National Library of Energy BETA

Sample records for link biological systems

  1. Enhancing the role of veterinary vaccines reducing zoonotic diseases of humans: Linking systems biology with vaccine development

    SciTech Connect

    Adams, Leslie G.; Khare, Sangeeta; Lawhon, Sara D.; Rossetti, Carlos A.; Lewin, Harris A.; Lipton, Mary S.; Turse, Joshua E.; Wylie, Dennis C.; Bai, Yu; Drake, Kenneth L.

    2011-09-22

    The aim of research on infectious diseases is their prevention, and brucellosis and salmonellosis as such are classic examples of worldwide zoonoses for application of a systems biology approach for enhanced rational vaccine development. When used optimally, vaccines prevent disease manifestations, reduce transmission of disease, decrease the need for pharmaceutical intervention, and improve the health and welfare of animals, as well as indirectly protecting against zoonotic diseases of people. Advances in the last decade or so using comprehensive systems biology approaches linking genomics, proteomics, bioinformatics, and biotechnology with immunology, pathogenesis and vaccine formulation and delivery are expected to enable enhanced approaches to vaccine development. The goal of this paper is to evaluate the role of computational systems biology analysis of host:pathogen interactions (the interactome) as a tool for enhanced rational design of vaccines. Systems biology is bringing a new, more robust approach to veterinary vaccine design based upon a deeper understanding of the host pathogen interactions and its impact on the host's molecular network of the immune system. A computational systems biology method was utilized to create interactome models of the host responses to Brucella melitensis (BMEL), Mycobacterium avium paratuberculosis (MAP), Salmonella enterica Typhimurium (STM), and a Salmonella mutant (isogenic *sipA, sopABDE2) and linked to the basis for rational development of vaccines for brucellosis and salmonellosis as reviewed by Adams et al. and Ficht et al. [1,2]. A bovine ligated ileal loop biological model was established to capture the host gene expression response at multiple time points post infection. New methods based on Dynamic Bayesian Network (DBN) machine learning were employed to conduct a comparative pathogenicity analysis of 219 signaling and metabolic pathways and 1620 gene ontology (GO) categories that defined the host's biosignatures

  2. Genomics and Systems Biology

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Genomics and Systems Biology Los Alamos scientists perform research in functional genomics ... and experimental biology as the foundation of a dynamic systems biology capability. ...

  3. Biological conversion system

    DOEpatents

    Scott, C.D.

    A system for bioconversion of organic material comprises a primary bioreactor column wherein a biological active agent (zymomonas mobilis) converts the organic material (sugar) to a product (alcohol), a rejuvenator column wherein the biological activity of said biological active agent is enhanced, and means for circulating said biological active agent between said primary bioreactor column and said rejuvenator column.

  4. Genomics and Systems Biology

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Genomics and Systems Biology Genomics and Systems Biology Los Alamos scientists perform research in functional genomics and structural genomics, and applications for such work cover diverse fields such as energy, agriculture, and environmental cleanup. Contact Us Babetta Marrone Biofuels Program Manager Email Cheryl Kuske DOE BER Biological System Science Division Program Manager Email Kirsten McCabe Emerging Threats Program Manager Email Rebecca McDonald Bioscience Communications Email "We

  5. Genomics and Systems Biology

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Genomics and Systems Biology Los Alamos National Laboratory leads the world in computational finishing of microbial genomes Read caption + In 2013, Los Alamos scientist Richard Sayre and his team genetically modified the organisms to harvest light more efficiently for maximum production. Overview of Research and Highlights Researchers at Los Alamos National Laboratory are using their renowned expertise in genomics, computation, and experimental biology as the foundation of a dynamic systems

  6. 7th Annual Systems Biology Symposium: Systems Biology and Engineering

    SciTech Connect

    Galitski, Timothy P.

    2008-04-01

    Systems biology recognizes the complex multi-scale organization of biological systems, from molecules to ecosystems. The International Symposium on Systems Biology has been hosted by the Institute for Systems Biology in Seattle, Washington, since 2002. The annual two-day event gathers the most influential researchers transforming biology into an integrative discipline investingating complex systems. Engineering and application of new technology is a central element of systems biology. Genome-scale, or very small-scale, biological questions drive the enigneering of new technologies, which enable new modes of experimentation and computational analysis, leading to new biological insights and questions. Concepts and analytical methods in engineering are now finding direct applications in biology. Therefore, the 2008 Symposium, funded in partnership with the Department of Energy, featured global leaders in "Systems Biology and Engineering."

  7. Links

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Useful Links BIOSYNC: Structural Biology Synchrotron Users Organization X-ray Anomalous Scattering Going MAD at CHESS Protein Data Bank International Union of Crystallography ...

  8. Genomics and Systems Biology

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    This approach promises to enhance all aspects of biological research such as: * Increasing the specificity of pathogen detection * Designing more effective drugs through ...

  9. Adjustable link for kinematic mounting systems

    DOEpatents

    Hale, Layton C.

    1997-01-01

    An adjustable link for kinematic mounting systems. The adjustable link is a low-cost, passive device that provides backlash-free adjustment along its single constraint direction and flexural freedom in all other directions. The adjustable link comprises two spheres, two sockets in which the spheres are adjustable retain, and a connection link threadly connected at each end to the spheres, to provide a single direction of restraint and to adjust the length or distance between the sockets. Six such adjustable links provide for six degrees of freedom for mounting an instrument on a support. The adjustable link has applications in any machine or instrument requiring precision adjustment in six degrees of freedom, isolation from deformations of the supporting platform, and/or additional structural damping. The damping is accomplished by using a hollow connection link that contains an inner rod and a viscoelastic separation layer between the two.

  10. Adjustable link for kinematic mounting systems

    DOEpatents

    Hale, L.C.

    1997-07-01

    An adjustable link for kinematic mounting systems is disclosed. The adjustable link is a low-cost, passive device that provides backlash-free adjustment along its single constraint direction and flexural freedom in all other directions. The adjustable link comprises two spheres, two sockets in which the spheres are adjustable retain, and a connection link threadly connected at each end to the spheres, to provide a single direction of restraint and to adjust the length or distance between the sockets. Six such adjustable links provide for six degrees of freedom for mounting an instrument on a support. The adjustable link has applications in any machine or instrument requiring precision adjustment in six degrees of freedom, isolation from deformations of the supporting platform, and/or additional structural damping. The damping is accomplished by using a hollow connection link that contains an inner rod and a viscoelastic separation layer between the two. 3 figs.

  11. Systems biology approach to bioremediation

    SciTech Connect

    Chakraborty, Romy; Wu, Cindy H.; Hazen, Terry C.

    2012-06-01

    Bioremediation has historically been approached as a ‘black box’ in terms of our fundamental understanding. Thus it succeeds and fails, seldom without a complete understanding of why. Systems biology is an integrated research approach to study complex biological systems, by investigating interactions and networks at the molecular, cellular, community, and ecosystem level. The knowledge of these interactions within individual components is fundamental to understanding the dynamics of the ecosystem under investigation. Finally, understanding and modeling functional microbial community structure and stress responses in environments at all levels have tremendous implications for our fundamental understanding of hydrobiogeochemical processes and the potential for making bioremediation breakthroughs and illuminating the ‘black box’.

  12. Systems Biology in Prokaryote - Eukaryote Symbiosis | Stanford...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Systems Biology in Prokaryote - Eukaryote Symbiosis Monday, June 25, 2012 - 12:00pm SLAC, ... there are over 130 beamlines at synchrotrons worldwide devoted to structural biology. ...

  13. Method of measurement in biological systems

    DOEpatents

    Turteltaub, K.W.; Vogel, J.S.; Felton, J.S.; Gledhill, B.L.: Davis, J.C.; Stanker, L.H.

    1993-05-11

    A method is disclosed of quantifying molecules in biological substances, comprising: selecting a biological host in which radioisotopes are present in concentrations equal to or less than those in the ambient biosphere; preparing a long-lived radioisotope labeled reactive chemical specie; administering the chemical specie to the biological host in doses sufficiently low to avoid significant overt damage to the biological system; allowing a period of time to elapse sufficient for dissemination and interaction of the chemical specie with the host throughout the biological system of the host; isolating a reacted fraction of the biological substance from the host in a manner sufficient to avoid contamination of the substance from extraneous sources; converting the fraction of biological substance by suitable means to a material which efficiently produces charged ions in at least one of several possible ion sources without introduction of significant isotopic fractionation; and measuring the radioisotope concentration in the material by means of direct isotopic counting.

  14. Genomes, Phylogeny, and Evolutionary Systems Biology

    SciTech Connect

    Medina, Monica

    2005-03-25

    With the completion of the human genome and the growing number of diverse genomes being sequenced, a new age of evolutionary research is currently taking shape. The myriad of technological breakthroughs in biology that are leading to the unification of broad scientific fields such as molecular biology, biochemistry, physics, mathematics and computer science are now known as systems biology. Here I present an overview, with an emphasis on eukaryotes, of how the postgenomics era is adopting comparative approaches that go beyond comparisons among model organisms to shape the nascent field of evolutionary systems biology.

  15. Systems Biology in Prokaryote - Eukaryote Symbiosis | Stanford Synchrotron

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Radiation Lightsource Systems Biology in Prokaryote - Eukaryote Symbiosis Monday, June 25, 2012 - 12:00pm SLAC, SSRL Main Conference Room, 137-322 Allen M. Orville, Brookhaven National Laboratory Frontier challenges for macromolecular crystallography (MX) now include determining structures of trapped reactive intermediates, large macromolecules and viruses, membrane proteins, protein-protein complexes, and protein-nucleic acid complexes. Although structure and function are intimately linked,

  16. Method of measurement in biological systems

    DOEpatents

    Turteltaub, K.W.; Vogel, J.S.; Felton, J.S.; Gledhill, B.L.; Davis, J.C.

    1994-12-27

    Disclosed is a method of quantifying molecules in biological substances comprising: a. selecting a biological host in which radioisotopes are present in concentrations equal to or less than those in the ambient biosphere, b. preparing a long-lived radioisotope labeled reactive chemical specie, c. administering the chemical specie to the biological host in doses sufficiently low to avoid significant overt damage to the biological system, d. allowing a period of time to elapse sufficient for dissemination and interaction of the chemical specie with the host throughout the biological system of the host, e. isolating a reacted fraction of the biological substance from the host in a manner sufficient to avoid contamination of the substance from extraneous sources, f. converting the fraction of biological substance by suitable means to a material which efficiently produces charged ions in at least one of several possible ion sources without introduction of significant isotopic fractionation, and, g. measuring the radioisotope concentration in the material by means of direct isotopic counting. 5 figures.

  17. Method of measurement in biological systems

    DOEpatents

    Turteltaub, Kenneth W.; Vogel, John S.; Felton, James S.; Gledhill, Barton L.; Davis, Jay C.; Stanker, Larry H.

    1993-05-11

    Disclosed is a method of quantifying molecules in biological substances, comprising: a. selecting a biological host in which radioisotopes are present in concentrations equal to or less than those in the ambient biosphere, b. preparing a long-lived radioisotope labeled reactive chemical specie, c. administering said chemical specie to said biological host in doses sufficiently low to avoid significant overt damage to the biological system thereof, d. allowing a period of time to elapse sufficient for dissemination and interaction of said chemical specie with said host throughout said biological system of said host, e. isolating a reacted fraction of the biological substance from said host in a manner sufficient to avoid contamination of said substance from extraneous sources, f. converting said fraction of biological substance by suitable means to a material which efficiently produces charged ions in at least one of several possible ion sources without introduction of significant isotopic fractionation, and, g. measuring the radioisotope concentration in said material by means of direct isotopic counting.

  18. Method of measurement in biological systems

    DOEpatents

    Turteltaub, Kenneth W.; Vogel, John S.; Felton, James S.; Gledhill, Barton L.; Davis, Jay C.

    1994-01-01

    Disclosed is a method of quantifying molecules in biological substances comprising: a. selecting a biological host in which radioisotopes are present in concentrations equal to or less than those in the ambient biosphere, b. preparing a long-lived radioisotope labeled reactive chemical specie, c. administering said chemical specie to said biological host in doses sufficiently low to avoid significant overt damage to the biological system thereof, d. allowing a period of time to elapse sufficient for dissemination and interaction of said chemical specie with said host throughout said biological system of said host, e. isolating a reacted fraction of the biological substance from said host in a manner sufficient to avoid contamination of said substance from extraneous sources, f. converting said fraction of biological substance by suitable means to a material which efficiently produces charged ions in at least one of several possible ion sources without introduction of significant isotopic fractionation, and, g. measuring the radioisotope concentration in said material by means of direct isotopic counting.

  19. Renewable Hydrogen Production from Biological Systems

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Hydrogen Production from Biological Systems Matthew Posewitz Colorado School of Mines DOE Biological Hydrogen Production Workshop September 24 th , 2013 H 2 production PSII/PSI pathway PSI/nonphotochemical PQ Dark fermentation H 2 uptake oxyhydrogen reaction photoreduction Photosynthetic H 2 pathways Peters JW et al. Science 1998 Nicolet Y et al. Structure and Folding Des. 1999 Phototroph Hydrogenases * Cyanobacteria - Only [NiFe]-hydrogenases identified to date. - Typically dark H 2 production.

  20. Comparative systems biology across an evolutionary gradient within...

    Office of Scientific and Technical Information (OSTI)

    Comparative systems biology across an evolutionary gradient within the Shewanella genus Citation Details In-Document Search Title: Comparative systems biology across an ...

  1. Systems biology analysis of Zymomonas mobilis ZM4 ethanol stress...

    Office of Scientific and Technical Information (OSTI)

    Systems biology analysis of Zymomonas mobilis ZM4 ethanol stress responses Citation Details In-Document Search Title: Systems biology analysis of Zymomonas mobilis ZM4 ethanol ...

  2. Importance of systems biology in engineering microbes for biofuel...

    Office of Scientific and Technical Information (OSTI)

    Importance of systems biology in engineering microbes for biofuel production Citation Details In-Document Search Title: Importance of systems biology in engineering microbes for ...

  3. Document creation, linking, and maintenance system

    SciTech Connect

    Claghorn, Ronald

    2011-02-15

    A document creation and citation system designed to maintain a database of reference documents. The content of a selected document may be automatically scanned and indexed by the system. The selected documents may also be manually indexed by a user prior to the upload. The indexed documents may be uploaded and stored within a database for later use. The system allows a user to generate new documents by selecting content within the reference documents stored within the database and inserting the selected content into a new document. The system allows the user to customize and augment the content of the new document. The system also generates citations to the selected content retrieved from the reference documents. The citations may be inserted into the new document in the appropriate location and format, as directed by the user. The new document may be uploaded into the database and included with the other reference documents. The system also maintains the database of reference documents so that when changes are made to a reference document, the author of a document referencing the changed document will be alerted to make appropriate changes to his document. The system also allows visual comparison of documents so that the user may see differences in the text of the documents.

  4. Modular microfluidic system for biological sample preparation

    DOEpatents

    Rose, Klint A.; Mariella, Jr., Raymond P.; Bailey, Christopher G.; Ness, Kevin Dean

    2015-09-29

    A reconfigurable modular microfluidic system for preparation of a biological sample including a series of reconfigurable modules for automated sample preparation adapted to selectively include a) a microfluidic acoustic focusing filter module, b) a dielectrophoresis bacteria filter module, c) a dielectrophoresis virus filter module, d) an isotachophoresis nucleic acid filter module, e) a lyses module, and f) an isotachophoresis-based nucleic acid filter.

  5. Radiological/biological/aerosol removal system

    DOEpatents

    Haslam, Jeffery J

    2015-03-17

    An air filter replacement system for existing buildings, vehicles, arenas, and other enclosed airspaces includes a replacement air filter for replacing a standard air filter. The replacement air filter has dimensions and air flow specifications that allow it to replace the standard air filter. The replacement air filter includes a filter material that removes radiological or biological or aerosol particles.

  6. links

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Useful Links Other Cyclotrons National Superconducting Cyclotron Laboratory at Michigan State Univeristy Indiana University Cyclotron Facility Cyclotron Research Centre at Louvain 88" Cyclotron at Lawrence Berkley National Lab Department of Energy National Labs Brookhaven National Laboratory Lawrence Berkeley National Laboratory Fermi National Accelerator Laboratory Los Alamos National Laboratory Sandia National Laboratories Ames Laboratory Pacific Northwest National Laboratory Oak Ridge

  7. High performance control of harmonic instability from HVDC link system

    SciTech Connect

    Min, W.K.; Yoo, M.H.

    1995-12-31

    This paper investigates the usefulness of novel control method for HVDC link system which suffers from severe condition of low order harmonic. This control scheme is used the feedforward control method which is directly controlled dc current at dc link system. The studies of this paper are aimed to improving the dynamic response of HVdc link system in disturbances such as faults. To achieve those objectives, digital time domain simulations are employed by the electro magnetic transient program for dc system (EMTDC). This method results in stable recovery from faults at both rectifier and inverter terminal busbars for a HVdc system that is inherently unstable. It has been found to be robust and control performance has been enhanced.

  8. Links

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Links: CAMD's SAXS beamline sister page By Derek Dorman General Reference: Glatter and Kratky Small Angle X-ray Scattering Book (subject to the permission letter and terms of use) SAXS Presentation by Jianhua Li SAXS Presentation by John Pople Dr. Brian Grady's Polymer Characterization Group SAXS page Jun, Y., Waychunas, G. "Molecular-Level Investigations of Nucleation Mechanisms and Kinetics of Formation of Environmental Nanoparticles" Poster SAXS Analysis/Simulation: Paul Scherrer

  9. KPFM and PFM of Biological Systems

    SciTech Connect

    Rodriguez, Brian [University College, Dublin; Kalinin, Sergei V [ORNL

    2011-01-01

    Surface potentials and electrostatic interactions in biological systems are a key element of cellular regulation and interaction. Examples include cardiac and muscular activity, voltage-gated ion channels, protein folding and assembly, and electroactive cells and electrotransduction. The coupling between electrical, mechanical, and chemical signals and responses in cellular systems necessitates the development of tools capable of measuring the distribution of charged species, surface potentials, and mechanical responses to applied electrical stimuli and vice versa, ultimately under physiological conditions. In this chapter, applications of voltage-modulated atomic force microscopy (AFM) methods including Kelvin probe force microscopy (KPFM) and piezoresponse force microscopy (PFM) to biological systems are discussed. KPFM is a force-sensitive non-contact or intermittent-contact mode AFM technique that allows electrostatic interactions and surface potentials to be addressed. Beyond long-range electrostatic interactions, the application of bias can lead to a mechanical response, e.g., due to linear piezoelectric coupling in polar biopolymers or via more complex electrotransduction and redox pathways in other biosystems. The use and development of PFM, based on direct electromechanical detection, to biological systems will also be addressed. The similarities and limitations of measuring surface potentials and electromechanical coupling in solution will be outlined.

  10. Reliability assessment of autonomous power systems incorporating HVDC interconnection links

    SciTech Connect

    Dialynas, E.N.; Koskolos, N.C.; Agoris, D.

    1996-01-01

    The objective of this paper is to present an improved computational method for the overall reliability assessment of autonomous power systems that may or may not contain HVdc interconnection links. This is a hybrid method based on a Monte-Carlo simulation sequential approach which incorporates an analytical approach for the reliability modeling of the HVdc transmission links. The developed models and techniques have been implemented into a computer program that can be used to simulate the operational practices and characteristics of the overall system under study efficiently and realistically. A set of reliability indices are calculated for each load-point of interest and the entire system while a set of additional indices is calculated for quantifying the reliability performance of the interconnection links under the specified operating requirements. The analysis of a practical system is also included for a number of studies representing its various operating and design characteristics.

  11. Method for photo-altering a biological system to improve biological effect

    DOEpatents

    Hill, Richard A.; Doiron, Daniel R.; Crean, David H.

    2000-08-01

    Photodynamic therapy is a new adjunctive therapy for filtration surgery that does not use chemotherapy agents or radiation, but uses pharmacologically-active sensitizing compounds to produce a titratable, localized, transient, post operative avascular conjunctiva. A photosensitizing agent in a biological system is selectively activated by delivering the photosensitive agent to the biological system and laser activating only a spatially selected portion of the delivered photosensitive agent. The activated portion of the photosensitive agent reacts with the biological system to obtain a predetermined biological effect. As a result, an improved spatial disposition and effectuation of the biological effect by the photosensitive agent in the biological system is achieved.

  12. Cross-Linking and Mass Spectrometry Methodologies to Facilitate Structural Biology: Finding a Path through the Maze

    SciTech Connect

    Merkley, Eric D.; Cort, John R.; Adkins, Joshua N.

    2013-09-01

    Multiprotein complexes, rather than individual proteins, make up a large part of the biological macromolecular machinery of a cell. Understanding the structure and organization of these complexes is critical to understanding cellular function. Chemical cross-linking coupled with mass spectrometry is emerging as a complementary technique to traditional structural biology methods and can provide low-resolution structural information for a multitude of purposes, such as distance constraints in computational modeling of protein complexes. In this review, we discuss the experimental considerations for successful application of chemical cross-linking-mass spectrometry in biological studies and highlight three examples of such studies from the recent literature. These examples (as well as many others) illustrate the utility of a chemical cross-linking-mass spectrometry approach in facilitating structural analysis of large and challenging complexes.

  13. 6th Annual Systems Biology Symposium: Systems Biology and the Environment

    SciTech Connect

    Galitski, Timothy, P.

    2007-04-01

    Systems biology recognizes the complex multi-scale organization of biological systems, from molecules to ecosystems. The International Symposium on Systems Biology is an annual two-day event gathering the most influential researchers transforming biology into an integrative discipline investigating complex systems. In recognition of the fundamental similarity between the scientific problems addressed in environmental science and systems biology studies at the molecular, cellular, and organismal levels, the 2007 Symposium featured global leaders in “Systems Biology and the Environment.” The objective of the 2007 “Systems Biology and the Environment” International Symposium was to stimulate interdisciplinary thinking and research that spans systems biology and environmental science. This Symposium was well aligned with the DOE’s Genomics:GTL program efforts to achieve scientific objectives for each of the three DOE missions: • Develop biofuels as a major secure energy source for this century, • Develop biological solutions for intractable environmental problems, and • Understand biosystems’ climate impacts and assess sequestration strategies Our scientific program highlighted world-class research exemplifying these priorities. The Symposium featured 45 minute lectures from 12 researchers including: Penny/Sallie Chisholm of MIT gave the keynote address “Tiny Cells, Global Impact: What Prochlorococcus Can Teach Us About Systems Biology”, plus Jim Fredrickson of PNNL, Nitin Baliga of ISB, Steve Briggs of UCSD, David Cox of Perlegen Sciences, Antoine Danchin of Institut Pasteur, John Delaney of the U of Washington, John Groopman of Johns Hopkins, Ben Kerr of the U of Washington, Steve Koonin of BP, Elliott Meyerowitz of Caltech, and Ed Rubin of LBNL. The 2007 Symposium promoted DOE’s three mission areas among scientists from multiple disciplines representing academia, non-profit research institutions, and the private sector. As in all previous

  14. AN INTEGRATED BIOLOGICAL CONTROL SYSTEM AT HANFORD

    SciTech Connect

    JOHNSON AR; CAUDILL JG; GIDDINGS RF; RODRIGUEZ JM; ROOS RC; WILDE JW

    2010-02-11

    In 1999 an integrated biological control system was instituted at the U.S. Department of Energy's Hanford Site. Successes and changes to the program needed to be communicated to a large and diverse mix of organizations and individuals. Efforts at communication are directed toward the following: Hanford Contractors (Liquid or Tank Waste, Solid Waste, Environmental Restoration, Science and Technology, Site Infrastructure), General Hanford Employees, and Hanford Advisory Board (Native American Tribes, Environmental Groups, Local Citizens, Washington State and Oregon State regulatory agencies). Communication was done through direct interface meetings, individual communication, where appropriate, and broadly sharing program reports. The objectives of the communication efforts was to have the program well coordinated with Hanford contractors, and to have the program understood well enough that all stakeholders would have confidence in the work performed by the program to reduce or elimated spread of radioactive contamination by biotic vectors. Communication of successes and changes to an integrated biological control system instituted in 1999 at the Department of Energy's Hanford Site have required regular interfaces with not only a diverse group of Hanford contractors (i.e., those responsible for liquid or tank waste, solid wastes, environmental restoration, science and technology, and site infrastructure), and general Hanford employees, but also with a consortium of designated stake holders organized as the Hanford Advisory Board (i.e., Native American tribes, various environmental groups, local citizens, Washington state and Oregon regulatory agencies, etc.). Direct interface meetings, individual communication where appropriate, and transparency of the biological control program were the methods and outcome of this effort.

  15. Biological Systems for Hydrogen Photoproduction (Presentation)

    SciTech Connect

    Ghirardi, M. L.

    2012-05-01

    This presentation summarizes NREL biological systems for hydrogen photoproduction work for the DOE Hydrogen and Fuel Cells Program Annual Merit Review and Peer Evaluation Meeting, May 14-18, 2012. General goal is develop photobiological systems for large-scale, low cost and efficient H{sub 2} production from water (barriers AH, AI and AJ). Specific tasks are: (1) Address the O{sub 2} sensitivity of hydrogenases that prevent continuity of H{sub 2} photoproduction under aerobic, high solar-to-hydrogen (STH) light conversion efficiency conditions; and (2) Utilize a limited STH H{sub 2}-producing method (sulfur deprivation) as a platform to address or test other factors limiting commercial algal H{sub 2} photoproduction, including low rates due to biochemical and engineering mechanisms.

  16. Adding Links in Energy.gov Content Management System | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energy.gov Content Management System » Adding Links in Energy.gov Content Management System Adding Links in Energy.gov Content Management System For Office of Energy Efficiency and Renewable Energy (EERE) websites, to add a link in the Energy.gov Drupal content management system (CMS), follow these steps: Edit the page (also called a node) that you want to add a link to. Select the text you want to link. Click the "Link" button. Then: If you are linking to a page on Energy.gov, select

  17. Genomics and Systems Biology of Tuberculosis (2009 JGI User Meeting)

    ScienceCinema

    Galagan, James

    2016-07-12

    James Galagan from the Broad Institute spoke about the "Genomics and Systems Biology of TB" on March 26, 2009 during the 4th Annual User Meeting

  18. Renewable Hydrogen Production from Biological Systems

    Office of Energy Efficiency and Renewable Energy (EERE)

    Presentation by Matthew Posewitz, Colorado School of Mines, at the Biological Hydrogen Production Workshop held September 24-25, 2013, at the National Renewable Energy Laboratory in Golden, Colorado.

  19. Linking Automated Data Analysis and Visualization with Applications in Developmental Biology and High-Energy Physics

    SciTech Connect

    Ruebel, Oliver

    2009-12-01

    Knowledge discovery from large and complex collections of today's scientific datasets is a challenging task. With the ability to measure and simulate more processes at increasingly finer spatial and temporal scales, the increasing number of data dimensions and data objects is presenting tremendous challenges for data analysis and effective data exploration methods and tools. Researchers are overwhelmed with data and standard tools are often insufficient to enable effective data analysis and knowledge discovery. The main objective of this thesis is to provide important new capabilities to accelerate scientific knowledge discovery form large, complex, and multivariate scientific data. The research covered in this thesis addresses these scientific challenges using a combination of scientific visualization, information visualization, automated data analysis, and other enabling technologies, such as efficient data management. The effectiveness of the proposed analysis methods is demonstrated via applications in two distinct scientific research fields, namely developmental biology and high-energy physics.Advances in microscopy, image analysis, and embryo registration enable for the first time measurement of gene expression at cellular resolution for entire organisms. Analysis of high-dimensional spatial gene expression datasets is a challenging task. By integrating data clustering and visualization, analysis of complex, time-varying, spatial gene expression patterns and their formation becomes possible. The analysis framework MATLAB and the visualization have been integrated, making advanced analysis tools accessible to biologist and enabling bioinformatic researchers to directly integrate their analysis with the visualization. Laser wakefield particle accelerators (LWFAs) promise to be a new compact source of high-energy particles and radiation, with wide applications ranging from medicine to physics. To gain insight into the complex physical processes of particle

  20. A Systems Biology Platform for Characterizing Regulatory and Metabolic

    Office of Scientific and Technical Information (OSTI)

    Pathways that Influence and Control Microbial Hydrogen Production (Technical Report) | SciTech Connect A Systems Biology Platform for Characterizing Regulatory and Metabolic Pathways that Influence and Control Microbial Hydrogen Production Citation Details In-Document Search Title: A Systems Biology Platform for Characterizing Regulatory and Metabolic Pathways that Influence and Control Microbial Hydrogen Production Authors: Collins, James J [1] + Show Author Affiliations Boston University

  1. Chemical Biological Emergency Management Information System

    Energy Science and Technology Software Center

    2004-06-15

    CB-EMIS is designed to provide information and analysis to transit system operators and emergency responders in the event of a chemical attack on a subway system. The software inforporates detector data, video images, train data, meteorological data, and above- and below-ground plume dispersion models, hight of the liquid level.

  2. Computational Proteomics: High-throughput Analysis for Systems Biology

    SciTech Connect

    Cannon, William R.; Webb-Robertson, Bobbie-Jo M.

    2007-01-03

    High-throughput (HTP) proteomics is a rapidly developing field that offers the global profiling of proteins from a biological system. The HTP technological advances are fueling a revolution in biology, enabling analyses at the scales of entire systems (e.g., whole cells, tumors, or environmental communities). However, simply identifying the proteins in a cell is insufficient for understanding the underlying complexity and operating mechanisms of the overall system. Systems level investigations are relying more and more on computational analyses, especially in the field of proteomics generating large-scale global data.

  3. Behavior of REE in geological and biological systems

    SciTech Connect

    Laul, J.C.; Weimer, W.C.

    1981-05-01

    The REE abundances when normalized to primordial (chondritic) abundances behave as a smooth function of the REE ionic radii in both the geological and biological systems. The REE are hardly fractionated chemically through various stages of their transformation from soil-soil extract-plant-geological systems.

  4. Enabling a Systems Biology Knowledgebase with Gaggle and Firegoose

    SciTech Connect

    Baliga, Nitin S.

    2014-12-12

    The overall goal of this project was to extend the existing Gaggle and Firegoose systems to develop an open-source technology that runs over the web and links desktop applications with many databases and software applications. This technology would enable researchers to incorporate workflows for data analysis that can be executed from this interface to other online applications. The four specific aims were to (1) provide one-click mapping of genes, proteins, and complexes across databases and species; (2) enable multiple simultaneous workflows; (3) expand sophisticated data analysis for online resources; and enhance open-source development of the Gaggle-Firegoose infrastructure. Gaggle is an open-source Java software system that integrates existing bioinformatics programs and data sources into a user-friendly, extensible environment to allow interactive exploration, visualization, and analysis of systems biology data. Firegoose is an extension to the Mozilla Firefox web browser that enables data transfer between websites and desktop tools including Gaggle. In the last phase of this funding period, we have made substantial progress on development and application of the Gaggle integration framework. We implemented the workspace to the Network Portal. Users can capture data from Firegoose and save them to the workspace. Users can create workflows to start multiple software components programmatically and pass data between them. Results of analysis can be saved to the cloud so that they can be easily restored on any machine. We also developed the Gaggle Chrome Goose, a plugin for the Google Chrome browser in tandem with an opencpu server in the Amazon EC2 cloud. This allows users to interactively perform data analysis on a single web page using the R packages deployed on the opencpu server. The cloud-based framework facilitates collaboration between researchers from multiple organizations. We have made a number of enhancements to the cmonkey2 application to enable and

  5. Biology

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Biology @WIPP Life Begins at 250,000,000 Years WIPP's underground isn't just suited for ... radiation, one biology experiment actually conducts tests related to this phenomenon. ...

  6. Request for Travel Funds for Systems Radiation Biology Workshop

    SciTech Connect

    Barcellos-Hoff, Mary Helen

    2014-03-22

    The 3rd International Systems Radiation Biology Workshop brought together the major European, US and Japanese research programs on radiation risk as well as selected experts representing systems biological approaches to discuss how the new methodologies could be best exploited for low dose research. A significant part of the workshop was devoted to discussions organised as breakout group sessions. To facilitate discussions number of participants was limited to 60 persons. To achieve the goals of this symposium in this international conference, support from DOE is vital. Hence, this proposal requested support in the amount of $15,000 to cover the travel expenses of international experts and radiation biology scientists from the United States. This supporting mechanism was clearly identified to the selected US participants as a conference support award from the DOE (See attached PDF). The workshop was an outstanding opportunity to strengthen interactions between leading experts in the emerging areas of radiation sciences, and will also provide opportunities for younger scientists to meet with experts and discuss their results. This workshop was designed to endorse active engagement in international collaboration. A major objective of this conference was to effectively communicate research results, in order to ensure that current thinking reflects sound science of radiation biology. Further, this international event addressed the use and success of scientific initiatives in radiation biology for policymakers, standard-setters, and the general public.

  7. Biological optimization systems for enhancing photosynthetic efficiency and methods of use

    DOEpatents

    Hunt, Ryan W; Chinnasamy, Senthil; Das, Keshav C; Rolim de Mattos, Erico

    2014-02-25

    The present disclosure relates to biological optimization systems for enhancing photosynthetic efficiency and methods of use.

  8. FRAMES Software System: Linking to the Statistical Package R

    SciTech Connect

    Castleton, Karl J.; Whelan, Gene; Hoopes, Bonnie L.

    2006-12-11

    This document provides requirements, design, data-file specifications, test plan, and Quality Assurance/Quality Control protocol for the linkage between the statistical package R and the Framework for Risk Analysis in Multimedia Environmental Systems (FRAMES) Versions 1.x and 2.0. The requirements identify the attributes of the system. The design describes how the system will be structured to meet those requirements. The specification presents the specific modifications to FRAMES to meet the requirements and design. The test plan confirms that the basic functionality listed in the requirements (black box testing) actually functions as designed, and QA/QC confirms that the software meets the client’s needs.

  9. Systems Biology Knowledgebase for a New Era in Biology A Genomics:GTL Report from the May 2008 Workshop

    SciTech Connect

    Gregurick, S.; Fredrickson, J. K.; Stevens, R.

    2009-03-01

    Biology has entered a systems-science era with the goal to establish a predictive understanding of the mechanisms of cellular function and the interactions of biological systems with their environment and with each other. Vast amounts of data on the composition, physiology, and function of complex biological systems and their natural environments are emerging from new analytical technologies. Effectively exploiting these data requires developing a new generation of capabilities for analyzing and managing the information. By revealing the core principles and processes conserved in collective genomes across all biology and by enabling insights into the interplay between an organism's genotype and its environment, systems biology will allow scientific breakthroughs in our ability to project behaviors of natural systems and to manipulate and engineer managed systems. These breakthroughs will benefit Department of Energy (DOE) missions in energy security, climate protection, and environmental remediation.

  10. Biological Systems Science Division (BSSD) | U.S. DOE Office of Science

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    (SC) Biological Systems Science Division (BSSD) Biological and Environmental Research (BER) BER Home About Research Biological Systems Science Division (BSSD) Genomic Science DOE Bioenergy Research Centers Bioimaging Technology DOE Joint Genome Institute Structural Biology Radiochemistry & Imaging Instrumentation Radiobiology: Low Dose Radiation Research DOE Human Subjects Protection Program Climate and Environmental Sciences Division (CESD) Research Abstracts Searchable Archive of BER

  11. Embedded calibration system for the DIII-D Langmuir probe analog fiber optic links

    SciTech Connect

    Watkins, J. G. [Sandia National Laboratories, Livermore, California (United States); Rajpal, R.; Mandaliya, H. [Institute for Plasma Research, Bhat, Gandhinagar, Gujarat (India); Watkins, M.; Boivin, R. L. [General Atomics, San Diego, California (United States)

    2012-10-15

    This paper describes a generally applicable technique for simultaneously measuring offset and gain of 64 analog fiber optic data links used for the DIII-D fixed Langmuir probes by embedding a reference voltage waveform in the optical transmitted signal before every tokamak shot. The calibrated data channels allow calibration of the power supply control fiber optic links as well. The array of fiber optic links and the embedded calibration system described here makes possible the use of superior modern data acquisition electronics in the control room.

  12. Protecting a HVDC link against accidental isolation from its receiving AC system

    SciTech Connect

    Whitehouse, R.S. )

    1993-07-01

    When an HVdc scheme is isolated from its receiving ac system, the inverter may continue to operate, generating its own ac bus voltages; this is defined here as islanding. If islanding is allowed to continue unrestricted, then main circuit components may in some conditions be damaged and it is therefore necessary to provide a suitable protection system. This paper outlines the protection scheme developed for the McNeill Back-to-Back HVdc link in Alberta, Canada, to prevent damage due to islanding while still permitting the link to automatically restart on reclosure of the isolating breaker. Oscillograms showing the protection in operation on both the GEC ALSTHOM HVdc simulator and during tests carried out as part of the commissioning of the McNeill HV dc link are included.

  13. Systems biology-guided biodesign of consolidated lignin conversion

    DOE PAGES [OSTI]

    Lin, Lu; Cheng, Yanbing; Pu, Yunqiao; Sun, Su; Li, Xiao; Jin, Mingjie; Pierson, Elizabeth A.; Gross, Dennis C.; Dale, Bruce E.; Dai, Susie Y.; et al

    2016-07-12

    Lignin is the second most abundant biopolymer on the earth, yet its utilization for fungible products is complicated by its recalcitrant nature and remains a major challenge for sustainable lignocellulosic biorefineries. In this study, we used a systems biology approach to reveal the carbon utilization pattern and lignin degradation mechanisms in a unique lignin-utilizing Pseudomonas putida strain (A514). The mechanistic study further guided the design of three functional modules to enable a consolidated lignin bioconversion route. First, P. putida A514 mobilized a dye peroxidase-based enzymatic system for lignin depolymerization. This system could be enhanced by overexpressing a secreted multifunctional dyemore » peroxidase to promote a two-fold enhancement of cell growth on insoluble kraft lignin. Second, A514 employed a variety of peripheral and central catabolism pathways to metabolize aromatic compounds, which can be optimized by overexpressing key enzymes. Third, the β-oxidation of fatty acid was up-regulated, whereas fatty acid synthesis was down-regulated when A514 was grown on lignin and vanillic acid. Therefore, the functional module for polyhydroxyalkanoate (PHA) production was designed to rechannel β-oxidation products. As a result, PHA content reached 73% per cell dry weight (CDW). Further integrating the three functional modules enhanced the production of PHA from kraft lignin and biorefinery waste. Furthermore, this study elucidated lignin conversion mechanisms in bacteria with potential industrial implications and laid out the concept for engineering a consolidated lignin conversion route.« less

  14. Improving Power System Modeling. A Tool to Link Capacity Expansion and Production Cost Models

    SciTech Connect

    Diakov, Victor; Cole, Wesley; Sullivan, Patrick; Brinkman, Gregory; Margolis, Robert

    2015-11-01

    Capacity expansion models (CEM) provide a high-level long-term view at the prospects of the evolving power system. In simulating the possibilities of long-term capacity expansion, it is important to maintain the viability of power system operation in the short-term (daily, hourly and sub-hourly) scales. Production-cost models (PCM) simulate routine power system operation on these shorter time scales using detailed load, transmission and generation fleet data by minimizing production costs and following reliability requirements. When based on CEM 'predictions' about generating unit retirements and buildup, PCM provide more detailed simulation for the short-term system operation and, consequently, may confirm the validity of capacity expansion predictions. Further, production cost model simulations of a system that is based on capacity expansion model solution are 'evolutionary' sound: the generator mix is the result of logical sequence of unit retirement and buildup resulting from policy and incentives. The above has motivated us to bridge CEM with PCM by building a capacity expansion - to - production cost model Linking Tool (CEPCoLT). The Linking Tool is built to onset capacity expansion model prescriptions onto production cost model inputs. NREL's ReEDS and Energy Examplar's PLEXOS are the capacity expansion and the production cost models, respectively. Via the Linking Tool, PLEXOS provides details of operation for the regionally-defined ReEDS scenarios.

  15. Enhanced visible and near-infrared capabilities of the JET mirror-linked divertor spectroscopy system

    SciTech Connect

    Lomanowski, B. A. Sharples, R. M.; Meigs, A. G.; Conway, N. J.; Zastrow, K.-D.; Heesterman, P.; Kinna, D. [EURATOM Collaboration: JET-EFDA Team

    2014-11-15

    The mirror-linked divertor spectroscopy diagnostic on JET has been upgraded with a new visible and near-infrared grating and filtered spectroscopy system. New capabilities include extended near-infrared coverage up to 1875 nm, capturing the hydrogen Paschen series, as well as a 2 kHz frame rate filtered imaging camera system for fast measurements of impurity (Be II) and deuterium D?, D?, D? line emission in the outer divertor. The expanded system provides unique capabilities for studying spatially resolved divertor plasma dynamics at near-ELM resolved timescales as well as a test bed for feasibility assessment of near-infrared spectroscopy.

  16. The OME Framework for genome-scale systems biology

    SciTech Connect

    Palsson, Bernhard O.; Ebrahim, Ali; Federowicz, Steve

    2014-12-19

    The life sciences are undergoing continuous and accelerating integration with computational and engineering sciences. The biology that many in the field have been trained on may be hardly recognizable in ten to twenty years. One of the major drivers for this transformation is the blistering pace of advancements in DNA sequencing and synthesis. These advances have resulted in unprecedented amounts of new data, information, and knowledge. Many software tools have been developed to deal with aspects of this transformation and each is sorely needed [1-3]. However, few of these tools have been forced to deal with the full complexity of genome-scale models along with high throughput genome- scale data. This particular situation represents a unique challenge, as it is simultaneously necessary to deal with the vast breadth of genome-scale models and the dizzying depth of high-throughput datasets. It has been observed time and again that as the pace of data generation continues to accelerate, the pace of analysis significantly lags behind [4]. It is also evident that, given the plethora of databases and software efforts [5-12], it is still a significant challenge to work with genome-scale metabolic models, let alone next-generation whole cell models [13-15]. We work at the forefront of model creation and systems scale data generation [16-18]. The OME Framework was borne out of a practical need to enable genome-scale modeling and data analysis under a unified framework to drive the next generation of genome-scale biological models. Here we present the OME Framework. It exists as a set of Python classes. However, we want to emphasize the importance of the underlying design as an addition to the discussions on specifications of a digital cell. A great deal of work and valuable progress has been made by a number of communities [13, 19-24] towards interchange formats and implementations designed to achieve similar goals. While many software tools exist for handling genome

  17. Biologically-based signal processing system applied to noise removal for signal extraction

    DOEpatents

    Fu, Chi Yung; Petrich, Loren I.

    2004-07-13

    The method and system described herein use a biologically-based signal processing system for noise removal for signal extraction. A wavelet transform may be used in conjunction with a neural network to imitate a biological system. The neural network may be trained using ideal data derived from physical principles or noiseless signals to determine to remove noise from the signal.

  18. Reliability of unstable periodic orbit based control strategies in biological systems

    SciTech Connect

    Mishra, Nagender; Singh, Harinder P.; Hasse, Maria; Biswal, B.

    2015-04-15

    Presence of recurrent and statistically significant unstable periodic orbits (UPOs) in time series obtained from biological systems is now routinely used as evidence for low dimensional chaos. Extracting accurate dynamical information from the detected UPO trajectories is vital for successful control strategies that either aim to stabilize the system near the fixed point or steer the system away from the periodic orbits. A hybrid UPO detection method from return maps that combines topological recurrence criterion, matrix fit algorithm, and stringent criterion for fixed point location gives accurate and statistically significant UPOs even in the presence of significant noise. Geometry of the return map, frequency of UPOs visiting the same trajectory, length of the data set, strength of the noise, and degree of nonstationarity affect the efficacy of the proposed method. Results suggest that establishing determinism from unambiguous UPO detection is often possible in short data sets with significant noise, but derived dynamical properties are rarely accurate and adequate for controlling the dynamics around these UPOs. A repeat chaos control experiment on epileptic hippocampal slices through more stringent control strategy and adaptive UPO tracking is reinterpreted in this context through simulation of similar control experiments on an analogous but stochastic computer model of epileptic brain slices. Reproduction of equivalent results suggests that far more stringent criteria are needed for linking apparent success of control in such experiments with possible determinism in the underlying dynamics.

  19. EIA - Natural Gas Pipeline System - Links to U.S. Natural Gas...

    Energy Information Administration (EIA) (indexed site)

    Links About U.S. Natural Gas Pipelines - Transporting Natural Gas based on data through 20072008 with selected updates Links to U.S. Natural Gas Pipeline Information - The links ...

  20. Linking home energy rating systems with energy efficiency financing: Progress on national and state programs

    SciTech Connect

    Farhar, B.C.; Collins, N.E.; Walsh, R.W.

    1996-10-01

    In 1991 and early 1992, the U.S. Department of Energy (DOE), in cooperation with the U.S. Department of Housing and Urban Development (HUD), established a National Collaborative on Home Energy Rating Systems (HERS) and Energy Efficient Mortgages (EEMs). The Collaborative's purpose was to involve stakeholders at a national policy level to develop a plan leading the nation toward a voluntary system linking HERS with EEMs. The National Renewable Energy Laboratory (NREL) coordinated the National Collaborative's meetings for DOE. Composed of representatives from 25 stakeholder organizations, the Collaborative, after some 14 meetings, reached consensus on two documents, both published by NREL in mg 1992: A National Program for Energy-Efficient Mortgages and Home Energy Rating Systems: A Blueprint for Action and Going National with HERS and EEMs: Issues and Impacts, The Collected Papers of the National Collaborative.

  1. Structural Biology | U.S. DOE Office of Science (SC)

    Office of Science (SC)

    Structural Biology Biological and Environmental Research (BER) BER Home About Research Biological Systems Science Division (BSSD) Genomic Science DOE Bioenergy Research Centers Bioimaging Technology DOE Joint Genome Institute Structural Biology Radiochemistry & Imaging Instrumentation Radiobiology: Low Dose Radiation Research DOE Human Subjects Protection Program Climate and Environmental Sciences Division (CESD) Research Abstracts Searchable Archive of BER Highlights External link

  2. Building the DOE Systems Biology Knowledgebase (KBase) ( 7th Annual SFAF Meeting, 2012)

    ScienceCinema

    Brettin, Tom [Oak Ridge National Laboratory

    2013-03-22

    Tom Brettin on "Building the DOE Systems Biology Knowledgebase (KBase)" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.

  3. DOE Systems Biology Knowledgebase (KBASE) (JGI Seventh Annual User Meeting 2012: Genomics of Energy and Environment)

    ScienceCinema

    Arkin, Adam [LBNL

    2016-07-12

    Adam Arkin from Berkeley Lab on the DOE Systems Biology Knowledgebase (KBASE) at the 7th Annual Genomics of Energy & Environment Meeting on March 21, 2012 in Walnut Creek, Calif

  4. DOE Systems Biology Knowledgebase (KBASE) (JGI Seventh Annual User Meeting 2012: Genomics of Energy and Environment)

    SciTech Connect

    Arkin, Adam [LBNL] [LBNL

    2012-03-21

    Adam Arkin from Berkeley Lab on the DOE Systems Biology Knowledgebase (KBASE) at the 7th Annual Genomics of Energy & Environment Meeting on March 21, 2012 in Walnut Creek, Calif

  5. Theoretical Biology and Biophysics

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Theoretical Biology and Biophysics Modeling biological systems and analysis and informatics of molecular and cellular biological data Mathematical BiologyImmunology Fundamental ...

  6. A Systems Biology Approach to Infectious Disease Research: Innovating the Pathogen-Host Research Paradigm

    SciTech Connect

    Aderem, Alan; Adkins, Joshua N.; Ansong, Charles; Galagan, James; Kaiser, Shari; Korth, Marcus J.; Law, G. L.; McDermott, Jason E.; Proll, Sean; Rosenberger, Carrie; Schoolnik, Gary; Katze, Michael G.

    2011-02-01

    The 20th century was marked by extraordinary advances in our understanding of microbes and infectious disease, but pandemics remain, food and water borne illnesses are frequent, multi-drug resistant microbes are on the rise, and the needed drugs and vaccines have not been developed. The scientific approaches of the pastincluding the intense focus on individual genes and proteins typical of molecular biologyhave not been sufficient to address these challenges. The first decade of the 21st century has seen remarkable innovations in technology and computational methods. These new tools provide nearly comprehensive views of complex biological systems and can provide a correspondingly deeper understanding of pathogen-host interactions. To take full advantage of these innovations, the National Institute of Allergy and Infectious Diseases recently initiated the Systems Biology Program for Infectious Disease Research. As participants of the Systems Biology Program we think that the time is at hand to redefine the pathogen-host research paradigm.

  7. Modular Automated Processing System (MAPS) for analysis of biological samples.

    SciTech Connect

    Gil, Geun-Cheol; Chirica, Gabriela S.; Fruetel, Julia A.; VanderNoot, Victoria A.; Branda, Steven S.; Schoeniger, Joseph S.; Throckmorton, Daniel J.; Brennan, James S.; Renzi, Ronald F.

    2010-10-01

    We have developed a novel modular automated processing system (MAPS) that enables reliable, high-throughput analysis as well as sample-customized processing. This system is comprised of a set of independent modules that carry out individual sample processing functions: cell lysis, protein concentration (based on hydrophobic, ion-exchange and affinity interactions), interferent depletion, buffer exchange, and enzymatic digestion of proteins of interest. Taking advantage of its unique capacity for enclosed processing of intact bioparticulates (viruses, spores) and complex serum samples, we have used MAPS for analysis of BSL1 and BSL2 samples to identify specific protein markers through integration with the portable microChemLab{trademark} and MALDI.

  8. System for monitoring an industrial or biological process

    DOEpatents

    Gross, K.C.; Wegerich, S.W.; Vilim, R.B.; White, A.M.

    1998-06-30

    A method and apparatus are disclosed for monitoring and responding to conditions of an industrial process. Industrial process signals, such as repetitive manufacturing, testing and operational machine signals, are generated by a system. Sensor signals characteristic of the process are generated over a time length and compared to reference signals over the time length. The industrial signals are adjusted over the time length relative to the reference signals, the phase shift of the industrial signals is optimized to the reference signals and the resulting signals output for analysis by systems such as SPRT. 49 figs.

  9. System for monitoring an industrial or biological process

    DOEpatents

    Gross, Kenneth C.; Wegerich, Stephan W.; Vilim, Rick B.; White, Andrew M.

    1998-01-01

    A method and apparatus for monitoring and responding to conditions of an industrial process. Industrial process signals, such as repetitive manufacturing, testing and operational machine signals, are generated by a system. Sensor signals characteristic of the process are generated over a time length and compared to reference signals over the time length. The industrial signals are adjusted over the time length relative to the reference signals, the phase shift of the industrial signals is optimized to the reference signals and the resulting signals output for analysis by systems such as SPRT.

  10. Optimiziing the laboratory monitoring of biological wastewater-purification systems

    SciTech Connect

    S.V. Gerasimov

    2009-05-15

    Optimization of the laboratory monitoring of biochemical wastewater-treatment systems at coke plants is considered, for the example of OAO Koks. By adopting a methodological approach to determine the necessary data from chemical analysis, it is possible to reduce the time, labor, and materials required for monitoring, without impairing the purification process or compromising the plant's environmental policies.

  11. Method And System For Examining Biological Materials Using Low Power Cw Excitation Raman Spectroscopy.

    DOEpatents

    Alfano, Robert R.; Wang, Wubao

    2003-05-06

    A method and system for examining biological materials using low-power cw excitation Raman spectroscopy. A low-power continuous wave (cw) pump laser beam and a low-power cw Stokes (or anti-Stokes) probe laser beam simultaneously illuminate a biological material and traverse the biological material in collinearity. The pump beam, whose frequency is varied, is used to induce Raman emission from the biological material. The intensity of the probe beam, whose frequency is kept constant, is monitored as it leaves the biological material. When the difference between the pump and probe excitation frequencies is equal to a Raman vibrational mode frequency of the biological material, the weak probe signal becomes amplified by one or more orders of magnitude (typically up to about 10.sup.4 -10.sup.6) due to the Raman emission from the pump beam. In this manner, by monitoring the intensity of the probe beam emitted from the biological material as the pump beam is varied in frequency, one can obtain an excitation Raman spectrum for the biological material tested. The present invention may be applied to in the in vivo and/or in vitro diagnosis of diabetes, heart disease, hepatitis, cancers and other diseases by measuring the characteristic excitation Raman lines of blood glucose, cholesterol, serum glutamic oxalacetic transaminase (SGOT)/serum glutamic pyruvic transaminase (SGPT), tissues and other corresponding Raman-active body constituents, respectively.

  12. Systems-Level Synthetic Biology for Advanced Biofuel Production

    SciTech Connect

    Ruffing, Anne; Jensen, Travis J.; Strickland, Lucas Marshall; Meserole, Stephen; Tallant, David

    2015-03-01

    Cyanobacteria have been shown to be capable of producing a variety of advanced biofuels; however, product yields remain well below those necessary for large scale production. New genetic tools and high throughput metabolic engineering techniques are needed to optimize cyanobacterial metabolisms for enhanced biofuel production. Towards this goal, this project advances the development of a multiple promoter replacement technique for systems-level optimization of gene expression in a model cyanobacterial host: Synechococcus sp. PCC 7002. To realize this multiple-target approach, key capabilities were developed, including a high throughput detection method for advanced biofuels, enhanced transformation efficiency, and genetic tools for Synechococcus sp. PCC 7002. Moreover, several additional obstacles were identified for realization of this multiple promoter replacement technique. The techniques and tools developed in this project will help to enable future efforts in the advancement of cyanobacterial biofuels.

  13. MIDC: Links

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Links Other Data Collection Activities Baseline Surface Radiation Network (BSRN) Clear Sky Forcast for NREL/SRRL (or other locations) Colorado Dept. of Public Health & Environment: Air Quality Index (AQI) Reporting System Colorado State University: USDA UV-B Monitoring and Research Program European Skynet Radiometers network (ESR) Jefferson County, Colorado: Jeffco Weather Station NOAA: Climate Monitoring & Diagnostics Laboratory (CMDL) NREL OTF: Reference Meteorological and Irradiance

  14. Method And System For Examining Biological Materials Using Low Power Cw Excitation Raman Spectroscopy.

    DOEpatents

    Alfano, Robert R.; Wang, Wubao

    2000-11-21

    A method and system for examining biological materials using low-power cw excitation Raman spectroscopy. In accordance with the teachings of the invention, a low-power continuous wave (cw) pump laser beam and a low-power cw Stokes (or anti-Stokes) probe laser beam simultaneously illuminate a biological material and traverse the biological material in collinearity. The pump beam, whose frequency is varied, is used to induce Raman emission from the biological material. The intensity of the probe beam, whose frequency is kept constant, is monitored as it leaves the biological material. When the difference between the pump and probe excitation frequencies is equal to a Raman vibrational mode frequency of the biological material, the weak probe signal becomes amplified by one or more orders of magnitude (typically up to about 10.sup.4 -10.sup.6) due to the Raman emission from the pump beam. In this manner, by monitoring the intensity of the probe beam emitted from the biological material as the pump beam is varied in frequency, one can obtain an excitation Raman spectrum for the biological material tested. The present invention may be applied to in the in vivo and/or in vitro diagnosis of diabetes, heart disease, hepatitis, cancers and other diseases by measuring the characteristic excitation Raman lines of blood glucose, cholesterol, serum glutamic oxalacetic transaminase (SGOT)/serum glutamic pyruvic tansaminase (SGPT), tissues and other corresponding Raman-active body constituents, respectively. For example, it may also be used to diagnose diseases associated with the concentration of Raman-active constituents in urine, lymph and saliva It may be used to identify cancer in the breast, cervix, uterus, ovaries and the like by measuring the fingerprint excitation Raman spectra of these tissues. It may also be used to reveal the growing of tumors or cancers by measuring the levels of nitric oxide in tissue.

  15. Final report for Conference Support Grant "From Computational Biophysics to Systems Biology - CBSB12"

    SciTech Connect

    Hansmann, Ulrich H.E.

    2012-07-02

    This report summarizes the outcome of the international workshop “From Computational Biophysics to Systems Biology (CBSB12)” which was held June 3-5, 2012, at the University of Tennessee Conference Center in Knoxville, TN, and supported by DOE through the Conference Support Grant 120174. The purpose of CBSB12 was to provide a forum for the interaction between a data-mining interested systems biology community and a simulation and first-principle oriented computational biophysics/biochemistry community. CBSB12 was the sixth in a series of workshops of the same name organized in recent years, and the second that has been held in the USA. As in previous years, it gave researchers from physics, biology, and computer science an opportunity to acquaint each other with current trends in computational biophysics and systems biology, to explore venues of cooperation, and to establish together a detailed understanding of cells at a molecular level. The conference grant of $10,000 was used to cover registration fees and provide travel fellowships to selected students and postdoctoral scientists. By educating graduate students and providing a forum for young scientists to perform research into the working of cells at a molecular level, the workshop adds to DOE's mission of paving the way to exploit the abilities of living systems to capture, store and utilize energy.

  16. Interaction of biological systems with static and ELF electric and magnetic fields

    SciTech Connect

    Anderson, L.E.; Kelman, B.J.; Weigel, R.J.

    1987-01-01

    Although background levels of atmospheric electric and geomagnetic field levels are extremely low, over the past several decades, human beings and other life forms on this planet have been subjected to a dramatically changing electromagnetic milieu. An exponential increase in exposure to electromagnetic fields has occurred, largely because of such technological advances as the growth of electrical power generation and transmission systems, the increased use of wireless communications, and the use of radar. In addition, electromagnetic field generating devices have proliferated in industrial plants, office buildings, homes, public transportation systems, and elsewhere. Although significant increases have occurred in electromagnetic field strenghths spanning all frequency ranges, this symposium addresses only the impact of these fields at static and extremely low frequencies (ELF), primarily 50 and 60 Hz. This volume contains the proceedings of the symposium entitled /open quotes/Interaction of biological systems with static and ELF electric and magnetic fields/close quotes/. The purpose of the symposium was to provide a forum for discussions of all aspects of research on the interaction of static and ELF electromagnetic fields with biological systems. These systems include simple biophysical models, cell and organ preparations, whole animals, and man. Dosimetry, exposure system design, and artifacts in ELF bioeffects research were also addressed, along with current investigations that examine fundamental mechanisms of interactions between the fields and biological processes. Papers are indexed separately.

  17. From systems biology to photosynthesis and whole-plant modeling: a conceptual model for integrating multi-scale networks

    SciTech Connect

    Weston, David; Hanson, Paul J; Norby, Richard J; Tuskan, Gerald A; Wullschleger, Stan D

    2012-01-01

    Network analysis is now a common statistical tool for molecular biologists. Network algorithms are readily used to model gene, protein and metabolic correlations providing insight into pathways driving biological phenomenon. One output from such an analysis is a candidate gene list that can be responsible, in part, for the biological process of interest. The question remains, however, as to whether molecular network analysis can be used to inform process models at higher levels of biological organization. In our previous work, transcriptional networks derived from three plant species were constructed, interrogated for orthology and then correlated to photosynthetic inhibition at elevated temperature. One unique aspect of that study was the link from co-expression networks to net photosynthesis. In this addendum, we propose a conceptual model where traditional network analysis can be linked to whole-plant models thereby informing predictions on key processes such as photosynthesis, nutrient uptake and assimilation, and C partitioning.

  18. Frontiers of Plant Cell Biology: Signals and Pathways, System-Based Approaches 22nd Symposium in Plant Biology (University of California-Riverside)

    SciTech Connect

    Minorsky, Peter V.

    2003-06-01

    The symposium ''Frontiers of Plant Cell Biology: Signals and Pathways, Systems-Based Approaches'' was held January 15-18, 2003 at the Riverside Convention Center in Riverside, California. The host organization for the symposium was the Center for Plant Cell Biology (CEPCEB) at the University of California, Riverside (UCR). The meeting, focusing on systems-based approaches to plant cell biology research, was the first of this kind in the field of plant biology. The speakers and nearly 100 posters placed emphasis on recent developments in plant cellular biology and molecular genetics, particularly those employing emerging genomic tools, thereby sharing the most current knowledge in the field and stimulating future advances. In attendance were many well-established scientists and young investigators who approach plant cell biology from different but complementary conceptual and technical perspectives. Indeed, many disciplines are converging in the field of cell biology, producing synergies that will enable plant scientists to determine the function of gene products in the context of living cells in whole organisms. New, cross-disciplinary collaborations, as well as the involvement of computer scientists and chemists in plant biology research, are likely additional outcomes of the symposium. The program included 39 invited session speakers and workshop/panel speakers. Sessions were convened on the following themes: Cell-Cell Communication; Protein Trafficking; Cell Surface, Extracellular Matrix and Cell Wall; Signal Transduction; Signal Transduction and Proteosome; and Systems-Based Approaches to Plant Cell Biology. Workshops on Chemical Genetics and Visual Microscopy were also presented. Abstracts from each of the speaker presentations, as well as the posters presented at the meeting were published in a program booklet given to the 239 faculty members, researchers, postdoctoral scientists and graduate students in attendance. The booklet thus serves as a reference for

  19. Biological optimization systems for enhancing photosynthetic efficiency and methods of use

    DOEpatents

    Hunt, Ryan W.; Chinnasamy, Senthil; Das, Keshav C.; de Mattos, Erico Rolim

    2012-11-06

    Biological optimization systems for enhancing photosynthetic efficiency and methods of use. Specifically, methods for enhancing photosynthetic efficiency including applying pulsed light to a photosynthetic organism, using a chlorophyll fluorescence feedback control system to determine one or more photosynthetic efficiency parameters, and adjusting one or more of the photosynthetic efficiency parameters to drive the photosynthesis by the delivery of an amount of light to optimize light absorption of the photosynthetic organism while providing enough dark time between light pulses to prevent oversaturation of the chlorophyll reaction centers are disclosed.

  20. HELPFUL LINKS

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Helpful Links HELPFUL LINKS Caution: Many of the links listed below are outside of the DOE Idaho Operations Office, (DOE-ID) Internet site and are not under our control. They have been provided as a convenience to you. DOE-ID is not responsible for the content of linked sites or any link contained in those sites. It is up to the individual user to protect themselves and to take adequate precaution against possible damages resulting from linked sites. Science.gov Communications Page Defense

  1. Meteorological Integration for the Biological Warning and Incident Characterization (BWIC) System: General Guidance for BWIC Cities

    SciTech Connect

    Shaw, William J.; Wang, Weiguo; Rutz, Frederick C.; Chapman, Elaine G.; Rishel, Jeremy P.; Xie, YuLong; Seiple, Timothy E.; Allwine, K Jerry

    2007-02-16

    The U.S. Department of Homeland Security (DHS) is responsible for developing systems to detect the release of aerosolized bioagents in urban environments. The system that accomplishes this, known as BioWatch, is a robust first-generation monitoring system. In conjunction with the BioWatch detection network, DHS has also developed a software tool for cities to use to assist in their response when a bioagent is detected. This tool, the Biological Warning and Incident Characterization (BWIC) System, will eventually be deployed to all BioWatch cities to aid in the interpretation of the public health significance of indicators from the BioWatch networks. BWIC consists of a set of integrated modules, including meteorological models, that estimate the effect of a biological agent on a city’s population once it has been detected. For the meteorological models in BWIC to successfully calculate the distribution of biological material, they must have as input accurate meteorological data, and wind fields in particular. The purpose of this document is to provide guidance for cities to use in identifying sources of good-quality local meteorological data that BWIC needs to function properly. This process of finding sources of local meteorological data, evaluating the data quality and gaps in coverage, and getting the data into BWIC, referred to as meteorological integration, is described. The good news for many cities is that meteorological measurement networks are becoming increasingly common. Most of these networks allow their data to be distributed in real time via the internet. Thus, cities will often only need to evaluate the quality of available measurements and perhaps add a modest number of stations where coverage is poor.

  2. Cool Links

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Cool Links Cool Links Can't get enough science? Click on these links to learn more about science and innovations at the Lab and beyond! Science and learning activities Los Alamos National Laboratory links Bradbury Science Museum video The Town That Never Was Bradbury Science Museum video Heritage of Science (Stockpile Stewardship) Los Alamos National Laboratory Homepage A list of Los Alamos National Laboratory publications Los Alamos National Laboratory's periodic table website Los Alamos

  3. Methodology for integration of HVDC links in large ac systems. Phase I. Reference manual. Final report

    SciTech Connect

    Meredith, R.J.

    1983-03-01

    HVDC transmission has been found to be an attractive alternative to ac transmission in many situations. Evaluations of HVDC alternatives include technical, economic, environmental and sometimes regulatory considerations which are different than those for ac transmission. This research project resulted in the preparation of a HVDC reference manual which describes a comprehensive methodology for evaluating HVDC alternatives in utility transmission planning. It provides basic background information about existing HVDC systems. It describes the types of studies required and potential problems which must be dealt with. It also discusses how the studies are usually run and what system modeling is required. It emphasizes the importance of proper control of the dc system and provides examples of control systems which have been used.

  4. Assessment of disinfectants in explosive destruction system for biological agent destruction : LDRD final report FY04.

    SciTech Connect

    Simmons, Blake Alexander; Didlake, John E. Jr.; Bradshaw, Robert W.; Crooker, Paul J.; Buffleben, George M.

    2005-01-01

    Treatment systems that can neutralize biological agents are needed to mitigate risks from novel and legacy biohazards. Tests with Bacillus thuringiensis and Bacillus steurothemophilus spores were performed in a 190-liter, 1-112 lb TNT equivalent rated Explosive Destruction System (EDS) system to evaluate its capability to treat and destroy biological agents. Five tests were conducted using three different agents to kill the spores. The EDS was operated in steam autoclave, gas fumigation and liquid decontamination modes. The first three tests used EDS as an autoclave, which uses pressurized steam to kill the spores. Autoclaving was performed at 130-140 deg C for up to 2-hours. Tests with chlorine dioxide at 750 ppm concentration for 1 hour and 10% (vol) aqueous chlorine bleach solution for 1 hour were also performed. All tests resulted in complete neutralization of the bacterial spores based on no bacterial growth in post-treatment incubations. Explosively opening a glass container to expose the bacterial spores for treatment with steam was demonstrated and could easily be done for chlorine dioxide gas or liquid bleach.

  5. Synthetic Biology and the U.S. Biotechnology Regulatory System: Challenges and Options

    SciTech Connect

    Carter, Sarah R.; Rodemeyer, Michael; Garfinkel, Michele S.; Friedman, Robert M

    2014-05-01

    Synthetic Biology and the U.S. Biotechnology Regulatory System: Challenges and Options Sarah R. Carter, Ph.D., J. Craig Venter Institute; Michael Rodemeyer, J.D., University of Virginia; Michele S. Garfinkel, Ph.D., EMBO; Robert M. Friedman, Ph.D., J. Craig Venter Institute In recent years, a range of genetic engineering techniques referred to as “synthetic biology” has significantly expanded the tool kit available to scientists and engineers, providing them with far greater capabilities to engineer organisms than previous techniques allowed. The field of synthetic biology includes the relatively new ability to synthesize long pieces of DNA from chemicals, as well as improved methods for genetic manipulation and design of genetic pathways to achieve more precise control of biological systems. These advances will help usher in a new generation of genetically engineered microbes, plants, and animals. The JCVI Policy Center team, along with researchers at the University of Virginia and EMBO, examined how well the current U.S. regulatory system for genetically engineered products will handle the near-term introduction of organisms engineered using synthetic biology. In particular, the focus was on those organisms intended to be used or grown directly in the environment, outside of a contained facility. The study concludes that the U.S. regulatory agencies have adequate legal authority to address most, but not all, potential environmental, health and safety concerns posed by these organisms. Such near-term products are likely to represent incremental changes rather than a marked departure from previous genetically engineered organisms. However, the study also identified two key challenges for the regulatory system, which are detailed in the report. First, USDA’s authority over genetically engineered plants depends on the use of an older engineering technique that is no longer necessary for many applications. The shift to synthetic biology and other newer genetic

  6. A Fish-eye View of Riverine Hydropower Systems: Understanding the Biological Response to Turbine Passage

    SciTech Connect

    Pracheil, Brenda M; DeRolph, Christopher R; Schramm, Michael P; Bevelhimer, Mark S

    2016-01-01

    Fish populations that have been traditionally thought of as completely fragmented by dams still maintain limited, one-way connectivity from upstream to downstream reaches via downstream turbine passage. This one-way connectivity may be important to population dynamics, but can also introduce a new and significant source of mortality due to turbine-induced fish injury and mortality. Mechanistically, fish injury and mortality associated with downstream turbine passage can come from several sources including blade strike, shear forces, cavitation, or pressure decreases, and parsing the contributions of these individual forces is important for advancing and deploying turbines that minimize these impacts to fishes. The overarching goals of this project are two-fold: 1. To inform biological limitations of fish for use in creating and testing advanced turbine designs (e.g., research and development) and 2. To provide insight into locations that would be good initial locations for deploying advanced turbines (e.g., marketing). This report is an initial step in linking physical forces to injury and mortality rates to provide a better understanding turbine-associated injury and mortality rates for turbine designers and manufacturers and examine the spatial distribution of hydropower, turbines, and fishes across the U.S.A. to determine locations that may be good candidates for advanced turbine designs. We also use this report to present an initial approach for selecting species for further laboratory and field studies that examine the impacts of hydropower on fishes.

  7. A NEW ACCRETION DISK AROUND THE MISSING LINK BINARY SYSTEM PSR J1023+0038

    SciTech Connect

    Patruno, A.; Archibald, A. M.; Hessels, J. W. T.; Bassa, C. G.; Janssen, G. H.; Bogdanov, S.; Stappers, B. W.; Lyne, A. G.; Kaspi, V. M.; Tendulkar, S.

    2014-01-20

    PSR J1023+0038 is an exceptional system for understanding how slowly rotating neutron stars are spun up to millisecond rotational periods through accretion from a companion star. Observed as a radio pulsar from 2007-2013, optical data showed that the system had an accretion disk in 2000/2001. Starting at the end of 2013 June, the radio pulsar has become undetectable, suggesting a return to the previous accretion-disk state, where the system more closely resembles an X-ray binary. In this Letter we report the first targeted X-ray observations ever performed of the active phase and complement them with UV/optical and radio observations collected in 2013 October. We find strong evidence that indeed an accretion disk has recently formed in the system and we report the detection of fast X-ray changes spanning about two orders of magnitude in luminosity. No radio pulsations are seen during low flux states in the X-ray light curve or at any other times.

  8. DANDE: a linked code system for core neutronics/depletion analysis

    SciTech Connect

    LaBauve, R.J.; England, T.R.; George, D.C.; MacFarlane, R.E.; Wilson, W.B.

    1985-06-01

    This report describes DANDE - a modular neutronics, depletion code system for reactor analysis. It consists of nuclear data processing, core physics, and fuel depletion modules, and allows one to use diffusion and transport methods interchangeably in core neutronics calculations. This latter capability is especially important in the design of small modular cores. Additional unique features include the capability of updating the nuclear data file during a calculation; a detailed treatment of depletion, burnable poisons as well as fuel; and the ability to make geometric changes such as control rod repositioning and fuel relocation in the course of a calculation. The detailed treatment of reactor fuel burnup, fission-product creation and decay, as well as inventories of higher-order actinides is a necessity when predicting the behavior of reactor fuel under increased burn conditions. The operation of the code system is made clear in this report by following a sample problem.

  9. Fast prediction of transient stability margin in systems with SVC control and HVDC link

    SciTech Connect

    Tso, S.K.; Cheung, S.P.

    1995-12-31

    Recent developments in transient stability margin (TSM) prediction using the energy-based direct method have included excitation controllers, power system stabilizers (PSSs) and/or static VAr compensators (SVCs). These devices can be represented in their detailed dynamic models to desired degrees of complexity while the proposed extended equal-area criterion can still be effectively applied. This paper describes further development of this technique to incorporate an HVDC transmission into the test network for TSM prediction. The method is examined with a practical 17-machine power network representing the South China/Hong Kong system. An SVC control scheme is also installed in a weak bus of the test network for transient stability improvement. The results obtained show that there is no sacrifice in accuracy, speed or reliability of the TSM method with SVC and HVDC realistically incorporated into the study.

  10. Controlling harmonic instability of HVDC links connected to weak ac systems

    SciTech Connect

    Bodger, P.S. ); Irwin, G.D.; Woodford, D.A. )

    1990-10-01

    Time domain digital simulation of HVDC transmission enables harmonic stability of a system to be studied. This paper reports two alternative measures of controlling harmonic instability were investigated; the use of C-type ac filters and a simple addition of a harmonic damping circuit in the rectifier converter control. The design of a C-type filter is described and its effectiveness presented. Harmonic damping by controls consists of taking the output from a fast response dc current transducer, passing it through a filter and a gain and adding the output to the firing angle order. Both methods result in stable recovery from faults at both rectifier and inverter terminal busbars for a dc system inherently harmonically unstable.

  11. Final Report - Phylogenomic tools and web resources for the Systems Biology Knowledgebase

    SciTech Connect

    Sjolander, Kimmen

    2014-11-07

    The major advance during this last reporting period (8/15/12 to present) is our release of data on the PhyloFacts website: phylogenetic trees, multiple sequence alignments and other data for protein families are now available for download from http://phylogenomics.berkeley.edu/data/. This project as a whole aimed to develop high-throughput functional annotation systems that exploit information from protein 3D structure and evolution to provide highly precise inferences of various aspects of gene function, including molecular function, biological process, pathway association, Pfam domains, cellular localization and so on. We accomplished these aims by developing and testing different systems on a database of protein family trees: the PhyloFacts Phylogenomic Encyclopedia (at http://phylogenomics.berkeley.edu/phylofacts/ ).

  12. Towards Composing Data Aware Systems Biology Workflows on Cloud Platforms: A MeDICi-based Approach

    SciTech Connect

    Gorton, Ian; Liu, Yan; Yin, Jian; Kulkarni, Anand V.; Wynne, Adam S.

    2011-09-08

    Cloud computing is being increasingly adopted for deploying systems biology scientific workflows. Scientists developing these workflows use a wide variety of fragmented and competing data sets and computational tools of all scales to support their research. To this end, the synergy of client side workflow tools with cloud platforms is a promising approach to share and reuse data and workflows. In such systems, the location of data and computation is essential consideration in terms of quality of service for composing a scientific workflow across remote cloud platforms. In this paper, we describe a cloud-based workflow for genome annotation processing that is underpinned by MeDICi - a middleware designed for data intensive scientific applications. The workflow implementation incorporates an execution layer for exploiting data locality that routes the workflow requests to the processing steps that are colocated with the data. We demonstrate our approach by composing two workflowswith the MeDICi pipelines.

  13. How sulphate-reducing microorganisms cope with stress: Lessons from systems biology

    SciTech Connect

    Zhou, J.; He, Q.; Hemme, C.L.; Mukhopadhyay, A.; Hillesland, K.; Zhou, A.; He, Z.; Nostrand, J.D. Van; Hazen, T.C.; Stahl, D.A.; Wall, J.D.; Arkin, A.P.

    2011-04-01

    Sulphate-reducing microorganisms (SRMs) are a phylogenetically diverse group of anaerobes encompassing distinct physiologies with a broad ecological distribution. As SRMs have important roles in the biogeochemical cycling of carbon, nitrogen, sulphur and various metals, an understanding of how these organisms respond to environmental stresses is of fundamental and practical importance. In this Review, we highlight recent applications of systems biology tools in studying the stress responses of SRMs, particularly Desulfovibrio spp., at the cell, population, community and ecosystem levels. The syntrophic lifestyle of SRMs is also discussed, with a focus on system-level analyses of adaptive mechanisms. Such information is important for understanding the microbiology of the global sulphur cycle and for developing biotechnological applications of SRMs for environmental remediation, energy production, biocorrosion control, wastewater treatment and mineral recovery.

  14. Links - SRSCRO

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Links Links Links Surplus Equipment Bolin Marketing Group | www.bmgsurplus.com Counties of the SRSCRO Region Aiken County | www.aikencounty.net Allendale County | www.allendalecounty.com Barnwell County | www.barnwellcounty.sc.gov Columbia County | www.columbiacountyga.gov Richmond County | www.augustaga.gov Chambers of Commerce Aiken SC | www.aikenchamber.net Augusta, GA | www.augustagausa.com Barnwell, SC | www.barnwellcountychamber.org Columbia County, GA | www.columbiacountychamber.com North

  15. External Links

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    External Links External Links This page contains links to web sites and pages having to do with the Federal Energy Technology Network, Department of Energy, and Energy related Internet resources. The information is divided into the following categories: Table of Contents Department of Energy Support Offices Within the Department of Energy Office of Small & Disadvantaged Business Utilization (OSDBU) General Information Sources about Government Non-Government Energy and Environmental Related

  16. Ultrashort pulse high repetition rate laser system for biological tissue processing

    DOEpatents

    Neev, J.; Da Silva, L.B.; Matthews, D.L.; Glinsky, M.E.; Stuart, B.C.; Perry, M.D.; Feit, M.D.; Rubenchik, A.M.

    1998-02-24

    A method and apparatus are disclosed for fast, efficient, precise and damage-free biological tissue removal using an ultrashort pulse duration laser system operating at high pulse repetition rates. The duration of each laser pulse is on the order of about 1 fs to less than 50 ps such that energy deposition is localized in a small depth and occurs before significant hydrodynamic motion and thermal conduction, leading to collateral damage, can take place. The depth of material removed per pulse is on the order of about 1 micrometer, and the minimal thermal and mechanical effects associated with this ablation method allows for high repetition rate operation, in the region 10 to over 1000 Hertz, which, in turn, achieves high material removal rates. The input laser energy per ablated volume of tissue is small, and the energy density required to ablate material decreases with decreasing pulse width. The ablation threshold and ablation rate are only weakly dependent on tissue type and condition, allowing for maximum flexibility of use in various biological tissue removal applications. The use of a chirped-pulse amplified Titanium-doped sapphire laser is disclosed as the source in one embodiment. 8 figs.

  17. Ultrashort pulse high repetition rate laser system for biological tissue processing

    DOEpatents

    Neev, Joseph; Da Silva, Luiz B.; Matthews, Dennis L.; Glinsky, Michael E.; Stuart, Brent C.; Perry, Michael D.; Feit, Michael D.; Rubenchik, Alexander M.

    1998-01-01

    A method and apparatus is disclosed for fast, efficient, precise and damage-free biological tissue removal using an ultrashort pulse duration laser system operating at high pulse repetition rates. The duration of each laser pulse is on the order of about 1 fs to less than 50 ps such that energy deposition is localized in a small depth and occurs before significant hydrodynamic motion and thermal conduction, leading to collateral damage, can take place. The depth of material removed per pulse is on the order of about 1 micrometer, and the minimal thermal and mechanical effects associated with this ablation method allows for high repetition rate operation, in the region 10 to over 1000 Hertz, which, in turn, achieves high material removal rates. The input laser energy per ablated volume of tissue is small, and the energy density required to ablate material decreases with decreasing pulse width. The ablation threshold and ablation rate are only weakly dependent on tissue type and condition, allowing for maximum flexibility of use in various biological tissue removal applications. The use of a chirped-pulse amplified Titanium-doped sapphire laser is disclosed as the source in one embodiment.

  18. On linking an Earth system model to the equilibrium carbon representation of an economically optimizing land use model

    SciTech Connect

    Bond-Lamberty, Benjamin; Calvin, Katherine V.; Jones, Andrew D.; Mao, Jiafu; Patel, Pralit L.; Shi, Xiaoying; Thomson, Allison M.; Thornton, Peter E.; Zhou, Yuyu

    2014-01-01

    Human activities are significantly altering biogeochemical cycles at the global scale, posing a significant problem for earth system models (ESMs), which may incorporate static land-use change inputs but do not actively simulate policy or economic forces. One option to address this problem is a to couple an ESM with an economically oriented integrated assessment model. Here we have implemented and tested a coupling mechanism between the carbon cycles of an ESM (CLM) and an integrated assessment (GCAM) model, examining the best proxy variables to share between the models, and quantifying our ability to distinguish climate- and land-use-driven flux changes. CLMs net primary production and heterotrophic respiration outputs were found to be the most robust proxy variables by which to manipulate GCAMs assumptions of long-term ecosystem steady state carbon, with short-term forest production strongly correlated with long-term biomass changes in climate-change model runs. By leveraging the fact that carbon-cycle effects of anthropogenic land-use change are short-term and spatially limited relative to widely distributed climate effects, we were able to distinguish these effects successfully in the model coupling, passing only the latter to GCAM. By allowing climate effects from a full earth system model to dynamically modulate the economic and policy decisions of an integrated assessment model, this work provides a foundation for linking these models in a robust and flexible framework capable of examining two-way interactions between human and earth system processes.

  19. Designing Biological Systems for Sustainability and Programmed Environmental Interface (2011 JGI User Meeting)

    ScienceCinema

    Silver, Pam [Harvard University

    2016-07-12

    The U.S. Department of Energy Joint Genome Institute (JGI) invited scientists interested in the application of genomics to bioenergy and environmental issues, as well as all current and prospective users and collaborators, to attend the annual DOE JGI Genomics of Energy & Environment Meeting held March 22-24, 2011 in Walnut Creek, Calif. The emphasis of this meeting was on the genomics of renewable energy strategies, carbon cycling, environmental gene discovery, and engineering of fuel-producing organisms. The meeting features presentations by leading scientists advancing these topics. Pam Silver of Harvard University gives a presentation on "Designing Biological Systems for Sustainability and Programmed Environmental Interface" at the 6th annual Genomics of Energy & Environment Meeting on March 23, 2011

  20. Designing Biological Systems for Sustainability and Programmed Environmental Interface (2011 JGI User Meeting)

    SciTech Connect

    Silver, Pam [Harvard University] [Harvard University

    2011-03-23

    The U.S. Department of Energy Joint Genome Institute (JGI) invited scientists interested in the application of genomics to bioenergy and environmental issues, as well as all current and prospective users and collaborators, to attend the annual DOE JGI Genomics of Energy & Environment Meeting held March 22-24, 2011 in Walnut Creek, Calif. The emphasis of this meeting was on the genomics of renewable energy strategies, carbon cycling, environmental gene discovery, and engineering of fuel-producing organisms. The meeting features presentations by leading scientists advancing these topics. Pam Silver of Harvard University gives a presentation on "Designing Biological Systems for Sustainability and Programmed Environmental Interface" at the 6th annual Genomics of Energy & Environment Meeting on March 23, 2011

  1. Systems biology analysis of Zymomonas mobilis ZM4 ethanol stress responses

    SciTech Connect

    Yang, Shihui; Pan, Chongle; Tschaplinski, Timothy J; Hurst, Gregory {Greg} B; Engle, Nancy L; Zhou, Wen; Dam, Phuongan; Xu, Ying; Dice, Lezlee T; Davison, Brian H; Brown, Steven D

    2013-01-01

    Zymomonas mobilis ZM4 is a capable ethanogenic bacterium with high ethanol productivity and high level of ethanol tolerance. Previous studies indicated that several stress-related proteins and changes in the ZM4 membrane lipid composition may contribute to ethanol tolerance. However, the molecular mechanisms of ethanol stress response have not been elucidated fully. In this study, ethanol stress responses were investigated using systems biology tools. Medium supplementation with an initial 47.3 g/L (6% v/v) ethanol reduced Z. mobilis ZM4 glucose consumption, growth rate and ethanol productivity compared to that of untreated controls. Metabolomic profiling showed that ethanol-treated ZM4 cells accumulated greater amounts of glycerol during the entire fermentation process, which may indicate an important role for this metabolite. A proteomic analysis of early exponential growth identified about one thousand proteins, or approximately 56% of the predicted ZM4 proteome. Proteins related to metabolism and stress response such as chaperones and key regulators were more abundant in the early ethanol stress condition. Transcriptomic studies indicated the response of ZM4 to ethanol is dynamic, complex and involves many genes from all the different functional categories. There were fewer genes significantly differentially expressed in the exponential phase compared to that of stationary phase and early stationary phase. Most down-regulated genes were related to translation and ribosome biogenesis, while the ethanol-upregulated genes were mostly related to cellular processes and metabolism. Correlations among the transcriptomics, proteomics and metabolism were examined and among significantly expressed genes or proteins, we observe higher correlation coefficients when fold-change values are higher. This systems biology study elucidates key Z. mobilis ZM4 metabolites, genes and proteins that form the foundation of its distinctive physiology and its multifaceted response to

  2. A comprehensive collection of systems biology data characterizing the host response to viral infection

    SciTech Connect

    Aevermann, Brian D.; Pickett, Brett E.; Kumar, Sanjeev; Klem, Edward B.; Agnihothram, Sudhakar; Askovich, Peter S.; Bankhead, Armand; Bolles, Meagan; Carter, Victoria; Chang, Jean H.; Clauss, Therese R. W.; Dash, Pradyot; Diercks, Alan H.; Eisfeld, Amie J.; Ellis, Amy L.; Fan, Shufang; Ferris, Martin T.; Gralinski, Lisa; Green, Richard; Gritsenko, Marina A.; Hatta, Masato; Heegel, Robert A.; Jacobs, Jon M.; Jeng, Sophia; Josset, Laurence; Kaiser, Shari M.; Kelly, Sarah; Law, Gale Lynn; Li, Chengjun; Li, Jiangning; Long, Casey; Luna, Maria L.; Matzke, Melissa M.; McDermott, Jason E.; Menachery, Vineet; Metz, Thomas O.; Mitchell, Hugh D.; Monroe, Matthew E.; Navarro, Garnet; Neumann, Gabriele; Podyminogin, Rebecca L.; Purvine, Samuel O.; Rosenberger, Carrie; Sanders, Catherine J.; Schepmoes, Athena A.; Shukla, Anil K.; Sims, Amy; Sova, Pavel; Tam, Vincent C.; Tchitchek, Nicholas; Thomas, Paul G.; Tilton, Susan C.; Totura, Allison L.; Wang, Jing; Webb-Robertson, Bobbie-Jo M.; Wen, Ji; Weiss, Jeffrey M.; Yang, Feng; Yount, Boyd; Zhang, Qibin; Mcweeney, Shannon K.; Smith, Richard D.; Waters, Katrina M.; Kawaoka, Yoshihiro; Baric, Ralph; Aderem, Alan; Katze, Michael G.; Scheuermann, Richard H.

    2014-10-14

    The Systems Biology for Infectious Diseases Research program was established by the U.S. National Institute of Allergy and Infectious Diseases to investigate host-pathogen interactions at a systems level. This program generated 47 transcriptomic and proteomic datasets from 30 studies that investigate in vivo and in vitro host responses to viral infections. Human pathogens in the Orthomyxoviridae and Coronaviridae families, especially pandemic H1N1 and avian H5N1 influenza A viruses and severe acute respiratory syndrome coronavirus (SARS-CoV), were investigated. Study validation was demonstrated via experimental quality control measures and meta-analysis of independent experiments performed under similar conditions. Primary assay results are archived at the GEO and PeptideAtlas public repositories, while processed statistical results together with standardized metadata are publically available at the Influenza Research Database (www.fludb.org) and the Virus Pathogen Resource (www.viprbrc.org). As a result, by comparing data from mutant versus wild-type virus and host strains, RNA versus protein differential expression, and infection with genetically similar strains, these data can be used to further investigate genetic and physiological determinants of host responses to viral infection.

  3. A comprehensive collection of systems biology data characterizing the host response to viral infection

    DOE PAGES [OSTI]

    Aevermann, Brian D.; Pickett, Brett E.; Kumar, Sanjeev; Klem, Edward B.; Agnihothram, Sudhakar; Askovich, Peter S.; Bankhead, Armand; Bolles, Meagan; Carter, Victoria; Chang, Jean H.; et al

    2014-10-14

    The Systems Biology for Infectious Diseases Research program was established by the U.S. National Institute of Allergy and Infectious Diseases to investigate host-pathogen interactions at a systems level. This program generated 47 transcriptomic and proteomic datasets from 30 studies that investigate in vivo and in vitro host responses to viral infections. Human pathogens in the Orthomyxoviridae and Coronaviridae families, especially pandemic H1N1 and avian H5N1 influenza A viruses and severe acute respiratory syndrome coronavirus (SARS-CoV), were investigated. Study validation was demonstrated via experimental quality control measures and meta-analysis of independent experiments performed under similar conditions. Primary assay results are archivedmore » at the GEO and PeptideAtlas public repositories, while processed statistical results together with standardized metadata are publically available at the Influenza Research Database (www.fludb.org) and the Virus Pathogen Resource (www.viprbrc.org). As a result, by comparing data from mutant versus wild-type virus and host strains, RNA versus protein differential expression, and infection with genetically similar strains, these data can be used to further investigate genetic and physiological determinants of host responses to viral infection.« less

  4. New wholesale power market design using linked forward markets : a study for the DOE energy storage systems program.

    SciTech Connect

    Silva Monroy, Cesar Augusto; Loose, Verne William; Ellison, James F.; Elliott, Ryan Thomas; Byrne, Raymond Harry; Guttromson, Ross; Tesfatsion, Leigh S.

    2013-04-01

    This report proposes a reformulation of U.S. ISO/RTO-managed wholesale electric power mar- kets for improved reliability and e ciency of system operations. Current markets do not specify or compensate primary frequency response. They also unnecessarily limit the participation of new technologies in reserve markets and o er insu cient economic inducements for new capacity invest- ment. In the proposed market reformulation, energy products are represented as physically-covered rm contracts and reserve products as physically-covered call option contracts. Trading of these products is supported by a backbone of linked ISO/RTO-managed forward markets with planning horizons ranging from multiple years to minutes ahead. A principal advantage of this reformulation is that reserve needs can be speci ed in detail, and resources can o er the services for which they are best suited, without being forced to conform to rigid reserve product de nitions. This should improve the business case for electric energy storage and other emerging technologies to provide reserve. In addition, the facilitation of price discovery should help to ensure e cient energy/reserve procurement and adequate levels of new capacity investment.

  5. System and method for preconcentrating, identifying, and quantifying chemical and biological substances

    DOEpatents

    Yu, Conrad M. (Antioch, CA); Koo, Jackson C. (San Ramon, CA)

    2000-01-01

    A system and method for preconcentrating, identifying, and quantifying chemical and biological substances is disclosed. An input valve directs a first volume of a sample gas to a surface acoustic wave (SAW) device. The SAW device preconcentrates and detects a mass of a substance within the sample gas. An output valve receives a second volume of the sample gas containing the preconcentrated substance from the SAW device and directs the second volume to a gas chromatograph (GC). The GC identifies the preconcentrated substance within the sample gas. A shunt valve exhausts a volume of the sample gas equal to the first volume minus the second volume away from the SAW device and the GC. The method of the present invention includes the steps of opening an input valve for passing a first volume of a sample gas to a SAW device; preconcentrating and detecting a mass of a substance within the sample gas using the SAW device; opening an output valve for passing a second volume of the sample gas containing the preconcentrated substance to a gas chromatograph (GC); and then identifying the preconcentrated substance within the sample gas using the GC.

  6. Department of Energy's Biological and Environmental Research Strategic Data Roadmap for Earth System Science

    SciTech Connect

    Williams, Dean N.; Palanisamy, Giri; Shipman, Galen; Boden, Thomas A.; Voyles, Jimmy W.

    2014-04-25

    Rapid advances in experimental, sensor, and computational technologies and techniques are driving exponential growth in the volume, acquisition rate, variety, and complexity of scientific data. This wealth of scientifically meaningful data has tremendous potential to lead to scientific discovery. However, to achieve scientific breakthroughs, these data must be exploitable—they must be analyzed effectively and efficiently and the results shared and communicated easily within the wider Department of Energy’s (DOE’s) Biological and Environmental Research (BER) Climate and Environmental Sciences Division (CESD) community. The explosion in data complexity and scale makes these tasks exceedingly difficult to achieve, particularly given that an increasing number of disciplines are working across techniques, integrating simulation and experimental or observational results (see Table 5 in Appendix 2). Consequently, we need new approaches to data management, analysis, and visualization that provide research teams with easy-to-use and scalable end-to-end solutions. These solutions must facilitate (and where feasible, automate and capture) every stage in the data lifecycle (shown in Figure 1), from collection to management, annotation, sharing, discovery, analysis, and visualization. In addition, the core functionalities are the same across climate science communities, but they require customization to adapt to specific needs and fit into research and analysis workflows. To this end, the mission of CESD’s Data and Informatics Program is to integrate all existing and future distributed CESD data holdings into a seamless and unified environment for the acceleration of Earth system science.

  7. Methods and systems for carrying out a pH-influenced chemical and/or biological reaction

    DOEpatents

    Stern, Michael C.; Simeon, Fritz; Hatton, Trevor Alan

    2016-04-05

    The present invention generally relates to methods and systems for carrying out a pH-influenced chemical and/or biological reaction. In some embodiments, the pH-influenced reaction involves the conversion of CO.sub.2 to a dissolved species.

  8. Chemical and biological warfare: Detection and warning systems. (Latest citations from the NTIS bibliographic database). Published Search

    SciTech Connect

    1995-03-01

    The bibliography contains citations concerning the detection, identification, verification, and warning systems of chemical and biological warfare agents. Citations discuss agents sampling, monitoring, and assessment. Techniques include chromotography, biosensing, chemical analysis, and DNA probes. Land pollution, soil tests, and skin protection are examined. (Contains a minimum of 244 citations and includes a subject term index and title list.)

  9. Chemical and biological warfare: Detection and warning systems. (Latest citations from the NTIS bibliographic database). Published Search

    SciTech Connect

    1996-10-01

    The bibliography contains citations concerning the detection, identification, verification, and warning systems of chemical and biological warfare agents. Citations discuss agents sampling, monitoring, and assessment. Techniques include chromotography, biosensing, chemical analysis, and DNA probes. Land pollution, soil tests, and skin protection are examined. (Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

  10. Experimental Systems-Biology Approaches for Clostridia-Based Bioenergy Production

    SciTech Connect

    Papoutsakis, Elefterios

    2015-04-30

    This is the final project report for project "Experimental Systems-Biology Approaches for Clostridia-Based Bioenergy Production" for the funding period of 9/1/12 to 2/28/2015 (three years with a 6-month no-cost extension) OVERVIEW AND PROJECT GOALS The bottleneck of achieving higher rates and titers of toxic metabolites (such as solvents and carboxylic acids that can used as biofuels or biofuel precursors) can be overcome by engineering the stress response system. Thus, understanding and modeling the response of cells to toxic metabolites is a problem of great fundamental and practical significance. In this project, our goal is to dissect at the molecular systems level and build models (conceptual and quantitative) for the stress response of C. acetobutylicum (Cac) to its two toxic metabolites: butanol (BuOH) and butyrate (BA). Transcriptional (RNAseq and microarray based), proteomic and fluxomic data and their analysis are key requirements for this goal. Transcriptional data from mid-exponential cultures of Cac under 4 different levels of BuOH and BA stress was obtained using both microarrays (Papoutsakis group) and deep sequencing (RNAseq; Meyers and Papoutsakis groups). These two sets of data do not only serve to validate each other, but are also used for identification of stress-induced changes in transcript levels, small regulatory RNAs, & in transcriptional start sites. Quantitative proteomic data (Lee group), collected using the iTRAQ technology, are essential for understanding of protein levels and turnover under stress and the various protein-protein interactions that orchestrate the stress response. Metabolic flux changes (Antoniewicz group) of core pathways, which provide important information on the re-allocation of energy and carbon resources under metabolite stress, were examined using 13C-labelled chemicals. Omics data are integrated at different levels and scales. At the metabolic-pathway level, omics data are integrated into a 2nd generation genome

  11. Method and apparatus for routing data in an inter-nodal communications lattice of a massively parallel computer system by dynamic global mapping of contended links

    DOEpatents

    Archer, Charles Jens; Musselman, Roy Glenn; Peters, Amanda; Pinnow, Kurt Walter; Swartz, Brent Allen; Wallenfelt, Brian Paul

    2011-10-04

    A massively parallel nodal computer system periodically collects and broadcasts usage data for an internal communications network. A node sending data over the network makes a global routing determination using the network usage data. Preferably, network usage data comprises an N-bit usage value for each output buffer associated with a network link. An optimum routing is determined by summing the N-bit values associated with each link through which a data packet must pass, and comparing the sums associated with different possible routes.

  12. Links - MST - UW Plasma Physics

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Links UW Madison Madison Symmetric Torus Links MST HomeGraduate Student InformationLinksTourControl and Auxiliary SystemsPhysics TopicsDeviceResearch MissionMST People mst logo CPLA Home Directory Publications Links Internal University of Wisconsin Physics Department Research funding includes support from: Department of Energy National Science Foundation Other Reversed Field Pinch Experiments around the world: RFX-mod in Padua, Italy Extrap-T2R in Stockhom, Sweden RELAX at Kyoto Institute of

  13. Reducing Mortality from Terrorist Releases of Chemical and Biological Agents: I. Filtration for Ventilation Systems in Commercial Building

    SciTech Connect

    Thatcher, Tracy L.; Daisey, Joan M.

    1999-09-01

    There is growing concern about potential terrorist attacks involving releases of chemical and/or biological (CB) agents, such as sarin or anthrax, in and around buildings. For an external release, the CB agent can enter the building through the air intakes of a building's mechanical ventilation system and by infiltration through the building envelope. For an interior release in a single room, the mechanical ventilation system, which often recirculates some fraction of the air within a building, may distribute the released CB agent throughout the building. For both cases, installing building systems that remove chemical and biological agents may be the most effective way to protect building occupants. Filtration systems installed in the heating, ventilating and air-conditioning (HVAC) systems of buildings can significantly reduce exposures of building occupants in the event of a release, whether the release is outdoors or indoors. Reduced exposures can reduce the number of deaths from a terrorist attack. The purpose of this report is to provide information and examples of the design of filtration systems to help building engineers retrofit HVAC systems. The report also provides background information on the physical nature of CB agents and brief overviews of the basic principles of particle and vapor filtration.

  14. (Biological dosimetry)

    SciTech Connect

    Sega, G.A.

    1990-11-06

    The traveler participated in an International Symposium on Trends in Biological Dosimetry and presented an invited paper entitled, Adducts in sperm protamine and DNA vs mutation frequency.'' The purpose of the Symposium was to examine the applicability of new methods to study quantitatively the effects of xenobiotic agents (radiation and chemicals) on molecular, cellular and organ systems, with special emphasis on human biological dosimetry. The general areas covered at the meeting included studies on parent compounds and metabolites; protein adducts; DNA adducts; gene mutations; cytogenetic end-points and reproductive methods.

  15. Biosafety Links | Argonne National Laboratory

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Biosafety Links Animals in Research Autoclave Safety Bacterial Strains Biological Safety Cabinets Biosafety Levels and Checklists Biosafety Levels of Specific Agents Bloodborne Pathogens Bloodborne Pathogen Training CDC-NIH Biosafety Guidelines CDC-NIH Recombinant DNA Guidelines Cell Culture Containment Facilities Disinfection Human Subjects Issues Importation Permits for Etiologic Agents Infectious Agents Microwave Safety MSDSs for Infectious Substances Organizations Prions Recombinant DNA

  16. Biological Effects of Ionizing Radiation

    DOE R&D Accomplishments

    Ingram, M.; Mason, W. B.; Whipple, G. H.; Howland, J. W.

    1952-04-07

    This report presents a review of present knowledge and concepts of the biological effects of ionizing radiations. Among the topics discussed are the physical and chemical effects of ionizing radiation on biological systems, morphological and physiological changes observed in biological systems subjected to ionizing radiations, physiological changes in the intact animal, latent changes following exposure of biological systems to ionizing radiations, factors influencing the biological response to ionizing radiation, relative effects of various ionizing radiations, and biological dosimetry.

  17. Protective link for superconducting coil

    DOEpatents

    Umans, Stephen D.

    2009-12-08

    A superconducting coil system includes a superconducting coil and a protective link of superconducting material coupled to the superconducting coil. A rotating machine includes first and second coils and a protective link of superconducting material. The second coil is operable to rotate with respect to the first coil. One of the first and second coils is a superconducting coil. The protective link is coupled to the superconducting coil.

  18. Enabling X-ray free electron laser crystallography for challenging biological systems from a limited number of crystals

    SciTech Connect

    Uervirojnangkoorn, Monarin; Zeldin, Oliver B.; Lyubimov, Artem Y.; Hattne, Johan; Brewster, Aaron S.; Sauter, Nicholas K.; Brunger, Axel T.; Weis, William I.

    2015-03-17

    There is considerable potential for X-ray free electron lasers (XFELs) to enable determination of macromolecular crystal structures that are difficult to solve using current synchrotron sources. Prior XFEL studies often involved the collection of thousands to millions of diffraction images, in part due to limitations of data processing methods. We implemented a data processing system based on classical post-refinement techniques, adapted to specific properties of XFEL diffraction data. When applied to XFEL data from three different proteins collected using various sample delivery systems and XFEL beam parameters, our method improved the quality of the diffraction data as well as the resulting refined atomic models and electron density maps. Moreover, the number of observations for a reflection necessary to assemble an accurate data set could be reduced to a few observations. These developments will help expand the applicability of XFEL crystallography to challenging biological systems, including cases where sample is limited.

  19. Enabling X-ray free electron laser crystallography for challenging biological systems from a limited number of crystals

    SciTech Connect

    Uervirojnangkoorn, Monarin; Zeldin, Oliver B.; Lyubimov, Artem Y.; Hattne, Johan; Brewster, Aaron S.; Sauter, Nicholas K.; Brunger, Axel T.; Weis, William I.

    2015-03-17

    There is considerable potential for X-ray free electron lasers (XFELs) to enable determination of macromolecular crystal structures that are difficult to solve using current synchrotron sources. Prior XFEL studies often involved the collection of thousands to millions of diffraction images, in part due to limitations of data processing methods. We implemented a data processing system based on classical post-refinement techniques, adapted to specific properties of XFEL diffraction data. When applied to XFEL data from three different proteins collected using various sample delivery systems and XFEL beam parameters, our method improved the quality of the diffraction data as well as the resulting refined atomic models and electron density maps. Moreover, the number of observations for a reflection necessary to assemble an accurate data set could be reduced to a few observations. In conclusion, these developments will help expand the applicability of XFEL crystallography to challenging biological systems, including cases where sample is limited.

  20. Enabling X-ray free electron laser crystallography for challenging biological systems from a limited number of crystals

    DOE PAGES [OSTI]

    Uervirojnangkoorn, Monarin; Zeldin, Oliver B.; Lyubimov, Artem Y.; Hattne, Johan; Brewster, Aaron S.; Sauter, Nicholas K.; Brunger, Axel T.; Weis, William I.

    2015-03-17

    There is considerable potential for X-ray free electron lasers (XFELs) to enable determination of macromolecular crystal structures that are difficult to solve using current synchrotron sources. Prior XFEL studies often involved the collection of thousands to millions of diffraction images, in part due to limitations of data processing methods. We implemented a data processing system based on classical post-refinement techniques, adapted to specific properties of XFEL diffraction data. When applied to XFEL data from three different proteins collected using various sample delivery systems and XFEL beam parameters, our method improved the quality of the diffraction data as well as themore » resulting refined atomic models and electron density maps. Moreover, the number of observations for a reflection necessary to assemble an accurate data set could be reduced to a few observations. These developments will help expand the applicability of XFEL crystallography to challenging biological systems, including cases where sample is limited.« less

  1. Enabling X-ray free electron laser crystallography for challenging biological systems from a limited number of crystals

    DOE PAGES [OSTI]

    Uervirojnangkoorn, Monarin; Zeldin, Oliver B.; Lyubimov, Artem Y.; Hattne, Johan; Brewster, Aaron S.; Sauter, Nicholas K.; Brunger, Axel T.; Weis, William I.

    2015-03-17

    There is considerable potential for X-ray free electron lasers (XFELs) to enable determination of macromolecular crystal structures that are difficult to solve using current synchrotron sources. Prior XFEL studies often involved the collection of thousands to millions of diffraction images, in part due to limitations of data processing methods. We implemented a data processing system based on classical post-refinement techniques, adapted to specific properties of XFEL diffraction data. When applied to XFEL data from three different proteins collected using various sample delivery systems and XFEL beam parameters, our method improved the quality of the diffraction data as well as themore » resulting refined atomic models and electron density maps. Moreover, the number of observations for a reflection necessary to assemble an accurate data set could be reduced to a few observations. In conclusion, these developments will help expand the applicability of XFEL crystallography to challenging biological systems, including cases where sample is limited.« less

  2. E-Link - Disclaimer

    Office of Scientific and Technical Information (OSTI)

    Javascript Not Enabled OSTI Security Website Policies and Important Links

  3. Development and Applications Of Photosensitive Device Systems To Studies Of Biological And Organic Materials

    SciTech Connect

    Gruner, Sol

    2012-01-20

    The primary focus of the grant is the development of new x-ray detectors for biological and materials work at synchrotron sources, especially Pixel Array Detectors (PADs), and the training of students via research applications to problems in biophysics and materials science using novel x-ray methods. This Final Progress Report provides a high-level overview of the most important accomplishments. These major areas of accomplishment include: (1) Development and application of x-ray Pixel Array Detectors; (2) Development and application of methods of high pressure x-ray crystallography as applied to proteins; (3) Studies on the synthesis and structure of novel mesophase materials derived from block co-polymers.

  4. Proactive investigation of hydrocarbons released into a linked groundwater-surfacewater hydrologic system: Chevron Estero Marine Terminal

    SciTech Connect

    Tormey, D. ); Waldron, J. ); Culbertson, D. )

    1996-01-01

    When regulatory concern is high, it is critical to address potential ecological impacts early, and hence [open quotes]close the door[close quotes] on further unnecessary studies, as illustrated by the Chevron Estero Marine Terminal case study. Cutter stock (diesel-like hydrocarbons) leaked from a facility sump, reached the water table, and migrated laterally an unknown distance. Media reports led to heightened public and regulatory concern, and the information gap led to worst-case assumptions about the extent and impact of the release to the biota of a nearby creek (Toro Creek). Chevron undertook a rapid assessment with two goals: define the extent of cutter stock in soil and groundwater, and close the door on expensive biological studies of Toro Creek. The assessment consisted of installing a large number of small-diameter soil borings and temporary well points, monitor wells, and analyzing soil, groundwater, and hydraulic gradient. The information gap was very rapidly filled with the following comprehensive picture: (1) the cutter stock had mixed with heavy crude oil, was highly adsorptive to soil and practically insoluble in water; (2) the cutter stock had not reached Toro Creek; (3) Toro Creek is always a losing stream, hydraulically connected to groundwater beneath the Chevron facility; (4) the groundwater basin is isolated by bedrock boundaries. Early attention to Toro Creek and the Pacific Ocean, and open communication with concerned agencies effectively limited the investigation to soil and water.

  5. Proactive investigation of hydrocarbons released into a linked groundwater-surfacewater hydrologic system: Chevron Estero Marine Terminal

    SciTech Connect

    Tormey, D.; Waldron, J.; Culbertson, D.

    1996-12-31

    When regulatory concern is high, it is critical to address potential ecological impacts early, and hence {open_quotes}close the door{close_quotes} on further unnecessary studies, as illustrated by the Chevron Estero Marine Terminal case study. Cutter stock (diesel-like hydrocarbons) leaked from a facility sump, reached the water table, and migrated laterally an unknown distance. Media reports led to heightened public and regulatory concern, and the information gap led to worst-case assumptions about the extent and impact of the release to the biota of a nearby creek (Toro Creek). Chevron undertook a rapid assessment with two goals: define the extent of cutter stock in soil and groundwater, and close the door on expensive biological studies of Toro Creek. The assessment consisted of installing a large number of small-diameter soil borings and temporary well points, monitor wells, and analyzing soil, groundwater, and hydraulic gradient. The information gap was very rapidly filled with the following comprehensive picture: (1) the cutter stock had mixed with heavy crude oil, was highly adsorptive to soil and practically insoluble in water; (2) the cutter stock had not reached Toro Creek; (3) Toro Creek is always a losing stream, hydraulically connected to groundwater beneath the Chevron facility; (4) the groundwater basin is isolated by bedrock boundaries. Early attention to Toro Creek and the Pacific Ocean, and open communication with concerned agencies effectively limited the investigation to soil and water.

  6. Integrated Omics in Systems Biology: The New Frontier for Environmental Biotechnology

    SciTech Connect

    Hazen, Terry C.

    2008-08-12

    Environmental biotechnology encompasses a wide range of characterization, monitoring and control for bioenergy and bioremediation technologies that are based on biological processes. Recent breakthroughs in our understanding of biogeochemical processes and genomics are leading to exciting new and cost effective ways to monitor and manipulate the environment and potentially produce bioenergy fuels as we also cleanup the environment. Indeed, our ability to sequence an entire microbial genome in just a few hours is leading to similar breakthroughs in characterizing proteomes, metabolomes, phenotypes, and fluxes for organisms, populations, and communities. Understanding and modeling functional microbial community structure and stress responses in subsurface environments has tremendous implications for our fundamental understanding of biogeochemistry and the potential for making biofuel breakthroughs. Monitoring techniques that inventory and monitor terminal electron acceptors and electron donors, enzyme probes that measure functional activity in the environment, functional genomic microarrays, phylogenetic microarrays, metabolomics, proteomics, and quantitative PCR are also being rapidly adapted for studies in environmental biotechnology. Integration of all of these new high throughput techniques using the latest advances in bioinformatics and modeling will enable break-through science in environmental biotechnology. A review of these techniques with examples from field studies and lab simulations will be discussed.

  7. Active dc filter for HVDC system--A test installation in the Konti-Skan DC link at Lindome converter station

    SciTech Connect

    Zhang, Wenyan; Asplund, G. . HVDC Division); Aberg, A. . Dept. of Man-Machine Communication); Jonsson, U. ); Loeoef, O. . Region Vaestsverige)

    1993-07-01

    The purpose of introducing active dc filters is to meet the more and more stringent requirement from power utilities on limiting telephone interference caused by harmonic currents from HVdc transmission lines, without unnecessarily increasing the cost of HVdc stations. An active dc filter installed in the Konti-Skan HVdc link is described. The active dc filter is connected at the bottom of an existing passive dc filter at the Lindome station. The active dc filter includes optic harmonic current measuring unit, control system, protection and supervision system, PWM power amplifier, high-frequency transformer, surge arrester, and coupling apparatuses. The active dc filter has small physical size and occupies small ground area. The performance of the active dc filter for eliminating the disturbing harmonics is excellent. To achieve comparable results by passive filters would require something like ten times more high voltage equipment.

  8. Systems Biology Model of Interactions Between Tissue Growth Factors and DNA Damage Pathways: Low Dose Response and Cross-Talk in TGFbeta and ATM Signaling

    SciTech Connect

    O'Neill, Peter; Anderson, Jennifer

    2014-10-02

    The etiology of radiation carcinogenesis has been described in terms of aberrant changes that span several levels of biological organization. Growth factors regulate many important cellular and tissue functions including apoptosis, differentiation and proliferation. A variety of genetic and epigenetic changes of growth factors have been shown to contribute to cancer initiation and progression. It is known that cellular and tissue damage to ionizing radiation is in part initiated by the production of reactive oxygen species, which can activate cytokine signaling, and the DNA damage response pathways, most notably the ATM signaling pathway. Recently the transforming growth factor β (TGFβ) pathway has been shown to regulate or directly interact with the ATM pathway in the response to radiation. The relevance of this interaction with the ATM pathway is not known although p53 becomes phosphorylated and DNA damage responses are involved. However, growth factor interactions with DNA damage responses have not been elucidated particularly at low doses and further characterization of their relationship to cancer processes is warranted. Our goal will be to use a systems biology approach to mathematically and experimentally describe the low dose responses and cross-talk between the ATM and TGFβ pathways initiated by low and high LET radiation. We will characterize ATM and TGFβ signaling in epithelial and fibroblast cells using 2D models and ultimately extending to 3D organotypic cell culture models to begin to elucidate possible differences that may occur for different cell types and/or inter-cellular communication. We will investigate the roles of the Smad and Activating transcription factor 2 (ATF2) proteins as the potential major contributors to cross- talk between the TGFβ and ATM pathways, and links to cell cycle control and/or the DNA damage response, and potential differences in their responses at low and high doses. We have developed various experimental

  9. Electro-mechanical energy conversion system having a permanent magnet machine with stator, resonant transfer link and energy converter controls

    DOEpatents

    Skeist, S. Merrill; Baker, Richard H.

    2006-01-10

    An electro-mechanical energy conversion system coupled between an energy source and an energy load comprising an energy converter device including a permanent magnet induction machine coupled between the energy source and the energy load to convert the energy from the energy source and to transfer the converted energy to the energy load and an energy transfer multiplexer to control the flow of power or energy through the permanent magnetic induction machine.

  10. A Study to Determine the Biological Feasibility of a New Fish-Tagging System : Annual Report 1998-1999.

    SciTech Connect

    Downing, Sandra L.; Prentice, Earl F.; Peterson, Bradley W.; Nunnallee, Edmund P.; Jonasson, Bruce F.

    2000-09-01

    This report covers our work during 1998 and 1999 (FY99) on a project to expand and improve technology for passive-integrated-transponder tags (PIT tags) throughout the Columbia River Basin. The National Marine Fisheries Service (NMFS) in cooperation with the Bonneville Power Administration (BPA) conducted the work. Timely and accurate information derived from PIT-tag technology is increasingly critical to resource stakeholders in assessing the effectiveness of efforts to enhance survival of juvenile and adult salmonids. Continued development of PIT-tag technology will enable researchers and fisheries managers to address issues expressed in the NMFS biological opinions for operation of the Federal Columbia River Power System (FCRPS) and the proposed Snake River Recovery Plan. The FY99 work was divided into individual projects that are covered separately in this report.

  11. Preparation of a Magnetically Switchable Bioelectrocatalytic System Employing Cross-Linked Enzyme Aggregates in Magnetic Mesocellular Carbon Foam

    SciTech Connect

    Lee, Jinwoo; Lee, Dohun; Oh, Eunkeu; Kim, Jaeyun; Kim, Young-Pil; Jin, Sunmi; Kim, Hak Sung; Hwang, Yosun; Kwak, Ja Hun; Park, Je-Geun; Shin, Chae-Ho; Kim, Jungbae; Hyeon, Taeghwan

    2005-11-18

    Nanostructured magnetic materials (NMMs)[1] have attracted much attention recently because of their broad biotechnological applications including support matrices for enzyme immobilization,[2] immunoassays,[3] drug delivery,[4] and biosensors.[ 5] Specifically, the easy separation and controlled placement of NMMs by means of an external magnetic field enables their application in the development of immobilized enzyme processes[2] and the construction of magnetically controllable bio-electrocatalytic systems.[5, 6] Herein, we demonstrate the use of immobilized enzymes in NMMs for magnetically switchable bio-electrocatalysis.

  12. An adaptive multi-level simulation algorithm for stochastic biological systems

    SciTech Connect

    Lester, C. Giles, M. B.; Baker, R. E.; Yates, C. A.

    2015-01-14

    Discrete-state, continuous-time Markov models are widely used in the modeling of biochemical reaction networks. Their complexity often precludes analytic solution, and we rely on stochastic simulation algorithms (SSA) to estimate system statistics. The Gillespie algorithm is exact, but computationally costly as it simulates every single reaction. As such, approximate stochastic simulation algorithms such as the tau-leap algorithm are often used. Potentially computationally more efficient, the system statistics generated suffer from significant bias unless tau is relatively small, in which case the computational time can be comparable to that of the Gillespie algorithm. The multi-level method [Anderson and Higham, Multi-level Monte Carlo for continuous time Markov chains, with applications in biochemical kinetics, SIAM Multiscale Model. Simul. 10(1), 146179 (2012)] tackles this problem. A base estimator is computed using many (cheap) sample paths at low accuracy. The bias inherent in this estimator is then reduced using a number of corrections. Each correction term is estimated using a collection of paired sample paths where one path of each pair is generated at a higher accuracy compared to the other (and so more expensive). By sharing random variables between these paired paths, the variance of each correction estimator can be reduced. This renders the multi-level method very efficient as only a relatively small number of paired paths are required to calculate each correction term. In the original multi-level method, each sample path is simulated using the tau-leap algorithm with a fixed value of ?. This approach can result in poor performance when the reaction activity of a system changes substantially over the timescale of interest. By introducing a novel adaptive time-stepping approach where ? is chosen according to the stochastic behaviour of each sample path, we extend the applicability of the multi-level method to such cases. We demonstrate the efficiency

  13. Biology and management of insect pests in North American intensively managed hardwood forest systems.

    SciTech Connect

    Coyle, David R.; Nebeker, T., E.; Hart, E., R.; Mattson, W., J.

    2005-01-01

    Annu. Rev. Entomol. 50:1-29. Abstract Increasing demand for wood and wood products is putting stress on traditional forest production areas, leading to long-term economic and environmental concerns. Intensively managed hardwood forest systems (IMHFS), grown using conventional agricultural as well as forestry methods, can help alleviate potential problems in natural forest production areas. Although IMHFS can produce more biomass per hectare per year than natural forests, the ecologically simplified, monocultural systems may greatly increase the crops susceptibility to pests. Species in the genera Populus and Salix comprise the greatest acreage in IMHFS in North America, but other species, including Liquidambar styracifua and Platanus occidentalis, are also important. We discuss life histories, realized and potential damage, and management options for the most economically infuential pests that affect these hardwood species. The substantial inherent challenges associated with pest management in the monocultural environments created by IMHFS are reviewed. Finally, we discuss ways to design IMHFS that may reduce their susceptibility to pests, increase their growth and productivity potential, and create a more sustainable environment.

  14. A Study to Determine the Biological Feasability of a New Fish Tagging System : Annual Report, 1986-1987.

    SciTech Connect

    Prentice, Earl F.; Flagg, T.A.

    1987-12-01

    In 1983, a multi-year project to evaluate the technical and biological feasibility of adapting a new identification system to salmonids was established. The system is based upon a miniaturized passive integrated transponder (PIT) tag. This report discusses the work completed and is divided into laboratory studies, field studies, and systems development. All studies were conducted using a glass-encapsulated tag implanted into the body cavity of test fish via a 12-gauge hypodermic needle. Laboratory studies with juvenile chinook salmon, Oncorhynchus tshawytscha, showed that retention of glass-encapsulated PIT tags was 99-100% in fish weighing 3 g (mean weight) or larger. No adverse tissue response to the tag was noted. The survival of fish 5 g (mean weight) or larger was usually greater than 99%. However, fish ranging in weight from 2 to 4 g, or fish undergoing a physiological change such as smoltification may have a low mortality (usually less than 5.0%) after tagging. The mortality rate in the smaller fish was dependent upon tagging skill whereas mortality in smolting fish seemed dependent upon the level of stress. Growth comparisons between tagged and control fish indicated PIT-tagged fish had a slightly depressed growth rate at some measurement periods. The operational life of glass-encapsulated PIT tags implanted in fish was good, with 100% of the tags operating after 401 days. No tags were rejected from the fish during the observation period.

  15. Energy Efficiency Links

    Energy Information Administration (EIA) (indexed site)

    Energy Efficiency Organizations Energy Efficiency Organizations Release Date: October 1999 Last Updated: Septembert 2009 EIA Links Disclaimer: These pages contain hypertext links...

  16. Emerging semantics to link phenotype and environment

    DOE PAGES [OSTI]

    Thessen, Anne E.; Bunker, Daniel E.; Buttigieg, Pier Luigi; Cooper, Laurel D.; Dahdul, Wasila M.; Domisch, Sami; Franz, Nico M.; Jaiswal, Pankaj; Lawrence-Dill, Carolyn J.; Midford, Peter E.; et al

    2015-12-14

    Understanding the interplay between environmental conditions and phenotypes is a fundamental goal of biology. Unfortunately, data that include observations on phenotype and environment are highly heterogeneous and thus difficult to find and integrate. One approach that is likely to improve the status quo involves the use of ontologies to standardize and link data about phenotypes and environments. Specifying and linking data through ontologies will allow researchers to increase the scope and flexibility of large-scale analyses aided by modern computing methods. Investments in this area would advance diverse fields such as ecology, phylogenetics, and conservation biology. While several biological ontologies aremore » well-developed, using them to link phenotypes and environments is rare because of gaps in ontological coverage and limits to interoperability among ontologies and disciplines. Lastly, in this manuscript, we present (1) use cases from diverse disciplines to illustrate questions that could be answered more efficiently using a robust linkage between phenotypes and environments, (2) two proof-of-concept analyses that show the value of linking phenotypes to environments in fishes and amphibians, and (3) two proposed example data models for linking phenotypes and environments using the extensible observation ontology (OBOE) and the Biological Collections Ontology (BCO); these provide a starting point for the development of a data model linking phenotypes and environments.« less

  17. Emerging semantics to link phenotype and environment

    SciTech Connect

    Thessen, Anne E.; Bunker, Daniel E.; Buttigieg, Pier Luigi; Cooper, Laurel D.; Dahdul, Wasila M.; Domisch, Sami; Franz, Nico M.; Jaiswal, Pankaj; Lawrence-Dill, Carolyn J.; Midford, Peter E.; Mungall, Christopher J.; Ramirez, Martin J.; Specht, Chelsea D.; Vogt, Lars; Vos, Rutger Aldo; Walls, Ramona L.; White, Jeffrey W.; Zhang, Guanyang; Deans, Andrew R.; Huala, Eva; Lewis, Suzanna E.; Mabee, Paula M.

    2015-12-14

    Understanding the interplay between environmental conditions and phenotypes is a fundamental goal of biology. Unfortunately, data that include observations on phenotype and environment are highly heterogeneous and thus difficult to find and integrate. One approach that is likely to improve the status quo involves the use of ontologies to standardize and link data about phenotypes and environments. Specifying and linking data through ontologies will allow researchers to increase the scope and flexibility of large-scale analyses aided by modern computing methods. Investments in this area would advance diverse fields such as ecology, phylogenetics, and conservation biology. While several biological ontologies are well-developed, using them to link phenotypes and environments is rare because of gaps in ontological coverage and limits to interoperability among ontologies and disciplines. Lastly, in this manuscript, we present (1) use cases from diverse disciplines to illustrate questions that could be answered more efficiently using a robust linkage between phenotypes and environments, (2) two proof-of-concept analyses that show the value of linking phenotypes to environments in fishes and amphibians, and (3) two proposed example data models for linking phenotypes and environments using the extensible observation ontology (OBOE) and the Biological Collections Ontology (BCO); these provide a starting point for the development of a data model linking phenotypes and environments.

  18. MicroLink Devices Inc | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    search Name: MicroLink Devices, Inc. Place: Niles, Illinois Product: MicroLink Devices is a semiconductor manufacturer and system integrator that provides the latest...

  19. Website Policies / Important Links | Geothermal

    Office of Scientific and Technical Information (OSTI)

    Website Policies Important Links Website Policies Important Links Javascript Not Enabled OSTI Security Website Policies and Important Links

  20. Website Policies / Important Links | sciencecinema

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Website Policies / Important Links Website Policies / Important Links Javascript Not Enabled OSTI Security Website Policies and Important Links

  1. Website Policies / Important Links | sciencecinema

    Office of Scientific and Technical Information (OSTI)

    Website Policies / Important Links Website Policies / Important Links Javascript Not Enabled OSTI Security Website Policies and Important Links

  2. Website Policies / Important Links | Geothermal

    Office of Scientific and Technical Information (OSTI)

    Website Policies / Important Links Website Policies / Important Links Javascript Not Enabled OSTI Security Website Policies and Important Links

  3. Feedstock Related Links | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Related Links Feedstock Related Links There are a variety of other resources available for information on biomass feedstocks. We have organized some of those resources into the following categories: Other DOE Offices and Federal Agencies Department of Energy (DOE) Office of Science Biological and Environmental Research (BER) Biofuels Mission Focus DOE Office of Science BER Bioenergy Research Centers U.S. Department of Agriculture (USDA) 2007 Farm Bill Energy Provision USDA Agriculture Research

  4. Systems Biology Approaches to Dissecting Plant Cell Wall Biosynthesis Genes in Poplus (JGI Seventh Annual User Meeting 2012: Genomics of Energy and Environment)

    ScienceCinema

    Glass, N Louise [UC Berkeley

    2016-07-12

    N. Louise Glass from the University of California, Berkeley, presents a talk titled "Systems Biology Approaches to Dissecting Plant Cell Wall Biosynthesis Genes in Poplus" at the JGI 7th Annual Users Meeting: Genomics of Energy & Environment Meeting on March 22, 2012 in Walnut Creek, California.

  5. Systems Biology Approaches to Dissecting Plant Cell Wall Biosynthesis Genes in Poplus (JGI Seventh Annual User Meeting 2012: Genomics of Energy and Environment)

    SciTech Connect

    Glass, N Louise [UC Berkeley] [UC Berkeley

    2012-03-22

    N. Louise Glass from the University of California, Berkeley, presents a talk titled "Systems Biology Approaches to Dissecting Plant Cell Wall Biosynthesis Genes in Poplus" at the JGI 7th Annual Users Meeting: Genomics of Energy & Environment Meeting on March 22, 2012 in Walnut Creek, California.

  6. Compiling & Linking | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    System Overview Data Storage & File Systems Compiling & Linking Overview of How to Compile and Link Example Program and Makefile for BG/Q How to Manage Threading bgclang Compiler Compiling and Linking FAQ Queueing & Running Jobs Data Transfer Debugging & Profiling Performance Tools & APIs Software & Libraries IBM References Cooley Policies Documentation Feedback Please provide feedback to help guide us as we continue to build documentation for our new computing resource.

  7. Helpful Links - Hanford Site

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Helpful Links Helpful Links Helpful Links Hanford Staff Directory Hanford Site Wide Programs Energy Employees Occupational Illness Compensation Hanford Workers Compensation Projects & Facilities HERO PHOENIX Hanford Meteorological Station Definitions Abbreviations and Acronyms Visitor Control and Site Access Visitor Hanford Computer Access Request Helpful Links Email Email Page | Print Print Page | Text Increase Font Size Decrease Font Size Contact Us Do you have a question? Contact Hanford

  8. Autofermentative Biological Hydrogen Production by Cyanobacteria...

    Energy.gov [DOE] (indexed site)

    More Documents & Publications 2013 Biological Hydrogen Production Workshop Summary Report Renewable Hydrogen Production from Biological Systems Anthropogenic CO2 as a Feedstock for ...

  9. FRAMES-2.0 Software System: Linking to the Groundwater Modeling System (GMS) RT3D and MT3DMS Models

    SciTech Connect

    Whelan, Gene; Castleton, Karl J.; Pelton, Mitch A.

    2007-08-08

    Linkages to the Groundwater Modeling System have been developed at Pacific Northwest National Laboratory to enable the Nuclear Regulatory Commission (NRC) to more realistically assess the risk to the public of radioactive contaminants at NRC-licensed sites. Common software tools presently in use are limited in that they cannot assess contaminant migration through complex natural environments. The purpose of this initiative is to provide NRC with a licensing safety-analysis tool with sufficient power, flexibility, and utility that it can serve as the primary software platform for analyzing the hazards associated with licensing actions at those complex sites at which the traditional tools are inappropriate. As a tool designed to realistically approximate prospective doses to the public, this initiative addresses NRCs safety-performance goal by confirming that licensing actions do not result in undue risk to the public.

  10. Biological Safety

    Office of Energy Efficiency and Renewable Energy (EERE)

    The DOE's Biological Safety Program provides a forum for the exchange of best practices, lessons learned, and guidance in the area of biological safety. This content is supported by the Biosurety Executive Team. The Biosurety Executive Team is a DOE-chartered group. The DOE Office of Worker Safety and Health Policy provides administrative support for this group. The group identifies biological safety-related issues of concern to the DOE and pursues solutions to issues identified.

  11. Biological Applications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Biological Applications Biological Applications Bioscience technologies for biosecurity, infectious disease, and other threats. Bioscience Capabilities-for Collaboration View our capability sheets: get details of what we do. Atomic Magnetometer Micro Imaging MOL PCR Raman LIBS Waveguide Biosensor How we deploy innovation bioscience-foundational-science Cell biology hasn't been the same since Los Alamos pioneered flow cytometry in mid-1960s when a Lab scientist invented a cell separator that

  12. Development of an Implementation Plan Related to Biological Opinion on Operation of the Federal Columbia River Power System ; Step 1: Review and Critique of Implementation Plans.

    SciTech Connect

    Neitzel, Duane A.; Bunn, Amoret

    2000-12-01

    The Draft Biological Opinion on Operation of the Federal Columbia River Power System calls for the development of 1- and 5-year implementation plans. These plans will provide the roadmap for planning and subsequent implementation of actions intended to meet specific performance standards (i.e., biological objectives) in a timely manner. To develop implementation plans the key tasks and sequences of steps must be determined. Those responsible for specific tasks must be identified and they must understand what they need to do. There must be assurances that the resources (human, physical, and fiscal) to complete the tasks are available. Motivation and incentive systems should be set up. Systems to coordinate efforts and guide activity must be devised and installed. An information management system must be designed to manage and analyze data and ensure that appropriate data are collected. This will aid managers in assessing whether individual activities or actions are tracking with stated goals and objectives. Training programs to improve managerial and worker capability in making and implementing plans should be designed. Managerial leadership to guide the efforts of all individuals in achieving the goals of the anadromous and resident fish recovery must be developed. It is the entire process of managing fish recovery in relationship to the Biological Opinion that will guide, coordinate, motivate, and control work and determine the effectiveness and efficiency of plan implementation.

  13. ARM - Quick Links

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Links Related Links ISDAC Home AAF Home AVP Aircraft Instrumentation, October 14-16, 2008 ARM Data Discovery Browse Data Post-Campaign Data Sets Flight Summary Table (PDF, 440K) ISDAC Wiki Mission Summary Journal Deployment Resources NSA Site ARM Data Plots Quick Links Experiment Planning ISDAC Proposal Abstract Full Proposal (pdf, 1,735K) Science Questions Science Overview Document for ISDAC (pdf, 525K) ISDAC Flight Planning Document (PDF, 216K) Collaborations Logistics Measurements &

  14. Related Links - Hanford Site

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Related Links Hanford Advisory Board Convening Report SSAB Guidance Memorandum of Understanding Membership Nomination and Appointment Process Operating Ground Rules Calendars Advice and Responses Full Board Meeting Information Committee Meeting Information Outgoing Board Correspondence Key Board Products and Special Reports HAB Annual Report HAB and Committee Lists Points of Contact Related Links Related Links Email Email Page | Print Print Page | Text Increase Font Size Decrease Font Size

  15. AlumniLink

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    AlumniLink Alumni Link: Opportunities, News and Resources for Former Employees Latest Issue:September 2015 all issues All Issues » submit AlumniLink Bi-monthly publication connecting our alumni with news, information and former colleagues from the Lab. Alumni September 2015 September 2015 Neutrons find "missing" magnetism of plutonium Young, Jupiter-like planet discovered Four Los Alamos projects selected as R&D 100 Award finalists SHARE Alumni July 2015 July 2015 Mars Rover's

  16. Nuclear Data Links

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Links to Useful Online Nuclear Physics Journals Important Online Resources Science Direct ... Elsevier Physics Online: Nuclear Physics A, B, Physics Repots, Physics Letters B and more. ...

  17. Links (pbl/contracts)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Implementation Links to related sites Regional Dialogue Transmission Regional Dialogue issues Team ASC Methodology 2012 BPA Rate Case Page content last modified on: April 06, 2010...

  18. Related Links - Hanford Site

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Links Tri-Party Agreement The Agreement Announcements List of Approved Changes TPA Project Manager's Lists Modifications for Public Comment Data Management MP-14 WIDS...

  19. Biological and Environmental Research

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Biological and Environmental Research Biological and Environmental Research Understanding how genomic information is translated to functional capabilities, and the roles of Earth's biogeochemical systems so we can predict climate decades or centuries into the future. Get Expertise James Bossert (505) 667-3644 Email Cathy Wilson (505) 667-0202 Email Srinivas Iyer (505) 667-2690 Email Conducting research into sustainable biofuel production, improved carbon storage, and climate driven by a

  20. National Laboratory] Basic Biological Sciences(59) Biological...

    Office of Scientific and Technical Information (OSTI)

    Achievements of structural genomics Terwilliger, Thomas C. Los Alamos National Laboratory Basic Biological Sciences(59) Biological Science Biological Science Abstract Not...

  1. ARM - Related Links

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Related Links Related Links TWP-ICE Home Tropical Western Pacific Home ARM Data Discovery Browse Data Post-Experiment Data Sets Weather Summary (pdf, 6M) New York Workshop Presentations Experiment Planning TWP-ICE Proposal Abstract Detailed Experiment Description Science Plan (pdf, 1M) Operations Plan (pdf, 321K) Maps Contact Info Related Links Daily Report Report Archives Press Media Coverage TWP-ICE Fact Sheet (pdf, 211K) Press Releases TWP-ICE Images ARM flickr site <=""

  2. Biological and Chemical Security

    SciTech Connect

    Fitch, P J

    2002-12-19

    The LLNL Chemical & Biological National Security Program (CBNP) provides science, technology and integrated systems for chemical and biological security. Our approach is to develop and field advanced strategies that dramatically improve the nation's capabilities to prevent, prepare for, detect, and respond to terrorist use of chemical or biological weapons. Recent events show the importance of civilian defense against terrorism. The 1995 nerve gas attack in Tokyo's subway served to catalyze and focus the early LLNL program on civilian counter terrorism. In the same year, LLNL began CBNP using Laboratory-Directed R&D investments and a focus on biodetection. The Nunn-Lugar-Domenici Defense Against Weapons of Mass Destruction Act, passed in 1996, initiated a number of U.S. nonproliferation and counter-terrorism programs including the DOE (now NNSA) Chemical and Biological Nonproliferation Program (also known as CBNP). In 2002, the Department of Homeland Security was formed. The NNSA CBNP and many of the LLNL CBNP activities are being transferred as the new Department becomes operational. LLNL has a long history in national security including nonproliferation of weapons of mass destruction. In biology, LLNL had a key role in starting and implementing the Human Genome Project and, more recently, the Microbial Genome Program. LLNL has over 1,000 scientists and engineers with relevant expertise in biology, chemistry, decontamination, instrumentation, microtechnologies, atmospheric modeling, and field experimentation. Over 150 LLNL scientists and engineers work full time on chemical and biological national security projects.

  3. Biological preconcentrator

    DOEpatents

    Manginell, Ronald P.; Bunker, Bruce C.; Huber, Dale L.

    2008-09-09

    A biological preconcentrator comprises a stimulus-responsive active film on a stimulus-producing microfabricated platform. The active film can comprise a thermally switchable polymer film that can be used to selectively absorb and desorb proteins from a protein mixture. The biological microfabricated platform can comprise a thin membrane suspended on a substrate with an integral resistive heater and/or thermoelectric cooler for thermal switching of the active polymer film disposed on the membrane. The active polymer film can comprise hydrogel-like polymers, such as poly(ethylene oxide) or poly(n-isopropylacrylamide), that are tethered to the membrane. The biological preconcentrator can be fabricated with semiconductor materials and technologies.

  4. Carbon Cycling and Biosequestration Integrating Biology and Climate Through Systems Science Report from the March 2008 Workshop

    SciTech Connect

    Graber, J.; Amthor, J.; Dahlman, R.; Drell, D.; Weatherwax, S.

    2008-12-01

    One of the most daunting challenges facing science in the 21st Century is to predict how Earth's ecosystems will respond to global climate change. The global carbon cycle plays a central role in regulating atmospheric carbon dioxide (CO{sub 2}) levels and thus Earth's climate, but our basic understanding of the myriad of tightly interlinked biological processes that drive the global carbon cycle remains limited at best. Whether terrestrial and ocean ecosystems will capture, store, or release carbon is highly dependent on how changing climate conditions affect processes performed by the organisms that form Earth's biosphere. Advancing our knowledge of biological components of the global carbon cycle is thus crucial to predicting potential climate change impacts, assessing the viability of climate change adaptation and mitigation strategies, and informing relevant policy decisions. Global carbon cycling is dominated by the paired biological processes of photosynthesis and respiration. Photosynthetic plants and microbes of Earth's land-masses and oceans use solar energy to transform atmospheric CO{sub 2} into organic carbon. The majority of this organic carbon is rapidly consumed by plants or microbial decomposers for respiration and returned to the atmosphere as CO{sub 2}. Coupling between the two processes results in a near equilibrium between photosynthesis and respiration at the global scale, but some fraction of organic carbon also remains in stabilized forms such as biomass, soil, and deep ocean sediments. This process, known as carbon biosequestration, temporarily removes carbon from active cycling and has thus far absorbed a substantial fraction of anthropogenic carbon emissions.

  5. Biological Mass Spectrometry and Shotgun Proteomics of Microbial Systems: Methods for studying microbial physiology from isolates to environmental communities

    SciTech Connect

    Dill, Brian; Young, Jacque C; Carey, Patricia A; Verberkmoes, Nathan C

    2010-01-01

    Microbial ecology is currently experiencing a renaissance spurred by the rapid development of molecular techniques and omics technologies in particular. As never before, these tools have allowed researchers in the field to produce a massive amount of information through in situ measurements and analysis of natural microbial communities, both vital approaches to the goal of unraveling the interactions of microbes with their environment and with one another. While genomics can provide information regarding the genetic potential of microbes, proteomics characterizes the primary end-stage product, proteins, thus conveying functional information concerning microbial activity. Advances in mass spectrometry instrumentation and methodologies, along with bioinformatic approaches, have brought this analytic chemistry technique to relevance in the biological realm due to its powerful applications in proteomics. Mass spectrometry-enabled proteomics, including bottom-up and top-down approaches, is capable of supplying a wealth of biologically-relevant information, from simple protein cataloging of the proteome of a microbial community to identifying post-translational modifications of individual proteins.

  6. EEO Links | National Nuclear Security Administration | (NNSA)

    National Nuclear Security Administration (NNSA)

    Links DOE Office of Civil Rights Department Of Justice Civil Rights Division Department of Veterans Affairs Equal Employment Opportunity Commission Office of Personnel Management U.S. Merit Systems Protection Board U.S. Office of Special Counsel

  7. Toward an Earth System Modeling Approach to Simulate Irrigation Effects |

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    U.S. DOE Office of Science (SC) Toward an Earth System Modeling Approach to Simulate Irrigation Effects Biological and Environmental Research (BER) BER Home About Research Facilities Science Highlights Searchable Archive of BER Highlights External link Benefits of BER Funding Opportunities Biological & Environmental Research Advisory Committee (BERAC) Community Resources Contact Information Biological and Environmental Research U.S. Department of Energy SC-23/Germantown Building 1000

  8. (Biological dosimetry)

    SciTech Connect

    Preston, R.J.

    1990-12-17

    The traveler attended the 1st International Conference on Biological Dosimetry in Madrid, Spain. This conference was organized to provide information to a general audience of biologists, physicists, radiotherapists, industrial hygiene personnel and individuals from related fields on the current ability of cytogenetic analysis to provide estimates of radiation dose in cases of occupational or environmental exposure. There is a growing interest in Spain in biological dosimetry because of the increased use of radiation sources for medical and occupational uses, and with this the anticipated and actual increase in numbers of overexposure. The traveler delivered the introductory lecture on Biological Dosimetry: Mechanistic Concepts'' that was intended to provide a framework by which the more applied lectures could be interpreted in a mechanistic way. A second component of the trip was to provide advice with regard to several recent cases of overexposure that had been or were being assessed by the Radiopathology and Radiotherapy Department of the Hospital General Gregorio Maranon'' in Madrid. The traveler had provided information on several of these, and had analyzed cells from some exposed or purportedly exposed individuals. The members of the biological dosimetry group were referred to individuals at REACTS at Oak Ridge Associated Universities for advice on follow-up treatment.

  9. A New Link Between Human and Bacterial Signaling Machinery

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    A New Link Between Human and Bacterial Signaling Machinery A New Link Between Human and Bacterial Signaling Machinery Print Tuesday, 19 August 2014 10:34 The human immune system...

  10. A Study to Determine the Biological Feasibility of a New Fish Tagging System : Annual Report 1990-1993.

    SciTech Connect

    Prentice, Earl F.; Maynard, D.J.; Downing, S.L. (and others)

    1994-01-01

    In 1983, the National Marine Fisheries Service (NMFS) began a multiyear cooperative research program with the Bonneville Power Administration (BPA) to evaluate a new miniaturized identification system that could be used with salmonids. The system is referred to as the passive-integrated-transponder (PIT) tagging and interrogation system. The program has focused on determining the effects of PIT tags on juvenile and adult salmonids, as well as the development and evaluation of tagging and interrogation methods. Earlier results of the program have been reported in annual reports and journal articles cited in this report. This report covers the work per formed from 1990 through 1993. For convenience, the report is divided into three sections: (1) Interrogation and separation systems at Columbia River Basin dams; (2) Systems development and evaluation; and (3) Information and technology transfer.

  11. Related Links | Department of Energy

    Office of Environmental Management (EM)

    Information Resources Related Links Related Links These resources provide more information about wind energy research within the United States and abroad. Consumer and ...

  12. AlumniLink: May 2015

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Join our highlighted LinkedIn discussion Join our highlighted LinkedIn discussion Descartes Labs is using deep learning technology developed at LANL to help us better...

  13. Biological Treatment of Ammonia-Rich Wastewaters by Natural Microbial Communities in the ATOXIC/ASSET Purification System

    SciTech Connect

    Vishnivetskaya, Tatiana A; Fisher, L. Suzanne; Brodie, Greg A; Phelps, Tommy Joe

    2013-01-01

    Analyses of bacterial and archaeal 16S rRNA genes along with high throughput 454 pyrosequencing technology were used to identify microbial communities present at a novel passive wastewater treatment system designed to remove ammonium, nitrate, and heavy metals from fossil plant effluents. Seasonal changes in microbial community composition were observed, however significant (p=0.001) changes were detected in bacterial and archaeal communities consistent with ammonium removal throughout the treatment systems. Phylogenetic analysis of 16S rRNA gene sequences revealed presence of potential ammonium-oxidizing bacteria (AOB), Nitrosomonas, Nitrosococcus, Planctomycetes, and OD1. Other bacteria, such as Nitrospira, Nitrococcus, Nitrobacter, Thiobacillus, -Proteobacteria, Firmicutes, Acidobacteria, which play roles in nitrification and denitrification, were also detected. The relative abundance of the potential ammonium-oxidizing archaea (AOA) (Thermoprotei within the phylum Crenarchaeota) increased with ammonium availability at the splitter box and zero-valent iron extraction trenches even though AOB removed half of the ammonium in the trickling filters at the beginning of the treatment system. The microbial community removed the ammonium from the wastewater within both pilot-scale treatment systems, thus the treatment system components provided an effective environment for the treatment of ammonium enriched wastewater from coal burning power plants equipped with selective catalytic reducers for nitrogen oxide removal.

  14. Page 11, Links

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    11 of 11 Previous Page Links Information for Employees & In-Processing DOE Order 3792.3 - Drug-Free Federal Workplace Testing http://www.archives.gov/federal-register/codification/executive-order/12564.html Flexible Spending Accounts (FSA) https://www.fsafeds.com/fsafeds/index.asp Pay & Pay Scales http://www.opm.gov/a-z-index/ Benefits Facts on Leave Programs http://www.opm.gov/policy-data-oversight/pay-leave/leave-administration/ Health Benefits

  15. Nuclear Data Links

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Links to Other Useful Sites Online Journals Institutions and Programs Related to Nuclear Physics U.S. Nuclear Data Program: All evaluated nuclear data supported by the U.S. Department of Energy. National Nuclear Data Center: Brookhaven National Laboratory; Evaluated Nuclear Structure Data Files (ENSDF), Nuclear Science References (NSR) and other databases. Isotopes Project: (E.O.L. Berkeley National Laboratory) Table of Isotopes, Isotope Explorer, XUNDL, Nuclear Data Dissemination Homepage, and

  16. CAMD Nanofabrication Links

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Research :: Publications :: Infrastructure :: Links :: Nanofabrication Facility in News Nano 50TM Awards: The Nano 50TM Awards, presented by Nanotech Briefs magazine, recognize the top 50 technologies, products and innovators that have significantly impacted, or are expected to impact, the state of the art in nanotechnology. "The winners of the Nano 50 awards are the best of the best - the innovative people and technologies that will continue to move nanotechnology to key mainstream

  17. Balanced link for dry coal extrusion pumps

    DOEpatents

    Bebejian, Maral

    2013-10-22

    A link which defines a link body that includes a multiple of link plates integral with a link body, the link body disposed at least partially forward of a forward edge of the multiple of link plates.

  18. The Encyclopedia of Systems Biology and OMICS (first presentation) and The ISA Infrastructure for Multi-omics Data (second presentation) (GSC8 Meeting)

    ScienceCinema

    Kolker, Eugene [Seattle Children's Hospital; Sansone, Susanna [EBI

    2016-07-12

    The Genomic Standards Consortium was formed in September 2005. It is an international, open-membership working body which promotes standardization in the description of genomes and the exchange and integration of genomic data. The 2009 meeting was an activity of a five-year funding "Research Coordination Network" from the National Science Foundation and was organized held at the DOE Joint Genome Institute with organizational support provided by the JGI and by the University of California - San Diego. Eugene Kolker from Seattle Children's Hospital briefly discusses "The Encyclopedia of Systems Biology and OMICS," followed by Susanna Sansone from the EBI on "The ISA Infrastructure for multi-omics data" at the Genomic Standards Consortium's 8th meeting at the DOE JGI in Walnut Creek, Calif. on Sept. 11, 2009.

  19. The Encyclopedia of Systems Biology and OMICS (first presentation) and The ISA Infrastructure for Multi-omics Data (second presentation) (GSC8 Meeting)

    SciTech Connect

    Kolker, Eugene; Sansone, Susanna

    2011-09-11

    The Genomic Standards Consortium was formed in September 2005. It is an international, open-membership working body which promotes standardization in the description of genomes and the exchange and integration of genomic data. The 2009 meeting was an activity of a five-year funding "Research Coordination Network" from the National Science Foundation and was organized held at the DOE Joint Genome Institute with organizational support provided by the JGI and by the University of California - San Diego. Eugene Kolker from Seattle Children's Hospital briefly discusses "The Encyclopedia of Systems Biology and OMICS," followed by Susanna Sansone from the EBI on "The ISA Infrastructure for multi-omics data" at the Genomic Standards Consortium's 8th meeting at the DOE JGI in Walnut Creek, Calif. on Sept. 11, 2009.

  20. Genomic and Systems Biology Analyses of Social Behavior or Evolutionary Genomic Analyses of Insect Society: Eat, Drink, and Be Scary (2011 JGI User Meeting)

    ScienceCinema

    Robinson, Gene

    2016-07-12

    The U.S. Department of Energy Joint Genome Institute (JGI) invited scientists interested in the application of genomics to bioenergy and environmental issues, as well as all current and prospective users and collaborators, to attend the annual DOE JGI Genomics of Energy & Environment Meeting held March 22-24, 2011 in Walnut Creek, Calif. The emphasis of this meeting was on the genomics of renewable energy strategies, carbon cycling, environmental gene discovery, and engineering of fuel-producing organisms. The meeting features presentations by leading scientists advancing these topics. Gene Robinson of the University of Illinois on "Genomic and Systems Biology Analyses of Social Behavior" at the 6th Annual Genomics of Energy & Environment Meeting on March 23, 2011

  1. Genomic and Systems Biology Analyses of Social Behavior or Evolutionary Genomic Analyses of Insect Society: Eat, Drink, and Be Scary (2011 JGI User Meeting)

    SciTech Connect

    Robinson, Gene

    2011-03-23

    The U.S. Department of Energy Joint Genome Institute (JGI) invited scientists interested in the application of genomics to bioenergy and environmental issues, as well as all current and prospective users and collaborators, to attend the annual DOE JGI Genomics of Energy & Environment Meeting held March 22-24, 2011 in Walnut Creek, Calif. The emphasis of this meeting was on the genomics of renewable energy strategies, carbon cycling, environmental gene discovery, and engineering of fuel-producing organisms. The meeting features presentations by leading scientists advancing these topics. Gene Robinson of the University of Illinois on "Genomic and Systems Biology Analyses of Social Behavior" at the 6th Annual Genomics of Energy & Environment Meeting on March 23, 2011

  2. Conservation Standards Enforcement: Useful Links | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Useful Links Conservation Standards Enforcement: Useful Links This page provides a variety of links to help manufacturers fulfill their compliance obligations under the energy conservation standards program for consumer products and industrial equipment. Under the applicable law (42 U.S.C. 6291-6317), an importer is a manufacturer; therefore, any material you read in the links below that references a "manufacturer" also applies to an importer. Certification Compliance Management System

  3. Algal Biology Toolbox Workshop Summary Report

    Office of Energy Efficiency and Renewable Energy (EERE)

    The Algal Biology Toolbox Workshop Summary Report summarizes an event hosted by the U.S. Department of Energy’s Bioenergy Technologies Office’s Advanced Algal Systems Program in May 2016. The purpose of the Algal Biology Toolbox Workshop was to collect input from experts in the field of algal biology regarding (1) the current state of algal biological tools, including our understanding of algal biology and biochemistry, available molecular toolboxes, omics databases, and other resources; (2) challenges to developing and applying a full suite of biological tools to improve algae performance and system robustness; and (3) strategies to advance progress toward commercial algal biofuels.

  4. Website Policies / Important Links | DOE Patents

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Website Policies / Important Links Website Policies / Important Links Javascript Not Enabled OSTI Security Website Policies and Important Links

  5. Website Policies / Important Links | Data Explorer

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Website Policies / Important Links Website Policies / Important Links Javascript Not Enabled OSTI Security Website Policies and Important Links

  6. Website Policies / Important Links | DOE PAGES

    Office of Scientific and Technical Information (OSTI)

    Website Policies Important Links Website Policies Important Links Javascript Not Enabled OSTI Security Website Policies and Important Links

  7. Website Policies / Important Links | DOE PAGES

    Office of Scientific and Technical Information (OSTI)

    Website Policies / Important Links Website Policies / Important Links Javascript Not Enabled OSTI Security Website Policies and Important Links

  8. Website Policies / Important Links | Data Explorer

    Office of Scientific and Technical Information (OSTI)

    Website Policies / Important Links Website Policies / Important Links Javascript Not Enabled OSTI Security Website Policies and Important Links

  9. Website Policies / Important Links | DOE Patents

    Office of Scientific and Technical Information (OSTI)

    Website Policies / Important Links Website Policies / Important Links Javascript Not Enabled OSTI Security Website Policies and Important Links

  10. Grid-Interactive Electric Vehicle DC-Link Photovoltaic Charging...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Find More Like This Return to Search Grid-Interactive Electric Vehicle DC-Link Photovoltaic Charging System University of Colorado Contact CU About This Technology Publications: ...

  11. DOE Publishes Roadmap for New Biological Research for Energy...

    Office of Science (SC)

    plan for a new generation of biology research that builds on genome project ... The Genomics: GTL Roadmap: Systems Biology for Energy and Environment outlines a plan to ...

  12. Detter, John C. [Los Alamos National Laboratory] Basic Biological

    Office of Scientific and Technical Information (OSTI)

    State of the Art for Autonomous Detection Systems using Genomic Sequencing Detter, John C. Los Alamos National Laboratory Basic Biological Sciences(59) Biological Science...

  13. Acidbase bifunctional shell cross-linked micelle nanoreactor for one-pot tandem reaction

    DOE PAGES [OSTI]

    Lee, Li -Chen; Lu, Jie; Weck, Marcus; Jones, Christopher W.

    2015-12-29

    Shell cross-linked micelles (SCMs) containing acid sites in the shell and base sites in the core are prepared from amphiphilic poly(2-oxazoline) triblock copolymers. The materials are utilized as two-chamber nanoreactors for a prototypical acid-base bifunctional tandem deacetalization-nitroaldol reaction. Furthermore, the acid and base sites are localized in different regions of the micelle, allowing the two steps in the reaction sequence to largely proceed in separate compartments, akin to the compartmentalization that occurs in biological systems.

  14. Acid–base bifunctional shell cross-linked micelle nanoreactor for one-pot tandem reaction

    SciTech Connect

    Lee, Li -Chen; Lu, Jie; Weck, Marcus; Jones, Christopher W.

    2015-12-29

    Shell cross-linked micelles (SCMs) containing acid sites in the shell and base sites in the core are prepared from amphiphilic poly(2-oxazoline) triblock copolymers. The materials are utilized as two-chamber nanoreactors for a prototypical acid-base bifunctional tandem deacetalization-nitroaldol reaction. Furthermore, the acid and base sites are localized in different regions of the micelle, allowing the two steps in the reaction sequence to largely proceed in separate compartments, akin to the compartmentalization that occurs in biological systems.

  15. Link Alpha L

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Accommodation Program Laser Ablation: Advanced Laser Technologies Lab Laser Management System (Laser Inventory) Laser Safety Web Page Lasers, Optical Accelerator Systems...

  16. Link Alpha F

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Verification Project FAQ on Computing Topics Financial Compliance Financial Management System (FMS 8.8 - FY14 and Prior) Financial Management System (FMS 9.2 - FY15+)...

  17. Subdiffraction instrumentation development and application to the elucidation of biological systems, thin films, and organic photovoltaic devices

    SciTech Connect

    Lesoine, Michael D

    2014-12-01

    Fluorescence and Raman instrumentation was developed to elucidate morphology, information on local environment, and material properties of target systems. Far-field fluorescence and luminescence spectroscopic measurements were performed using a pulsed super-continuum laser source and detector with high temporal resolution. With this arrangement morphologies of structures were coupled with time-correlated data. Polymeric beads and Alexa Fluor 594-phalloidin labeled cellular actin structures of cultured cells were imaged below the diffraction limit using stimulated emission depletion to resolve structures to ≈40nm. Lifetime imaging revealed a 2.0 ± 0.1 ns lifetime for fluorescently-labeled beads in confocal and depletion imaging modes. Depletion imaging was also able to display a change of 2.2 to 2.9 ns for different regions of the cellular actin network of cultured cells with a possible difference in lifetime caused by tryptophan quenching of the dye. Subdiffraction imaging with a resolution of ≈40 nm was also accomplished using luminescence depletion of photostable giant CdSe/14CdS nanocrystal quantum dots in air. Nanocrystal quantum dots, typically not prone to depletion, exhibited this phenomenon when excited with an energy of 50 pJ and 2 nJ of depletion energy. Luminescence depletion required half the energy compared to stimulated emission depletion to achieve the same resolution limit. The luminescence was depleted by as much as ≈92% with no observable photobleaching. Raman measurements of polymer films were performed with 532-nm laser illumination using scanning angle and conventional 180° backscattering modes to determine chemical information. The scanning angle mode achieved an angle resolution of 0.09° and was used to probe a thin layer of polystyrene as well as a diblock copolymer of polystyrene and poly(3-hexylthiophene-2,5-diyl). Enhancements to the Raman signals at selected angles lower than the critical angle for total internal reflection

  18. Link Alpha E

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Electricity Markets and Policy Electricity: Standby Power ... Environmental Management System Environmental Report for Laboratory Site Environmental Restoration Program Equal Employment ...

  19. Multilevel DC link inverter

    DOEpatents

    Su, Gui-Jia

    2003-06-10

    A multilevel DC link inverter and method for improving torque response and current regulation in permanent magnet motors and switched reluctance motors having a low inductance includes a plurality of voltage controlled cells connected in series for applying a resulting dc voltage comprised of one or more incremental dc voltages. The cells are provided with switches for increasing the resulting applied dc voltage as speed and back EMF increase, while limiting the voltage that is applied to the commutation switches to perform PWM or dc voltage stepping functions, so as to limit current ripple in the stator windings below an acceptable level, typically 5%. Several embodiments are disclosed including inverters using IGBT's, inverters using thyristors. All of the inverters are operable in both motoring and regenerating modes.

  20. Link Alpha H

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Hands-on Universe (HOU) Program Harassment Prevention and Harassment Complaint Process HARP Hazard Management System (HMS) Hazardous Waste Requisition Health Services at the Lab...

  1. Link Alpha B

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Access at the Lab Building Emergency Team Building Managers Building Technology and Urban Systems Division (ETA) Buildings: Ventilation & Infiltration Buses: Lab Shuttle Bus...

  2. Link Alpha P

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Particle Adventure: A Tour of the Atom & Tools for Discovery Particle Data Group (PDG) Password Reset Patent Group Payroll Department (CFO) PDSF: Parallel Distributed Systems ...

  3. Biological hydrogen photoproduction

    SciTech Connect

    Nemoto, Y.

    1995-09-01

    Following are the major accomplishments of the 6th year`s study of biological hydrogen photoproduction which were supported by DOE/NREL. (1) We have been characterizing a biological hydrogen production system using synchronously growing aerobically nitrogen-fixing unicellular cyanobacterium, Synechococcus sp. Miami BG 043511. So far it was necessary to irradiate the cells to produce hydrogen. Under darkness they did not produce hydrogen. However, we found that, if the cells are incubated with oxygen, they produce hydrogen under the dark. Under 80% argon + 20% oxygen condition, the hydrogen production activity under the dark was about one third of that under the light + argon condition. (2) Also it was necessary so far to incubate the cells under argon atmosphere to produce hydrogen in this system. Argon treatment is very expensive and should be avoided in an actual hydrogen production system. We found that, if the cells are incubated at a high cell density and in a container with minimum headspace, it is not necessary to use argon for the hydrogen production. (3) Calcium ion was found to play an important role in the mechanisms of protection of nitrogenase from external oxygen. This will be a clue to understand the reason why the hydrogen production is so resistant to oxygen in this strain. (4) In this strain, sulfide can be used as electron donor for the hydrogen production. This result shows that waste water can be used for the hydrogen production system using this strain.

  4. Work with Biological Materials

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    cells, viruses), plant or soil samples (USDA quarantines), recombinant DNA, or blood-borne pathogen. Biological Use Authorization The great majority of biological work at...

  5. Plant Vascular Biology 2010

    SciTech Connect

    Ding, Biao

    2014-11-17

    This grant supported the Second International Conference on Plant Vascular Biology (PVB 2010) held July 24-28, 2010 on the campus of Ohio State University, Columbus, Ohio. Biao Ding (Ohio State University; OSU) and David Hannapel (Iowa State University; ISU) served as co-chairs of this conference. Biao Ding served as the local organizer. PVB is defined broadly here to include studies on the biogenesis, structure and function of transport systems in plants, under conditions of normal plant growth and development as well as of plant interactions with pathogens. The transport systems cover broadly the xylem, phloem, plasmodesmata and vascular cell membranes. The PVB concept has emerged in recent years to emphasize the integrative nature of the transport systems and approaches to investigate them.

  6. Links | National Nuclear Security Administration

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Links | National Nuclear Security Administration Facebook Twitter Youtube Flickr RSS People Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy...

  7. Linking Humans and Systems in Nuclear Power

    SciTech Connect

    Jacques Hugo

    2013-02-01

    Traditional engineering methods do not make provision for the integration of human considerations, while traditional human factors methods do not scale well to the complexity of large-scale nuclear power plant projects. Although the need for up-to-date human factors engineering processes and tools is recognised widely in industry, so far no formal guidance has been developed. This article proposes such a framework.

  8. Helpful Links - Hanford Site

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Help Solve Solar's Big Challenge Help Solve Solar's Big Challenge December 2, 2013 - 1:00pm Addthis Soft costs now account for more than 60% of the total price of installing residential solar energy systems. <a href="http://www.energy.gov/eere/articles/infographic-lets-get-work-solar-soft-costs">View the full infographic to learn more</a>. Soft costs now account for more than 60% of the total price of installing residential solar energy systems. View the full infographic to

  9. Reversibly immobilized biological materials in monolayer films on electrodes

    DOEpatents

    Weaver, P.F.; Frank, A.J.

    1993-05-04

    Methods and techniques are described for reversibly binding charged biological particles in a fluid medium to an electrode surface. The methods are useful in a variety of applications. The biological materials may include microbes, proteins, and viruses. The electrode surface may consist of reversibly electroactive materials such as polyvinylferrocene, silicon-linked ferrocene or quinone.

  10. Reversibly immobilized biological materials in monolayer films on electrodes

    DOEpatents

    Weaver, Paul F. (Golden, CO); Frank, Arthur J. (Lakewood, CO)

    1993-01-01

    Methods and techniques are described for reversibly binding charged biological particles in a fluid medium to an electrode surface. The methods are useful in a variety of applications. The biological materials may include microbes, proteins, and viruses. The electrode surface may consist of reversibly electroactive materials such as polyvinylferrocene, silicon-linked ferrocene or quinone.

  11. Major Conformed Contract Links | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Conformed Contract Links Major Conformed Contract Links Links to conformed copies of EM's major contracts. Major Conformed Contract Links (302.59 KB) More Documents & Publications Small Business Program Manager Directory EM Major Procurements DOE-Idaho Operations Office

  12. AlumniLink: June 2014

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    issues All Issues submit IN THIS ISSUE New science Neutrons provide new insights into human cell behavior Physics and biology intersect in breakthroughs Metallic glass could...

  13. MAJOR CONFORMED CONTRACTS LINKS Site/Project Contract Link Idaho

    Office of Environmental Management (EM)

    MAJOR CONFORMED CONTRACTS LINKS Site/Project Contract Link Idaho Idaho Cleanup Project http://www.id.doe.gov/doeid/ICPContract/ICPContract.htm Advance Mixed Waste Treatment http://www.id.energy.gov/doeid/AMWTPContract/AMWTPcontract.htm Oak Ridge http://science.energy.gov/isc/foia/electronic-reading-room/#MajorContractsAwarded Office of River Protection http://www.hanford.gov/page.cfm/DOE-ORPPrimeContracts EMCBC and Small Sites https://www.emcbc.doe.gov/About/PrimeContracts Richland

  14. Multiple weak-link SQUID

    SciTech Connect

    Kroger, H.

    1980-09-23

    The disclosed SQUID (Superconducting quantum interference device) comprises two superposed superconductive layers with an insulating layer therebetween. A plurality of holes through the insulating layer filled with superconductive material form weak links between the superconductive layers. One or more control lines superposed with respect to the superconductive layers provide magnetic flux through the area between the weak links to control the zero voltage supercurrent flowing through the weak links from one of the superconductive layers to the other thereby providing the switching function for Josephson superconductive circuits.

  15. LTS Related Links - Hanford Site

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Related Links About Us LTS Home Page LTS Project Management LTS Transition and Timeline LTS Execution LTS Background LTS Information Management LTS Fact Sheets / Briefings LTS In The News LTS Related Links LTS Contact Us LTS Related Links Email Email Page | Print Print Page | Text Increase Font Size Decrease Font Size Hanford Site Cleanup Completion Framework (DOE/RL 2009-10) (PDF) Hanford Long-Term Stewardship Program Plan (DOE/RL 2010-35) (PDF) DOE-EM LTS Site Legacy Management CERCLA 5 Year

  16. Cross-linked structure of network evolution

    SciTech Connect

    Bassett, Danielle S.; Wymbs, Nicholas F.; Grafton, Scott T.; Porter, Mason A.; Mucha, Peter J.

    2014-03-15

    We study the temporal co-variation of network co-evolution via the cross-link structure of networks, for which we take advantage of the formalism of hypergraphs to map cross-link structures back to network nodes. We investigate two sets of temporal network data in detail. In a network of coupled nonlinear oscillators, hyperedges that consist of network edges with temporally co-varying weights uncover the driving co-evolution patterns of edge weight dynamics both within and between oscillator communities. In the human brain, networks that represent temporal changes in brain activity during learning exhibit early co-evolution that then settles down with practice. Subsequent decreases in hyperedge size are consistent with emergence of an autonomous subgraph whose dynamics no longer depends on other parts of the network. Our results on real and synthetic networks give a poignant demonstration of the ability of cross-link structure to uncover unexpected co-evolution attributes in both real and synthetic dynamical systems. This, in turn, illustrates the utility of analyzing cross-links for investigating the structure of temporal networks.

  17. Electrostatic thin film chemical and biological sensor

    DOEpatents

    Prelas, Mark A.; Ghosh, Tushar K.; Tompson, Jr., Robert V.; Viswanath, Dabir; Loyalka, Sudarshan K.

    2010-01-19

    A chemical and biological agent sensor includes an electrostatic thin film supported by a substrate. The film includes an electrostatic charged surface to attract predetermined biological and chemical agents of interest. A charge collector associated with said electrostatic thin film collects charge associated with surface defects in the electrostatic film induced by the predetermined biological and chemical agents of interest. A preferred sensing system includes a charge based deep level transient spectroscopy system to read out charges from the film and match responses to data sets regarding the agents of interest. A method for sensing biological and chemical agents includes providing a thin sensing film having a predetermined electrostatic charge. The film is exposed to an environment suspected of containing the biological and chemical agents. Quantum surface effects on the film are measured. Biological and/or chemical agents can be detected, identified and quantified based on the measured quantum surface effects.

  18. Neutron instrumentation for biology

    SciTech Connect

    Mason, S.A.

    1994-12-31

    In the October 1994 round of proposals at the ILL, the external biology review sub- committee was asked to allocate neutron beam time to a wide range of experiments, on almost half the total number of scheduled neutron instruments: on 3 diffractometers, on 3 small angle scattering instruments, and on some 6 inelastic scattering spectrometers. In the 3.5 years since the temporary reactor shutdown, the ILL`s management structure has been optimized, budgets and staff have been trimmed, the ILL reactor has been re-built, and many of the instruments up-graded, many powerful (mainly Unix) workstations have been introduced, and the neighboring European Synchrotron Radiation Facility has established itself as the leading synchrotron radiation source and has started its official user program. The ILL reactor remains the world`s most intense dedicated neutron source. In this challenging context, it is of interest to review briefly the park of ILL instruments used to study the structure and energetics of small and large biological systems. A brief summary will be made of each class of experiments actually proposed in the latest ILL proposal round.

  19. NREL: Energy Analysis - Related Links

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Related Links Here you'll find links to other programs, organizations, and information resources concerning other analysis capabilities, energy-modeling, and technology expertise related to renewable energy. International Applications NREL's International Program in its effort to promote the use of renewable energy as a tool for sustainable development, applies world-class expertise in technology development and deployment, economic analysis, resource assessment, project design and

  20. Related Links | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Related Links Related Links Private, public, and nonprofit organizations around the country offer a wide range of courses and other services to help you either improve your current skills or learn new ones. The sites featured here can help you find courses of specific interest as well as other information about training requirements for certain energy jobs. DOE Related Advanced Manufacturing Office: Training Find training sessions in your area and learn how to save energy in your manufacturing

  1. Overview of How to Compile and Link | Argonne Leadership Computing...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    code for the BGQ system is too complex to cover in this document. What follows is a brief summary. All compile and link procedures are performed on login nodes with a ...

  2. Alternative Fuels Data Center: Hydrogen Related Links

    Alternative Fuels and Advanced Vehicles Data Center

    Hydrogen Printable Version Share this resource Send a link to Alternative Fuels Data Center: Hydrogen Related Links to someone by E-mail Share Alternative Fuels Data Center: Hydrogen Related Links on Facebook Tweet about Alternative Fuels Data Center: Hydrogen Related Links on Twitter Bookmark Alternative Fuels Data Center: Hydrogen Related Links on Google Bookmark Alternative Fuels Data Center: Hydrogen Related Links on Delicious Rank Alternative Fuels Data Center: Hydrogen Related Links on

  3. Alternative Fuels Data Center: Propane Related Links

    Alternative Fuels and Advanced Vehicles Data Center

    Propane Printable Version Share this resource Send a link to Alternative Fuels Data Center: Propane Related Links to someone by E-mail Share Alternative Fuels Data Center: Propane Related Links on Facebook Tweet about Alternative Fuels Data Center: Propane Related Links on Twitter Bookmark Alternative Fuels Data Center: Propane Related Links on Google Bookmark Alternative Fuels Data Center: Propane Related Links on Delicious Rank Alternative Fuels Data Center: Propane Related Links on Digg Find

  4. Khovanov homology of graph-links

    SciTech Connect

    Nikonov, Igor M

    2012-08-31

    Graph-links arise as the intersection graphs of turning chord diagrams of links. Speaking informally, graph-links provide a combinatorial description of links up to mutations. Many link invariants can be reformulated in the language of graph-links. Khovanov homology, a well-known and useful knot invariant, is defined for graph-links in this paper (in the case of the ground field of characteristic two). Bibliography: 14 titles.

  5. Structural Molecular Biology, SSRL

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Molecular Biology Group hosted a 3-day comprehensive workshop on the use of non-crystalline small-angle x-ray scattering and diffraction techniques in structural biology research. ...

  6. Links

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Related Sites National Nanotechnology Initiative Nano Technology Industries Advanced Materials Research Institute Institute of Physics Max-Planck Institute for Kohlenforschung The ...

  7. Links

    Energy.gov [DOE]

    More Legal Research ResourcesEnergy Law NetLegal Citation Style GuideNuclear Regulatory LegislationOpen CRSPublic Library of LawTreatiesU.S. Code Classification TablesU.S. Congressional Documents...

  8. ElectraLink | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    ElectraLink Jump to: navigation, search Name: ElectraLink Place: London, United Kingdom Product: London-based ElectraLink specialises in technology to communicate data between the...

  9. Alternative Fuels Data Center: Electricity Related Links

    Alternative Fuels and Advanced Vehicles Data Center

    Electricity Printable Version Share this resource Send a link to Alternative Fuels Data Center: Electricity Related Links to someone by E-mail Share Alternative Fuels Data Center: Electricity Related Links on Facebook Tweet about Alternative Fuels Data Center: Electricity Related Links on Twitter Bookmark Alternative Fuels Data Center: Electricity Related Links on Google Bookmark Alternative Fuels Data Center: Electricity Related Links on Delicious Rank Alternative Fuels Data Center: Electricity

  10. BizLink Technology | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    BizLink Technology Jump to: navigation, search Name: BizLink Technology Place: Fremont, California Zip: 94538 Sector: Solar Product: California-based manufacturer of solar modules,...

  11. Useful Links - Combustion Energy Frontier Research Center

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    FAQ Useful Links Useful Links Detailed campus map with CEFRC summer school buildings highlighted (NEW) Schedule of Events (NEW) Campus Map with CEFRC-specific buildings...

  12. Guiding Documents and Links | Department of Energy

    Office of Environmental Management (EM)

    Guiding Documents and Links Guiding Documents and Links Federal Executive Order 13653, Preparing the United States for the Impacts of Climate Change Executive Order 13693, Planning ...

  13. Help:Linked images | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Linked images Redirect page Jump to: navigation, search REDIRECT Manual:Linked images Retrieved from "http:en.openei.orgwindex.php?titleHelp:Linkedimages&oldid58478" ...

  14. Tobacco mosaic virus: A biological building block for micro/nano...

    Office of Scientific and Technical Information (OSTI)

    Tobacco mosaic virus: A biological building block for micronanobio systems Citation Details In-Document Search Title: Tobacco mosaic virus: A biological building block for micro...

  15. Biological tracer method

    DOEpatents

    Strong-Gunderson, J.M.; Palumbo, A.V.

    1998-09-15

    The present invention is a biological tracer method for characterizing the movement of a material through a medium, comprising the steps of: introducing a biological tracer comprising a microorganism having ice nucleating activity into a medium; collecting at least one sample of the medium from a point removed from the introduction point; and analyzing the sample for the presence of the biological tracer. The present invention is also a method for using a biological tracer as a label for material identification by introducing a biological tracer having ice nucleating activity into a material, collecting a sample of a portion of the labelled material and analyzing the sample for the presence of the biological tracer. 2 figs.

  16. Biological tracer method

    DOEpatents

    Strong-Gunderson, Janet M. (Ten Mile, TN); Palumbo, Anthony V. (Oak Ridge, TN)

    1998-01-01

    The present invention is a biological tracer method for characterizing the movement of a material through a medium, comprising the steps of: introducing a biological tracer comprising a microorganism having ice nucleating activity into a medium; collecting at least one sample of the medium from a point removed from the introduction point; and analyzing the sample for the presence of the biological tracer. The present invention is also a method for using a biological tracer as a label for material identification by introducing a biological tracer having ice nucleating activity into a material, collecting a sample of a portion of the labelled material and analyzing the sample for the presence of the biological tracer.

  17. Biological detector and method

    DOEpatents

    Sillerud, Laurel; Alam, Todd M.; McDowell, Andrew F.

    2015-11-24

    A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.

  18. Biological detector and method

    DOEpatents

    Sillerud, Laurel; Alam, Todd M; McDowell, Andrew F

    2013-02-26

    A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.

  19. Biological detector and method

    DOEpatents

    Sillerud, Laurel; Alam, Todd M; McDowell, Andrew F

    2014-04-15

    A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.

  20. Structural Molecular Biology, SSRL

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Our Mission Our Mission The SSRL Structural Molecular Biology program operates as a integrated resource and has three primary areas (or cores) of technological research and ...

  1. EIA - Natural Gas Pipeline Network - Regional Overview and Links

    Energy Information Administration (EIA) (indexed site)

    Overview and Links About U.S. Natural Gas Pipelines - Transporting Natural Gas based on data through 2007/2008 with selected updates Regional Overviews and Links to Pipeline Companies Through a series of interconnecting interstate and intrastate pipelines the transportation of natural gas from one location to another within the United States has become a relatively seamless operation. While intrastate pipeline systems often transports natural gas from production areas directly to consumers in

  2. Computational Biology: A Recipe for Ligand-Binding Proteins

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Computational Biology: A Recipe for Ligand-Binding Proteins Authors: Ghirlanda, G. Title: Computational Biology: A Recipe for Ligand-Binding Proteins Source: Nature Year: 2013 Volume: 501 Pages: 177-178 ABSTRACT: Cellular cross-talk, enzymatic catalysis and regulation of gene expression all depend on molecular recognition. A method that allows the design of proteins with desired recognition sites could thus be revolutionary Date of online publication: Thu, 2013-09-12 Link online:

  3. Integrated Biological Control

    SciTech Connect

    JOHNSON, A.R.

    2002-09-01

    Biological control is any activity taken to prevent, limit, clean up, or remediate potential environmental, health and safety, or workplace quality impacts from plants, animals, or microorganisms. At Hanford the principal emphasis of biological control is to prevent the transport of radioactive contamination by biological vectors (plants, animals, or microorganisms), and where necessary, control and clean up resulting contamination. Other aspects of biological control at Hanford include industrial weed control (e.g.; tumbleweeds), noxious weed control (invasive, non-native plant species), and pest control (undesirable animals such as rodents and stinging insects; and microorganisms such as molds that adversely affect the quality of the workplace environment). Biological control activities may be either preventive (apriori) or in response to existing contamination spread (aposteriori). Surveillance activities, including ground, vegetation, flying insect, and other surveys, and apriori control actions, such as herbicide spraying and placing biological barriers, are important in preventing radioactive contamination spread. If surveillance discovers that biological vectors have spread radioactive contamination, aposteriori control measures, such as fixing contamination, followed by cleanup and removal of the contamination to an approved disposal location are typical response functions. In some cases remediation following the contamination cleanup and removal is necessary. Biological control activities for industrial weeds, noxious weeds and pests have similar modes of prevention and response.

  4. Integrated Biological Control

    SciTech Connect

    JOHNSON, A.R.

    2003-10-09

    Biological control is any activity taken to prevent, limit, clean up, or remediate potential environmental, health and safety, or workplace quality impacts from plants, animals, or microorganisms. At Hanford the principal emphasis of biological control is to prevent the transport of radioactive contamination by biological vectors (plants, animals, or microorganisms), and where necessary, control and clean up resulting contamination. Other aspects of biological control at Hanford include industrial weed control (e.g.; tumbleweeds), noxious weed control (invasive, non-native plant species), and pest control (undesirable animals such as rodents and stinging insects, and microorganisms such as molds that adversely affect the quality of the workplace environment). Biological control activities may be either preventive (a priori) or in response to existing contamination spread (a posteriori). Surveillance activities, including ground, vegetation, flying insect, and other surveys, and a priori control actions, such as herbicide spraying and placing biological barriers, are important in preventing radioactive contamination spread. If surveillance discovers that biological vectors have spread radioactive contamination, a posteriori control measures, such as fixing contamination, followed by cleanup and removal of the contamination to an approved disposal location are typical response functions. In some cases remediation following the contamination cleanup and removal is necessary. Biological control activities for industrial weeds, noxious weeds and pests have similar modes of prevention and response.

  5. Cyclotron Institute » Journal Links

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Journal Links Acta Physica Polonica A Acta Physica Polonica B LANL e-Print Archive Nuclear Experiment Nuclear Theory Accelerator Physics Atomic Physics American Physical Society Physical Review A Physical Review C Physical Review D Physical Review Letters Reviews of Modern Physics Institute of Physics Journal of Physics B: Atomic, Molecular and Optical Physics Journal of Physics G: Nuclear and Particle Physics American Institute of Physics Applied Physics Letters Physics Today Nuclear Physics A

  6. Join our highlighted LinkedIn discussion

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Join our highlighted LinkedIn discussion Alumni Link: Opportunities, News and Resources for Former Employees Latest Issue:September 2015 all issues All Issues » submit Join our highlighted LinkedIn discussion What experiences have alumni had in software releases and deployments at different institutions? March 1, 2015 Robert Jilek Robert Jilek Contact Linda Anderman Email alumni LinkedIn Join us for a variety of discussions on the Lab's LinkedIn Alumni page What experiences have alumni had in

  7. Join our highlighted LinkedIn discussion

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Join our highlighted LinkedIn discussion Alumni Link: Opportunities, News and Resources for Former Employees Latest Issue:September 2015 all issues All Issues » submit Join our highlighted LinkedIn discussion Congratulations to LANL's Claudia Mora for being selected president elect of the Geological Society of America! July 1, 2015 Claudia Mora Claudia Mora Contact Linda Anderman Email alumni LinkedIn Join us for a variety of discussions on the Lab's LinkedIn Alumni page Congratulations to

  8. Biological sample collector

    DOEpatents

    Murphy, Gloria A.

    2010-09-07

    A biological sample collector is adapted to a collect several biological samples in a plurality of filter wells. A biological sample collector may comprise a manifold plate for mounting a filter plate thereon, the filter plate having a plurality of filter wells therein; a hollow slider for engaging and positioning a tube that slides therethrough; and a slide case within which the hollow slider travels to allow the tube to be aligned with a selected filter well of the plurality of filter wells, wherein when the tube is aligned with the selected filter well, the tube is pushed through the hollow slider and into the selected filter well to sealingly engage the selected filter well and to allow the tube to deposit a biological sample onto a filter in the bottom of the selected filter well. The biological sample collector may be portable.

  9. Topics: Uncovering the physics of magnetic self-organization and links to

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    astrophysics - MST - UW Plasma Physics Uncovering the physics of magnetic self-organization and links to astrophysics UW Madison Madison Symmetric Torus Topics: Uncovering the physics of magnetic self-organization and links to astrophysics MST HomeGraduate Student InformationLinksTourControl and Auxiliary SystemsPhysics TopicsDeviceResearch MissionMST People mst logo CPLA Home Directory Publications Links Internal University of Wisconsin Physics Department Research funding includes support

  10. SciTech Connect: Website Policies / Important Links

    Office of Scientific and Technical Information (OSTI)

    Website Policies Important Links Website Policies Important Links Javascript Not Enabled OSTI Security Website Policies and Important Links

  11. SciTech Connect: Website Policies / Important Links

    Office of Scientific and Technical Information (OSTI)

    Website Policies / Important Links Website Policies / Important Links Javascript Not Enabled OSTI Security Website Policies and Important Links

  12. Reference Links | U.S. DOE Office of Science (SC)

    Office of Science (SC)

    Act External link DOJ Office of Information and Privacy External link Defense Nuclear Facilities Safety Board External link Government Printing Office External link National ...

  13. Biological Macromolecular Structures Data from the RCSB Protein Data Bank (RCSB PDB)

    DOE Data Explorer

    The Research Collaboratory for Structural Bioinformatics (RCSB) is a non-profit consortium that works to improve understanding of the function of biological systems through the study of the 3-D structure of biological macromolecules. The RCSB PDB is one of three sites serving as deposition, data processing, and distribution sites of the Protein Data Bank Archive. Each site provides its own view of the primary data, thus providing a variety of tools and resources for the global community. RCSB is also the official keeper for the PDB archive, with sole access authority to the PDB archive directory structure and contents. The RCSB PDB Information Portal for Biological Macromolecular Structures offers online tools for search and retrieval, for visualizing structures, for depositing, validating, or downloading data, news and highlights, a discussion forum, and links to other areas of related research. The PDB archive is a repository of atomic coordinates and other information describing proteins and other important biological macromolecules. Structural biologists use methods such as X-ray crystallography, NMR spectroscopy, and cryo-electron microscopy to determine the location of each atom relative to each other in the molecule. They then deposit this information, which is then annotated and publicly released into the archive by the wwPDB. Results can be viewed as 3-D images or models.

  14. 2013 Biological Hydrogen Production Workshop Summary Report | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energy Biological Hydrogen Production Workshop Summary Report 2013 Biological Hydrogen Production Workshop Summary Report November 2013 summary report for the 2013 Biological Hydrogen Production Workshop. bio_h2_workshop_final_report.pdf (1.55 MB) More Documents & Publications The Hydrogen Program at NREL: A Brief Overview Hydrogenases and Barriers for Biotechnological Hydrogen Production Technologies Renewable Hydrogen Production from Biological Systems

  15. Technoeconomic Boundary Analysis of Biological Pathways to Hydrogen Production

    SciTech Connect

    James, B. D.; Baum, G. N.; Perez, J.; Baum, K. N.

    2009-09-01

    Report documenting the biological and engineering characteristics of five algal and bacterial hydrogen production systems selected by DOE and NREL for evaluation.

  16. Technoeconomic Boundary Analysis of Biological Pathways to Hydrogen Production

    Energy.gov [DOE]

    Report documenting the biological and engineering characteristics of five algal and bacterial hydrogen production systems selected by DOE and NREL for evaluation.

  17. March 2014 Most Viewed Documents for Biology And Medicine | OSTI...

    Office of Scientific and Technical Information (OSTI)

    March 2014 Most Viewed Documents for Biology And Medicine Carbon Dioxide Sequestering Using Microalgal Systems Daniel J. Stepan; Richard E. Shockey; Thomas A. Moe; Ryan Dorn (2002) ...

  18. July 2013 Most Viewed Documents for Biology And Medicine | OSTI...

    Office of Scientific and Technical Information (OSTI)

    July 2013 Most Viewed Documents for Biology And Medicine Carbon Dioxide Sequestering Using Microalgal Systems Daniel J. Stepan; Richard E. Shockey; Thomas A. Moe; Ryan Dorn (2002) ...

  19. Characterization and reactivity of the weakly bound complexes of the [H, N, S]{sup −} anionic system with astrophysical and biological implications

    SciTech Connect

    Trabelsi, T.; Ajili, Y.; Ben Yaghlane, S.; Jaidane, N.-E.; Mogren Al-Mogren, M.; Francisco, J. S.; Hochlaf, M.

    2015-07-21

    We investigate the lowest electronic states of doublet and quartet spin multiplicity states of HNS{sup −} and HSN{sup −} together with their parent neutral triatomic molecules. Computations were performed using highly accurate ab initio methods with a large basis set. One-dimensional cuts of the full-dimensional potential energy surfaces (PESs) along the interatomic distances and bending angle are presented for each isomer. Results show that the ground anionic states are stable with respect to the electron detachment process and that the long range parts of the PESs correlating to the SH{sup −} + N, SN{sup −} + H, SN + H{sup −}, NH + S{sup −}, and NH{sup −} + S are bound. In addition, we predict the existence of long-lived weakly bound anionic complexes that can be formed after cold collisions between SN{sup −} and H or SH{sup −} and N. The implications for the reactivity of these species are discussed; specifically, it is shown that the reactions involving SH{sup −}, SN{sup −}, and NH{sup −} lead either to the formation of HNS{sup −} or HSN{sup −} in their electronic ground states or to autodetachment processes. Thus, providing an explanation for why the anions, SH{sup −}, SN{sup −}, and NH{sup −}, have limiting detectability in astrophysical media despite the observation of their corresponding neutral species. In a biological context, we suggest that HSN{sup −} and HNS{sup −} should be incorporated into H{sub 2}S-assisted heme-catalyzed reduction mechanism of nitrites in vivo.

  20. Biological Hydrogen Production Workshop

    Energy.gov [DOE]

    The U.S. Department of Energy's (DOE's) National Renewable Energy Laboratory (NREL) held a Biological Hydrogen Production Workshop on September 24–25, 2013, in Golden, Colorado. The workshop...

  1. Universal Biology, the Genetic

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Universal Biology, the Genetic Code and the First Billion Years of Life on Earth Nigel Goldenfeld University of Illinois May 25, 2016 4:00 p.m. - Wilson Hall, One West This ...

  2. Work with Biological Materials

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Work with Biological Materials Print Planning A complete Experiment Safety Sheet (ESS) is required before work can be done at the ALS. This ESS is either a part of the proposal...

  3. Micro/nanofabricated environments for synthetic biology

    SciTech Connect

    Collier, Pat [ORNL; Simpson, Michael L [ORNL

    2011-01-01

    A better understanding of how confinement, crowding and reduced dimensionality modulate reactivity and reaction dynamics will aid in the rational and systematic discovery of functionality in complex biological systems. Artificial micro- and nanofabricated structures have helped elucidate the effects of nanoscale spatial confinement and segregation on biological behavior, particularly when integrated with microfluidics, through precise control in both space and time of diffusible signals and binding interactions. Examples of nanostructured interfaces for synthetic biology include the development of cell-like compartments for encapsulating biochemical reactions, nanostructured environments for fundamental studies of diffusion, molecular transport and biochemical reaction kinetics, and regulation of biomolecular interactions as functions of micro- and nanofabricated topological constraints.

  4. Structural Molecular Biology, SSRL

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Toggle navigation SMB Home Mission Facilities Macromolecular Crystallography Small Angle X-Ray Scattering X-Ray Spectroscopy & Imaging User Resources User Resources User Portal Schedules Deadlines Highlights Training Workshops & Summer Schools Summer Students Structural Molecular Biology Illuminating Biological Structures at the Atomic and Molecular Levels Your browser does not support the video tag. SMB Mission SSRL's SMB program operates as an integrated resource and has three cores of

  5. Useful Links for Small Businesses | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Useful Links for Small Businesses Useful Links for Small Businesses Business USA A product of collective thoughts and inputs from the following agencies who have pledged their commitment to making this site a one-stop shop for everything related to business in the USA. Electronic Subcontracting Reporting System (eSRS) This is the official site for the electronic Subcontracting Reporting System (eSRS). The use of eSRS promises to create higher visibility and introduce a more transparency into the

  6. Molecular Mechanism of Biological Proton Transport

    SciTech Connect

    Pomes, R.

    1998-09-01

    Proton transport across lipid membranes is a fundamental aspect of biological energy transduction (metabolism). This function is mediated by a Grotthuss mechanism involving proton hopping along hydrogen-bonded networks embedded in membrane-spanning proteins. Using molecular simulations, the authors have explored the structural, dynamic, and thermodynamic properties giving rise to long-range proton translocation in hydrogen-bonded networks involving water molecules, or water wires, which are emerging as ubiquitous H{sup +}-transport devices in biological systems.

  7. Link Force Holdings Ltd | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    search Name: Link Force Holdings Ltd Place: China Product: China-based energy saving LED street light maker. References: Link Force Holdings Ltd1 This article is a stub. You...

  8. linked open data | OpenEI Community

    OpenEI (Open Energy Information) [EERE & EIA]

    linked open data Home Jweers's picture Submitted by Jweers(88) Contributor 10 October, 2012 - 08:20 LOD Workshop Invitation Event linked open data LOD Open Data workshop Update the...

  9. Tunable Thermal Link - Energy Innovation Portal

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Tunable Thermal Link Lawrence Berkeley National Laboratory Contact LBL About This Technology Technology Marketing SummaryThermal links are incorporated into everything from frying pans to internal combustion engine spark plugs and heat sinks on integrated circuit boards. Typically, the link's thermal resistance is fixed and cannot be tuned after manufacture. While the ability to tune electrical resistors is widespread, virtually no tunable thermal resistance link exists, which has held back the

  10. E-print Network Website Policies and Important Links -- Energy...

    Office of Scientific and Technical Information (OSTI)

    Website Policies Important Links Javascript Not Enabled OSTI Security Website Policies and Important Links

  11. Track with overlapping links for dry coal extrusion pumps

    DOEpatents

    Saunders, Timothy; Brady, John D

    2014-01-21

    A chain for a particulate material extrusion pump includes a plurality of links, each of the plurality of links having a link body and a link ledge, wherein each link ledge of the plurality of links at least partially overlaps the link body of an adjacent one of the plurality of links.

  12. 2015 Aser links | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Aser links 2015 Aser links Annual Site Environmental Reports (ASER); Sites; contacts; email 2015 ASER links (94.62 KB) More Documents & Publications DOE Annual Site Environmental Reports (ASER) 2010 Annual Site Environmental Report (ASER) Supplement 2011 Annual Site Environmental Report (ASER) Supplement

  13. Michael Levitt and Computational Biology

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Biology Resources with Additional Information * Publications Michael Levitt Courtesy of Linda A. Cicero Stanford News Service Michael Levitt, PhD, professor of structural biology ...

  14. Biological Applications of Synchrotron Radiation:

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    A BioSync Report. Issued by the Structural Biology Synchrotron users Organization, ... of those beams has had a major impact on many areas of science, including biology. ...

  15. Green Biologics | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Biologics Jump to: navigation, search Name: Green Biologics Place: Oxfordshire, United Kingdom Sector: Biomass, Renewable Energy Product: Oxfordshire-based industrial biotech...

  16. Other Links | U.S. DOE Office of Science (SC)

    Office of Science (SC)

    Other Links Print Text Size: A A A FeedbackShare Page DOE Directives PARS II Defense Acq. University External link CII External link EFCOG External link PMI External link Last ...

  17. Generation and characterization of biological aerosols for laser measurements

    SciTech Connect

    Cheng, Yung-Sung; Barr, E.B.

    1995-12-01

    Concerns for proliferation of biological weapons including bacteria, fungi, and viruses have prompted research and development on methods for the rapid detection of biological aerosols in the field. Real-time instruments that can distinguish biological aerosols from background dust would be especially useful. Sandia National Laboratories (SNL) is developing a laser-based, real-time instrument for rapid detection of biological aerosols, and ITRI is working with SNL scientists and engineers to evaluate this technology for a wide range of biological aerosols. This paper describes methods being used to generate the characterize the biological aerosols for these tests. In summary, a biosafe system has been developed for generating and characterizing biological aerosols and using those aerosols to test the SNL laser-based real-time instrument. Such tests are essential in studying methods for rapid detection of airborne biological materials.

  18. Join our highlighted LinkedIn discussion

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Join our highlighted LinkedIn discussion Alumni Link: Opportunities, News and Resources for Former Employees Latest Issue:September 2015 all issues All Issues » submit Join our highlighted LinkedIn discussion Do you use social media when at conferences? November 1, 2014 Robert Jilek Robert Jilek Contact Linda Anderman Email alumni LinkedIn Join us for a variety of discussions on the Lab's LinkedIn Alumni page Do you use social media when at conferences? We are fascinated by this question and

  19. Join our highlighted LinkedIn discussion

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Join our highlighted LinkedIn discussion Alumni Link: Opportunities, News and Resources for Former Employees Latest Issue:September 2015 all issues All Issues » submit Join our highlighted LinkedIn discussion Top science stories of 2014 from Los Alamos National Lab January 1, 2015 Robert Jilek Robert Jilek Contact Linda Anderman Email alumni LinkedIn Join us for a variety of discussions on the Lab's LinkedIn Alumni page Top science stories of 2014 from Los Alamos National Lab What was your

  20. E-Link - User Account

    Office of Scientific and Technical Information (OSTI)

    information defines the type of access and various other data relationships in the system. ... in accordance with the accessdistribution limitation provided in the Announcement Notice. ...

  1. AlumniLink: September 2014

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    at Los Alamos National Laboratory New high-performance computer system, called Wolf, will be used for unclassified research Alumni spotlight Robert Jilek: Pellion ...

  2. Biological response modifiers

    SciTech Connect

    Weller, R.E.

    1991-10-01

    Much of what used to be called immunotherapy is now included in the term biological response modifiers. Biological response modifiers (BRMs) are defined as those agents or approaches that modify the relationship between the tumor and host by modifying the host's biological response to tumor cells with resultant therapeutic effects.'' Most of the early work with BRMs centered around observations of spontaneous tumor regression and the association of tumor regression with concurrent bacterial infections. The BRM can modify the host response in the following ways: Increase the host's antitumor responses through augmentation and/or restoration of effector mechanisms or mediators of the host's defense or decrease the deleterious component by the host's reaction; Increase the host's defenses by the administration of natural biologics (or the synthetic derivatives thereof) as effectors or mediators of an antitumor response; Augment the host's response to modified tumor cells or vaccines, which might stimulate a greater response by the host or increase tumor-cell sensitivity to an existing response; Decrease the transformation and/or increase differentiation (maturation) of tumor cells; or Increase the ability of the host to tolerate damage by cytotoxic modalities of cancer treatment.

  3. Feedstock Supply System Design and Economics for Conversion of Lignocellulosic Biomass to Hydrocarbon Fuels: Conversion Pathway: Biological Conversion of Sugars to Hydrocarbons The 2017 Design Case

    SciTech Connect

    Kevin Kenney; Kara G. Cafferty; Jacob J. Jacobson; Ian J Bonner; Garold L. Gresham; William A. Smith; David N. Thompson; Vicki S. Thompson; Jaya Shankar Tumuluru; Neal Yancey

    2013-09-01

    The U.S. Department of Energy promotes the production of a range of liquid fuels and fuel blendstocks from lignocellulosic biomass feedstocks by funding fundamental and applied research that advances the state of technology in biomass collection, conversion, and sustainability. As part of its involvement in this program, the Idaho National Laboratory (INL) investigates the feedstock logistics economics and sustainability of these fuels. Between 2000 and 2012, INL conducted a campaign to quantify the economics and sustainability of moving biomass from standing in the field or stand to the throat of the biomass conversion process. The goal of this program was to establish the current costs based on conventional equipment and processes, design improvements to the current system, and to mark annual improvements based on higher efficiencies or better designs. The 2012 programmatic target was to demonstrate a delivered biomass logistics cost of $35/dry ton. This goal was successfully achieved in 2012 by implementing field and process demonstration unit-scale data from harvest, collection, storage, preprocessing, handling, and transportation operations into INL’s biomass logistics model. Looking forward to 2017, the programmatic target is to supply biomass to the conversion facilities at a total cost of $80/dry ton and on specification with in-feed requirements. The goal of the 2017 Design Case is to enable expansion of biofuels production beyond highly productive resource areas by breaking the reliance of cost-competitive biofuel production on a single, abundant, low-cost feedstock. If this goal is not achieved, biofuel plants are destined to be small and/or clustered in select regions of the country that have a lock on low-cost feedstock. To put the 2017 cost target into perspective of past accomplishments of the cellulosic ethanol pathway, the $80 target encompasses total delivered feedstock cost, including both grower payment and logistics costs, while meeting all

  4. Methods for isolation and viability assessment of biological organisms

    DOEpatents

    Letant, Sonia Edith; Baker, Sarah Elyse; Bond, Tiziana; Chang, Allan Shih-Ping

    2015-02-03

    Isolation of biological or chemical organisms can be accomplished using a surface enhanced Raman scattering (SERS) system. The SERS system can be a single or a stacked plurality of photonic crystal membranes with noble-metal lined through pores for flowing analyte potentially containing the biological or chemical organisms. The through pores can be adapted to trap individual biological or chemical organisms and emit SERS spectra, which can then be detected by a detector and further analyzed for viability of the biological or chemical organism.

  5. Fuel Cells Related Links | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Fuel Cells » Fuel Cells Related Links Fuel Cells Related Links The following resources provide details about U.S. Department of Energy (DOE)-funded fuel cell activities, research plans and roadmaps, partnerships, and additional related links. DOE-Funded Fuel Cell Activities Each year, hydrogen and fuel cell projects funded by DOE's Hydrogen and Fuel Cells Program are reviewed for their merit during an Annual Merit Review and Peer Evaluation Meeting. View posters and presentations from the

  6. Hydrogen Delivery Related Links | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Delivery » Hydrogen Delivery Related Links Hydrogen Delivery Related Links The following resources provide details about U.S. Department of Energy (DOE)-funded hydrogen delivery activities, research plans and roadmaps, models and tools, and additional related links. DOE-Funded Hydrogen Delivery Activities Each year, hydrogen and fuel cell projects funded by DOE's Hydrogen and Fuel Cells Program are reviewed for their merit during an Annual Merit Review and Peer Evaluation Meeting. View posters

  7. Hydrogen Production Related Links | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Production Related Links Hydrogen Production Related Links The following resources provide details about U.S. Department of Energy (DOE)-funded hydrogen production activities, research plans and roadmaps, models and tools, and additional related links. DOE-Funded Hydrogen Production Activities Each year, hydrogen and fuel cell projects funded by DOE's Hydrogen and Fuel Cells Program are reviewed for their merit during an Annual Merit Review and Peer Evaluation Meeting. View posters and

  8. Hydrogen Storage Related Links | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Related Links Hydrogen Storage Related Links The following resources provide details about U.S. Department of Energy (DOE)-funded hydrogen storage activities, research plans and roadmaps, models and tools, and additional related links. DOE-Funded Hydrogen Storage Activities Each year, hydrogen and fuel cell projects funded by DOE's Hydrogen and Fuel Cells Program are reviewed for their merit during an Annual Merit Review and Peer Evaluation Meeting. View posters and presentations from the latest

  9. Join our highlighted LinkedIn discussion

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Join our highlighted LinkedIn discussion Alumni Link: Opportunities, News and Resources for Former Employees Latest Issue:September 2015 all issues All Issues » submit Join our highlighted LinkedIn discussion Descartes Labs is using deep learning technology developed at LANL to help us better understand our world May 1, 2015 The site offers a variety of Los Alamos-developed biosurveillance tools that can be used for decision support in disease surveillance. The site offers a variety of Los

  10. The versatile link, a common project for super-LHC

    SciTech Connect

    Amaral, Luis; Dris, Stefanos; Gerardin, Alexandre; Huffman, Todd; Issever, Cigdem; Pacheco, Alberto Jimenez; Jones, Mark; Kwan, Simon; Lee, Shih-Chang; Lian, Zhijun; Liu, Tiankuan; /CERN /Oxford U. /Fermilab /Taipei, Computing Ctr. /Southern Methodist U.

    2009-07-01

    Radiation tolerant, high speed optoelectronic data transmission links are fundamental building blocks in today's large scale High Energy Physics (HEP) detectors, as exemplified by the four experiments currently under commissioning at the Large Hadron Collider (LHC), see for example. New experiments or upgrades will impose even more stringent demands on these systems from the point of view of performance and radiation tolerance. This can already be seen from the developments underway for the Super Large Hadron Collider (SLHC) project, a proposed upgrade to the LHC aiming at increasing the luminosity of the machine by factor of 10 to 10{sup 35} cm{sup -2}s{sup -1}, and thus providing a better chance to see rare processes and improving statistically marginal measurements. In the past, specific data transmission links have been independently developed by each LHC experiment for data acquisition (DAQ), detector control as well as trigger and timing distribution (TTC). This was justified by the different types of applications being targeted as well as by technological limitations preventing one single solution from fitting all requirements. However with today's maturity of optoelectronic and CMOS technologies it is possible to envisage the development of a general purpose optical link which can cover most transmission applications: a Versatile Link. Such an approach has the clear advantage of concentrating the development effort on one single project targeting an optical link whose final functionality will only result from the topology and configuration settings adopted.

  11. Related Links | U.S. DOE Office of Science (SC)

    Office of Science (SC)

    Association for Computing Machinery External link Computing Research Association External link International Exascale Software Project External link Last modified: 352016 7:59:23

  12. Fusion Links | U.S. DOE Office of Science (SC)

    Office of Science (SC)

    Fusion Facilities and Personnel Directory External link Fusion Power Associates External link Institute of Electrical and Electronic Engineers External link International Tokamak ...

  13. DOE - NNSA/NFO -- Policies and Important Links

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Website Policies and Important Links NNSANFO Language Options U.S. DOENNSA - Nevada Field Office Website Policies and Important Links Privacy Policy FOIA Important Links Privacy ...

  14. Former Worker Medical Screening Program Related Documents & Links...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Related Documents & Links Former Worker Medical Screening Program Related Documents & Links Related Documents & Links Beryllium Information-ORISE Chronic Beryllium Disease ...

  15. OSTIblog Articles in the reference linking Topic | OSTI, US Dept...

    Office of Scientific and Technical Information (OSTI)

    reference linking Topic OSTI and Reference Linking by Daphne Evans 13 May, 2008 in Technology OSTI actively supports the practice of Reference Linking. Also referred to as citation ...

  16. WaikatoLink Limited | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Limited Jump to: navigation, search Name: WaikatoLink Limited Place: New Zealand Sector: Services Product: General Financial & Legal Services ( Individual Angel network )...

  17. Linked Energy Data | OpenEI

    OpenEI (Open Energy Information) [EERE & EIA]

    traditional web provides interlinked documents that are designed for humans to read, the web of Linked Data provides interlinked data that is designed to be processed by software...

  18. Biological particle identification apparatus

    DOEpatents

    Salzman, Gary C.; Gregg, Charles T.; Grace, W. Kevin; Hiebert, Richard D.

    1989-01-01

    An apparatus and method for making multiparameter light scattering measurements from suspensions of biological particles is described. Fourteen of the sixteen Mueller matrix elements describing the particles under investigation can be substantially individually determined as a function of scattering angle and probing radiations wavelength, eight elements simultaneously for each of two apparatus configurations using an apparatus which incluees, in its simplest form, two polarization modulators each operating at a chosen frequency, one polarizer, a source of monochromatic electromagnetic radiation, a detector sensitive to the wavelength of radiation employed, eight phase-sensitive detectors, and appropriate electronics. A database of known biological particle suspensions can be assembled, and unknown samples can be quickly identified once measurements are performed on it according to the teachings of the subject invention, and a comparison is made with the database.

  19. BIOLOGICAL IRRADIATION FACILITY

    DOEpatents

    McCorkle, W.H.; Cern, H.S.

    1962-04-24

    A facility for irradiating biological specimens with neutrons is described. It includes a reactor wherein the core is off center in a reflector. A high-exposure room is located outside the reactor on the side nearest the core while a low-exposure room is located on the opposite side. Means for converting thermal neutrons to fast neutrons are movably disposed between the reactor core and the high and low-exposure rooms. (AEC)

  20. Report of The Structural Biology Subcommittee of The Biological and

    Office of Science (SC)

    Environmental Research Advisory Committee | U.S. DOE Office of Science (SC) Report of The Structural Biology Subcommittee of The Biological and Environmental Research Advisory Committee Biological and Environmental Research Advisory Committee (BERAC) BERAC Home Meetings Members Charges/Reports Current BERAC Charges Archive of BERAC Reports Charter .pdf file (135KB) BER Committees of Visitors Federal Advisory Committees BER Home Charges/Reports Report of The Structural Biology Subcommittee of

  1. Impact of Radiation Biology on Fundamental Insights in Biology

    DOE R&D Accomplishments

    Setlow, Richard B.

    1982-07-27

    Research supported by OHER [Office of Health and Environmental Research] and its predecessors has as one of its major goals an understanding of the effects of radiation at low doses and dose rates on biological systems, so as to predict their effects on humans. It is not possible to measure such effects directly. They must be predicted from basic knowledge on how radiation affects cellular components such as DNA and membranes and how cells react to such changes. What is the probability of radiation producing human mutations and what are the probabilities of radiation producing cancer? The end results of such studies are radiation exposure standards for workers and for the general population. An extension of these goals is setting standards for exposure to chemicals involved in various energy technologies. This latter problem is much more difficult because chemical dosimetry is a primitive state compared to radiation dosimetry.

  2. Impact of Radiation Biology on Fundamental in Biology

    SciTech Connect

    Setlow, Richard B.

    1983-01-20

    Research supported by OHER and its predecessors has as one of its major goals an understanding of the effects of radiation at low doses and dose rates on biological systems, so as to predict their effects on humans. It is not possible to measure such effects directly. They must be predicted from basic knowledge on how radiation affects cellular components such as DNA and membranes and how cells react to such changes. What is the probability of radiation producing human mutations and what are the probabilities of radiation producing cancer? The end results of such studies are radiation exposure standards for workers and for the general population. An extension of these goals is setting standards for exposure to chemicals involved in various energy technologies. This latter problem is much more difficult because chemical dosimetry is is a primitive state compared to radiation dosimetry.

  3. Systems Biology Knowledgebase (GSC8 Meeting)

    ScienceCinema

    Cottingham, Robert W [ORNL

    2016-07-12

    The Genomic Standards Consortium was formed in September 2005. It is an international, open-membership working body which promotes standardization in the description of genomes and the exchange and integration of genomic data. The 2009 meeting was an activity of a five-year funding "Research Coordination Network" from the National Science Foundation and was organized held at the DOE Joint Genome Institute with organizational support provided by the JGI and by the University of California - San Diego. Robert W. Cottingham of Oak Ridge National Laboratory discusses the DOE KnowledgeBase at the Genomic Standards Consortium's 8th meeting at the DOE JGI in Walnut Creek, Calif. on Sept. 9, 2009.

  4. Biological Systems for Hydrogen Photoproduction (Poster)

    SciTech Connect

    Ghirardi, M.; King, P.; Maness, P. C.; Seibert, M.

    2006-05-01

    Presented at the 2006 DOE Hydrogen, Fuel Cells & Infrastructure Technologies Program Annual Merit Review in Washington, D.C., May 16-19, 2006.

  5. Modular microfluidic system for biological sample preparation...

    Office of Scientific and Technical Information (OSTI)

    module, c) a dielectrophoresis virus filter module, d) an isotachophoresis nucleic acid filter module, e) a lyses module, and f) an isotachophoresis-based nucleic acid filter. ...

  6. California Valley Solar Ranch Biological Assessment | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    California Valley Solar Ranch Biological Assessment California Valley Solar Ranch Biological Assessment Biological Assessment for the California Valley Solar Ranch Project San Luis Obispo County, California High Plains Ranch II, LLC (HPR II), a wholly owned subsidiary of SunPower Corporation, Systems ("SunPower") proposes to construct a 250-megawatt (MW) solar photovoltaic (PV) energy plant, the California Valley Solar Ranch Project (CVSR Project or Project), on a 4,747acre site in

  7. Property:Incentive/Auth7Link | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Auth7Link Jump to: navigation, search Property Name IncentiveAuth7Link Property Type URL Description Url link to authority. Pages using the property "IncentiveAuth7Link" Showing...

  8. Property:Incentive/Auth9Link | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Auth9Link Jump to: navigation, search Property Name IncentiveAuth9Link Property Type URL Description Url link to authority. Pages using the property "IncentiveAuth9Link" Showing...

  9. Property:Incentive/Auth11Link | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    1Link Jump to: navigation, search Property Name IncentiveAuth11Link Property Type URL Description Url link to authority Pages using the property "IncentiveAuth11Link" Showing 20...

  10. Abengoa Mojave Final Biological Opinion

    Energy.gov [DOE]

    Biological Opinion on Mojave Solar, LLC's Mojave Solar Project, San Bernardino County, California (8-8-11-F-3)

  11. Responses of Cell Renewal Systems to Long-term Low-Level Radiation Exposure: A Feasibility Study Applying Advanced Molecular Biology Techniques on Available Histological and Cytological Material of Exposed Animals and Men

    SciTech Connect

    Fliedner Theodor M.; Feinendegen Ludwig E.; Meineke Viktor; Fritz Thomas E.

    2005-02-28

    First results of this feasibility study showed that evaluation of the stored material of the chronically irradiated dogs with modern molecular biological techniques proved to be successful and extremely promising. Therefore an in deep analysis of at least part of the huge amount of remaining material is of outmost interest. The methods applied in this feasibility study were pathological evaluation with different staining methods, protein analysis by means of immunohistochemistry, strand break analysis with the TdT-assay, DNA- and RNA-analysis as well as genomic examination by gene array. Overall more than 50% of the investigated material could be used. In particular the results of an increased stimulation of the immune system within the dogs of the 3mSv group as both compared to the control and higher dose groups gives implications for the in depth study of the cellular events occurring in context with low dose radiation. Based on the findings of this study a further evaluation and statistically analysis of more material can help to identify promising biomarkers for low dose radiation. A systematic evaluation of a correlation of dose rates and strand breaks within the dog tissue might moreover help to explain mechanisms of tolerance to IR. One central problem is that most sequences for dog specific primers are not known yet. The discovery of the dog genome is still under progress. In this study the isolation of RNA within the dog tissue was successful. But up to now there are no gene arrays or gene chips commercially available, tested and adapted for canine tissue. The uncritical use of untested genomic test systems for canine tissue seems to be ineffective at the moment, time consuming and ineffective. Next steps in the investigation of genomic changes after IR within the stored dog tissue should be limited to quantitative RT-PCR of tested primer sequences for the dog. A collaboration with institutions working in the field of the discovery of the dog genome could

  12. Elements in biological AMS

    SciTech Connect

    Vogel, J.S.; McAninch, J.; Freeman, S.

    1996-08-01

    AMS (Accelerator Mass Spectrometry) provides high detection sensitivity for isotopes whose half-lives are between 10 years and 100 million years. {sup 14}C is the most developed of such isotopes and is used in tracing natural and anthropogenic organic compounds in the Earth`s biosphere. Thirty-three elements in the main periodic table and 17 lanthanides or actinides have long lived isotopes, providing potential tracers for research in elemental biochemistry. Overlap of biologically interesting heavy elements and possible AMS tracers is discussed.

  13. Biological Performance Assessment

    Energy Science and Technology Software Center

    2013-07-09

    The BioPA provides turbine designers with a set of tools that can be used to assess biological risks of turbines during the design phase, before expensive construction begins. The toolset can also be used to assess existing installations under a variety of operating conditions, supplementing data obtained through expensive field testing. The BioPA uses computational fluid dynamics (CFD) simulations of a turbine design to quantify the exposure of passing fish to a set of knownmore » injury mechanisms. By appropriate sampling of the fluid domain, the BioPA assigns exposure probabilities to each mechanism. The exposure probabilities are combined with dose-response data from laboratory stress studies of fish to produce a set of biological BioPA Scores. These metrics provide an objective measure that can be used to compare competing turbines or to refine a new design. The BioPA process can be performed during the turbine design phase and is considerably less expensive than prototype-scale field testing.« less

  14. Jonathan Link, Columbia NuCosmo '02

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    7-19, 2002 Jonathan Link, Columbia NuCosmo '02 Jonathan Link Columbia University Workshop on Neutrino News from the Lab and the Cosmos October 17-19, 2002 October 17-19, 2002 Jonathan Link, Columbia NuCosmo '02 Outline 1. The LSND Experiment a. The experimental setup b. Results c. Ramifications 2. MiniBooNE a. The BooNE Collaboration b. The beam line and expected neutrino flux c. The MiniBooNE detector d. Expected backgrounds and systematics e. First neutrino events, and cosmic rays f.

  15. Jonathan Link, Columbia KEK Topical Conference

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    -22, 2001 Jonathan Link, Columbia KEK Topical Conference Short Baseline Neutrino Oscillations and MiniBooNE Jonathan Link Columbia University The 5 th KEK Topical Conference - Frontiers in Flavor Physics November 20-22, 2001 November 20-22, 2001 Jonathan Link, Columbia KEK Topical Conference Outline 1. Background on Short Baseline Neutrino Oscillations * A little neutrino physics * The LSND oscillation result 2. About MiniBooNE 3. Status of MiniBooNE. Some of you may have noticed that I'll be

  16. Privacy Act Links to Related Sites | National Nuclear Security

    National Nuclear Security Administration (NNSA)

    Administration | (NNSA) Links to Related Sites The Privacy Act of 1974 (Title 5, United States Code, Section 552a). The Federal Register is the official daily publication for Rules, Proposed Rules, and Notices of Federal agencies and organizations, as well as Executive Orders and other Presidential Documents. The Privacy Act Issuances Compilation contains descriptions of Federal agency systems of records maintained on individuals and rules agencies follow to assist individuals who request

  17. 2013 Biological Hydrogen Production Workshop Summary Report ...

    Energy Saver

    Biological Hydrogen Production Workshop Summary Report 2013 Biological Hydrogen Production Workshop Summary Report November 2013 summary report for the 2013 Biological Hydrogen ...

  18. Biological Lignin Depolymerization Presentation for BETO 2015...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    depolymerization with new synthetic biology techniques and new process concepts in biological funneling High-Level Objective: * Employ biology for depolymerization and aromatic ...

  19. Highly cross-linked nanoporous polymers

    DOEpatents

    Steckle, Jr., Warren P.; Apen, Paul G.; Mitchell, Michael A.

    1998-01-01

    Condensation polymerization followed by a supercritical extraction step can be used to obtain highly cross-linked nanoporous polymers with high surface area, controlled pore sizes and rigid structural integrity. The invention polymers are useful for applications requiring separation membranes.

  20. Highly cross-linked nanoporous polymers

    DOEpatents

    Steckle, Jr., Warren P.; Apen, Paul G.; Mitchell, Michael A.

    1997-01-01

    Condensation polymerization followed by a supercritical extraction step can be used to obtain highly cross-linked nanoporous polymers with high surface area, controlled pore sizes and rigid structural integrity. The invention polymers are useful for applications requiring separation membranes.

  1. OpenEI and Linked Open Data

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ... in the last two years alone." -IBM, 2012 (http:www-01.ibm.comsoftwaredatabigdata) 13 Open Energy Information http:en.openei.org LINKED OPEN DATA AT WORK Behind The Scenes, ...

  2. OpenEI Community - linked open data

    OpenEI (Open Energy Information) [EERE & EIA]

    linked-open-data-workshop-washington-dc

  3. Fuel Cell Technologies Manufacturing Related Links

    Energy.gov [DOE]

    The following resources provide details about U.S. Department of Energy-funded fuel cell technologies manufacturing activities, other EERE and federal manufacturing activities and initiatives, research plans and roadmaps, workshops, and additional related links.

  4. Environmental Justice Links | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Links Environmental Justice Links Public Information Center DOE Library U.S. Department of Health and Human Services (HHS), National Health Information Center U.S. Department of Health and Human Services (HHS), Office of Minority Health Resource Center U.S. Department of Housing and Urban Development Online Library U.S. Department of Interior Library U.S. Department of Labor Library U.S. Department of Transportation (DOT) Library U.S. Environmental Protection Agency Library Services for the

  5. Links for Scientists and Researchers | Jefferson Lab

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Links for Scientists and Researchers Below you will find links commonly used by scientists, users and others who conduct research at Jefferson Lab. Experimental Areas Hall A Hall B Hall C Hall D Other Work Areas Physics Division Work Planning Requirements Physics Division Work Governance Area Access for Students Training requirements for experimental areas Nuclear Physics Program Physics Home Page Experiment Schedule Three-Year Accelerator Schedule Program Advisory Committee (PAC) Experiment

  6. Thermochemical Conversion Related Links | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Conversion » Thermochemical Conversion Related Links Thermochemical Conversion Related Links Further reading about current Bioenergy Technologies Office R&D in the Thermochemical Platform can be found in this website's Information Resources section. Some key publications are: Biomass Conversion: From Feedstocks to Final Products (July 2016) Thermochemical Conversion 2009 Peer Review Design Case Summary: Production of Gasoline and Diesel from Biomass via Fast Pyrolysis, Hydrotreating, and

  7. Archived Links: International EERE | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Archived Links: International EERE Archived Links: International EERE Below you may view and download the archived Success Stories / Fact Sheets from International EERE: Accelerating the Clean Energy Transition in South Africa (May 28, 2015) Fact Sheet: Accelerating the Deployment of Energy Efficiency & Renewable Energy in South Africa (May 27, 2015) Sustainable Energy for Remote Indonesian Grids Explores Opportunities in Stakeholder Workshop (October 15, 2014) Mapping Opportunities for U.S.

  8. Related Links | National Nuclear Security Administration | (NNSA)

    National Nuclear Security Administration (NNSA)

    Related Links NNSA and Other Related Links DOE/NNSA Phonebook Freedom of Information Act Department of Energy DOE Directives DOE Jobs Online Defense Nuclear Facilities Safety Board DOE Pulse Publication DOE Office of Health, Safety and Security USA.Gov Los Alamos County Los Alamos National Laboratory LANL Phonebook National Nuclear Security Administration NNSA Service Center - Albuquerque NNSA Nevada Field Office New Mexico Environmental Department - LANL Sandia National Laboratories Waste

  9. System Analysis Success Stories | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    System Analysis Success Stories System Analysis Success Stories Program Links System Analysis Success Stories Economic Impact Tools National Geothermal Data System (NGDS) Initiative

  10. Control design of Santo Tome back-to-back HVDC link

    SciTech Connect

    Rostamkolai, N.; Wegner, C.A.; Piwko, R.J.; Elahi, H.; Eitzmann, M.A. ); Garzi, G.; Tietz, P. )

    1993-08-01

    This paper describes the control design of the Santo tome' back-to-back HVDC link. The Santo Tome' HVDC converter will be the second dc link asynchronously connecting the Argentina and Brazil power systems. This paper focuses on the design of the reactive power control, automatic power control, load frequency control, power modulation control, automatic frequency control, and automatic synchronizing control functions of the 50 MW dc link. Time simulation and frequency domain results are included to illustrate the system response and verify the adequacy of the controllers performance in achieving stable operating conditions.

  11. Biochemical Process Improvements & Synthetic Biology Validation...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Process Improvements & Synthetic Biology Validation Projects This presentation ... Develop efficient, inexpensive synthetic biology methods and tools to convert biomass into ...

  12. Biological Safety | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Biological Select Agents Inspection Report: IG-0681, Concerns Regarding a Non-Viable (Dead) "Anthrax Sport" Research Project at the Oak Ridge National Laboratory Inspection ...

  13. Biological & Environmental Research Abstracts Database

    Office of Scientific and Technical Information (OSTI)

    Welcome to the Biological and Environmental Research Abstracts Database The U.S. ... This database contains abstracts of research projects supported by the program. Work was ...

  14. Links - Plasma Couette Experiment - Cary Forest Group - UW Plasma Physics

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Links UW Madison Plasma Couette Experiment Links PCX HomeResearch MissionPhysics TopicsDeviceDiagnosticsContacts LinksPCX People CPLA Home Directory Publications Links University of Wisconsin Physics Department Department of Energy National Science Foundation No links yet

  15. Real time markerless motion tracking using linked kinematic chains

    DOEpatents

    Luck, Jason P.; Small, Daniel E.

    2007-08-14

    A markerless method is described for tracking the motion of subjects in a three dimensional environment using a model based on linked kinematic chains. The invention is suitable for tracking robotic, animal or human subjects in real-time using a single computer with inexpensive video equipment, and does not require the use of markers or specialized clothing. A simple model of rigid linked segments is constructed of the subject and tracked using three dimensional volumetric data collected by a multiple camera video imaging system. A physics based method is then used to compute forces to align the model with subsequent volumetric data sets in real-time. The method is able to handle occlusion of segments and accommodates joint limits, velocity constraints, and collision constraints and provides for error recovery. The method further provides for elimination of singularities in Jacobian based calculations, which has been problematic in alternative methods.

  16. Biological effectiveness of neutrons: Research needs

    SciTech Connect

    Casarett, G.W.; Braby, L.A.; Broerse, J.J.; Elkind, M.M.; Goodhead, D.T.; Oleinick, N.L.

    1994-02-01

    The goal of this report was to provide a conceptual plan for a research program that would provide a basis for determining more precisely the biological effectiveness of neutron radiation with emphasis on endpoints relevant to the protection of human health. This report presents the findings of the experts for seven particular categories of scientific information on neutron biological effectiveness. Chapter 2 examines the radiobiological mechanisms underlying the assumptions used to estimate human risk from neutrons and other radiations. Chapter 3 discusses the qualitative and quantitative models used to organize and evaluate experimental observations and to provide extrapolations where direct observations cannot be made. Chapter 4 discusses the physical principles governing the interaction of radiation with biological systems and the importance of accurate dosimetry in evaluating radiation risk and reducing the uncertainty in the biological data. Chapter 5 deals with the chemical and molecular changes underlying cellular responses and the LET dependence of these changes. Chapter 6, in turn, discusses those cellular and genetic changes which lead to mutation or neoplastic transformation. Chapters 7 and 8 examine deterministic and stochastic effects, respectively, and the data required for the prediction of such effects at different organizational levels and for the extrapolation from experimental results in animals to risks for man. Gaps and uncertainties in this data are examined relative to data required for establishing radiation protection standards for neutrons and procedures for the effective and safe use of neutron and other high-LET radiation therapy.

  17. Welcome to the First Issue of AlumniLink

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Welcome to the First Issue of AlumniLink A personal message from Lab Director Charlie McMillan June 20, 2014 First Issue of AlumniLink First Issue of AlumniLink Contact Linda...

  18. Hawaii Noise Forms and Links Webpage | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    and Links Webpage Jump to: navigation, search OpenEI Reference LibraryAdd to library Web Site: Hawaii Noise Forms and Links Webpage Abstract This webpage contains links to...

  19. Property:Incentive/Auth6Link | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Auth6Link Jump to: navigation, search Property Name IncentiveAuth6Link Property Type URL Pages using the property "IncentiveAuth6Link" Showing 25 pages using this property....

  20. Compiling and Linking | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Changes from Tukey to Cooley Compiling and Linking Using Cobalt on Cooley Visit on Cooley Paraview on Cooley ParaView Tutorial VNC on Cooley Policies Documentation Feedback Please provide feedback to help guide us as we continue to build documentation for our new computing resource. [Feedback Form] Compiling and Linking Compilers and MPI GNU compilers, version 4.4.7, are installed and are available in your default environment. To use version 4.8.1 of the GNU compilers instead, add +gcc-4.8.1 to

  1. Curing system for high voltage cross linked cables

    DOEpatents

    Bahder, George; Katz, Carlos; Bopp, Louis A.

    1978-01-01

    This invention makes extruded, vulcanized, high voltage cables insulated with thermosetting compounds at much higher rates of production and with superior insulation of reduced thickness and with reduced cavities or voids in the insulation. As the cable comes from an extruder, it passes into a curing chamber with a heat booster that quickly raises the insulation to a temperature at which it is cured much more quickly than with steam heating of the prior art. A high temperature liquid in contact with the insulation maintains the high temperature; and because of the greater curing heat, the cable can travel through the curing chamber at a faster rate and into a cooling tube where it contacts with a cooling liquid under high pressure. The insulation compound is treated to reduce the size of cavities; and the high pressure maintained by the curing and cooling mediums prevent expansion of cavities before the insulation is set.

  2. Links - Madison Dynamo Experiment - Cary Forest Group - UW Plasma Physics

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Links UW Madison Madison Dynamo Experiment Links MDE HomeLinksNewsBackgroundPublicationsPresentationsContactsMDE People CPLA Home Directory Publications Links University of Wisconsin Physics Department Department of Energy National Science Foundation Local Links Plasma Physics in the UW Physics Department The Department of Physics University of Wisconsin - Madison Dynamo Links Riga Dynamo Experiment Karlsruhe Dynamo Experiment The Von-Karman Sodium Experiment Grenoble Geodynamo Experiment

  3. Compiling with -ipo produces "unresolved" warning messages at link time on

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Cray systems Compiling with -ipo produces "unresolved" warning messages at link time on Cray systems Compiling with -ipo produces "unresolved" warning messages at link time on Cray systems November 18, 2013 by Mike Stewart, NERSC USG Status: Reported to the darshan developers. Updated June 12, 2015 by Scott French, NERSC USG Updated March 9, 2016 by Jialin Liu, NERSC DAS This bug affects our Cray systems Edison and Cori, and is still present as of March 2016. When a code

  4. ECOWAS Clean Energy Gateway-Links | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    ECOWAS Clean Energy Gateway-Links Jump to: navigation, search Economic Community of West African States (ECOWAS) Clean Energy Gateway Home | About | News | Links | Help | Countries...

  5. EIA - Natural Gas Pipeline Network - Regional Overview and Links

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Overview and Links About U.S. Natural Gas Pipelines - Transporting Natural Gas based on data through 20072008 with selected updates Regional Overviews and Links to Pipeline ...

  6. High PID Resistant Cross-Linked Encapsulnt Based on Polyolefin...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    PID Resistant Cross-Linked Encapsulnt Based on Polyolefin SOLAR ASCE High PID Resistant Cross-Linked Encapsulnt Based on Polyolefin SOLAR ASCE Presented at the PV Module ...

  7. Linking Advanced Visualization and MATLAB for the Analysis of...

    Office of Scientific and Technical Information (OSTI)

    Linking Advanced Visualization and MATLAB for the Analysis of 3D Gene Expression Data Citation Details In-Document Search Title: Linking Advanced Visualization and MATLAB for the ...

  8. Linking Legacies: Connecting the Cold War Nuclear Weapons Production...

    Office of Environmental Management (EM)

    Linking Legacies: Connecting the Cold War Nuclear Weapons Production Processes to Their Environmental Consequences Linking Legacies: Connecting the Cold War Nuclear Weapons ...

  9. Highly cross-linked nanoporous polymers

    DOEpatents

    Steckle, W.P. Jr.; Apen, P.G.; Mitchell, M.A.

    1998-01-20

    Condensation polymerization followed by a supercritical extraction step can be used to obtain highly cross-linked nanoporous polymers with high surface area, controlled pore sizes and rigid structural integrity. The invention polymers are useful for applications requiring separation membranes. 1 fig.

  10. Linked-View Parallel Coordinate Plot Renderer

    Energy Science and Technology Software Center

    2011-06-28

    This software allows multiple linked views for interactive querying via map-based data selection, bar chart analytic overlays, and high dynamic range (HDR) line renderings. The major component of the visualization package is a parallel coordinate renderer with binning, curved layouts, shader-based rendering, and other techniques to allow interactive visualization of multidimensional data.

  11. Thiazolothiazole-linked porous organic polymers

    SciTech Connect

    Zhu, Xiang; Tian, Chengcheng; Jin, Tian; Wang, Jitong; Mahurin, Shannon Mark; Mei, Wenwen; Xiong, Yan; Hu, Jun; Feng, Xinliang; Liu, Honglai; Dai, Sheng

    2014-10-07

    In this study, thiazolothiazole-linked porous organic polymers have been synthesized from a facile catalyst-free condensation reaction between aldehydes and dithiooxamide under solvothermal conditions. The resultant porous frameworks exhibit a highly selective uptake of CO2 over N2 under ambient conditions.

  12. Thiazolothiazole-linked porous organic polymers

    DOE PAGES [OSTI]

    Zhu, Xiang; Tian, Chengcheng; Jin, Tian; Wang, Jitong; Mahurin, Shannon Mark; Mei, Wenwen; Xiong, Yan; Hu, Jun; Feng, Xinliang; Liu, Honglai; et al

    2014-10-07

    In this study, thiazolothiazole-linked porous organic polymers have been synthesized from a facile catalyst-free condensation reaction between aldehydes and dithiooxamide under solvothermal conditions. The resultant porous frameworks exhibit a highly selective uptake of CO2 over N2 under ambient conditions.

  13. Acceptance Criteria Framework for Autonomous Biological Detectors

    SciTech Connect

    Dzenitis, J M

    2006-12-12

    The purpose of this study was to examine a set of user acceptance criteria for autonomous biological detection systems for application in high-traffic, public facilities. The test case for the acceptance criteria was the Autonomous Pathogen Detection System (APDS) operating in high-traffic facilities in New York City (NYC). However, the acceptance criteria were designed to be generally applicable to other biological detection systems in other locations. For such detection systems, ''users'' will include local authorities (e.g., facility operators, public health officials, and law enforcement personnel) and national authorities [including personnel from the Department of Homeland Security (DHS), the BioWatch Program, the Centers for Disease Control and Prevention (CDC), and the Federal Bureau of Investigation (FBI)]. The panel members brought expertise from a broad range of backgrounds to complete this picture. The goals of this document are: (1) To serve as informal guidance for users in considering the benefits and costs of these systems. (2) To serve as informal guidance for developers in understanding the needs of users. In follow-up work, this framework will be used to systematically document the APDS for appropriateness and readiness for use in NYC.

  14. A New Biology for the 21st Century; Ensuring the United States Leads the Coming Biology Revolution. Final committee report

    SciTech Connect

    None None

    2012-05-10

    In July, 2008, the National Institutes of Health (NIH), National Science Foundation (NSF), and Department of Energy (DOE) asked the National Research Council’s Board on Life Sciences to convene a committee to examine the current state of biological research in the United States and recommend how best to capitalize on recent technological and scientific advances that have allowed biologists to integrate biological research findings, collect and interpret vastly increased amounts of data, and predict the behavior of complex biological systems. From September 2008 through July of 2009, a committee of 16 experts from the fields of biology, engineering and computational science undertook to delineate those scientific and technological advances and come to a consensus on how the U.S. might best capitalize on them. This report, authored by the Committee on a New Biology for the 21st Century, describes the committee’s work and conclusions.

  15. Biology and Medicine Division annual report, 1987

    SciTech Connect

    Not Available

    1988-04-01

    Modern biology is characterized by rapid change. The development of new tools and the results derived from their application to various biological systems require significant shifts in our concepts and the strategies that are adopted to analyze and elucidate mechanisms. In parallel with exciting new scientific developments our organizational structure and programmatic emphases have altered. These changes and developments have enabled the life sciences at LBL to be better positioned to create and respond to new opportunities. The work summarized in this annual report reflects a vital multifaceted research program that is in the vanguard of the areas represented. We are committed to justifying the confidence expressed by LBL through the new mission statement and reorganizational changes designed to give greater prominence to the life sciences.

  16. 2011 Archaea: Ecology, Metabolism, & Molecular Biology

    SciTech Connect

    Keneth Stedman

    2011-08-05

    Archaea, one of three major evolutionary lineages of life, are a fascinating and diverse group of microbes with deep roots overlapping those of eukaryotes. The focus of the 'Archaea: Ecology Metabolism & Molecular Biology' GRC conference expands on a number of emerging topics highlighting new paradigms in archaeal metabolism, genome function and systems biology; information processing; evolution and the tree of life; the ecology and diversity of archaea and their viruses. The strength of this conference lies in its ability to couple a field with a rich history in high quality research with new scientific findings in an atmosphere of stimulating exchange. This conference remains an excellent opportunity for younger scientists to interact with world experts in this field.

  17. 2009 Archaea: Ecology, Metabolism & Molecular Biology GRC

    SciTech Connect

    Dr. Julie Maupin- Furlow

    2009-07-26

    Archaea, one of three major evolutionary lineages of life, are a fascinating and diverse group of microbes with deep roots overlapping those of eukaryotes. The focus of the 'Archaea: Ecology Metabolism & Molecular Biology' GRC conference expands on a number of emerging topics highlighting new paradigms in archaeal metabolism, genome function and systems biology; information processing; evolution and the tree of life; the ecology and diversity of archaea and their viruses; and industrial applications. The strength of this conference lies in its ability to couple a field with a rich history in high quality research with new scientific findings in an atmosphere of stimulating exchange. This conference remains an excellent opportunity for younger scientists to interact with world experts in this field.

  18. A fuzzy self-tuning PI controller for HVDC links

    SciTech Connect

    Routray, A.; Dash, P.K.; Panda, S.K.

    1996-09-01

    This paper introduces a fuzzy logic-based tuning of the controller parameters for the rectifier side current regulator and inverter side gamma controller in a high voltage direct current (HVDC) system. A typical point-to-point system has been taken with the detailed representation of converters, transmission links transformers, and filters. The current error and its derivative and the gamma error and its derivative are used as the principal signals to adjust the proportional and integral gains of the rectifier pole controller and the inverter gamma controller, respectively, for the optimum system performance under various normal and abnormal conditions. Finally, a comparative study has been performed with and without tuning, to prove the superiority of the proposed scheme.

  19. Detection and treatment of chemical weapons and/or biological pathogens

    DOEpatents

    Mariella Jr., Raymond P.

    2004-09-07

    A system for detection and treatment of chemical weapons and/or biological pathogens uses a detector system, an electrostatic precipitator or scrubber, a circulation system, and a control. The precipitator or scrubber is activated in response to a signal from the detector upon the detection of chemical weapons and/or biological pathogens.

  20. Merging hydraulics with biology

    SciTech Connect

    Thorncraft, Garry; Baumgartner, Lee J.; Boys, Craig A.; Brown, Richard S.

    2013-01-01

    Research staff are now working with developers in Lao PDR and Australia to ensure design criteria is optimised at time of construction. Research is presently underway on a suite of Mekong and Murray-Darling species to identify critical tolerances of shear and pressure. Work in the USA is also being expanded to lamprey and white sturgeon in an effort to increase the understanding beyond salmon species. Researchers and developers are hopeful of constructing the first fish-friendly hydro plants within the next two years. Pending favourable outcomes, the expansion of this technology to other sites and river systems is the ultimate development outcome.

  1. Biological Science | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Biological Science Biological Science The protozoan Plasmodium falciparum gliding through a cell in the gut of a mosquito, its primary host. Although five different species of Plasmodium can cause malaria, Plasmodium falciparum causes the most severe disease. | Photo courtesy of Wikipedia Commons. <a href="http://energy.gov/articles/malaria-researchers-find-weakness-global-killer">Read more</a> The protozoan Plasmodium falciparum gliding through a cell in the gut of a

  2. Biological and Environmental Research Network Requirements

    SciTech Connect

    Balaji, V.; Boden, Tom; Cowley, Dave; Dart, Eli; Dattoria, Vince; Desai, Narayan; Egan, Rob; Foster, Ian; Goldstone, Robin; Gregurick, Susan; Houghton, John; Izaurralde, Cesar; Johnston, Bill; Joseph, Renu; Kleese-van Dam, Kerstin; Lipton, Mary; Monga, Inder; Pritchard, Matt; Rotman, Lauren; Strand, Gary; Stuart, Cory; Tatusova, Tatiana; Tierney, Brian; Thomas, Brian; Williams, Dean N.; Zurawski, Jason

    2013-09-01

    The Energy Sciences Network (ESnet) is the primary provider of network connectivity for the U.S. Department of Energy (DOE) Office of Science (SC), the single largest supporter of basic research in the physical sciences in the United States. In support of SC programs, ESnet regularly updates and refreshes its understanding of the networking requirements of the instruments, facilities, scientists, and science programs that it serves. This focus has helped ESnet be a highly successful enabler of scientific discovery for over 25 years. In November 2012, ESnet and the Office of Biological and Environmental Research (BER) of the DOE SC organized a review to characterize the networking requirements of the programs funded by the BER program office. Several key findings resulted from the review. Among them: 1) The scale of data sets available to science collaborations continues to increase exponentially. This has broad impact, both on the network and on the computational and storage systems connected to the network. 2) Many science collaborations require assistance to cope with the systems and network engineering challenges inherent in managing the rapid growth in data scale. 3) Several science domains operate distributed facilities that rely on high-performance networking for success. Key examples illustrated in this report include the Earth System Grid Federation (ESGF) and the Systems Biology Knowledgebase (KBase). This report expands on these points, and addresses others as well. The report contains a findings section as well as the text of the case studies discussed at the review.

  3. Link failure detection in a parallel computer

    DOEpatents

    Archer, Charles J.; Blocksome, Michael A.; Megerian, Mark G.; Smith, Brian E.

    2010-11-09

    Methods, apparatus, and products are disclosed for link failure detection in a parallel computer including compute nodes connected in a rectangular mesh network, each pair of adjacent compute nodes in the rectangular mesh network connected together using a pair of links, that includes: assigning each compute node to either a first group or a second group such that adjacent compute nodes in the rectangular mesh network are assigned to different groups; sending, by each of the compute nodes assigned to the first group, a first test message to each adjacent compute node assigned to the second group; determining, by each of the compute nodes assigned to the second group, whether the first test message was received from each adjacent compute node assigned to the first group; and notifying a user, by each of the compute nodes assigned to the second group, whether the first test message was received.

  4. Links | National Nuclear Security Administration | (NNSA)

    National Nuclear Security Administration (NNSA)

    Links NNSA HQ National Nuclear Security Administration Advanced Simulation & Computing NNSA Graduate Program NNSA Small Business Program Office of Defense Nuclear Nonproliferation Field Offices NNSA Albuquerque Complex Kansas City Field Office Livermore Field Office Los Alamos Field Office Naval Reactors Idaho Branch Office Nevada Field Office Sandia Field Office DOE Oak Ridge Sites Oak Ridge Office Oak Ridge National Laboratory UCOR Oak Ridge Institute for Science and Education Oak Ridge

  5. Related Links | National Nuclear Security Administration | (NNSA)

    National Nuclear Security Administration (NNSA)

    Related Links NNSA Lab Directed Research and Development (LDRD) Lab Directed Research and Development Collaborations DOE Adanced Scientific Computing Research DTRA (Defense Threat Reduction Agency) NAS (National Academy of Sciences) NSF (National Science Foundation) DOD (Department of Defense) NASA Exascale Activities NNSA Exascale Environment Planning Workshop ASCR Co-Design Centers Supercomputing Top 500 List ASC at Supercomputing Conference General Information ASC at the Labs How ASC Supports

  6. Detection of biological molecules using chemical amplification and optical sensors

    DOEpatents

    Van Antwerp, William Peter; Mastrototaro, John Joseph

    2004-10-12

    Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.

  7. Detection of biological molecules using chemical amplification and optical sensors

    DOEpatents

    Van Antwerp, William Peter; Mastrototaro, John Joseph

    2000-01-01

    Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.

  8. Biological H{sub 2} from fuel gases and from H{sub 2}O

    SciTech Connect

    Weaver, P.; Maness, P.C.; Rhodes, C.; Scahill, J.; Dundorf, S.; Martin, S.

    1998-08-01

    The two stand-alone objectives of the research are to economically produce H{sub 2} in the near term from biomass (thermally gasified to syngas) and in the mid term from H{sub 2}O using cyanobacteria or algae with an oxygen-tolerant bacterial hydrogenase. Photosynthetic bacteria have four different terminal enzymes that mediate their H{sub 2} metabolisms--nitrogenase, uptake hydrogenase, fermentative hydrogenase, and carbon monoxide-linked hydrogenase. Each has been microbiologically and biochemically examined for their potential to specifically generate H{sub 2} in large-scale processes. Based on measurements of maximal activities, stabilities, energy requirements, equilibria, and partial pressures of the H{sub 2} producing reactions, the Co-linked hydrogenase is easily the most suited for practical applications. The enzyme mediates H{sub 2} production from CO at rates up to 3 mmol/min {center_dot} g cell dry weight at near ambient temperature and pressure. At biological temperatures, equilibrium for the CO shift into H{sub 2} lies far towards H{sub 2} production. Less than 0.1 ppm of CO remains after a 20% CO gas phase is acted upon by bacteria. The necessary contact time between CO and bacteria is approximately ten seconds. Similar biological activities are observed with thermally generated fuel gases. The product gas can be directly used in fuel cells. New bacterial isolates from nature and mutant strains are being selected to further improve the novel technology. Oxygen-resistant enzymes identified in some bacterial strains could lead to a more general, second generation technology mediating the solar production of H{sub 2} from H{sub 2}O. Presently, mass transfer of gaseous CO limits the bacterial production of H{sub 2} from fuel gases. New bioreactor designs have significantly enhanced shift rates. Vapor-phase and bubble-train bioreactors employing immobilized or suspended bacteria are being scaled up. A User Facility has been established for the safe

  9. Study of fibreoptic communication links with the optical regeneration of signals

    SciTech Connect

    Shtyrina, O V; Fedoruk, Mikhail P; Turitsyn, Sergei K

    2005-02-28

    Wavelength-division-multiplexing fibreoptic communication links with optical 2R regenerators based on a saturable absorber are mathematically simulated. The results of optimisation of specific configurations of symmetric lines are presented, and it is shown that the transmission distance in systems with the periodic optical regeneration of signals considerably exceeds that in systems without optical regenerators. (fibreoptic communication. waveguides)

  10. Power links with Ireland -- Excitation of turbine-generator shaft torsional vibrations by variable frequency currents superimposed on DC currents in asynchronous HVDC links

    SciTech Connect

    Hammons, T.J.; Tay, B.W.; Kok, K.L.

    1995-08-01

    The paper describes an in-depth analysis of excitation of shaft torsional vibrations in steam-turbine-generator-exciter shafts in close proximity to HVDC converter stations by variable-frequency ripple currents superimposed on the DC currents in asynchronous Links. It extends earlier work to include an in depth analysis of system scaling factors for harmonic currents impressed on generators in Northern Ireland by an inverter and to investigate the phenomena for possible torsional vibrations in the generators by the Link. Frequencies at which shaft torsional vibrations would be excited by modulation product harmonics in 50Hz/50Hz asynchronous Links as a function of deviation in system frequency is reviewed. Relative noncharacteristic current levels for 50Hz/50Hz connectors are illustrated assuming ripple currents at the inverter which gives realistic harmonic voltages in a twelve-pulse bridge. The paper then shows that torques in machines in multi-machine networks may be estimated by proportioning HVDC link harmonic disturbance current appropriately to each machine at risk. It is concluded that variable-frequency ripple currents superimposed on the DC current in asynchronous links can excite sympathetic torsional vibrations in turbine-generator-exciter shafts.

  11. Artificial photosynthesis combines biology with technology for...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    biology with technology for sustainable energy transformation Authors: Moore, T.A., Moore, A.L., and Gust, D. Title: Artificial photosynthesis combines biology with ...

  12. Repurposing the translation apparatus for synthetic biology ...

    Office of Scientific and Technical Information (OSTI)

    biology Citation Details In-Document Search This content will become publicly available on July 14, 2017 Title: Repurposing the translation apparatus for synthetic biology ...

  13. Innovative Breakthrough Demonstrated for Biological Ethanol Production...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Innovative Breakthrough Demonstrated for Biological Ethanol Production Innovative Breakthrough Demonstrated for Biological Ethanol Production June 30, 2015 - 11:43am Addthis ...

  14. eLink_2013.jpg | OSTI, US Dept of Energy Office of Scientific and Technical

    Office of Scientific and Technical Information (OSTI)

    Information eLink_2013

  15. Mapping N-linked Glycosylation Sites in the Secretome and Whole Cells of Aspergillus niger Using Hydrazide Chemistry and Mass Spectrometry

    SciTech Connect

    Wang, Lu; Aryal, Uma K.; Dai, Ziyu; Mason, Alisa C.; Monroe, Matthew E.; Tian, Zhixin; Zhou, Jianying; Su, Dian; Weitz, Karl K.; Liu, Tao; Camp, David G.; Smith, Richard D.; Baker, Scott E.; Qian, Weijun

    2012-01-01

    Protein glycosylation is known to play an essential role in both cellular functions and the secretory pathways; however, little information is available on the dynamics of glycosylated N-linked glycosites of fungi. Herein we present the first extensive mapping of glycosylated N-linked glycosites in industrial strain Aspergillus niger by applying an optimized solid phase enrichment of glycopeptide protocol using hydrazide modified magnetic beads. The enrichment protocol was initially optimized using mouse plasma and A. niger secretome samples, which was then applied to profile N-linked glycosites from both the secretome and whole cell lysates of A. niger. A total of 847 unique N-linked glycosites and 330 N-linked glycoproteins were confidently identified by LC-MS/MS. Based on gene ontology analysis, the identified N-linked glycoproteins in the whole cell lysate were primarily localized in the plasma membrane, endoplasmic reticulum, golgi apparatus, lysosome, and storage vacuoles. The identified N-linked glycoproteins are involved in a wide range of biological processes including gene regulation and signal transduction, protein folding and assembly, protein modification and carbohydrate metabolism. The extensive coverage of glycosylated N-linked glycosites along with identification of partial N-linked glycosylation in those enzymes involving in different biochemical pathways provide useful information for functional studies of N-linked glycosylation and their biotechnological applications in A. niger.

  16. Grays River Watershed and Biological Assessment, 2006 Final Report.

    SciTech Connect

    May, Christopher; Geist, David

    2007-04-01

    habitat conditions, and biological integrity. In addition, human land-use impacts are factored into the conceptual model because they can alter habitat quality and can disrupt natural habitat forming processes. In this model (Figure S.1), aquatic habitat--both instream and riparian--is viewed as the link between watershed conditions and biologic responses. Based on this conceptual model, assessment of habitat loss and the resultant declines in salmonid populations can be conducted by relating current and historical (e.g., natural) habitat conditions to salmonid utilization, diversity, and abundance. In addition, assessing disrupted ecosystem functions and processes within the watershed can aid in identifying the causes of habitat change and the associated decline in biological integrity. In this same way, restoration, enhancement, and conservation projects can be identified and prioritized. A watershed assessment is primarily a landscape-scale evaluation of current watershed conditions and the associated hydrogeomorphic riverine processes. The watershed assessment conducted for this project focused on watershed processes that form and maintain salmonid habitat. Landscape metrics describing the level of human alteration of natural ecosystem attributes were used as indicators of water quality, hydrology, channel geomorphology, instream habitat, and biotic integrity. Ecological (watershed) processes are related to and can be predicted based on specific aspects of spatial pattern. This study evaluated the hydrologic regime, sediment delivery regime, and riparian condition of the sub-watersheds that comprise the upper Grays River watershed relative to their natural range of conditions. Analyses relied primarily on available geographic information system (GIS) data describing landscape characteristics such as climate, vegetation type and maturity, geology and soils, topography, land use, and road density. In addition to watershed-scale landscape characteristics, the study area

  17. Grays River Watershed and Biological Assessment Final Report 2006.

    SciTech Connect

    May, Christopher W.; McGrath, Kathleen E.; Geist, David R.; Abbe, Timothy; Barton, Chase

    2008-02-04

    habitat conditions, and biological integrity. In addition, human land-use impacts are factored into the conceptual model because they can alter habitat quality and can disrupt natural habitat-forming processes. In this model (Figure S.1), aquatic habitat--both instream and riparian--is viewed as the link between watershed conditions and biologic responses. Based on this conceptual model, assessment of habitat loss and the resultant declines in salmonid populations can be conducted by relating current and historical (e.g., natural) habitat conditions to salmonid utilization, diversity, and abundance. In addition, assessing disrupted ecosystem functions and processes within the watershed can aid in identifying the causes of habitat change and the associated decline in biological integrity. In this same way, restoration, enhancement, and conservation projects can be identified and prioritized. A watershed assessment is primarily a landscape-scale evaluation of current watershed conditions and the associated hydrogeomorphic riverine processes. The watershed assessment conducted for this project focused on watershed processes that form and maintain salmonid habitat. Landscape metrics describing the level of human alteration of natural ecosystem attributes were used as indicators of water quality, hydrology, channel geomorphology, instream habitat, and biotic integrity. Ecological (watershed) processes are related to and can be predicted based on specific aspects of spatial pattern. This study evaluated the hydrologic regime, sediment delivery regime, and riparian condition of the sub-watersheds that comprise the upper Grays River watershed relative to their natural range of conditions. Analyses relied primarily on available geographic information system (GIS) data describing landscape characteristics such as climate, vegetation type and maturity, geology and soils, topography, land use, and road density. In addition to watershed-scale landscape characteristics, the study area

  18. Compiling and Linking | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Cooley Policies Documentation Feedback Please provide feedback to help guide us as we continue to build documentation for our new computing resource. [Feedback Form] Compiling and Linking Compilers and MPI GNU compilers are installed and are available in your default environment. Intel compilers (intel-cc and intel-fc) are installed in /soft/apps. The current version is 11.0; add the key "+intel-11.0" to your .softenvrc file to use them. Multiple MPI versions are available, controlled

  19. Linking Legacies F2002-00544

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Linking Legacies F2002-00544 Fizeau. This 11-kiloton atmospheric nuclear explosion, code-named "Fizeau," was one of 210 atmospheric nuclear tests conducted by the United States. Of the 1,054 nuclear tests explosions conducted by the U.S., 904 were detonated at the Nevada Test Site. All U.S. nuclear explosions since 1962 have been underground. Event Fizeau, Operation Plumbbob, Yucca Flat, Nevada Test Site, Neuada. 9:45 A.M., September 14, 1957. Barrels of transuranic waste sit on a

  20. Behavior of nanoceria in biologically-relevant environments

    SciTech Connect

    Kumar, Amit; Das, Soumen; Munusamy, Prabhakaran; Self, William; Baer, Donald R.; Sayle, Dean C.; Seal, Sudipta

    2014-09-08

    Cerium oxide nanoparticles (CNPs) have gained a considerable attention in biological research due to their anti-oxidant like behaviour and regenerative nature. The current literature on CNPs reports many successful attempts on harnessing the beneficial therapeutic properties in biology. However studies have also shown toxicity effect with some types of CNPs. This review discusses issues associated with the behaviours of CNPs in biological systems and identifies key knowledge gaps. We explore how salient physicochemical properties (size, surface chemistry, surface stabilizers) contribute to the potential positive and negative aspects of nanoceria in biological systems. Based on variations of results reported in the literature, important issues need to be addressed. Are we really studying the same particles with slight variations in size and physicochemical properties or do the particles being examined have fundamentally different behaviours? Are the variations observed in the result of differences in the initial properties of the particles or the results of downstream effects that emerge as the particles are prepared for specific studies and they interact with biological or other environmental moieties? How should particles be appropriately prepared for relevant environmental/toxicology/safety studies? It is useful to recognize that nanoparticles encompass some of the same complexities and variability associated with biological components

  1. External Links | U.S. DOE Office of Science (SC)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    External Links Budget Budget Home About Budget by Program GAO Audit Reports External Links Contact Information Budget U.S. Department of Energy SC-41/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3541 F: (301) 903-9524 More Information » External Links Print Text Size: A A A FeedbackShare Page Office of Management and Budget (OMB) External link OMB Budget Documents External link CFO Budget Office U.S. Senate External link U.S. House of Representatives External

  2. Chemically-functionalized microcantilevers for detection of chemical, biological and explosive material

    DOEpatents

    Pinnaduwage, Lal A [Knoxville, TN; Thundat, Thomas G [Knoxville, TN; Brown, Gilbert M [Knoxville, TN; Hawk, John Eric [Olive Branch, MS; Boiadjiev, Vassil I [Knoxville, TN

    2007-04-24

    A chemically functionalized cantilever system has a cantilever coated on one side thereof with a reagent or biological species which binds to an analyte. The system is of particular value when the analyte is a toxic chemical biological warfare agent or an explosive.

  3. Quantitative Visualization of ChIP-chip Data by Using Linked Views

    SciTech Connect

    Huang, Min-Yu; Weber, Gunther; Li, Xiao-Yong; Biggin, Mark; Hamann, Bernd

    2010-11-05

    Most analyses of ChIP-chip in vivo DNA binding have focused on qualitative descriptions of whether genomic regions are bound or not. There is increasing evidence, however, that factors bind in a highly overlapping manner to the same genomic regions and that it is quantitative differences in occupancy on these commonly bound regions that are the critical determinants of the different biological specificity of factors. As a result, it is critical to have a tool to facilitate the quantitative visualization of differences between transcription factors and the genomic regions they bind to understand each factor's unique roles in the network. We have developed a framework which combines several visualizations via brushing-and-linking to allow the user to interactively analyze and explore in vivo DNA binding data of multiple transcription factors. We describe these visualization types and also provide a discussion of biological examples in this paper.

  4. Air monitoring and detection of chemical and biological agents

    SciTech Connect

    Leonelli, J.; Althouse, M.L.

    1999-06-01

    This volume contains the proceedings of SPIE`s remote sensing symposium which was held November 2--3, 1998 in Boston, Massachusetts. Topics of discussion include the following: system simulations, atmospheric modeling, and performance prediction studies of chemical warfare remote sensing technologies; ultraviolet laser-induced fluorescence and aerosol detection methods for remote sensing of biological warfare agents; passive detection methods for remote detection of chemical warfare agents; and lidar-based system performance assessments, demonstrations, and new concepts for chemical warfare/biological warfare detection.

  5. Nippon Yusen KK NYK Link | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Link Jump to: navigation, search Name: Nippon Yusen KK (NYK Link) Place: Tokyo, Tokyo, Japan Zip: 100-0005 Sector: Solar Product: Logistics and shipping company moving to use...

  6. Widget:LinkedInCompany | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    allows you to add LinkedIn company widget to your wiki page. For example For nameGoogle: Widget:LinkedInCompany | nameGoogle Retrieved from "http:en.openei.orgw...

  7. Texas River Authority Website Links | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Legal Document- OtherOther: Texas River Authority Website LinksLegal Abstract The Texas Parks and Wildlife Department provides information on and links to each of the 23 river...

  8. Template:FilePreviewDirectLink | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    link to the actual asset instead of the file page about the asset. Parameters file - e.g. "LEDSGPslides.pdf" Usage Link to an OpenEI page (standard functionality)....

  9. Invited Review Article: Advanced light microscopy for biological space research

    SciTech Connect

    De Vos, Winnok H.; Beghuin, Didier; Schwarz, Christian J.; Jones, David B.; Loon, Jack J. W. A. van

    2014-10-15

    As commercial space flights have become feasible and long-term extraterrestrial missions are planned, it is imperative that the impact of space travel and the space environment on human physiology be thoroughly characterized. Scrutinizing the effects of potentially detrimental factors such as ionizing radiation and microgravity at the cellular and tissue level demands adequate visualization technology. Advanced light microscopy (ALM) is the leading tool for non-destructive structural and functional investigation of static as well as dynamic biological systems. In recent years, technological developments and advances in photochemistry and genetic engineering have boosted all aspects of resolution, readout and throughput, rendering ALM ideally suited for biological space research. While various microscopy-based studies have addressed cellular response to space-related environmental stressors, biological endpoints have typically been determined only after the mission, leaving an experimental gap that is prone to bias results. An on-board, real-time microscopical monitoring device can bridge this gap. Breadboards and even fully operational microscope setups have been conceived, but they need to be rendered more compact and versatile. Most importantly, they must allow addressing the impact of gravity, or the lack thereof, on physiologically relevant biological systems in space and in ground-based simulations. In order to delineate the essential functionalities for such a system, we have reviewed the pending questions in space science, the relevant biological model systems, and the state-of-the art in ALM. Based on a rigorous trade-off, in which we recognize the relevance of multi-cellular systems and the cellular microenvironment, we propose a compact, but flexible concept for space-related cell biological research that is based on light sheet microscopy.

  10. Workplace Charging Challenge Partner: LinkedIn | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    LinkedIn Workplace Charging Challenge Partner: LinkedIn Workplace Charging Challenge Partner: LinkedIn Joined the Challenge: August 2016 Headquarters: Sunnyvale, CA Charging Locations: Sunnyvale, CA; Carpinteria, CA Domestic Employees: 7,000 LinkedIn is committed to helping employees positively impact the planet and is pleased to offer free plug-in electric vehicle (PEV) charging at work so employees can reduce the emissions from their daily commute. Since its workplace charging program began in

  11. LAC Regional Platform Workshop Links | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Announcement Agenda Participant Package Accommodations Location & Transportation Insurance & Visas Participants Presentations Outcomes Report Links Contact Us One Page Event...

  12. Computerized training management system

    DOEpatents

    Rice, H.B.; McNair, R.C.; White, K.; Maugeri, T.

    1998-08-04

    A Computerized Training Management System (CTMS) is disclosed for providing a procedurally defined process that is employed to develop accreditable performance based training programs for job classifications that are sensitive to documented regulations and technical information. CTMS is a database that links information needed to maintain a five-phase approach to training-analysis, design, development, implementation, and evaluation independent of training program design. CTMS is designed using R-Base{trademark}, an-SQL compliant software platform. Information is logically entered and linked in CTMS. Each task is linked directly to a performance objective, which, in turn, is linked directly to a learning objective; then, each enabling objective is linked to its respective test items. In addition, tasks, performance objectives, enabling objectives, and test items are linked to their associated reference documents. CTMS keeps all information up to date since it automatically sorts, files and links all data; CTMS includes key word and reference document searches. 18 figs.

  13. Computerized training management system

    DOEpatents

    Rice, Harold B.; McNair, Robert C.; White, Kenneth; Maugeri, Terry

    1998-08-04

    A Computerized Training Management System (CTMS) for providing a procedurally defined process that is employed to develop accreditable performance based training programs for job classifications that are sensitive to documented regulations and technical information. CTMS is a database that links information needed to maintain a five-phase approach to training-analysis, design, development, implementation, and evaluation independent of training program design. CTMS is designed using R-Base.RTM., an-SQL compliant software platform. Information is logically entered and linked in CTMS. Each task is linked directly to a performance objective, which, in turn, is linked directly to a learning objective; then, each enabling objective is linked to its respective test items. In addition, tasks, performance objectives, enabling objectives, and test items are linked to their associated reference documents. CTMS keeps all information up to date since it automatically sorts, files and links all data; CTMS includes key word and reference document searches.

  14. NICS report links VOCs to respiratory problems

    SciTech Connect

    Kirschner, E.

    1992-04-22

    Children who live near the chemical plants of Kanawha Valley, WV, suffer more acute and chronic respiratory aliments than those farther away, says a Harvard University School of Public Health report. In the $1-million, five-year study commissioned by the National Institute for Chemical Studies (NICS:Charleston, WV) and funded by the Environmental Protection Agency, proximity to chemical plants that emit volatile organic compounds (VOCs) was linked to higher incidence of asthma, acute eye irritation, shortness of breath, and chronic cough. The researchers say they adjusted for most other factors, such as parental smoking and petroleum. {open_quotes}The research hypothesis was whether children in the valley had more symptoms,{close_quotes} says NICS president Paul Hill. {open_quotes}Yes, there is a difference.{close_quotes} The study showed that some ailments were up to 28% more prevalent in children in the valley than in other Kanawha County children.

  15. Link error from craype/2.5.0

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Link error from craype/2.5.0 Link error from craype/2.5.0 January 13, 2016 by Woo-Sun Yang If you build a code using a file called 'configure' with craype/2.5.0, Cray build-tools assumes that you want to use the 'native' link mode (e.g., gcc defaults to dynamic linking), by adding '-Wl,-rpath=/opt/intel/composer_xe_2015/compiler/lib/intel64 -lintlc'. This creates a link error: /usr/bin/ld: cannot find -lintlc A temporary work around is to swap the default craype (2.5.0) with an older or newer

  16. On Line Journals - Links - Cyclotron Institute

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Romanian Journal of Physics Nuclear Physics and Atomic Energy (National Academy of Sciences of Ukraine) Brazilian Journal of Physics Frontiers of Physics in China Few-Body Systems ...

  17. Hot Links to Cool Spots - Hanford Site

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    National Highway Traffic Safety Administration U.S. Fire Administration Federal Emergency Management Agency U.S. Department of Energy Wildland Fire Assessment System - USDA Forest...

  18. Chemical and biological warfare: Biology, chemistry, and toxicology. (Latest citations from the NTIS bibliographic database). Published Search

    SciTech Connect

    1996-10-01

    The bibliography contains citations concerning the physiological effects, physicochemical effects, and toxicology of chemical and biological warfare agents. Citations discuss toxic chemicals, chemical agent simulants, detoxification and decontamination, environmental toxicity, and land pollution. Detection techniques and warning systems are examined in a separate bibliography. (Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

  19. Chemical and biological warfare: Biology, chemistry, and toxicology. (Latest citations from the NTIS bibliographic database). Published Search

    SciTech Connect

    1995-10-01

    The bibliography contains citations concerning the physiological effects, physicochemical effects, and toxicology of chemical and biological warfare agents. Citations discuss toxic chemicals, chemical agent simulants, detoxification and decontamination, environmental toxicity, and land pollution. Detection techniques and warning systems are examined in a separate bibliography. (Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

  20. Chemical and biological warfare: Biology, chemistry, and toxicology. (Latest citations from the NTIS bibliographic database). Published Search

    SciTech Connect

    1995-03-01

    The bibliography contains citations concerning the physiological effects, physicochemical effects, and toxicology of chemical and biological warfare agents. Citations discuss toxic chemicals, chemical agent simulants, detoxification and decontamination, environmental toxicity, and land pollution. Detection techniques and warning systems are examined in a separate bibliography. (Contains a minimum of 229 citations and includes a subject term index and title list.)

  1. Chemical and biological warfare: Biology, chemistry, and toxicology. (Latest citations from the NTIS bibliographic database). Published Search

    SciTech Connect

    1997-11-01

    The bibliography contains citations concerning the physiological effects, physicochemical effects, and toxicology of chemical and biological warfare agents. Citations discuss toxic chemicals, chemical agent simulants, detoxification and decontamination, environmental toxicity, and land pollution. Detection techniques and warning systems are examined in a separate bibliography. (Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

  2. Algal Biology Toolbox Workshop Summary Report

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Biology Toolbox Workshop Summary Report San Diego, California May 2016 Summary report from the May 24-25, 2016, Algal Biology Toolbox Workshop in San Diego, California Workshop and ...

  3. Electronic Structure and Excited State Dynamics in Biological and Nanoscale

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Systems | MIT-Harvard Center for Excitonics Structure and Excited State Dynamics in Biological and Nanoscale Systems February 25, 2009 at 3pm/36-428 Gregory D. Scholes Department of Chemistry, University of Toronto scholes2 abstract: After photoexcitation, energy absorbed by a molecule can be transferred efficiently over a distance of up to several tens of Ångstrom to another molecule by the process of resonance energy transfer, RET (also commonly known as electronic energy transfer, EET).

  4. 2010 Diffraction Methods in Structural Biology

    SciTech Connect

    Dr. Ana Gonzalez

    2011-03-10

    Advances in basic methodologies have played a major role in the dramatic progress in macromolecular crystallography over the past decade, both in terms of overall productivity and in the increasing complexity of the systems being successfully tackled. The 2010 Gordon Research Conference on Diffraction Methods in Structural Biology will, as in the past, focus on the most recent developments in methodology, covering all aspects of the process from crystallization to model building and refinement, complemented by examples of structural highlights and complementary methods. Extensive discussion will be encouraged and it is hoped that all attendees will participate by giving oral or poster presentations, the latter using the excellent poster display area available at Bates College. The relatively small size and informal atmosphere of the meeting provides an excellent opportunity for all participants, especially younger scientists, to meet and exchange ideas with leading methods developers.

  5. Quantifying evolvability in small biological networks

    SciTech Connect

    Nemenman, Ilya; Mugler, Andrew; Ziv, Etay; Wiggins, Chris H

    2008-01-01

    The authors introduce a quantitative measure of the capacity of a small biological network to evolve. The measure is applied to a stochastic description of the experimental setup of Guet et al. (Science 2002, 296, pp. 1466), treating chemical inducers as functional inputs to biochemical networks and the expression of a reporter gene as the functional output. The authors take an information-theoretic approach, allowing the system to set parameters that optimise signal processing ability, thus enumerating each network's highest-fidelity functions. All networks studied are highly evolvable by the measure, meaning that change in function has little dependence on change in parameters. Moreover, each network's functions are connected by paths in the parameter space along which information is not significantly lowered, meaning a network may continuously change its functionality without completely losing it along the way. This property further underscores the evolvability of the networks.

  6. Recovery from chemical, biological, and radiological incidents :

    SciTech Connect

    Franco, David Oliver; Yang, Lynn I.; Hammer, Ann E.

    2012-06-01

    To restore regional lifeline services and economic activity as quickly as possible after a chemical, biological or radiological incident, emergency planners and managers will need to prioritize critical infrastructure across many sectors for restoration. In parallel, state and local governments will need to identify and implement measures to promote reoccupation and economy recovery in the region. This document provides guidance on predisaster planning for two of the National Disaster Recovery Framework Recovery Support Functions: Infrastructure Systems and Economic Recovery. It identifies key considerations for infrastructure restoration, outlines a process for prioritizing critical infrastructure for restoration, and identifies critical considerations for promoting regional economic recovery following a widearea disaster. Its goal is to equip members of the emergency preparedness community to systematically prioritize critical infrastructure for restoration, and to develop effective economic recovery plans in preparation for a widearea CBR disaster.

  7. Elemental and Chemically Specific X-ray Fluorescence Imaging of Biological

    Office of Scientific and Technical Information (OSTI)

    Systems (Journal Article) | DOE PAGES Published Article: Elemental and Chemically Specific X-ray Fluorescence Imaging of Biological Systems Title: Elemental and Chemically Specific X-ray Fluorescence Imaging of Biological Systems Authors: Pushie, M. Jake ; Pickering, Ingrid J. ; Korbas, Malgorzata ; Hackett, Mark J. ; George, Graham N. Publication Date: 2014-09-10 OSTI Identifier: 1179591 Type: Published Article Journal Name: Chemical Reviews Additional Journal Information: Journal Volume:

  8. Semiconductor Nanocrystals for Biological Imaging

    SciTech Connect

    Fu, Aihua; Gu, Weiwei; Larabell, Carolyn; Alivisatos, A. Paul

    2005-06-28

    Conventional organic fluorophores suffer from poor photo stability, narrow absorption spectra and broad emission feature. Semiconductor nanocrystals, on the other hand, are highly photo-stable with broad absorption spectra and narrow size-tunable emission spectra. Recent advances in the synthesis of these materials have resulted in bright, sensitive, extremely photo-stable and biocompatible semiconductor fluorophores. Commercial availability facilitates their application in a variety of unprecedented biological experiments, including multiplexed cellular imaging, long-term in vitro and in vivo labeling, deep tissue structure mapping and single particle investigation of dynamic cellular processes. Semiconductor nanocrystals are one of the first examples of nanotechnology enabling a new class of biomedical applications.

  9. ANAEROBIC BIOLOGICAL TREATMENT OF PRODUCED WATER

    SciTech Connect

    John R. Gallagher

    2001-07-31

    During the production of oil and gas, large amounts of water are brought to the surface and must be disposed of in an environmentally sensitive manner. This is an especially difficult problem in offshore production facilities where space is a major constraint. The chief regulatory criterion for produced water is oil and grease. Most facilities have little trouble meeting this criterion using conventional oil-water separation technologies. However, some operations have significant amounts of naphthenic acids in the water that behave as oil and grease but are not well removed by conventional technologies. Aerobic biological treatment of naphthenic acids in simulated-produced water has been demonstrated by others; however, the system was easily overloaded by the large amounts of low-molecular-weight organic acids often found in produced waters. The objective of this research was to determine the ability of an anaerobic biological system to treat these organic acids in a simulated produced water and to examine the potential for biodegradation of the naphthenic acids in the anaerobic environment. A small fixed-film anaerobic biological reactor was constructed and adapted to treat a simulated produced water. The bioreactor was tubular, with a low-density porous glass packing material. The inocula to the reactor was sediment from a produced-water holding pond from a municipal anaerobic digester and two salt-loving methanogenic bacteria. During start-up, the feed to the reactor contained glucose as well as typical produced-water components. When glucose was used, rapid gas production was observed. However, when glucose was eliminated and the major organic component was acetate, little gas was generated. Methane production from acetate may have been inhibited by the high salt concentrations, by sulfide, or because of the lack, despite seeding, of microbes capable of converting acetate to methane. Toluene, a minor component of the produced water (0.1 g/L) was removed in the

  10. Detection of biological molecules using chemical amplification and optical sensors

    DOEpatents

    Van Antwerp, William Peter; Mastrototaro, John Joseph

    2001-01-01

    Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal. Specifically, the analyte transducer immobilized in a polymeric matrix can be a boronic acid moiety.

  11. Microwaves and particle accelerators: a fundamental link

    SciTech Connect

    Chattopadhyay, Swapan

    2011-07-01

    John Cockcroft's splitting of the atom and Ernest Lawrence's invention of the cyclotron in the first half of the twentieth century ushered in the grand era of ever higher energy particle accelerators to probe deeper into matter. It also forged a link, bonding scientific discovery with technological innovation that continues today in the twenty first century. The development of radar and high power vacuum electronics, especially microwave power tubes like the magnetrons and the klystrons in the pre-second world war era, was instrumental in the rapid development of circular and linear charged particle accelerators in the second half of the twentieth century. We had harnessed the powerful microwave radio-frequency sources from few tens of MHz to up to 90 GHz spanning L-band to W-band frequencies. Simultaneously in the second half of the twentieth century, lasers began to offer very first opportunities of controlling charged particles at smaller resolutions on the scale of wavelengths of visible light. We also witnessed in this period the emergence of the photon and neutron sciences driven by accelerators built-by-design producing tailored and ultra-bright pulses of bright photons and neutrons to probe structure and function of matter from aggregate to individual molecular and atomic scales in unexplored territories in material and life sciences. As we enter the twenty first century, the race for ever higher energies, brightness and luminosity to probe atto-metric and atto-second domains of the ultra-small structures and ultra-fast processes continues. These developments depend crucially on yet further advancements in the production and control of high power and high frequency microwaves and light sources, often intricately coupled in their operation to the high energy beams themselves. We give a glimpse of the recent developments and innovations in the electromagnetic production and control of charged particle beams in the service of science and society. (author)

  12. Local intelligent electronic device (IED) rendering templates over limited bandwidth communication link to manage remote IED

    DOEpatents

    Bradetich, Ryan; Dearien, Jason A; Grussling, Barry Jakob; Remaley, Gavin

    2013-11-05

    The present disclosure provides systems and methods for remote device management. According to various embodiments, a local intelligent electronic device (IED) may be in communication with a remote IED via a limited bandwidth communication link, such as a serial link. The limited bandwidth communication link may not support traditional remote management interfaces. According to one embodiment, a local IED may present an operator with a management interface for a remote IED by rendering locally stored templates. The local IED may render the locally stored templates using sparse data obtained from the remote IED. According to various embodiments, the management interface may be a web client interface and/or an HTML interface. The bandwidth required to present a remote management interface may be significantly reduced by rendering locally stored templates rather than requesting an entire management interface from the remote IED. According to various embodiments, an IED may comprise an encryption transceiver.

  13. Compiling and Linking FAQ | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Overview of How to Compile and Link Example Program and Makefile for BG/Q How to Manage Threading bgclang Compiler Compiling and Linking FAQ Queueing & Running Jobs Data Transfer Debugging & Profiling Performance Tools & APIs Software & Libraries IBM References Cooley Policies Documentation Feedback Please provide feedback to help guide us as we continue to build documentation for our new computing resource. [Feedback Form] Compiling and Linking FAQ Contents Where do I find

  14. Exploring the Business Link Opportunity: Transmission & Clean Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Development in the West | Department of Energy Exploring the Business Link Opportunity: Transmission & Clean Energy Development in the West Exploring the Business Link Opportunity: Transmission & Clean Energy Development in the West February 7-8, 2012 Image of a speaker at the forum. Denver, Colorado Sheraton Denver Downtown Hotel The Tribal Leader Energy Forum, "Exploring the Business Link Opportunity: Transmission & Clean Energy Development in the West, " co-sponsored

  15. Employment at EERE Related Links | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    » Employment at EERE Related Links Employment at EERE Related Links If you are considering employment with the U.S. Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE), and even if you already are an EERE employee, you may find the following links helpful: Veterans' Employment Resources The American's Veteran site includes information to help you understand veterans' preference, how federal jobs are filled, and unique veteran appointing authorities designed to

  16. Advances in imaging secondary ion mass spectrometry for biological samples

    DOE PAGES [OSTI]

    Boxer, Steven G.; Kraft, Mary L.; Weber, Peter K.

    2008-12-16

    Imaging mass spectrometry combines the power of mass spectrometry to identify complex molecules based on mass with sample imaging. Recent advances in secondary ion mass spectrometry have improved sensitivity and spatial resolution, so that these methods have the potential to bridge between high-resolution structures obtained by X-ray crystallography and cyro-electron microscopy and ultrastructure visualized by conventional light microscopy. Following background information on the method and instrumentation, we address the key issue of sample preparation. Because mass spectrometry is performed in high vacuum, it is essential to preserve the lateral organization of the sample while removing bulk water, and this hasmore » been a major barrier for applications to biological systems. Furthermore, recent applications of imaging mass spectrometry to cell biology, microbial communities, and biosynthetic pathways are summarized briefly, and studies of biological membrane organization are described in greater depth.« less

  17. Method and apparatus for determining nutrient stimulation of biological processes

    DOEpatents

    Colwell, F.S.; Geesey, G.G.; Gillis, R.J.; Lehman, R.M.

    1999-07-13

    A method and apparatus are disclosed for determining the nutrients to stimulate microorganisms in a particular environment. A representative sample of microorganisms from a particular environment are contacted with multiple support means wherein each support means has intimately associated with the surface of the support means a different nutrient composition for microorganisms in the sample. The multiple support means is allowed to remain in contact with the microorganisms in the sample for a time period sufficient to measure difference in microorganism effects for the multiple support means. Microorganism effects for the multiple support means are then measured and compared. The invention is particularly adaptable to being conducted in situ. The additional steps of regulating nutrients added to the particular environment of microorganisms can enhance the desired results. Biological systems particularly suitable for this invention are bioremediation, biologically enhanced oil recovery, biological leaching of metals, and agricultural bioprocesses. 5 figs.

  18. Method and apparatus for determining nutrient stimulation of biological processes

    DOEpatents

    Colwell, Frederick S.; Geesey, Gill G.; Gillis, Richard J.; Lehman, R. Michael

    1999-01-01

    A method and apparatus for determining the nutrients to stimulate microorganisms in a particular environment. A representative sample of microorganisms from a particular environment are contacted with multiple support means wherein each support means has intimately associated with the surface of the support means a different nutrient composition for said microorganisms in said sample. The multiple support means is allowed to remain in contact with the microorganisms in the sample for a time period sufficient to measure difference in microorganism effects for the multiple support means. Microorganism effects for the multiple support means are then measured and compared. The invention is particularly adaptable to being conducted in situ. The additional steps of regulating nutrients added to the particular environment of microorganisms can enhance the desired results. Biological systems particularly suitable for this invention are bioremediation, biologically enhanced oil recovery, biological leaching of metals, and agricultural bioprocesses.

  19. Method and apparatus for determining nutrient stimulation of biological processes

    DOEpatents

    Colwell, Frederick S.; Geesey, Gill G.; Gillis, Richard J.; Lehman, R. Michael

    1997-01-01

    A method and apparatus for determining the nutrients to stimulate microorganisms in a particular environment. A representative sample of microorganisms from a particular environment are contacted with multiple support means wherein each support means has intimately associated with the surface of the support means a different nutrient composition for said microorganisms in said sample. The multiple support means is allowed to remain in contact with the microorganisms in the sample for a time period sufficient to measure differences in microorganism effects for the multiple support means. Microorganism effects for the multiple support means are then measured and compared. The invention is particularly adaptable to being conducted in situ. The additional steps of regulating nutrients added to the particular environment of microorganisms can enhance the desired results. Biological systems particularly suitable for this invention are bioremediation, biologically enhanced oil recovery, biological leaching of metals, and agricultural bioprocesses.

  20. Method and apparatus for determining nutrient stimulation of biological processes

    DOEpatents

    Colwell, F.S.; Geesey, G.G.; Gillis, R.J.; Lehman, R.M.

    1997-11-11

    A method and apparatus is described for determining the nutrients to stimulate microorganisms in a particular environment. A representative sample of microorganisms from a particular environment are contacted with multiple support means wherein each support means has intimately associated with the surface of the support means a different nutrient composition for said microorganisms in said sample. The multiple support means is allowed to remain in contact with the microorganisms in the sample for a time period sufficient to measure differences in microorganism effects for the multiple support means. Microorganism effects for the multiple support means are then measured and compared. The invention is particularly adaptable to being conducted in situ. The additional steps of regulating nutrients added to the particular environment of microorganisms can enhance the desired results. Biological systems particularly suitable for this invention are bioremediation, biologically enhanced oil recovery, biological leaching of metals, and agricultural bioprocesses. 5 figs.

  1. Data-intensive computing laying foundation for biological breakthroughs

    SciTech Connect

    Straatsma, TP

    2007-06-18

    Biological breakthroughs critical to solving society’s most challenging problems require new and innovative tools and a “different way” to analyze the enormous amounts of data being generated. This article for the Breakthroughs magazine focuses on the Data-Intensive Computing for Complex Biological Systems (Biopilot) project—a joint research effort between the Pacific Northwest National Laboratory (PNNL) and Oak Ridge National Laboratory funded by the U.S. Department of Energy’s Office of Advanced Scientific Computing Research. The two national laboratories, both of whom are world leaders in computing and computational sciences, are teaming to support areas of biological research in urgent need of data-intensive computing capabilities.

  2. Rapid classification of biological components

    DOEpatents

    Thompson, Vicki S.; Barrett, Karen B.; Key, Diane E.

    2013-10-15

    A method is disclosed for analyzing a biological sample by antibody profiling for identifying forensic samples or for detecting the presence of an analyte. In an illustrative embodiment of the invention, the analyte is a drug, such as marijuana, cocaine (crystalline tropane alkaloid), methamphetamine, methyltestosterone, or mesterolone. The method involves attaching antigens to a surface of a solid support in a preselected pattern to form an array wherein the locations of the antigens are known; contacting the array with the biological sample such that a portion of antibodies in the sample reacts with and binds to antigens in the array, thereby forming immune complexes; washing away antibodies that do not form immune complexes; and detecting the immune complexes, thereby forming an antibody profile. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source. Further, an assay, such as a test for illegal drug use, can be coupled to a test for identity such that the results of the assay can be positively correlated to a subject's identity.

  3. Rapid classification of biological components

    DOEpatents

    Thompson, Vicki S.; Barrett, Karen B.; Key, Diane E.

    2010-03-23

    A method is disclosed for analyzing a biological sample by antibody profiling for identifying forensic samples or for detecting the presence of an analyte. In an illustrative embodiment of the invention, the analyte is a drug, such as marijuana, cocaine (crystalline tropane alkaloid), methamphetamine, methyltestosterone, or mesterolone. The method involves attaching antigens to a surface of a solid support in a preselected pattern to form an array wherein the locations of the antigens are known; contacting the array with the biological sample such that a portion of antibodies in the sample reacts with and binds to antigens in the array, thereby forming immune complexes; washing away antibodies that do not form immune complexes; and detecting the immune complexes, thereby forming an antibody profile. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source. Further, an assay, such as a test for illegal drug use, can be coupled to a test for identity such that the results of the assay can be positively correlated to a subject's identity.

  4. Rapid classification of biological components

    DOEpatents

    Thompson, Vicki S.; Barrett, Karen B.; Key, Diane E.

    2006-01-24

    A method is disclosed for analyzing a biological sample by antibody profiling for identifying forensic samples or for detecting the presence of an analyte. In an illustrative embodiment of the invention, the analyte is a drug, such as marijuana, cocaine, methamphetamine, methyltestosterone, or mesterolone. The method involves attaching antigens to the surface of a solid support in a preselected pattern to form an array wherein the locations of the antigens are known; contacting the array with the biological sample such that a portion of antibodies in the sample reacts with and binds to antigens in the array, thereby forming immune complexes; washing away antibodies that do form immune complexes; and detecting the immune complexes, thereby forming an antibody profile. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source. Further, an assay, such as a test for illegal drug use, can be coupled to a test for identity such that the results of the assay can be positively correlated to the subject's identity.

  5. Rapid classification of biological components

    SciTech Connect

    Thompson, Vicki S.; Barrett, Karen B.; Key, Diane E.

    2010-03-23

    A method is disclosed for analyzing a biological sample by antibody profiling for identifying forensic samples or for detecting the presence of an analyte. In an illustrative embodiment of the invention, the analyte is a drug, such as marijuana, Cocaine (crystalline tropane alkaloid), methamphetamine, methyltestosterone, or mesterolone. The method involves attaching antigens of the surface of a solid support in a preselected pattern to form an array wherein the locations of the antigens are known; contacting the array with the biological sample such that a portion of antibodies in the sample reacts with and binds to antigens in the array, thereby forming immune complexes; washing away antibodies that do not form immune complexes; and detecting the immune complexes, thereby forming an antibody profile. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source. Further, an assay, such as a test for illegal drug use, can be coupled to a test for identity such that the results of the assay can be positively correlated to a subject's identity.

  6. Exploring Competing Kinetic Processes in Quantum Dots Linked...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Competing Kinetic Processes in Quantum Dots Linked to Electrode Surfaces March 14, 2012 at 2:30pm4-349 Mark Hybertsen Brookhaven National Laboratory, Columbia University ...

  7. Radiation Effects Research Foundation Links Past and Future ...

    Energy Saver

    Radiation Effects Research Foundation Links Past and Future August 2009 This document provides historical information about the Radiation Effects Research Foundation and its core ...

  8. WAFER TEST CAVITY -Linking Surface Microstructure to RF Performance...

    Office of Scientific and Technical Information (OSTI)

    WAFER TEST CAVITY -Linking Surface Microstructure to RF Performance: a 'Short--Sample Test Facility' for characterizing superconducting materials for SRF cavities. Citation Details ...

  9. Other EEOICP Links and Previous Federal Register Notices | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Health (NIOSH), Office of Compensation Analysis and Support (OCAS) NIOSH performs dose ... Linking Legacies - the story of the creation and development of the U.S. nuclear ...

  10. California/Transmission/Agency Links | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    State Agency Links California Department of Fish and Wildlife California Office of Historic Preservation California Department of Transportation California Department of...

  11. Idaho/Transmission/Agency Links | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    State Agency Links Idaho Department of Fish and Game Idaho State Historical Society Idaho Department of Environmental Quality Idaho Transportation Department Idaho Department of...

  12. Final Progress Report for Linking Ion Solvation and Lithium Battery

    Office of Scientific and Technical Information (OSTI)

    for Linking Ion Solvation and Lithium Battery Electrolyte Properties Henderson, Wesley 25 ENERGY STORAGE battery, electrolyte, solvation, ionic association battery, electrolyte,...

  13. LEDS Collaboration in Action Workshop Links | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    LEDS Collaboration in Action Workshop Links Jump to: navigation, search Low Emission Development Strategies Global Partnership Advancing climate-resilient, low-emission development...

  14. Modification of Lignin by Protein Cross-linking to Facilitate...

    Office of Scientific and Technical Information (OSTI)

    Production of Biofuels From Poplar Citation Details In-Document Search Title: Modification of Lignin by Protein Cross-linking to Facilitate Production of Biofuels From Poplar The ...

  15. An Allosteric Interaction Links USP7 to Deubiquitination and...

    Office of Scientific and Technical Information (OSTI)

    Title: An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1 Authors: Zhang, Zhi-Min ; Rothbart, Scott B. ; Allison, David F. ; Cai, Qian ; ...

  16. AEC Experiment Establishes Computer Link Between California and...

    Office of Scientific and Technical Information (OSTI)

    in Paris could search a computer in California and display the resulting bibliographic ... AEC EXPERIMENT ESTABLISHES COMPUTER LINK BETWEEN CALIFORNIA AND PARIS The feasibility of a ...

  17. EIS-0503: New England Clean Power Link, Vermont | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Power Company substation in Cavendish, VT. EIS-0503: New England Clean Power Link, Vermont Public Comment Opportunities No public comment opportunities available at this time. ...

  18. Linking Network Microstructure to Macroscopic Properties of Siloxane...

    Office of Scientific and Technical Information (OSTI)

    Title: Linking Network Microstructure to Macroscopic Properties of Siloxane Elastomers Using Combined Nuclear Magnetic Resonance and Mesoscale Computational Modeling Authors: Mayer...

  19. Adaptation of the control equipment to permit 3-terminal operation of the HVDC link between Sardinia, Corsica and mainland Italy

    SciTech Connect

    Mazzoldi, F.; Taisne, J.P.; Martin, C.J.B.; Rowe, B.A.

    1989-04-01

    After more than 20 years service as a conventional 2-terminal HVdc link, the Sardinia-Mainland Italy hvdc link (200MW, 200kV) is now operating as a three-terminal system. The original control equipment has been modified to allow the introduction of a tapping station on the line for 3-terminal operation. The adaptations to the control equipment, including the means to ensure that the convertors are operated within their capabilities, are explained.

  20. Interfacing nanostructures to biological cells

    DOEpatents

    Chen, Xing; Bertozzi, Carolyn R.; Zettl, Alexander K.

    2012-09-04

    Disclosed herein are methods and materials by which nanostructures such as carbon nanotubes, nanorods, etc. are bound to lectins and/or polysaccharides and prepared for administration to cells. Also disclosed are complexes comprising glycosylated nanostructures, which bind selectively to cells expressing glycosylated surface molecules recognized by the lectin. Exemplified is a complex comprising a carbon nanotube functionalized with a lipid-like alkane, linked to a polymer bearing repeated .alpha.-N-acetylgalactosamine sugar groups. This complex is shown to selectively adhere to the surface of living cells, without toxicity. In the exemplified embodiment, adherence is mediated by a multivalent lectin, which binds both to the cells and the .alpha.-N-acetylgalactosamine groups on the nanostructure.

  1. Characterization of intact N- and O-linked glycopeptides using higher energy collisional dissociation

    SciTech Connect

    Cao, Li; Tolic, Nikola; Qu, Yi; Meng, Da; Zhao, Rui; Zhang, Qibin; Moore, Ronald J.; Zink, Erika M.; Lipton, Mary S.; Pasa-Tolic, Ljiljana; Wu, Si

    2014-01-15

    Simultaneous elucidation of the glycan structure and the glycosylation site are needed to reveal the biological function of protein glycosylation. In this study, we employed a recent type of fragmentation termed higher energy collisional dissociation (HCD) to examine fragmentation patterns of intact glycopeptides generated from a mixture of standard glycosylated proteins. The normalized collisional energy (NCE) value for HCD was varied from 30% to 60% to evaluate the optimal conditions for the fragmentation of peptide backbones and glycoconjugates. Our results indicated that HCD with lower NCE valuespreferentially fragmented the sugar chains attached to the peptides to generate a ladder of neutral loss of monosaccharides, thus enabling the putative glycan structure characterization. Also, detection of the oxonium ions enabled unambiguous differentiation of glycopeptides from non-glycopeptides. On the contrary, HCD with higher NCE values preferentially fragmented the peptide backbone and thus provided information needed for confident peptide identification. We evaluated the HCD approach with alternating NCE parameters for confident characterization of intact N-linked and O-linked glycopeptides in a single liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. In addition, we applied a novel data analysis pipeline, so-called GlycoFinder, to form a basis for automated data analysis. Overall, 38 unique intact glycopeptides corresponding to eight glycosylation sites (including six N-linked and two O-linked sites) were confidently identified from a standard protein mixture. This approach provided concurrent characterization of both, the peptide and the glycan, thus enabling comprehensive structural characterization of glycoproteins in a single LC-MS/MS analysis.

  2. Application of GTO voltage source inverter in a hybrid HVDC link

    SciTech Connect

    Zhao, Z.; Iravani, M.R. . Dept. of Electrical Engineering)

    1994-01-01

    This paper investigates the application of a GTO voltage source inverter in a two-terminal HVdc link, which is fed at the sending end by a line-commutated rectifier. This type of HVdc link may be applied when power transfer is predominantly unidirectional, especially to a weak ac system. The investigations are based on analytical studies and digital time-domain simulations with the Electro-Magnetic Transient program for DC systems (EMTDC). Control method and protection requirements are studied, together with dynamic behavior of the system following disturbances, e.g. dc fault, ac fault, start-up etc. The studies are aimed at exhibiting the technical feasibility of the proposed HVdc scheme. Need for further studies is pointed out when necessary.

  3. Biological and Environmental Research (BER) Homepage | U.S. DOE...

    Office of Science (SC)

    EXPLORING the frontiers of genome-enabled biology. Understanding Complex Biological and ... and inquiry in atmospheric chemistry and physics, ecology, biology, and biogeochemistry. ...

  4. Breaking the Biological Barriers to Cellulosic Ethanol, June...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Breaking the Biological Barriers to Cellulosic Ethanol, June 2006 Breaking the Biological Barriers to Cellulosic Ethanol, June 2006 Breaking the Biological Barriers to Cellulosic ...

  5. OTEC environmental biological oceanographic program

    SciTech Connect

    Hartwig, E.O.

    1981-07-01

    One of the major goals of the OTEC biological field measurement program is to assess the effect of OTEC operations on the environment. Prior understanding of the natural variability of the tropical oceanic plankton community is the most important method for determining changes due to operation of an OTEC plant. The spatial and temporal patterns of the plankton community in terms of absolute number, biomass and species composition have been investigated at potential OTEC sites. Considerable data exist which document the changes with depth of all three measurements. Diel fluctuations in number and species composition have been studied at one site. While horizontal and seasonal patterns of variability likely exist at all sites, they are subtle and remain somewhat unclear. Attempts are now being made to determine the overall trophic structure of the plankton community at these sites using these data, gut content analysis, and information already in the literature.

  6. Temperature dependence of creep compliance of highly cross-linked epoxy: A molecular simulation study

    SciTech Connect

    Khabaz, Fardin Khare, Ketan S. Khare, Rajesh

    2014-05-15

    We have used molecular dynamics (MD) simulations to study the effect of temperature on the creep compliance of neat cross-linked epoxy. Experimental studies of mechanical behavior of cross-linked epoxy in literature commonly report creep compliance values, whereas molecular simulations of these systems have primarily focused on the Youngs modulus. In this work, in order to obtain a more direct comparison between experiments and simulations, atomistically detailed models of the cross-linked epoxy are used to study their creep compliance as a function of temperature using MD simulations. The creep tests are performed by applying a constant tensile stress and monitoring the resulting strain in the system. Our results show that simulated values of creep compliance increase with an increase in both time and temperature. We believe that such calculations of the creep compliance, along with the use of time temperature superposition, hold great promise in connecting the molecular insight obtained from molecular simulation at small length- and time-scales with the experimental behavior of such materials. To the best of our knowledge, this work is the first reported effort that investigates the creep compliance behavior of cross-linked epoxy using MD simulations.

  7. Enzyme linked immunoassay with stabilized polymer saccharide enzyme conjugates

    DOEpatents

    Callstrom, Matthew R. (Columbus, OH); Bednarski, Mark D. (Berkeley, CA); Gruber, Patrick R. (St. Paul, MN)

    1997-01-01

    An improvement in enzyme linked immunoassays is disclosed wherein the enzyme is in the form of a water soluble polymer saccharide conjugate which is stable in hostile environments. The conjugate comprises the enzyme which is linked to the polymer at multiple points through saccharide linker groups.

  8. Linking Network Microstructure to Macroscopic Properties of Siloxane

    Office of Scientific and Technical Information (OSTI)

    Elastomers Using Combined Nuclear Magnetic Resonance and Mesoscale Computational Modeling (Journal Article) | SciTech Connect Journal Article: Linking Network Microstructure to Macroscopic Properties of Siloxane Elastomers Using Combined Nuclear Magnetic Resonance and Mesoscale Computational Modeling Citation Details In-Document Search Title: Linking Network Microstructure to Macroscopic Properties of Siloxane Elastomers Using Combined Nuclear Magnetic Resonance and Mesoscale Computational

  9. Enzyme linked immunoassay with stabilized polymer saccharide enzyme conjugates

    DOEpatents

    Callstrom, M.R.; Bednarski, M.D.; Gruber, P.R.

    1997-11-25

    An improvement in enzyme linked immunoassays is disclosed wherein the enzyme is in the form of a water soluble polymer saccharide conjugate which is stable in hostile environments. The conjugate comprises the enzyme which is linked to the polymer at multiple points through saccharide linker groups. 19 figs.

  10. Key_E-Link_metadata.png | OSTI, US Dept of Energy Office of Scientific and

    Office of Scientific and Technical Information (OSTI)

    Technical Information Key_E-Link_metadata.png

  11. 2012 PLANT MOLECULAR BIOLOGY GORDON RESEARCH CONFERENCE, JULY 15-20, 2012

    SciTech Connect

    Sussman, Michael

    2013-07-20

    The 2012 Gordon Conference on Plant Molecular Biology will present cutting-edge research on molecular aspects of plant growth and development, with particular emphasis on recent discoveries in molecular mechanisms involved with plant signaling systems. The Conference will feature a wide range of topics in plant molecular biology including hormone receptors and early events in hormone signaling, plant perception of and response to plant pathogen and symbionts, as well as technological and biological aspects of epigenomics particularly as it relates to signaling systems that regulate plant growth and development. Genomic approaches to plant signaling will be emphasized, including genomic profiling technologies for quantifying various biological subsystems, such as the epigenome, transcriptome, phosphorylome, and metabolome. The meeting will include an important session devoted to answering the question, "What are the biological and technological limits of plant breeding/genetics, and how can they be solved"?

  12. 2012 CELLULAR & MOLECULAR FUNGAL BIOLOGY GORDON RESEARCH CONFERENCE, JUNE 17 - 22, 2012

    SciTech Connect

    Judith Berman

    2012-06-22

    The Gordon Research Conference on CELLULAR & MOLECULAR FUNGAL BIOLOGY was held at Holderness School, Holderness New Hampshire, June 17 - 22, 2012. The 2012 Gordon Conference on Cellular and Molecular Fungal Biology (CMFB) will present the latest, cutting-edge research on the exciting and growing field of molecular and cellular aspects of fungal biology. Topics will range from yeast to filamentous fungi, from model systems to economically important organisms, and from saprophytes and commensals to pathogens of plants and animals. The CMFB conference will feature a wide range of topics including systems biology, cell biology and morphogenesis, organismal interactions, genome organisation and regulation, pathogenesis, energy metabolism, biomass production and population genomics. The Conference was well-attended with 136 participants. Gordon Research Conferences does not permit publication of meeting proceedings.

  13. Developing Biological Specifications for Fish Friendly Turbines |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Developing Biological Specifications for Fish Friendly Turbines Developing Biological Specifications for Fish Friendly Turbines This factsheet explains studies conducted in a highly reproducible manner to examine the biological effects to fish exposed to a shear environment in the laboratory. bio_specific_fish_friendly_turbines.pdf (59.94 KB) More Documents & Publications Environmental Effects of Hydrokinetic Turbines on Fish: Desktop and Laboratory Flume Studies

  14. Hazmat Cam Wireless Video System

    SciTech Connect

    Kevin L. Young

    2006-02-01

    This paper describes the Hazmat Cam Wireless Video System and its application to emergency response involving chemical, biological or radiological contamination. The Idaho National Laboratory designed the Hazmat Cam Wireless Video System to assist the National Guard Weapons of Mass Destruction - Civil Support Teams during their mission of emergency response to incidents involving weapons of mass destruction. The lightweight, handheld camera transmits encrypted, real-time video from inside a contaminated area, or hot-zone, to a command post located a safe distance away. The system includes a small wireless video camera, a true-diversity receiver, viewing console, and an optional extension link that allows the command post to be placed up to five miles from danger. It can be fully deployed by one person in a standalone configuration in less than 10 minutes. The complete system is battery powered. Each rechargeable camera battery powers the camera for 3 hours with the receiver and video monitor battery lasting 22 hours on a single charge. The camera transmits encrypted, low frequency analog video signals to a true-diversity receiver with three antennas. This unique combination of encryption and transmission technologies delivers encrypted, interference-free images to the command post under conditions where other wireless systems fail. The lightweight camera is completely waterproof for quick and easy decontamination after use. The Hazmat Cam Wireless Video System is currently being used by several National Guard Teams, the US Army, and by fire fighters. The system has been proven to greatly enhance situational awareness during the crucial, initial phase of a hazardous response allowing commanders to make better, faster, safer decisions.

  15. Vehicle brake testing system

    DOEpatents

    Stevens, Samuel S.; Hodgson, Jeffrey W.

    2002-11-19

    This invention relates to a force measuring system capable of measuring forces associated with vehicle braking and of evaluating braking performance. The disclosure concerns an invention which comprises a first row of linearly aligned plates, a force bearing surface extending beneath and beside the plates, vertically oriented links and horizontally oriented links connecting each plate to a force bearing surface, a force measuring device in each link, a transducer coupled to each force measuring device, and a computing device coupled to receive an output signal from the transducer indicative of measured force in each force measuring device. The present invention may be used for testing vehicle brake systems.

  16. A brief history of the Biology Complex

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Complex Most of the "Biology" buildings were constructed in early 1945 and were built as expansion capability for the uranium preparation operations being conducted across the...

  17. Autofermentative Biological Hydrogen Production by Cyanobacteria

    Office of Energy Efficiency and Renewable Energy (EERE)

    Presentation by Charles Dismukes, Rutgers University, at the Biological Hydrogen Production Workshop held September 24-25, 2013, at the National Renewable Energy Laboratory in Golden, Colorado.

  18. Molecular biology of signal transduction in plants

    SciTech Connect

    Not Available

    1991-01-01

    This volume contains abstracts of oral presentations and poster sessions of the 1991 Cold Springs Harbor Meeting entitled Molecular Biology of Signal Transduction in Plants.

  19. Developing Biological Specifications for Fish Friendly Turbines

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Biological Specifications for Fish Friendly Turbines The U.S. Department of Energy's ... which environmen- tal attributes, such as entrainment survival for fish, are emphasized. ...

  20. Portable pathogen detection system

    DOEpatents

    Colston, Billy W.; Everett, Matthew; Milanovich, Fred P.; Brown, Steve B.; Vendateswaran, Kodumudi; Simon, Jonathan N.

    2005-06-14

    A portable pathogen detection system that accomplishes on-site multiplex detection of targets in biological samples. The system includes: microbead specific reagents, incubation/mixing chambers, a disposable microbead capture substrate, and an optical measurement and decoding arrangement. The basis of this system is a highly flexible Liquid Array that utilizes optically encoded microbeads as the templates for biological assays. Target biological samples are optically labeled and captured on the microbeads, which are in turn captured on an ordered array or disordered array disposable capture substrate and then optically read.

  1. Biological responses to engineered nanomaterials: Needs for the next decade

    DOE PAGES [OSTI]

    Murphy, Catherine J.; Vartanian, Ariane M.; Geiger, Franz M.; Hamers, Robert J.; Pedersen, Joel A.; Cui, Qiang; Haynes, Christy L.; Carlson, Erin E.; Hernandez, Rigoberto; Klaper, Rebecca D.; et al

    2015-06-09

    In this study, the interaction of nanomaterials with biomolecules, cells, and organisms is an enormously vital area of current research, with applications in nanoenabled diagnostics, imaging agents, therapeutics, and contaminant removal technologies. Yet the potential for adverse biological and environmental impacts of nanomaterial exposure is considerable and needs to be addressed to ensure sustainable development of nanomaterials. In this Outlook four research needs for the next decade are outlined: (i) measurement of the chemical nature of nanomaterials in dynamic, complex aqueous environments; (ii) real-time measurements of nanomaterial-biological interactions with chemical specificity; (iii) delineation of molecular modes of action for nanomaterialmore » effects on living systems as functions of nanomaterial properties; and (iv) an integrated systems approach that includes computation and simulation across orders of magnitude in time and space.« less

  2. Biological responses to engineered nanomaterials: Needs for the next decade

    SciTech Connect

    Murphy, Catherine J.; Vartanian, Ariane M.; Geiger, Franz M.; Hamers, Robert J.; Pedersen, Joel A.; Cui, Qiang; Haynes, Christy L.; Carlson, Erin E.; Hernandez, Rigoberto; Klaper, Rebecca D.; Orr, Galya; Rosenzweig, Ze'ev

    2015-06-09

    In this study, the interaction of nanomaterials with biomolecules, cells, and organisms is an enormously vital area of current research, with applications in nanoenabled diagnostics, imaging agents, therapeutics, and contaminant removal technologies. Yet the potential for adverse biological and environmental impacts of nanomaterial exposure is considerable and needs to be addressed to ensure sustainable development of nanomaterials. In this Outlook four research needs for the next decade are outlined: (i) measurement of the chemical nature of nanomaterials in dynamic, complex aqueous environments; (ii) real-time measurements of nanomaterial-biological interactions with chemical specificity; (iii) delineation of molecular modes of action for nanomaterial effects on living systems as functions of nanomaterial properties; and (iv) an integrated systems approach that includes computation and simulation across orders of magnitude in time and space.

  3. 2013 METALS IN BIOLOGY GORDON RESEARCH CONFERENCE, JANUARY 20-25, 2013

    SciTech Connect

    Rosenzweig, Amy

    2013-01-25

    Typical topics for lectures and posters include: biochemical and biophysical characterization of new metal containing proteins, enzymes, nucleic acids, factors, and chelators from all forms of life; synthesis, detailed characterization, and reaction chemistry of biomimetic compounds; novel crystal and solution structures of biological molecules and synthetic metal-chelates; discussions of the roles that metals play in medicine, maintenance of the environment, and biogeochemical processes; metal homeostasis; application of theory and computations to the structure and mechanism of metal-containing biological systems; and novel applications of spectroscopy to metals in biological systems.

  4. Interdisciplinary Dialogue for Education, Collaboration, and Innovation: Intelligent Biology and Medicine In and Beyond 2013

    SciTech Connect

    Zhang, Bing; Huang, Yufei; McDermott, Jason E.; Posey, Rebecca H.; Xu, Hua; Zhao, Zhongming

    2013-12-09

    The 2013 International Conference on Intelligent Biology and Medicine (ICIBM 2013) was held on August 11-13, 2013 in Nashville, Tennessee, USA. The conference included six scientific sessions, two tutorial sessions, one workshop, two poster sessions, and four keynote presentations that covered cutting-edge research topics in bioinformatics, systems biology, computational medicine, and intelligent computing. Here, we present a summary of the conference and an editorial report of the supplements to BMC Genomics and BMC Systems Biology that include 19 research papers selected from ICIBM 2013.

  5. Synthetic Biology: Engineering, Evolution and Design (SEED) Conference 2014

    SciTech Connect

    Voigt, Christopher

    2014-07-01

    SEED2014 focused on advances in the science and technology emerging from the field of synthetic biology. We broadly define this as technologies that accelerate the process of genetic engineering. It highlighted new tool development, as well as the application of these tools to diverse problems in biotechnology, including therapeutics, industrial chemicals and fuels, natural products, and agriculture. Systems spanned from in vitro experiments and viruses, through diverse bacteria, to eukaryotes (yeast, mammalian cells, plants).

  6. Expedited Synthesis of Fluorine-18 Labeled Phenols. A Missing Link in PET Radiochemistry

    SciTech Connect

    Katzenellenbogen, John A.; Zhou, Dong

    2015-03-26

    Fluorine-18 (F-18) is arguably the most valuable radionuclide for positron emission tomographic (PET) imaging. However, while there are many methods for labeling small molecules with F-18 at aliphatic positions and on electron-deficient aromatic rings, there are essentially no reliable and practical methods to label electron-rich aromatic rings such as phenols, with F-18 at high specific activity. This is disappointing because fluorine-labeled phenols are found in many drugs; there are also many interesting plant metabolites and hormones that contain either phenols or other electron-rich aromatic systems such as indoles whose metabolism, transport, and distribution would be interesting to study if they could readily be labeled with F-18. Most approaches to label phenols with F-18 involve the labeling of electron-poor precursor arenes by nucleophilic aromatic substitution, followed by subsequent conversion to phenols by oxidation or other multi-step sequences that are often inefficient and time consuming. Thus, the lack of good methods for labeling phenols and other electron-rich aromatics with F-18 at high specific activity represents a significant methodological gap in F-18 radiochemistry that can be considered a “Missing Link in PET Radiochemistry”. The objective of this research project was to develop and optimize a series of unusual synthetic transformations that will enable phenols (and other electron-rich aromatic systems) to be labeled with F-18 at high specific activity, rapidly, reliably, and conveniently, thereby bridging this gap. Through the studies conducted with support of this project, we have substantially advanced synthetic methodology for the preparation of fluorophenols. Our progress is presented in detail in the sections below, and much has been published or presented publication; other components are being prepared for publication. In essence, we have developed a completely new method to prepare o-fluorophenols from non-aromatic precursors

  7. Federal Emergency Management Information System (FEMIS) system administration guide. Version 1.4

    SciTech Connect

    Arp, J.A.; Burnett, R.A.; Downing, T.R.

    1997-11-21

    The Federal Emergency Management Information System (FEMIS) is an emergency management planning and analysis tool that was developed by the Pacific Northwest National Laboratory (PNNL) under the direction of the US Army Chemical Biological Defense Command. The FEMIS System Administration Guide defines FEMIS hardware and software requirements and gives instructions for installing the FEMIS software package. This document also contains information on the following: software installation for the FEMIS data servers, communication server, mail server, and the emergency management workstations; distribution media loading and FEMIS installation validation and troubleshooting; and system management of FEMIS users, login privileges, and usage. The system administration utilities (tools), available in the FEMIS client software, are described for user accounts and site profile. This document also describes the installation and use of system and database administration utilities that will assist in keeping the FEMIS system running in an operational environment. The FEMIS system is designed for a single Chemical Stockpile Emergency Preparedness Program (CSEPP) site that has multiple Emergency Operations Centers (EOCs). Each EOC has personal computers (PCs) that emergency planners and operations personnel use to do their jobs. These PCs are connected via a local area network (LAN) to servers that provide EOC-wide services. Each EOC is interconnected to other EOCs via telecommunications links.

  8. Hybrid Multidimensional Relational and Link Analytical Knowledge Discovery for Law Enforcement

    SciTech Connect

    Joslyn, Cliff A.; Gillen, David S.; Burke, John S.; Critchlow, Terence J.; Damante, Matt; Fernandes, Robert

    2008-08-01

    The challenges facing the Department of Homeland Security (DHS) require not only multi-dimensional, but also multi-scale data analysis. In particular, the ability to seamlessly move from summary information, such as trends, into detailed analysis of individual entities, while critical for law enforcement, typically requires manually transferring information among multiple tools. Such time-consuming and error prone processes significantly hamper the analysts' ability to quickly explore data and identify threats. As part of a DHS Science and Technology effort, we have been developing and deploying for Immigration and Customs Enforcement the CubeLink system integrating information between relational data cubes and link analytical semantic graphs. In this paper we describe CubeLink in terms of the underlying components, their integration, and the formal mapping from multidimensional data analysis into link analysis. In so doing, we provide a formal basis for one particular form of automatic schema-ontology mapping from OLAP data cubes to semantic graphs databases, and point the way towards future ``intelligent'' OLAP data cubes equipped with meta-data about their dimensional typing.

  9. Ninth International Workshop on Plant Membrane Biology

    SciTech Connect

    Not Available

    1993-12-31

    This report is a compilation of abstracts from papers which were discussed at a workshop on plant membrane biology. Topics include: plasma membrane ATP-ases; plant-environment interactions, membrane receptors; signal transduction; ion channel physiology; biophysics and molecular biology; vaculor H+ pumps; sugar carriers; membrane transport; and cellular structure and function.

  10. Reference Links | U.S. DOE Office of Science (SC)

    Office of Science (SC)

    IL 60439 P: (630) 252-2110 Kenneth Tarcza U.S. Department of Energy 200 Administration Road Oak Ridge, TN 37830 P: (865) 576-4444 Privacy Act Reference Links Print Text Size: A A ...

  11. Mach-Zehnder Fiber-Optic Links for ICF Diagnostics

    SciTech Connect

    Miller, E. K., Hermann, H. W.

    2012-11-01

    This article describes the operation and evolution of Mach-Zehnder links for single-point detectors in inertial confinement fusion experimental facilities, based on the Gamma Reaction History (GRH) diagnostic at the National Ignition Facility.

  12. IDENTIFYING GENES CONTROLLING FERULATE CROSS-LINKING FORMATION...

    Office of Scientific and Technical Information (OSTI)

    of cross-linking and in turn impact biomass utility for forage and biofuel production. ... gene in the cell wall of maize or other biofuel crops, aiming to improve their ...

  13. Property:Incentive/Auth5Link | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    "IncentiveAuth5Link" Showing 25 pages using this property. (previous 25) (next 25) A Alternative Energy Portfolio Standard (Pennsylvania) + http:www.puc.state.pa.usPcDocs...

  14. Reference Linking at the DOE Office of Scientific and Technical...

    Office of Scientific and Technical Information (OSTI)

    Reference Linking at the DOE Office of Scientific and Technical Information The usefulness of electronic R&D reports, such as those accessed via the DOE Information Bridge, is ...

  15. Recent content in Linked Open Data Workshop in Washington, D...

    OpenEI (Open Energy Information) [EERE & EIA]

    Recent content in Linked Open Data Workshop in Washington, D.C. Home Name Post date sort icon Type Detailed Planning Kicks Off Jweers 27 Sep 2012 - 06:53 Blog entry Notes from the...

  16. Widget:ExternalLinkButton | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    with spaces (i.e.- btn-primary) style - add style elements, cannot change button color with this (optional) Examples Default Button Visit FWA Widget:ExternalLinkButton |...

  17. Mechanism of DNA interstrand cross-link processing by repair...

    Office of Scientific and Technical Information (OSTI)

    SciTech Connect Search Results Journal Article: Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1 Citation Details In-Document Search Title: Mechanism of ...

  18. Giant magnetic effects and oscillations in antiferromagnetic Josephson weak links

    SciTech Connect

    Gorkov, L.; Kresin, Vladimir

    2001-04-01

    Josephson junctions with an antiferromagnetic metal as a link are described. The junction can be switched off by a relatively small magnetic field. The amplitude of the current oscillates as a function of the field.

  19. Linking Legacies: Connecting the Cold War Nuclear Weapons Production

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Processes to Their Environmental Consequences | Department of Energy Linking Legacies: Connecting the Cold War Nuclear Weapons Production Processes to Their Environmental Consequences Linking Legacies: Connecting the Cold War Nuclear Weapons Production Processes to Their Environmental Consequences This report described each step in the cycle of nuclear weapons production and defined for the first time a planned disposition path for all waste streams generated prior to 1992 as a result of

  20. Links | U.S. DOE Office of Science (SC)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Links Nuclear Physics (NP) NP Home About Research Facilities Science Highlights Benefits of NP Funding Opportunities Nuclear Science Advisory Committee (NSAC) Community Resources NP Workforce Survey Results .pdf file (182KB) Links News Archives Databases Reports Workshops Nuclear Physics Related Brochures and Videos Contact Information Nuclear Physics U.S. Department of Energy SC-26/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3613 F: (301) 903-3833 E: Email

  1. Uniform Methods Project Related Links | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Project Related Links Uniform Methods Project Related Links The websites and publications listed below provide supporting information for the Uniform Methods Project and for evaluation, measurement, and verification (EM&V) of energy efficiency programs. Glossaries of EM&V Terms Federal EM&V Resources International Resources Related Standards Glossaries of EM&V Terms The following glossaries provide definitions of technical language and EM&V terms. Appendix A: Glossary of

  2. Final progress report for linking ion solvation and lithium battery

    Office of Scientific and Technical Information (OSTI)

    electrolyte properties (Technical Report) | SciTech Connect progress report for linking ion solvation and lithium battery electrolyte properties Citation Details In-Document Search Title: Final progress report for linking ion solvation and lithium battery electrolyte properties The research objective of this proposal was to provide a detailed analysis of how solvent and anion structure govern the solvation state of Li+ cations in solvent-LiX mixtures and how this, in turn, dictates the

  3. IDENTIFYING GENES CONTROLLING FERULATE CROSS-LINKING FORMATION IN GRASS

    Office of Scientific and Technical Information (OSTI)

    CELL WALLS (Technical Report) | SciTech Connect IDENTIFYING GENES CONTROLLING FERULATE CROSS-LINKING FORMATION IN GRASS CELL WALLS Citation Details In-Document Search Title: IDENTIFYING GENES CONTROLLING FERULATE CROSS-LINKING FORMATION IN GRASS CELL WALLS DESCRIPTION/ABSTRACT This proposal focuses on cell wall feruloylation and our long term goal is to identify and isolate novel genes controlling feruloylation and to characterize the phenotype of mutants in this pathway, with a spotlight on

  4. CT Scan of Earth Links Mantle Plumes with Volcanic Hotspots

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    CT Scan of Earth Links Mantle Plumes with Volcanic Hotspots CT Scan of Earth Links Mantle Plumes with Volcanic Hotspots Simulations Run at NERSC Show How Seismic Waves Travel Through Mantle September 2, 2015 Robert Sanders, rlsanders@berkeley.edu, (510) 643-6998 NERSC PI: Barbara Romanowicz Lead Institution: University of California, Berkeley Project Title: Imaging and Calibration of Mantle Structure at Global and Regional Scales Using Full-Waveform Seismic Tomography NERSC Resources Used:

  5. Voluntary Protection Program - Related Links | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    - Related Links Voluntary Protection Program - Related Links VPPPA - The Voluntary Protection Programs Participants' Association, a non- profit organization is leading the way in safety, health, and environmental excellence through cooperative efforts among labor, management, and government. http://www.vpppa.org. OSHA VPP - The United States Department of Labor, Occupational Safety and Health Administration - Voluntary Protection Program http://www.osha.gov/dcsp/vpp/index.html State VPP Programs

  6. Scientists call for antibody 'bar code' system to follow Human...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Scientists call for antibody 'bar code' system to follow Human Genome Project Alumni Link: ... Scientists call for antibody 'bar code' system to follow Human Genome Project Researchers ...

  7. Finding Balance Between Biological Groundwater Treatment and Treated Injection Water

    SciTech Connect

    Carlson, Mark A.; Nielsen, Kellin R.; Byrnes, Mark E.; Simmons, Sally A.; Morse, John J.; Geiger, James B.; Watkins, Louis E.; McFee, Phillip M.; Martins, K.

    2015-01-14

    At the U.S. Department of Energy’s Hanford Site, CH2M HILL Plateau Remediation Company operates the 200 West Pump and Treat which was engineered to treat radiological and chemical contaminants in groundwater as a result of the site’s former plutonium production years. Fluidized bed bioreactors (FBRs) are used to remove nitrate, metals, and volatile organic compounds. Increasing nitrate concentrations in the treatment plant effluent and the presence of a slimy biomass (a typical microorganism response to stress) in the FBRs triggered an investigation of nutrient levels in the system. Little, if any, micronutrient feed was coming into the bioreactors. Additionally, carbon substrate (used to promote biological growth) was passing through to the injection wells, causing biological fouling of the wells and reduced specific injectivity. Adjustments to the micronutrient feed improved microorganism health, but the micronutrients were being overfed (particularly manganese) plugging the injection wells further. Injection well rehabilitation to restore specific injectivity required repeated treatments to remove the biological fouling and precipitated metal oxides. A combination of sulfamic and citric acids worked well to dissolve metal oxides and sodium hypochlorite effectively removed the biological growth. Intensive surging and development techniques successfully removed clogging material from the injection wells. Ultimately, the investigation and nutrient adjustments took months to restore proper balance to the microbial system and over a year to stabilize injection well capacities. Carefully tracking and managing the FBRs and well performance monitoring are critical to balancing the needs of the treatment system while reducing fouling mechanisms in the injection wells.

  8. Toroidal magnet system

    DOEpatents

    Ohkawa, Tihiro; Baker, Charles C.

    1981-01-01

    In a plasma device having a toroidal plasma containment vessel, a toroidal field-generating coil system includes fixed linking coils each formed of first and second sections with the first section passing through a central opening through the containment vessel and the second section completing the linking coil to link the containment vessel. A plurality of removable unlinked coils are each formed of first and second C-shaped sections joined to each other at their open ends with their bights spaced apart. The second C-shaped section of each movable coil is removably mounted adjacent the second section of a linking coil, with the containment vessel disposed between the open ends of the first and second C-shaped sections. Electric current is passed through the linking and removable coils in opposite sense in the respective adjacent second sections to produce a net toroidal field.

  9. Proliferation profile assessment of emerging biological weapons threats. Research paper

    SciTech Connect

    Archuleta, M.G.; Bland, M.S.; Duann, T.P.; Tucker, A.B.

    1996-04-01

    This project develops a first generation biological warfare (BW) program system model for use in the DOD`s counterproliferation workstation, identifies key issues the U.S. military must address to assure its forces are prepared to fight in a BW environment, and develops a concise BW primer for use by any DOD activity requiring such information. The greatest lesson to be learned from this study is that only through the collective analysis of all the sub-systems of a suspected BW program will conclusive evidence of the program be found. Still, with current counterproliferation capabilities the U.S. may only be able to slow, not stop a motivated proliferant.

  10. A Systems Biology Platform for Characterizing Regulatory and...

    Office of Scientific and Technical Information (OSTI)

    Close Cite: Bibtex Format Close 0 pages in this document matching the terms "" Search For Terms: Enter terms in the toolbar above to search the full text of this document for ...

  11. Biocellion: Accelerating Computer Simulation of Multicellular Biological System Models

    SciTech Connect

    Kang, Seung-Hwa; Kahan, Simon H.; McDermott, Jason E.; Flann, Nicholas S.; Shmulevich, Ilya

    2014-11-01

    This paper presents Biocellion focusing on presenting the desigh rationale behind the Biocellion Application Programming Interface (API).

  12. Numerical Optimization Algorithms and Software for Systems Biology

    SciTech Connect

    Saunders, Michael

    2013-02-02

    The basic aims of this work are: to develop reliable algorithms for solving optimization problems involving large stoi- chiometric matrices; to investigate cyclic dependency between metabolic and macromolecular biosynthetic networks; and to quantify the significance of thermodynamic constraints on prokaryotic metabolism.

  13. A Systems Biology Platform for Characterizing Regulatory and...

    Office of Scientific and Technical Information (OSTI)

    that Influence and Control Microbial Hydrogen Production Citation Details In-Document ... that Influence and Control Microbial Hydrogen Production Authors: Collins, James J 1 ...

  14. A Systems Biology Platform for Characterizing Regulatory and...

    Office of Scientific and Technical Information (OSTI)

    that Influence and Control Microbial Hydrogen Production Citation Details In-Document ... that Influence and Control Microbial Hydrogen Production You are accessing a ...

  15. The interactions of peripheral membrane proteins with biological membranes

    DOE PAGES [OSTI]

    Johs, Alexander; Whited, A. M.

    2015-01-01

    The interactions of peripheral proteins with membrane surfaces are critical to many biological processes, including signaling, recognition, membrane trafficking, cell division and cell structure. On a molecular level, peripheral membrane proteins can modulate lipid composition, membrane dynamics and protein-protein interactions. Biochemical and biophysical studies have shown that these interactions are in fact highly complex, dominated by several different types of interactions, and have an interdependent effect on both the protein and membrane. Here we examine three major mechanisms underlying the interactions between peripheral membrane proteins and membranes: electrostatic interactions, hydrophobic interactions, and fatty acid modification of proteins. While experimental approachesmore » continue to provide critical insights into specific interaction mechanisms, emerging bioinformatics resources and tools contribute to a systems-level picture of protein-lipid interactions. Through these recent advances, we begin to understand the pivotal role of protein-lipid interactions underlying complex biological functions at membrane interfaces.« less

  16. The interactions of peripheral membrane proteins with biological membranes

    SciTech Connect

    Johs, Alexander; Whited, A. M.

    2015-01-01

    The interactions of peripheral proteins with membrane surfaces are critical to many biological processes, including signaling, recognition, membrane trafficking, cell division and cell structure. On a molecular level, peripheral membrane proteins can modulate lipid composition, membrane dynamics and protein-protein interactions. Biochemical and biophysical studies have shown that these interactions are in fact highly complex, dominated by several different types of interactions, and have an interdependent effect on both the protein and membrane. Here we examine three major mechanisms underlying the interactions between peripheral membrane proteins and membranes: electrostatic interactions, hydrophobic interactions, and fatty acid modification of proteins. While experimental approaches continue to provide critical insights into specific interaction mechanisms, emerging bioinformatics resources and tools contribute to a systems-level picture of protein-lipid interactions. Through these recent advances, we begin to understand the pivotal role of protein-lipid interactions underlying complex biological functions at membrane interfaces.

  17. Towards a Semantic Lexicon for Biological Language Processing

    DOE PAGES [OSTI]

    Verspoor, Karin

    2005-01-01

    This paper explores the use of the resources in the National Library of Medicine's Unified Medical Language System (UMLS) for the construction of a lexicon useful for processing texts in the field of molecular biology. A lexicon is constructed from overlapping terms in the UMLS SPECIALIST lexicon and the UMLS Metathesaurus to obtain both morphosyntactic and semantic information for terms, and the coverage of a domain corpus is assessed. Over 77% of tokens in the domain corpus are found in the constructed lexicon, validating the lexicon's coverage of the most frequent terms in the domain and indicating that the constructedmore » lexicon is potentially an important resource for biological text processing.« less

  18. Cosmic heavy ion tracks in mesoscopic biological test objects

    SciTech Connect

    Facius, R.

    1994-12-31

    Since more than 20 years ago, when the National Academy of Sciences and the National Research Council of the U.S.A. released their report on `HZE particle effects in manned spaced flight`, it has been emphasized how difficult - if not even impossible - it is to assess their radiobiological impact on man from conventional studies where biological test organisms are stochastically exposed to `large` fluences of heavy ions. An alternative, competing approach had been realized in the BIOSTACK experiments, where the effects of single cosmic as well as accelerator - heavy ions on individual biological test organisms could be investigated. Although presented from the beginning as the preferable approach for terrestrial investigations with accelerator heavy ions too (`The BIOSTACK as an approach to high LET radiation research`), only recently this insight is gaining more widespread recognition. In space flight experiments, additional constraints imposed by the infrastructure of the vehicle or satellite further impede such investigations. Restrictions concern the physical detector systems needed for the registration of the cosmic heavy ions` trajectories as well as the biological systems eligible as test organisms. Such optimized procedures and techniques were developed for the investigations on chromosome aberrations induced by cosmic heavy ions in cells of the stem meristem of lettuce seeds (Lactuca sativa) and for the investigation of the radiobiological response of Wolffia arriza, which is the smallest flowering (water) plant. The biological effects were studied by the coworkers of the Russian Institute of Biomedical Problems (IBMP) which in cooperation with the European Space Agency ESA organized the exposure in the Biosatellites of the Cosmos series.

  19. End-to-end automated microfluidic platform for synthetic biology: from design to functional analysis

    DOE PAGES [OSTI]

    Linshiz, Gregory; Jensen, Erik; Stawski, Nina; Bi, Changhao; Elsbree, Nick; Jiao, Hong; Kim, Jungkyu; Mathies, Richard; Keasling, Jay D.; Hillson, Nathan J.

    2016-02-02

    Synthetic biology aims to engineer biological systems for desired behaviors. The construction of these systems can be complex, often requiring genetic reprogramming, extensive de novo DNA synthesis, and functional screening. Here, we present a programmable, multipurpose microfluidic platform and associated software and apply the platform to major steps of the synthetic biology research cycle: design, construction, testing, and analysis. We show the platform’s capabilities for multiple automated DNA assembly methods, including a new method for Isothermal Hierarchical DNA Construction, and for Escherichia coli and Saccharomyces cerevisiae transformation. The platform enables the automated control of cellular growth, gene expression induction, andmore » proteogenic and metabolic output analysis. Finally, taken together, we demonstrate the microfluidic platform’s potential to provide end-to-end solutions for synthetic biology research, from design to functional analysis.« less

  20. Algal Biology Program at Los Alamos

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Algal Biology Program at Los Alamos gets a star October 11, 2011 LOS ALAMOS, New Mexico, October 11, 2011-Richard Sayre, one of the nation's top specialists in algae and...