User Agreements to govern mobile devices used for official duties. Does not cancel other directives.

  6. Position Management and Classification

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2015-04-01

    The order establishes departmental requirements and responsibilities for classifying positions using the general schedule (GS) and federal wage system (FWS) standards and to develop and administer a sound position management and classification program. Supersedes DOE O 325.2, dated 4-1-15.

  7. Office of Quality Management

    Energy.gov [DOE]

    The Office of Quality Management develops and interprets Government-wide policies and procedures and conducts training to ensure the accurate identification of information and documents that must be classified or controlled under statute or Executive order to protect the national security and controlled unclassified Official Use Only information for the effective operation of the Government.

  8. Substation asset management study

    SciTech Connect (OSTI)

    Conroy, M.W.; Conidi, J.

    1996-03-01

    This paper will present an overview of our recent findings in the area of substation asset management and will describe how several utilities, in response to the issues listed above, are re-examining their present maintenance practices in search of more cost-effective programs.

  9. Radioactive Waste Management

    Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-07-09

    The objective of this Order is to ensure that all Department of Energy (DOE) radioactive waste is managed in a manner that is protective of worker and public health and safety and the environment. Cancels DOE O 5820.2A

  10. CNS Project Management

    Office of Energy Efficiency and Renewable Energy (EERE)

    The experience with major nuclear design and construction projects continues to highlight the importance of a focused, technically rigorous, and standardized approach to project reviews performed at Critical Decision (CD) approval points. This approach is fundamental to a positive safety culture and effective nuclear safety management.

  11. Risk Assessment & Management Information

    Energy.gov [DOE]

    NRC - A Proposed Risk Management Regulatory Framework, April 2012 Risk Assessment Technical Experts Working Group (RWG) web page DOE Standard on Development and Use of Probabilistic Risk Assessment in DOE Nuclear Safety Applications (draft), December 2010 Consortium for Risk Evaluation with Stakeholder Participation Workshop on Risk Assessment and Safety Decision Making Under Uncertainty

  12. Comprehensive Emergency Management System

    Directives, Delegations, and Requirements [Office of Management (MA)]

    1996-08-21

    The Order establishes policy and assigns and describes roles and responsibilities for the DOE Emergency Management System. Cancels DOE 5500.1B, DOE 5500.2B, DOE 5500.3A, DOE 5500.4A, 5500.5A,5500.7B, 5500.8A, 5500.9A, DOE 5500.10

  13. Comprehensive Emergency Management System

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2003-10-29

    To establish policy and to assign and describe roles and responsibilities for the Department of Energy (DOE) Emergency Management System. (This is an administrative change to DOE O 151.1A). Canceled by DOE O 151.1C. Cancels DOE O 151.1A.

  14. Integrated Safety Management

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Safety Management BEHAVIOR (SAFETY CULTURE) - principles of behavior (values) - align motivations PLAN WORK define project scope define facility functional requirements define and analyze hazards mitigate hazards develop & implement controls authorize work assess & improve work execution reaction to changed conditions LEVELS - INSTITUTIONAL - site wide programs - DOE directives & requirements, cultural values - DOE/contractor interface - FACILITY OR PROJECT - Documented Safety

  15. Comprehensive Environmental Management Process

    SciTech Connect (OSTI)

    Hjeresen, D.L.; Roybal, S.L.

    1994-08-01

    This report contains information about Los Alamos National Laboratory`s Comprehensive Environmental Management Plan. The topics covered include: waste minimization, waste generation, environmental concerns, public relations of the laboratory, and how this plan will help to answer to the demands of the laboratory as their mission changes.

  16. Use of Management and Operating or Other Facility Management...

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    50.2C, Use of Management and Operating or Other Facility Management Contractor Employees for Services to DOE in the Washington, D.C. Area by Andrew Geary Functional areas: Work for...

  17. OFFICE OF ENVIRONMENTAL MANAGEMENT NAMES NEW IDAHO CLEANUP MANAGER

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Energy OFFICE OF ENVIRONMENTAL MANAGEMENT (EM) ORGANIZATION CHART OFFICE OF ENVIRONMENTAL MANAGEMENT (EM) ORGANIZATION CHART OFFICE OF ENVIRONMENTAL MANAGEMENT (EM) ORGANIZATION CHART Download Printable Version Mission & Functions Statement for the Office of Environmental Management

    Tim Jackson (208) 526-8484 For Immediate Release May 29, 2014 Public invited to comment on Draft Environmental Assessment on the Disposition of Five Signature Properties at Idaho National Laboratory The

  18. Best Management Practice #1: Water Management Planning | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energy 1: Water Management Planning Best Management Practice #1: Water Management Planning A successful water management program starts with a comprehensive strategic plan. The process for developing a strategic plan is generally the same for an individual facility or an agency. The plan provides information about current water uses and charts a course for water efficiency improvements, conservation activities, and water-reduction goals. A strategic plan establishes the priorities and helps

  19. Managing our water resources

    SciTech Connect (OSTI)

    Not Available

    1982-05-01

    Water is a plentiful, renewable resource if it is properly managed. The US allocates 82% of its water to agriculture, 10% to industries and utilities. American farmers are beginning to adopt water-conserving techniques long used in the world's arid regions because past profligate use and recent droughts lowered both water tables and farm productivity. Runoff and pollution are responsible for much of the waste of usable water. Because of local water shortages, there is interest in drip irrigation, setting aside more land for reservoirs, and other conservation techniques to ensure adequate supplies for industrial development and economic growth. American faith in technology has led to schemes for desalination, cloud seeding, iceberg towing, and aquifer recharging, as well as the existing system of dams. Proper management of river basins is an important step in the process. 1 figure. (DCK)

  20. Organic Matter Management

    SciTech Connect (OSTI)

    Izaurralde, Roberto C.; Cerri, Carlos C.

    2002-01-01

    Soil organic matter (S)M) is an essential attribute of soil quality with a key role in soil conservation and sustainable agriculture. Many practices-some involving land use changes-have been shown to increase SOM and thus received considerable attention for their possible role in climate change mitigation. Carbon sequestration in managed soils occurs when there is a net removal of atmospheric CO2 because of the balance between carbon inputs (net primary productivity) and outputs (soil respiration, management-related C emissions). Soil C sequestration has the additional appeal that all its practices conform to principles of sustainable agriculture (e.g., reduced tillage, erosion control, diverse cropping systems, improved soil fertility). Long-term field experiments have been instrumental to increase our understanding of SOM dynamics. This chapter presents fundamental concepts to guide readers on the role of SOM in sustainable agriculture and climate change mitigation.

  1. Jefferson Lab Emergency Management

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    EH&S EH&S Home Contacts ES&H Manual print version GROUPS ES&H Committees Emergency Management Environmental Programs Occupational Medicine Quality Assurance & Continuous Improvement Radiation Control Health & Safety Programs Associate Director's Office LINKS Safety Observations Safety Concern Form Safety Warden Info. ES&H Contacts ESH&Q Document Review Database Key Links Resources JLab Lessons Learned Corrective Actions Tracking System (CATS) Safety Warden

  2. Federal Water Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Water Cycle Potable water: water of sufficient quality for human consumption Industrial landscaping and agricultural (ILA) water: non-potable water from fresh surface or groundwater Alternative water: onsite non- potable water NOT supplied from fresh surface or groundwater Rainwater Reclaimed wastewater Process reuse Graywater Condensate Set goals Assess current water use Develop a water balance Evaluate efficiency Develop a plan Measure progress Water Management Planning Supply Uses Plumbing

  3. Management Control Cover

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    the Hanford Site Transuranic Mixed Tank Waste OAS-M-06-01 November 2005 REPORT ON MANAGEMENT CONTROLS OVER THE HANFORD SITE TRANSURANIC MIXED TANK WASTE TABLE OF CONTENTS Hanford Site Transuranic Mixed Tank Waste Details of Finding 1 Recommendations and Comments 3 Appendices Objective, Scope, and Methodology 6 Prior Audit Reports 8 Hanford Site Transuranaic Mixed Tank Waste Page 1 Details of Finding Regulation and The Office of River Protection (ORP) pursued the Transuranic Permits Mixed Tank

  4. Records Management Exit Procedures

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Records Management Exit Procedures For Departing Federal and contractor Employees PRESERVATION OF FEDERAL RECORDS The Federal Records Act requires the Department of Energy (DOE) Records Officer to remind departing Federal and contractor employees that Federal records may not be removed from Government custody nor may they be destroyed except in accordance with a records disposition schedule that has been approved by the Archivist of the United States. The creation of adequate documentation and

  5. Enterprise Risk Management Framework

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Framework The Enterprise Risk Management (ERM) framework includes four steps: identify the risks, determine the probability and impact of each one, identify controls that are already in place that mitigate that risk, and propose additional controls if needed. Step 1: Identify Risks - What can go wrong? This step should identify the negative outcomes that could result from an action or decision . It is important to consider a wide range of risks, and so the Department's ERM framework includes

  6. Enterprise Risk Management Model

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Model The Enterprise Risk Management (ERM) Model is a system used to analyze the cost and benefit of addressing risks inherent in the work performed by the Department of Energy. This system measures risk using a combination of qualitative and quantitative methods to set a standard method for analyzing risk across the many functions within the department. Risks generally fall within five categories regardless ofthe subject matter ofthe subsystem. These categories are (1) risks to people, (2)

  7. Conditional data watchpoint management

    DOE Patents [OSTI]

    Burdick, Dean Joseph; Vaidyanathan, Basu

    2010-08-24

    A method, system and computer program product for managing a conditional data watchpoint in a set of instructions being traced is shown in accordance with illustrative embodiments. In one particular embodiment, the method comprises initializing a conditional data watchpoint and determining the watchpoint has been encountered. Upon that determination, examining a current instruction context associated with the encountered watchpoint prior to completion of the current instruction execution, further determining a first action responsive to a positive context examination; otherwise, determining a second action.

  8. Chemical Management System

    Energy Science and Technology Software Center (OSTI)

    1998-10-30

    CMS provides an inventory of all chemicals on order or being held in the laboratory, to provide a specific location for all chemical containers, to ensure that health and safety regulatory codes are being upheld, and to provide PNNL staff with hazardous chemical information to better manage their inventories. CMS is comprised of five major modules: 1) chemical purchasing, 2) chemical inventory, 3) chemical names, properties, and hazard groups, 4) reporting, and 5) system administration.

  9. Emergency Management System

    Directives, Delegations, and Requirements [Office of Management (MA)]

    1995-09-25

    The order establishes policy, and assigns and describes roles and responsibilities for the DOE Emergency Management System. DOE 5500.1B Chg 1; DOE 5500.2B Chg 1; DOE 5500.3A Chg 1; DOE 5500.4A; DOE 5500.5A; DOE 5500.7B; DOE 5500.8A; DOE 5500.9A, and DOE 5500.10A Chg 1. Canceled by DOE O 151.1A.

  10. Industrial Carbon Management Initiative

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Industrial Assessment Centers Update, Fall 2015 Industrial Assessment Centers Update, Fall 2015 Read the Industrial Assessment Centers (IAC) Update, Fall 2015 Industrial Assessment Centers Update, Fall 2015 (477.91 KB) More Documents & Publications Industrial Assessment Centers (IAC) Update -- July 2015 Industrial Assessment Centers Update, Spring 2016 Industrial Assessment Centers Quarterly Update, Spring 2014

    Industrial Carbon Management Initiative Fact Sheets Research Team Members Key

  11. BETO Project Management Review

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Program Management Review June 25, 2015 Jonathan Male Director, Bioenergy Technologies Office (BETO) 2 | Bioenergy Technologies Office I. BETO Portfolio II. Coordination of Technology Areas III. Synergies IV. Project Impacts V. Technology Pathways VI. Budget Priorities VII. Other Technologies & Market Trends VIII. New Initiatives Outline 3 | Bioenergy Technologies Office BETO Portfolio * Integration of lessons learned for IBRs - BETO's IBR Investment Report has been finalized and will be

  12. Baxter … Account Management

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Design the Strategy | Deliver Efficiency | Sustain Results ISO 50001/SEP Superior Energy Performance at Schneider Electric Schneider Electric - Sustainability Services - 2014 2 Schneider Electric - the global specialist in energy management billion € sales (last twelve months) of sales in new economies (last twelve months) people in 100+ countries of sales devoted to R&D Residential 9% Utilities & Infrastructure 24% Industrial & machines 22% Data centres 16% Non-residential

  13. ENERGY STAR Portfolio Manager 201

    Energy.gov [DOE]

    Continue to learn about EPA’s new ENERGY STAR Portfolio Manager tool, with a deeper dive into more advanced functionalities such as: managing and tracking changes to your property uses over time;...

  14. Fleet Managment Catalog of Services

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Fleet Management Catalog of Services The U.S. Department of Energy Federal Energy Management Program September 2016 Table of Contents Contents Contents ........................................................................................................................................................ i Executive Summary ..................................................................................................................................... i Planning Phase

  15. Project Management Career Development Program

    Office of Energy Efficiency and Renewable Energy (EERE)

    The Project Management Career Development Program (PMCDP) in Office of Project Management Oversight and Assessments was established in 2001 by a Congressional mandate to ensure the Department of...

  16. Environmental Management (EM) Cleanup Projects

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2008-09-24

    The guide supports DOE O 413.3A, Program and Project Management for the Acquisition of Capital Assets, and provides guidance on environmental management cleanup projects. Canceled by DOE N 251.105.

  17. Departmental Cyber Security Management Policy

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2001-05-08

    The Departmental Cyber Security Management (DCSM) Policy was developed to further clarify and support the elements of the Integrated Safeguards and Security Management (ISSM) Policy regarding cyber security. Certified 9-23-10. No cancellation.

  18. ENERGY STAR Portfolio Manager 101

    Energy.gov [DOE]

    Join us as we introduce and demonstrate the core functionality of EPA’s ENERGY STAR Portfolio Manager tool. Attendees will learn how to: navigate Portfolio Manager; add a property and enter details...

  19. Contractor Human Resource Management Programs

    Directives, Delegations, and Requirements [Office of Management (MA)]

    1996-09-30

    The purpose of this directive is to establish Department of Energy (DOE) responsibilities and requirements for the management and oversight of contractor Human Resource Management (HR) programs. Chg 1, 5-8-98; Chg 2, 11-22-09.

  20. Earned Value Management System (EVMS)

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2008-05-06

    The Guide supports the Departments initiatives to improve program, project, and contract management through the implementation and surveillance of contractors earned value management systems. Canceled by DOE G 413.3-10A.

  1. Contractor Human Resource Management Programs

    Directives, Delegations, and Requirements [Office of Management (MA)]

    1996-09-30

    The purpose of this directive is to establish Department of Energy (DOE) responsibilities and requirements for the management and oversight of contractor Human Resource Management (HR) programs. Chg 1, 5-8-98; Chg 2, 11-22-09

  2. NERSC Information Management (NIM) portal

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    The NERSC Information Management (NIM) system is a web portal used to view and modify user ... The NERSC Information Management (NIM) system is a web portal used to view and modify user ...

  3. Environmental management activities

    SciTech Connect (OSTI)

    1997-07-01

    The Office of Environmental Management (EM) has been delegated the responsibility for the Department of Energy`s (DOE`s) cleanup of the nuclear weapons complex. The nature and magnitude of the waste management and environmental remediation problem requires the identification of technologies and scientific expertise from domestic and foreign sources. Within the United States, operational DOE facilities, as well as the decontamination and decommissioning of inactive facilities, have produced significant amounts of radioactive, hazardous, and mixed wastes. In order to ensure worker safety and the protection of the public, DOE must: (1) assess, remediate, and monitor sites and facilities; (2) store, treat, and dispose of wastes from past and current operations; and (3) develop and implement innovative technologies for environmental restoration and waste management. The EM directive necessitates looking beyond domestic capabilities to technological solutions found outside US borders. Following the collapse of the Soviet regime, formerly restricted elite Soviet scientific expertise became available to the West. EM has established a cooperative technology development program with Russian scientific institutes that meets domestic cleanup objectives by: (1) identifying and accessing Russian EM-related technologies, thereby leveraging investments and providing cost-savings; (2) improving access to technical information, scientific expertise, and technologies applicable to EM needs; and (3) increasing US private sector opportunities in Russian in EM-related areas.

  4. Accident management information needs

    SciTech Connect (OSTI)

    Hanson, D.J.; Ward, L.W.; Nelson, W.R.; Meyer, O.R. (EG and G Idaho, Inc., Idaho Falls, ID (USA))

    1990-04-01

    In support of the US Nuclear Regulatory Commission (NRC) Accident Management Research Program, a methodology has been developed for identifying the plant information needs necessary for personnel involved in the management of an accident to diagnose that an accident is in progress, select and implement strategies to prevent or mitigate the accident, and monitor the effectiveness of these strategies. This report describes the methodology and presents an application of this methodology to a Pressurized Water Reactor (PWR) with a large dry containment. A risk-important severe accident sequence for a PWR is used to examine the capability of the existing measurements to supply the necessary information. The method includes an assessment of the effects of the sequence on the measurement availability including the effects of environmental conditions. The information needs and capabilities identified using this approach are also intended to form the basis for more comprehensive information needs assessment performed during the analyses and development of specific strategies for use in accident management prevention and mitigation. 3 refs., 16 figs., 7 tabs.

  5. Life Cycle Asset Management

    Directives, Delegations, and Requirements [Office of Management (MA)]

    1998-10-14

    (The following directives are deleted or consolidated into this Order and shall be phased out as noted in Paragraph 2: DOE 1332.1A; DOE 4010.1A; DOE 4300.1C; DOE 4320.1B; DOE 4320.2A; DOE 4330.4B; DOE 4330.5; DOE 4540.1C; DOE 4700.1). This Order supersedes specific project management provisions within DOE O 430.1A, LIFE CYCLE ASSET MANAGEMENT. The specific paragraphs canceled by this Order are 6e(7); 7a(3); 7b(11) and (14); 7c(4),(6),(7),(11), and (16); 7d(4) and (8); 7e(3),(10), and (17); Attachment 1, Definitions (item 30 - Line Item Project, item 42 - Project, item 48 - Strategic System); and Attachment 2, Contractor Requirements Document (paragraph 1d regarding a project management system). The remainder of DOE O 430.1A remains in effect. Cancels DOE O 430.1. Canceled by DOE O 413.3.

  6. LEGACY MANAGEMENT REQUIRES INFORMATION

    SciTech Connect (OSTI)

    CONNELL, C.W.; HILDEBRAND, R.D.

    2006-12-14

    ''Legacy Management Requires Information'' describes the goal(s) of the US Department of Energy's Office of Legacy Management (LM) relative to maintaining critical records and the way those goals are being addressed at Hanford. The paper discusses the current practices for document control, as well as the use of modern databases for both storing and accessing the data to support cleanup decisions. In addition to the information goals of LM, the Hanford Federal Facility Agreement and Consent Order, known as the ''Tri-Party Agreement'' (TPA) is one of the main drivers in documentation and data management. The TPA, which specifies discrete milestones for cleaning up the Hanford Site, is a legally binding agreement among the US Department of Energy (DOE), the Washington State Department of Ecology (Ecology), and the US Environmental Protection Agency (EPA). The TPA requires that DOE provide the lead regulatory agency with the results of analytical laboratory and non-laboratory tests/readings to help guide them in making decisions. The Agreement also calls for each signatory to preserve--for at least ten years after the Agreement has ended--all of the records in its or its contractors, possession related to sampling, analysis, investigations, and monitoring conducted. The tools used at Hanford to meet TPA requirements are also the tools that can satisfy the needs of LM.

  7. Corporate information management guidance

    SciTech Connect (OSTI)

    1997-08-01

    At the request of the Department of Energy`s (DOE) Information Management (IM) Council, IM representatives from nearly all Headquarters (HQ) organizations have been meeting over the past year as the Corporate Guidance Group (CGG) to develop useful and sound corporate information management (IM) guidance. The ability of the Department`s IM community to develop such unified guidance continues to be critical to the success of future Departmental IM planning processes and the establishment of a well-coordinated IM environment between Headquarters and field organizations. This report, with 26 specific corporate IM guidance items documented and unanimously agreed to, as well as 12 items recommended for further development and 3 items deferred for future consideration, represents a highly successful effort by the IM community. The effort has proven that the diverse DOE organizations can put aside individual preferences and work together towards a common and mutually beneficial goal. In examining most areas and issues associated with information management in the Department, they have developed specific, far-reaching, and useful guidance. The IM representatives recommend that the documented guidance items provided in this report and approved by the DOE IM Council be followed by all IM organizations. The representatives also strongly recommend that the guidance process developed by the CGG be the single process for developing corporate IM guidance.

  8. Management & Administration | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Management & Administration Management & Administration Management & Administration The Office of Management and Administration directs the development, coordination, and execution of overall OIG management and administrative policy and planning. This responsibility includes directing the OIG's strategic planning process, financial management activities, personnel management and security programs, administrative support services, and information resources programs. In addition, the

  9. PORTFOLIO MANAGEMENT | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    PORTFOLIO MANAGEMENT PORTFOLIO MANAGEMENT PORTFOLIO MANAGEMENT Once LPO closes a loan or loan guarantee, projects are monitored and evaluated throughout project development, construction, commissioning, and operation until the loan has been repaid in full. LPO's team of financial, technical, environmental, and legal professionals is dedicated to advancing an all-of-the-above energy strategy that avoids, reduces, or sequesters greenhouse gases. PORTFOLIO MANAGEMENT DIVISION (PMD) After financial

  10. Quality assurance and data management

    SciTech Connect (OSTI)

    Lockrem, L.L.

    1998-01-12

    This report contains graphs and tables relating to quality assurance and data management for environmental quality at Hanford Reservation.

  11. Project Management Improvements Drive Progress

    Energy.gov [DOE]

    WASHINGTON, D.C. – Improving project management has been a top priority of EM’s senior leadership.

  12. Managing Financing Programs- Spreadsheet Models

    Energy.gov [DOE]

    This webinar, held on Jan. 24, 2011, provides a tutorial for managing financing programs through excel spreadsheets.

  13. Categorical Exclusion Determinations: Environmental Management...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Consolidated Business Service Center Categorical Exclusion Determinations: Environmental Management Consolidated Business Service Center Categorical Exclusion Determinations issued ...

  14. LTS Project Management - Hanford Site

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    ... Key Communication Tools Briefings Fact sheets Website Public documents Frequently Asked ... Laser Interferometer Gravitational Wave Observatory Information Management ...

  15. NIF & Photon Science Management

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    management NIF & Photon Science Management The management team for the NIF & Photon Science Principal Directorate supports the directorate's key mission areas: Stockpile Stewardship, national security applications, NIF Discovery Science, laser-based directed energy and related laser and optical technologies, and advanced photon technologies. Directorate Programs Jeff Wisoff Principal Associate Director NIF & Photon Science Jeff Atherton Principal Deputy Principal Associate Director

  16. Office of Management and Budget | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    Office of Management and Budget

  17. Guide to Scientific Management | Argonne National Laboratory

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Guide to Scientific Management A Practical Guide to Scientifıc Management for Postdocs and New Faculty. PDF icon Guide to Scientific Management second edition.pdf

  18. Office of Project Management Oversight & Assessments | Department...

    Energy.gov (indexed) [DOE]

    Office of Project Management Oversight & Assessments Career Development Project Management Career Development Program (DOE Only) Acquisition Career Management Program (DOE Only)...

  19. Ethanol Capital Management | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Management Jump to: navigation, search Name: Ethanol Capital Management Place: Tucson, Arizona Zip: 85711 Product: Manages funds investing in Ethanol plants in the US Coordinates:...

  20. Solar International Management Inc | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    International Management Inc Jump to: navigation, search Name: Solar International Management Inc Place: Washington,DC, Washington, DC Zip: 20006 Sector: Solar Product: Manager of...

  1. GHG Management Institute | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    GHG Management Institute Jump to: navigation, search Name: GHG Management Institute Address: Greenhouse Gas Management Institute 9215 View Avenue NW Seattle, WA USA 98117 Place:...

  2. Interagency Energy Management Task Force Members

    Energy.gov [DOE]

    The Interagency Energy Management Task Force is led by the Federal Energy Management Program director. Members include energy and sustainability managers from federal agencies.

  3. Generation Investment Management LLP | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Investment Management LLP Jump to: navigation, search Name: Generation Investment Management LLP Place: London, Greater London, United Kingdom Zip: W1J 0AH Product: Fund manager of...

  4. PPPO Program Management | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Management PPPO Program Management PPPO provides program and operations management for the cleanup of the former gaseous diffusion plant sites at Portsmouth, Ohio and Paducah, ...

  5. Paducah Site Management Plan | Department of Energy

    Energy Savers

    Management Plan Paducah Site Management Plan The annual Paducah Gaseous Diffusion Plant Site Management Plan (SMP) outlines DOE's strategic approach for achieving cleanup under the ...

  6. Data Management Facility Operations Plan (Program Document) ...

    Office of Scientific and Technical Information (OSTI)

    Program Document: Data Management Facility Operations Plan Citation Details In-Document Search Title: Data Management Facility Operations Plan The Data Management Facility (DMF) is ...

  7. EERE Digital Data Management | Department of Energy

    Office of Environmental Management (EM)

    EERE Digital Data Management EERE Digital Data Management The Office of Energy Efficiency and Renewable Energy (EERE) Policy on Digital Data Management is part of the ...

  8. Project Management Information Systems (PMIS) | Department of...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Project Management Information Systems (PMIS) Project Management Information Systems (PMIS) Project Assessment & Reporting System (PARS IIe) Office of Project Management Oversight...

  9. Records Management Handbook | Department of Energy

    Energy.gov (indexed) [DOE]

    Records Management Handbook (628.31 KB) More Documents & Publications Records Management Handbook PROCEDURE FOR CONDUCTING A RECORDS INVENTORY Information and Records Management ...

  10. Green Capital Management | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Capital Management Jump to: navigation, search Name: Green Capital Management Place: London, United Kingdom Zip: SW10 0BB Sector: Services Product: The Green Capital Management...

  11. Federal Energy Management Program Report Template | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Federal Energy Management Program Report Template Federal Energy Management Program Report Template Template to create reports for the Federal Energy Management Program (FEMP)...

  12. Change Control Management Guide - DOE Directives, Delegations...

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    20, Change Control Management Guide by Ruben Sanchez Functional areas: Program Management, Project Management The Guide provides a suggested approach and uniform guidance for...

  13. Information Management Governance Council | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Management Governance Council Information Management Governance Council Describes the establishment of the Information Management Governance Council and What They Do. PDF icon...

  14. Project Management Plans | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Management Plans Project Management Plans The purpose here is to assist project managers and project planners in creating a project plan by providing examples and pointing to ...

  15. Project Management Perspective - Paul Bosco, Director, Office...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Project Management Perspective - Paul Bosco, Director, Office of Acquisition and Project Management Project Management Perspective - Paul Bosco, Director, Office of Acquisition and ...

  16. Fermilab | Directorate | Office of Project Management Oversight...

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Office of Project Management Oversight Fermilab ManagementNon-Scientific Projects Current Management Projects IARC OTE Building Liquid Argon Test Building (LArTB) TeV ...

  17. IT Project Management Profile | Department of Energy

    Energy Savers

    Project Management Profile IT Project Management Profile This form lists positionsexperience and training relating to project management; include other positionsexperience or ...

  18. IT Project Management Profile | Department of Energy

    Energy Savers

    Project Management Profile IT Project Management Profile This is a form that must be completed to initiate the assessment of a Project Manager to determine the level of ...

  19. Project Management Plan Examples | Department of Energy

    Office of Environmental Management (EM)

    Examples Project Management Plan Examples Examples From Project Management Plans The following material has been extracted from several project management plans. The order in which ...

  20. TPA Project Manager's Lists - Hanford Site

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    TPA Project Manager's Lists Tri-Party Agreement The Agreement Announcements List of Approved Changes TPA Project Manager's Lists Modifications for Public Comment Data Management...

  1. DOE - Office of Legacy Management -- GJO

    Office of Legacy Management (LM)

    (D&D) Program, the Office of Legacy Management manages the Grand Junction ... The site transferred to the Office of Legacy Management in 2003 and requires routine ...

  2. DOE - Office of Legacy Management -- Piqua

    Office of Legacy Management (LM)

    (D&D) Program, the Office of Legacy Management manages the Piqua ... The site transferred to the Office of Legacy Management in 2003 and requires routine ...

  3. DOE - Office of Legacy Management -- GJD

    Office of Legacy Management (LM)

    Responsibility for custody and long-term management of the site transferred to DOE's Office of Legacy Management in 2003. Management responsibilities include routine inspection and ...

  4. DOE - Office of Legacy Management -- Hallam

    Office of Legacy Management (LM)

    (D&D) Program, the Office of Legacy Management manages the Hallam ... The site transferred to the Office of Legacy Management in 2003 and requires routine ...

  5. DOE - Office of Legacy Management -- GJP

    Office of Legacy Management (LM)

    Responsibility for management and long-term custody of the site's contaminated groundwater transferred to DOE's Office of Legacy Management in 2003. Management requirements include ...

  6. 2015 Program Management Review Presentations | Department of...

    Office of Environmental Management (EM)

    Program Management Review Presentations 2015 Program Management Review Presentations The Bioenergy Technologies Office's (BETO) 2015 Program Management Review was held on June 25, ...

  7. Environmental Management System Plan

    SciTech Connect (OSTI)

    Fox, Robert; Thorson, Patrick; Horst, Blair; Speros, John; Rothermich, Nancy; Hatayama, Howard

    2009-03-24

    Executive Order 13423, Strengthening Federal Environmental, Energy, and Transportation Management establishes the policy that Federal agencies conduct their environmental, transportation, and energy-related activities in a manner that is environmentally, economically and fiscally sound, integrated, continually improving, efficient, and sustainable. The Department of Energy (DOE) has approved DOE Order 450.1A, Environmental Protection Program and DOE Order 430.2B, Departmental Energy, Renewable Energy and Transportation Management as the means of achieving the provisions of this Executive Order. DOE Order 450.1A mandates the development of Environmental Management Systems (EMS) to implement sustainable environmental stewardship practices that: (1) Protect the air, water, land, and other natural and cultural resources potentially impacted by facility operations; (2) Meet or exceed applicable environmental, public health, and resource protection laws and regulations; and (3) Implement cost-effective business practices. In addition, the DOE Order 450.1A mandates that the EMS must be integrated with a facility's Integrated Safety Management System (ISMS) established pursuant to DOE P 450.4, 'Safety Management System Policy'. DOE Order 430.2B mandates an energy management program that considers energy use and renewable energy, water, new and renovated buildings, and vehicle fleet activities. The Order incorporates the provisions of the Energy Policy Act of 2005 and Energy Independence and Security Act of 2007. The Order also includes the DOE's Transformational Energy Action Management initiative, which assures compliance is achieved through an Executable Plan that is prepared and updated annually by Lawrence Berkeley National Laboratory (LBNL, Berkeley Lab, or the Laboratory) and then approved by the DOE Berkeley Site Office. At the time of this revision to the EMS plan, the 'FY2009 LBNL Sustainability Executable Plan' represented the most current Executable Plan. These

  8. Earned Value Management System (EVMS)

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2012-03-13

    To support DOE's initiatives to improve program, project, and contract management through the implementation and surveillance of a contractor's Earned Value Management System (EVMS) that is in conformance with DOE O 413.3B, Program and Project Management for the Acquisition of Capital Assets, the American National Standards Institute/Electronic Industries Alliance (ANSI/EIA)-748-B, Earned Value Management System (or as required by contract), and Federal Acquisition Regulation (FAR) 52.234-4, Earned Value Management System (EVMS). Admin Chg 1 dated 10-22-2015.

  9. Operational Management | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Operational Management Operational Management Operational Management Leadership Contact Information Office of Resource Management and Planning U.S. Department of Energy, MA-1.1 1000 Independence Ave., SW Washington, DC 20585 Marilyn L. Dillon Director marilyn.dillon@hq.doe.gov 202-586-4919 Sustainability Performance Office U.S. Department of Energy, MA-20 1000 Independence Ave., SW Washington, DC 20585 John Shonder Director john.shonder@hq.doe.gov 202-586-8645 Office of Aviation Management U.S.

  10. SUSTAINABILITY SUPERSTAR Environmental Management's

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Environmental Management's Donna Green is retiring! Donna began her DOE career at Argonne National Lab in 1998 before moving to EM in 2008 and quickly assuming the lead on their Sustainability program. She has led the charge to integrate sustainable practices into all aspects of the EM mission, and is one of the 2012 DOE Sustainability Award winners for that effort. We wish her well in her new endeavors! Send us your champion! SUSTAINABILITY NEWS 11 DOE Sites Win Awards in EPA 2012 Federal

  11. Plutonium Vulnerability Management Plan

    SciTech Connect (OSTI)

    1995-03-01

    This Plutonium Vulnerability Management Plan describes the Department of Energy`s response to the vulnerabilities identified in the Plutonium Working Group Report which are a result of the cessation of nuclear weapons production. The responses contained in this document are only part of an overall, coordinated approach designed to enable the Department to accelerate conversion of all nuclear materials, including plutonium, to forms suitable for safe, interim storage. The overall actions being taken are discussed in detail in the Department`s Implementation Plan in response to the Defense Nuclear Facilities Safety Board (DNFSB) Recommendation 94-1. This is included as Attachment B.

  12. Eastern European risk management

    SciTech Connect (OSTI)

    Honey, J.A. )

    1992-01-01

    Here the authors assess Eastern European risk management practices through the evaluation of the nuclear power plants in the region. This evaluation is limited to the Soviet-designed and -built VVER-440 pressurized water reactors (PWRs) that are currently operating in Bulgaria, Czechoslovakia, Hungary, Russia, and the Ukraine and until recently operated at Greifswald in the former East Germany. This evaluation is based on the basic design of the plants, a safety evaluation of the Greifswald facility by representatives from the Federal Republic of Germany and personal visits by the author to Greifswald and Loviisa.

  13. Real Property Asset Management

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2003-09-24

    The directive establishes an integrated corporate-level, performance based approach to the life-cycle management of our real property assets. It links real property asset planning, programming, budgeting and evaluation to the Department's multi-faceted missions. Successful implementation of this order will enable the Department to carry out our stewardship responsibilities, and will ensure that our facilities and infrastructure are properly sized and in a condition to meet our mission requirements today and in the future. Chg 1, dated 2-8-08. Chg 2, dated 4-25-11

  14. Real Property Asset Management

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2003-09-24

    The directive establishes an integrated corporate-level, performance based approach to the life-cycle management of our real property assets. It links real property asset planning, programming, budgeting and evaluation to the Department's multi-faceted missions. Successful implementation of this order will enable the Department to carry out our stewardship responsibilities, and will ensure that our facilities and infrastructure are properly sized and in a condition to meet our mission requirements today and in the future. Cancels: DOE O 430.1A. Chg 1, dated 2-8-08. Chg 2, dated 4-25-11

  15. Real Property Asset Management

    Directives, Delegations, and Requirements [Office of Management (MA)]

    2016-08-19

    The directive establishes an integrated corporate-level, performance based approach to the life-cycle management of our real property assets. It links real property asset planning, programming, budgeting and evaluation to the Department's multi-faceted missions. Successful implementation of this order will enable the Department to carry out stewardship responsibilities, and will ensure that facilities and infrastructure are properly sized and in a condition to meet our mission requirements today and in the future. Supersedes DOE O 430.1B Chg 2.

  16. Information Management Program

    Directives, Delegations, and Requirements [Office of Management (MA)]

    1996-09-30

    Provides a framework for managing information, information resources, and information technology investment, which supports the operating elements of the Department in the accomplishment of its missions and functions in both an efficient and effective manner and in accordance with Departmental policy. Cancels: DOE 1324.5B, DOE 5900.1A, DOE 1130.8A, DOE 1330.1D, DOE 1410.2, DOE 1450.3A, DOE 1700.1, DOE 1800.1A, DOE 5300.1C

  17. Depleted uranium management alternatives

    SciTech Connect (OSTI)

    Hertzler, T.J.; Nishimoto, D.D.

    1994-08-01

    This report evaluates two management alternatives for Department of Energy depleted uranium: continued storage as uranium hexafluoride, and conversion to uranium metal and fabrication to shielding for spent nuclear fuel containers. The results will be used to compare the costs with other alternatives, such as disposal. Cost estimates for the continued storage alternative are based on a life-cycle of 27 years through the year 2020. Cost estimates for the recycle alternative are based on existing conversion process costs and Capital costs for fabricating the containers. Additionally, the recycle alternative accounts for costs associated with intermediate product resale and secondary waste disposal for materials generated during the conversion process.

  18. Measuring Process Safety Management

    SciTech Connect (OSTI)

    Sweeney, J.C. (ARCO Chemical Co., Newtown Square, PA (United States))

    1992-04-01

    Many companies are developing and implementing Process Safety Management (PSM) systems. Various PSM models, including those by the Center for Chemical Process Safety (CCPS), the American Petroleum Institute (API), the Chemical Manufacturers Association (CMA) and OSHA have emerged to guide the design, development and installation of these systems. These models represent distillations of the practices, methods and procedures successfully used by those who believed that a strong correlation exists between sound PSM practices and achieving reductions in the frequency and severity of process incidents. This paper describes the progress of CCPS research toward developing a PSM performance measurement model. It also provides a vision for future CCPS research to define effectiveness indices.

  19. Power management system

    DOE Patents [OSTI]

    Algrain, Marcelo C.; Johnson, Kris W.; Akasam, Sivaprasad; Hoff, Brian D.

    2007-10-02

    A method of managing power resources for an electrical system of a vehicle may include identifying enabled power sources from among a plurality of power sources in electrical communication with the electrical system and calculating a threshold power value for the enabled power sources. A total power load placed on the electrical system by one or more power consumers may be measured. If the total power load exceeds the threshold power value, then a determination may be made as to whether one or more additional power sources is available from among the plurality of power sources. At least one of the one or more additional power sources may be enabled, if available.

  20. CURTKOEGEN Business Manager

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Union of Operating Engineers/Local 370 Affiliated with P.O. Box 3386 510 SOUTH ELM SPOKANE, WA 99220 (509) 624-~670 FAX (509) 624-5554 AFL-CIO ;risdiction *pstern Woshmgton ;rid CURTKOEGEN Business Manager tate ofldoho <~ .. ,*. ': . 64 ~AVl:JIMIU. P!i1t'Hl'iN December l l ~ 2015 Joyce N. Gilbert U.S. Department of Energy Richland Operations Office P.O. Box 550 MSlN A7-27 Richland, WA99352 Freedom of Information Act Request RE: United Rentals at Hanford This is a formal letter of request for

  1. AVLIS production plant waste management plan

    SciTech Connect (OSTI)

    Not Available

    1984-11-15

    Following the executive summary, this document contains the following: (1) waste management facilities design objectives; (2) AVLIS production plant wastes; (3) waste management design criteria; (4) waste management plan description; and (5) waste management plan implementation. 17 figures, 18 tables.

  2. (Managing the global environment)

    SciTech Connect (OSTI)

    Rayner, S.F.

    1989-10-03

    The conference was stimulated by concern that policy makers increasingly have to make environmental management decisions in the absence of solidly established scientific consensus about ecological processes and the consequences of human actions. Often, as in the case of climate change, some decisions may have to be made in the absence of information that is desirable but may not be available for years to come, if ever. Six topics were identified as running throughout the Congress. These were: the epistemology and history of the sciences or disciplines concerned with the environment, including the scientific basis of rationality and modes of dealing with uncertainty and complexity; the social, economic, and institutional conditions for the production of knowledge bearing on the environment, including the politics of research and the improvement of scientific data; the structuring and institutionalization of expert assessments on national and international levels, including the global distribution of expertise; the means of establishing scientific information, the role of the media in transmitting and processing knowledge about the environment, and the organization of public environmental debate; and decision making and management under conditions of uncertainty; and, finally the relationship between science and ethics. 13 refs.

  3. ISSUES MANAGEMENT PROGRAM MANUAL

    SciTech Connect (OSTI)

    Gravois, Melanie

    2007-06-27

    The Lawrence Berkeley National Laboratory (LBNL) Issues Management Program encompasses the continuous monitoring of work programs, performance and safety to promptly identify issues to determine their risk and significance, their causes, and to identify and effectively implement corrective actions to ensure successful resolution and prevent the same or similar problems from occurring. This document describes the LBNL Issues Management Program and prescribes the process for issues identification, tracking, resolution, closure, validation, and effectiveness of corrective actions. Issues that are governed by this program include program and performance deficiencies or nonconformances that may be identified through employee discovery, internal or external oversight assessment findings, suggested process improvements and associated actions that require formal corrective action. Issues may also be identified in and/or may result in Root Cause Analysis (RCA) reports, Price Anderson Amendment Act (PAAA) reports, Occurrence Reporting and Processing System (ORPS) reports, Accident Investigation reports, assessment reports, and External Oversight reports. The scope of these issues may include issues of both high and low significance as well as adverse conditions that meet the reporting requirements of the University of California (UC) Assurance Plan for LBNL or other reporting entities (e.g., U.S. Environmental Protection Agency, U.S. Department of Energy). Issues that are found as a result of a walk-around or workspace inspection that can be immediately corrected or fixed are exempt from the requirements of this document.

  4. Cryptographic Key Management System

    SciTech Connect (OSTI)

    No, author

    2014-02-21

    This report summarizes the outcome of U.S. Department of Energy (DOE) contract DE-OE0000543, requesting the design of a Cryptographic Key Management System (CKMS) for the secure management of cryptographic keys for the energy sector infrastructure. Prime contractor Sypris Electronics, in collaboration with Oak Ridge National Laboratories (ORNL), Electric Power Research Institute (EPRI), Valicore Technologies, and Purdue University's Center for Education and Research in Information Assurance and Security (CERIAS) and Smart Meter Integration Laboratory (SMIL), has designed, developed and evaluated the CKMS solution. We provide an overview of the project in Section 3, review the core contributions of all contractors in Section 4, and discuss bene ts to the DOE in Section 5. In Section 6 we describe the technical construction of the CKMS solution, and review its key contributions in Section 6.9. Section 7 describes the evaluation and demonstration of the CKMS solution in different environments. We summarize the key project objectives in Section 8, list publications resulting from the project in Section 9, and conclude with a discussion on commercialization in Section 10 and future work in Section 11.

  5. EERE Program Management Initiative (PMI) Brochure

    Energy.gov [DOE]

    The EERE Program Management Initiative document outlines a coordinated set of actions to improve its program management capabilities.

  6. Configuration management plan for LABCORE Program

    SciTech Connect (OSTI)

    Rich, H.S.

    1995-01-03

    A hardware/software configuration management plan for LABCORE. LABCORE is a laboratory information management system used by Analytical Services.

  7. Material Management and Minimization | National Nuclear Security...

    National Nuclear Security Administration (NNSA)

    Management and Minimization | National Nuclear Security Administration Facebook Twitter Youtube Flickr RSS People Mission Managing the Stockpile Preventing Proliferation Powering...

  8. Environmental Management Associates | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Environmental Management Associates (Redirected from EMA Associates) Jump to: navigation, search Name: Environmental Management Associates Abbreviation: EMA Website:...

  9. EM Hosts Contract Performance and Management Workshop

    Energy.gov [DOE]

    WASHINGTON, D.C. – EM hosted the Environmental Management Contract Performance and Management Workshop at DOE headquarters Wednesday.

  10. Acquisition Career Management Program Handbook, Partial Revision...

    Energy.gov (indexed) [DOE]

    Procurement and Assistance Management SUBJECT: Acquisition Career Management Program Handbook, Partial Revision of Chapter 11, Contracting Officer's Representative SUMMARY: The...

  11. Comprehensive Legacy Management and Institutional Controls Plan

    Office of Legacy Management (LM)

    Department of Energy Comprehensive Legacy Management and Institutional Controls Plan Doc. .........32 Comprehensive Legacy Management and Institutional Controls ...

  12. Fernald Environmental Management Project Archived Soil & Groundwater...

    Office of Environmental Management (EM)

    Fernald Environmental Management Project Archived Soil & Groundwater Master Reports Fernald Environmental Management Project Archived Soil & Groundwater Master Reports Fernald ...

  13. Miamisburg Environmental Management Project Archived Soil & Groundwate...

    Office of Environmental Management (EM)

    Miamisburg Environmental Management Project Archived Soil & Groundwater Master Reports Miamisburg Environmental Management Project Archived Soil & Groundwater Master Reports ...

  14. Business Opportunities Session Office of Environmental Management...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Opportunities Session Office of Environmental Management Business Opportunities Session Office of Environmental Management Environmental Clean up PDF icon Business Opportunities ...

  15. Environmental Management Headquarters Corrective Action Plan...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    II Environmental Management Headquarters Corrective Action Plan - Radiological Release ... actions for addressing Office of Environmental Management (EM) Headquarters (HQ) ...

  16. Waste shipment engineering data management plan

    SciTech Connect (OSTI)

    Marquez, D.L.

    1995-05-01

    This plan documents current data management practices and future data management improvements for TWRS Waste Shipment Engineering.

  17. Federal Spectrum Management at the National Telecommunications...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Federal Spectrum Management at the National Telecommunications and Information Administration Federal Spectrum Management at the National Telecommunications and Information ...

  18. Enterprise Assessments Review of Radioactive Waste Management...

    Office of Environmental Management (EM)

    Radioactive Waste Management at the Portsmouth Gaseous Diffusion Plant December 2015 ......... 2 5.1 Radioactive Waste Management Planning ......

  19. Management and Operating Contractors' Subcontract Audit Coverage...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Management and Operating Contractors' Subcontract Audit Coverage DOEIG-0885 April 2013 ... INFORMATION: Special Report on "Management and Operating Contractors' Subcontract ...

  20. Comprehensive Legacy Management and Institutional Controls Plan

    Office of Legacy Management (LM)

    Department of Energy Comprehensive Legacy Management and Institutional Controls Plan Doc. .........49 Comprehensive Legacy Management and Institutional Controls ...

  1. Comprehensive Legacy Management and Institutional Controls Plan

    Office of Legacy Management (LM)

    Department of Energy Comprehensive Legacy Management and Institutional Controls Plan Doc. .........33 Comprehensive Legacy Management and Institutional Controls ...

  2. Comprehensive Legacy Management and Institutional Controls Plan

    Office of Legacy Management (LM)

    Department of Energy Comprehensive Legacy Management and Institutional Controls Plan Doc. .........34 Comprehensive Legacy Management and Institutional Controls ...

  3. Comprehensive Legacy Management and Institutional Controls Plan

    Office of Legacy Management (LM)

    Department of Energy Comprehensive Legacy Management and Institutional Controls Plan Doc. .........52 Comprehensive Legacy Management and Institutional Controls ...

  4. Project Management Lessons Learned (PMLL) Repository | Department...

    Energy Savers

    Information Systems Project Management Lessons Learned (PMLL) Repository Project Management Lessons Learned (PMLL) Repository The Department of Energy utilizes Project ...

  5. EERE Program Management Guide - About the Program Management...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Renewable Energy (EERE) environment, many Program Managers and their teams bring to the job educational backgrounds and work experiences that are focused on science and technology. ...

  6. NS&T MANAGEMENT OBSERVATIONS

    SciTech Connect (OSTI)

    Gianotto, David

    2014-06-01

    The INL Management Observation Program (MOP) is designed to improve managers and supervisors understanding of work being performed by employees and the barriers impacting their success. The MOP also increases workers understanding of managements’ expectations as they relate to safety, security, quality, and work performance. Management observations (observations) are designed to improve the relationship and trust between employees and managers through increased engagement and interactions between managers and researchers in the field. As part of continuous improvement, NS&T management took initiative to focus on the participation and quality of observations in FY 14. This quarterly report is intended to (a) summarize the participation and quality of management’s observations, (b) assess observations for commonalities or trends related to facility or process barriers impacting research, and (c) provide feedback and make recommendations for improvements NS&T’s MOP.

  7. FLUOR HANFORD SAFETY MANAGEMENT PROGRAMS

    SciTech Connect (OSTI)

    GARVIN, L. J.; JENSEN, M. A.

    2004-04-13

    This document summarizes safety management programs used within the scope of the ''Project Hanford Management Contract''. The document has been developed to meet the format and content requirements of DOE-STD-3009-94, ''Preparation Guide for US. Department of Energy Nonreactor Nuclear Facility Documented Safety Analyses''. This document provides summary descriptions of Fluor Hanford safety management programs, which Fluor Hanford nuclear facilities may reference and incorporate into their safety basis when producing facility- or activity-specific documented safety analyses (DSA). Facility- or activity-specific DSAs will identify any variances to the safety management programs described in this document and any specific attributes of these safety management programs that are important for controlling potentially hazardous conditions. In addition, facility- or activity-specific DSAs may identify unique additions to the safety management programs that are needed to control potentially hazardous conditions.

  8. Shopping for outage management systems

    SciTech Connect (OSTI)

    Chou, Y.C.; Konneker, L.K.; Watkins, T.R.

    1995-12-31

    Customer service is becoming increasingly important to electric utilities. Outage management is an important part of customer service. Good outage management means quickly responding to outages and keeping customers informed about outages. Each outage equals lost customer satisfaction and lost revenue. Outage management is increasingly important because of new competition among utilities for customers, pressure from regulators, and internal pressure to cut costs. The market has several existing software products for outage management. How does a utility judge whether these products satisfy their specific needs? Technology is changing rapidly to support outage management. Which technology is proven and cost-effective? The purpose of this paper is to outline the procedure for evaluating outage management systems, and to discuss the key features to look for. It also gives our opinion of the features that represent state of the art. This paper will not discuss specific products or list vendors names.

  9. NS&T Management Observations

    SciTech Connect (OSTI)

    Gianotto, David

    2014-09-01

    The INL Management Observation Program (MOP) is designed to improve managers and supervisors understanding of work being performed by employees and the barriers impacting their success. The MOP also increases workers understanding of managements’ expectations as they relate to safety, security, quality, and work performance. Management observations (observations) are designed to improve the relationship and trust between employees and managers through increased engagement and interactions between managers and researchers in the field. As part of continuous improvement, NS&T management took initiative to focus on the participation and quality of observations in FY 14. This quarterly report is intended to (a) summarize the participation and quality of management’s observations, (b) assess observations for commonalities or trends related to facility or process barriers impacting research, and (c) provide feedback and make recommendations for improvements NS&T’s MOP.

  10. WIPP Project Records Management Handbook

    SciTech Connect (OSTI)

    Not Available

    1991-01-01

    The Waste Isolation Pilot Plant (WIPP) Records Management Handbook provides the WIPP Project Records Management personnel with a tool to use to fulfill the requirements of the WIPP Records Program and direct their actions in the important area of records management. The handbook describes the various project areas involved in records management, and how they function. The handbook provides the requirements for Record Coordinators and Master Record Center (MRC) personnel to follow in the normal course of file management, records scheduling, records turnover, records disposition, and records retrieval. More importantly, the handbook provides a single reference which encompasses the procedures set fourth in DOE Order 1324.2A, Records Disposition'' ASME NQA-1, Quality Assurance Program Requirements for Nuclear Facilities'' and DOE-AL 5700.6B, General Operations Quality Assurance.'' These documents dictate how an efficient system of records management will be achieved on the WIPP Project.

  11. Computerized training management system

    DOE Patents [OSTI]

    Rice, H.B.; McNair, R.C.; White, K.; Maugeri, T.

    1998-08-04

    A Computerized Training Management System (CTMS) is disclosed for providing a procedurally defined process that is employed to develop accreditable performance based training programs for job classifications that are sensitive to documented regulations and technical information. CTMS is a database that links information needed to maintain a five-phase approach to training-analysis, design, development, implementation, and evaluation independent of training program design. CTMS is designed using R-Base{trademark}, an-SQL compliant software platform. Information is logically entered and linked in CTMS. Each task is linked directly to a performance objective, which, in turn, is linked directly to a learning objective; then, each enabling objective is linked to its respective test items. In addition, tasks, performance objectives, enabling objectives, and test items are linked to their associated reference documents. CTMS keeps all information up to date since it automatically sorts, files and links all data; CTMS includes key word and reference document searches. 18 figs.

  12. Computerized training management system

    DOE Patents [OSTI]

    Rice, Harold B.; McNair, Robert C.; White, Kenneth; Maugeri, Terry

    1998-08-04

    A Computerized Training Management System (CTMS) for providing a procedurally defined process that is employed to develop accreditable performance based training programs for job classifications that are sensitive to documented regulations and technical information. CTMS is a database that links information needed to maintain a five-phase approach to training-analysis, design, development, implementation, and evaluation independent of training program design. CTMS is designed using R-Base.RTM., an-SQL compliant software platform. Information is logically entered and linked in CTMS. Each task is linked directly to a performance objective, which, in turn, is linked directly to a learning objective; then, each enabling objective is linked to its respective test items. In addition, tasks, performance objectives, enabling objectives, and test items are linked to their associated reference documents. CTMS keeps all information up to date since it automatically sorts, files and links all data; CTMS includes key word and reference document searches.

  13. Program Management Review Opening Presentation

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    July 30, 2013 Valerie Reed Acting Director Program Management Review Bioenergy Technologies Office 2 Program Management Review May 20-24 th - Alexandria, VA * 219 projects reviewed * $1.595 Billion * 42 External Reviewers July 30th - Washington, D.C. * Project Review Results * 7 Key Platforms * BETO Programmatic Presentations * 7 Steering Committee Members 3 Peer Review Process 2013 Peer Review BETO Steering Group  Valerie Reed, Acting Director  Kevin Craig, Conversion Program Manager

  14. Human factors in waste management

    SciTech Connect (OSTI)

    Moray, N.

    1994-10-01

    This article examines the role of human factors in radioactive waste management. Although few problems and ergonomics are special to radioactive waste management, some problems are unique especially with long term storage. The entire sociotechnical system must be looked at in order to see where improvement can take place because operator errors, as seen in Chernobyl and Bhopal, are ultimately the result of management errors.

  15. Records Management | The Ames Laboratory

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Management Records Management Records and Files The Department of Energy (DOE) Records Management Program provides oversight, guidance, and direction to ensure proper documentation of the Department's functions, decisions, policies and proceedures, and essential transactions. WHAT'S NEW: The National Archives and Records Administration (NARA) now provides access to scanned images of Federal agency records schedules. The National Archives Records Control Schedule (RCS) web site contains scanned

  16. Waste Management | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Management Waste Management Nuclear Materials Disposition Nuclear Materials Disposition In fulfilling its mission, EM frequently manages and completes disposition of surplus nuclear materials and spent nuclear fuel. These are not waste. They are nuclear materials no longer needed for national security or other purposes, including spent nuclear fuel, special nuclear materials (as defined by the Atomic Energy Act) and other Nuclear Materials. Read more Tank Waste and Waste Processing Tank Waste

  17. Incident Management | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Management Incident Management IC2 (004).jpg The Incident Management Program (IMP) focuses on: threat information sharing critical infrastructure protection active defense incident preparedness. The IMP reports all incidents to the United States Computer Emergency Readiness Team (US-CERT), fulfilling statutory requirements and ensuring a coordinated response to cyber attacks. Joint Cybersecurity Coordination Center (JC3) The Joint Cybersecurity Coordination Center (JC3) provides DOE with

  18. Records Management | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Management Records Management Records and Files The Department of Energy (DOE) Records Management Program provides oversight, guidance, and direction to ensure proper documentation of the Department's functions, decisions, policies and proceedures, and essential transactions. WHAT'S NEW: The National Archives and Records Administration (NARA) now provides access to scanned images of Federal agency records schedules. The National Archives Records Control Schedule (RCS) web site contains scanned

  19. ORISE: Integrated Safety Management (ISM)

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    minimization and pollution prevention. All ORAU programs and departments actively pursue continuous improvement, and the addition of Integrated Safety Management (ISM) concepts...

  20. Energy Management and Marketing Specialist

    Energy.gov [DOE]

    (See Frequently Asked Questions for more information). Where would I be working? Western Area Power Administration, Upper Great Plains Region (UGP), Power Marketing, Energy Management and Marketing...