National Library of Energy BETA

Sample records for ky mi ne

  1. BooNE: Picture Gallery

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Picture Gallery BooNE Collaboration Members of the BooNE collaboration Civil Construction Pictorial progress of BooNE civil construction work Detector Installation Pictorial progress of MiniBooNE detector installation BooNE Scrapbook A selection from BooNE Audio Gallery Horn Concerto The Horn Concerto is a recording of the BooNE horn and the NuMI horn sounding at the same time. The rat-a-tat is BooNE; the syncopated boom is NuMI.

  2. 19Ne

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Ne β+-Decay Evaluated Data Measurements 1939WH02: 19Ne. 1952SC15: 19Ne. 1954JO21: 19Ne. 1954NA29: 19Ne. 1957AL29: 19Ne. 1957PE12: 19Ne. 1958WE25: 19Ne. 1960JA12: 19Ne; measured not abstracted; deduced nuclear properties. 1960WA04: 19Ne; measured not abstracted; deduced nuclear properties. 1962EA02: 19Ne; measured not abstracted; deduced nuclear properties. 1964VA23: 19Ne; measured not abstracted; deduced nuclear properties. 1968GO10: 19Ne; measured T1/2. 1972LE33: 19Ne; measured K/β+ ratios.

  3. 18Ne

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Ne β+-Decay Evaluated Data Measurements 1954GO17: 18Ne. 1961BU05: 18Ne; measured not abstracted; deduced nuclear properties. 1961EC02: 18Ne; measured not abstracted; deduced nuclear properties. 1963FR10: 18Ne; measured not abstracted; deduced nuclear properties. 1965FR09: 18Ne; measured not abstracted; deduced nuclear properties. 1968GO05: 18Ne; measured Eγ, Iγ; deduced Iβ, log ft. 18F deduced levels, branching ratios. 1970AL11: 18Ne; measured T1/2; deduced log ft, β-branching. 1970AS06,

  4. BooNE: About BooNE

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    BooNE Collaboration BooNE Experiment BooNE vs MiniBooNE Interesting Facts Posters Virtual Tour Picture Gallery News Articles BooNE photo montage Technical Information BooNE...

  5. 15Ne

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Ne Ground-State Decay Evaluated Data Measured Ground-State Γcm for 15Ne Adopted value: 0.59 MeV (2014WA09) Measured Mass Excess for 15Ne Adopted value: 40215 ± 69 keV (2014WA09) Measurements 2014WA09: C(17Ne, 2p)15Ne, E = 500 MeV/nucleon; measured reaction products; deduced fractional energy spectra, J, π, energy levels, atomic mass excess. 15Ne(2p); measured decay products, Ep, Ip; deduced implications for 13O + p + p system. Back to Top Back to Ground-State Decays

  6. 17Ne

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Ne β+-Decay Evaluated Data Measurements 1964MC16: 17Ne; measured not abstracted; deduced nuclear properties. 1966HA22: 17Ne; deduced log ft. 1967ES02: 17Ne; measured not abstracted; deduced nuclear properties. 1967FI10: 17Ne. 1971ESZR, 1971HA05: 17Ne; measured β-delayed proton spectra, Eγ, Iγ, T1/2, pγ-coin; deduced log ft. 17F deduced levels, antianalog state, isospin mixing. 1988BO39: 17Ne(β+p), (β+α); measured T1/2, β-delayed E(p), E(α), I(p), I(α), β(particle)-coin. 17Ne deduced

  7. 16Ne

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Ne Ground-State Decay Evaluated Data Measured Ground-State Γcm for 16Ne Adopted value: 122 ± 37 keV (1993TI07) Measured Mass Excess for 16Ne Adopted value: 23996 ± 20 keV (2003AU02) Measurements 1971MAXQ: 16O(π+, π-); measured particle spectra, σ. 1977HO13: 16O(π+, π-), E = 145 MeV; measured σ; deduced Q. 16Ne deduced mass excess. 1977KEZX: 20Ne(α, 8He), E = 118 MeV; measured σ. 16Ne deduced levels, mass excess. 1978BU09: 16O(π+, π-), E = 145 MeV; measured σ. 16Ne deduced mass

  8. A=19Ne (1978AJ03)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    8AJ03) (See Energy Level Diagrams for 19Ne) GENERAL: See (1972AJ02) and Table 19.24 [Table of Energy Levels] (in PDF or PS). Nuclear models: (1972EN03, 1972NE1B, 1972WE01, 1973DE13, 1977BU05). Electromagnetic transitions: (1972EN03, 1972LE06, 1973HA53, 1973PE09, 1977BU05). Special states: (1972EN03, 1972GA14, 1972HI17, 1972NE1B, 1972WE01, 1977BU05, 1977SC08). Complex reactions involving 19Ne: (1976HI05, 1977BU05). Astrophsyical questions: (1973CL1E). Muon capture: (1972MI11). Pion capture and

  9. The MicroBooNE Experiment Ryan Grosso

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    MicroBooNE Experiment Ryan Grosso University of Cincinnati On Behalf of The MicroBooNE Collaboration MicroBooNE ● Liquid Argon (LAr) Time-Projection Chamber (TPC) with 87 ton active volume. ● Stationed at Fermilab in the Booster Neutrino beam ● Major goals of MicroBooNE: ○ Investigate MiniBooNE's low energy excess ○ Wide range of cross section measurements of neutrinos on Ar ○ R&D for future large LAr detectors Booster Neutrino Beam NuMI Beam Tevatron 2 MiniBooNE Low Energy

  10. High Performance Without Increased Cost: Urbane Homes, Louisville, KY -

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Building America Top Innovation | Department of Energy High Performance Without Increased Cost: Urbane Homes, Louisville, KY - Building America Top Innovation High Performance Without Increased Cost: Urbane Homes, Louisville, KY - Building America Top Innovation Photo of a Housing Award logo with a home. This Top Innovation highlights Building America field projects that demonstrated minimal or cost-neutral impacts for high-performance homes and that have significantly influenced the housing

  11. Beyond standard model searches in the MiniBooNE experiment

    SciTech Connect

    Katori, Teppei; Conrad, Janet M.

    2014-08-05

    The MiniBooNE experiment has contributed substantially to beyond standard model searches in the neutrino sector. The experiment was originally designed to test the <mi mathvariant='normal'>Δmi>m>2~1eV2 region of the sterile neutrino hypothesis by observing <mimi><mi>e>(<mimi>-<mi>e>) charged current quasielastic signals from a <mimi><mi>μ>(<mimi>-<mi>μ>) beam. MiniBooNE observed excesses of <mimi>e> and <mimi>-<mi>e> candidate events in neutrino and antineutrino mode, respectively. To date, these excesses have not been explained within the neutrino standard model (<mi>ν>SM); the standard model extended for three massive neutrinos. Confirmation is required by future experiments such as MicroBooNE. MiniBooNE also provided an opportunity for precision studies of Lorentz violation. The results set strict limits for the first time on several parameters of the standard-model extension, the generic formalism for considering Lorentz violation. Most recently, an extension to MiniBooNE running, with a beam tuned in beam-dump mode, is being performed to search for dark sector particles. In addition, this review describes these studies, demonstrating that short baseline neutrino experiments

  12. NE-20

    Office of Legacy Management (LM)

    hi v. !&-2:. /qL lo 1 OCT 2 9 1984 NE-20 -. Authorization for Remedial Action of the Ashland 2 Site, Tonawanda, New York f! Joe LaGrone, Manager Oak Ridge Operations Office Based on the Aerial Radiological Survey (Attachment 1) and a "walk-on" radiologlcal survey (Attachment 2 , excerpted from the ORNL draft report "Ground-Level Investigation of Anomalous Gamma Radiation Levels in the Tonawanda, New York, Area," January 1980), the property identified as Ashland 2 is

  13. MicroBooNE

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    MicroBooNE MicroBooNE Investigating the field of high energy physics through experiments that ... R. Dharmapalan et al. MiniBooNE Collaboration, arXiv:1211.2258 hep-ex (2012).

  14. BooNE Experiment

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Experiment Goals of BooNE BooNE in a Nutshell Making Neutrinos Detecting Neutrinos schematic of BooNE experiment A sample event (3M animated PDF file) A cosmic ray event as displayed by the MiniBooNE detector.

  15. BooNE Collaboration

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Collaboration The BooNE collaboration consists of approximately sixty-five physicists from 13 institutions. While small on the scale of high energy physics experiments, BooNE thrives from the diversity of its membership. This includes scientists from national laboratories, research universities, predominantly undergraduate institutions, as well as a high school physics teacher. List of Collaborators The BooNE Collaboration The BooNE Collaboration

  16. MicroBooNE

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    MicroBooNE MicroBooNE Investigating the field of high energy physics through experiments that strengthen our fundamental understanding of matter, energy, space, and time. Get Expertise Rajan Gupta (505) 667-7664 Email Bruce Carlsten (505) 667-5657 Email MicroBooNE schematic drawing Figure 1: A schematic drawing of the MicroBooNE liquid argon TPC detector. The main goals of the MicroBooNE experiment are: (1) to demonstrate the capabilities of a liquid argon TPC in the reconstruction of neutrino

  17. SciBooNE/MiniBooNE

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    MiniBooNE 800t mineral oil Cherenkov detector ... 0.30 Combined with world K+ production data, reduces error on ... updates... Higher stats for all MC samples, ...

  18. MICROBOONE PHYSICS Ben Carls Fermilab MicroBooNE Physics Outline

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    PHYSICS Ben Carls Fermilab MicroBooNE Physics Outline * The detector and beam - MicroBooNE TPC - Booster and NuMI beams at Fermilab * Oscillation physics - Shed light on the MiniBooNE low energy excess * Low energy neutrino cross sections * Non-accelerator topics - Supernova neutrino detection - Proton decay backgrounds 2 B. Carls, Fermilab MicroBooNE Physics MicroBooNE Detector * 60 ton fiducial volume (of 170 tons total) liquid Argon TPC * TPC consists of 3 planes of wires; vertical Y, ±60°

  19. BooNE: Posters

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Posters What's a Neutrino? How neutrinos fit into our understanding of the universe. Recipe for a Neutrino Beam Start with some protons... concocting the MiniBooNE beam. The MiniBooNE Detector Tracking the traces of neutrino interactions. Of Neutrino Mass, and Oscillation What oscillates in neutrino oscillations, and why it matters

  20. A=18Ne (1972AJ02)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    2AJ02) (See Energy Level Diagrams for 18Ne) GENERAL: See Table 18.23 [Table of Energy Levels] (in PDF or PS). Shell and cluster model calculations: (1957WI1E, 1969BE1T, 1970BA2E, 1970EL08, 1970HA49, 1972KA01). Electromagnetic transitions: (1970EL08, 1970HA49). Special levels: (1966MI1G, 1969KA29, 1972KA01). Pion reactions: (1965PA1F). Other theoretical calculations: (1965GO1F, 1966KE16, 1968BA2H, 1968BE1V, 1968MU1B, 1968NE1C, 1968VA1J, 1968VA24, 1969BA1Z, 1969GA1G, 1969KA29, 1969MU09, 1969RA28,

  1. A=18Ne (1978AJ03)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    8AJ03) (See Energy Level Diagrams for 18Ne) GENERAL: See also (1972AJ02) and Table 18.22 [Table of Energy Levels] (in PDF or PS). Model calculations: (1972EN03, 1974LO04). Electromagnetic transitions: (1970SI1J, 1972EN03, 1974LO04, 1976SH04, 1977BR03, 1977SA13). Special states: (1972EN03, 1972RA08). Muon- and pion-induced capture and reactions (See also reaction 5.): (1972MI11, 1974LI1N, 1975LI04, 1976HE1G, 1977MA2Q, 1977RO1U). Other theoretical calculations: (1970SI1J, 1972CA37, 1972RA08,

  2. 20Ne Cross Section

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    p, X) (Current as of 05/15/2012) NSR Reaction Ep (MeV) Cross Section File X4 Dataset Date Added 1981DY03 20Ne(p, p'γ): σ for production of γ-rays threshold - 23 1.63-MeV γ-rays X4 03/15/2011 20Ne(p, pαγ): σ for production of γ-rays threshold - 23 6.13-MeV γ-rays 1975RO08 20Ne(p, γ): S-factors 0.37 - 2.10 Direct Capture (DC) → 332-keV state, DC → 2425-keV state, tail of 2425-keV state X4 04/19/2011 20Ne(p, γ): differential σ at θγ = 90° DC → 332-keV state, 332-keV state →

  3. File:USDA-CE-Production-GIFmaps-KY.pdf | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    KY.pdf Jump to: navigation, search File File history File usage Kentucky Ethanol Plant Locations Size of this preview: 776 600 pixels. Full resolution (1,650 1,275 pixels,...

  4. MiniBooNE

    SciTech Connect

    Mahn, Kendall Brianna Mcconnel; /Columbia U.

    2007-03-01

    MiniBooNE is a short baseline neutrino experiment designed to confirm or refute the LSND observed excess of electron anti neutrinos in a muon anti neutrino beam. The experimental setup, data samples, and oscillation fit method are discussed. Although the result was not public at the time of the talk, MiniBooNE has since published results, which are discussed briefly as well.

  5. BooNE versus MiniBooNE

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    vs MiniBooNE MiniBooNE refers to the first phase of the BooNE experiment and describes the neutrino oscillation measurements that will be made with a single detector. If neutrino oscillations are observed, then MiniBooNE will be upgraded to a second detector. This 2-detector arrangement (BooNE) will fulfill the second and final stage of the experiment. The BooNE experiment sets out to definitively explore the neutrino oscillation signal reported by the Los Alamos LSND experiment. MiniBooNE

  6. 20Ne Cross Section

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    20Ne(α, X) (Current as of 02/08/2016) NSR Reaction Eα (MeV) Cross Section File X4 Dataset Date Added 1983SC17 20Ne(α, γ): deduced S-factor of capture σ 0.55 - 3.2 X4 09/15/2011 1997WI12 20Ne(α, γ): deduced primary transitions yield 1.64 - 2.65 X4 09/15/2011 1999KO34 20Ne(α, γ): γ-ray yield for the transition 1.9 - 2.8 g.s. 01/03/2012 1369 keV g.s. 10917 keV g.s., 1369 keV 11016 keV g.s. 1975KU06 20Ne(α, γ): σ 2.5 - 20 X4 09/15/2011 1968HI02 20Ne(α, γ): σ 3 - 6 X4 09/15/2011

  7. Microsoft PowerPoint - MiniBooNE Neutrino 2008

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Oscillation Searches Steve Brice (Fermilab) for the MiniBooNE Collaboration Neutrino 2008 Neutrino 2008 Steve Brice (FNAL) 2 Outline * Electron Neutrino Appearance - Oscillation Result - π 0 Rate Measurement - Combining Analyses - Compatibility of High ∆m 2 Measurements - Low Energy Electron Candidate Excess - Data from NuMI Beam * Muon Neutrino Disappearance * Anti-Electron Neutrino Appearance * Summary Neutrino 2008 Steve Brice (FNAL) 3 2 National Laboratories, 14 Universities, 80

  8. BooNE: Interesting Facts

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Interesting Facts About the BooNE experiment: BooNE is the only experiment to search the entire range covered by the LSND oscillation signal. First proposed in 1997, BooNE will be ready to collect data in summer, 2002. The BooNE collaboration is small by high energy physics standards, having 65 physicists from 13 instiutions. If BooNE detects a supernova, it will send an automatic signal to telescopes around the world describing its position. BooNE collaboration - click to enlarge About the

  9. Measurement of the direct <mi>CP> -violating parameter <mi>Ami><mi>CP> in the decay <mi>D>+<mi>Kmi>-<mimi>+<mi>π>+

    SciTech Connect

    Abazov, V. M.; Abbott, B.; Acharya, B. S.; Adams, M.; Adams, T.; Agnew, J. P.; Alexeev, G. D.; Alkhazov, G.; Alton, A.; Askew, A.; Atkins, S.; Augsten, K.; Avila, C.; Badaud, F.; Bagby, L.; Baldin, B.; Bandurin, D. V.; Banerjee, S.; Barberis, E.; Baringer, P.; Bartlett, J. F.; Bassler, U.; Bazterra, V.; Bean, A.; Begalli, M.; Bellantoni, L.; Beri, S. B.; Bernardi, G.; Bernhard, R.; Bertram, I.; Besançon, M.; Beuselinck, R.; Bhat, P. C.; Bhatia, S.; Bhatnagar, V.; Blazey, G.; Blessing, S.; Bloom, K.; Boehnlein, A.; Boline, D.; Boos, E. E.; Borissov, G.; Borysova, M.; Brandt, A.; Brandt, O.; Brock, R.; Bross, A.; Brown, D.; Bu, X. B.; Buehler, M.; Buescher, V.; Bunichev, V.; Burdin, S.; Buszello, C. P.; Camacho-Pérez, E.; Casey, B. C. K.; Castilla-Valdez, H.; Caughron, S.; Chakrabarti, S.; Chan, K. M.; Chandra, A.; Chapon, E.; Chen, G.; Cho, S. W.; Choi, S.; Choudhary, B.; Cihangir, S.; Claes, D.; Clutter, J.; Cooke, M.; Cooper, W. E.; Corcoran, M.; Couderc, F.; Cousinou, M. -C.; Cutts, D.; Das, A.; Davies, G.; de Jong, S. J.; De La Cruz-Burelo, E.; Déliot, F.; Demina, R.; Denisov, D.; Denisov, S. P.; Desai, S.; Deterre, C.; DeVaughan, K.; Diehl, H. T.; Diesburg, M.; Ding, P. F.; Dominguez, A.; Dubey, A.; Dudko, L. V.; Duperrin, A.; Dutt, S.; Eads, M.; Edmunds, D.; Ellison, J.; Elvira, V. D.; Enari, Y.; Evans, H.; Evdokimov, V. N.; Fauré, A.; Feng, L.; Ferbel, T.; Fiedler, F.; Filthaut, F.; Fisher, W.; Fisk, H. E.; Fortner, M.; Fox, H.; Fuess, S.; Garbincius, P. H.; Garcia-Bellido, A.; García-González, J. A.; Gavrilov, V.; Geng, W.; Gerber, C. E.; Gershtein, Y.; Ginther, G.; Gogota, O.; Golovanov, G.; Grannis, P. D.; Greder, S.; Greenlee, H.; Grenier, G.; Gris, Ph.; Grivaz, J. -F.; Grohsjean, A.; Grünendahl, S.; Grünewald, M. W.; Guillemin, T.; Gutierrez, G.; Gutierrez, P.; Haley, J.; Han, L.; Harder, K.; Harel, A.; Hauptman, J. M.; Hays, J.; Head, T.; Hebbeker, T.; Hedin, D.; Hegab, H.; Heinson, A. P.; Heintz, U.; Hensel, C.; Heredia-De La Cruz, I.; Herner, K.; Hesketh, G.; Hildreth, M. D.; Hirosky, R.; Hoang, T.; Hobbs, J. D.; Hoeneisen, B.; Hogan, J.; Hohlfeld, M.; Holzbauer, J. L.; Howley, I.; Hubacek, Z.; Hynek, V.; Iashvili, I.; Ilchenko, Y.; Illingworth, R.; Ito, A. S.; Jabeen, S.; Jaffré, M.; Jayasinghe, A.; Jeong, M. S.; Jesik, R.; Jiang, P.; Johns, K.; Johnson, E.; Johnson, M.; Jonckheere, A.; Jonsson, P.; Joshi, J.; Jung, A. W.; Juste, A.; Kajfasz, E.; Karmanov, D.; Katsanos, I.; Kaur, M.; Kehoe, R.; Kermiche, S.; Khalatyan, N.; Khanov, A.; Kharchilava, A.; Kharzheev, Y. N.; Kiselevich, I.; Kohli, J. M.; Kozelov, A. V.; Kraus, J.; Kumar, A.; Kupco, A.; Kurča, T.; Kuzmin, V. A.; Lammers, S.; Lebrun, P.; Lee, H. S.; Lee, S. W.; Lee, W. M.; Lei, X.; Lellouch, J.; Li, D.; Li, H.; Li, L.; Li, Q. Z.; Lim, J. K.; Lincoln, D.; Linnemann, J.; Lipaev, V. V.; Lipton, R.; Liu, H.; Liu, Y.; Lobodenko, A.; Lokajicek, M.; Lopes de Sa, R.; Luna-Garcia, R.; Lyon, A. L.; Maciel, A. K. A.; Madar, R.; Magaña-Villalba, R.; Malik, S.; Malyshev, V. L.; Mansour, J.; Martínez-Ortega, J.; McCarthy, R.; McGivern, C. L.; Meijer, M. M.; Melnitchouk, A.; Menezes, D.; Mercadante, P. G.; Merkin, M.; Meyer, A.; Meyer, J.; Miconi, F.; Mondal, N. K.; Mulhearn, M.; Nagy, E.; Narain, M.; Nayyar, R.; Neal, H. A.; Negret, J. P.; Neustroev, P.; Nguyen, H. T.; Nunnemann, T.; Orduna, J.; Osman, N.; Osta, J.; Pal, A.; Parashar, N.; Parihar, V.; Park, S. K.; Partridge, R.; Parua, N.; Patwa, A.; Penning, B.; Perfilov, M.; Peters, Y.; Petridis, K.; Petrillo, G.; Pétroff, P.; Pleier, M. -A.; Podstavkov, V. M.; Popov, A. V.; Prewitt, M.; Price, D.; Prokopenko, N.; Qian, J.; Quadt, A.; Quinn, B.; Ratoff, P. N.; Razumov, I.; Ripp-Baudot, I.; Rizatdinova, F.; Rominsky, M.; Ross, A.; Royon, C.; Rubinov, P.; Ruchti, R.; Sajot, G.; Sánchez-Hernández, A.; Sanders, M. P.; Santos, A. S.; Savage, G.; Savitskyi, M.; Sawyer, L.; Scanlon, T.; Schamberger, R. D.; Scheglov, Y.; Schellman, H.; Schwanenberger, C.; Schwienhorst, R.; Sekaric, J.; Severini, H.; Shabalina, E.; Shary, V.; Shaw, S.; Shchukin, A. A.; Simak, V.; Skubic, P.; Slattery, P.; Smirnov, D.; Snow, G. R.; Snow, J.; Snyder, S.; Söldner-Rembold, S.; Sonnenschein, L.; Soustruznik, K.; Stark, J.; Stoyanova, D. A.; Strauss, M.; Suter, L.; Svoisky, P.; Titov, M.; Tokmenin, V. V.; Tsai, Y. -T.; Tsybychev, D.; Tuchming, B.; Tully, C.; Uvarov, L.; Uvarov, S.; Uzunyan, S.; Van Kooten, R.; van Leeuwen, W. M.; Varelas, N.; Varnes, E. W.; Vasilyev, I. A.; Verkheev, A. Y.; Vertogradov, L. S.; Verzocchi, M.; Vesterinen, M.; Vilanova, D.; Vokac, P.; Wahl, H. D.; Wang, M. H. L. S.; Warchol, J.; Watts, G.; Wayne, M.; Weichert, J.; Welty-Rieger, L.; Williams, M. R. J.; Wilson, G. W.; Wobisch, M.; Wood, D. R.; Wyatt, T. R.; Xie, Y.; Yamada, R.; Yang, S.; Yasuda, T.; Yatsunenko, Y. A.; Ye, W.; Ye, Z.; Yin, H.; Yip, K.; Youn, S. W.; Yu, J. M.; Zennamo, J.; Zhao, T. G.; Zhou, B.; Zhu, J.; Zielinski, M.; Zieminska, D.; Zivkovic, L.

    2014-12-01

    We measure the direct mi>Cmi>mi>P>-violating parameter mi>Ami>mi>Cmi>mi>Pmi> for the decay of the charged charm meson, mi>Dmi>+mi>Kmi>-mi>πmi>+mi>πmi>+ (and charge conjugate), using the full 10.4 mi>fbmi>-1 sample of mi>p>mi>p>¯ collisions at mi>smi>=1.96 mi>TeVmi> collected by the D0 detector at the Fermilab Tevatron collider. We extract the raw reconstructed charge asymmetry by fitting the invariant mass distributions for the sum and difference of charge-specific samples. This quantity is then corrected for detector-related asymmetries using data-driven methods and for possible physics asymmetries (from mi>B>mi>D

  10. BooNE: Booster Neutrino Experiment

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Picture Gallery BooNE Collaboration Members of the BooNE collaboration Civil Construction Pictorial progress of BooNE civil construction work Detector Installation Pictorial...

  11. BooNE: Booster Neutrino Experiment

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Booster Neutrino Experiment (BooNE) Goals of BooNE BooNE in a Nutshell Making Neutrinos Detecting Neutrinos

  12. BooNE: Booster Neutrino Experiment

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Progress in Delivering Beam to MiniBooNE

  13. The MicroBooNE Experiment - Collaboration

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    The DOE Tours MicroBooNE! - Nov. 27, 2012

  14. BooNE: Booster Neutrino Experiment

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Booster Neutrino Experiment (BooNE) BooNE vs MiniBooNE Interesting Facts Posters Virtual Tour Picture Gallery News Articles Technical Information BooNE Proposal Original...

  15. Unitary Structure of the QCD Sum Rules and KYN and KY{xi} Couplings

    SciTech Connect

    Aliev, T.; Ozpineci, A.; Yakovlev, S. B.; Zamiralov, V. S.

    2006-01-12

    New relations between QCD Borel sum rules for strong coupling constants of K-mesons to baryons are derived. It is shown that starting from the sum rule for the coupling constants g{pi}{sigma}{sigma} and g{pi}{sigma}{lambda} it is straightforward to obtain corresponding sum rules for the gKYN, gKY{xi} couplings, Y = {sigma}, {lambda}.

  16. US NE MA Site Consumption

    Energy Information Administration (EIA) (indexed site)

    NE MA Site Consumption million Btu $0 $500 $1,000 $1,500 $2,000 $2,500 $3,000 US NE MA Expenditures dollars ALL ENERGY average per household (excl. transportation) 0 2,000 4,000 6,000 8,000 10,000 12,000 US NE MA Site Consumption kilowatthours $0 $250 $500 $750 $1,000 $1,250 $1,500 US NE MA Expenditures dollars ELECTRICITY ONLY average per household * Massachusetts households use 109 million Btu of energy per home, 22% more than the U.S. average. * The higher than average site consumption

  17. MiniBooNE E. D. Zimmerman

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    SciBooNE Detector TargetHorn SciBooNE constraint reduces error at MiniBooNE * Flux errors become 1-2% level: negligible for this analysis * Cross-section errors reduced, but...

  18. MiniBooNE E. D. Zimmerman

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    from MiniBooNE * MiniBooNE * Neutrino cross-sections * Quasielastic and elastic scattering * Hadron production channels * Neutrino Oscillations * Antineutrino Oscillations...

  19. BooNE: Booster Neutrino Experiment

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    MiniBooNE-darkmatter collaboration Original MiniBooNE collaboration From script reading a simple data base, last updated 2008. from inspirehep.net Booster Neutrino...

  20. A=14Ne (1981AJ01)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    1AJ01) (Not illustrated) 14Ne has not been observed. See (1976BE1V

  1. BooNE News Articles

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    News Articles FermiNews Fermilab's biweekly magazine (several stories) Beam Line: Special Neutrino Issue A special issue of SLAC's quarterly magazine. Earth & Sky "Catching Ghost Particles": Interview with Janet Conrad Columbia Magazine "The Nature of the Neutrino": MiniBooNE and neutrinos The Los Angeles Times "It's No Small Matter": K. C. Cole's article detailing her summer 2003 stint at Fermilab working on MiniBooNE [text only]

  2. The MicroBooNE Experiment - Collaboration

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    MicroBooNE In the News MicroBooNE internal newletters (password protected) National Lab Science Day (public debut of virtual MicroBooNE), Fermilab News, 04/29/16 MicroBooNE Project Team Recognized by Department of Energy, Fermilab News, 04/08/16 The Hidden Neutrino, Symmetry Magazine, 03/01/16 Booster Neutrino Beam Reaches Record Beam Intensity, Fermilab This Week, 02/02/16 MicroBooNE Sees First Accelerator-Born Neutrinos, Fermilab Today, 11/02/15 MicroBooNE Sees First Accelerator-Born

  3. The MicroBooNE Experiment - Collaboration

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Collaboration (*) The MicroBooNE spokespeople are Bonnie Fleming (Yale) and Sam Zeller (FNAL) (+) The MicroBooNE project manager was Gina Rameika Updated collaboration list for presentations: powerpoint pdf map MicroBooNE author list: pdf, LATeX, plain text MicroBooNE detector paper author list: pdf, LATeX collaboration photo MicroBooNE organizational chart MicroBooNE contact list (password required) </ br> (IB) = Institutional Board representative (this is the PI for each institution)

  4. BooNE: Booster Neutrino Experiment

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Interesting Facts About the Booster Neutrino Experiment (BooNE): BooNE is the only experiment to search the entire range covered by the LSND oscillation signal. First proposed in 1997, BooNE has been collecting data since August 2002. The BooNE collaboration is small by high energy physics standards, comprising 75 physicists from 16 instiutions. If BooNE detects a supernova, it will send an automatic signal to telescopes around the world describing its position. BooNE collaboration - click to

  5. ICARUS/MicroBooNE

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ) ICARUS/MicroBooNE ν ( Φ 0.0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 µ ν µ ν e ν e ν

  6. US ENC MI Site Consumption

    Energy Information Administration (EIA) (indexed site)

    MI Site Consumption million Btu $0 $500 $1,000 $1,500 $2,000 $2,500 US ENC MI Expenditures dollars ALL ENERGY average per household (excl. transportation) 0 2,000 4,000 6,000 8,000 10,000 12,000 US ENC MI Site Consumption kilowatthours $0 $250 $500 $750 $1,000 $1,250 $1,500 US ENC MI Expenditures dollars ELECTRICITY ONLY average per household * Michigan households use 123 million Btu of energy per home, 38% more than the U.S. average. * High consumption, combined with low costs for heating fuels

  7. About the MicroBooNE Experiment

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    MicroBooNE The MicroBooNE collaboration is currently operating a large 170-ton liquid Argon Time Projection Chamber (LArTPC) that is located on the Booster neutrino beam line at...

  8. BooNE: Booster Neutrino Experiment

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Status of the Search for Neutrino Oscillations with MiniBooNE G. Mills SNAC 2011 September 26, 2011 Virginia Tech MiniBooNE T. Katori Crimean conference September 3, 2011 Crimea, ...

  9. BooNE: Booster Neutrino Experiment

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Data Releases This page provides MiniBooNE data (histograms, error matrices, ntuples, etc) released in association with particular publications. Only the subset of MiniBooNE papers...

  10. MiniBooNE Nuebar Data Release

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Event Excess in the MiniBooNE Search for bar numu rightarrow bar nue Oscillations", arXiv:1007.1150 hep-ex,Phys.Rev.Lett.105,181801 (2010) The following MiniBooNE...

  11. BooNE: Booster Neutrino Experiment

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    by the Los Alamos LSND experiment. MiniBooNE represents the first phase for the BooNE collaboration and consists of a 1 GeV neutrino beam and a single, 800-ton mineral oil...

  12. BooNE: Booster Neutrino Experiment

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    (505) 695 8364 BooNE Experiment: contact-boone@fnal.gov Current Shifter: (505) 500 5511 Detector Enclosure: (630) 840 6881 or 6081 BooNE Collaborators and Associates:...

  13. A=14Ne (1986AJ01)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    6AJ01) (Not illustrated) 14Ne, 14Na and 14Mg have not been observed. See (1983ANZQ

  14. A=14Ne (1991AJ01)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    91AJ01) (Not illustrated) 14Ne, 14Na and 14Mg have not been observed. See (1986AN07

  15. The MicroBooNE Experiment - Collaboration

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    MicroBooNE Collaboration Photos Click on image to view larger version April 2016 October 2014

  16. A=18Ne (1959AJ76)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    59AJ76) (Not illustrated) Theory: See (RA57). 1. 18Ne(β+)18F Qm = 4.227 The maximum energy of the positrons is 3.2 ± 0.2 MeV, the half-life is 1.6 ± 0.2 sec: log ft = 2.9 ± 0.2 (GO54D). See also (DZ56). 2. 16O(3He, n)18Ne Qm = -2.966 See (KU53A). 3. 19F(p, 2n)18Ne Qm = -15.424 See (GO54D). 4. 20Ne(p, t)18Ne Qm = -19.812 Not reported

  17. A=17Ne (1977AJ02)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    7AJ02) (See the Isobar Diagram for 17Ne) GENERAL: See also (1971AJ02) and Table 17.20 [Table of Energy Levels] (in PDF or PS). Theory and reviews: (1971HA1Y, 1973HA77, 1973RE17, 1975BE31). Mass of 17Ne: The mass excess of 17Ne, determined from a measurement of the Q-value of 20Ne(3He, 6He)17Ne is 16.48 ± 0.05 MeV (1970ME11, 1972CE1A). Then 17Ne - 17F = 14.53 MeV and Eb for p, 3He and α are, respectively, 1.50, 6.46 and 9.05 MeV. See also (1971AJ02). 1. (a) 17Ne(β+)17F* → 16O + p Qm = 13.93

  18. Ne

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    m er of 2002, the cross sections for an 8 GeV proton beam on Be were m easured by the HARP ex perim ent at CERN. Harp Setup Intro ductio n Im po rtant s te ps s ince las t re v...

  19. Hallam Nuclear Power Facility, NE

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Hallam Nuclear Power Facility, NE 1969 1998 2. Piqua Nuclear Power Facility, OH 1969 1998 3. Bayo Canyon, NM 1982 1998 4. Kellex/Pierpont, NJ 1982 1998 5. University of California, CA 1982 1998 6. Acid/Pueblo Canyons, NM 1984 1999 7. Chupadera Mesa, NM 1984 1999 8. Canonsburg, PA 1986 1999 9.Shiprock, NM 1987 2000 10. Middlesex Municipal Landfill, NJ 1987 2000 11. Niagara Falls Storage Site Vicinity Properties, NY 1987 2001 12. Salt Lake City, UT 1989 2001 13. Spook, WY 1989 2001 14. National

  20. US ENC MI Site Consumption

    Annual Energy Outlook

    ... Yes Yes No No 0% 20% 40% 60% 80% 100% US MI No Car CAR IS PARKED WITHIN 20 FT OF ELECTRICAL OUTLET More highlights from RECS on housing characteristics and energy-related ...

  1. MiniBooNE Pion Group

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Contents: Pion Group Home Pion Group Members Pion References Colin's Cross Section Page MiniBooNE Internal Email M. Tzanov....

  2. BooNE: Booster Neutrino Experiment

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Data Releases This page provides MiniBooNE data (histograms, error matrices, ntuples, etc) released in association with particular publications. Only the subset of MiniBooNE papers with released data are listed here. Refer to the Publications page for a complete list of MiniBooNE publications. Other MiniBooNE Data Releases: Data Released with A.A. Aguilar-Arevalo et al., "First Measurement of the Muon Antineutrino Double-Differential Charged-Current Quasielastic Cross section",

  3. BooNE: Booster Neutrino Experiment

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Scrapbook Page 2 The BooNE collaboration in winter. A tour of the construction site. Working with the BooNE Horn. BooNE in the winter A tour of the construction site. A day with the Horn Janet, Bonnie, and Jen in the Tank. Janet and Bill: the early years. Bill, Richard, Jeff, and Shawn in the midst of discussion. Preparing the tubes Janet and Bill: the early days Discussion in progress The oil tanker arrives. The final stages of oil filling. The BooNE Collaboration in the summer. The oil tanker

  4. MiniBooNE Collaboration MiniBooNE Collaboration Yale University

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    MI pulse width Visible Energy Monte Carlo Data cos z (beam direction) Boosted Decision Trees NuMI Event Classification: 1) good dataMC agreement over range of energies 2) Use...

  5. Reservoir fracture mapping using microearthquakes: Austin chalk, Giddings field, TX and 76 field, Clinton Co., KY

    SciTech Connect

    Phillips, W.S.; Rutledge, J.T.; Gardner, T.L.; Fairbanks, T.D.; Miller, M.E.; Schuessler, B.K.

    1996-11-01

    Patterns of microearthquakes detected downhole defined fracture orientation and extent in the Austin chalk, Giddings field, TX and the 76 field, Clinton Co., KY. We collected over 480 and 770 microearthquakes during hydraulic stimulation at two sites in the Austin chalk, and over 3200 during primary production in Clinton Co. Data were of high enough quality that 20%, 31% and 53% of the events could be located, respectively. Reflected waves constrained microearthquakes to the stimulated depths at the base of the Austin chalk. In plan view, microearthquakes defined elongate fracture zones extending from the stimulation wells parallel to the regional fracture trend. However, widths of the stimulated zones differed by a factor of five between the two Austin chalk sites, indicating a large difference in the population of ancillary fractures. Post-stimulation production was much higher from the wider zone. At Clinton Co., microearthquakes defined low-angle, reverse-fault fracture zones above and below a producing zone. Associations with depleted production intervals indicated the mapped fractures had been previously drained. Drilling showed that the fractures currently contain brine. The seismic behavior was consistent with poroelastic models that predicted slight increases in compressive stress above and below the drained volume.

  6. Real-time sub-<mi>>ngstrom...

    Office of Scientific and Technical Information (OSTI)

    Real-time sub-<mi>>ngstrom imaging of reversible and irreversible conformations in rhodium catalysts and graphene Kisielowski, Christian; Wang,...

  7. BooNE: Booster Neutrino Experiment

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Experiment Details This page provides information on the MiniBooNE experiment. Images are linked in their own page with captions. Additional resources are the Talks, Slides and Posters page, Publications page, and Data Release page Beamline Flux Detector Cross sections Light Propagation (Optical Model) Calibration Particle Identification BooNE photo montage

  8. MiniBooNE Results / MicroBooNE Status! Eric Church, Yale University

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    / MicroBooNE Status! Eric Church, Yale University LLWI, 22-Feb-2014 2 G aaah! The US-Canada game is on! right now! (what are we doing at this talk?) 3 Outline  MiniBooNE  past results  future  MicroBooNE  physics motivation  R&D motivation  status: (running is imminent!) 4 The Booster Neutrino Beam BNB p Dirt ~500m Decay region ~50m π + π - ν µ µ - (antineutrino mode) µ Horn polarity flip allows nu or anu modes. 5 MiniBooNE history 6 MiniBooNE  800 tons of

  9. A=16Ne (1982AJ01)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    82AJ01) (See the Isobar Diagram for 16Ne) GENERAL: See also (1977AJ02) and Table 16.27 [Table of Energy Levels] (in PDF or PS). Theoretical work: (1978GU10, 1978SP1C, 1981LI1M). Reviews: (1977CE05, 1979AL1J, 1980TR1E). Mass of 16Ne: The Q-values of the 20Ne(α, 8He) and 16O(π+, π-) reactions lead to an atomic mass excess of 24.02 ± 0.04 MeV for 16Ne. 16Ne is then unbound with respect to decay into 14O + 2p by 1.43 MeV and is bound with respect to decay into 15F + p by 0.04 MeV. 1. 16O(π+,

  10. A=17Ne (1993TI07)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    93TI07) (See the Isobar Diagram for 17Ne) GENERAL: See Table Prev. Table 17.26 preview 17.26 [Table of Energy Levels] (in PDF or PS). 1. (a) 17Ne(β+)17F* → 16O + p Qm = 13.928 (b) 17Ne(β+)17F → 13N + α Qm = 8.711 (c) 17Ne(β+)17F Qm = 14.529 The half-life of 17Ne has been reported as 109.0 ± 1.0 msec (1971HA05) and 109.3 ± 0.6 msec (1988BO39): the weighted mean is 109.2 ± 0.6 and we adopt it. The decay is primarily to the proton unstable states of 17F at 4.65, 5.49, 6.04 and 8.08 MeV

  11. Mi GmbH | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Mi GmbH Jump to: navigation, search Name: Mi GmbH Place: Switzerland Zip: CH-6340 Sector: Solar Product: Baar-based manufacturer and distributor of fruit juices. The firm is also...

  12. 2011 Annual Planning Summary for Nuclear Energy (NE) | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Nuclear Energy (NE) 2011 Annual Planning Summary for Nuclear Energy (NE) The ongoing and projected Environmental Assessments and Environmental Impact Statements for 2011 and 2012 ...

  13. The MicroBooNE Experiment - Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Documents and Publications Public Notes See the Public Notes Page for a list of notes with results made public by the MicroBooNE collaboration. Presentations See the Talks Page for copies of slides and posters presented at conferences and workshops. MicroBooNE Document Database Like most experiments at Fermilab, MicroBooNE uses DocDB - a documents database. Much of the contents of the DocDB are restricted to members of the collaboration, but some items are public. Use the link below to enter the

  14. NE - Nuclear Energy - Energy Conservation Plan

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    NUCLEAR ENERGY (NE) ENERGY CONSERVATION PLAN NE has heavily emphasized the use of flexiplace, both regular and situational. Since approximately 56 percent of NE staff use flexiplace, our plan is based on the Forrestal/Germantown (FORS/GTN) office spaces, and flexiplace office space. There are other common sense actions and policies that will be used to improve energy efficiency in the offices at both FORS and GTN. In the FORS/GTN office space: 1. Use flexiplace to the maximum extent possible.

  15. BooNE: Booster Neutrino Experiment

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Proceedings This page contains links to conference proceedings submitted by members of the MiniBooNE collaboration New Guidelines for Submitting Proceedings at MiniBooNE: As of June 2007, we have changed the rules on conference proceedings. Proceedings must be read by one other MiniBooNE person (besides the author) of postdoc level or above before being submitted. Proceedings should also be sent to boone-talks@fnal.gov for archiving on this website. back to Talks page Speaker Proceedings Info

  16. MiniBooNE Flux Data Release

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    The Neutrino Flux Prediction at MiniBooNE", arXiv:0806.1449 [hep-ex], Phys. Rev. D. 79, 072002 (2009) The following MiniBooNE information from the large flux paper in 2009 is made available to the public: Text files containing flux information for each neutrino species Positive horn polarity (neutrino-enhanced mode) Negative horn polarity (anti neutrino-enhanced mode) Contact Information For clarifications on how to use MiniBooNE public data or for enquiries about additional data not linked

  17. BooNE: Booster Neutrino Experiment

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    in a Nutshell BooNE will investigate the question of neutrino mass by searching for oscillations of muon neutrinos into electron neutrinos. This will be done by directing a muon neutrino beam into the MiniBooNE detector and looking for electron neutrinos. This experiment is motivated by the oscillation results reported by the LSND experiment at Los Alamos. By changing the muon neutrino beam into a muon anti-neutrino beam, BooNE can explore oscillations from muon anti-neutrinos to electron

  18. miRNAs in brain development

    SciTech Connect

    Petri, Rebecca; Malmevik, Josephine; Fasching, Liana; Åkerblom, Malin; Jakobsson, Johan

    2014-02-01

    MicroRNAs (miRNAs) are small, non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. In the brain, a large number of miRNAs are expressed and there is a growing body of evidence demonstrating that miRNAs are essential for brain development and neuronal function. Conditional knockout studies of the core components in the miRNA biogenesis pathway, such as Dicer and DGCR8, have demonstrated a crucial role for miRNAs during the development of the central nervous system. Furthermore, mice deleted for specific miRNAs and miRNA-clusters demonstrate diverse functional roles for different miRNAs during the development of different brain structures. miRNAs have been proposed to regulate cellular functions such as differentiation, proliferation and fate-determination of neural progenitors. In this review we summarise the findings from recent studies that highlight the importance of miRNAs in brain development with a focus on the mouse model. We also discuss the technical limitations of current miRNA studies that still limit our understanding of this family of non-coding RNAs and propose the use of novel and refined technologies that are needed in order to fully determine the impact of specific miRNAs in brain development. - Highlights: • miRNAs are essential for brain development and neuronal function. • KO of Dicer is embryonically lethal. • Conditional Dicer KO results in defective proliferation or increased apoptosis. • KO of individual miRNAs or miRNA families is necessary to determine function.

  19. A=19Ne (1995TI07)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    19.29 (in PDF or PS). The 19Ne decay to 19F*(0.11) J 12+ 12- proceeds by vector and axial vector weak currents, with the former making a negligible contribution. The...

  20. The MicroBooNE Experiment - Collaboration

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Contact MicroBooNE Spokespeople: Bonnie Fleming, Yale email: bonnie.fleming(AT)yale.edu phone: (203) 432-3235 Sam Zeller, FNAL email: gzeller(AT)fnal.gov phone: (630) 840-6879 Collaboration Members

  1. A=16Ne (1986AJ04)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    6AJ04) (See the Isobar Diagram for 16Ne) GENERAL: See also (1982AJ01) and Table 16.26 [Table of Energy Levels] (in PDF or PS) here. See (1981SE1B, 1983ANZQ, 1985AN28, 1985MA1X). Mass of 16Ne: The Q-values of the 20Ne(α, 8He) and 16O(π+, π-) reactions lead to atomic mass excesses of 23.93 ± 0.08 MeV (1978KE06), 23.978 ± 0.024 MeV (1983WO01) and 24.048 ± 0.045 MeV (1980BU15) [recalculated using the (1985WA02) masses for 8He, 16O and 20Ne]. The weighted mean is 23.989 ± 0.020 MeV which is

  2. A=16Ne (1993TI07)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    93TI07) (See the Isobar Diagram for 16Ne) GENERAL: See Table Prev. Table 16.29 preview 16.29 [General Table] (in PDF or PS) and Table Prev. Table 16.32 preview 16.32 [Table of Energy Levels] (in PDF or PS). Mass of 16Ne: The Q-values of the 20Ne(α, 8He) and 16O(π+, π-) reactions lead to atomic mass excesses of 23.93 ± 0.08 MeV (1978KE06), 23.978 ± 0.024 MeV (1983WO01) and 24.048 ± 0.045 MeV (1980BU15) [recalculated using the (1985WA02) masses for 8He, 16O and 20Ne]. The weighted mean is

  3. A=17Ne (1982AJ01)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    82AJ01) (See the Isobar Diagram for 17Ne) GENERAL: See (1977AJ02) and Table 17.22 [Table of Energy Levels] (in PDF or PS). Theory and reviews:(1975BE56, 1977CE05, 1978GU10, 1978WO1E, 1979BE1H). Other topics:(1981GR08). Mass of 17Ne: The mass excess adopted by (1977WA08) is 16.478 ± 0.026 MeV, based on unpublished data. We retain the mass excess 16.48 ± 0.05 MeV based on the evidence reviewed in (1977AJ02). 1. (a) 17Ne(β+)17F* → 16O + p Qm = 13.93 (b) 17Ne(β+)17F Qm = 14.53 The half-life of

  4. A=17Ne (1986AJ04)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    6AJ04) (See the Isobar Diagram for 17Ne) GENERAL: See (1982AJ01) and Table 17.20 [Table of Energy Levels] (in PDF or PS). Theory and reviews: (1983ANZQ, 1983AU1B, 1985AN28). 1. (a) 17Ne(β+)17F* → 16O + p Qm = 13.93 (b) 17Ne(β+)17F Qm = 14.53 The half-life of 17Ne is 109.0 ± 1.0 msec (1971HA05). Earlier values (see (1971AJ02)) gave a mean value of 108.0 ± 2.7 msec. The decay is primarily to the proton unstable states of 17F at 4.70, 5.52 and 6.04 MeV with Jπ = 3/2-, 3/2- and 1/2-: see

  5. A=20Ne (59AJ76)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    59AJ76) (See Energy Level Diagram for 20Ne) GENERAL: See also Table 20.6 [Table of Energy Levels] (in PDF or PS). Theory: See (GA55B, HE55F, MO56, BA57, RA57). 1. 9Be(14N, t)20Ne Qm = 6.323 See (GO58E). 2. 16O(α, γ)20Ne Qm = 4.753 An unsuccessful attempt has been made to observe the isobaric spin-forbidden transition between the T = 0 states at 7.19 MeV (J = 3-) and 1.63 MeV (J = 2+). The radiative width is < 6 x 10-3 eV, indicating an admixture of T = 1 of < 1.3 x 10-3 in 20Ne*(7.19)

  6. UCB-NE-107 user's manual

    SciTech Connect

    Lee, W.W.L.

    1989-03-01

    The purpose of this manual is to provide users of UCB-NE-107 with the information necessary to use UCB-NE-107 effectively. UCB-NE-107 is a computer code for calculating the fractional rate of readily soluble radionuclides that are released from nuclear waste emplaced in water-saturated porous media. Waste placed in such environments will gradually dissolve. For many species such as actinides and rare earths, the process of dissolution is governed by the exterior flow field, and the chemical reaction rate or leaching rate. However, for readily soluble species such as /sup 135/Cs, /sup 137/Cs, and /sup 129/I, it has been observed that their dissolution rates are rapid. UCB-NE-107 is a code for calculating the release rate at the waste/rock interface, to check compliance with the US Nuclear Regulatory Commission's (USNRC) subsystem performance objective. It is an implementation of the analytic solution given below. 5 refs., 2 figs.

  7. The NeXus data format

    SciTech Connect

    Könnecke, Mark; Akeroyd, Frederick A.; Bernstein, Herbert J.; Brewster, Aaron S.; Campbell, Stuart I.; Clausen, Björn; Cottrell, Stephen; Hoffmann, Jens Uwe; Jemian, Pete R.; Männicke, David; Osborn, Raymond; Peterson, Peter F.; Richter, Tobias; Suzuki, Jiro; Watts, Benjamin; Wintersberger, Eugen; Wuttke, Joachim

    2015-01-30

    NeXus is an effort by an international group of scientists to define a common data exchange and archival format for neutron, X-ray and muon experiments. NeXus is built on top of the scientific data format HDF5 and adds domain-specific rules for organizing data within HDF5 files, in addition to a dictionary of well defined domain-specific field names. The NeXus data format has two purposes. First, it defines a format that can serve as a container for all relevant data associated with a beamline. This is a very important use case. Second, it defines standards in the form of application definitions for the exchange of data between applications. NeXus provides structures for raw experimental data as well as for processed data.

  8. BooNE: Booster Neutrino Experiment

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    (numbers, plots, details) of the MiniBooNE experiment and analysis pieces. Images are linked in their own page with captions. Additional resources are the Talks, Slides and...

  9. MiniBooNE Flux Data Release

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    on how to use MiniBooNE public data or for enquiries about additional data not linked from this page, please contact: Steve Brice or Richard Van de Water Acknowledgments If...

  10. BooNE: Booster Neutrino Experiment

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Posters What's a Neutrino? How neutrinos fit into our understanding of the universe. Recipe for a Neutrino Beam Start with some protons... concocting the MiniBooNE beam. The...

  11. The NeXus data format

    DOE PAGES [OSTI]

    Könnecke, Mark; Akeroyd, Frederick A.; Bernstein, Herbert J.; Brewster, Aaron S.; Campbell, Stuart I.; Clausen, Björn; Cottrell, Stephen; Hoffmann, Jens Uwe; Jemian, Pete R.; Männicke, David; et al

    2015-01-30

    NeXus is an effort by an international group of scientists to define a common data exchange and archival format for neutron, X-ray and muon experiments. NeXus is built on top of the scientific data format HDF5 and adds domain-specific rules for organizing data within HDF5 files, in addition to a dictionary of well defined domain-specific field names. The NeXus data format has two purposes. First, it defines a format that can serve as a container for all relevant data associated with a beamline. This is a very important use case. Second, it defines standards in the form of application definitionsmore » for the exchange of data between applications. NeXus provides structures for raw experimental data as well as for processed data.« less

  12. MiniBooNE Nue Data Release

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Neutrino Appearance at the m2 1 eV2 Scale", arXiv:0704.1500 hep-ex, Phys. Rev. Lett. 98, 231801 (2007) The following MiniBooNE information from the first oscillation paper in...

  13. BooNE: Booster Neutrino Experiment

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    elastic cross-section paper is on the archive (arXiv:1309.7257) and has been published in Phys. Rev. D91, 012004 (2015). MiniBooNE's antineutrino charged current quasi-elastic...

  14. MiniBooNE Nuebar Data Release

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Electron Anti-Neutrino Appearance at the m2 1 eV2 Scale", arXiv:0904.1958 hep-ex, Phys. Rev. Lett. 103, 111801 (2009) The following MiniBooNE information from the 2009...

  15. A=20Ne (72AJ02)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ) elastic scattering. It is interpreted in terms of a quasi-molecular -particle cluster model (CO69S). See also (WA65M). 18. 17O(, n)20Ne Qm 0.588 Angular...

  16. MicroBooNE Detector Move

    ScienceCinema

    Flemming, Bonnie; Rameika, Gina

    2014-07-15

    On Monday, June 23, 2014 the MicroBooNE detector -- a 30-ton vessel that will be used to study ghostly particles called neutrinos -- was transported three miles across the Fermilab site and gently lowered into the laboratory's Liquid-Argon Test Facility. This video documents that move, some taken with time-lapse camerad, and shows the process of getting the MicroBooNE detector to its new home.

  17. MicroBooNE Detector Move

    SciTech Connect

    Flemming, Bonnie; Rameika, Gina

    2014-06-25

    On Monday, June 23, 2014 the MicroBooNE detector -- a 30-ton vessel that will be used to study ghostly particles called neutrinos -- was transported three miles across the Fermilab site and gently lowered into the laboratory's Liquid-Argon Test Facility. This video documents that move, some taken with time-lapse camerad, and shows the process of getting the MicroBooNE detector to its new home.

  18. NE Press Releases | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Press Releases NE Press Releases RSS July 6, 2016 Energy Department To Fund Radiochemistry Traineeship Program The Energy Department's offices of Nuclear Energy (NE) and Environmental Management (EM) are co-funding a new traineeship program in radiochemistry at Washington State University (WSU) in Pullman. June 14, 2016 Energy Department Invests $82 Million to Advanced Nuclear Technology In total, 93 projects were selected to receive funding that will help push innovative nuclear technologies

  19. {beta} decay of {sup 26}Ne

    SciTech Connect

    Weissman, L.; Lisetskiy, A.F.; Arndt, O.; Dillmann, I.; Hallmann, O.; Kratz, K.L.; Pfeiffer, B.; Bergmann, U.; Cederkall, J.; Fraile, L.; Koester, U.; Franchoo, S.; Gaudefroy, L.; Sorlin, O.; Tabor, S.

    2004-11-01

    A pure neutron-rich {sup 26}Ne beam was obtained at the ISOLDE facility using isobaric selectivity. This was achieved by a combination of a plasma ion source with a cooled transfer line and subsequent mass separation. The high quality of the beam and good statistics allowed us to obtain new experimental information on the {sup 26}Ne {beta}-decay properties and resolve a contradiction between earlier experimental data and prediction of shell-model calculations.

  20. BooNE: Booster Neutrino Experiment

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Goals of BooNE BooNE's primary goal is to investigate the neutrino oscillation signal reported by the Los Alamos Liquid Scintillator Neutrino Detector (LSND) experiment. In 1995, the LSND collaboration presented strong evidence for the oscillation of muon anti-neutrinos into electron anti-neutrinos. These results led to mass-squared differences around 1 eV2 -- much larger than those observed by atmospheric and solar neutrino oscillation experiments. The LSND measurement remains to be confirmed.

  1. MicroBooNE Detector Stability MICROBOONE-NOTE-1013-PUB The MicroBooNE

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    MicroBooNE Detector Stability MICROBOONE-NOTE-1013-PUB The MicroBooNE Collaboration June 30, 2016 Abstract The Micro Booster Neutrino Experiment (MicroBooNE) is designed to explore the low- energy excess in the ν e event spectrum reported by the MiniBooNE experiment [1] and to measure ν-Ar cross sections in the 1 GeV energy range. The detector is a liquid argon time projection chamber with wire readout, supplemented with a light detection system based on photo-multiplier tubes (PMTs). The

  2. FY17 NE Budget Request Presentation | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    7 NE Budget Request Presentation FY17 NE Budget Request Presentation FY17 NE Budget Request Presentation (2.07 MB) More Documents & Publications FY16 NE Budget Request Presentation Office of Nuclear Energy Fiscal Year 2014 Budget Request Assessment of Small Modular Reactor Suitability for Use On or Near Air Force Space Command Installations SAND 2016-2600

  3. MiniBooNE at All Experimenter's Meeting

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    100807 MiniBooNE Status Report R.G. Van de Water 100107 MiniBooNE Status Report R.G. Van de Water 080607 MiniBooNE Status Report Steve Brice 073007 MiniBooNE Status...

  4. Cross section analyses in MiniBooNE and SciBooNE experiments

    SciTech Connect

    Katori, Teppei

    2015-05-15

    The MiniBooNE experiment (2002-2012) and the SciBooNE experiment (2007-2008) are modern high statistics neutrino experiments, and they developed many new ideas in neutrino cross section analyses. In this note, I discuss selected topics of these analyses.

  5. A=18Ne (1983AJ01)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    83AJ01) (See Energy Level Diagrams for 18Ne) GENERAL: See also (1978AJ03) and Table 18.21 [Table of Energy Levels] (in PDF or PS). Model calculations: (1979DA15, 1979SA31, 1980ZH01). Electromagnetic transitions: (1977HA1Z, 1979SA31, 1982LA26). Special states: (1977HE18, 1978KR1G, 1979DA15, 1979SA31, 1980OK01, 1982ZH1D). Astrophysical questions: (1978WO1E). Complex reactions involving 18Ne: (1979HE1D). Pion-induced capture and reactions (See also reaction 6.): (1977PE12, 1977SP1B, 1978BU09,

  6. A=18Ne (1987AJ02)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    7AJ02) (See Energy Level Diagrams for 18Ne) GENERAL: See (1983AJ01) and Table 18.22 [Table of Energy Levels] (in PDF or PS). Model calculations:(1982ZH01, 1983BR29, 1984SA37, 1985RO1G). Special states:(1982ZH01, 1983BI1C, 1983BR29, 1984SA37, 1985RO1G, 1986AN10, 1986AN07). Electromagnetic transitions:(1982BR24, 1982RI04, 1983BR29, 1985AL21, 1986AN10). Astrophysical questions:(1982WI1B, 1987WI11). Complex reactions involving 18Ne:(1986HA1B). Pion capture and reactions (See also reaction

  7. BooNE: Booster Neutrino Experiment

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Milestones 2008: January 1 1E21 protons on target recorded by MiniBooNE 2007: April 10 25m absorber repaired 2006: August 23 9e16 protons delivered in a single hour (Booster champagne goal) January 18 first antineutrino beam 2004: April 26 Record week (04/19-04/26) 6.83E18 protons delivered. 2003: March 28 Record day: 9.6E17 protons delivered March 18 Record day: 8.18E17 protons delivered March 06 5.5E17 protons delivered to MiniBooNE in 1 hour. (passed the official BD 5E16 milestone) March 01

  8. MicroBooNE First Cosmic Tracks

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    First Tracks in MicroBooNE (August 6, 2015) On August 6, 2015, we started to turn on the drift high voltage in the MicroBooNE detector for the very first time. We paused at 58 kV (this is about 1/2 of our design voltage) and immediately started to see tracks across the entire TPC. Below are some of our first images of cosmic rays and UV laser tracks (last picture) recorded by the TPC! Collection plane images: And here is one of the first images of a UV laser track in the TPC. You can tell which

  9. MiniBooNE Nue Data Release

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Neutrino Appearance at the Δm2 ~1 eV2 Scale", arXiv:0704.1500 [hep-ex], Phys. Rev. Lett. 98, 231801 (2007) The following MiniBooNE information from the first oscillation paper in 2007 is made available to the public: Energy Range for Default Oscillation Fit (475 MeV - 3000 MeV reconstructed neutrino energy) ntuple file of official MiniBooNE sin2(2theta) sensitivity and upper limit curves as a function of Dm2, for a 2-neutrino muon-to-electron oscillation fit, and 90% and 3sigma confidence

  10. MiniBooNE Nuebar Data Release

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Search for Electron Anti-Neutrino Appearance at the Δm2 ~1 eV2 Scale", arXiv:0904.1958 [hep-ex], Phys. Rev. Lett. 103, 111801 (2009) The following MiniBooNE information from the 2009 nuebar appearance paper is made available to the public: Energy Range: 475 MeV - 3000 MeV reconstructed neutrino energy ntuple file of MiniBooNE sin2(2theta) sensitivity and upper limit curves as a function of Dm2, for a 2-neutrino muon-to-electron antineutrino oscillation fit, and 90% and 3sigma confidence

  11. MiniBooNE Oscillation Results

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Oscillation Results and Implications Michael H. Shaevitz for the MiniBooNE Collaboration Abstract. The MiniBooNE Collaboration has reported ...rst results of a search for e appearance in a beam. With two largely independent analyses, no signi...cant excess was observed of events above background for reconstructed neutrino energies above 475 MeV and the data are consistent with no oscillations within a two neutrino appearance-only oscillation model. An excess of events (186 27 33 events) is

  12. MiniBooNE Steve Brice Fermilab

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    17 May 2006 1 MiniBooNE Steve Brice Fermilab * Oscillation Analysis * Issues of the Past Year - Normalization - Optical Model -  0 MisIDs * Summary * Future DOE Review 17 May 2006 2 MiniBooNE Goal * Search for  e appearance in a   beam at the ~0.3% level - L=540 m ~10x LSND - E~500 MeV ~10x LSND DOE Review 17 May 2006 3 Particle ID * Identify electrons (and thus candidate  e events) from characteristic hit topology * Non-neutrino background easily removed     n p W

  13. BooNE: Booster Neutrino Experiment

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    FermiNews A biweekly magazine published by the Fermilab Office of Public Affairs about work and life at Fermilab. 2002: September 20, 2002 - New Neutrino Experiment at Fermilab Goes Live June 14, 2002 - Changing of the Guard: Mike Shaevitz returns to Columbia May 24, 2002 - Beam Me Up: MiniBooNE gets ready to go May 10, 2002 - Dastow 2002: 3D neutrino event simulation Mar. 29, 2002 - Exploring the Invisible Universe Jan. 18, 2002 - A Clear View: MiniBooNE's detector oil 2001: Dec. 14, 2001 -

  14. BooNE: Booster Neutrino Experiment

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Cross Sections MiniBooNE's neutrino flux (with a mean energy of ~700 MeV) dictates the type of neutrino interactions the experiment sees. At these energies, quasi-elastic (QE) and single pion production processes dominate. For MiniBooNE, the contributions from multi-pion production and deep inelastic scattering (DIS) are small. image: neutrino cross sections vs energy There are several cross sections which contribute at these energies. Here is a plot of the charged current (CC) cross section

  15. BooNE: Booster Neutrino Experiment

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Detector The MiniBooNE tank is 12 m diameter sphere, filled with approximately 800 tons of mineral oil, CH2, which has a density of 0.845 ± 0.001 g/cm3. 1280 PMTs provide about 10% coverage of the inner tank region, and 240 PMTs cover the outer, optically isolated "veto" region in the last 1.3 m in the tank. Most of the tubes were recovered from LSND, and are 'old' tubes, some additional ones were bought for MiniBooNE, and are 'new'; differences in the new vs the old tube function are

  16. BooNE: Booster Neutrino Experiment

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Flux The MiniBooNE neutrino flux calculations are described in detail in PRD 79, 072002 (2009) and arXiv:0806.1449 General neutrino fluxes vs true neutrino energy, for MiniBooNE: image:muon neutrino flux image:electron neutrino flux image:final muon and electron neutrino fluxes π+ production Data sets: M.G. Catanesi et al. [HARP Collaboration], ``Measurement of the production cross-section of positive pions in the collision of 8.9-GeV/c protons on beryllium,'', arXiv:hep-ex/0702024 E910

  17. Effect of Structural Stress on the Laser Quality of Highly Doped Yb:KY(WO4)2/KY(WO4)2 and Yb:KLu(WO4)2/KLu(WO4)2 Epitaxial Structures

    SciTech Connect

    Carvajal, J.; Raghothamachar, B; Silvestre, O; Chen, H; Pujol, M; Petrov, V; Dudley, M; Aguilo, M; Diaz, F

    2009-01-01

    In this communication we demonstrate how the difference in laser performance of two highly doped (20 at %) epitaxial layers of Yb-doped KY(WO4)2 (KYW) grown on a KYW substrate and Yb-doped KLu(WO4)2 (KLuW) grown on a KLuW substrate, respectively, is related to the presence of structural stress in the epilayers, investigated by synchrotron white beam X-ray topography. From the results obtained, it is clear that the samples that show a larger amount of structural stress, Yb:KYW/KYW epitaxies, lead to lower efficiency in laser operation, giving a direct correlation between the existence and magnitude of such structural stress and the loss in efficiency of laser performance in such epitaxial layers which, from a spectroscopical point of view, are otherwise equivalent.

  18. F-5 U.S. Energy Information Administration | Annual Energy Outlook...

    Annual Energy Outlook

    Figure F4. Oil and Gas Supply Model Regions Atlantic WA MT WY ID NV UT CO AZ NM TX OK IA KS MO IL IN KY TN MS AL FL GA SC NC WV PA NJ MD DE NY CT ME RI MA NH VA WI MI OH NE...

  19. Luminescent and lasing characteristics of heavily doped Yb{sup 3+}:KY(WO{sub 4}){sub 2} crystals

    SciTech Connect

    Kisel', V E; Troshin, A E; Shcherbitskii, V G; Kuleshov, N V; Pavlyuk, A A; Brunner, F; Paschotta, R; Morier-Genoud, F; Keller, U

    2006-04-30

    The luminescence decay times are measured taking into account reabsorption for KY(WO{sub 4}){sub 2}:Yb(KYW:Yb) crystals with atomic concentrations of active ions from 0.2% to 30%. The radiative lifetime of Yb{sup 3+} ions was measured to be 233 {mu}s. The cw output power of 1.46 and 1.62 W was achieved with the slope efficiency 52% and 47% for Yb:KYW lasers with the atomic concentration of Yb{sup 3+} ions equal to 10% and 30%, respectively. Using a semiconductor mirror with a saturable absorber (SESAM) in the passive mode-locking regime, pulses of duration 194 and 180 fs were obtained at wavelengths of 1042 and 1039 nm for crystals with Yb{sup 3+} concentrations equal to 10% and 30%, respectively, the average output power being 0.63 and 0.75 W. (lasers and amplifiers)

  20. A=16Ne (71AJ02)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    predicts M - A 25.15 0.6 MeV (CE68A: 16Ne is then unbound with respect to breakup into 14O + 2p by 2.6 MeV. See also (GO60K, GO60P, BA61F, GO61N, GO62N, GO62O, GA64A,...

  1. A=16Ne (1977AJ02)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    predicts M - A 25.15 0.6 MeV (1968CE1A); 16Ne is then unbound with respect to breakup into 14O + 2p by 2.6 MeV: see (1971AJ02) for the earlier work. See also (1972WA07)...

  2. UCB-NE-108 user's manual

    SciTech Connect

    Kang, C.H.; Lee, W.W.L.

    1989-04-01

    The purpose of this manual is to provide users of UCB-NE-108 with the information necessary to use UCB-NE-108 effectively. UCB-NE-108 is a computer code for calculating the fractional release rate of readily soluble radionuclides that are released from nuclear waste emplaced in water-saturated porous media, and transported through layers of porous media. Waste placed in such environments will gradually dissolve. For many species such as actinides and rare earths, the process of dissolution is governed by the exterior flow field, and the chemical reaction rate or leaching rate. In a spent-fuel waste package the soluble cesium and iodine accumulated in fuel-cladding gaps, voids, and grain boundaries of spent fuel rods are expected to dissolve rapidly when groundwater penetrates the fuel cladding. UCB-NE-108 is a code for calculating the release rate at the interface of two layers of porous material, such as the backfill around a high-level waste package and natural rock, to check compliance with the US Nuclear Regulatory Commission's (USNRC) subsystem performance objective. It is an implementation of the analytic solution given below. 6 refs., 2 figs.

  3. MiniBooNE Cross Sections

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Sections Group e-mail: BOONE-CROSSSECTIONS(AT)fnal.gov convenors: Alessandro Curioni (alessandro.curioni(AT)yale.edu) and Sam Zeller (gzeller(AT)fnal.gov) Cross Sections at MiniBooNE, Meetings, Reference Articles, Conferences, Useful Links Last updated on 07/19/07

  4. A=17Ne (71AJ02)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Diagram for 17Ne) GENERAL: See also Table 17.22 Table of Energy Levels (in PDF or PS). Theory: (WI64E, MA65J, MA66BB). Reviews: (BA60Q, GO60P, BA61F, GO62N, GO64J, GO66J, GO66L,...

  5. BooNE: Booster Neutrino Experiment

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Civil Construction Pictures The civil construction required for the MiniBooNE experiment consists of two independent construction projects. The Detector Construction: This project was started on October 15, 1999. The 8-GeV Beamline and Target Hall: This project started on June 7, 2000.

  6. A=20Ne (1987AJ02)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    1986VA18, 1986VA23, 1986WE1C, 1987FA09, 1987KO15, 1987NI04, 1987RI03, 1987RO10). Muon and neutrino capture and reactions: (1983RO1E, 1984EL1D, 1984GR03, 1985MI1D,...

  7. DOE - Office of Legacy Management -- Detrex Corp - MI 10

    Office of Legacy Management (LM)

    Detroit , Michigan MI.10-1 Evaluation Year: 1987 MI.10-2 Site Operations: Conducted experimental runs relative to picklingdegreasing of one handful of uranium turnings MI.10-1...

  8. NE-23 List of California Sites NE-23 Hattie Car-well, SAN/NSQA...

    Office of Legacy Management (LM)

    NE-23 Hattie Car-well, SANNSQA Division Attached for your information is the list of California sites we identified in our search of Manhattdn Engineer District records for the ...

  9. MiniBooNE Numu/Numubar Disappearance Data Release

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    for muon neutrino and antineutrino disappearance in MiniBooNE", arXiv:0903.2465 hep-ex, Phys. Rev. Lett. 103, 061802 (2009) The following MiniBooNE information from the 2009 numu...

  10. DOE - Office of Legacy Management -- Adrian - MI 01

    Office of Legacy Management (LM)

    Adrian - MI 01 FUSRAP Considered Sites Adrian, MI Alternate Name(s): Bridgeport Brass Co. Special Metals Extrusion Plant Bridgeport Brass Company General Motors General Motors Company, Adrian MI.01-1 Location: 1450 East Beecher Street, Adrian, Michigan MI.01-3 Historical Operations: Performed uranium extrusion research and development and metal fabrication work for the AEC using uranium, thorium, and plutonium. MI.01-2 Eligibility Determination: Eligible MI.01-1 Radiological Survey(s):

  11. Joint MiniBooNE, SciBooNE Disappearance Analysis Gary Cheng Warren Huelsnitz

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    MiniBooNE, SciBooNE Disappearance Analysis Gary Cheng Warren Huelsnitz Columbia University Los Alamos National Lab Fermilab 31 Aug 2012 Friday, August 31, 2012 Acknowledgements * Teppei Katori * Joe Grange * Zarko Pavlovic * Kendall Mahn and Yasuhiro Nakajima 2 * Muon Neutrino CCQE Cross Section Analysis (Phys. Rev. D81, 092005 (2010)) * Neutrino Contamination in Antineutrino Mode (Phys. Rev. D84, 072005 (2011) and arXiv: 1107.5327) * Electron Neutrino (Antineutrino) Appearance (Phys. Rev. Lett.

  12. DOE - Office of Legacy Management -- Oliver Corp - MI 11

    Office of Legacy Management (LM)

    OLIVER CORP. (MI.11 ) Eliminated from further consideration under FUSRAP - Referred to NRC Designated Name: Not Designated Alternate Name: Behnke Warehousing Incorporated MI.11-1...

  13. The MicroBooNE Technical Design Report

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    MicroBooNE Technical Design Report The MicroBooNE Collaboration 2/24/2012 The MicroBooNE TDR (2/24/2012-DocDB 1821-v12): Table of Contents Page 2 Contents 1 Executive Summary ............................................................................................................................... 8 2 Scientific Objectives ............................................................................................................................ 11 2.1 Overview

  14. U.S. Energy Information Administration | Annual Coal Report 2015

    Energy Information Administration (EIA) (indexed site)

    5. Coal Consumers in the Manufacturing and Coke Sectors, 2015 Company Name Plant Location Top Ten Manufacturers American Crystal Sugar Co MN, ND Archer Daniels Midland IA, IL, MN, NE Carmeuse Lime Stone Inc AL, IN, KY, MI, OH, PA, TN, WI Cemex Inc AL, CA, CO, FL, GA, KY, OH, TN, TX Dakota Gasification Company ND Eastman Chemical Company TN Georgia-Pacific Consumer Products LP AL, GA, OK, WI Holcim (US) Inc AL, CO, MD, MO, MT, OK, SC, TX, UT Mittal Steel USA IN NewPage Corporation MD, MI, WI

  15. The MiniBooNE detector technical design report

    SciTech Connect

    I. Stancu et al.

    2003-04-18

    source. The neutrino beam, produced using 8 GeV protons from the Booster at FNAL, will consist of a target within a focusing system, followed by a {approx}50 m long pion decay volume. The low energy, high intensity and 1 {micro}s time-structure of a neutrino beam produced from the Booster beam are ideal for this experiment. We assume that the Booster can reliably deliver protons for a typical run which is two-thirds of a calendar year. The sensitivities discussed above assume the experiment receives 5 x 10{sup 20} protons per year. This Booster experiment is compatible with the Fermilab collider and MI programs. The Booster must run at 7.5 Hz to accommodate the MiniBooNE and collider programs simultaneously. The current schedule calls for data-taking to begin by the end of calendar year 2001.

  16. A=19Ne (1983AJ01)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    83AJ01) (See Energy Level Diagrams for 19Ne) GENERAL: See (1978AJ03) and Table 19.23 [Table of Energy Levels] (in PDF or PS). Nuclear models: (1978MA2H, 1978PE09, 1978PI06, 1979DA15, 1979MA27, 1979PE16, 1982KI02). Electromagnetic transitions: (1978PE09, 1978SC19, 1979MA27, 1979PE16). Special states: (1978MA2H, 1978PE09, 1978PI06, 1978SC19, 1979DA15, 1980OK01, 1982KI02). Astrophysical questions: (1977SI1D, 1978WO1E, 1979RA1C). Applied topics: (1979AL1Q). Complex reactions involving 19Ne:

  17. A=19Ne (1987AJ02)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    7AJ02) (See Energy Level Diagrams for 19Ne) GENERAL: See (1983AJ01) and Table 19.21 [Table of Energy Levels] (in PDF or PS). Nuclear models:(1983BR29, 1983PO02). Special states: (1983BI1C, 1983BR29, 1983PO02, 1986AN07). Electromagnetic transitions: (1982BR24, 1983BR29, 1985AL21). Astrophysical questions: (1981WA1Q, 1982WI1B, 1986LA07). Applications:(1982BO1N). Complex reactions involving 19Ne:(1981DE1P, 1983JA05, 1984GR08, 1985BE40, 1986GR1A, 1986HA1B, 1987RI03). Pion capture and reactions (See

  18. BooNE: Booster Neutrino Experiment

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Light propagation in mineral oil Though the dominant light observed in MiniBooNE is Cherenkov light, scintillation and fluorescence (here, reabsorbed Cherenkov light re-emitted) account for about 25% of the light. We model: scintillation light (yield, decay times, spectrum), fluorescence, scattering (Rayleigh, Raman), absorption, reflection (off tank walls, PMT faces) and PMT effects (single pe charge response). External measurements Scintillation from p beam (IUCF) Scintillation from cosmic mu

  19. BooNE: Booster Neutrino Experiment

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Particle Identification (PID) We use hit topology and timing to identify events. Particles produce Cherenkov light in our tank, as well as some scintillation light, dependent on particle type. Two independent methods to identify electron neutrinos in MiniBooNE: Boosted Decision Trees, and Track Based. The two methods use different event reconstruction fitters. Boosted Decision Trees (BDT) Decision trees are similar to neural nets, but don't suffer from the same pathologies. To form a decision

  20. Sterile Neutrino Searches in MiniBooNE and MicroBooNE

    SciTech Connect

    Ignarra, Christina M.

    2014-09-01

    Tension among recent short baseline neutrino experiments has pointed toward the possible need for the addition of one or more sterile (non-interacting) neutrino states into the existing neutrino oscillation framework. This thesis first presents the motivation for sterile neutrino models by describing the short-baseline anomalies that can be addressed with them. This is followed by a discussion of the phenomenology of these models. The MiniBooNE experiment and results are then described in detail, particularly the most recent antineutrino analysis. This will be followed by a discussion of global fits to world data, including the anomalous data sets. Lastly, future experiments will be addressed, especially focusing on the MicroBooNE experiment and light collection studies. In particular, understanding the degradation source of TPB, designing the TPB-coated plates for MicroBooNE and developing lightguide collection systems will be discussed. We find an excess of events in the MiniBooNE antineutrino mode results consistent with the LSND anomaly, but one that has a different energy dependence than the low-energy excess reported in neutrino mode. This disagreement creates tension within global fits which include up to three sterile neutrinos. The low-energy excess will be addressed by the MicroBooNE experiment, which is expected to start taking data in early 2015. Tension among existing experiments calls for additional, more decisive future experiments.

  1. The NuMI neutrino beam

    DOE PAGES [OSTI]

    Adamson, P.; Anderson, K.; Andrews, M.; Andrews, R.; Anghel, I.; Augustine, D.; Aurisano, A.; Avvakumov, S.; Ayres, D. S.; Baller, B.; et al

    2015-10-20

    Our paper describes the hardware and operations of the Neutrinos at the Main Injector (NuMI) beam at Fermilab. It elaborates on the design considerations for the beam as a whole and for individual elements. The most important part of our design details pertaining to individual components is described. Beam monitoring systems and procedures, including the tuning and alignment of the beam and NuMI long-term performance, are also discussed.

  2. The NuMI Neutrino Beam

    SciTech Connect

    Adamson, P.; Anderson, K.; Andrews, M.; Andrews, R.; Anghel, I.; Augustine, D.; Aurisano, A.; Avvakumov, S.; Ayres, D. S.; Baller, B.; Barish, B.; Barr, G.; Barrett, W. L.; Berstein, R. H.; Biggs, J.; Bishai, M.; Blake, A.; Bocean, V.; Bock, G. J.; Boehnlein, D. J.; Bogert, D.; Bourkland, K.; Cao, S. V.; Castromonte, C. M.; Childress, S.; Choudhary, B. C.; Coelho, J. A.B.; Cobb, J. H.; Corwin, L.; Crane, D.; Cravens, J. P.; Cronin-Hennessy, D.; Ducar, R. J.; De Jong, J. K.; Devan, A. V.; Devenish, N. E.; Diwan, M. V.; Erwin, A. R.; Escobar, C. O.; Evans, J. J.; Falk, E.; Feldman, G. J.; Fields, T. H.; Ford, R.; Frohne, M. V.; Gallahger, H. R.; Garkusha, V.; Gomes, R. A.; Goodman, M. C.; Gouffon, P.; Graf, N.; Gran, R.; Grossman, N.; Grzelak, K.; Habig, A.; Hahn, S. R.; Harding, D.; Harris, D.; Harris, P. G.; Hartnell, J.; Hatcher, R.; Hays, S.; Heller, K.; Holin, A.; Huang, J.; Hylen, J.; Ibrahim, A.; Indurthy, D.; Irwin, G. M.; Isvan, Z.; Jaffe, D. E.; James, C.; Jensen, D.; Johnstone, J.; Kafka, T.; Kasahara, S. M.S.; Koizumi, G.; Kopp, S.; Kordosky, M.; Kreymer, A.; Lang, K.; Laughton, C.; Lefeuvre, G.; Ling, J.; Litchfield, P. J.; Loiacono, L.; Lucas, P.; Mann, W. A.; Marchionni, A.; Marshak, M. L.; Mayer, N.; McGivern, C.; Medeiros, M. M.; Mehdiyev, R.; Meier, J. R.; Messier, M. D.; Michael, D. G.; Milburn, R. H.; Miller, J. L.; Miller, W. H.; Mishra, S. R.; Sher, S. Moed; Moore, C. D.; Morfin, J.; Mualem, L.; Mufson, S.; Murgia, S.; Murtagh, M.; Musser, J.; Naples, D.; Nelson, J. K.; Newman, H. B.; Nichol, R. J.; Nowak, J. A.; O'connor, J.; Oliver, W. P.; Olsen, M.; Orchanian, M.; Osprey, S.; Pahlka, R. B.; Paley, J.; Para, A.; Patterson, R. B.; Patzak, T.; Pavlovic, Z.; Pawloski, G.; Perch, A.; Peterson, E. A.; Petyt, D. A.; Pfutzner, M. M.; Phan-Budd, S.; Plunkett, R. K.; Poonthottathil, N.; Prieto, P.; Pushka, D.; Qiu, X.; Radovic, A.; Rameika, R. A.; Ratchford, J.; Rebel, B.; Reilly, R.; Rosenfeld, C.; Rubin, H. A.; Ruddick, K.; Sanchez, M. C.; Saoulidou, N.; Sauer, L.; Schneps, J.; Schoo, D.; Schreckenberger, A.; Schreiner, P.; Shanahan, P.; Sharma, R.; Smart, W.; Smith, C.; Sousa, A.; Stefanik, A.; Tagg, N.; Talaga, R. L.; Tassotto, G.; Thomas, J.; Thompson, J.; Thomson, M. A.; Tian, X.; Timmons, A.; Tinsley, D.; Tognini, S. C.; Toner, R.; Torretta, D.; Trostin, I.; Tzanakos, G.; Urheim, J.; Vahle, P.; Vaziri, K.; Villegas, E.; Viren, B.; Vogel, G.; Webber, R. C.; Weber, A.; Webb, R. C.; Wehmann, A.; White, C.; Whitehead, L.; Whitehead, L. H.; Wojcicki, S. G.; Wong-Squires, M. L.; Yang, T.; Yumiceva, F. X.; Zarucheisky, V.; Zwaska, R.

    2015-10-20

    Our paper describes the hardware and operations of the Neutrinos at the Main Injector (NuMI) beam at Fermilab. It elaborates on the design considerations for the beam as a whole and for individual elements. The most important part of our design details pertaining to individual components is described. Beam monitoring systems and procedures, including the tuning and alignment of the beam and NuMI long-term performance, are also discussed.

  3. BooNE: Booster Neutrino Experiment

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Beamline Proton beam 8.89 GeV/c protons from the Fermilab Booster are incident on a beryllium target. The beam is modeled with measured mean position and angle with Gaussian smearing. MiniBooNE simulates the effects of varying the spread in the beam and different focus points of the beam. The typical proton beam contains 4 x 10¹² protons delivered in a spill approximately 1.6 µs in duration. The absolute number of protons on target (p.o.t) is measured by two toroids upstream of the target.

  4. NE NEET-Reactor Materials Award Summaries | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    NE NEET-Reactor Materials Award Summaries NE NEET-Reactor Materials Award Summaries The Nuclear Energy Enabling Technologies Crosscutting Technology Development (NEET- CTD) Reactor Materials Award Summaries describe the research achievements and planned accomplishments for ongoing projects. This Award Summaries document will be updated annually, as needed. NE NEET-Reactor Materials Award Summaries May 2016.pdf (9.42 MB) More Documents & Publications 2016 NEET Advanced Sensors and

  5. Prospects for antineutrino running at MiniBooNE

    SciTech Connect

    Wascko, M.O.; /Louisiana State U.

    2006-02-01

    MiniBooNE began running in antineutrino mode on 19 January, 2006. We describe the sensitivity of MiniBooNE to LSND-like {bar {nu}}{sub e} oscillations and outline a program of antineutrino cross-section measurements necessary for the next generation of neutrino oscillation experiments. We describe three independent methods of constraining wrong-sign (neutrino) backgrounds in an antineutrino beam, and their application to the MiniBooNE antineutrino analyses.

  6. A=19Ne (1959AJ76)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    59AJ76) (See Energy Level Diagram for 19Ne) GENERAL: See also Table 19.9 [Table of Energy Levels] (in PDF or PS). Theory: See (EL55A, RE55, RE55B, RA57, RE58). 1. 19Ne(β+)19F Qm = 3.256 The positron end point is 2.18 ± 0.03 (SC52A), 2.23 ± 0.05 (AL57), 2.24 ± 0.01 MeV (WE58B). The half-life is 17.4 ± 0.2 sec (HE59), 17.7 ± 0.1 (PE57), 18.3 ± 0.5 (AL57), 18.5 ± 0.5 (SC52A), 19 ± 1 (NA54B), 19.5 ± 1.0 (WE58B), 20.3 ± 0.5 sec (WH39). The absence of low-energy γ-rays (see 19F) indicates

  7. FY16 NE Budget Request Presentation | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Presentation (540.09 KB) More Documents & Publications FY17 NE Budget Request Presentation Office of Nuclear Energy Fiscal Year 2014 Budget Request FY 2016 Budget Justification

  8. MiniBooNE darkmatter collaboration

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    MiniBooNE-DM Collaboration A.A. Aguilar-Arevalo,1 B. Batell,2 B.C. Brown,3 R. Carr,4 R. Cooper,5 P. deNiverville,6 R. Dharmapalan,7 R. Ford,3 F.G. Garcia,3 G. T. Garvey,8 J. Grange,9 W. Huelsnitz,8 I. L. de Icaza Astiz,1 R.A. Johnson,10 G. Karagiorgi,4 T. Katori,11 T. Kobilarcik,3 W. Ketchum,8 Q. Liu,8 W.C. Louis,8 C. Mariani,12 W. Marsh,3 D. McKeen,13 C.D. Moore,3 G.B. Mills,8 J. Mirabal,8 P. Nienaber,14 Z. Pavlovic,8 D. Perevalov,3 M. Pospelov,6 H. Ray,9 A. Ritz,6 B.P. Roe,15 M.H. Shaevitz,4

  9. Port Huron, MI Liquefied Natural Gas Exports to Canada (Million...

    Energy Information Administration (EIA) (indexed site)

    Huron, MI Liquefied Natural Gas Exports to Canada (Million Cubic Feet) Port Huron, MI Liquefied Natural Gas Exports to Canada (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul ...

  10. DOE - Office of Legacy Management -- Naval Ordnance Plant - MI...

    Office of Legacy Management (LM)

    Eliminated from further consideration under FUSRAP - Referred to DoD for action Designated ... MI.0-03-1 Site Disposition: Eliminated - No Authority - Referred to DoD MI.0-03-1 ...

  11. miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor

    SciTech Connect

    Park, Jong-Kook; Henry, Jon C.; Jiang, Jinmai; Esau, Christine; Gusev, Yuriy; Lerner, Megan R.; Postier, Russell G.; Brackett, Daniel J.; Schmittgen, Thomas D.

    2011-03-25

    Research highlights: {yields} The expression of miR-132 and miR-212 are significantly increased in pancreatic cancer. {yields} miR-132 and miR-212 target the tumor suppressor pRb, resulting in enhanced proliferation. {yields} miR-132 and miR-212 expression is increased by a {beta}2 adrenergic receptor agonist, suggesting a novel mechanism for pancreatic cancer progression. -- Abstract: Numerous microRNAs (miRNAs) are reported as differentially expressed in cancer, however the consequence of miRNA deregulation in cancer is unknown for many miRNAs. We report that two miRNAs located on chromosome 17p13, miR-132 and miR-212, are over-expressed in pancreatic adenocarcinoma (PDAC) tissues. Both miRNAs are predicted to target the retinoblastoma tumor suppressor, Rb1. Validation of this interaction was confirmed by luciferase reporter assay and western blot in a pancreatic cancer cell line transfected with pre-miR-212 and pre-miR-132 oligos. Cell proliferation was enhanced in Panc-1 cells transfected with pre-miR-132/-212 oligos. Conversely, antisense oligos to miR-132/-212 reduced cell proliferation and caused a G{sub 2}/M cell cycle arrest. The mRNA of a number of E2F transcriptional targets were increased in cells over expressing miR-132/-212. Exposing Panc-1 cells to the {beta}2 adrenergic receptor agonist, terbutaline, increased the miR-132 and miR-212 expression by 2- to 4-fold. We report that over-expression of miR-132 and miR-212 result in reduced pRb protein in pancreatic cancer cells and that the increase in cell proliferation from over-expression of these miRNAs is likely due to increased expression of several E2F target genes. The {beta}2 adrenergic pathway may play an important role in this novel mechanism.

  12. “Nodal Gap” induced by the incommensurate diagonal spin density modulation in underdoped high- <mi>Tmi>c> superconductors

    SciTech Connect

    Zhou, Tao; Gao, Yi; Zhu, Jian -Xin

    2015-03-07

    Recently it was revealed that the whole Fermi surface is fully gapped for several families of underdoped cuprates. The existence of the finite energy gap along the <mi>d>-wave nodal lines (nodal gap) contrasts the common understanding of the <mi>d>-wave pairing symmetry, which challenges the present theories for the high-<mi>Tmi><mi>c>superconductors. Here we propose that the incommensurate diagonal spin-density-wave order can account for the above experimental observation. The Fermi surface and the local density of states are also studied. Our results are in good agreement with many important experiments in high-<mi>Tmi><mi>c>superconductors.

  13. Characterization of function and regulation of miR-24-1 and miR-31

    SciTech Connect

    Sun Fenyong; Wang Jiayi; Pan Qiuhui; Yu Yongchun; Zhang Yue; Wan Yang; Wang Ju; Li Xiaoyan; Hong An

    2009-03-13

    To date, numerous microRNAs (miRNAs) have been discovered. However, the function of these miRNAs is largely unknown. While our knowledge of miRNA post-transcriptional processing has greatly expanded in recent years, we have a limited understanding of the regulation and transcription of miRNA genes. In this study, we characterized two BMP-2 upregulated miRNAs, miR-24-1 and miR-31, in mesenchymal stem cells and showed their opposing function in controlling cellular proliferation, and adipogenesis. Furthermore, we are the first to identify and characterize mouse intronic miR-23b{approx}27b{approx}24-1 and intergenic miR-31 genes. Moreover, we found that pri-miR-23b, pri-miR-27b, and pri-miR-24-1 are transcribed independently and their expression profiles are unique when cells are treated with BMP-2, even though they are located closely together.

  14. An accumulator/compressor ring for Ne+ ions (Conference) | SciTech...

    Office of Scientific and Technical Information (OSTI)

    An accumulatorcompressor ring for Ne+ ions Citation Details In-Document Search Title: An accumulatorcompressor ring for Ne+ ions The primary goal of the High Energy Density ...

  15. New Results from MicroBooNE | Argonne National Laboratory

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    New Results from MicroBooNE November 22, 2016 12:00PM to 1:00PM Presenter Andrew Furmanski, University of Manchester Location Building 362, Room F108 Type Seminar Series HEP Lunch Seminar Abstract: MicroBooNE is a 170t liquid argon time-projection chamber (LArTPC) placed in the booster neutrino beam at Fermilab. Its primary goals are to investigate the low-energy electron-like excess reported by MiniBooNE and to measure neutrino interactions on argon in the 1-GeV energy regime. In addition, it

  16. MiniBooNE Numu/Numubar Disappearance Data Release

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    A Search for muon neutrino and antineutrino disappearance in MiniBooNE", arXiv:0903.2465 [hep-ex], Phys. Rev. Lett. 103, 061802 (2009) The following MiniBooNE information from the 2009 numu and numubar disappearance paper is made available to the public: Numu Disappearance ntuple file of MiniBooNE numu 90% confidence level sensitivity as a function of Dm2, for a 2-neutrino numu -> nux ocillation fit. The file contains 141 rows, with two columns: Dm2 value in the range 0.4 < Dm2 (eV2)

  17. MiniBooNE QE Cross Section Data Release

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Neutrino Charged Current Quasielastic Double Differential Cross section", arXiv:1002:2680 [hep-ex], Phys. Rev. D81, 092005 (2010) The following MiniBooNE information from the 2010 CCQE cross section paper is made available to the public: νμ CCQE cross sections: MiniBooNE flux table of predicted MiniBooNE muon neutrino flux (Table V) flux-integrated double differential cross section (Figure 13) 1D array of bin boundaries partitioning the muon kinetic energy (top) and the cosine of the muon

  18. SAS Output

    Energy Information Administration (EIA) (indexed site)

    5. Coal Consumers in the Manufacturing and Coke Sectors, 2015" "Company Name","Plant Location" "Top Ten Manufacturers" "American Crystal Sugar Co","MN, ND" "Archer Daniels Midland","IA, IL, MN, NE" "Carmeuse Lime Stone Inc","AL, IN, KY, MI, OH, PA, TN, WI" "Cemex Inc","AL, CA, CO, FL, GA, KY, OH, TN, TX" "Dakota Gasification Company","ND" "Eastman Chemical

  19. MicroBooNE Project Critical Decision Documents

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Critical Decisions for MicroBooNE Documents CD-0 Mission Need CD-1 Selection of Alternatives CD-23a Performance Baseline and Long Lead Procurements CD-3b Start of Construction...

  20. {alpha}-cluster states in N{ne}Z nuclei

    SciTech Connect

    Goldberg, V. Z.; Rogachev, G. V.

    2012-10-20

    The importance of studies of {alpha}-Cluster structure in N{ne}Z light nuclei is discussed. Spin-parity assignments for the low-lying levels in {sup 10}C are suggested.

  1. The MicroBooNE Experiment - Getting Started

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... The main protal is the MicroBooNE Homepage. Meetings Document Database Working Group Mailing Lists Collaboration Contact List - if you are new please email andrew.furmanski@manches...

  2. The MicroBooNE Experiment - About the Physics

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Neutrino Beam at Fermilab and produce the first neutrino cross section measurements on argon in the 1 GeV energy range. MicroBooNE will also explore the currently unexplained...

  3. New Oscillation Results From MiniBooNE

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Intrinsic e 20 Background prediction Intrinsic nue External measurements - HARP p+Be for - Sanford-Wang fits to world K + K 0 data MiniBooNE data...

  4. MiniBooNE/LSND Neutrino Oscillation Results

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    M. Sorel (IFIC - CSIC & U. Valencia) Workshop on Beyond Three Family Neutrino Oscillations May 3-4, 2011, LNGS (Italy) 1. LSND e (1993-2001) 2. MiniBooNE ...

  5. MiniBooNE LowE Data Release

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Excess of Electron-Like Events From a 1 GeV Neutrino Beam", arXiv:0812.2243 hep-ex, Phys. Rev. Lett. 102, 101802 (2009) The following MiniBooNE information from the 2009...

  6. The MicroBooNE Project - Home Page

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    posted in the MicroBooNE DocDB, private access user-name is reviewer, password on request. ... Password access to these pages is necessary, user-name is reviewer, password on request. ...

  7. Neutral Current Elastic Interactions in MiniBooNE

    SciTech Connect

    Dharmapalan, Ranjan; /Alabama U.

    2011-10-01

    Neutral Current Elastic (NCE) interactions in MiniBooNE are discussed. In the neutrino mode MiniBooNE reported: the flux averaged NCE differential cross section as a function of four-momentum transferred squared, an axial mass (M{sub A}) measurement, and a measurement of the strange quark spin content of the nucleon, {Delta}s. In the antineutrino mode we present the background-subtracted data which is compared with the Monte Carlo predictions.

  8. MiniBooNE_LoNu_Shaevitz.ppt

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    MiniBooNE MiniBooNE Oscillation Results Oscillation Results and Future and Future Prospects Prospects Mike Mike Shaevitz Shaevitz - Columbia University - Columbia University 6th International Workshop on Low Energy Neutrino Physics 6th International Workshop on Low Energy Neutrino Physics Seoul National University Seoul National University ( ( Nov. 9 - 12, 2011) Nov. 9 - 12, 2011) 2 Neutrino Oscillation Summary Confirmed by K2K and Minos accelerator neutrino exps Confirmed by Kamland reactor

  9. High Precision Measurement of the 19Ne Lifetime

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Precision Measurement of the 19 Ne Lifetime by Leah Jacklyn Broussard Department of Physics Duke University Date: Approved: Albert Young Calvin Howell Kate Scholberg Berndt Mueller John Thomas Dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Physics in the Graduate School of Duke University 2012 Abstract (Nuclear physics) High Precision Measurement of the 19 Ne Lifetime by Leah Jacklyn Broussard Department of Physics

  10. Magnetocrystalline anisotropy in <mi>UMn>2<mi>Ge>2 and related Mn-based actinide ferromagnets

    SciTech Connect

    Parker, David S.; Ghimire, Nirmal; Singleton, John; Thompson, J. D.; Bauer, Eric D.; Baumbach, Ryan; Mandrus, David; Li, Ling; Singh, David J.

    2015-05-04

    We present magnetization isotherms in pulsed magnetic fields up to 62 Tesla, supported by first principles calculations, demonstrating a huge uniaxial magnetocrystalline anisotropy energy - approximately 20 MJ/m3 - in <mi>UMn>2<mi>Ge>2. This large anisotropy results from the extremely strong spin-orbit coupling affecting the uranium 5 f electrons, which in the calculations exhibit a substantial orbital moment exceeding 2 μB. Finally, we also find from theoretical calculations that a number of isostructural Mn-actinide compounds are expected to have similarly large anisotropy.

  11. DOE - Office of Legacy Management -- Star Cutter Corp - MI 15

    Office of Legacy Management (LM)

    Eliminated - Potential for contamination considered remote based on limited scope and quantity of materials handled MI.15-2 Radioactive Materials Handled: Yes Primary ...

  12. MINOS Experiment and NuMI Beam Home Page

    U.S. Department of Energy (DOE) - all webpages

    NuMI-MINOS Neutrino Logo NuMI Beamline and MINOS Experiment Neutrino Logo The MINOS Experiment and NuMI Beamline Fermilab Logo MINOS Experiment Links ◊ MINOS for the Public ◊ Scientific Results ◊ MINOS at Work ◊ NuMI at Work ◊ MINOS+ Experiment Fermilab Neutrino Links ◊ Neutrino FAQ ◊ MINOS Underground Areas at Fermilab ◊ PPD Intensity Frontier Dept Back to - - - ◊ Fermilab at Work ◊ Fermilab Home the MINOS Far Detector in the Soudan Mine MINOS collaborators assembling the

  13. Analysis of natural gases, AL, AR, FL, GA, IL, IN, IA, KY, LA, MD, MI, MS, MO, NJ, NY, NC, OH, PA, TN, VA, and WV; 1951-1991 (for microcomputers). Data file

    SciTech Connect

    Not Available

    1991-01-01

    The U.S. Bureau of Mines diskette contains analysis and related source data for 2,357 natural gas samples collected from miscellaneous states, which include the following states: Alabama, Arkansas (except Arkoma Basin), Florida, Georgia, Illinois, Indiana, Iowa, Kentucky, Louisiana, Maryland, Michigan, Mississippi, Missouri, New Jersey, New York, North Carolina, Ohio, Pennsylvania, Tennessee, Virginia, and West Virginia. All samples were obtained and analyzed as part of the Bureau's investigations of occurrences of helium in natural gases of countries with free market economies. The survey has been conducted since 1917. The analysis contained on the diskette contain the full range of component analysis data. Five files are on the diskette: READ.ME, MISC.TXT, MISC.DBF, USHEANAL.DBF, and BASINCDE.TXT.

  14. The MicroBooNE Experiment - About the Detector

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    the Detector Cryostat delivered Assembly Photos The MicroBooNE time projection chamber (TPC) was assembled at Fermilab in 2012-2013, sealed in the cryostat at the end of 2013, and installed in the Liquid Argon Test Facilty (LArTF) in the Booster neutrino beamline in June 2014. Watch a video of the MicroBooNE detector move! Please check Assembly Photos for a slide-show of the effort These same photos are posted here in a simpler format Photos of Wires Taken from inside the cryostat in April 2015

  15. The MicroBooNE Experiment - At Work

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    MicroBooNE at Work At Work Now The Getting Started Page holds links to help find your way around Fermilab services and prepare for working on the experiment. The MicroBooNE Contact List contains contact information for collaboration members. The Working Groups Page is a portal to these sub-sites. The Operations Page is a portal to the running detector. The Meetings Page lists the current regular meeting time slots, and also lists the collaboration meeting dates with links to the DocDB for past

  16. The MicroBooNE Experiment - Conference Talks

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Talks and Posters Once you have given a MicroBooNE presentation, please send your talk to Sam Zeller so it can be archived. If you have written proceedings to accompany your talk, please upload them to the MicroBooNE DocDB and send the document number to Sam. Also, remember that conference proceedings are required by Fermilab policy to be submitted to the Fermilab Technical Publications archive. Instructions for doing that are here. Click here for Future talks. Conference Presentations Speaker

  17. The MicroBooNE Experiment - Public Notes

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Public Notes Page Back to the Publications Page 7/4/16 MICROBOONE-NOTE-1019-PUB Convolutional Neural Networks Applied to Neutrino Events in a Liquid Argon Time Projection Chamber 7/4/16 MICROBOONE-NOTE-1017-PUB A Method to Extract the Charge Distribution Arriving at the TPC Wire Planes in MicroBooNE 7/4/16 MICROBOONE-NOTE-1016-PUB Noise Characterization and Filtering in the MicroBooNE TPC 7/4/16 MICROBOONE-NOTE-1015-PUB The Pandora multi-algorithm approach to automated pattern recognition in LAr

  18. MiniBooNE Antineutrino Data Van Nguyen Columbia University

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Moriond EW 2008 Coherent NC π 0 Production in the MiniBooNE Antineutrino Data Van Nguyen Columbia University for the MiniBooNE collaboration Moriond EW 2008 2 Moriond EW 2008 At low energy, NC π 0 's can be created through resonant and coherent production:  Resonant NC π 0 production:  Coherent NC π 0 production: (Signature: π 0 which is highly forward-going) NC π 0 Production 3 Moriond EW 2008 Why study coherent NC π 0 production? ➔ NC π 0 events are the dominant bgd to osc

  19. Exclusive Neutrino Cross Sections From MiniBooNE

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Exclusive Neutrino Cross Sections From MiniBooNE Martin Tzanov University of Colorado PANIC 2008, 9-14 November, Eilat, ISRAEL Martin Tzanov, PANIC 2008 Neutrino Cross Sections Today * Precise knowledge needed for precise oscillation measurements. * Cross section well measured above 20 GeV. * Few measurements below 20 GeV. * 20-30 years old bubble chamber experiments (mostly H 2 , D 2 ). * Neutral current cross sections are even less understood. ν CC world data CC world data ν T2K, BooNE K2K,

  20. SHORT-BASELINE NEUTRINO PHYSICS AT MiniBooNE E. D. Zimmerman

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    NEUTRINO PHYSICS AT MiniBooNE E. D. Zimmerman University of Colorado PANIC 2011 Cambridge, Mass. 25 July 2011 Short-Baseline Neutrino Physics at MiniBooNE * MiniBooNE * Neutrino cross-sections * Hadron production channels * Oscillation physics * Antineutrino Oscillations * MiniBooNE-SciBooNE joint result Motivating MiniBooNE: LSND Liquid Scintillator Neutrino Detector * Stopped + beam at Los Alamos LAMPF produces e , , ̅ but no ̅ e (due to capture). * Look for delayed coincidence of positron

  1. Appearance Results from MiniBooNE Georgia Karagiorgi Columbia University

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Appearance Results from MiniBooNE Georgia Karagiorgi Columbia University WIN'11 - Cape Town, South Africa 2 Outline of this talk: -- The LSND excess signal: Evidence for high-Δm 2 oscillations -- The MiniBooNE experiment -- MiniBooNE neutrino mode oscillation results: LSND signature refuted -- MiniBooNE antineutrino mode oscillation results: LSND signature confrmed ? -- Light sterile neutrino oscillations: Where we stand today -- Future searches: MiniBooNE, MicroBooNE 1993 -1998 1998 2001

  2. Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells

    SciTech Connect

    Vrba, Lukas; Jensen, Taylor J.; Garbe, James C.; Heimark, Ronald L.; Cress, Anne E.; Dickinson, Sally; Stampfer, Martha R.; Futscher, Bernard W.

    2009-12-23

    BACKGROUND: The microRNA-200 family participates in the maintenance of an epithelial phenotype and loss of its expression can result in epithelial to mesenchymal transition (EMT). Furthermore, the loss of expression of miR-200 family members is linked to an aggressive cancer phenotype. Regulation of the miR-200 family expression in normal and cancer cells is not fully understood. METHODOLOGY/ PRINCIPAL FINDINGS: Epigenetic mechanisms participate in the control of miR-200c and miR-141 expression in both normal and cancer cells. A CpG island near the predicted mir-200c/mir-141 transcription start site shows a striking correlation between miR-200c and miR-141 expression and DNA methylation in both normal and cancer cells, as determined by MassARRAY technology. The CpG island is unmethylated in human miR-200/miR-141 expressing epithelial cells and in miR-200c/miR-141 positive tumor cells. The CpG island is heavily methylated in human miR-200c/miR-141 negative fibroblasts and miR-200c/miR-141 negative tumor cells. Mouse cells show a similar inverse correlation between DNA methylation and miR-200c expression. Enrichment of permissive histone modifications, H3 acetylation and H3K4 trimethylation, is seen in normal miR-200c/miR-141-positive epithelial cells, as determined by chromatin immunoprecipitation coupled to real-time PCR. In contrast, repressive H3K9 dimethylation marks are present in normal miR-200c/miR-141-negative fibroblasts and miR-200c/miR-141 negative cancer cells and the permissive histone modifications are absent. The epigenetic modifier drug, 5-aza-2'-deoxycytidine, reactivates miR-200c/miR-141 expression showing that epigenetic mechanisms play a functional role in their transcriptional control. CONCLUSIONS/ SIGNIFICANCE: We report that DNA methylation plays a role in the normal cell type-specific expression of miR-200c and miR-141 and this role appears evolutionarily conserved, since similar results were obtained in mouse. Aberrant DNA methylation of the

  3. DOE-NE Small Business Voucher Program Launched

    Energy.gov [DOE]

    As part of the Gateway for Accelerated Innovation in Nuclear (GAIN) initiative, the NE Voucher program will provide up to $2 million in this pilot year for access to expertise, knowledge, and facilities of the National Laboratories and our partner facilities to help advance nuclear energy technologies.

  4. Nu2010_MiniBooNE_Osc.pptx

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... Most importantly, not a region of LE where LSND observed a significant signal Energy in MiniBooNE MeV 1250 475 333 MB Neutrino mode LE (mMeV) "LSND sweet spot" LSND * 6.5E20 ...

  5. Neutral Current Elastic Interactions at MiniBooNE

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... with the shape-only fits from MiniBooNE CCQE data mode results: 2. Axial vector mass (M A ): 10 3. Strange quark spin (s) : Above 350 MeV Assuming M A 1.35 GeV for ...

  6. Precision angle-resolved autoionization resonances in Ar and Ne

    SciTech Connect

    Berrah, N.; Langer, B.; Gorczyca, T.W.

    1997-04-01

    Theoretical work has shown that the electron angular distribution and the shape of the autoionization resonances are crucial to the understanding of certain types of electron-electron correlation. Autoionization resonances in Ne (Ar) result from the decay of the excited discrete state Ne{sup *} 2s2p{sup 6} np (Ar{sup *} 3s3p{sup 6} np) into the continuum state Ne{sup +} 2s{sup 2}2p{sup 5} + e{sup {minus}} (ks,kd) (Ar{sup +} 3s{sup 2}3p{sup 5} + e{sup {minus}} (ks,kd)). Since the continuum can also be reached by direct photoionization, both paths add coherently, giving rise to interferences that produce the characteristic Beutler-Fano line shape. In this work, the authors report on quantitative angle-resolved electron spectrometry studies of (a) the Ne 2s{sup 2}2p{sup 6} {r_arrow} 2s2p{sup 6} np (n=3-5) autoionizing resonances and the 2s{sup 2}2p{sup 6} {r_arrow} 2p{sup 4}3s3p doubly excited resonance, (b) the Ar 3s{sup 2}3p{sup 6} {r_arrow} 3s3p{sup 6} np (n=4-9) autoionization resonances and extended R-matrix calculations of the angular-distribution parameters for both Ne and Ar measurements. Their results are compared with previous theoretical work by Taylor.

  7. Kentucky Department for Natural Resources and Environmental Protection permit application for air contaminant source: SRC-I demonstration plant, Newman, Kentucky. Supplement I. [Additional information on 38 items requested by KY/DNREP

    SciTech Connect

    Pearson, Jr., John F.

    1981-02-13

    In response to a letter from KY/DNREP, January 19, 1981, ICRC and DOE have prepared the enclosed supplement to the Kentucky Department for Natural Resources and Environmental Protection Permit Application for Air Contaminant Source for the SRC-I Demonstration Plant. Each of the 38 comments contained in the letter has been addressed in accordance with the discussions held in Frankfort on January 28, 1981, among representatives of KY/DNREP, EPA Region IV, US DOE, and ICRC. The questions raised involve requests for detailed information on the performance and reliability of proprietary equipment, back-up methods, monitoring plans for various pollutants, composition of wastes to flares, emissions estimates from particular operations, origin of baseline information, mathematical models, storage tanks, dusts, etc. (LTN)

  8. ReNeW: Magnetic Fusion Energy Research Needs for the ITER Era...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ReNeW: Magnetic Fusion Energy Research Needs for the ITER Era Citation Details In-Document Search Title: ReNeW: Magnetic Fusion Energy Research Needs for the ITER Era Authors: ...

  9. Oscillations results from the MiniBooNE experiment Alexis Aguilar...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    (ICN-UNAM) SILAFAE 2010, Valparaso, Chile December 6-12, 2010 Input from HARP production data 10 and interactions MiniBooNE MiniBooNE CCQE (MB...

  10. NE & EERE Working Together: 5 Facts About the New Energy Innovation...

    Energy Saver

    NE & EERE Working Together: 5 Facts About the New Energy Innovation Lab at Idaho National Laboratory NE & EERE Working Together: 5 Facts About the New Energy Innovation Lab at ...

  11. DOE-NE Light Water Reactor Sustainability Program and EPRI Long...

    Energy Saver

    2-24562 Revision 4 DOE-NE Light Water Reactor Sustainability Program and EPRI Long Term ... INLEXT-12-24562 Revision 4 DOE-NE Light Water Reactor Sustainability Program and EPRI ...

  12. miR-92a family and their target genes in tumorigenesis and metastasis

    SciTech Connect

    Li, Molin; Guan, Xingfang; Sun, Yuqiang; Mi, Jun; Shu, Xiaohong; Liu, Fang; Li, Chuangang

    2014-04-15

    The miR-92a family, including miR-25, miR-92a-1, miR-92a-2 and miR-363, arises from three different paralog clusters miR-17-92, miR-106a-363, and miR-106b-25 that are highly conservative in the process of evolution, and it was thought as a group of microRNAs (miRNAs) correlated with endothelial cells. Aberrant expression of miR-92a family was detected in multiple cancers, and the disturbance of miR-92a family was related with tumorigenesis and tumor development. In this review, the progress on the relationship between miR-92a family and their target genes and malignant tumors will be summarized. - Highlights: • Aberrant expression of miR-92a, miR-25 and miR-363 can be observed in many kinds of malignant tumors. • The expression of miR-92a family is regulated by LOH, epigenetic alteration, transcriptional factors such as SP1, MYC, E2F, wild-type p53 etc. • Roles of miR-92a family in tumorigenesis and development: promoting cell proliferation, invasion and metastasis, inhibiting cell apoptosis.

  13. Application for Presidential Permit OE Docket No. PP-400 TDI- NE New

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    England Clean Power Link Project | Department of Energy NE New England Clean Power Link Project Application for Presidential Permit OE Docket No. PP-400 TDI- NE New England Clean Power Link Project Response to TDI - NE application from State Department to construct, operate, and maintain electric transmission facilities at the U.S. - Canada Border. State Department Concurrence.pdf (42.84 KB) More Documents & Publications Application for Presidential Permit OE Docket No. PP-400 TDI-NE

  14. RESULTS OF THE MiniBooNE NEUTRINO OSCILLATION SEARCH E. D. Zimmerman

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    RESULTS OF THE MiniBooNE NEUTRINO OSCILLATION SEARCH E. D. Zimmerman University of Colorado American Physical Society Meeting Jacksonville, April 16, 2007 Results of the MiniBooNE Neutrino Oscillation Search * Introduction to MiniBooNE * The oscillation analysis * The initial results and their implications * The next steps MiniBooNE: E898 at Fermilab * Purpose is to test LSND with: * Higher energy * Different beam * Different oscillation signature * Different systematics * L=500 meters, E=0.5-1

  15. Role of the N*(1535) resonance and the {pi}{sup -}p{yields}KY amplitudes in the OZI forbidden {pi}N{yields}{phi}N reaction

    SciTech Connect

    Doering, M.; Oset, E.; Zou, B. S.

    2008-08-15

    We study the {pi}N{yields}{phi}N reaction close to the {phi}N threshold within the chiral unitary approach, by combining the {pi}{sup -}p{yields}K{sup +}{sigma}{sup -},{pi}{sup -}p{yields}K{sup 0}{sigma}{sup 0}, and {pi}{sup -}p{yields}K{sup 0}{lambda} amplitudes with the coupling of {phi} to the K components of the final states of these reactions via quantum loops. We obtain good agreement with experiment when the dominant {pi}{sup -}p{yields}K{sup 0}{lambda} amplitude is constrained with its experimental cross section. We also evaluate the coupling of N*(1535) to {phi}N and find a moderate coupling as a consequence of partial cancellation of the large KY components of N*(1535). We also show that the N*(1535) pole approximation is too small to reproduce the measured cross section for the {pi}{sup -}N{yields}{phi}N reaction.

  16. Overview of DOE-NE Proliferation and Terrorism Risk Assessment

    SciTech Connect

    Sadasivan, Pratap

    2012-08-24

    Research objectives are: (1) Develop technologies and other solutions that can improve the reliability, sustain the safety, and extend the life of current reactors; (2) Develop improvements in the affordability of new reactors to enable nuclear energy; (3) Develop Sustainable Nuclear Fuel Cycles; and (4) Understand and minimize the risks of nuclear proliferation and terrorism. The goal is to enable the use of risk information to inform NE R&D program planning. The PTRA program supports DOE-NE's goal of using risk information to inform R&D program planning. The FY12 PTRA program is focused on terrorism risk. The program includes a mix of innovative methods that support the general practice of risk assessments, and selected applications.

  17. Port Huron, MI Natural Gas Pipeline Imports From Canada (Million...

    Energy Information Administration (EIA) (indexed site)

    Million Cubic Feet) Port Huron, MI Natural Gas Pipeline Imports From Canada (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2016 262 - No Data Reported; ...

  18. PNM Resources 2401 Aztec NE, MS-Z100

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    PNM Resources 2401 Aztec NE, MS-Z100 Albuquerque, NM 87107 505-241-2025 Fax 505 241-2384 PNMResources.com October 29, 2013 Mr. Christopher Lawrence Office of Electricity Delivery and Energy Reliability (OE-20) U.S. Department of Energy 1000 Independence Avenue, SW Washington, DC 20585 Submitted electronically via email to: Christopher.Lawrence@hq.doe.gov Dear Mr. Lawrence: Subject: Department of Energy (DOE)- Improving Performance of Federal Permitting and Review of Infrastructure Projects,

  19. miR-107 and miR-25 simultaneously target LATS2 and regulate proliferation and invasion of gastric adenocarcinoma (GAC) cells

    SciTech Connect

    Zhang, Mingjun; Wang, Xiaolei; Li, Wanhu; Cui, Yongchun

    2015-05-08

    Although a series of oncogenes and tumor suppressors were identified in the pathological development of gastric adenocarcinoma (GAC), the underlying molecule mechanism were still not fully understood. The current study explored the expression profile of miR-107 and miR-25 in GAC patients and their downstream regulative network. qRT-PCR analysis was performed to quantify the expression of these two miRNAs in serum samples from both patients and healthy controls. Dual luciferase assay was conducted to verify their putative bindings with LATS2. MTT assay, cell cycle assay and transwell assay were performed to explore how miR-107 and miR-25 regulate proliferation and invasion of gastric cancer cells. Findings of this study demonstrated that total miR-107 or miR-25 expression might be overexpressed in gastric cancer patients and they can simultaneously and synchronically regulate LATS2 expression, thereby affecting gastric cancer cell growth and invasion. Therefore, the miR-25/miR-107-LATS2 axis might play an important role in proliferation and invasion of the gastric cancer cells. - Highlights: • Total miR-107 and miR-25 expression is significantly increased in GAC patients. • Both miR-107 and miR-25 can promote proliferation and invasion of GAC cells. • Both miR-107 and miR-25 can target LATS2 and regulate its expression. • miR-107 and miR-25 regulate proliferation and invasion of GAC cells though LATS2.

  20. miR-17 inhibitor suppressed osteosarcoma tumor growth and metastasis via increasing PTEN expression

    SciTech Connect

    Gao, Yong; Luo, Ling-hui; Li, Shuai; Yang, Cao

    2014-02-07

    Highlights: • miR-17 was increased in OS tissues and cell lines. • Inhibition of miR-17 suppressed OS cell proliferation. • Inhibition of miR-17 suppressed OS cell migration and invasion. • PTEN was a target of miR-17. • miR-17 was negatively correlated with PTEN in OS tissues. - Abstract: MicroRNAs (miRNAs) play essential roles in cancer development and progression. Here, we investigated the role of miR-17 in the progression and metastasis of osteosarcoma (OS). miR-17 was frequently increased in OS tissues and cell lines. Inhibition of miR-17 in OS cell lines substantially suppressed cell proliferation, migration, and invasion. Phosphatase and tensin homolog (PTEN) was identified as a target of miR-17, and ectopic expression of miR-17 inhibited PTEN by direct binding to its 3′-untranslated region (3′-UTR). Expression of miR-17 was negatively correlated with PTEN in OS tissues. Together, these findings indicate that miR-17 acts as an oncogenic miRNA and may contribute to the progression and metastasis of OS, suggesting miR-17 as a potential novel diagnostic and therapeutic target of OS.

  1. Migration of Nuclear Shell Gaps Studied in the d({sup 24}Ne,p{gamma}){sup 25}Ne Reaction

    SciTech Connect

    Catford, W. N.; Timis, C. N.; Baldwin, T. D.; Gelletly, W.; Pain, S. D.; Lemmon, R. C.; Pucknell, V. P. E.; Warner, D. D.; Labiche, M.; Orr, N. A.; Achouri, N. L.; Chapman, R.; Amzal, N.; Burns, M.; Liang, X.; Spohr, K.; Freer, M.; Ashwood, N. I.

    2010-05-14

    The transfer of neutrons onto {sup 24}Ne has been measured using a reaccelerated radioactive beam of {sup 24}Ne to study the (d,p) reaction in inverse kinematics. The unusual raising of the first 3/2{sup +} level in {sup 25}Ne and its significance in terms of the migration of the neutron magic number from N=20 to N=16 is put on a firm footing by confirmation of this state's identity. The raised 3/2{sup +} level is observed simultaneously with the intruder negative parity 7/2{sup -} and 3/2{sup -} levels, providing evidence for the reduction in the N=20 gap. The coincident gamma-ray decays allowed the assignment of spins as well as the transferred orbital angular momentum. The excitation energy of the 3/2{sup +} state shows that the established USD shell model breaks down well within the sd model space and requires a revised treatment of the proton-neutron monopole interaction.

  2. Figure F7. Coal supply regions

    Gasoline and Diesel Fuel Update

    8 Appendix F Figure F7. Coal supply regions WA ID OR CA NV UT TX OK AR MO LA MS AL GA FL TN SC NC KY VA WV WY CO SD ND MI MN WI IL IN OH MD PA NJ DE CT MA NH VT NY ME RI MT NE IA KS MI AZ NM 500 0 SCALE IN MILES APPALACHIA Northern Appalachia Central Appalachia Southern Appalachia INTERIOR NORTHERN GREAT PLAINS Eastern Interior Western Interior Gulf Lignite Dakota Lignite Western Montana Wyoming, Northern Powder River Basin Wyoming, Southern Powder River Basin Western Wyoming OTHER WEST Rocky

  3. MiR-218 Mediates tumorigenesis and metastasis: Perspectives and implications

    SciTech Connect

    Lu, Ying-fei; Zhang, Li; Waye, Mary Miu Yee; Fu, Wei-ming; Zhang, Jin-fang

    2015-05-15

    MicroRNAs (miRNAs) are a class of small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. As a highly conserved miRNA across a variety of species, microRNA-218 (miR-218) was found to play pivotal roles in tumorigenesis and progression. A group of evidence has demonstrated that miR-218 acts as a tumor suppressor by targeting many oncogenes related to proliferation, apoptosis and invasion. In this review, we provide a complex overview of miR-218, including its regulatory mechanisms, known functions in cancer and future challenges as a potential therapeutic target in human cancers. - Highlights: • miR-218 is frequently down regulated in multiple cancers. • miR-218 plays pivotal roles in carcinogenesis. • miR-218 mediates proliferation, apoptosis, metastasis, invasion, etc. • miR-218 mediates tumorigenesis and metastasis via multiple pathways.

  4. NE-24 Unlverslty of Chicayo Remedial Action Plan

    Office of Legacy Management (LM)

    c,(YJ 4 tlsj .?I2 416 17 1983 NE-24 Unlverslty of Chicayo Remedial Action Plan 22&d 7 IA +-- E. I.. Keller, Director Technical Services Division Oak Ridge Operations Ufflce In response to your memorandum dated July 29, 1983, the Field Task Proposal/Agreement (FTP/A) received frw Aryonne National Laboratory (ANL) appears to be satisfactory, and this office concurs in the use of ANL to provide the decontamination effort as noted in the FTP/A. The final decontaminatton report should Include the

  5. 2016 ANNUAL DOE-NE MATERIALS RESEARCH MEETING

    Office of Energy Efficiency and Renewable Energy (EERE)

    The Reactor Materials element of the Nuclear Energy Enabling Technologies (NEET) program conducted its FY 2016 coordination meeting as a series of two web-conferences to act as a forum for the nuclear materials research community. The purpose of this meeting was to report on current and planned nuclear materials research, identify new areas of collaboration and promote greater coordination among the various Office of Nuclear Energy (NE) programs. Although each program has unique materials issues, there are opportunities to enhance coordination and collaboration. The presentations from this two part webinar series are available here.

  6. MiniBooNE LowE Data Release

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Unexplained Excess of Electron-Like Events From a 1 GeV Neutrino Beam", arXiv:0812.2243 [hep-ex], Phys. Rev. Lett. 102, 101802 (2009) The following MiniBooNE information from the 2009 updated nue oscillation paper is made available to the public: Energy Range for Default Oscillation Fit (475 MeV - 3000 MeV reconstructed neutrino energy) 1D array of bin boundaries in electron neutrino reconstructed neutrino energy 1D array of observed electron neutrino candidate events per reconstructed

  7. Idaho National Laboratory DOE-NE's National Nuclear Capability-

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    -2023 Idaho National Laboratory DOE-NE's National Nuclear Capability- Developing and Maintaining the INL Infrastructure TEN-YEAR SITE PLAN DOE/ID-11474 Final June 2012 Sustainable INL continues to exceed DOE goals for reduction in the use of petroleum fuels - running its entire bus fleet on biodiesel while converting 75% of its light-duty fleet to E85 fuel. The Energy Systems Laboratory (ESL), slated for completion this year, will be a state-of-the-art laboratory with high-bay lab space where

  8. Exclusive Neutrino Cross Sections From MiniBooNE

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    5[BOPW -PVJTJBOB 4UBUF 6OJWFSTJUZ /V'BDU 8PSLTIPQ 8JMMJBNTCVSH +VMZ -BUFTU $SPTT 4FDUJPO 3FTVMUT GSPN .JOJ#PP/& Test of LSND within the context of e appearance only is an essential first step: Keep the same L/E w )JHIFS FOFSHZ BOE MPOHFS CBTFMJOF r & r (F7 L=500m w %JGGFSFOU CFBN w %JGGFSFOU PTDJMMBUJPO TJHOBUVSF F w %JGGFSFOU TZTUFNBUJDT w "OUJOFVUSJOP DBQBCMF CFBN MiniBooNE Experiment ± E898 at Fermilab Booster K + target and horn detector dirt decay region absorber primary beam

  9. Office of Nuclear Energy Doe/ne-0143

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    energy Office of Nuclear Energy Doe/ne-0143 Table of Contents Lesson 1 - Energy Basics Lesson 2 - Electricity Basics Lesson 3 - Atoms and Isotopes Lesson 4 - Ionizing Radiation Lesson 5 - Fission, Chain Reactions Lesson 6 - Atom to Electricity Lesson 7 - Waste from Nuclear Power Plants Lesson 8 - Concerns Lesson 9 - Energy and You 1 Lesson 1 Energy Basics ENERGY BASICS What is energy? Energy is the ability to do work. But what does that really mean? You might think of work as cleaning your room,

  10. The MicroBooNE Experiment - About the Detector

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Detector Assembly MicroBooNE Assembly Photos Please click here if you prefer a simple page of photos. Assembly of the TPC began at Fermilab during the summer of 2012. Everyone is pitching in from summer students to scientists. Check back regularly for updated photos. Moving a dewar One of two dewars being moved to LArTF. One will be used for liquid nitrogen and the other will be an argon buffer tank. LArTF First Floor This is the ground floor of the new Liquid Argon Test Facility (LArTF). (Photo

  11. The MicroBooNE Experiment - About the Detector

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Detector Assembly MicroBooNE Assembly Photos Assembly of the TPC began at Fermilab during the summer of 2012. Everyone is pitching in from summer students to scientists. Check back regularly for updated photos. Moving a dewar One of two dewars being moved to LArTF. One will be used for liquid nitrogen and the other will be an argon buffer tank. LArTF First Floor This is the ground floor of the new Liquid Argon Test Facility (LArTF). (Photo from Fermilab VMS) LArFT First Floor First floor

  12. NuMI Low Energy Flux Prediction Release

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    NuMI Low Energy Flux Prediction Release Neutrino Flux Predictions for the NuMI Beam hep-ex/1607.00704 Data Ancillary data files for this result are available on arXiv at http://arxiv.org/src/1607.00704/anc Among the available data files are: pdf file describing format of all the available files root file of all the available fluxes python code to read and process MINERvA's flux predictions Text Files of the flux, uncertainties, and covariance matrix, with units of neutrinos/m^2/POT, in 0.5 GeV

  13. miRNA-205 affects infiltration and metastasis of breast cancer

    SciTech Connect

    Wang, Zhouquan; Department of Tumor, SenGong Hospital of Shaanxi, Xian 710300 ; Liao, Hehe; Deng, Zhiping; Yang, Po; Du, Ning; Zhanng, Yunfeng; Ren, Hong

    2013-11-08

    Highlights: We detected expression of miR-205 in breast cancer cell lines and tissue samples. We suggest miR-205 is downregulated in human breast cancer tissues and MCF7 cells. We suggest the lower expression of miR-205 play a role in breast cancer onset. These data suggest that miR-205 directly targets HER3 in human breast cancer. -- Abstract: Background: An increasing number of studies have shown that miRNAs are commonly deregulated in human malignancies, but little is known about the function of miRNA-205 (miR-205) in human breast cancer. The present study investigated the influence of miR-205 on breast cancer malignancy. Methods: The expression level of miR-205 in the MCF7 breast cancer cell line was determined by quantitative (q)RT-PCR. We then analyzed the expression of miR-205 in breast cancer and paired non-tumor tissues. Finally, the roles of miR-205 in regulating tumor proliferation, apoptosis, migration, and target gene expression were studied by MTT assay, flow cytometry, qRT-PCR, Western blotting and luciferase assay. Results: miR-205 was downregulated in breast cancer cells or tissues compared with normal breast cell lines or non-tumor tissues. Overexpression of miR-205 reduced the growth and colony-formation capacity of MCF7 cells by inducing apoptosis. Overexpression of miR-205 inhibited MCF7 cell migration and invasiveness. By bioinformation analysis, miR-205 was predicted to bind to the 3? untranslated regions of human epidermal growth factor receptor (HER)3 mRNA, and upregulation of miR-205 reduced HER3 protein expression. Conclusion: miR-205 is a tumor suppressor in human breast cancer by post-transcriptional inhibition of HER3 expression.

  14. High-energy physics detector MicroBooNE sees first accelerator-born

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    neutrinos MicroBooNE sees first accelerator-born neutrinos High-energy physics detector MicroBooNE sees first accelerator-born neutrinos The principal purpose of the detector is to confirm or deny the existence of a hypothetical particle known as the sterile neutrino. November 2, 2015 An accelerator-born neutrino candidate, spotted with the MicroBooNE detector. Image courtesy Fermilab. An accelerator-born neutrino candidate, spotted with the MicroBooNE detector. Image courtesy Fermilab.

  15. 2014 Annual EM/NE/SC SQA Support Group Meeting | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    4 Annual EM/NE/SC SQA Support Group Meeting 2014 Annual EM/NE/SC SQA Support Group Meeting 2014 Annual EM/NE/SC SQA Support Group Meeting The 2014 Annual Face-to-Face Meeting of the Environmental Management (EM), Nuclear Energy (NE), and Science (SC) Software Quality Assurance (SQA) Support Group (SG) was held May 6-8, 2014. This meeting was hosted by the Office of Safeguards, Security and Emergency Services (OSSES) at the Savannah River Site (SRS). The Chief of Nuclear Safety (CNS) sponsors

  16. 2015 Annual EM/NE/SC SQA Support Group Meeting | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    5 Annual EM/NE/SC SQA Support Group Meeting 2015 Annual EM/NE/SC SQA Support Group Meeting 2015 Annual EM/NE/SC SQA Support Group Meeting The Chief of Nuclear Safety (CNS) formed the Environmental Management (EM), Nuclear Energy (NE), and Science (SC) Software Quality Assurance (SQA) Support Group (SG) in March 2007. The first Annual Meeting was held August 2008. The 8th Annual Meeting will be held May 11-14, 2015. This year the Annual Meeting will be hosted by EM's Office of River Protection in

  17. Demonstration Assessment of LED Roadway Lighting: NE Cully Blvd., Portland, OR

    SciTech Connect

    Royer, M. P.; Poplawski, M. E.; Tuenge, J. R.

    2012-08-01

    GATEWAY program report on a demonstration of LED roadway lighting on NE Cully Boulevard in Portland, OR, a residential collector road.

  18. Princeton graduate student Imène Goumiri creates computer program that

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    helps stabilize fusion plasmas | Princeton Plasma Physics Lab Princeton graduate student Imène Goumiri creates computer program that helps stabilize fusion plasmas By John Greenwald and Raphael Rosen April 14, 2016 Tweet Widget Google Plus One Share on Facebook Imène Goumiri led the design of a controller. (Photo by Elle Starkman/Office of Communications) Imène Goumiri led the design of a controller. Imène Goumiri, a Princeton University graduate student, has worked with physicists at

  19. MiniBooNE's First Oscillation Result Morgan Wascko Imperial College...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    6 July, 2007 Meson Production 9 MiniBooNE Overview * External meson production data * HARP data (CERN) * Parametrisation of cross- sections * Sanford-Wang for pions * Feynman...

  20. 14-07-09 MicroBooNE calibrations.pptx

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    cloud disperse: Diffusion* * Charge loss due to impurities** * Signal on wires * Induction * Collection 090714 MicroBooNE Calibrations, T. Strauss 4 First we need to...

  1. Analysis of Neutral Current 0 Events at MiniBooNE

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Neutral Current π 0 Events at MiniBooNE Colin Anderson April 14, 2008 The Experiment Analysis Outline Experiment MiniBooNE Description NC π 0 Overview Analysis Selection and Reconstruction of Events Rate Measurement Correcting Monte Carlo w/ Data Coherent Fraction Measurement C.E. Anderson MiniBooNE NC π 0 Analysis 2/22 The Experiment Analysis MiniBooNE ν e appearance search designed to confirm or refute the LSND result The Beam 8 GeV p's from Booster beam directed at a Be target Produced π

  2. MiniBooNE: Up and Running Morgan Wascko Morgan Wascko Louisiana...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Wascko Louisiana State University Louisiana State University Morgan O. Wascko, LSU Yang Institute Conference 11 October, 2002 MiniBooNE detector at Fermi National Accelerator...

  3. The MicroBooNE LArTPC Sarah Lockwitz, FNAL

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    MicroBooNE LArTPC Sarah Lockwitz, FNAL 2013 DPF August 15, 2013 DPF: MicroBooNE TPC S. Lockwitz August 15, 2013 MicroBooNE is a LAr TPC * A liquid argon (LAr) time-projection chamber (TPC) * It will be placed in the Booster Neutrino beam at Fermilab * It has both physics and R&D goals: * Physics: High-statistics measurements of ν's on Ar * Investigate MiniBooNE's low- energy excess * R&D: Gain experience building & operating a LArTPC * Will put a near featured efforts 2 Tevatron

  4. Kaon Monitoring in MiniBooNE: The LMC Detector E. D. Zimmerman

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Kaon Monitoring in MiniBooNE: The LMC Detector E. D. Zimmerman University of Colorado NBI 2003 KEK, Tsukuba November 10, 2003 Kaon Monitoring at MiniBooNE 1) K-decay ν e background at BooNE K production estimates 2) Decay kinematics 3) The "Little Muon Counter" (LMC) Concept/Placement Civil construction/infrastructure Collimator Fiber Tracker Temporary detector Status K-decay ν e background MiniBooNE will see ~200-400 ν e from K + and K 0 L decays each year -- comparable to the

  5. Ground Motion Studies at NuMI

    SciTech Connect

    Mayda M. Velasco; Michal Szleper

    2012-02-20

    Ground motion can cause significant deterioration in the luminosity of a linear collider. Vibration of numerous focusing magnets causes continuous misalignments, which makes the beam emittance grow. For this reason, understanding the seismic vibration of all potential LC sites is essential and related efforts in many sites are ongoing. In this document we summarize the results from the studies specific to Fermilab grounds as requested by the LC project leader at FNAL, Shekhar Mishra in FY04-FY06. The Northwestern group focused on how the ground motion effects vary with depth. Knowledge of depth dependence of the seismic activity is needed in order to decide how deep the LC tunnel should be at sites like Fermilab. The measurements were made in the NuMI tunnel, see Figure 1. We take advantage of the fact that from the beginning to the end of the tunnel there is a height difference of about 350 ft and that there are about five different types of dolomite layers. The support received allowed to pay for three months of salary of Michal Szleper. During this period he worked a 100% of his time in this project. That include one week of preparation: 2.5 months of data taking and data analysis during the full period of the project in order to guarantee that we were recording high quality data. We extended our previous work and made more systematic measurements, which included detailed studies on stability of the vibration amplitudes at different depths over long periods of time. As a consequence, a better control and more efficient averaging out of the daytime variation effects were possible, and a better study of other time dependences before the actual depth dependence was obtained. Those initial measurements were made at the surface and are summarized in Figure 2. All measurements are made with equipment that we already had (two broadband seismometers KS200 from GEOTECH and DL-24 portable data recorder). The offline data analysis took advantage of the full Fourier spectra

  6. DOE - Office of Legacy Management -- Mitts-Merrill Co - MI 14

    Office of Legacy Management (LM)

    1993 MI.14-2 Site Operations: Reduced thorium metal chunks into particle sized pieces ... Primary Radioactive Materials Handled: Thorium MI.14-1 Radiological Survey(s): Yes - ...

  7. DOE - Office of Legacy Management -- Mitts-Merrel Co - MI 14

    Office of Legacy Management (LM)

    1993 MI.14-2 Site Operations: Reduced thorium metal chunks into particle sized pieces ... Primary Radioactive Materials Handled: Thorium MI.14-1 Radiological Survey(s): Yes - ...

  8. MiR-125a TNF receptor-associated factor 6 to inhibit osteoclastogenesis

    SciTech Connect

    Guo, Li-Juan; Liao, Lan; Yang, Li; Li, Yu; Jiang, Tie-Jian

    2014-02-15

    MicroRNAs (miRNAs) play important roles in osteoclastogenesis and bone resorption. In the present study, we found that miR-125a was dramatically down-regulated during macrophage colony stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ligand (RANKL) induced osteoclastogenesis of circulating CD14+ peripheral blood mononuclear cells (PBMCs). Overexpression of miR-125a in CD14+ PBMCs inhibited osteoclastogenesis, while inhibition of miR-125a promoted osteoclastogenesis. TNF receptor-associated factor 6 (TRAF6), a transduction factor for RANKL/RANK/NFATc1 signal, was confirmed to be a target of miR-125a. EMSA and ChIP assays confirmed that NFATc1 bound to the promoter of the miR-125a. Overexpression of NFATc1 inhibited miR-125a transcription, and block of NFATc1 expression attenuated RANKL-regulated miR-125a transcription. Here, we reported that miR-125a played a biological function in osteoclastogenesis through a novel TRAF6/ NFATc1/miR-125a regulatory feedback loop. It suggests that regulation of miR-125a expression may be a potential strategy for ameliorating metabolic disease. - Highlights: • MiR-125a was significantly down-regulated in osteoclastogenesis of CD14+ PBMCs. • MiR-125a inhibited osteoclast differentiation by targeting TRAF6. • NFATc1 inhibited miR-125a transciption by binding to the promoter of miR-125a. • TRAF6/NFATc1 and miR-125a form a regulatory feedback loop in osteoclastogenesis.

  9. Port Huron, MI Liquefied Natural Gas Exports (Million Cubic Feet...

    Energy Information Administration (EIA) (indexed site)

    (Million Cubic Feet) Port Huron, MI Liquefied Natural Gas Exports (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2013 1 2014 1 1 1 1 2 1 1 1 1 1 2015 1 1...

  10. Neutron scattering study of spin ordering and stripe pinning in superconducting <mi>La>1.93<mi>Sr>0.07<mi>CuO>4

    SciTech Connect

    Jacobsen, H.; Zaliznyak, I. A.; Savici, A. T.; Winn, B. L.; Chang, S.; Hücker, M.; Gu, G. D.; Tranquada, J. M.

    2015-11-20

    The relationships among charge order, spin fluctuations, and superconductivity in underdoped cuprates remain controversial. We use neutron scattering techniques to study these phenomena in <mi>La>1.93<mi>Sr>0.07<mi>CuO>4 a superconductor with a transition temperature of Tc = 20 K. At T<< Tc, we find incommensurate spin fluctuations with a quasielastic energy spectrum and no sign of a gap within the energy range from 0.2 to 15 meV. A weak elastic magnetic component grows below ~ 10 K, consistent with results from local probes. Regarding the atomic lattice, we have discovered unexpectedly strong fluctuations of the CuO6 octahedra about Cu-O bonds, which are associated with inequivalent O sites within the CuO2 planes. Moreover, we observed a weak elastic (3 30) superlattice peak that implies a reduced lattice symmetry. The presence of inequivalent O sites rationalizes various pieces of evidence for charge stripe order in underdoped La2-xSrxCuO4. The coexistence of superconductivity with quasi-static spin-stripe order suggests the presence of intertwined orders; however, the rotation of the stripe orientation away from the Cu-O bonds might be connected with evidence for a finite gap at the nodal points of the superconducting gap function.

  11. MiR-145 functions as a tumor suppressor targeting NUAK1 in human intrahepatic cholangiocarcinoma

    SciTech Connect

    Xiong, Xinkui; Sun, Daoyi; Chai, Hao; Shan, Wengang; Yu, Yue; Pu, Liyong; Cheng, Feng

    2015-09-18

    The dysregulation of micro (mi)RNAs is associated with cancer development. The miRNA miR-145 is downregulated in intrahepatic cholangiocarcinoma (ICC); however, its precise role in tumor progression has not yet been elucidated. Novel (nua) kinase family (NUAK)1 functions as an oncogene in various cancers and is a putative target of miR-145 regulation. In this study, we investigated the regulation of NUAK1 by miR-145 in ICC. We found that miR-145 level was significantly decreased in ICC tissue and cell lines, which corresponded with an increase in NUAK1 expression. NUAK1 was found to be a direct target of miR-145 regulation. The overexpression of miR-145 in ICC cell lines inhibited proliferation, growth, and invasion by suppressing NUAK1 expression, which was associated with a decrease in Akt signaling and matrix metalloproteinase protein expression. Similar results were observed by inhibiting NUAK1 expression. These results demonstrate that miR-145 can prevent ICC progression by targeting NUAK1 and its downstream effectors, and can therefore be useful for clinical diagnosis and targeted therapy of ICC. - Highlights: • MiR-145 suppresses ICC proliferation and invasion abilities. • We demonstrated that miR-145 directly targets NUAK1 in ICC. • MiR-145 expression in ICC was associated with Akt signaling and MMPs expression.

  12. Radiosensitizing Effects of Ectopic miR-101 on Non-Small-Cell Lung Cancer Cells Depend on the Endogenous miR-101 Level

    SciTech Connect

    Chen, Susie; Wang Hongyan; Ng, Wooi Loon; Curran, Walter J.; Wang Ya

    2011-12-01

    Purpose: Previously, we showed that ectopic miR-101 could sensitize human tumor cells to radiation by targeting ATM and DNA-PK catalytic subunit (DNA-PKcs) to inhibit DNA repair, as the endogenous miR-101 levels are low in tumors in general. However, the heterogeneity of human cancers may result in an exception. The purpose of this study was to test the hypothesis that a few tumor cell lines with a high level of endogenous miR-101 would prove less response to ectopic miR-101. Methods and Materials: Fourteeen non-small-cell lung cancer (NSCLC) cell lines and one immortalized non-malignant lung epithelial cell line (NL20) were used for comparing endogenous miR-101 levels by real-time reverse transcription-polymerase chain reaction. Based on the different miR-101 levels, four cell lines with different miR-101 levels were chosen for transfection with a green fluorescent protein-lentiviral plasmid encoding miR-101. The target protein levels were measured by using Western blotting. The radiosensitizing effects of ectopic miR-101 on these NSCLC cell lines were determined by a clonogenic assay and xenograft mouse model. Results: The endogenous miR-101 level was similar or lower in 13 NSCLC cell lines but was 11-fold higher in one cell line (H157) than in NL20 cells. Although ectopic miR-101 efficiently decreased the ATM and DNA-PKcs levels and increased the radiosensitization level in H1299, H1975, and A549 cells, it did not change the levels of the miR-101 targets or radiosensitivity in H157 cells. Similar results were observed in xenograft mice. Conclusions: A small number of NSCLC cell lines could have a high level of endogenous miR-101. The ectopic miR-101 was able to radiosensitize most NSCLC cells, except for the NSCLC cell lines that had a much higher endogenous miR-101 level. These results suggest that when we choose one miRNA as a therapeutic tool, the endogenous level of the miRNA in each tumor should be considered.

  13. THE GENESIS SOLAR WIND CONCENTRATOR TARGET: MASS FRACTIONATION CHARACTERISED BY NE ISOTOPES

    SciTech Connect

    WIENS, ROGER C.; OLINGER, C.; HEBER, V.S.; REISENFELD, D.B.; BURNETT, D.S.; ALLTON, J.H.; BAUR, H.; WIECHERT, U.; WIELER, R.

    2007-01-02

    The concentrator on Genesis provides samples of increased fluences of solar wind ions for precise determination of the oxygen isotopic composition of the solar wind. The concentration process caused mass fractionation as function of the radial target position. They measured the fractionation using Ne released by UV laser ablation along two arms of the gold cross from the concentrator target to compare measured Ne with modeled Ne. The latter is based on simulations using actual conditions of the solar wind during Genesis operation. Measured Ne abundances and isotopic composition of both arms agree within uncertainties indicating a radial symmetric concentration process. Ne data reveal a maximum concentration factor of {approx} 30% at the target center and a target-wide fractionation of Ne isotopes of 3.8%/amu with monotonously decreasing {sup 20}Ne/{sup 22}Ne ratios towards the center. The experimentally determined data, in particular the isotopic fractionation, differ from the modeled data. They discuss potential reasons and propose future attempts to overcome these disagreements.

  14. PPARγ inhibits ovarian cancer cells proliferation through upregulation of miR-125b

    SciTech Connect

    Luo, Shuang; Wang, Jidong; Ma, Ying; Yao, Zhenwei; Pan, Hongjuan

    2015-06-26

    miR-125b has essential roles in coordinating tumor proliferation, angiogenesis, invasiveness, metastasis and chemotherapy recurrence. In ovarian cancer miR-125b has been shown to be downregulated and acts as a tumor suppressor by targeting proto-oncogene BCL3. PPARγ, a multiple functional transcription factor, has been reported to have anti-tumor effects through inhibition of proliferation and induction of differentiation and apoptosis by targeting the tumor related genes. However, it is unclear whether miR-125b is regulated by PPARγ in ovarian cancer. In this study, we demonstrated that the miR-125b downregulated in ovarian cancer tissues and cell lines. Ligands-activated PPARγ suppressed proliferation of ovarian cancer cells and this PPARγ-induced growth inhibition is mediated by the upregulation of miR-125b. PPARγ promoted the expression of miR-125b by directly binding to the responsive element in miR-125b gene promoter region. Thus, our results suggest that PPARγ can induce growth suppression of ovarian cancer by upregulating miR-125b which inhibition of proto-oncogene BCL3. These findings will extend our understanding of the function of PPARγ in tumorigenesis and miR-125b may be a therapeutic intervention of ovarian cancer. - Highlights: • miR-125b is down-regulated in ovarian cancer tissues and cells. • PPARγ upregulates miR-125b and downregulates its target gene BCL3 expression. • Silence of miR-125b attenuates PPARγ-mediated growth suppression of ovarian cancer cells. • PPARγ promotes the transcription of miR-125b via binding to PPARE in miR-125b gene promoter region.

  15. The Ne-to-O abundance ratio of the interstellar medium from IBEX-Lo observations

    SciTech Connect

    Park, J.; Kucharek, H.; Möbius, E.; Leonard, T.; Bzowski, M.; Sokół, J. M.; Kubiak, M. A.; Fuselier, S. A.; McComas, D. J.

    2014-11-01

    In this paper we report on a two-year study to estimate the Ne/O abundance ratio in the gas phase of the local interstellar cloud (LIC). Based on the first two years of observations with the Interstellar Boundary Explorer, we determined the fluxes of interstellar neutral (ISN) O and Ne atoms at the Earth's orbit in spring 2009 and 2010. A temporal variation of the Ne/O abundance ratio at the Earth's orbit could be expected due to solar cycle-related effects such as changes of ionization. However, this study shows that there is no significant change in the Ne/O ratio at the Earths orbit from 2009 to 2010. We used time-dependent survival probabilities of the ISNs to calculate the Ne/O abundance ratio at the termination shock. Then we estimated the Ne/O abundance ratio in the gas phase of the LIC with the use of filtration factors and the ionization fractions. From our analysis, the Ne/O abundance ratio in the LIC is 0.33 ± 0.07, which is in agreement with the abundance ratio inferred from pickup-ion measurements.

  16. Level-resolved R-matrix calculations for the electron-impact excitation of Ne{sup 3+} and Ne{sup 6+}

    SciTech Connect

    Ludlow, J. A.; Lee, T. G.; Ballance, C. P.; Loch, S. D.; Pindzola, M. S.

    2011-08-15

    Large-scale R-matrix calculations are carried out for the electron-impact excitation of Ne{sup 3+} and Ne{sup 6+}. For Ne{sup 3+}, a 581-LSJ-level R-matrix intermediate coupling frame transformation calculation is made for excitations up to the n=4 shell. For some transitions, large effective collision strength differences are found with current 23-jKJ-level Breit-Pauli R-matrix and earlier 22-LSJ-level R-matrix jj omega (JAJOM) calculations. For Ne{sup 6+}, a 171-jKJ-level Breit-Pauli R-matrix calculation is made for excitations up to the n=5 shell. For some transitions, large effective collision strength differences are found with current 46-jKJ-level Breit-Pauli R-matrix and earlier 46-LSJ-level R-matrix JAJOM calculations. Together with existing R-matrix calculations for other ion stages, high-quality excitation data are now available for astrophysical and laboratory plasma modeling along the entire Ne isonuclear sequence.

  17. Geoffrey Mills Los Alamos National Laboratory For the MiniBooNE Collaboration

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ICHEP Paris, France XXV Juillet, MMX New Observations from the MiniBooNE Experiment 1. Motivation 2. MiniBooNE Appearance Results 3. Comparison of LSND and MiniBooNE 4. Future Possibilities 5. Conclusions Neutrino Oscillations The oscillation patterns between the 3 known active neutrino species have been demonstrated by a number of experiments over the last two decades: SNO, Kamland Super-K, K2K, MINOS Armed with that knowledge, measurements of neutrino behavior outside the standard 3

  18. Geoffrey Mills Los Alamos National Laboratory For the MiniBooNE Collaboration

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    SLAC XXIV August MMX New Observations from the MiniBooNE Experiment 1. Motivation 2. MiniBooNE Appearance Results 3. Comparison of LSND and MiniBooNE 4. Future Possibilities 5. Conclusions Neutrino Oscillations " The oscillation patterns between the 3 known active neutrino species have been demonstrated by a number of experiments over the last two decades: " SNO, Kamland " Super-K, K2K, MINOS " Armed with that knowledge, measurements of neutrino behavior outside the standard

  19. Geoffrey Mills Los Alamos National Laboratory For the MiniBooNE Collaboration

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    NeuTel2011 Venezia, Italia Results from the MiniBooNE Experiment 1. Motivation 2. MiniBooNE Appearance Results 3. Comparison of LSND and MiniBooNE 4. Future Possibilities 5. Conclusions Mesdames et Mes Neutrino Oscillations " The oscillation patterns between the 3 known active neutrino species have been demonstrated by a number of experiments over the last two decades: " SNO, Kamland " Super-K, K2K, MINOS " Armed with that knowledge, measurements of neutrino behavior outside

  20. /Users/jzennamo/Desktop/ObsLimit_MiniSciBooNE_SBN_numuDis.pdf

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    µ θ 2 2 sin 3 - 10 2 - 10 1 - 10 1 ] 2 [eV 2 m ∆ 1 - 10 1 10 2 10 POT) 20 10 × POT) and T600 (6.6 21 10 × MicroBooNE (1.3 POT) 20 10 × LAr1-ND (6.6 mode, CC Events ν Stat, Flux, Cross Section Uncerts. Reconstructed Energy Efficiency µ ν 80% Shape and Rate 90% CL CL σ 3 CL σ 5 MiniBooNE + SciBooNE 90% CL

  1. MiniBooNE Anti-Neutrino CCQE Cross Section Data Release

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Anti-Neutrino Double-Differential Charged Current Quasi-Elastic Cross Section", arXiv:1301.7067 [hep-ex] The following MiniBooNE information from the anti-neutrino CCQE cross section paper is made available to the public: νμ CCQE data: MiniBooNE flux table of MiniBooNE anti-neutrino mode flux by neutrino species (Figure 1 and Tables XI-XII). Note that, based on the constraints of the in situ measurements, the muon neutrino flux spectrum given here should be scaled by 0.77. flux-integrated

  2. File:USDA-CE-Production-GIFmaps-NE.pdf | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    NE.pdf Jump to: navigation, search File File history File usage Nebraska Ethanol Plant Locations Size of this preview: 776 600 pixels. Full resolution (1,650 1,275 pixels,...

  3. MiniBooNE H. A. Tanaka Princeton University Neutrino Factory...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    H. A. Tanaka Princeton University Neutrino Factory 2004 Osaka, Japan The MiniBooNE ... J.L.Raaf University of Colorado: T.Hart, R.H.Nelson, M.Wilking, E.D.Zimmerman Columbia ...

  4. DOE-NE Light Water Reactor Sustainability Program and EPRI Long...

    Office of Environmental Management (EM)

    DOE-NE Light Water Reactor Sustainability Program and EPRI Long-Term Operations Program - Joint Research and Development Plan Nuclear power has contributed almost 20% of the total ...

  5. REPLY TO ATTN OF: NE-24 L SUBJECT: Authorization to Conduct Remedial...

    Office of Legacy Management (LM)

    Government '--Department of Energy | memorandum 4 ' It) |1 e0i78 DATE: OCT 9 1984 REPLY TO ATTN OF: NE-24 L SUBJECT: Authorization to Conduct Remedial Action at Vicinity...

  6. ARM - Field Campaign - 2001 Philadelphia NE-OPS Air Quality Experiment

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Philadelphia NE-OPS Air Quality Experiment ARM Data Discovery Browse Data Comments? We would love to hear from you Send us a note below or call us at 1-888-ARM-DATA. Send Campaign...

  7. Application for Presidential Permit PP-400 TDI-NE - New England...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    PP-400 TDI-NE - New England Clean Power Link Project - Motion to Intervene and Comments of the Vermont Department of Public Service - August 6, 2014 Application for Presidential ...

  8. Morgan Wascko Imperial College London MiniBooNE's First Neutrino...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    MiniBooNE's First Neutrino Oscillation Result Morgan Wascko CalTech Physics Research Conference 26 April, 2007 Outline * A short course in the physics of oscillations * What are ...

  9. 35 COFibE, Series A. U. S. ATOXIC ENERGY CCMMISSION r'C Cj NE...

    Office of Legacy Management (LM)

    COFibE, Series A. - U. S. ATOXIC ENERGY CCMMISSION r'C Cj NE YORK OPERATIONS OFFICE ... Klscc Seuage Plant A study was nade at Ut. Kiszo, Ncu Kor% of radium rearmal efficiency by ...

  10. ENERGY MEASUREMENTS GROUP EG&G SURVEY REPORT NE-F-003

    Office of Legacy Management (LM)

    * * nEGc.G ENERGY MEASUREMENTS GROUP EG&G SURVEY REPORT NE-F-003 FEBRUARY 1983 THE REMOTE SENSING LABORATORY OF THE UNITED STATES DEPARTMENT OF ENERGY AN AERIAL RADIOLOGICAL ...

  11. MiniBooNE NC 1?0 Cross Section Data Release

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    0 production cross sections on mineral oil at EO(1 GeV)", arXiv:0911.2063 hep-ex, Phys. Rev. D81, 013005 (2010) The following MiniBooNE information from the 2009 NC 10...

  12. Fermilab | Newsroom | Press Releases | June 24, 2014: MicroBooNE...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    jpeg images. When using these images, please credit each photo as indicated. Med Res | Hi Res The 30-ton MicroBooNE neutrino detector was transported across the Fermilab site on...

  13. Application for Presidential Permit OE Docket No. PP-400 TDI-NE - New

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    England Clean Power Link Project: Federal Register Notice, Volume 79, No. 131 - July 9, 2014 | Department of Energy - New England Clean Power Link Project: Federal Register Notice, Volume 79, No. 131 - July 9, 2014 Application for Presidential Permit OE Docket No. PP-400 TDI-NE - New England Clean Power Link Project: Federal Register Notice, Volume 79, No. 131 - July 9, 2014 Application from TDI-NE to construct, operate and maintain electric transmission facilities at the U.S. - Canada

  14. Application for Presidential Permit PP-400 TDI-NE - New England Clean Power

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Link Project - Motion to Intervene and Comments of the Vermont Department of Public Service - August 6, 2014 | Department of Energy PP-400 TDI-NE - New England Clean Power Link Project - Motion to Intervene and Comments of the Vermont Department of Public Service - August 6, 2014 Application for Presidential Permit PP-400 TDI-NE - New England Clean Power Link Project - Motion to Intervene and Comments of the Vermont Department of Public Service - August 6, 2014 The Vermont Department of

  15. 2013 Annual DOE-NE Materials Research Coordination Meeting | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energy Annual DOE-NE Materials Research Coordination Meeting 2013 Annual DOE-NE Materials Research Coordination Meeting The Reactor Materials element of the Nuclear Energy Enabling Technologies (NEET) program conducted its FY 2013 coordination meeting as a series of four web-conferences to act as a forum for the nuclear materials research community. The purpose of this meeting was to report on current and planned nuclear materials research, identify new areas of collaboration and promote

  16. Princeton graduate student Imène Goumiri creates computer program that

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    helps stabilize fusion plasmas | Princeton Plasma Physics Lab Princeton graduate student Imène Goumiri creates computer program that helps stabilize fusion plasmas By John Greenwald and Raphael Rosen April 14, 2016 Tweet Widget Google Plus One Share on Facebook Imène Goumiri, a Princeton University graduate student, has worked with physicists at the U.S. Department of Energy's (DOE) Princeton Plasma Physics Laboratory (PPPL) to simulate a method for limiting instabilities that reduce the

  17. 2015 ANNUAL DOE-NE MATERIALS RESEARCH MEETING | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ANNUAL DOE-NE MATERIALS RESEARCH MEETING 2015 ANNUAL DOE-NE MATERIALS RESEARCH MEETING The Reactor Materials element of the Nuclear Energy Enabling Technologies (NEET) program conducted its FY 2015 coordination meeting as a series of two web-conferences to act as a forum for the nuclear materials research community. The purpose of this meeting was to report on current and planned nuclear materials research, identify new areas of collaboration and promote greater coordination among the various

  18. Introduction to MiniBooNE and Charged Current Quasi-Elastic (CCQE) Results

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    MiniBooNE and ν μ Charged Current Quasi-Elastic (CCQE) Results Byron P. Roe University of Michigan For the MiniBooNE collaboration 2 University of Alabama Los Alamos National Laboratory Bucknell University Louisiana State University University of Cincinnati University of Michigan University of Colorado Princeton University Columbia University Saint Mary's University of Minnesota Embry Riddle University Virginia Polytechnic Institute Fermi National Accelerator Laboratory Western Illinois

  19. WC_2000_001_CLASS_WAIVER_BETWEEN_DOE_and_EMPLOYEES_OF_THE_NE.pdf |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy 2000_001_CLASS_WAIVER_BETWEEN_DOE_and_EMPLOYEES_OF_THE_NE.pdf WC_2000_001_CLASS_WAIVER_BETWEEN_DOE_and_EMPLOYEES_OF_THE_NE.pdf (486.67 KB) More Documents & Publications Class_Waiver_W_C-2000-001.pdf WC_1994_010__CLASS_WAIVER_of_the_Governments_Patent_Rights_.pdf WC_1994_001_CLASS_WAIVER_OF_THE_Governments_Patent_Rights_i

  20. Genome-Wide Analysis of miRNA targets in Brachypodium and Biomass Energy Crops

    SciTech Connect

    Green, Pamela J.

    2015-08-11

    MicroRNAs (miRNAs) contribute to the control of numerous biological processes through the regulation of specific target mRNAs. Although the identities of these targets are essential to elucidate miRNA function, the targets are much more difficult to identify than the small RNAs themselves. Before this work, we pioneered the genome-wide identification of the targets of Arabidopsis miRNAs using an approach called PARE (German et al., Nature Biotech. 2008; Nature Protocols, 2009). Under this project, we applied PARE to Brachypodium distachyon (Brachypodium), a model plant in the Poaceae family, which includes the major food grain and bioenergy crops. Through in-depth global analysis and examination of specific examples, this research greatly expanded our knowledge of miRNAs and target RNAs of Brachypodium. New regulation in response to environmental stress or tissue type was found, and many new miRNAs were discovered. More than 260 targets of new and known miRNAs with PARE sequences at the precise sites of miRNA-guided cleavage were identified and characterized. Combining PARE data with the small RNA data also identified the miRNAs responsible for initiating approximately 500 phased loci, including one of the novel miRNAs. PARE analysis also revealed that differentially expressed miRNAs in the same family guide specific target RNA cleavage in a correspondingly tissue-preferential manner. The project included generation of small RNA and PARE resources for bioenergy crops, to facilitate ongoing discovery of conserved miRNA-target RNA regulation. By associating specific miRNA-target RNA pairs with known physiological functions, the research provides insights about gene regulation in different tissues and in response to environmental stress. This, and release of new PARE and small RNA data sets should contribute basic knowledge to enhance breeding and may suggest new strategies for improvement of biomass energy crops.

  1. DLEU2, frequently deleted in malignancy, functions as a critical host gene of the cell cycle inhibitory microRNAs miR-15a and miR-16-1

    SciTech Connect

    Lerner, Mikael; Harada, Masako; Loven, Jakob; Castro, Juan; Davis, Zadie; Oscier, David; Henriksson, Marie; Sangfelt, Olle; Grander, Dan; Corcoran, Martin M.

    2009-10-15

    The microRNAs miR-15a and miR-16-1 are downregulated in multiple tumor types and are frequently deleted in chronic lymphocytic leukemia (CLL), myeloma and mantle cell lymphoma. Despite their abundance in most cells the transcriptional regulation of miR-15a/16-1 remains unclear. Here we demonstrate that the putative tumor suppressor DLEU2 acts as a host gene of these microRNAs. Mature miR-15a/miR-16-1 are produced in a Drosha-dependent process from DLEU2 and binding of the Myc oncoprotein to two alterative DLEU2 promoters represses both the host gene transcript and levels of mature miR-15a/miR-16-1. In line with a functional role for DLEU2 in the expression of the microRNAs, the miR-15a/miR-16-1 locus is retained in four CLL cases that delete both promoters of this gene and expression analysis indicates that this leads to functional loss of mature miR-15a/16-1. We additionally show that DLEU2 negatively regulates the G1 Cyclins E1 and D1 through miR-15a/miR-16-1 and provide evidence that these oncoproteins are subject to miR-15a/miR-16-1-mediated repression under normal conditions. We also demonstrate that DLEU2 overexpression blocks cellular proliferation and inhibits the colony-forming ability of tumor cell lines in a miR-15a/miR-16-1-dependent way. Together the data illuminate how inactivation of DLEU2 promotes cell proliferation and tumor progression through functional loss of miR-15a/miR-16-1.

  2. Microfluidic Molecular Assay Platform for the Detection of miRNAs...

    Office of Scientific and Technical Information (OSTI)

    Article: Microfluidic Molecular Assay Platform for the Detection of miRNAs, mRNAs, Proteins, and Post-translational Modifications at Single-cell Resolution. Citation Details...

  3. DOE - Office of Legacy Management -- Baker-Perkins Co - MI 13

    Office of Legacy Management (LM)

    Site Disposition: Eliminated - Potential for contamination remote based on limited scope of activities at the site MI.13-3 Radioactive Materials Handled: Yes Primary ...

  4. miR-4295 promotes cell proliferation and invasion in anaplastic thyroid carcinoma via CDKN1A

    SciTech Connect

    Shao, Mingchen; Geng, Yiwei; Lu, Peng; Xi, Ying; Wei, Sidong; Wang, Liuxing; Fan, Qingxia; Ma, Wang

    2015-09-04

    MicroRNAs (miRNAs) play important roles in the pathogenesis of many types of cancers by negatively regulating gene expression at posttranscriptional level. However, the role of microRNAs in anaplastic thyroid carcinoma (ATC), has remained elusive. Here, we identified that miR-4295 promotes ATC cell proliferation by negatively regulates its target gene CDKN1A. In ATC cell lines, CCK-8 proliferation assay indicated that the cell proliferation was promoted by miR-4295, while miR-4295 inhibitor significantly inhibited the cell proliferation. Transwell assay showed that miR-4295 mimics significantly promoted the migration and invasion of ATC cells, whereas miR-4295 inhibitors significantly reduced cell migration and invasion. luciferase assays confirmed that miR-4295 directly bound to the 3'untranslated region of CDKN1A, and western blotting showed that miR-4295 suppressed the expression of CDKN1A at the protein levels. This study indicated that miR-4295 negatively regulates CDKN1A and promotes proliferation and invasion of ATC cell lines. Thus, miR-4295 may represent a potential therapeutic target for ATC intervention. - Highlights: • miR-4295 mimics promote the proliferation and invasion of ATC cells. • miR-4295 inhibitors inhibit the proliferation and invasion of ATC cells. • miR-4295 targets 3′UTR of CDKN1A in ATC cells. • miR-4295 negatively regulates CDKN1A in ATC cells.

  5. Groundwater protection for the NuMI project

    SciTech Connect

    Wehmann, A.; Smart, W.; Menary, S.; Hylen, J.; Childress, S.

    1997-10-01

    The physics requirements for the long base line neutrino oscillation experiment MINOS dictate that the NuMI beamline be located in the aquifer at Fermilab. A methodology is described for calculating the level of radioactivation of groundwater caused by operation of this beamline. A conceptual shielding design for the 750 meter long decay pipe is investigated which would reduce radioactivation of the groundwater to below government standards. More economical shielding designs to meet these requirements are being explored. Also, information on local geology, hydrogeology, government standards, and a glossary have been included.

  6. Antineutrino Neutral Current Interactions in MiniBooNE

    SciTech Connect

    Dharmapalan, Ranjan

    2012-01-01

    This dissertation reports the antineutrino-nucleus neutral current elastic scattering cross section on CH2 measured by the MiniBooNE experiment located in Batavia, IL. The data set consists of 60,605 events passing the selection cuts corresponding to 10.1×1020 POT, which represents the world’s largest sample of antineutrino neutral current elastic scattering events. The final sample is more than one order of magnitude lager that the previous antineutrino NCE scattering cross section measurement reported by the BNL E734 experiment. The measurement presented in this dissertation also spans a wider range in Q2, including the low-Q2 regime where the cross section rollover is clearly visible. A X2-based minimization was performed to determine the best value of the axial mass, MA and the Pauli blocking scaling function, that matches the antineutrino NCE scattering data. However, the best fit values of MA=1.29 GeV and K=1.026 still give a relatively poor X2, which suggests that the underlying nuclear model (based largely on the relativistic Fermi gas model) may not be an accurate representation for this particular interaction. Additionally, we present a measurement of the antineutrino/neutrino-nucleus NCE scattering cross section ratio. The neutrino mode NCE sample used in this study, corresponding to 6.4 × 1020 POT, is also the world’s largest sample (also by an order of magnitude). We have demonstrated that the ratio measurement is robust, as most of the correlated errors cancel, as expected. Furthermore, this ratio also proves to be rather insensitive to variations in the axial mass and the Pauli blocking parameter. This is the first time that this ratio has been experimentally reported. We believe this measurement will aid the theoretical physics community to test various model predictions of neutrino-nucleon/nucleus interactions.

  7. padd map

    Energy Information Administration (EIA) (indexed site)

    FL PADD 4: Rocky Mountain PADD 5: West Coast PADD 2: Midwest PADD 1: East Coast PADD 3: Gulf Coast PADD1A: New England PADD1B: Central Atlantic PADD1C: Lower Atlantic Petroleum Administration for Defense Districts AK HI WA OR CA NV AZ MT WY CO UT ID ND SD NE KS OK MO MN WI MI IL IN OH KY TN IA NM TX AR LA AL MS WV VA NC SC GA FL ME NH VT NY PA NJ MD DE MA CT RI

  8. Print

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    5k 0 < 50k < 100k < 250k < 500k < 1M > 1M > 5M > 10M DE MD DC MA RI NJ AZ UT WY ID OR WA CA TX OK KS CO NE SD ND MN WI IL IA MO AR LA MS AL FL GA TN KY IN OH MI ME NH CT VT NY PA WV VA NC SC MT AK HI NV NM Princeton Plasma Physics Laboratory Procured Materials and Services 2015 (> $35M) Small business procurements in US: $14.73M

  9. Buildings Energy Data Book: 3.9 Educational Facilities

    Buildings Energy Data Book

    6 2010 Regional New Construction and Renovations Expenditures for Public K-12 Schools ($Million) Region New Schools Additions Renovation Total Region 1 (CT, MA, ME, NH, RI, VT) Region 2 (NJ, NY, PA) Region 3 (DE, MD, VA, WV) Region 4 (KY, NC, SC, TN) Region 5 (AL, FL, GA, MS) Region 6 (IN, MI, OH) Region 7 (IL, MN, WI) Region 8 (IA, KS, MO, NE) Region 9 (AR, LA, OK, TX) Region 10 (CO, MT, ND, NM, SD, UT, WY) Region 11 (AZ, CA, HI, NV) Region 12 (AK, ID, OR, WA) Total Source(s): School Planning

  10. Department of Energy (DOE) OpenNet documents

    Office of Scientific and Technical Information (OSTI)

    Account Request *First Name: *Last Name: *Organization: *Phone: *Email: Fax: *Address: *City: *State: Select AL AK AZ AR CA CO CT DE DC FL GA HI ID IL IN IA KS KY LA ME MD MA MI MN MS MO MT NE NV NH NJ NM NY NC ND OH OK OR PA RI SC SD TN TX UT VT VA WA WV WI WY Zip Code: *Affiliation: Select Federal Contractor *Access Level: Select View Release Official Releasing Official: release *Site Input Code: Select A2EDAP - Atmosphere to Electrons (A2e) Data Archive and Portal, Pacific Northwest National

  11. Figure F5. Oil and gas supply model regions

    Gasoline and Diesel Fuel Update

    6 Appendix F Figure F5. Oil and gas supply model regions Figure F4. Oil and Gas Supply Model Regions Atlantic WA MT WY ID NV UT CO AZ NM TX OK IA KS MO IL IN KY TN MS AL FL GA SC NC WV PA NJ MD DE NY CT ME RI MA NH VA WI MI OH NE SD MN ND AR LA OR CA VT Northeast (1) Gulf of Mexico Gulf Coast (2) Midcontinent (3) Rocky Mountain (5) West Coast (6) Pacific Offshore North Slope AK TX TX NM TX Southwest (4) Onshore North Slope Other Alaska Source: U.S. Energy Information Administration, Office of

  12. Other Participants 2001 | U.S. DOE Office of Science (SC)

    Office of Science (SC)

    , Great Falls , MT Chaska High School , Chaska , MN Creighton Preparatory School , Omaha , NE DuPont Manual Magnet High School , Louisville , KY East Brunswick High School , ...

  13. MiR-153 inhibits migration and invasion of human non-small-cell lung cancer by targeting ADAM19

    SciTech Connect

    Shan, Nianxi; Shen, Liangfang; Wang, Jun; He, Dan; Duan, Chaojun

    2015-01-02

    Highlights: • Decreased miR-153 and up-regulated ADAM19 are correlated with NSCLC pathology. • MiR-153 inhibits the proliferation and migration and invasion of NSCLC cells in vitro. • ADAM19 is a direct target of miR-153. • ADAM19 is involved in miR-153-suppressed migration and invasion of NSCLC cells. - Abstract: MiR-153 was reported to be dysregulated in some human cancers. However, the function and mechanism of miR-153 in lung cancer cells remains unknown. In this study, we investigated the role of miR-153 in human non-small-cell lung cancer (NSCLC). Using qRT-PCR, we demonstrated that miR-153 was significantly decreased in clinical NSCLC tissues and cell lines, and downregulation of miR-153 was significantly correlated with lymph node status. We further found that ectopic expression of miR-153 significantly inhibited the proliferation and migration and invasion of NSCLC cells in vitro, suggesting that miR-153 may be a novel tumor suppressor in NSCLC. Further integrated analysis revealed that ADAM19 is as a direct and functional target of miR-153. Luciferase reporter assay demonstrated that miR-153 directly targeted 3′UTR of ADAM19, and correlation analysis revealed an inverse correlation between miR-153 and ADAM19 mRNA levels in clinical NSCLC tissues. Knockdown of ADAM19 inhibited migration and invasion of NSCLC cells which was similar with effects of overexpression of miR-153, while overexpression of ADAM19 attenuated the function of miR-153 in NSCLC cells. Taken together, our results highlight the significance of miR-153 and ADAM19 in the development and progression of NSCLC.

  14. miR-129 suppresses tumor cell growth and invasion by targeting PAK5 in hepatocellular carcinoma

    SciTech Connect

    Zhai, Jian; Qu, Shuping; Li, Xiaowei; Zhong, Jiaming; Chen, Xiaoxia; Qu, Zengqiang; Wu, Dong

    2015-08-14

    Emerging evidence suggests that microRNAs (miRNAs) play important roles in regulating HCC development and progression; however, the mechanisms by which their specific functions and mechanisms remained to be further explored. miR-129 has been reported in gastric cancers, lung cancer and colon cancer. In this study, we disclosed a new tumor suppresser function of miR-129 in HCC. We also found the downregulation of miR-129 occurred in nearly 3/4 of the tumors examined (56/76) compared with adjacent nontumorous tissues, which was more importantly, correlated to the advanced stage and vascular invasion. We then demonstrated that miR-129 overexpression attenuated HCC cells proliferation and invasion, inducing apoptosis in vitro. Moreover, we used miR-129 antagonist and found that anti-miR-129 promoted HCC cells malignant phenotypes. Mechanistically, our further investigations revealed that miR-129 suppressed cell proliferation and invasion by targeting the 3’-untranslated region of PAK5, as well as miR-129 silencing up-regulated PAK5 expression. Moreover, miR-129 expression was inversely correlated with PAK5 expression in 76 cases of HCC samples. RNA interference of PAK5 attenuated anti-miR-129 mediated cell proliferation and invasion in HCC cells. Taken together, these results demonstrated that miR-129 suppressed tumorigenesis and progression by directly targeting PAK5, defining miR-129 as a potential treatment target for HCC. - Highlights: • Decreased of miR-129 is found in HCC and associated with advanced stage and metastasis. • miR-129 suppresses proliferation and invasion of HCC cells. • miR-129 directly targets the 3′ UTR of PAK5 and diminishes PAK5 expression. • PAK5 is involved in miR-129 mediated suppression functions.

  15. Transcriptional regulation of miR-146b by C/EBPβ LAP2 in esophageal cancer cells

    SciTech Connect

    Li, Junxia; Shan, Fabo; Xiong, Gang; Wang, Ju-Ming; Wang, Wen-Lin; Xu, Xueqing; Bai, Yun

    2014-03-28

    Highlights: • MiR-146b promotes esophageal cancer cell proliferation. • MiR-146b inhibits esophageal cancer cell apoptosis. • C/EBPβ directly binds to miR-146b promoter conserved region. • MiR-146b is up-regulated by C/EBPβ LAP2 transcriptional activation. - Abstract: Recent clinical study indicated that up-regulation of miR-146b was associated with poor overall survival of patients in esophageal squamous cell carcinoma. However, the underlying mechanism of miR-146b dysregulation remains to be explored. Here we report that miR-146b promotes cell proliferation and inhibits cell apoptosis in esophageal cancer cell lines. Mechanismly, two C/EBPβ binding motifs are located in the miR-146b promoter conserved region. Among the three isoforms of C/EBPβ, C/EBPβ LAP2 positively regulated miR-146b expression and increases miR-146b levels in a dose-dependent manner through transcription activation of miR-146b gene. Together, these results suggest a miR-146b regulatory mechanism involving C/EBPβ, which may contribute to the up-regulation of miR-146b in esophageal squamous cell carcinoma.

  16. Beyond standard model searches in the MiniBooNE experiment

    DOE PAGES [OSTI]

    Katori, Teppei; Conrad, Janet M.

    2014-08-05

    Tmore » he MiniBooNE experiment has contributed substantially to beyond standard model searches in the neutrino sector. he experiment was originally designed to test the Δm2~1eV2 region of the sterile neutrino hypothesis by observing νe(ν-e) charged current quasielastic signals from a νμ(ν-μ) beam. MiniBooNE observed excesses of νe and ν-e candidate events in neutrino and antineutrino mode, respectively. o date, these excesses have not been explained within the neutrino standard model (νSM); the standard model extended for three massive neutrinos. Confirmation is required by future experiments such as MicroBooNE. MiniBooNE also provided an opportunity for precision studies of Lorentz violation. he results set strict limits for the first time on several parameters of the standard-model extension, the generic formalism for considering Lorentz violation. Most recently, an extension to MiniBooNE running, with a beam tuned in beam-dump mode, is being performed to search for dark sector particles. In addition, this review describes these studies, demonstrating that short baseline neutrino experiments are rich environments in new physics searches.« less

  17. miR-1297 mediates PTEN expression and contributes to cell progression in LSCC

    SciTech Connect

    Li, Xin; Wang, Hong-liang; Peng, Xin; Zhou, Hui-fang; Wang, Xin

    2012-10-19

    Highlights: Black-Right-Pointing-Pointer miR-1297 was found to be overexpressed in LSCC and contribute to the cell progression. Black-Right-Pointing-Pointer PTEN was confirmed to be a target gene of miR-1297. Black-Right-Pointing-Pointer Downregulation of PTEN can rescue the proliferation and invasion ability of miR-1297 downregulated Hep-2 cells. Black-Right-Pointing-Pointer Downregulation of miR-1297 inhibits tumor growth in vivo. -- Abstract: MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression after transcription, and are involved in cancer development. Laryngeal squamous cell carcinoma (LSCC) is one of the most common malignant neoplasms with increasing incidence in recent years. In this paper, we report the overexpression of miR-1297 in LSCC and Hep-2 cells. In addition, PTEN was identified to be directly regulated by miR-1297 through western blot and luciferase activity assay. Furthermore, downregulation of miR-1297 in Hep-2 cells was shown to inhibit cancer cell proliferation, migration, and tumor genesis. Our results document a new epigenetic mechanism for PTEN regulation in LSCC, which is crucial for the development of these tumors.

  18. miR-30a suppresses breast cancer cell proliferation and migration by targeting Eya2

    SciTech Connect

    Fu, Jing; Xu, Xiaojie; Kang, Lei; Zhou, Liying; Wang, Shibin; Lu, Juming; Cheng, Long; Fan, Zhongyi; Yuan, Bin; Tian, Peirong; Zheng, Xiaofei; Yu, Chengze; Ye, Qinong; Lv, Zhaohui

    2014-03-07

    Highlights: • miR-30a represses Eya2 expression by binding to the 3′-untranslated region of Eya2. • The miR-30a/EYA2 axis regulates breast cancer cell proliferation and migration. • The miR-30a/EYA2 axis modulates G1/S cell cycle progression. • The miR-30a/EYA2 axis is dysregulated in breast cancer patients. - Abstract: Eye absent (Eya) proteins are involved in cell fate determination in a broad spectrum of cells and tissues. Aberrant expression of Eya2 has been documented in a variety of cancers and correlates with clinical outcome. However, whether microRNAs (miRNAs) can regulate Eya2 expression remains unknown. Here, we show that miR-30a represses Eya2 expression by binding to the 3′-untranslated region of Eya2. Overexpression of Eya2 in miR-30a-transfected breast cancer cells effectively rescued the inhibition of cell proliferation and migration caused by miR-30a. Knockdown of Eya2 by small-interfering RNA (siRNA) in breast cancer cells mimicked the effect induced by miR-30a and abolished the ability of miR-30a to regulate breast cancer cell proliferation and migration. The miR-30a/Eya2 axis could regulate G1/S cell cycle progression, accompanied by the modulation of expression of cell cycle-related proteins, including cyclin A, cyclin D1, cyclin E, and c-Myc. Moreover, miR-30a expression was downregulated in breast cancer patients, and negatively correlated with Eya2, which was upregulated in breast cancer patients. These data suggest that the miR-30a/Eya2 axis may play an important role in breast cancer development and progression and that miR-30a activation or Eya2 inhibition may be a useful strategy for cancer treatment.

  19. Application for Presidential Permit OE Docket No. PP-400 TDI-NE New England Clean Power Link Project

    Energy.gov [DOE]

    Response for TDI-NE from Department of Defense to construct, operate, and maintain electric transmission facilities at the U.S. - Canada Border.

  20. Charged-Current Neutral Pion production at SciBooNE

    SciTech Connect

    Catala-Perez, J.; /Valencia U., IFIC

    2009-10-01

    SciBooNE, located in the Booster Neutrino Beam at Fermilab, collected data from June 2007 to August 2008 to accurately measure muon neutrino and anti-neutrino cross sections on carbon below 1 GeV neutrino energy. SciBooNE is studying charged current interactions. Among them, neutral pion production interactions will be the focus of this poster. The experimental signature of neutrino-induced neutral pion production is constituted by two electromagnetic cascades initiated by the conversion of the {pi}{sup 0} decay photons, with an additional muon in the final state for CC processes. In this poster, I will present how we reconstruct and select charged-current muon neutrino interactions producing {pi}{sup 0}'s in SciBooNE.

  1. miR-21 modulates resistance of HR-HPV positive cervical cancer cells to radiation through targeting LATS1

    SciTech Connect

    Liu, Shikai; Song, Lili Zhang, Liang; Zeng, Saitian; Gao, Fangyuan

    2015-04-17

    Although multiple miRNAs are found involved in radioresistance development in HR-HPV positive (+) cervical cancer, only limited studies explored the regulative mechanism of the miRNAs. miR-21 is one of the miRNAs significantly upregulated in HR-HPV (+) cervical cancer is also significantly associated with radioresistance. However, the detailed regulative network of miR-21 in radioresistance is still not clear. In this study, we confirmed that miR-21 overexpression was associated with higher level of radioresistance in HR-HPV (+) cervical cancer patients and thus decided to further explore its role. Findings of this study found miR-21 can negatively affect radiosensitivity of HR-HPV (+) cervical cancer cells and decrease radiation induced G2/M block and increase S phase accumulation. By using dual luciferase assay, we verified a binding site between miR-21 and 3′-UTR of large tumor suppressor kinase 1 (LATS1). Through direct binding, miR-21 can regulate LATS1 expression in cervical cancer cells. LATS1 overexpression can reverse miR-21 induced higher colony formation rate and also reduced miR-21 induced S phase accumulation and G2/M phase block reduction under radiation treatment. These results suggested that miR-21-LATS1 axis plays an important role in regulating radiosensitivity. - Highlights: • miR-21 is highly expressed in HR-HPV (+) radioresistant cervical cancer patients. • miR-21 can negatively affect radiosensitivity of HR-HPV (+) cervical cancer cells. • miR-21 can decrease radiation induced G2/M block and increase S phase accumulation. • miR-21 modulates radiosensitivity cervical cancer cell by directly targeting LATS1.

  2. miR-92a is upregulated in cervical cancer and promotes cell proliferation and invasion by targeting FBXW7

    SciTech Connect

    Zhou, Chuanyi; Shen, Liangfang; Mao, Lei; Wang, Bing; Li, Yang; Yu, Huizhi

    2015-02-27

    MicroRNAs (miRNAs) are involved in the cervical carcinogenesis and progression. In this study, we investigated the role of miR-92a in progression and invasion of cervical cancer. MiR-92a was significantly upregulated in cervical cancer tissues and cell lines. Overexpression of miR-92a led to remarkably enhanced proliferation by promoting cell cycle transition from G1 to S phase and significantly enhanced invasion of cervical cancer cells, while its knockdown significantly reversed these cellular events. Bioinformatics analysis suggested F-box and WD repeat domain-containing 7 (FBXW7) as a novel target of miR-92a, and miR-92a suppressed the expression level of FBXW7 mRNA by direct binding to its 3′-untranslated region (3′UTR). Expression of miR-92a was negatively correlated with FBXW7 in cervical cancer tissues. Furthermore, Silencing of FBXW7 counteracted the effects of miR-92a suppression, while its overexpression reversed oncogenic effects of miR-92a. Together, these findings indicate that miR-92a acts as an onco-miRNA and may contribute to the progression and invasion of cervical cancer, suggesting miR-92a as a potential novel diagnostic and therapeutic target of cervical cancer. - Highlights: • miR-92a is elevated in cervical cancer tissues and cell lines. • miR-92a promotes cervical cancer cell proliferation, cell cycle transition from G1 to S phase and invasion. • FBXW7 is a direct target of miR-92a. • FBXW7 counteracts the oncogenic effects of miR-92a on cervical cancer cells.

  3. Marysville, MI Natural Gas Pipeline Imports From Canada (Million Cubic

    Energy Information Administration (EIA) (indexed site)

    Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 10 1,827 135 2000's NA NA 74 0 303 0 24 876 2,252 5,651 2010's 5,694 9,946 8,099 2,337 4,650 1,961 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Natural Gas Pipeline Imports by Point of Entry Marysville, MI Natural Gas Imports by Pipeli

  4. Marysville, MI Natural Gas Pipeline Imports From Canada (Dollars per

    Energy Information Administration (EIA) (indexed site)

    Thousand Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 3.48 2.17 2.06 2000's NA NA 3.95 -- 7.80 -- 7.07 7.59 8.59 3.80 2010's 4.44 4.42 2.99 4.15 6.86 2.73 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Price of Natural Gas Pipeline Imports by Point of Entry Marysville, MI Natural Gas

  5. NuMI proton kicker extraction magnet termination resistor system

    SciTech Connect

    Reeves, S.R.; Jensen, C.C.; /Fermilab

    2005-05-01

    The temperature stability of the kicker magnet termination resistor assembly directly affects the field flatness and amplitude stability. Comprehensive thermal enhancements were made to the existing Main Injector resistor assembly design to satisfy NuMI performance specifications. Additionally, a fluid-processing system utilizing Fluorinert{reg_sign} FC-77 high-voltage dielectric was built to precisely control the setpoint temperature of the resistor assembly from 70 to 120F, required to maintain constant resistance during changing operational modes. The Fluorinert{reg_sign} must be continually processed to remove hazardous breakdown products caused by radiation exposure to prevent chemical attack of system components. Design details of the termination resistor assembly and Fluorinert{reg_sign} processing system are described. Early performance results will be presented.

  6. Non-canonical microRNAs miR-320 and miR-702 promote proliferation in Dgcr8-deficient embryonic stem cells

    SciTech Connect

    Kim, Byeong-Moo; Choi, Michael Y.

    2012-09-21

    Highlights: Black-Right-Pointing-Pointer Embryonic stem cells (ESCs) lacking non-canonical miRNAs proliferate slower. Black-Right-Pointing-Pointer miR-320 and miR-702 are two non-canonical miRNAs expressed in ESCs. Black-Right-Pointing-Pointer miR-320 and miR-702 promote proliferation of Dgcr8-deficient ESCs. Black-Right-Pointing-Pointer miR-320 targets p57 and helps to release Dgcr8-deficient ESCs from G1 arrest. Black-Right-Pointing-Pointer miR-702 targets p21 and helps to release Dgcr8-deficient ESCs from G1 arrest. -- Abstract: MicroRNAs are known to contribute significantly to stem cell phenotype by post-transcriptionally regulating gene expression. Most of our knowledge of microRNAs comes from the study of canonical microRNAs that require two sequential cleavages by the Drosha/Dgcr8 heterodimer and Dicer to generate mature products. In contrast, non-canonical microRNAs bypass the cleavage by the Drosha/Dgcr8 heterodimer within the nucleus but still require cytoplasmic cleavage by Dicer. The function of non-canonical microRNAs in embryonic stem cells (ESCs) remains obscure. It has been hypothesized that non-canonical microRNAs have important roles in ESCs based upon the phenotypes of ESC lines that lack these specific classes of microRNAs; Dicer-deficient ESCs lacking both canonical and non-canonical microRNAs have much more severe proliferation defect than Dgcr8-deficient ESCs lacking only canonical microRNAs. Using these cell lines, we identified two non-canonical microRNAs, miR-320 and miR-702, that promote proliferation of Dgcr8-deficient ESCs by releasing them from G1 arrest. This is accomplished by targeting the 3 Prime -untranslated regions of the cell cycle inhibitors p57 and p21 and thereby inhibiting their expression. This is the first report of the crucial role of non-canonical microRNAs in ESCs.

  7. miR-182 targets CHL1 and controls tumor growth and invasion in papillary thyroid carcinoma

    SciTech Connect

    Zhu, Hongling; Fang, Jin; Zhang, Jichen; Zhao, Zefei; Liu, Lianyong; Wang, Jingnan; Xi, Qian; Gu, Mingjun

    2014-07-18

    Highlights: miR-182 and CHL1 expression patterns are negatively correlated. CHL1 is a direct target of miR-182 in PTC cells. miR-182 suppression inhibits PTC cell growth and invasion. CHL1 is involved in miR-182-mediated cell behavior. - Abstract: In this study, we investigated the role and underlying mechanism of action of miR-182 in papillary thyroid carcinoma (PTC). Bioinformatics analysis revealed close homolog of LI (CHL1) as a potential target of miR-182. Upregulation of miR-182 was significantly correlated with CHL1 downregulation in human PTC tissues and cell lines. miR-182 suppressed the expression of CHL1 mRNA through direct targeting of the 3?-untranslated region (3?-UTR). Downregulation of miR-182 suppressed growth and invasion of PTC cells. Silencing of CHL1 counteracted the effects of miR-182 suppression, while its overexpression mimicked these effects. Our data collectively indicate that miR-182 in PTC promotes cell proliferation and invasion through direct suppression of CHL1, supporting the potential utility of miR-182 inhibition as a novel therapeutic strategy against PTC.

  8. Microsoft PowerPoint - Oxford_MiniBooNE_and_SterileNus.ppt

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Oxford Seminar June 23, 2004 * Extensions to the Neutrino Standard Model: Sterile Neutrinos * MiniBooNE: Status and Prospects * Future Directions if MiniBooNE Sees Oscillations 2 Theoretical Prejudices before 1995 * Natural scale for ∆m 2 ~ 10 - 100 eV 2 since needed to explain dark matter * Oscillation mixing angles must be small like the quark mixing angles * Solar neutrino oscillations must be small mixing angle MSW solution because it is "cool" * Atmospheric neutrino anomaly must

  9. NE-23 Disposal of Offsite-Generated Defense Radioactive Waste, Ventron

    Office of Legacy Management (LM)

    pi/L +3 *3L 52. NE-23 Disposal of Offsite-Generated Defense Radioactive Waste, Ventron FUSRAP Site Jill E. Lytle, DP-12 NE-23 The Office of Remedial Action and Waste Technology has received a request from the Technical Services Division, DOE-Oak Ridge Operations Office, for a determination of the appropriate disposal location for the material which will result from remedial action of the Ventron site in Beverly, Massachusetts. The Ventron site was used from 1942 to 1948 under contract to the ME0

  10. MiniBooNE Charged Current Charged Pion Cross Section Data Release

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Muon Neutrino-Induced Charged-Current Charged Pion Production Cross Sections on Mineral Oil at Enu~1 GeV", arXiv:1011.3572 [hep-ex], submitted to Phys. Rev. D. The following MiniBooNE information for the 2010 CC π+ cross section paper is made available to the public. Tables A root file containing histograms of all of the cross section results in the paper can be found here. A text file of the cross section results can be found here. The MiniBooNE muon neutrino flux distribution can be

  11. MiniBooNE Neutral Current Elastic Cross Section Data Release

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    the Neutrino Neutral-Current Elastic Differential Cross Section",arXiv:1007.4730 [hep-ex], Phys. Rev. D82, 092005 (2010) The following MiniBooNE information for the 2010 neutral current elastic cross section paper is made available to the public. MiniBooNE neutral current elastic cross-section results in the "paper" are reported in the true energy after the unsmearing of detector resolution and efficiency effects. In addition, here we present alternative results in the

  12. MiniBooNE as related to Windows on the Universe

    SciTech Connect

    Stefanski, Ray; /Fermilab

    2009-12-01

    The measurement of absolute neutrino and anti-neutrino cross-sections, the observation of a 'low energy anomaly' in the neutrino sector, the constraints placed on the LSND effect by a non-observation of neutrino oscillations, the search for neutrino and anti-neutrino appearance, and for the possible existence of new heavy particles makes MiniBooNE a major contributor to the current view of the Universe. This paper addresses specific model constraints set by the MiniBooNE data, and explores expectations for further remaining analysis of the data.

  13. Numerical Analysis of Parasitic Crossing Compensation with Wires in DA$\\Phi$NE

    SciTech Connect

    Valishev, A.; Shatilov, D.; Milardi, C.; Zobov, M.

    2015-06-24

    Current-bearing wire compensators were successfully used in the 2005-2006 run of the DAΦNE collider to mitigate the detrimental effects of parasitic beam-beam interactions. A marked improvement of the positron beam lifetime was observed in machine operation with the KLOE detector. In view of the possible application of wire beam-beam compensators for the High Luminosity LHC upgrade, we revisit the DAΦNE experiments. We use an improved model of the accelerator with the goal to validate the modern simulation tools and provide valuable input for the LHC upgrade project.

  14. Downregulation of miRNA-30c and miR-203a is associated with hepatitis C virus core protein-induced epithelial–mesenchymal transition in normal hepatocytes and hepatocellular carcinoma cells

    SciTech Connect

    Liu, Dongjing; Wu, Jilin; Liu, Meizhou; Yin, Hui; He, Jiantai; Zhang, Bo

    2015-09-04

    Hepatitis C virus (HCV) Core protein has been demonstrated to induce epithelial–mesenchymal transition (EMT) and is associated with cancer progression of hepatocellular carcinoma (HCC). However, how the Core protein regulates EMT is still unclear. In this study, HCV Core protein was overexpressed by an adenovirus. The protein levels of EMT markers were measured by Western blot. The xenograft animal model was established by inoculation of HepG2 cells. Results showed that ectopic expression of HCV core protein induced EMT in L02 hepatocytes and HepG2 tumor cells by upregulating vimentin, Sanl1, and Snal2 expression and downregulating E-cadherin expression. Moreover, Core protein downregulated miR-30c and miR-203a levels in L02 and HepG2 cells, but artificial expression of miR-30c and miR-203a reversed Core protein-induced EMT. Further analysis showed that ectopic expression of HCV core protein stimulated cell proliferation, inhibited apoptosis, and increased cell migration, whereas artificial expression of miR-30c and miR-203a significantly reversed the role of Core protein in these cell functions in L02 and HepG2 cells. In the HepG2 xenograft tumor models, artificial expression of miR-30c and miR-203a inhibited EMT and tumor growth. Moreover, L02 cells overexpressing Core protein can form tumors in nude mice. In HCC patients, HCV infection significantly shortened patients' survival time, and loss of miR-30c and miR-203 expression correlated with poor survival. In conclusion, HCV core protein downregulates miR-30c and miR-203a expression, which results in activation of EMT in normal hepatocytes and HCC tumor cells. The Core protein-activated-EMT is involved in the carcinogenesis and progression of HCC. Loss of miR-30c and miR-203a expression is a marker for the poor prognosis of HCC. - Highlights: • HCV core protein downregulates miR-30c and miR-203a expression. • Downregulation of miR-30c and miR-203a activates EMT. • Activated-EMT is involved in the

  15. miR-128 and its target genes in tumorigenesis and metastasis

    SciTech Connect

    Li, Molin, E-mail: molin_li@hotmail.com [Dalian Medical University, Dalian 116044 (China); Fu, Weiming [Center for Food Safety and Environmental Technology, Guangzhou Institute of Advanced Technology, Chinese Academy of Sciences, Guangzhou 511458 (China); Wo, Lulu; Shu, Xiaohong [Dalian Medical University, Dalian 116044 (China); Liu, Fang [The second affiliated hospital of Dalian Medical University, Dalian 116023 (China); Li, Chuangang, E-mail: li_chuangang@sina.com [The second affiliated hospital of Dalian Medical University, Dalian 116023 (China)

    2013-12-10

    MicroRNAs (miRNAs) are a class of endogenous, non-coding, 1824 nucleotide length single-strand RNAs that could modulate gene expression at post-transcriptional level. Previous studies have shown that miR-128 enriched in the brain plays an important role in the development of nervous system and the maintenance of normal physical functions. Aberrant expression of miR-128 has been detected in many types of human tumors and its validated target genes are involved in cancer-related biological processes such as cell proliferation, differentiation and apoptosis. In this review, we will summarize the roles of miR-128 and its target genes in tumorigenesis and metastasis. - Highlights: Aberrant expression of miR-128 can be observed in many kinds of malignant tumors. The molecular mechanisms regulating miR-128 expression are elucidated. Roles of miR-128 and its target genes in tumorigenesis and metastasis are summarized.

  16. miR-125b inhibits osteoblastic differentiation by down-regulation of cell proliferation

    SciTech Connect

    Mizuno, Yosuke; Yagi, Ken; Tokuzawa, Yoshimi; Kanesaki-Yatsuka, Yukiko; Suda, Tatsuo; Katagiri, Takenobu; Fukuda, Toru; Maruyama, Masayoshi; Okuda, Akihiko; Amemiya, Tomoyuki; Kondoh, Yasumitsu; Tashiro, Hideo; Okazaki, Yasushi

    2008-04-04

    Although various microRNAs regulate cell differentiation and proliferation, no miRNA has been reported so far to play an important role in the regulation of osteoblast differentiation. Here we describe the role of miR-125b in osteoblastic differentiation in mouse mesenchymal stem cells, ST2, by regulating cell proliferation. The expression of miR-125b was time-dependently increased in ST2 cells, and the increase in miR-125b expression was attenuated in osteoblastic-differentiated ST2 cells induced by BMP-4. The transfection of exogenous miR-125b inhibited proliferation of ST2 cells and caused inhibition of osteoblastic differentiation. In contrast, when the endogenous miR-125b was blocked by transfection of its antisense RNA molecule, alkaline phosphatase activity after BMP-4 treatment was elevated. These results strongly suggest that miR-125b is involved in osteoblastic differentiation through the regulation of cell proliferation.

  17. miR-15a/16 Enhances Radiation Sensitivity of Non-Small Cell Lung Cancer

    Office of Scientific and Technical Information (OSTI)

    Cells by Targeting the TLR1/NF-κB Signaling Pathway (Journal Article) | SciTech Connect miR-15a/16 Enhances Radiation Sensitivity of Non-Small Cell Lung Cancer Cells by Targeting the TLR1/NF-κB Signaling Pathway Citation Details In-Document Search Title: miR-15a/16 Enhances Radiation Sensitivity of Non-Small Cell Lung Cancer Cells by Targeting the TLR1/NF-κB Signaling Pathway Purpose: Many miRNAs have been identified as essential issues and core determining factors in tumor radiation.

  18. Simulation of Crab Waist Collisions In DA$\\Phi$NE With KLOE-2 Interaction Region

    SciTech Connect

    Zobov, M.; Drago, A.; Gallo, A.; Milardi, C.; Shatilov, D.; Valishev, A.

    2015-06-24

    After the successful completion of the SIDDHARTA experiment run with crab waist collisions, the electron-positron collider DAΦNE has started routine operations for the KLOE-2 detector. The new interaction region also exploits the crab waist collision scheme, but features certain complications including the experimental detector solenoid, compensating anti-solenoids, and tilted quadrupole magnets. We have performed simulations of the beam-beam collisions in the collider taking into account the real DAΦNE nonlinear lattice. In particular, we have evaluated the effect of crab waist sextupoles and beam-beam interactions on the DAΦNE dynamical aperture and energy acceptance, and estimated the luminosity that can be potentially achieved with and without crab waist sextupoles in the present working conditions. A numerical analysis has been performed in order to propose possible steps for further luminosity increase in DAΦNE such as a better working point choice, crab sextupole strength optimization, correction of the phase advance between the sextupoles and the interaction region. The proposed change of the e- ring working point was implemented and resulted in a significant performance increase.

  19. Overexpression of miR-206 suppresses glycolysis, proliferation and migration in breast cancer cells via PFKFB3 targeting

    SciTech Connect

    Ge, Xin; Lyu, Pengwei; Cao, Zhang; Li, Jingruo; Guo, Guangcheng; Xia, Wanjun; Gu, Yuanting

    2015-08-07

    miRNAs, sorting as non-coding RNAs, are differentially expressed in breast tumor and act as tumor promoters or suppressors. miR-206 could suppress the progression of breast cancer, the mechanism of which remains unclear. The study here was aimed to investigate the effect of miR-206 on human breast cancers. We found that miR-206 was down-regulated while one of its predicted targets, 6-Phosphofructo-2-kinase (PFKFB3) was up-regulated in human breast carcinomas. 17β-estradiol dose-dependently decreased miR-206 expression as well as enhanced PFKFB3 mRNA and protein expression in estrogen receptor α (ERα) positive breast cancer cells. Furthermore, we identified that miR-206 directly interacted with 3′-untranslated region (UTR) of PFKFB3 mRNA. miR-206 modulated PFKFB3 expression in MCF-7, T47D and SUM159 cells, which was influenced by 17β-estradiol depending on ERα expression. In addition, miR-206 overexpression impeded fructose-2,6-bisphosphate (F2,6BP) production, diminished lactate generation and reduced cell proliferation and migration in breast cancer cells. In conclusion, our study demonstrated that miR-206 regulated PFKFB3 expression in breast cancer cells, thereby stunting glycolysis, cell proliferation and migration. - Highlights: • miR-206 was down-regulated and PFKFB3 was up-regulated in human breast carcinomas. • 17β-estradiol regulated miR-206 and PFKFB3 expression in ERα+ cancer cells. • miR-206directly interacted with 3′-UTR of PFKFB3 mRNA. • miR-206 fructose-2,6-bisphosphate (F2,6BP) impeded production and lactate generation. • miR-206 reduced cell proliferation and migration in breast cancer cells.

  20. AMENDMENT OF SOLICITATION/MODIFICATlON OF CONTRACT MI54 I See...

    National Nuclear Security Administration (NNSA)

    MI54 I See Block 16C I REQ. NO. Babcock & Wilcox Technical Services Pantex, LLC PO Box 30020 Amarillo, TX 79120 2. AMENDMENTIMODIFICATION NO. 1 3. EFFECTIVE DATE 1 4. ...

  1. File:USDA-CE-Production-GIFmaps-MI.pdf | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    MI.pdf Jump to: navigation, search File File history File usage Michigan Ethanol Plant Locations Size of this preview: 463 599 pixels. Other resolution: 464 600 pixels. Full...

  2. Simulations of neutron multiplicity measurements with MCNP-PoliMi.

    SciTech Connect

    Mattingly, John K.; Pozzi, Sara A.; Clarke, Shaun D.; Dennis, Ben D.; Miller, Eric C.

    2010-09-01

    The heightened focus on nuclear safeguards and accountability has increased the need to develop and verify simulation tools for modeling these applications. The ability to accurately simulate safeguards techniques, such as neutron multiplicity counting, aids in the design and development of future systems. This work focuses on validating the ability of the Monte Carlo code MCNPX-PoliMi to reproduce measured neutron multiplicity results for a highly multiplicative sample. The benchmark experiment for this validation consists of a 4.5-kg sphere of plutonium metal that was moderated by various thicknesses of polyethylene. The detector system was the nPod, which contains a bank of 15 3He detectors. Simulations of the experiments were compared to the actual measurements and several sources of potential bias in the simulation were evaluated. The analysis included the effects of detector dead time, source-detector distance, density, and adjustments made to the value of {nu}-bar in the data libraries. Based on this analysis it was observed that a 1.14% decrease in the evaluated value of {nu}-bar for 239Pu in the ENDF-VII library substantially improved the accuracy of the simulation.

  3. Climate Action Champions: Sault Ste. Marie Tribe of Chippewa Indians, MI |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Sault Ste. Marie Tribe of Chippewa Indians, MI Climate Action Champions: Sault Ste. Marie Tribe of Chippewa Indians, MI The Sault Ste. Marie Tribe of Chippewa Indians is a 44,000-strong federally recognized Indian tribe that is an economic, social and cultural force in its community across the eastern Upper Peninsula counties of Chippewa, Luce, Mackinac, Schoolcraft, Alger, Delta and Marquette, with housing and tribal centers, casinos, and other enterprises that employ

  4. Strategic Plan for Nuclear Energy -- Knowledge Base for Advanced Modeling and Simulation (NE-KAMS)

    SciTech Connect

    Kimberlyn C. Mousseau

    2011-10-01

    The Nuclear Energy Computational Fluid Dynamics Advanced Modeling and Simulation (NE-CAMS) system is being developed at the Idaho National Laboratory (INL) in collaboration with Bettis Laboratory, Sandia National Laboratory (SNL), Argonne National Laboratory (ANL), Utah State University (USU), and other interested parties with the objective of developing and implementing a comprehensive and readily accessible data and information management system for computational fluid dynamics (CFD) verification and validation (V&V) in support of nuclear energy systems design and safety analysis. The two key objectives of the NE-CAMS effort are to identify, collect, assess, store and maintain high resolution and high quality experimental data and related expert knowledge (metadata) for use in CFD V&V assessments specific to the nuclear energy field and to establish a working relationship with the U.S. Nuclear Regulatory Commission (NRC) to develop a CFD V&V database, including benchmark cases, that addresses and supports the associated NRC regulations and policies on the use of CFD analysis. In particular, the NE-CAMS system will support the Department of Energy Office of Nuclear Energy Advanced Modeling and Simulation (NEAMS) Program, which aims to develop and deploy advanced modeling and simulation methods and computational tools for reliable numerical simulation of nuclear reactor systems for design and safety analysis. Primary NE-CAMS Elements There are four primary elements of the NE-CAMS knowledge base designed to support computer modeling and simulation in the nuclear energy arena as listed below. Element 1. The database will contain experimental data that can be used for CFD validation that is relevant to nuclear reactor and plant processes, particularly those important to the nuclear industry and the NRC. Element 2. Qualification standards for data evaluation and classification will be incorporated and applied such that validation data sets will result in well

  5. Microsoft PowerPoint - NOW2004_MiniBooNE.ppt

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    NOW2004 Workshop * Extensions to the Neutrino Standard Model: Sterile Neutrinos * MiniBooNE: Status and Prospects * Future Directions if MiniBooNE Sees Oscillations 2 Three Signal Regions * LSND ∆m 2 = 0.1 - 10 eV 2 , small mixing * Atmospheric ∆m 2 = 2.5×10 -3 eV 2 , large mixing * Solar ∆m 2 = 8.2×10 -5 eV 2 , large mixing ∆m 13 ∆m 12 ∆m 23 2 2 2 ( ) 1 sin 2 sin (1.27 / ) P m L E α α ν ν θ → = - ∆ 2 2 2 2 2 2 21 32 31 Three distinct neutrino oscillation signals, with For

  6. miR-196a targets netrin 4 and regulates cell proliferation and migration of cervical cancer cells

    SciTech Connect

    Zhang, Jie; Zheng, Fangxia; Yu, Gang; Yin, Yanhua; Lu, Qingyang

    2013-11-01

    Highlights: miR-196a was overexpressed in cervical cancer tissue compared to normal tissue. miR-196a expression elevated proliferation and migration of cervical cancer cells. miR-196a inhibited NTN4 expression by binding 3?-UTR region of NTN4 mRNA. NTN4 inversely correlated with miR-196a expression in cervical tissue and cell line. NTN4 expression was low in cervical cancer tissue compared to normal tissue. -- Abstract: Recent research has uncovered tumor-suppressive and oncogenic potential of miR-196a in various tumors. However, the expression and mechanism of its function in cervical cancer remains unclear. In this study, we assess relative expression of miR-196a in cervical premalignant lesions, cervical cancer tissues, and four cancer cell lines using quantitative real-time PCR. CaSki and HeLa cells were treated with miR-196a inhibitors, mimics, or pCDNA/miR-196a to investigate the role of miR-196a in cancer cell proliferation and migration. We demonstrated that miR-196a was overexpressed in cervical intraepithelial neoplasia 23 and cervical cancer tissue. Moreover, its expression contributes to the proliferation and migration of cervical cancer cells, whereas inhibiting its expression led to a reduction in proliferation and migration. Five candidate targets of miR-196a chosen by computational prediction and Cervical Cancer Gene Database search were measured for their mRNA in both miR-196a-overexpressing and -depleted cancer cells. Only netrin 4 (NTN4) expression displayed an inverse association with miR-196a. Fluorescent reporter assays revealed that miR-196a inhibited NTN4 expression by targeting one binding site in the 3?-untranslated region (3?-UTR) of NTN4 mRNA. Furthermore, qPCR and Western blot assays verified NTN4 expression was downregulated in cervical cancer tissues compared to normal controls, and in vivo mRNA level of NTN4 inversely correlated with miR-196a expression. In summary, our findings provide new insights about the functional role of

  7. Application for Presidential Permit OE Docket No. PP-400 TDI-NE - New

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    England Clean Power Link Project - Comments and Motion to Intervene of Conservation Law Foundation | Department of Energy - New England Clean Power Link Project - Comments and Motion to Intervene of Conservation Law Foundation Application for Presidential Permit OE Docket No. PP-400 TDI-NE - New England Clean Power Link Project - Comments and Motion to Intervene of Conservation Law Foundation Conservation Law Foundation (CLF) provides the following comments and Motion to Intervene regarding

  8. Application for Presidential Permit OE Docket No. PP-400 TDI-NE - New

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    England Clean Power Link Project: Comments and Motion to Intervene Out of Time of Allco Renewable Energy Limited | Department of Energy - New England Clean Power Link Project: Comments and Motion to Intervene Out of Time of Allco Renewable Energy Limited Application for Presidential Permit OE Docket No. PP-400 TDI-NE - New England Clean Power Link Project: Comments and Motion to Intervene Out of Time of Allco Renewable Energy Limited ALLCO Renewable Energy Limited provides the following

  9. Application for Presidential Permit OE Docket No. PP-400 TDI-NE - New

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    England Clean Power Link Project: Motion to Intervene of The Northeast Power Coordinating Council, Inc. | Department of Energy Project: Motion to Intervene of The Northeast Power Coordinating Council, Inc. Application for Presidential Permit OE Docket No. PP-400 TDI-NE - New England Clean Power Link Project: Motion to Intervene of The Northeast Power Coordinating Council, Inc. Northeast Power Coordinating Council, Inc. (NPCC) submits its Motion to Intervene the New England Clean Power Link

  10. Application for Presidential Permit OE Docket No. PP-400 TDI-NE New England

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Clean Power Link Project: Notice of Intent to Prepare an Environmental Impact Statement: Federal Register Notice, Volume 79, No. 165, August 26, 2014 | Department of Energy New England Clean Power Link Project: Notice of Intent to Prepare an Environmental Impact Statement: Federal Register Notice, Volume 79, No. 165, August 26, 2014 Application for Presidential Permit OE Docket No. PP-400 TDI-NE New England Clean Power Link Project: Notice of Intent to Prepare an Environmental Impact

  11. Measuring n-N Deep Inelastic Cross Sections at MiniBooNE

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    + Cross Section Results from MiniBooNE Mike Wilking TRIUMF / University of Colorado NuInt 22 May 2009 CCπ + in Oscillation Experiments  The next generation of ν oscillation experiments lie at low, mostly unexplored ν energies  CCQE is the signal process for oscillation measurements  At these energies, CCπ + is the dominant charged-current background T2K NOνA CCπ + CCQE DIS Charged Current Cross Sections Previous CCπ + Measurements  The plot shows previous absolute cross

  12. NE-23 Elimination of the Chupadera Mesa and Los Alamos County Industrial Waste

    Office of Legacy Management (LM)

    AM? 2 2 1986 NE-23 Elimination of the Chupadera Mesa and Los Alamos County Industrial Waste Line Sites from Further Consideration for FUSRAP Inclusion Carlos E. Garcia, Director Environmental Safety and Health Division Albuquerque Operations Office The enclosed material is being provided to you to document the final actions taken under the Department's Formerly Utilized Sites Remedial Action Program (FUSRAP) for the Chupadera Mesa area and the Los Alamos County Industrial Waste Lines, New

  13. Microsoft PowerPoint - 2016_DOE-NE Cross-cut Coordination Meeting.pptx

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Nuclear Graphite Research Needs Will Windes Idaho National Laboratory DOE-NE NEET Cross-cut Coordination Meeting August 15-16, 2016 Department of Energy (DOE) Advanced Reactor Technologies (ART) R&D Program Why Research Graphite?  Lessons we've learned from other graphite core reactor programs - After Reactor Start-up... * Interestingly - fuel is not considered life limiting component after start-up * Graphite is life limiting component of reactor - Degradation issues of graphite - normal

  14. Microsoft Word - MicroBooNE CD-1 appr.docx

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    1 Approve Alternative Selection and Cost Range of the Large Liquid Argon Detector for Neutrino Physics (MicroBooNE) Project at the Fermi National Accelerator Laboratory Office of High Energy Physics Office of Science Purpose The purpose of this paper is to document the review and approval by the Office of Science Energy Systems Acquisition Advisory Board-equivalent for Critical Decision 1 (CD-1) "Approve Alternative Selection and Cost Range" for the Large Liquid Argon Detector for

  15. Possible shape coexistence and magnetic dipole transitions in {sup 17}C and {sup 21}Ne

    SciTech Connect

    Sagawa, H.; Zhou, X. R.; Suzuki, Toshio; Yoshida, N.

    2008-10-15

    Magnetic dipole (M1) transitions of N=11 nuclei {sup 17}C and {sup 21}Ne are investigated by using shell model and deformed Skyrme Hartree-Fock + blocked BCS wave functions. Shell model calculations predict well observed energy spectra and magnetic dipole transitions in {sup 21}Ne, while the results are rather poor to predict these observables in {sup 17}C. In the deformed HF calculations, the ground states of the two nuclei are shown to have large prolate deformations close to {beta}{sub 2}=0.4. It is also pointed out that the first K{sup {pi}}=1/2{sup +} state in {sup 21}Ne is prolately deformed, while the first K{sup {pi}}=1/2{sup +} state in {sup 17}C is predicted to have a large oblate deformation close to the ground state in energy, We point out that the experimentally observed large hindrance of the M1 transition between I{sup {pi}}=1/2{sup +} and 3/2{sup +} in {sup 17}C can be attributed to a shape coexistence near the ground state of {sup 17}C.

  16. MCViNE- An object oriented Monte Carlo neutron ray tracing simulation package

    DOE PAGES [OSTI]

    Lin, J. Y. Y.; Smith, Hillary L.; Granroth, Garrett E.; Abernathy, Douglas L.; Lumsden, Mark D.; Winn, Barry L.; Aczel, Adam A.; Aivazis, Michael; Fultz, Brent

    2015-11-28

    MCViNE (Monte-Carlo VIrtual Neutron Experiment) is an open-source Monte Carlo (MC) neutron ray-tracing software for performing computer modeling and simulations that mirror real neutron scattering experiments. We exploited the close similarity between how instrument components are designed and operated and how such components can be modeled in software. For example we used object oriented programming concepts for representing neutron scatterers and detector systems, and recursive algorithms for implementing multiple scattering. Combining these features together in MCViNE allows one to handle sophisticated neutron scattering problems in modern instruments, including, for example, neutron detection by complex detector systems, and single and multiplemore » scattering events in a variety of samples and sample environments. In addition, MCViNE can use simulation components from linear-chain-based MC ray tracing packages which facilitates porting instrument models from those codes. Furthermore it allows for components written solely in Python, which expedites prototyping of new components. These developments have enabled detailed simulations of neutron scattering experiments, with non-trivial samples, for time-of-flight inelastic instruments at the Spallation Neutron Source. Examples of such simulations for powder and single-crystal samples with various scattering kernels, including kernels for phonon and magnon scattering, are presented. As a result, with simulations that closely reproduce experimental results, scattering mechanisms can be turned on and off to determine how they contribute to the measured scattering intensities, improving our understanding of the underlying physics.« less

  17. Comparison of GiBUU calculations with MiniBooNE pion production data

    SciTech Connect

    Lalakulich, O.; Mosel, U.

    2015-05-15

    Background: Neutrino-induced pion production can give important informationon the axial coupling to nucleon resonances. Furthermore, pion production represents a major background to quasielastic-like events. one pion production data from the MiniBooNE in charged current neutrino scattering in mineral oil appeared higher than expected within conventional theoretical approaches. Purpose: We aim to investigate which model parameters affect the calculated cross section and how they do this. Method: The Giessen Boltzmann–Uehling–Uhlenbeck (GiBUU) model is used for an investigation of neutrino-nucleus reactions. Results: Presented are integrated and differential cross sections for 1π{sup +} and 1π{sup 0} production before and after final state interactions in comparison with the MiniBooNE data. Conclusions: For the MiniBooNE flux all processes (QE, 1π-background, Δ, higher resonance production, DIS) contribute to the observed final state with one pion of a given charge. The uncertainty in elementary pion production cross sections leads to a corresponding uncertainty in the nuclear cross sections. Final state interactions change the shape of the muon-related observables only slightly, but they significantly change the shape of pion distributions.

  18. MCViNE- An object oriented Monte Carlo neutron ray tracing simulation package

    SciTech Connect

    Lin, J. Y. Y.; Smith, Hillary L.; Granroth, Garrett E.; Abernathy, Douglas L.; Lumsden, Mark D.; Winn, Barry L.; Aczel, Adam A.; Aivazis, Michael; Fultz, Brent

    2015-11-28

    MCViNE (Monte-Carlo VIrtual Neutron Experiment) is an open-source Monte Carlo (MC) neutron ray-tracing software for performing computer modeling and simulations that mirror real neutron scattering experiments. We exploited the close similarity between how instrument components are designed and operated and how such components can be modeled in software. For example we used object oriented programming concepts for representing neutron scatterers and detector systems, and recursive algorithms for implementing multiple scattering. Combining these features together in MCViNE allows one to handle sophisticated neutron scattering problems in modern instruments, including, for example, neutron detection by complex detector systems, and single and multiple scattering events in a variety of samples and sample environments. In addition, MCViNE can use simulation components from linear-chain-based MC ray tracing packages which facilitates porting instrument models from those codes. Furthermore it allows for components written solely in Python, which expedites prototyping of new components. These developments have enabled detailed simulations of neutron scattering experiments, with non-trivial samples, for time-of-flight inelastic instruments at the Spallation Neutron Source. Examples of such simulations for powder and single-crystal samples with various scattering kernels, including kernels for phonon and magnon scattering, are presented. As a result, with simulations that closely reproduce experimental results, scattering mechanisms can be turned on and off to determine how they contribute to the measured scattering intensities, improving our understanding of the underlying physics.

  19. <mi>B> -meson decay constants from 2+1 -flavor lattice QCD with domain-wall light quarks and relativistic heavy quarks

    SciTech Connect

    Christ, N. H.; Flynn, J. M.; Izubuchi, T.; Kawanai, T.; Lehner, C.; Soni, A.; Van de Water, R. S.; Witzel, O.

    2015-03-01

    We calculate the mi>Bmi>-meson decay constants mi>fmi>mi>Bmi>, mi>fmi>mi>Bmi>mi>smi>, and their ratio in unquenched lattice QCD using domain-wall light quarks and relativistic mi>b> quarks. We use gauge-field ensembles generated by the RBC and UKQCD collaborations using the domain-wall fermion action and Iwasaki gauge action with three flavors of light dynamical quarks. We analyze data at two lattice spacings of mi>ami>0.11, 0.086 fm with unitary pion masses as light as mi>Mmi>mi>πmi>290mi>MeV>; this enables us to control the extrapolation to the physical light-quark masses and continuum. For the mi>b> quarks we use the anisotropic clover action with the relativistic heavy-quark interpretation, such that discretization errors from the heavy-quark action are of the same size as from the light-quark sector. We renormalize the

  20. miR-214 promotes the proliferation and invasion of osteosarcoma cells through direct suppression of LZTS1

    SciTech Connect

    Xu, Zhengyu; Wang, Tao

    2014-06-27

    Highlights: • miR-214 is upregulated in human OS tissues and inversely correlated with LZTS1 expression. • miR-214 directly targets LZTS1 by binding to its 3′-UTR. • miR-214 promotes OS cell proliferation, invasion and tumor growth. • Overexpression of LZTS1 reverses miR-214-induced proliferation and invasion of OS cells. - Abstract: Previous studies have shown that miR-214 functions either as an oncogene or a tumor suppressor in various human cancer types. The role of this microRNA in osteosarcoma (OS) is presently unclear. Here, we demonstrated that miR-214 is frequently upregulated in OS specimens, compared with noncancerous bone tissues. Bioinformatics analysis further revealed leucine zipper, putative tumor suppressor 1 (LZTS1) as a potential target of miR-214. Expression patterns of miR-214 were inversely correlated with those of LZTS1 mRNA and protein in OS tissues. Data from reporter assays showed that miR-214 directly binds to the 3′-untranslated region (3′-UTR) of LZTS1 mRNA and suppresses expression at both transcriptional and translational levels. In functional assays, miR-214 promoted OS cell proliferation, invasion and tumor growth in nude mice, which could be reversed by overexpression of LZTS1. Taken together, our data provide compelling evidence that miR-214 functions as an onco-miRNA in OS, and its oncogenic effects are mediated chiefly through downregulation of LZTS1.

  1. MiR-132 prohibits proliferation, invasion, migration, and metastasis in breast cancer by targeting HN1

    SciTech Connect

    Zhang, Zhan-Guo Chen, Wei-Xun Wu, Yan-Hui Liang, Hui-Fang Zhang, Bi-Xiang

    2014-11-07

    Highlights: • MiR-132 is down-regulated in breast cancer tissues and cell lines. • MiR-132 directly regulates HN1 by binding its 3′ UTR. • MiR-132 shows regulatory role in proliferation, invasion, migration and metastasis. • HN1 is involved in miR-132-mediated cell behavior. • Aberrant HN1 is associated with worse overall survival of breast cancer patients. - Abstract: Accumulating evidence indicates that miRNAs play critical roles in tumorigenesis and cancer progression. This study aims to investigate the role and the underlying mechanism of miR-132 in breast cancer. Here, we report that miR-132 is significantly down-regulated in breast cancer tissues and cancer cell lines. Additional study identifies HN1 as a novel direct target of miR-132. MiR-132 down-regulates HN1 expression by binding to the 3′ UTR of HN1 transcript, thereby, suppressing multiple oncogenic traits such as cancer cell proliferation, invasion, migration and metastasis in vivo and in vitro. Overexpression of HN1 restores miR-132-suppressed malignancy. Importantly, higher HN1 expression is significantly associated with worse overall survival of breast cancer patients. Taken together, our data demonstrate a critical role of miR-132 in prohibiting cell proliferation, invasion, migration and metastasis in breast cancer through direct suppression of HN1, supporting the potential utility of miR-132 as a novel therapeutic strategy against breast cancer.

  2. Better Buildings Residential Network Program Sustainability/Working...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    * Ann Arbor, MI * Atlanta, GA * Austin, TX * Boulder, CO * Marquette, MI * Omaha, NE * Opportunity Studies * Superior Watersheds * Clean Energy Coalition (MI) 7152013 ...

  3. Strategic Plan for Nuclear Energy -- Knowledge Base for Advanced Modeling and Simulation (NE-KAMS)

    SciTech Connect

    Rich Johnson; Kimberlyn C. Mousseau; Hyung Lee

    2011-09-01

    NE-KAMS knowledge base will assist computational analysts, physics model developers, experimentalists, nuclear reactor designers, and federal regulators by: (1) Establishing accepted standards, requirements and best practices for V&V and UQ of computational models and simulations, (2) Establishing accepted standards and procedures for qualifying and classifying experimental and numerical benchmark data, (3) Providing readily accessible databases for nuclear energy related experimental and numerical benchmark data that can be used in V&V assessments and computational methods development, (4) Providing a searchable knowledge base of information, documents and data on V&V and UQ, and (5) Providing web-enabled applications, tools and utilities for V&V and UQ activities, data assessment and processing, and information and data searches. From its inception, NE-KAMS will directly support nuclear energy research, development and demonstration programs within the U.S. Department of Energy (DOE), including the Consortium for Advanced Simulation of Light Water Reactors (CASL), the Nuclear Energy Advanced Modeling and Simulation (NEAMS), the Light Water Reactor Sustainability (LWRS), the Small Modular Reactors (SMR), and the Next Generation Nuclear Power Plant (NGNP) programs. These programs all involve computational modeling and simulation (M&S) of nuclear reactor systems, components and processes, and it is envisioned that NE-KAMS will help to coordinate and facilitate collaboration and sharing of resources and expertise for V&V and UQ across these programs. In addition, from the outset, NE-KAMS will support the use of computational M&S in the nuclear industry by developing guidelines and recommended practices aimed at quantifying the uncertainty and assessing the applicability of existing analysis models and methods. The NE-KAMS effort will initially focus on supporting the use of computational fluid dynamics (CFD) and thermal hydraulics (T/H) analysis for M&S of nuclear

  4. miR-421 induces cell proliferation and apoptosis resistance in human nasopharyngeal carcinoma via downregulation of FOXO4

    SciTech Connect

    Chen, Liang; Department of Otolaryngology, Guangzhou General Hospital of PLA Guangzhou Command, Guangzhou 510010 ; Tang, Yanping; Wang, Jian; Yan, Zhongjie; Xu, Ruxiang

    2013-06-14

    Highlights: •miR-421 is upregulated in nasopharyngeal carcinoma. •miR-421 induces cell proliferation and apoptosis resistance. •FOXO4 is a direct and functional target of miR-421. -- Abstract: microRNAs have been demonstrated to play important roles in cancer development and progression. Hence, identifying functional microRNAs and better understanding of the underlying molecular mechanisms would provide new clues for the development of targeted cancer therapies. Herein, we reported that a microRNA, miR-421 played an oncogenic role in nasopharyngeal carcinoma. Upregulation of miR-421 induced, whereas inhibition of miR-421 repressed cell proliferation and apoptosis resistance. Furthermore, we found that upregulation of miR-421 inhibited forkhead box protein O4 (FOXO4) signaling pathway following downregulation of p21, p27, Bim and FASL expression by directly targeting FOXO4 3′UTR. Additionally, we demonstrated that FOXO4 expression is critical for miR-421-induced cell growth and apoptosis resistance. Taken together, our findings not only suggest that miR-421 promotes nasopharyngeal carcinoma cell proliferation and anti-apoptosis, but also uncover a novel regulatory mechanism for inactivation of FOXO4 in nasopharyngeal carcinoma.

  5. Roles of miRNAs in microcystin-LR-induced Sertoli cell toxicity

    SciTech Connect

    Zhou, Yuan; Wang, Hui; Wang, Cong; Qiu, Xuefeng; Benson, Mikael; Yin, Xiaoqin; Xiang, Zou; Li, Dongmei; and others

    2015-08-15

    Microcystin (MC)-LR, a cyclic heptapeptide, is a potent reproductive system toxin. To understand the molecular mechanisms of MC-induced reproductive system cytotoxicity, we evaluated global changes of miRNA and mRNA expression in mouse Sertoli cells following MC-LR treatment. Our results revealed that the exposure to MC-LR resulted in an altered miRNA expression profile that might be responsible for the modulation of mRNA expression. Bio-functional analysis indicated that the altered genes were involved in specific cellular processes, including cell death and proliferation. Target gene analysis suggested that junction injury in Sertoli cells exposed to MC-LR might be mediated by miRNAs through the regulation of the Sertoli cell-Sertoli cell pathway. Collectively, these findings may enhance our understanding on the modes of action of MC-LR on mouse Sertoli cells as well as the molecular mechanisms underlying the toxicity of MC-LR on the male reproductive system. - Highlights: • miRNAs were altered in Sertoli cells exposed to MC-LR. • Alerted genes were involved in different cell functions including the cell morphology. • MC-LR adversely affected Sertoli cell junction formation through the regulating miRNAs.

  6. NE-23

    Office of Legacy Management (LM)

    4:00 p.m., Monday through Friday (except Federal holidays), at the DOE Public Document Room located in Room lE-190 of the Forrestal Building, 1000 Independence Avenue, S.W.,...

  7. NE-24

    Office of Legacy Management (LM)

    the Bureau of Hines Site at Albany, Oregon, for Remedial Action Under the Formerly Utilized Sites Remedial Action Program I L@ _I' J.-La&one, Manager Oak Ridge Operations Office Based on the data in the attached draft reports, it has been determined that the subject site is contaminated with residual radioactive material ' as a result of Manhattan Engineer District/Atomic Energy Commission operations P * at this site. The contamination is in excess of the acceptable guidelines and warrants

  8. NE-23,

    Office of Legacy Management (LM)

    Joseph A. Warburton Chainnan, Radiological and Toxicological Safety Board University of Nevada System DRIASC, P.O. Box 60220 Reno, Nevada 89506 Dear Dr. Warburton: The Department ...

  9. 20Ne

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

  10. NE-24

    Office of Legacy Management (LM)

    of Terminal Waste Disposal and Remedial Action Office of Nuclear Energy DOE,; ;;f".' ... Onsite (1) NL Industries internal memo dated June 3, 1982, re: NL Cost and Pricing ...

  11. NE-23:

    Office of Legacy Management (LM)

    whether it contains residual radioactivity traceable to activities conducted on behalf of the Manhattan Engineer District or the Atomic Energy Commission (predecessors to DOE). ...

  12. 18Ne

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

  13. 19Ne

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

  14. Ionizing Radiation–Inducible miR-27b Suppresses Leukemia Proliferation via Targeting Cyclin A2

    SciTech Connect

    Wang, Bo; Li, Dongping; Kovalchuk, Anna; Litvinov, Dmitry; Kovalchuk, Olga

    2014-09-01

    Purpose: Ionizing radiation is a common carcinogen that is important for the development of leukemia. However, the underlying epigenetic mechanisms remain largely unknown. The goal of the study was to explore microRNAome alterations induced by ionizing radiation (IR) in murine thymus, and to determine the role of IR-inducible microRNA (miRNA/miR) in the development of leukemia. Methods and Materials: We used the well-established C57BL/6 mouse model and miRNA microarray profiling to identify miRNAs that are differentially expressed in murine thymus in response to irradiation. TIB152 human leukemia cell line was used to determine the role of estrogen receptor–α (ERα) in miR-27b transcription. The biological effects of ectopic miR-27b on leukemogenesis were measured by western immunoblotting, cell viability, apoptosis, and cell cycle analyses. Results: Here, we have shown that IR triggers the differential expression of miR-27b in murine thymus tissue in a dose-, time- and sex-dependent manner. miR-27b was significantly down-regulated in leukemia cell lines CCL119 and TIB152. Interestingly, ERα was overexpressed in those 2 cell lines, and it was inversely correlated with miR-27b expression. Therefore, we used TIB152 as a model system to determine the role of ERα in miR-27b expression and the contribution of miR-27b to leukemogenesis. β-Estradiol caused a rapid and transient reduction in miR-27b expression reversed by either ERα-neutralizing antibody or ERK1/2 inhibitor. Ectopic expression of miR-27b remarkably suppressed TIB152 cell proliferation, at least in part, by inducing S-phase arrest. In addition, it attenuated the expression of cyclin A2, although it had no effect on the levels of PCNA, PPARγ, CDK2, p21, p27, p-p53, and cleaved caspase-3. Conclusion: Our data reveal that β-estradiol/ERα signaling may contribute to the down-regulation of miR-27b in acute leukemia cell lines through the ERK1/2 pathway, and that miR-27b may function as a tumor

  15. Curcumin inhibits oral squamous cell carcinoma SCC-9 cells proliferation by regulating miR-9 expression

    SciTech Connect

    Xiao, Can; Wang, Lili; Zhu, Lifang; Zhang, Chenping; Zhou, Jianhua

    2014-11-28

    Highlights: • miR-9 expression level was significantly decreased in OSCC tissues. • Curcumin significantly inhibited SCC-9 cells proliferation. • miR-9 mediates the inhibition of SCC-9 proliferation by curcumin. • Curcumin suppresses Wnt/β-catenin signaling in SCC-9 cells. • miR-9 mediates the suppression of Wnt/β-catenin signaling by curcumin. - Abstract: Curcumin, a phytochemical derived from the rhizome of Curcuma longa, has shown anticancer effects against a variety of tumors. In the present study, we investigated the effects of curcumin on the miR-9 expression in oral squamous cell carcinoma (OSCC) and explored the potential relationships between miR-9 and Wnt/β-catenin pathway in curcumin-mediated OSCC inhibition in vitro. As the results shown, the expression levels of miR-9 were significantly lower in clinical OSCC specimens than those in the adjacent non-tumor tissues. Furthermore, our results indicated that curcumin inhibited OSCC cells (SCC-9 cells) proliferation through up-regulating miR-9 expression, and suppressing Wnt/β-catenin signaling by increasing the expression levels of the GSK-3β, phosphorylated GSK-3β and β-catenin, and decreasing the cyclin D1 level. Additionally, the up-regulation of miR-9 by curcumin in SCC-9 cells was significantly inhibited by delivering anti-miR-9 but not control oligonucleotides. Downregulation of miR-9 by anti-miR-9 not only attenuated the growth-suppressive effects of curcumin on SCC-9 cells, but also re-activated Wnt/β-catenin signaling that was inhibited by curcumin. Therefore, our findings would provide a new insight into the use of curcumin against OSCC in future.

  16. miR-339-5p inhibits alcohol-induced brain inflammation through regulating NF-κB pathway

    SciTech Connect

    Zhang, Yu; Wei, Guangkuan; Di, Zhiyong; Zhao, Qingjie

    2014-09-26

    Graphical abstract: - Highlights: • Alcohol upregulates miR-339-5p expression. • miR-339-5p inhibits the NF-kB pathway. • miR-339-5p interacts with and blocks activity of IKK-beat and IKK-epsilon. • miR-339-5p modulates IL-1β, IL-6 and TNF-α. - Abstract: Alcohol-induced neuroinflammation is mediated by the innate immunesystem. Pro-inflammatory responses to alcohol are modulated by miRNAs. The miRNA miR-339-5p has previously been found to be upregulated in alcohol-induced neuroinflammation. However, little has been elucidated on the regulatory functions of this miRNA in alcohol-induced neuroinflammation. We investigated the function of miR-339-5p in alcohol exposed brain tissue and isolated microglial cells using ex vivo and in vitro techniques. Our results show that alcohol induces transcription of miR 339-5p, IL-6, IL-1β and TNF-α in mouse brain tissue and isolated microglial cells by activating NF-κB. Alcohol activation of NF-κB allows for nuclear translocation of the NF-κB subunit p65 and expression of pro-inflammatory mediators. miR-339-5p inhibited expression of these pro-inflammatory factors through the NF-κB pathway by abolishing IKK-β and IKK-ε activity.

  17. miR-208-3p promotes hepatocellular carcinoma cell proliferation and invasion through regulating ARID2 expression

    SciTech Connect

    Yu, Peng; Wu, Dingguo; You, Yu; Sun, Jing; Lu, Lele; Tan, Jiaxing; Bie, Ping

    2015-08-15

    MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at post-transcriptional level. miRNA dysregulation plays a causal role in cancer progression. In this study, miR-208-3p was highly expressed and directly repressed ARID2 expression. As a result, ARID2 expression in hepatocellular carcinoma (HCC) was decreased. In vitro, miR-208-3p down-regulation and ARID2 over-expression elicited similar inhibitory effects on HCC cell proliferation and invasion. In vivo test results revealed that miR-208-3p down-regulation inhibited HCC tumorigenesis in Hep3B cells. Moreover, ARID2 was possibly a downstream element of transforming growth factor beta1 (TGFβ1)/miR-208-3p/ARID2 regulatory pathway. These findings suggested that miR-208-3p up-regulation is associated with HCC cell progression and may provide a new target for liver cancer treatment. - Highlights: • miR-208-3p was highly expressed and directly repressed the expression of ARID2 in HCC. • miR-208-3p contributed to HCC cell progression both in vitro and in vivo. • Over-expression of ARID2 inhibited the HCC cell proliferation and invasion. • Restoration of ARID2 partly reversed the the effect of miR-208-3p down-regulation on HCC cells. • Newly regulatory pathway: miR-208-3p mediated the repression of ARID2 by TGFβ1 in HCC cells.

  18. West KY Regional Middle School Science Bowl

    Energy.gov [DOE]

    Deegan Lawrence (far right) from Henderson County North Middle School gives an answer as teammates D.J. Banks (middle) and Alex Chandler look on during DOE’s West Kentucky Regional Middle School Science Bowl in Paducah February 6. Henderson North won the competition and will compete in DOE’s National Science Bowl® in Washington, D.C. April 30 through May 4.

  19. Application for Presidential Permit OE Docket No. PP-400 TDI-NE New England

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Clean Power Link Project: Comments and Motion to Intervene Out of Time of Allco Renewable Energy Limited from TDI | Department of Energy New England Clean Power Link Project: Comments and Motion to Intervene Out of Time of Allco Renewable Energy Limited from TDI Application for Presidential Permit OE Docket No. PP-400 TDI-NE New England Clean Power Link Project: Comments and Motion to Intervene Out of Time of Allco Renewable Energy Limited from TDI TDI offers their response to Allco

  20. HIA 2015 DOE Zero Energy Ready Home Case Study: Charles Thomas Homes, Anna Model, Omaha, NE

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Thomas Homes Anna Model Omaha, NE DOE ZERO ENERGY READY HOME(tm) The U.S. Department of Energy invites home builders across the country to meet the extraordinary levels of excellence and quality specified in DOE's Zero Energy Ready Home program (formerly known as Challenge Home). Every DOE Zero Energy Ready Home starts with ENERGY STAR Certified Homes Version 3.0 for an energy-efficient home built on a solid foundation of building science research. Advanced technologies are designed in to give

  1. MiniBooNE Neutrino Physics at the University of Alabama

    SciTech Connect

    Stancu, Ion

    2007-04-27

    This report summarizes the activities conducted by the UA group under the auspices of the DoE/EPSCoR grant number DE--FG02--04ER46112 since the date of the previous progress report, i.e., since November 2005. It also provides a final report of the accomplishments achieved during the entire period of this grant (February 2004 to January 2007). The grant has fully supported the work of Dr. Yong Liu (postdoctoral research assistant -- in residence at Fermilab) on the MiniBooNE reconstruction and particle identification (PID) algorithms.

  2. Effectiveness of projectile screening in single and multiple ionization of Ne by B{sup 2+}

    SciTech Connect

    Wolff, W.; Luna, H.; Santos, A. C. F.; Montenegro, E. C.; DuBois, R. D.; Montanari, C. C.; Miraglia, J. E.

    2011-10-15

    Pure multiple ionization cross sections of Ne by B{sup 2+} projectiles have been measured in the energy range of 0.75 to 4.0 MeV and calculated using the continuum distorted wave-eikonal initial state approximation. The experiment and calculations show that the ionization cross sections by B{sup 2+}, principally for the production of highly charged recoils, is strongly enhanced when compared to the bare projectile with the same charge state, He{sup 2+}, at the same velocities.

  3. DOE-NE Proliferation and Terrorism Risk Assessment: FY12 Plans Update

    SciTech Connect

    Sadasivan, Pratap

    2012-06-21

    This presentation provides background information on FY12 plans for the DOE Office of Nuclear Energy Proliferation and Terrorism Risk Assessment program. Program plans, organization, and individual project elements are described. Research objectives are: (1) Develop technologies and other solutions that can improve the reliability, sustain the safety, and extend the life of current reactors; (2) Develop improvements in the affordability of new reactors to enable nuclear energy; (3) Develop Sustainable Nuclear Fuel Cycles; and (4) Understand and minimize the risks of nuclear proliferation and terrorism - Goal is to enable the use of risk information to inform NE R&D program planning.

  4. Microsoft Word - MicroBooNE CD-3b appr.docx

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    3b Approve Start of Full Construction of the Micro Booster Neutrino Project at the Fermi National Accelerator Laboratory Office of High Energy Physics Office of Science A. Purpose The purpose of this document is to record the review and approval by the Office of Science Energy Systems Acquisition Advisory Board-equivalent for Critical Decision (CD) 3b "Approve Start of Full Construction" for the Micro Booster Neutrino (MicroBooNE) Project at the Fermi National Accelerator Laboratory

  5. MiniBooNE Charged Current Neutral Pion Cross Section Data Release

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Muon Neutrino Induced Charged Current Neutral Pion Cross Sections on Mineral Oil at Enu=0.5-2.0 GeV" , arXiv:1010.3264 [hep-ex] The following MiniBooNE information for the 2010 CC π0 cross section paper is made available to the public. Each of the following tables contains: The bin boundaries and units. The central-value measurement or prediction with its units and multiplicative factor. The statistical uncertainty per bin of each measurement with its units and multiplicative factor. The

  6. MicroRNAs expression in ox-LDL treated HUVECs: MiR-365 modulates apoptosis and Bcl-2 expression

    SciTech Connect

    Qin, Bing; Xiao, Bo; Liang, Desheng; Xia, Jian; Li, Ye; Yang, Huan

    2011-06-24

    Highlights: {yields} We evaluated the role of miRNAs in ox-LDL induced apoptosis in ECs. {yields} We found 4 up-regulated and 11 down-regulated miRNAs in apoptotic ECs. {yields} Target genes of the dysregulated miRNAs regulate ECs apoptosis and atherosclerosis. {yields} MiR-365 promotes ECs apoptosis via suppressing Bcl-2 expression. {yields} MiR-365 inhibitor alleviates ECs apoptosis induced by ox-LDL. -- Abstract: Endothelial cells (ECs) apoptosis induced by oxidized low-density lipoprotein (ox-LDL) is thought to play a critical role in atherosclerosis. MicroRNAs (miRNAs) are a class of noncoding RNAs that posttranscriptionally regulate the expression of genes involved in diverse cell functions, including differentiation, growth, proliferation, and apoptosis. However, whether miRNAs are associated with ox-LDL induced apoptosis and their effect on ECs is still unknown. Therefore, this study evaluated potential miRNAs and their involvement in ECs apoptosis in response to ox-LDL stimulation. Microarray and qRT-PCR analysis performed on human umbilical vein endothelial cells (HUVECs) exposed to ox-LDL identified 15 differentially expressed (4 up- and 11 down-regulated) miRNAs. Web-based query tools were utilized to predict the target genes of the differentially expressed miRNAs, and the potential target genes were classified into different function categories with the gene ontology (GO) term and KEGG pathway annotation. In particular, bioinformatics analysis suggested that anti-apoptotic protein B-cell CLL/lymphoma 2 (Bcl-2) is a target gene of miR-365, an apoptomir up-regulated by ox-LDL stimulation in HUVECs. We further showed that transfection of miR-365 inhibitor partly restored Bcl-2 expression at both mRNA and protein levels, leading to a reduction of ox-LDL-mediated apoptosis in HUVECs. Taken together, our findings indicate that miRNAs participate in ox-LDL-mediated apoptosis in HUVECs. MiR-365 potentiates ox-LDL-induced ECs apoptosis by regulating the

  7. MiRNA-125a-5p inhibits glioblastoma cell proliferation and promotes cell differentiation by targeting TAZ

    SciTech Connect

    Yuan, Jian; Xiao, Gelei; Peng, Gang; Liu, Dingyang; Wang, Zeyou; Liao, Yiwei; Liu, Qing; Wu, Minghua; Yuan, Xianrui

    2015-02-06

    Highlights: • Expression of miR-125a-5p is inversely correlated with that of TAZ in glioma cells. • MiR-125a-5p represses TAZ expression in glioma cells. • MiR-125a-5p directly targets the 3′ UTR of TAZ mRNA and promotes its degradation. • MiR-125a-5p represses CTGF and survivin via TAZ, and inhibits glioma cell growth. • MiR-125a-5p inhibits the stem cell features of HFU-251 MG cells. - Abstract: Glioblastoma (GBM) is the most lethal brain tumor due to the resistance to conventional therapies, such as radiotherapy and chemotherapy. TAZ, an important mediator of the Hippo pathway, was found to be up-regulated in diverse cancers, including in GBM, and plays important roles in tumor initiation and progression. However, little is known about the regulation of TAZ expression in tumors. In this study, we found that miR-125a-5p is an important regulator of TAZ in glioma cells by directly targeting the TAZ 3′ UTR. MiR-125a-5p levels are inversely correlated with that of TAZ in normal astrocytes and a panel of glioma cell lines. MiR-125a-5p represses the expression of TAZ target genes, including CTGF and survivin, and inhibits cell proliferation and induces the differentiation of GBM cells; whereas over-expression of TAZ rescues the effects of miR-125a-5p. This study revealed a mechanism for TAZ deregulation in glioma cells, and also demonstrated a tumor suppressor role of miR-125a-5p in glioblastoma cells.

  8. OZONE PRODUCTION IN THE PHILADELPHIA URBAN AREA DURING NE-OPS 99.

    SciTech Connect

    KLEINMAN,L.I.; DAUM,P.H.; BRECHTEL,F.; LEE,Y.N.; NUNNERMACKER,L.J.; SPRINGSTON,S.R.; WEINSTEIN-LLOYD,J.

    2001-10-01

    As part of the 1999 NARSTO Northeast Oxidant and Particulate Study (NE-OPS) field campaign, the DOE G-1 aircraft sampled trace gases and aerosols in and around the Philadelphia metropolitan area. Twenty research flights were conducted between July 25 and August 11. The overall goals of these flights were to obtain a mechanistic understanding of O{sub 3} production; to characterize the spatial and temporal behavior of photo-oxidants and aerosols; and to study the evolution of aerosol size distributions, including the process of new particle formation. Within the NE-OPS program, other groups provided additional trace gas, aerosol, and meteorological observations using aircraft, balloon, remote sensing, and surface based instruments (Phillbrick et al., 2000). In this article we provide an overview of the G-1 observations related to O{sub 3} production, focusing on the vertical distribution of pollutants. Ozone production rates are calculated using a box model that is constrained by observed trace gas concentrations. Highest O{sub 3} concentrations were observed on July 31, which we present as a case study. On that day, O{sub 3} concentrations above the 1-hour 120 ppb standard were observed downwind of Philadelphia and also in the plume of a single industrial facility located on the Delaware River south of the city.

  9. Liquid Argon Dielectric Breakdown Studies with the MicroBooNE Purification System

    SciTech Connect

    Acciarri, R.; Carls, B.; James, C.; Johnson, B.; Jostlein, H.; Lockwitz, S.; Lundberg, B.; Raaf, J. L.; Rameika, R.; Rebel, B.; Zeller, G. P.; Zuckerbrot, M.

    2014-11-04

    The proliferation of liquid argon time projection chamber detectors makes the characterization of the dielectric properties of liquid argon a critical task. To improve understanding of these properties, a systematic study of the breakdown electric field in liquid argon was conducted using a dedicated cryostat connected to the MicroBooNE cryogenic system at Fermilab. An electrode sphere-plate geometry was implemented using spheres with diameters of 1.3 mm, 5.0 mm, and 76 mm. The MicroBooNE cryogenic system allowed measurements to be taken at a variety of electronegative contamination levels ranging from a few parts-per-million to tens of parts-per-trillion. The cathode-anode distance was varied from 0.1 mm to 2.5 cm. The results demonstrate a geometric dependence of the electric field strength at breakdown. This study is the first time that the dependence of the breakdown field on stressed cathode area has been shown for liquid argon.

  10. Photoionization-pumped, Ne II, x-ray laser studies project. Final report

    SciTech Connect

    Richardson, M.C.; Hagelstein, P.L.; Eckart, M.J.; Forsyth, J.M.; Gerrassimenko, M.; Soures, J.M.

    1984-01-01

    The energetics of this pumping scheme are shown. Short-pulse (50 to 100 ps) laser irradiation of an appropriate x-ray flashlamp medium generates broad-band emission in the range of 300 to 800 eV which preferentially photoionizes Ne to the /sup 2/S state of Ne II creating an inversion at approximately 27 eV. Although this approach does not depend on precise spectral overlap between the x-ray pump radiation and the medium to be pumped, it does require that the x-ray medium remain un-ionized prior to photoionization by the soft x-ray emission. Well-controlled focus conditions are required to ensure that the x-ray medium is not subjected to electron or x-ray preheat prior to irradiation by the soft x-ray source. The magnitude of the population inversion is predicted to be critically dependent upon rapid photoionization of the two states; therefore, ultra-short pulse irradiation of the laser flashlamps is required.

  11. The NuMI proton beam at Fermilab successes and challenges

    SciTech Connect

    Childress, S.; /Fermilab

    2008-11-01

    The NuMI beam at Fermilab has delivered over 5 x 10{sup 20} 120 GeV protons to the neutrino production target since the start for MINOS [1] neutrino oscillation experiment operation in 2005. We report on proton beam commissioning and operation status, including successes and challenges with this beam.

  12. DOE Zero Energy Ready Home Case Study: Cobblestone Homes, Midland, MI

    Office of Energy Efficiency and Renewable Energy (EERE)

    Case study of a DOE Zero Energy Ready home in Midland, MI, that scored HERS 49 without PV or HERS 44 with 1.4 kW of PV. The custom home served as a prototype and energy efficiency demonstration...

  13. Wave packet and statistical quantum calculations for the He + NeH{sup +} → HeH{sup +} + Ne reaction on the ground electronic state

    SciTech Connect

    Koner, Debasish; Panda, Aditya N.; Barrios, Lizandra; González-Lezana, Tomás

    2014-09-21

    A real wave packet based time-dependent method and a statistical quantum method have been used to study the He + NeH{sup +} (v, j) reaction with the reactant in various ro-vibrational states, on a recently calculated ab initio ground state potential energy surface. Both the wave packet and statistical quantum calculations were carried out within the centrifugal sudden approximation as well as using the exact Hamiltonian. Quantum reaction probabilities exhibit dense oscillatory pattern for smaller total angular momentum values, which is a signature of resonances in a complex forming mechanism for the title reaction. Significant differences, found between exact and approximate quantum reaction cross sections, highlight the importance of inclusion of Coriolis coupling in the calculations. Statistical results are in fairly good agreement with the exact quantum results, for ground ro-vibrational states of the reactant. Vibrational excitation greatly enhances the reaction cross sections, whereas rotational excitation has relatively small effect on the reaction. The nature of the reaction cross section curves is dependent on the initial vibrational state of the reactant and is typical of a late barrier type potential energy profile.

  14. MiR-18a regulates the proliferation, migration and invasion of human glioblastoma cell by targeting neogenin

    SciTech Connect

    Song, Yichen; Wang, Ping; Zhao, Wei; Yao, Yilong; Liu, Xiaobai; Ma, Jun; Xue, Yixue; Liu, Yunhui

    2014-05-15

    MiR-17-92 cluster has recently been reported as an oncogene in some tumors. However, the association of miR-18a, an important member of this cluster, with glioblastoma remains unknown. Therefore, this study aims to investigate the expression of miR-18a in glioblastoma and its role in biological behavior of U87 and U251 human glioblastoma cell lines. Quantitative RT-PCR results showed that miR-18a was highly expressed in glioblastoma tissues and U87 and U251 cell lines compared with that in human brain tissues and primary normal human astrocytes, and the expression levels were increased along with the rising pathological grades of glioblastoma. Neogenin was identified as the target gene of miR-18a by dual-luciferase reporter assays. RT-PCR and western blot results showed that its expression levels were decreased along with the rising pathological grades of glioblastoma. Inhibition of miR-18a expression was established by transfecting exogenous miR-18a inhibitor into U87 and U251 cells, and its effects on the biological behavior of glioblastoma cells were studied using CCK-8 assay, transwell assay and flow cytometry. Inhibition of miR-18a expression in U87 and U251 cells significantly up-regulated neogenin, and dramatically suppressed the abilities of cell proliferation, migration and invasion, induced cell cycle arrest and promoted cellular apoptosis. Collectively, these results suggest that miR-18a may regulate biological behavior of human glioblastoma cells by targeting neogenin, and miR-18a can serve as a potential target in the treatment of glioblastoma. - Highlights: • MiR-18a was highly expressed in glioblastoma tissues and U87 and U251 cell lines. • Neogenin was identified as the target gene of miR-18a. • Neogenin expressions were decreased along with the rising pathological grades of glioblastoma. • Inhibition of miR-18a suppressed biological behavior of glioma cells by up-regulating neogenin.

  15. miR-7 and miR-218 epigenetically control tumor suppressor genes RASSF1A and Claudin-6 by targeting HoxB3 in breast cancer

    SciTech Connect

    Li, Qiaoyan; Zhu, Fufan; Chen, Puxiang

    2012-07-20

    Highlights: Black-Right-Pointing-Pointer Both miR-7 and miR-218 down-regulates HoxB3 expression by targeting the 3 Prime -UTR of HoxB3 mRNA. Black-Right-Pointing-Pointer A reverse correlation between the levels of endogenous miR-7, miR218 and HoxB3 expression. Black-Right-Pointing-Pointer Epigenetic changes involve in the reactivation of HoxB3. Black-Right-Pointing-Pointer Both miRNAs inhibits the cell cycle and clone formation of breast cancer cells. -- Abstract: Many microRNAs have been implicated as key regulators of cellular growth and differentiation and have been found to dysregulate proliferation in human tumors, including breast cancer. Cancer-linked microRNAs also alter the epigenetic landscape by way of DNA methylation and post-translational modifications of histones. Aberrations in Hox gene expression are important for oncogene or tumor suppressor during abnormal development and malignancy. Although recent studies suggest that HoxB3 is critical in breast cancer, the putative role(s) of microRNAs impinging on HoxB3 is not yet fully understood. In this study, we found that the expression levels of miR-7 and miR-218 were strongly and reversely associated with HoxB3 expression. Stable overexpression of miR-7 and miR-218 was accompanied by reactivation of tumor suppressor genes including RASSF1A and Claudin-6 by means of epigenetic switches in DNA methylation and histone modification, giving rise to inhibition of the cell cycle and clone formation of breast cancer cells. The current study provides a novel link between overexpression of collinear Hox genes and multiple microRNAs in human breast malignancy.

  16. QSO ABSORPTION SYSTEMS DETECTED IN Ne VIII: HIGH-METALLICITY CLOUDS WITH A LARGE EFFECTIVE CROSS SECTION

    SciTech Connect

    Meiring, J. D.; Tripp, T. M. [Department of Astronomy, University of Massachusetts, Amherst, MA 01003 (United States)] [Department of Astronomy, University of Massachusetts, Amherst, MA 01003 (United States); Werk, J. K.; Prochaska, J. X. [University of California Observatories-Lick Observatory, UC Santa Cruz, CA 95064 (United States)] [University of California Observatories-Lick Observatory, UC Santa Cruz, CA 95064 (United States); Howk, J. C. [Department of Physics, University of Notre Dame, 225 Nieuwland Science Hall, Notre Dame, IN 46556 (United States)] [Department of Physics, University of Notre Dame, 225 Nieuwland Science Hall, Notre Dame, IN 46556 (United States); Jenkins, E. B. [Princeton University Observatory, Peyton Hall, Ivy Lane, Princeton, NJ 08544 (United States)] [Princeton University Observatory, Peyton Hall, Ivy Lane, Princeton, NJ 08544 (United States); Lehner, N.; Sembach, K. R. [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States)] [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States)

    2013-04-10

    Using high-resolution, high signal-to-noise ultraviolet spectra of the z{sub em} = 0.9754 quasar PG1148+549 obtained with the Cosmic Origins Spectrograph (COS) on the Hubble Space Telescope, we study the physical conditions and abundances of Ne VIII+O VI absorption line systems at z{sub abs} = 0.68381, 0.70152, 0.72478. In addition to Ne VIII and O VI, absorption lines from multiple ionization stages of oxygen (O II, O III, O IV) are detected and are well aligned with the more highly ionized species. We show that these absorbers are multiphase systems including hot gas (T Almost-Equal-To 10{sup 5.7} K) that produces Ne VIII and O VI, and the gas metallicity of the cool phase ranges from Z = 0.3 Z{sub Sun} to supersolar. The cool ( Almost-Equal-To 10{sup 4} K) phases have densities n{sub H} Almost-Equal-To 10{sup -4} cm{sup -3} and small sizes (<4 kpc); these cool clouds are likely to expand and dissipate, and the Ne VIII may be within a transition layer between the cool gas and a surrounding, much hotter medium. The Ne VIII redshift density, dN/dz{approx}7{sup +7}{sub -3}, requires a large number of these clouds for every L > 0.1 L* galaxy and a large effective absorption cross section ({approx}> 100 kpc), and indeed, we find a star-forming {approx}L {sup *} galaxy at the redshift of the z{sub abs} = 0.72478 system, at an impact parameter of 217 kpc. Multiphase absorbers like these Ne VIII systems are likely to be an important reservoir of baryons and metals in the circumgalactic media of galaxies.

  17. Loss of expression of miR-335 is implicated in hepatic stellate cell migration and activation

    SciTech Connect

    Chen, Chao; Wu, Chao-Qun; Zhang, Zong-Qi; Yao, Ding-Kang; Zhu, Liang

    2011-07-15

    Activation and migration of resident stellate cells (HSCs) within the hepatic space of Disse play an important role in hepatic fibrosis, which accounts for the increased numbers of activated HSCs in areas of inflammation during hepatic fibrosis. Currently, microRNAs have been found to play essential roles in HSC differentiation, proliferation, apoptosis, fat accumulation and collagen production. However, little is known about microRNA mediated HSC activation and migration. In this study, the miRNA expression profiles of quiescent HSCs, partially activated HSCs and fully activated HSCs were compared in pairs. Gene ontology (GO) and GO-Map network analysis indicated that the activation of HSCs was regulated by microRNAs. Among them miR-335 was confirmed to be significantly reduced during HSC activation by qRT-PCR, and restoring expression of miR-335 inhibited HSC migration and reduced {alpha}-SMA and collagen type I. Previous study revealed that tenascin-C (TNC), an extracellular matrix glycoprotein involved in cell migration, might be a target of miR-335. Therefore, we further studied the TNC expression in miR-335 over-expressed HSCs. Our data showed that exogenous TNC could enhance HSC migration in vitro and miR-335 restoration resulted in a significant inhibition of TNC expression. These results demonstrated that miR-335 restoration inhibited HSC migration, at least in part, via downregulating the TNC expression.

  18. Prospective benefits analysis of the DOE Nuclear Energy portfolio: NE R&D program data assumptions, approach, & results

    SciTech Connect

    Bhatt, Vatsal; Friley, Paul; Lee, John; Reisman, Ann

    2006-10-31

    The Office of Nuclear Energy (NE) leads the U.S. Government’s efforts to develop new nuclear energy generation technologies to meet energy and climate goals, and to develop advanced proliferation-resistant nuclear fuel technologies that maximize energy from nuclear fuel; contributes to the R&D for a possible transition to a hydrogen economy; and maintains and enhances the national nuclear technology infrastructure. NE serves the present and future energy needs of the Nation by managing the safe operation and maintenance of the Department of Energy (DOE) critical nuclear in frastructure, providing nuclear technology goods and services, and conducting R&D.

  19. New Results from MiniBooNE Charged-Current Quasi-Elastic Anti-Neutrino Data

    SciTech Connect

    Grange, Joseph

    2011-07-01

    MiniBooNE anti-neutrino charged-current quasi-elastic (CCQE) data is compared to model predictions. The main background of neutrino-induced events is examined first, where three independent techniques are employed. Results indicate the neutrino flux is consistent with a uniform reduction of {approx}20% relative to the largely uncertain prediction. After background subtraction, the Q{sup 2} shape of {bar v}{sub {mu}} CCQE events is consistent with the model parameter MA = 1.35 GeV determined from MiniBooNE v{sub {mu}} CCQE data, while the normalization is {approx} 20% high compared to the same prediction.

  20. PSMB4 promotes multiple myeloma cell growth by activating NF-κB-miR-21 signaling

    SciTech Connect

    Zheng, Peihao; Guo, Honggang; Li, Guangchao; Han, Siqi; Luo, Fei; Liu, Yi

    2015-03-06

    Proteasomal subunit PSMB4, was recently identified as potential cancer driver genes in several tumors. However, the regulatory mechanism of PSMB4 on carcinogenesis process remains unclear. In this study, we investigated the expression and roles of PSMB4 in multiple myeloma (MM). We found a significant up-regulation of PSMB4 in MM plasma and cell lines. Ectopic overexpression of PSMB4 promoted cell growth and colony forming ability of MM cells, whereas inhibition of PSMB4 led to a decrease of such events. Furthermore, our results demonstrated the up-regulation of miR-21 and a positive correlation between the levels of miR-21 and PSMB4 in MM. Re-expression of miR-21 markedly rescued PSMB4 knockdown-mediated suppression of cell proliferation and clone-formation. Additionally, while enforced expression of PSMB4 profoundly increased NF-κB activity and the level of miR-21, PSMB4 knockdown or NF-κB inhibition suppressed miR-21 expression in MM cells. Taken together, our results demonstrated that PSMB4 regulated MM cell growth in part by activating NF-κB-miR-21 signaling, which may represent promising targets for novel specific therapies. - Highlights: • First reported upregulation of PSMB4 in MM plasma and cell lines. • PSMB4 promoted MM cell growth and colony forming ability. • Further found miR-21 was up-regulated by PSMB4 in MM plasma and cell lines. • PSMB4-induced miR-21 expression was modulated by NF-κB. • PSMB4-NF-κB-miR-21 axis may be potential therapeutic targets of MM.

  1. Effect of supplementation on vitamin A and zinc nutriture of children in northeast (NE) Thailand

    SciTech Connect

    Udomkesmalee, E.; Dhanamitta, S.; Charoenklatkul, S.; Tantipopipat, S.; Banjong, O.; Rojroongwasinkul, N.; Kramer, T.R.; Smith, J.C. Jr. USDA, Beltsville, MD )

    1991-03-11

    Previous surveys of the nutritional status of young children in NE Thailand suggested that they may benefit from vitamin A (VA) and/or zinc (Zn) supplementation. 140 children, with low plasma retinol concentrations were entered in a double-blind study. They were randomized and supplemented with either VA, Zn, VA + Zn or placebo each weekday for 6 mos. All subjects consumed their usual diet that provided adequate protein, less than recommended calories, fat, Zn and VA. Biochemical indices of VA and Zn status increased significantly. The children had adequate VA liver stores as assessed by relative dose response. Zn supplementation resulted in improvement of vision restoration time in dim light using rapid dark adaptometry. VA and Zn synergistically normalized conjunctival epithelium after a 6 mo supplementation. Data suggest that functional improvements of populations with suboptimal VA and Zn nutriture can be accomplished by supplementation with {lt}2 times of RDA of these nutrients.

  2. Test of ''Crab-Waist'' Collisions at the DA{Phi}NE {Phi} Factory

    SciTech Connect

    Zobov, M.; Alesini, D.; Biagini, M. E.; Biscari, C.; Bocci, A.; Boni, R.; Boscolo, M.; Bossi, F.; Buonomo, B.; Clozza, A.; Delle Monache, G. O.; Demma, T.; Di Pasquale, E.; Di Pirro, G.; Drago, A.; Gallo, A.; Ghigo, A.; Guiducci, S.; Ligi, C.; Marcellini, F.

    2010-04-30

    The electron-positron collider DA{Phi}NE, the Italian {Phi} factory, has been recently upgraded in order to implement an innovative collision scheme based on large crossing angle, small beam sizes at the crossing point, and compensation of beam-beam interaction by means of sextupole pairs creating a ''crab-waist'' configuration in the interaction region. Experimental tests of the novel scheme exhibited an increase by a factor of 3 in the peak luminosity of the collider with respect to the performances reached before the upgrade. In this Letter we present the new collision scheme, discuss its advantages, describe the hardware modifications realized for the upgrade, and report the results of the experimental tests carried out during commissioning of the machine in the new configuration and standard operation for the users.

  3. AmeriFlux US-Ne3 Mead - rainfed maize-soybean rotation site

    SciTech Connect

    Suyker, Andy

    2016-01-01

    This is the AmeriFlux version of the carbon flux data for the site US-Ne3 Mead - rainfed maize-soybean rotation site. Site Description - The study site is one of three fields (all located within 1.6 km of each other) at the University of Nebraska Agricultural Research and Development Center near Mead, Nebraska. While the other two sites are equipped with irrigation systems, this site relies on rainfall. A tillage operation (disking) was done just prior to the 2001 planting to homogenize the top 0.1 m of soil, incorporate P and K fertilizers, as well as previously accumulated surface residues. Since initiation of the study in 2001, this site has been under no-till management.

  4. Ionization of He, Ne, Ar, Kr, and Xe by impact of He{sup +} ions

    SciTech Connect

    Miraglia, J. E.; Gravielle, M. S.

    2010-04-15

    In this article we report ionization cross sections of neutral He, Ne, Ar, Kr, and Xe by impact of He{sup +} ions with energies ranging from 25 to 1000 keV/amu. A general theory to deal with dressed projectiles is developed in the context of the Continuum-Distorted-Wave Eikonal-Initial-State approximation. The strategy is based on the use of an effective charge defined in terms of the momentum transfer extracted from the first Born approximation and extensively used in the local plasma approximation to deal with ions in solids. The difference between the actual potential of the projectile and the Coulombic effective one used in the distorted wave functions is treated in first perturbative order. Our results show that the proposed approach gives a very good account of available experiments.

  5. AmeriFlux US-Ne2 Mead - irrigated maize-soybean rotation site

    DOE Data Explorer

    Suyker, Andy [University of Nebraska - Lincoln

    2016-01-01

    This is the AmeriFlux version of the carbon flux data for the site US-Ne2 Mead - irrigated maize-soybean rotation site. Site Description - The study site is one of three fields (all located within 1.6 km of each other) at the University of Nebraska Agricultural Research and Development Center near Mead, Nebraska. This site is irrigated with a center pivot system. Prior to the initiation of the study, the irrigated site had a 10-yr history of maize-soybean rotation under no-till. A tillage operation (disking) was done just prior to the 2001 planting to homogenize the top 0.1 m of soil, incorporate P and K fertilizers, as well as previously accumulated surface residues. Since this tillage operation, the site has been under no-till management.

  6. First direct measurement of resonance strengths in {sup 17}O({alpha},{gamma}){sup 21}Ne

    SciTech Connect

    Best, A.; Goerres, J.; Couder, M.; Boer, R. de; Falahat, S.; Kontos, A.; LeBlanc, P. J.; Li, Q.; O'Brien, S.; Sonnabend, K.; Talwar, R.; Uberseder, E.; Wiescher, M.

    2011-05-15

    The reaction {sup 17}O({alpha},{gamma}){sup 21}Ne has been measured by in-beam {gamma} spectroscopy for the first time in the energy range E{sub {alpha}=}750-1650 keV using highly enriched anodized Ta{sub 2}({sup 17}O){sub 5} targets. Resonances were found at E{sub {alpha}=} 1002, 1386, and 1619 keV. Their strengths and primary {gamma}-ray branchings are given. The new results exclude the low reaction rate of Descouvemont and support the rate of Caughlan and Fowler. Implications for the neutron poisoning efficiency of {sup 16}O in the weak s-process are discussed.

  7. MiniBooNE NC 1π0 Cross Section Data Release

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    νμ and ν̅μ induced neutral current single π0 production cross sections on mineral oil at Eν~O(1 GeV)", arXiv:0911.2063 [hep-ex], Phys. Rev. D81, 013005 (2010) The following MiniBooNE information from the 2009 NC 1π0 cross section paper is made available to the public: Neutrino Mode Running νμ NC 1π0 pπ0 Differential Cross Section 1D array of bin boundaries partitioning the momentum of the π0 1D array of the value of the differential cross section in each bin in units of 10-40

  8. RLIP76-dependent suppression of PI3K/AKT/Bcl-2 pathway by miR...

    Office of Scientific and Technical Information (OSTI)

    in prostate cancer Citation Details In-Document Search Title: RLIP76-dependent suppression of PI3KAKTBcl-2 pathway by miR-101 induces apoptosis in prostate cancer MicroRNA-101 ...

  9. Aryl hydrocarbon receptor-dependent regulation of miR-196a expression controls lung fibroblast apoptosis but not proliferation

    SciTech Connect

    Hecht, Emelia; Zago, Michela; Sarill, Miles; Rico de Souza, Angela; Gomez, Alvin; Matthews, Jason; Hamid, Qutayba; Eidelman, David H.; Baglole, Carolyn J.

    2014-11-01

    The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor implicated in the regulation of apoptosis and proliferation. Although activation of the AhR by xenobiotics such as dioxin inhibits the cell cycle and control apoptosis, paradoxically, AhR expression also promotes cell proliferation and survival independent of exogenous ligands. The microRNA (miRNA) miR-196a has also emerged as a regulator of proliferation and apoptosis but a relationship between the AhR and miR-196a is not known. Therefore, we hypothesized that AhR-dependent regulation of endogenous miR-196a expression would promote cell survival and proliferation. Utilizing lung fibroblasts from AhR deficient (AhR{sup −/−}) and wild-type (AhR{sup +/+}) mice, we show that there is ligand-independent regulation of miRNA, including low miR-196a in AhR{sup −/−} cells. Validation by qRT-PCR revealed a significant decrease in basal expression of miR-196a in AhR{sup −/−} compared to AhR{sup +/+} cells. Exposure to AhR agonists benzo[a]pyrene (B[a]P) and FICZ as well as AhR antagonist CH-223191 decreased miR-196a expression in AhR{sup +/+} fibroblasts concomitant with decreased AhR protein levels. There was increased proliferation only in AhR{sup +/+} lung fibroblasts in response to serum, corresponding to a decrease in p27{sup KIP1} protein, a cyclin-dependent kinase inhibitor. Increasing the cellular levels of miR-196a had no effect on proliferation or expression of p27{sup KIP1} in AhR{sup −/−} fibroblasts but attenuated cigarette smoke-induced apoptosis. This study provides the first evidence that AhR expression is essential for the physiological regulation of cellular miRNA levels- including miR-196a. Future experiments designed to elucidate the functional relationship between the AhR and miR-196a may delineate additional novel ligand-independent roles for the AhR. - Highlights: • The AhR controls proliferation and apoptosis in lung cells. • The AhR regulates the

  10. Material Activation Benchmark Experiments at the NuMI Hadron Absorber Hall in Fermilab

    SciTech Connect

    Matsumura, H.; Matsuda, N.; Kasugai, Y.; Toyoda, A.; Yashima, H.; Sekimoto, S.; Iwase, H.; Oishi, K.; Sakamoto, Y.; Nakashima, H.; Leveling, A.; Boehnlein, D.; Lauten, G.; Mokhov, N.; Vaziri, K.

    2014-06-15

    In our previous study, double and mirror symmetric activation peaks found for Al and Au arranged spatially on the back of the Hadron absorber of the NuMI beamline in Fermilab were considerably higher than those expected purely from muon-induced reactions. From material activation bench-mark experiments, we conclude that this activation is due to hadrons with energy greater than 3 GeV that had passed downstream through small gaps in the hadron absorber.

  11. Measurement of Pi-K Ratios from the NuMI Target

    SciTech Connect

    Seun, Sin Man

    2007-07-01

    Interactions of protons (p) with the NuMI (Neutrinos at the Main Injector) target are used to create the neutrino beam for the MINOS (Main Injector Neutrino Oscillation Search) Experiment. Using the MIPP (Main Injector Particle Production) experimental apparatus, the production of charged pions and kaons in p+NuMI interactions is studied. The data come from a sample of 2 x 106 events obtained by MIPP using the 120 GeV/c proton beam from the Main Injector at Fermi National Accelerator Laboratory in Illinois, USA. Pions and kaons are identified by measurement in a Ring Imaging Cherenkov detector. Presented are measurements of π-+, K-/K+, π+/K+ and π-/K- production ratios in the momentum range pT < 2 GeV/c transversely and 20 GeV/c < pz < 90 GeV/c longitudinally. Also provided are detailed comparisons of the MIPP NuMI data with the MIPP Thin Carbon data, the MIPP Monte Carlo simulation and the current MINOS models in the relevant momentum ranges.

  12. miR-21 modulates tumor outgrowth induced by human adipose tissue-derived mesenchymal stem cells in vivo

    SciTech Connect

    Shin, Keun Koo; Lee, Ae Lim; Kim, Jee Young; Medical Research Center for Ischemic Tissue Engineering, Pusan National University, Yangsan, Gyeongnam 626-870; BK21 Medical Science Education Center, School of Medicine, Pusan National University, Yangsan, Gyeongnam 626-870 ; Lee, Sun Young; Medical Research Center for Ischemic Tissue Engineering, Pusan National University, Yangsan, Gyeongnam 626-870 ; Bae, Yong Chan; Jung, Jin Sup

    2012-06-15

    Highlights: Black-Right-Pointing-Pointer miR-21 modulates hADSC-induced increase of tumor growth. Black-Right-Pointing-Pointer The action is mostly mediated by the modulation of TGF-{beta} signaling. Black-Right-Pointing-Pointer Inhibition of miR-21 enhances the blood flow recovery in hindlimb ischemia. -- Abstract: Mesenchymal stem cells (MSCs) have generated a great deal of interest in clinical situations, due principally to their potential use in regenerative medicine and tissue engineering applications. However, the therapeutic application of MSCs remains limited, unless the favorable effects of MSCs on tumor growth in vivo, and the long-term safety of the clinical applications of MSCs, can be more thoroughly understood. In this study, we determined whether microRNAs can modulate MSC-induced tumor outgrowth in BALB/c nude mice. Overexpression of miR-21 in human adipose-derived stem cells (hADSCs) inhibited hADSC-induced tumor growth, and inhibition of miR-21 increased it. Downregulation of transforming growth factor beta receptor II (TGFBR2), but not of signal transducer and activator of transcription 3, in hADSCs showed effects similar to those of miR-21 overexpression. Downregulation of TGFBR2 and overexpression of miR21 decreased tumor vascularity. Inhibition of miR-21 and the addition of TGF-{beta} increased the levels of vascular endothelial growth factor and interleukin-6 in hADSCs. Transplantation of miR-21 inhibitor-transfected hADSCs increased blood flow recovery in a hind limb ischemia model of nude mice, compared with transplantation of control oligo-transfected cells. These findings indicate that MSCs might favor tumor growth in vivo. Thus, it is necessary to study the long-term safety of this technique before MSCs can be used as therapeutic tools in regenerative medicine and tissue engineering.

  13. Targeting miR-21 enhances the sensitivity of human colon cancer HT-29 cells to chemoradiotherapy in vitro

    SciTech Connect

    Deng, Jun; Lei, Wan; Fu, Jian-Chun; Zhang, Ling; Li, Jun-He; Xiong, Jian-Ping

    2014-01-17

    Highlight: MiR-21 plays a significant role in 5-FU resistance. This role might be attributed to targeting of hMSH2 as well as TP and DPD via miR-21 targeted hMSH2. Indirectly targeted TP and DPD to influence 5-FU chemotherapy sensitivity. -- Abstract: 5-Fluorouracil (5-FU) is a classic chemotherapeutic drug that has been widely used for colorectal cancer treatment, but colorectal cancer cells are often resistant to primary or acquired 5-FU therapy. Several studies have shown that miR-21 is significantly elevated in colorectal cancer. This suggests that this miRNA might play a role in this resistance. In this study, we investigated this possibility and the possible mechanism underlying this role. We showed that forced expression of miR-21 significantly inhibited apoptosis, enhanced cell proliferation, invasion, and colony formation ability, promoted G1/S cell cycle transition and increased the resistance of tumor cells to 5-FU and X radiation in HT-29 colon cancer cells. Furthermore, knockdown of miR-21 reversed these effects on HT-29 cells and increased the sensitivity of HT-29/5-FU to 5-FU chemotherapy. Finally, we showed that miR-21 targeted the human mutS homolog2 (hMSH2), and indirectly regulated the expression of thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD). These results demonstrate that miR-21 may play an important role in the 5-FU resistance of colon cancer cells.

  14. miR-502 inhibits cell proliferation and tumor growth in hepatocellular carcinoma through suppressing phosphoinositide 3-kinase catalytic subunit gamma

    SciTech Connect

    Chen, Suling; Li, Fang; Chai, Haiyun; Tao, Xin; Wang, Haili; Ji, Aifang

    2015-08-21

    MicroRNAs (miRNAs) play a key role in carcinogenesis and tumor progression in hepatocellular carcinoma (HCC). In the present study, we demonstrated that miR-502 significantly inhibits HCC cell proliferation in vitro and tumor growth in vivo. G1/S cell cycle arrest and apoptosis of HCC cells were induced by miR-502. Phosphoinositide 3-kinase catalytic subunit gamma (PIK3CG) was identified as a direct downstream target of miR-502 in HCC cells. Notably, overexpression of PIK3CG reversed the inhibitory effects of miR-502 in HCC cells. Our findings suggest that miR-502 functions as a tumor suppressor in HCC via inhibition of PI3KCG, supporting its utility as a promising therapeutic gene target for this tumor type. - Highlights: • miR-502 suppresses HCC cell proliferation in vitro and tumorigenicity in vivo. • miR-502 regulates cell cycle and apoptosis in HCC cells. • PIK3CG is a direct target of miR-502. • miR-502 and PIK3CG expression patterns are inversely correlated in HCC tissues.

  15. RLIP76-dependent suppression of PI3K/AKT/Bcl-2 pathway by miR-101 induces apoptosis in prostate cancer

    SciTech Connect

    Yang, Jing; Song, Qi; Cai, Yi; Wang, Peng; Wang, Min; Zhang, Dong

    2015-08-07

    MicroRNA-101 (miR-101) participates in carcinogenesis and tumor progression in various cancers. However, its biological functions in prostate cancer are still unclear. Here, we demonstrate that miR-101 represents a critical role in regulating cell apoptosis in prostate cancer cells. We first demonstrated that miR-101 treatment promoted apoptosis in DU145 and PC3 cells by using flow cytometric analysis and transmission electron microscopy (TEM). To verify the mechanisms, we identified a novel miR-101 target, Ral binding protein 1 (RLIP76). We found miR-101 transfection significantly suppresses RLIP76 expression, which can transactivate phosphorylation of PI3K-Akt signaling, and resulted in an amplification of Bcl2-induced apoptosis. Furthermore, we demonstrated that RLIP76 overexpression could reverse the anti-tumor effects of miR-101 in DU145 and PC3 cells by using flow cytometry assay and MTT assay. Taken together, our results revealed that the effect of miR-101 on prostate cancer cell apoptosis was due to RLIP76 regulation of the PI3K/Akt/Bcl-2 signaling pathway. - Highlights: • miR-101 inhibited prostate cancer cell proliferation and enhanced apoptosis. • miR-101 directly targeted and regulated RLIP76 expression. • miR-101 suppressed PI3K/Akt/Bcl-2 signaling pathway by targeting RLIP76.

  16. MiR-20a Induces Cell Radioresistance by Activating the PTEN/PI3K/Akt Signaling Pathway in Hepatocellular Carcinoma

    SciTech Connect

    Zhang, Yuqin; Zheng, Lin; Ding, Yi; Li, Qi; Wang, Rong; Liu, Tongxin; Sun, Quanquan; Yang, Hua; Peng, Shunli; Wang, Wei; Chen, Longhua

    2015-08-01

    Purpose: To investigate the role of miR-20a in hepatocellular carcinoma (HCC) cell radioresistance, which may reveal potential strategies to improve treatment. Methods and Materials: The expression of miR-20a and PTEN were detected in HCC cell lines and paired primary tissues by quantitative real-time polymerase chain reaction. Cell radiation combined with colony formation assays was administrated to discover the effect of miR-20a on radiosensitivity. Bioinformatics prediction and luciferase assay were used to identify the target of miR-20a. The phosphatidylinositol 3-kinase inhibitor LY294002 was used to inhibit phosphorylation of Akt, to verify whether miR-20a affects HCC cell radioresistance through activating the PTEN/PI3K/Akt pathway. Results: MiR-20a levels were increased in HCC cell lines and tissues, whereas PTEN was inversely correlated with it. Overexpression of miR-20a in Bel-7402 and SMMC-7721 cells enhances their resistance to the effect of ionizing radiation, and the inhibition of miR-20a in HCCLM3 and QGY-7701 cells sensitizes them to it. PTEN was identified as a direct functional target of miR-20a for the induction of radioresistance. Overexpression of miR-20a activated the PTEN/PI3K/Akt signaling pathway. Additionally, the kinase inhibitor LY294002 could reverse the effect of miR-20a–induced radioresistance. Conclusion: MiR-20a induces HCC cell radioresistance by activating the PTEN/PI3K/Akt pathway, which suggests that miR-20a/PTEN/PI3K/Akt might represent a target of investigation for developing effective therapeutic strategies against HCC.

  17. Demonstration Assessment of LED Roadway Lighting: NE Cully Boulevard Portland, OR

    SciTech Connect

    Royer, Michael P.; Poplawski, Michael E.; Tuenge, Jason R.

    2012-06-29

    A new roadway lighting demonstration project was initiated in late 2010, which was planned in conjunction with other upgrades to NE Cully Boulevard, a residential collector road in the northeast area of Portland, OR. With the NE Cully Boulevard project, the Portland Bureau of Transportation hoped to demonstrate different light source technologies and different luminaires side-by-side. This report documents the initial performance of six different newly installed luminaires, including three LED products, one induction product, one ceramic metal halide product, and one high-pressure sodium (HPS) product that represented the baseline solution. It includes reported, calculated, and measured performance; evaluates the economic feasibility of each of the alternative luminaires; and documents user feedback collected from a group of local Illuminating Engineering Society (IES) members that toured the site. This report does not contain any long-term performance evaluations or laboratory measurements of luminaire performance. Although not all of the installed products performed equally, the alternative luminaires generally offered higher efficacy, more appropriate luminous intensity distributions, and favorable color quality when compared to the baseline HPS luminaire. However, some products did not provide sufficient illumination to all areas—vehicular drive lanes, bicycle lanes, and sidewalks—or would likely fail to meet design criteria over the life of the installation due to expected depreciation in lumen output. While the overall performance of the alternative luminaires was generally better than the baseline HPS luminaire, cost remains a significant barrier to widespread adoption. Based on the cost of the small quantity of luminaires purchased for this demonstration, the shortest calculated payback period for one of the alternative luminaire types was 17.3 years. The luminaire prices were notably higher than typical prices for currently available luminaires

  18. Best Practices Case Study: Urbane Homes - Crestwood, KY, Various Locations, Greater Louisville, KY

    SciTech Connect

    2011-09-01

    Case study of Urbane Homes, who worked with Building America to build market rate homes with HERS scores of 57 to 62. Despite a down market they’ve sold every home within 3 weeks of listing, without any advertising.

  19. MiR-145 is downregulated in human ovarian cancer and modulates cell growth and invasion by targeting p70S6K1 and MUC1

    SciTech Connect

    Wu, Huijuan; Xiao, ZhengHua; Wang, Ke; Liu, Wenxin; Hao, Quan

    2013-11-29

    Highlights: •MiR-145 is downregulated in human ovarian cancer. •MiR-145 targets p70S6K1 and MUC1. •p70S6K1 and MUC1 are involved in miR-145 mediated tumor cell growth and cell invasion, respectively. -- Abstract: MicroRNAs (miRNAs) are a family of small non-coding RNA molecules that regulate gene expression at post-transcriptional levels. Previous studies have shown that miR-145 is downregulated in human ovarian cancer; however, the roles of miR-145 in ovarian cancer growth and invasion have not been fully demonstrated. In the present study, Northern blot and qRT-PCR analysis indicate that miR-145 is downregulated in ovarian cancer tissues and cell lines, as well as in serum samples of ovarian cancer, compared to healthy ovarian tissues, cell lines and serum samples. Functional studies suggest that miR-145 overexpression leads to the inhibition of colony formation, cell proliferation, cell growth viability and invasion, and the induction of cell apoptosis. In accordance with the effect of miR-145 on cell growth, miR-145 suppresses tumor growth in vivo. MiR-145 is found to negatively regulate P70S6K1 and MUC1 protein levels by directly targeting their 3′UTRs. Importantly, the overexpression of p70S6K1 and MUC1 can restore the cell colony formation and invasion abilities that are reduced by miR-145, respectively. MiR-145 expression is increased after 5-aza-CdR treatment, and 5-aza-CdR treatment results in the same phenotype as the effect of miR-145 overexpression. Our study suggests that miR-145 modulates ovarian cancer growth and invasion by suppressing p70S6K1 and MUC1, functioning as a tumor suppressor. Moreover, our data imply that miR-145 has potential as a miRNA-based therapeutic target for ovarian cancer.

  20. AmeriFlux US-Ne1 Mead - irrigated continuous maize site

    DOE Data Explorer

    Suyker, Andy [University of Nebraska - Lincoln

    2016-01-01

    This is the AmeriFlux version of the carbon flux data for the site US-Ne1 Mead - irrigated continuous maize site. Site Description - The study site is one of three fields (all located within 1.6 km of each other) at the University of Nebraska Agricultural Research and Development Center near Mead, Nebraska. This site is irrigated with a center pivot system. Prior to the initiation of the study, the irrigated site had a 10-yr history of maize-soybean rotation under no-till. A tillage operation (disking) was done just prior to the 2001 planting to homogenize the top 0.1 m of soil, incorporate P and K fertilizers, as well as previously accumulated surface residues. Since the tillage operation, the site has been under no-till management until the harvest of 2005. Following harvest, a conservation-plow tillage operation was initiated where a small amount of N fertilizer is sprayed on the residue immediately prior to the plow operation. Approximately 1/3 of the crop residue is left on the surface. The post-harvest conservation-plow operation continues as the current practice.

  1. Preparation of state purified beams of He, Ne, C, N, and O atoms

    SciTech Connect

    Jankunas, Justin; Reisyan, Kevin S.; Osterwalder, Andreas

    2015-03-14

    The production and guiding of ground state and metastable C, N, and O atoms in a two-meter-long, bent magnetic guide are described. Pure beams of metastable He({sup 3}S{sub 1}) and Ne({sup 3}P{sub 2}), and of ground state N({sup 4}S{sub 3/2}) and O({sup 3}P{sub 2}) are obtained using an Even-Lavie valve paired with a dielectric barrier discharge or electron bombardment source. Under these conditions no electronically excited C, N, or O atoms are observed at the exit of the guide. A general valve with electron impact excitation creates, in addition to ground state atoms, electronically excited C({sup 3}P{sub 2}; {sup 1}D{sub 2}) and N({sup 2}D{sub 5/2}; {sup 2}P{sub 3/2}) species. The two experimental conditions are complimentary, demonstrating the usefulness of a magnetic guide in crossed or merged beam experiments such as those described in Henson et al. [Science 338, 234 (2012)] and Jankunas et al. [J. Chem. Phys. 140, 244302 (2014)].

  2. Influence of Mesozoic age structure on Miocene tectonic development in NE Anzoategui, Eastern Venezuela Basin

    SciTech Connect

    Sadler, P.; White, S.

    1996-08-01

    Structure within and surrounding the Quiamare-La Ceiba region, Eastern Venezuela Basin, is dominated by two major thrust fault systems. They were generated during Early-Middle Miocene time in response to oblique convergence of the Caribbean and South American plates. They are. respectively, the SE vergent NE-SW oriented Anaco fault system, and the SSE vergent ENE-WSW oriented Pirital fault system. The major structural feature associated with each fault system is a basement cored ramp anticline. New seismic data provides evidence that contributes to a better understanding of the sequence of tectonic development within and surrounding the Quiamare-La Ceiba region. Compressional structures in both the hanging wall and the footwall of the Pirital fault system appear to be inverted normal faults, that were previously active during Mesozoic time along the northern South America passive margin. A conjugate set of strike-slip faults is also present. They are oriented NNW-SSE, parallel to the Urica lineation, and SSW-NNE, respectively. A Mesozoic origin for these faults is suggested. Post-compressional relaxation during Plio-Pleistocene time resulted in the development of shallow, small scale normal faults. These normal faults appear to be localized by structural adjustments along the strike-slip fault sets. Existing oil and gas production within the Quiamare-La Ceiba region is from localized structural closures. Strike-slip faults dissect the prevailing structural grain, and may provide an additional hydrocarbon trapping mechanism.

  3. High Level Requirements for the Nuclear Energy -- Knowledge Base for Advanced Modeling and Simulation (NE-KAMS)

    SciTech Connect

    Rich Johnson; Hyung Lee; Kimberlyn C. Mousseau

    2011-09-01

    The US Department of Energy, Office of Nuclear Energy (DOE-NE), has been tasked with the important mission of ensuring that nuclear energy remains a compelling and viable energy source in the U.S. The motivations behind this mission include cost-effectively meeting the expected increases in the power needs of the country, reducing carbon emissions and reducing dependence on foreign energy sources. In the near term, to ensure that nuclear power remains a key element of U.S. energy strategy and portfolio, the DOE-NE will be working with the nuclear industry to support safe and efficient operations of existing nuclear power plants. In the long term, to meet the increasing energy needs of the U.S., the DOE-NE will be investing in research and development (R&D) and working in concert with the nuclear industry to build and deploy new, safer and more efficient nuclear power plants. The safe and efficient operations of existing nuclear power plants and designing, licensing and deploying new reactor designs, however, will require focused R&D programs as well as the extensive use and leveraging of advanced modeling and simulation (M&S). M&S will play a key role in ensuring safe and efficient operations of existing and new nuclear reactors. The DOE-NE has been actively developing and promoting the use of advanced M&S in reactor design and analysis through its R&D programs, e.g., the Nuclear Energy Advanced Modeling and Simulation (NEAMS) and Consortium for Advanced Simulation of Light Water Reactors (CASL) programs. Also, nuclear reactor vendors are already using CFD and CSM, for design, analysis, and licensing. However, these M&S tools cannot be used with confidence for nuclear reactor applications unless accompanied and supported by verification and validation (V&V) and uncertainty quantification (UQ) processes and procedures which provide quantitative measures of uncertainty for specific applications. The Nuclear Energy Knowledge base for Advanced Modeling and Simulation

  4. Study of scintillation, fluorescence and scattering in mineral oil for the MiniBooNE neutrino detector

    SciTech Connect

    Brown, Bruce C.; Brice, Stephen; Hawker, Eric; Maza, Shannon; Meyer, Hans-Otto; Pla-Dalmau, Anna; Tayloe, Rex; Tanaka, Hirohisa A.; Toptygin, Dmitri; /Fermilab /Western Illinois U. /Indiana U. /Princeton U. /Johns Hopkins U.

    2004-11-01

    The MiniBooNE neutrino detector at Fermilab (FNAL) is filled with 250,000 gallons of pure mineral oil. The principal signal for MiniBooNE is light observed in a prompt Cherenkov cone. Scattering and fluorescence modify our detection of this light. Scintillation is also created by ionization in the oil. Studies of fluorescence of this oil have been carried out over a wide spectrum of exciting light and time resolved fluorescence with a narrower range of excitation. Polarized scattering measurements have been carried out at longer wavelengths. Time resolved and spectrally resolved scintillation has been studied with a 200 MeV Proton beam at the Indiana University Cyclotron Facility. Results of these studies will be reported.

  5. Proposal of a new generation of Laser Beacon for time calibration in the KM3NeT neutrino telescope

    SciTech Connect

    Real, Diego [IFIC, Instituto de Fsica Corpuscular, CSIC-Universidad de Valencia, C Collaboration: KM3NeT Collaboration

    2014-11-18

    The KM3NeT collaboration aims at the construction of a multi-km3 high-energy neutrino telescope in the Mediterranean Sea consisting of a matrix of pressure resistant glass spheres holding each a set (31) of small area photomultipliers. The main motivation of the telescope is to observe cosmic neutrinos through the Cherenkov light induced in sea water by charged particles produced in neutrino interactions with the surrounding medium. A relative time calibration between photomultipliers of the order of 1 ns is required to achieve an optimal performance. To this end, several time calibration subsystems have been developed. In this article, the proposal of a last generation Laser Beacon, to be used in KM3NeT and developed to measure and monitor the relative time offsets between photomultipliers, is presented.

  6. Nus and anti-nus from MiniBooNE: searching for the shadow of the ghost

    SciTech Connect

    Mills, Geoffrey B

    2009-01-01

    The latest results from MiniBooNE, the short baseline neutrino experiment operating on the 8 GeV booster's neutrino beam line (the BNB) at Fermilab, are discussed. The standard three active generation model of neutrino oscillations is now grounded firmly by experimental data. Studying the properties of neutrinos at the few percent level and below may uncover new properties of neutrinos and their oscillations and provide a path to physics beyond the standard neutrino model.

  7. Rotational and angular distributions of NO products from NO-Rg(Rg = He, Ne, Ar) complex photodissociation

    DOE PAGES [OSTI]

    Heather L. Holmes-Ross; Hall, Gregory E.; Valenti, Rebecca J.; Yu, Hua -Gen; Lawrance, Warren D.

    2016-01-29

    In this study, we present the results of an investigation into the rotational and angular distributions of the NO A~ state fragment following photodissociation of the NO-He, NO-Ne and NO-Ar van der Waals complexed excited via the A~ ← X~ transition. For each complex the dissociation is probed for several values of Ea, the available energy above the dissociation threshold.

  8. The long non-coding RNA H19-derived miR-675 modulates human gastric cancer cell proliferation by targeting tumor suppressor RUNX1

    SciTech Connect

    Zhuang, Ming; Gao, Wen; Xu, Jing; Wang, Ping; Shu, Yongqian

    2014-06-06

    Graphical abstract: - Highlights: • H19 regulates gastric cancer cell proliferation phenotype via miR-675. • MiR-675 modulates cell proliferation of gastric cancer cells by targeting tumor suppressor RUNX1. • The H19/miR-675/RUNX1 axis plays an important role in the tumorigenesis of gastric cancer. - Abstract: The lncRNA H19 has been recently shown to be upregulated and play important roles in gastric cancer tumorigenesis. However, the precise molecular mechanism of H19 and its mature product miR-675 in the carcinogenesis of gastric cancer remains unclear. In this study, we found that miR-675 was positively expressed with H19 and was a pivotal mediator in H19-induced gastric cancer cell growth promotion. Subsequently, the tumor suppressor Runt Domain Transcription Factor1 (RUNX1) was confirmed to be a direct target of miR-675 using a luciferase reporter assay and Western blotting analyses. A series of rescue assays indicated that RUNX1 mediated H19/miR-67-induced gastric cancer cell phenotypic changes. Moreover, the inverse relationship between the expression of RUNX1 and H19/miR-675 was also revealed in gastric cancer tissues and gastric cancer cell lines. Taken together, our study demonstrated that the novel pathway H19/miR-675/RUNX1 regulates gastric cancer development and may serve as a potential target for gastric cancer therapy.

  9. A measurement of the neutral current neutrino-nucleon elastic cross section at MiniBooNE

    SciTech Connect

    Cox, David Christopher; /Indiana U.

    2008-02-01

    The neutral current neutrino-nucleon elastic interaction {nu} N {yields} {nu} N is a fundamental process of the weak interaction ideally suited for characterizing the structure of the nucleon neutral weak current. This process comprises {approx}18% of neutrino events in the neutrino oscillation experiment, MiniBooNE, ranking it as the experiment's third largest process. Using {approx}10% of MiniBooNE's available neutrino data, a sample of these events were identified and analyzed to determine the differential cross section as a function of the momentum transfer of the interaction, Q{sup 2}. This is the first measurement of a differential cross section with MiniBooNE data. From this analysis, a value for the nucleon axial mass M{sub A} was extracted to be 1.34 {+-} 0.25 GeV consistent with previous measurements. The integrated cross section for the Q{sup 2} range 0.189 {yields} 1.13 GeV{sup 2} was calculated to be (8.8 {+-} 0.6(stat) {+-} 0.2(syst)) x 10{sup -40} cm{sup 2}.

  10. Testing CPT conservation using the NuMI neutrino beam with the MINOS experiment

    SciTech Connect

    Auty, David John

    2010-05-01

    The MINOS experiment was designed to measure neutrino oscillation parameters with muon neutrinos. It achieves this by measuring the neutrino energy spectrum and flavor composition of the man-made NuMI neutrino beam 1km after the beam is formed and again after 735 km. By comparing the two spectra it is possible to measure the oscillation parameters. The NuMI beam is made up of 7.0% {bar {nu}}{sub {mu}}, which can be separated from the {nu}{sub {mu}} because the MINOS detectors are magnetized. This makes it possible to study {bar {nu}}{sub {mu}} oscillations separately from those of muon neutrinos, and thereby test CPT invariance in the neutrino sector by determining the {bar {nu}}{sub {mu}} oscillation parameters and comparing them with those for {nu}{sub {mu}}, although any unknown physics of the antineutrino would appear as a difference in oscillation parameters. Such a test has not been performed with beam {bar {nu}}{sub {mu}} before. It is also possible to produce an almost pure {bar {nu}}{sub {mu}} beam by reversing the current through the magnetic focusing horns of the NuMI beamline, thereby focusing negatively, instead of positively charged particles. This thesis describes the analysis of the 7% {bar {nu}}{sub {mu}} component of the forward horn current NuMI beam. The {bar {nu}}{sub {mu}} of a data sample of 3.2 x 10{sup 20} protons on target analysis found 42 events, compared to a CPT conserving prediction of 58.3{sub -7.6}{sup +7.6}(stat.){sub -3.6}{sup +3.6}(syst.) events. This corresponds to a 1.9 {sigma} deficit, and a best fit value of {Delta}{bar m}{sub 32}{sup 2} = 18 x 10{sup -3} eV{sup 2} and sin{sup 2} 2{bar {theta}}{sub 23} = 0.55. This thesis focuses particularly on the selection of {bar {nu}}{sub {mu}} events, and investigates possible improvements of the selection algorithm. From this a different selector was chosen, which corroborated the findings of the original selector. The thesis also investigates how the systematic errors affect the

  11. ,"Detroit, MI Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Detroit, MI Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  12. ,"Marysville, MI Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Marysville, MI Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  13. Port Huron, MI Natural Gas Pipeline Imports From Canada (Dollars per

    Energy Information Administration (EIA) (indexed site)

    Thousand Cubic Feet) Dollars per Thousand Cubic Feet) Port Huron, MI Natural Gas Pipeline Imports From Canada (Dollars per Thousand Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2016 2.07 2.06 2.21 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Price of

  14. ,"St. Clair, MI Natural Gas Pipeline Exports to Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Exports to Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","St. Clair, MI Natural Gas Pipeline Exports to Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  15. ,"St. Clair, MI Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","St. Clair, MI Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  16. Monte Carlo calculations for reference dosimetry of electron beams with the PTW Roos and NE2571 ion chambers

    SciTech Connect

    Muir, B. R. Rogers, D. W. O.

    2013-12-15

    Purpose: To investigate recommendations for reference dosimetry of electron beams and gradient effects for the NE2571 chamber and to provide beam quality conversion factors using Monte Carlo simulations of the PTW Roos and NE2571 ion chambers. Methods: The EGSnrc code system is used to calculate the absorbed dose-to-water and the dose to the gas in fully modeled ion chambers as a function of depth in water. Electron beams are modeled using realistic accelerator simulations as well as beams modeled as collimated point sources from realistic electron beam spectra or monoenergetic electrons. Beam quality conversion factors are calculated with ratios of the doses to water and to the air in the ion chamber in electron beams and a cobalt-60 reference field. The overall ion chamber correction factor is studied using calculations of water-to-air stopping power ratios. Results: The use of an effective point of measurement shift of 1.55 mm from the front face of the PTW Roos chamber, which places the point of measurement inside the chamber cavity, minimizes the difference betweenR{sub 50}, the beam quality specifier, calculated from chamber simulations compared to that obtained using depth-dose calculations in water. A similar shift minimizes the variation of the overall ion chamber correction factor with depth to the practical range and reduces the root-mean-square deviation of a fit to calculated beam quality conversion factors at the reference depth as a function of R{sub 50}. Similarly, an upstream shift of 0.34 r{sub cav} allows a more accurate determination of R{sub 50} from NE2571 chamber calculations and reduces the variation of the overall ion chamber correction factor with depth. The determination of the gradient correction using a shift of 0.22 r{sub cav} optimizes the root-mean-square deviation of a fit to calculated beam quality conversion factors if all beams investigated are considered. However, if only clinical beams are considered, a good fit to results for

  17. Microsoft Word - figure_14.doc

    Energy Information Administration (EIA) (indexed site)

    42 Figure 14. Net interstate movements, imports, and exports of natural gas in the United States, 2015 (million cubic feet) Norway Trinidad/ Tobago Yemen Norway Egypt Turkey Interstate Movements Not Shown on Map From Volume To From Volume To CT RI MD DC IN MA MD VA MA CT RI MA MA NH VA DC WA MT ID OR W Y ND SD CA NV UT CO NE KS AZ NM OK TX MN WI MI IA IL IN OH MO AR MS AL GA TN KY FL SC NC WV MD DE VA PA NJ NY CT RI MA VT NH ME LA HI AK Mexico Canada Canada Canada Canada Canada Canada Canada

  18. panchenko(1)-99.PDF

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    FL PADD 4: Rocky Mountain PADD 5: West Coast PADD 2: Midwest PADD 1: East Coast PADD 3: Gulf Coast PADD1A: New England PADD1B: Central Atlantic PADD1C: Lower Atlantic Petroleum Administration for Defense Districts AK HI WA OR CA NV AZ MT WY CO UT ID ND SD NE KS OK MO MN WI MI IL IN OH KY TN IA NM TX AR LA AL MS WV VA NC SC GA FL ME NH VT NY PA NJ MD DE MA CT RI

    Diurnal Behavior of Aerosol and Water Vapor in Summer M. V. Panchenko, S. M. Sakerin, D. M. Kabanov, S. A. Terpugova Institute of

  19. Petroleum Marketing Monthly

    Energy Information Administration (EIA) (indexed site)

    Prices U.S. Energy Information Administration | Petroleum Marketing Monthly Table 18. Domes c crude oil fi rst purchase prices dollars per barrel Year month U.S. Average PAD District 1 PAD District 2 U.S. Average Less AK North Slope Average NY PA WV Average IL IN KS KY MI NE 1996 18.46 19.41 20.82 20.95 20.99 19.59 20.33 20.86 20.67 20.47 20.24 20.32 19.57 1997 17.23 17.92 19.25 18.49 18.79 17.56 18.60 19.11 18.73 18.63 17.97 18.75 18.10 1998 10.87 11.51 13.21 13.66 13.67 11.95 12.29 12.78 12.49

  20. Word Pro - Untitled1

    Energy Information Administration (EIA) (indexed site)

    State-Level Energy Consumption Estimates and Estimated Consumption per Capita, 2010 Consumption Consumption per Capita 14 U.S. Energy Information Administration / Annual Energy Review 2011 TX CA FL LA IL OH PA NY GA IN MI NC VA NJ TN WA KY AL MO MN WI SC OK CO IA MD AZ MA MS KS AR OR NE UT CT WV NM NV AK WY ID ND ME MT SD NH HI DE RI DC VT 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 0 2 4 6 8 10

  1. Assessment of radiological releases from the NuMI facility during MINOS and NOvA operations

    SciTech Connect

    Martens, Mike; /Fermilab

    2007-04-01

    This report makes projections of the radiological releases from the NuMI facility during operations for the MINOS and NO ?A experiments. It includes an estimate of the radionuclide levels released into the atmosphere and the estimated tritium and sodium-22 concentrations in the NuMI sump water and Fermilab pond system. The analysis was performed for NuMI operations with a beam power on target increased from the present 400 kW design up to a possible 1500 kW with future upgrades. The total number of protons on target was assumed to be 18 x 10{sup 20} after the completion of MINOS and 78 x 10{sup 20} after the completion of NO ?A.

  2. Identification of miR-2400 gene as a novel regulator in skeletal muscle satellite cells proliferation by targeting MYOG gene

    SciTech Connect

    Zhang, Wei Wei; Tong, Hui Li; Sun, Xiao Feng; Hu, Qian; Yang, Yu; Li, Shu Feng; Yan, Yun Qin; Li, Guang Peng

    2015-08-07

    MicroRNAs play critical roles in skeletal muscle development as well as in regulation of muscle cell proliferation and differentiation. Previous study in our laboratory showed that the expression level of miR-2400, a novel and unique miRNA from bovine, had significantly changed in skeletal muscle-derived satellite cells (MDSCs) during differentiation, however, the function and expression pattern for miR-2400 in MDSCs has not been fully understood. In this report, we firstly identified that the expression levels of miR-2400 were down-regulated during MDSCs differentiation by stem-loop RT-PCR. Over-expression and inhibition studies demonstrated that miR-2400 promoted MDSCs proliferation by EdU (5-ethynyl-2′ deoxyuridine) incorporation assay and immunofluorescence staining of Proliferating cell nuclear antigen (PCNA). Luciferase reporter assays showed that miR-2400 directly targeted the 3′ untranslated regions (UTRs) of myogenin (MYOG) mRNA. These data suggested that miR-2400 could promote MDSCs proliferation through targeting MYOG. Furthermore, we found that miR-2400, which was located within the eighth intron of the Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) gene, was down-regulated in MDSCs in a direct correlation with the WHSC1L1 transcript by Clustered regularly interspaced palindromic repeats interference (CRISPRi). In addition, these observations not only provided supporting evidence for the codependent expression of intronic miRNAs and their host genes in vitro, but also gave insight into the role of miR-2400 in MDSCs proliferation. - Highlights: • miR-2400 is a novel and unique miRNA from bovine. • miR-2400 could promote skeletal muscle satellite cells proliferation. • miR-2400 directly targeted the 3′ untranslated regions of MYOG mRNA. • miR-2400 could be coexpressed together with its host gene WHSC1L1.

  3. miR-340 inhibits glioblastoma cell proliferation by suppressing CDK6, cyclin-D1 and cyclin-D2

    SciTech Connect

    Li, Xuesong; Gong, Xuhai; Chen, Jing; Zhang, Jinghui; Sun, Jiahang; Guo, Mian

    2015-05-08

    Glioblastoma development is often associated with alteration in the activity and expression of cell cycle regulators, such as cyclin-dependent kinases (CKDs) and cyclins, resulting in aberrant cell proliferation. Recent studies have highlighted the pivotal roles of miRNAs in controlling the development and growth of glioblastoma. Here, we provide evidence for a function of miR-340 in the inhibition of glioblastoma cell proliferation. We found that miR-340 is downregulated in human glioblastoma tissue samples and several established glioblastoma cell lines. Proliferation and neurosphere formation assays revealed that miR-340 plays an oncosuppressive role in glioblastoma, and that its ectopic expression causes significant defect in glioblastoma cell growth. Further, using bioinformatics, luciferase assay and western blot, we found that miR-340 specifically targets the 3′UTRs of CDK6, cyclin-D1 and cyclin-D2, leading to the arrest of glioblastoma cells in the G0/G1 cell cycle phase. Confirming these results, we found that re-introducing CDK6, cyclin-D1 or cyclin-D2 expression partially, but significantly, rescues cells from the suppression of cell proliferation and cell cycle arrest mediated by miR-340. Collectively, our results demonstrate that miR-340 plays a tumor-suppressive role in glioblastoma and may be useful as a diagnostic biomarker and/or a therapeutic avenue for glioblastoma. - Highlights: • miR-340 is downregulated in glioblastoma samples and cell lines. • miR-340 inhibits glioblastoma cell proliferation. • miR-340 directly targets CDK6, cyclin-D1, and cyclin-D2. • miR-340 regulates glioblastoma cell proliferation via CDK6, cyclin-D1 and cyclin-D2.

  4. shaleusa5.pdf

    Gasoline and Diesel Fuel Update

    ... NY PA NJ OH DC DE WV MD KY VA NC TN SC MI CANADA 2 0 0 1 0 0 Marcellus Shale Gas Play, Appalachian Basin Source: US Energy Information Administration based on data from WVGES , PA ...

  5. ,"Sault St Marie, MI Natural Gas Pipeline Exports to Canada (Million Cubic Feet)"

    Energy Information Administration (EIA) (indexed site)

    Sault St Marie, MI Natural Gas Pipeline Exports to Canada (Million Cubic Feet)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Sault St Marie, MI Natural Gas Pipeline Exports to Canada (Million Cubic Feet)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release

  6. Category:Utility Rate Impacts on PV Economics By Location | Open...

    OpenEI (Open Energy Information) [EERE & EIA]

    MI Traverse City, MI International Falls, MN Minneapolis, MN Kansas City, MO Jackson, MS Billings, MT Greensboro, NC Wilmington, NC Bismarck, ND Minot, ND Omaha, NE...

  7. miR-206 is down-regulated in breast cancer and inhibits cell proliferation through the up-regulation of cyclinD2

    SciTech Connect

    Zhou, Jing; Tian, Ye; Li, Juan; Lu, Binbin; Sun, Ming; Zou, Yanfen; Kong, Rong; Luo, Yanhong; Shi, Yongguo; Wang, Keming; Ji, Guozhong

    2013-04-05

    Highlights: ? miR-206 was downexpressed in tumor samples compared with matched normal samples. ? Enhanced expression of miR-206 could inhibit breast cancer growth in vitro. ? Luciferase confirmed miR-206 functions as an anti-oncogene by targeting cyclinD2. ? A reverse correlation between miR-206 and cyclinD2 in breast cancer was found. -- Abstract: MicroRNAs act as important gene regulators in human genomes, and their aberrant expression is linked to many malignancies. Aberrant expression of miR-206 has been frequently reported in cancer studies; however, the role and mechanism of its function in breast cancer remains unclear. Quantitative real-time PCR was performed to detect the relative expression levels of miR-206 in breast cancer and normal breast tissues. Lower expression of miR-206 in breast cancer tissues was associated with larger tumour size and a more advanced clinical stage. Further in vitro observations showed that the enforced expression of miR-206 in MCF-7 breast cancer cells inhibited cell growth by blocking the G1/S transition and suppressed cell proliferation and colony formation, implying that miR-206 functions as a tumour suppressor in the progression of breast cancer. Interestingly, Luciferase assays first revealed that miR-206 inhibited cyclinD2 expression by targeting two binding sites in the 3?-untranslated region of cyclinD2 mRNA. qRT-PCR and Western blot assays verified that miR-206 reduced cyclinD2 expression at both the mRNA and protein levels. A reverse correlation between miR-206 and cyclinD2 expression was noted in breast cancer tissues. Altogether, our results identify a crucial tumour suppressive role of miR-206 in the progression of breast cancer, at least partly via up-regulation of the expression of cyclinD2, and suggest that miR-206 might be a candidate prognostic predictor or an anticancer therapeutic target for breast cancer patients.

  8. MiR-138 promotes smooth muscle cells proliferation and migration in db/db mice through down-regulation of SIRT1

    SciTech Connect

    Xu, Juan; Li, Li; Yun, Hui-fang; Han, Ye-shan

    2015-08-07

    Background: Diabetic vascular smooth muscle cells (VSMCs) exhibit significantly increased rates of proliferation and migration, which was the most common pathological change in atherosclerosis. In addition, the study about the role for miRNAs in the regulation of VSMC proliferation is just beginning to emerge and additional miRNAs involved in VSMC proliferation modulation should be identified. Methods: The expression of miR-138 and SIRT1 were examined in SMCs separated from db/db mice and in SMC lines C-12511 exposed to high glucose with qRT-PCR and western blot. The regulation of miR-138 on the expression of SMCs was detected with luciferase report assay. VSMCs proliferation and migration assays were performed to examine the effect of miR-138 inhibitor on VSMCs proliferation and migration. Results: We discovered that higher mRNA level of miR-138 and reduced expression of SIRT1 were observed in SMCs separated from db/db mice and in SMC lines C-12511. Moreover, luciferase report assay showed that the activity of SIRT1 3′-UTR was highly increased by miR-138 inhibitor and reduced by miR-138 mimic. In addition, we examined that the up-regulation of NF-κB induced by high glucose in SMCs was reversed by resveratrol and miR-138 inhibitor. MTT and migration assays showed that miR-138 inhibitor attenuated the proliferation and migration of smooth muscle cells. Conclusion: In this study, we revealed that miR-138 might promote proliferation and migration of SMC in db/db mice through suppressing the expression of SIRT1. - Highlights: • Higher mRNA level of miR-138 was observed in SMCs from db/db mice. • The mRNA and protein level of SIRT1 in SMCs from db/db mice were greatly reduced. • miR-138 could regulate the expression of SIRT1 in SMCs. • SIRT1 overexpression reversed the up-regulation of acetylized p65 and NF-κB induced by high glucose. • MiR-138 inhibitor reversed VSMCs proliferation and migration induced by high glucose.

  9. Angular momentum exchange by gravitational torques and infall in the circumbinary disk of the protostellar system L1551 NE

    SciTech Connect

    Takakuwa, Shigehisa; Ho, Paul T. P. [Academia Sinica Institute of Astronomy and Astrophysics, P.O. Box 23-141, Taipei 10617, Taiwan (China); Saito, Masao [Joint ALMA Observatory, Ave. Alonso de Cordova 3107, Vitacura, Santiago (Chile); Saigo, Kazuya [ALMA Project Office, National Astronomical Observatory of Japan, Osawa 2-21-1, Mitaka, Tokyo 181-8588 (Japan); Matsumoto, Tomoaki [Faculty of Humanity and Environment, Hosei University, Chiyoda-ku, Tokyo 102-8160 (Japan); Lim, Jeremy [Department of Physics, University of Hong Kong, Pokfulam Road (Hong Kong); Hanawa, Tomoyuki, E-mail: takakuwa@asiaa.sinica.edu.tw [Center for Frontier Science, Chiba University, Inage-ku, Chiba 263-8522 (Japan)

    2014-11-20

    We report an ALMA observation of the Class I binary protostellar system L1551 NE in the 0.9 mm continuum, C{sup 18}O (3-2), and {sup 13}CO (3-2) lines at a ?1.6 times higher resolution and a ?6 times higher sensitivity than those of our previous SubMillimeter Array (SMA) observations, which revealed a r ? 300 AU scale circumbinary disk in Keplerian rotation. The 0.9 mm continuum shows two opposing U-shaped brightenings in the circumbinary disk and exhibits a depression between the circumbinary disk and the circumstellar disk of the primary protostar. The molecular lines trace non-axisymmetric deviations from Keplerian rotation in the circumbinary disk at higher velocities relative to the systemic velocity, where our previous SMA observations could not detect the lines. In addition, we detect inward motion along the minor axis of the circumbinary disk. To explain the newly observed features, we performed a numerical simulation of gas orbits in a Roche potential tailored to the inferred properties of L1551 NE. The observed U-shaped dust features coincide with locations where gravitational torques from the central binary system are predicted to impart angular momentum to the circumbinary disk, producing shocks and hence density enhancements seen as a pair of spiral arms. The observed inward gas motion coincides with locations where angular momentum is predicted to be lowered by the gravitational torques. The good agreement between our observation and model indicates that gravitational torques from the binary stars constitute the primary driver for exchanging angular momentum so as to permit infall through the circumbinary disk of L1551 NE.

  10. miR-15a/16 Enhances Radiation Sensitivity of Non-Small Cell Lung Cancer Cells by Targeting the TLR1/NF-κB Signaling Pathway

    SciTech Connect

    Lan, Fengming; Yue, Xiao; Ren, Gang; Li, Hongqi; Ping, Li; Wang, Yingjie; Xia, Tingyi

    2015-01-01

    Purpose: Many miRNAs have been identified as essential issues and core determining factors in tumor radiation. Recent reports have demonstrated that miRNAs and Toll-like receptors could exert reciprocal effects to control cancer development in various ways. However, a novel role of miR-15a/16 in enhancing radiation sensitivity by directly targeting TLR1 has not been reported, to our knowledge. Methods and Materials: Bioinformatic analyses, luciferase reporter assay, biochemical assays, and subcutaneous tumor establishment were used to characterize the signaling pathways of miRNA-15a/16 in response to radiation treatment. Results: First, an inverse correlation between the expression of miR-15a/16 and TLR1 protein was revealed in non-small cell lung cancer (NSCLC) and normal lung tissues. Next, we corroborated that miR-15a/16 specifically bound to TLR1 3′UTR and inhibited the expression of TLR1 in H358 and A549 cells. Furthermore, miR-15a/16 downregulated the activity of the NF-κB signaling pathway through TLR1. In addition, overexpression of miR-15a/16 inhibited survival capability and increased radiation-induced apoptosis, resulting in enhancement of radiosensitivity in H358 and A549 cells. Finally, subcutaneous tumor bearing NSCLC cells in a nude mice model was established, and the results showed that combined groups (miR-15a/16 + radiation) inhibited tumor growth more significantly than did radiation alone. Conclusions: We mainly elucidate that miRNA-15a/16 can enhance radiation sensitivity by regulating the TLR1/NF-κB signaling pathway and act as a potential therapeutic approach to overcome radioresistance for lung cancer treatment.

  11. Quantum dynamics of solid Ne upon photo-excitation of a NO impurity: A Gaussian wave packet approach

    SciTech Connect

    Unn-Toc, W.; Meier, C.; Halberstadt, N.; Uranga-Pina, Ll.; Rubayo-Soneira, J.

    2012-08-07

    A high-dimensional quantum wave packet approach based on Gaussian wave packets in Cartesian coordinates is presented. In this method, the high-dimensional wave packet is expressed as a product of time-dependent complex Gaussian functions, which describe the motion of individual atoms. It is applied to the ultrafast geometrical rearrangement dynamics of NO doped cryogenic Ne matrices after femtosecond laser pulse excitation. The static deformation of the solid due to the impurity as well as the dynamical response after femtosecond excitation are analyzed and compared to reduced dimensionality studies. The advantages and limitations of this method are analyzed in the perspective of future applications to other quantum solids.

  12. Transfer mechanism in /sup 16/O+/sup 24/Mg and /sup 20/Ne+/sup 24/Mg elastic scattering

    SciTech Connect

    NING Ping-Zhi; GAO Cheng-Qun; HE Guo-Zhu

    1985-10-01

    The mechanism of transferring a cluster of nucleons between two colliding nuclei is considered to explain the backward angle oscillatory rise in the differential cross section of the elastic scattering between certain nuclei, such as /sup 16/O+/sup 24/Mg or /sup 20/Ne+/sup 24/Mg. The nuclear molecular orbit approximation theory is applied. For one-step transfer, if the parameter involved is assumed to be adjustable, the numerical calculations can be made to fit the experimental results naturally.

  13. St. Clair, MI Natural Gas Pipeline Imports From Canada (Million Cubic Feet)

    Energy Information Administration (EIA) (indexed site)

    Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 14,132 11,855 34,592 33,388 2000's 17,198 21,747 28,441 5,202 22,853 18,281 10,410 9,633 9,104 6,544 2010's 5,591 5,228 3,531 6,019 16,409 9,024 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Natural Gas Pipeline Imports by Point of Entry St. Clair, MI Natural

  14. Observation of Disappearance of Muon Neutrinos in the NuMI Beam

    SciTech Connect

    Pavlovic, Zarko

    2008-05-01

    The Main Injector Neutrino Oscillation Search (MINOS) is a two detector long-baseline neutrino experiment designed to study the disappearance of muon neutrinos. MINOS will test the vμ → vτ oscillation hypothesis and measure precisely Δm232 and sin223 oscillation parameters. The source of neutrinos for MINOS experiment is Fermilab's Neutrinos at the Main Injector (NuMI) beamline. The energy spectrum and the composition of the beam is measured at two locations, one close to the source and the other 735 km down-stream in the Soudan Mine Underground Laboratory in northern Minnesota. The precision measurement of the oscillation parameters requires an accurate prediction of the neutrino flux at the Far Detector. This thesis discusses the calculation of the neutrino flux at the Far Detector and its uncertainties. A technique that uses the Near Detector data to constrain the uncertainties in the calculation of the flux is described. The data corresponding to an exposure of 2.5 x 1020 protons on the NuMI target is presented and an energy dependent disappearance pattern predicted by neutrino oscillation hypotheses is observed in the Far Detector data. The fit to MINOS data, for given exposure, yields the best fit values for Δm$2\\atop{23}$ and sin223 to be (2.38$+0.20\\atop{-0.16}$) x 10-3 eV2/c4and 1.00-0.08, respectively.

  15. Validation of the MCNPX-PoliMi Code to Design a Fast-Neutron Multiplicity Counter

    SciTech Connect

    J. L. Dolan; A. C. Kaplan; M. Flaska; S. A. Pozzi; D. L. Chichester

    2012-07-01

    Many safeguards measurement systems used at nuclear facilities, both domestically and internationally, rely on He-3 detectors and well established mathematical equations to interpret coincidence and multiplicity-type measurements for verifying quantities of special nuclear material. Due to resource shortages alternatives to these existing He-3 based systems are being sought. Work is also underway to broaden the capabilities of these types of measurement systems in order to improve current multiplicity analysis techniques. As a part of a Material Protection, Accounting, and Control Technology (MPACT) project within the U.S. Department of Energy's Fuel Cycle Technology Program we are designing a fast-neutron multiplicity counter with organic liquid scintillators to quantify important quantities such as plutonium mass. We are also examining the potential benefits of using fast-neutron detectors for multiplicity analysis of advanced fuels in comparison with He-3 detectors and testing the performance of such designs. The designs are being developed and optimized using the MCNPX-PoliMi transport code to study detector response. In the full paper, we will discuss validation measurements used to justify the use of the MCNPX-PoliMi code paired with the MPPost multiplicity routine to design a fast neutron multiplicity counter with liquid scintillators. This multiplicity counter will be designed with the end goal of safeguarding advanced nuclear fuels. With improved timing qualities associated with liquid scintillation detectors, we can design a system that is less limited by nuclear materials of high activities. Initial testing of the designed system with nuclear fuels will take place at Idaho National Laboratory in a later stage of this collaboration.

  16. T-1025 IU SciBath-768 detector tests in MI-12

    SciTech Connect

    Tayloe, Rex; Cooper, R.; Garrison, L.; Thornton, T.; Rebenitsch, L.; DeJongh, Fritz; Loer, Benjamin; Ramberg, Erik; Yoo, Jonghee; /Fermilab

    2012-02-11

    This is a memorandum of understanding between the Fermi National Accelerator Laboratory (Fermilab) and the experimenters of Department of Physics and Center for Exploration of Energy and Matter, Indiana University, who have committed to participate in detector tests to be carried out during the 2012 Fermilab Neutrino program. The memorandum is intended solely for the purpose of recording expectations for budget estimates and work allocations for Fermilab, the funding agencies and the participating institutions. it reflects an arrangement that currently is satisfactory to the parties; however, it is recognized and anticipated that changing circumstances of the evolving research program will necessitate revisions. The parties agree to modify this memorandum to reflect such required adjustments. Actual contractual obligations will be set forth in separate documents. The experimenters propsoe to test their prototype 'SciBat-768' detector in the MI-12 building for 3 months (February-April) in Spring 2012. The major goal of this effort is to measure or limit the flux of beam-induced neutrons in a far-off-axis (> 45{sup o}) location of the Booster Neutrino Beamline (BNB). This flux is of interest for a proposed coherent neutral-current neutrino-argon elastic scattering experiment. A second goal is to collect more test data for the SciBath-768 to enable better understanding and calibration of the device. The SciBath-768 detector successfully ran for 3 months in the MINOS Underground Area in Fall 2011 as testbeam experiment T-1014 and is currently running above ground in the MINOS service building. For the run proposed here, the experiments are requesting: space in MI-12 in which to run the SciBath detector during February-April 2012 while the BNB is operating; technical support to help with moving the equipment on site; access to power, internet, and accelerator signals; and a small office space from which to run and monitor the experiment.

  17. MiR-520b suppresses proliferation of hepatoma cells through targeting ten-eleven translocation 1 (TET1) mRNA

    SciTech Connect

    Zhang, Weiying; Lu, Zhanping; Gao, Yuen; Ye, Lihong; Song, Tianqiang; Zhang, Xiaodong

    2015-05-08

    Accumulating evidence indicates that microRNAs are able to act as oncogenes or tumor suppressor genes in human cancer. We previously reported that miR-520b was down-regulated in hepatocellular carcinoma (HCC) and its deregulation was involved in hepatocarcinogenesis. In the present study, we report that miR-520b suppresses cell proliferation in HCC through targeting the ten-eleven translocation 1 (TET1) mRNA. Notably, we identified that miR-520b was able to target 3′-untranslated region (3′UTR) of TET1 mRNA by luciferase reporter gene assays. Then, we revealed that miR-520b was able to reduce the expression of TET1 at the levels of mRNA and protein using reverse transcription-polymerase chain reaction and Western blotting analysis. In terms of function, 5-ethynyl-2-deoxyuridine (EdU) incorporation and colony formation assays demonstrated that the forced miR-520b expression remarkably inhibited proliferation of hepatoma cells, but TET1 overexpression could rescue the inhibition of cell proliferation mediated by miR-520b. Furthermore, anti-miR-520b enhanced proliferation of hepatoma cells, whereas silencing of TET1 abolished anti-miR-520b-induced acceleration of cell proliferation. Then, we validated that the expression levels of miR-520b were negatively related to those of TET1 mRNA in clinical HCC tissues. Thus, we conclude that miR-520b depresses proliferation of liver cancer cells through targeting 3′UTR of TET1 mRNA. Our finding provides new insights into the mechanism of hepatocarcinogenesis. - Highlights: • TET1 is a novel target gene of miR-520b. • TET1 is upregulated in clinical HCC tissues. • MiR-520b is negatively correlated with TET1 in clinical HCC tissues. • MiR-520b depresses the proliferation of HCC cells through targeting TET1 mRNA.

  18. HARP targets pion production cross section and yield measurements. Implications for MiniBooNE neutrino flux

    SciTech Connect

    Wickremasinghe, Don Athula Abeyarathna

    2015-07-01

    The prediction of the muon neutrino flux from a 71.0 cm long beryllium target for the MiniBooNE experiment is based on a measured pion production cross section which was taken from a short beryllium target (2.0 cm thick - 5% nuclear interaction length) in the Hadron Production (HARP) experiment at CERN. To verify the extrapolation to our longer target, HARP also measured the pion production from 20.0 cm and 40.0 cm beryllium targets. The measured production yields, d2Nπ± (p; θ )=dpd Ω, on targets of 50% and 100% nuclear interaction lengths in the kinematic rage of momentum from 0.75 GeV/c to 6.5 GeV/c and the range of angle from 30 mrad to 210 mrad are presented along with an update of the short target cross sections. The best fitted extended Sanford-Wang (SW) model parameterization for updated short beryllium target π+ production cross section is presented. Yield measurements for all three targets are also compared with that from the Monte Carlo predictions in the MiniBooNE experiment for different SW parameterization. The comparisons of vμ flux predictions for updated SW model is presented.

  19. Forward fitting of experimental data from a NE213 neutron detector installed with the magnetic proton recoil upgraded spectrometer at JET

    SciTech Connect

    Binda, F. Ericsson, G.; Eriksson, J.; Hellesen, C.; Conroy, S.; Sundn, E. Andersson; Collaboration: JET-EFDA Team

    2014-11-15

    In this paper, we present the results obtained from the data analysis of neutron spectra measured with a NE213 liquid scintillator at JET. We calculated the neutron response matrix of the instrument combining MCNPX simulations, a generic proton light output function measured with another detector and the fit of data from ohmic pulses. For the analysis, we selected a set of pulses with neutral beam injection heating (NBI) only and we applied a forward fitting procedure of modeled spectral components to extract the fraction of thermal neutron emission. The results showed the same trend of the ones obtained with the dedicated spectrometer TOFOR, even though the values from the NE213 analysis were systematically higher. This discrepancy is probably due to the different lines of sight of the two spectrometers (tangential for the NE213, vertical for TOFOR). The uncertainties on the thermal fraction estimates were from 4 to 7 times higher than the ones from the TOFOR analysis.

  20. Publisher's Note: Level structure 18Ne and its importance in the 14O(α,p)17F reaction rate [Phys. Rev. C 86, 025801(2012)

    DOE PAGES [OSTI]

    Almaraz-Calderon, S.; Tan, W. P.; Aprahamian, A.; Bucher, B.; Roberts, A.; Wiescher, M.; Brune, C. R.; Massey, T. N.; Ozkan, N.; Guray, R. T.; et al

    2012-08-10

    The level structure of 18Ne above the α-decay threshold has been studied using the 16O(3He,n) reaction. A coincidence measurement of neutrons and charged particles decaying from populated states in 18Ne has been made. Decay branching ratios were measured for six resonances and used to calculate the 14O(α,p)17F reaction rate which is a measure of one of two breakout paths from the Hot CNO cycle. As a result, the new experimental information combined with previous experimental and theoretical information, provides a more accurate calculation of the reaction rate.

  1. DOE-NE Light Water Reactor Sustainability Program and EPRI Long-Term Operations Program. Joint Research and Development Plan

    SciTech Connect

    Williams, Don

    2014-04-01

    Nuclear power has contributed almost 20% of the total amount of electricity generated in the United States over the past two decades. High capacity factors and low operating costs make nuclear power plants (NPPs) some of the most economical power generators available. Further, nuclear power remains the single largest contributor (nearly 70%) of non-greenhouse gas-emitting electric power generation in the United States. Even when major refurbishments are performed to extend operating life, these plants continue to represent cost-effective, low-carbon assets to the nation’s electrical generation capability. By the end of 2014, about one-third of the existing domestic fleet will have passed their 40th anniversary of power operations, and about one-half of the fleet will reach the same 40-year mark within this decade. Recognizing the challenges associated with pursuing extended service life of commercial nuclear power plants, the U.S. Department of Energy’s (DOE) Office of Nuclear Energy (NE) and the Electric Power Research Institute (EPRI) have established separate but complementary research and development programs (DOE-NE’s Light Water Reactor Sustainability [LWRS] Program and EPRI’s Long-Term Operations [LTO] Program) to address these challenges. To ensure that a proper linkage is maintained between the programs, DOE-NE and EPRI executed a memorandum of understanding in late 2010 to “establish guiding principles under which research activities (between LWRS and LTO) could be coordinated to the benefit of both parties.” This document represents the third annual revision to the initial version (March 2011) of the plan as called for in the memorandum of understanding.

  2. Using the X-FEL to photo-pump X-ray laser transitions in He-like Ne

    SciTech Connect

    Nilsen, J; Rohringer, N

    2011-08-30

    Nearly four decades ago H-like and He-like resonantly photo-pumped laser schemes were proposed for producing X-ray lasers. However, demonstrating these schemes in the laboratory has proved to be elusive because of the difficulty of finding a strong resonant pump line. With the advent of the X-ray free electron laser (X-FEL) at the SLAC Linac Coherent Light Source (LCLS) we now have a tunable X-ray laser source that can be used to replace the pump line in previously proposed laser schemes and allow researchers to study the physics and feasibility of resonantly photo-pumped laser schemes. In this paper we use the X-FEL at 1174 eV to photo-pump the singly excited 1s2p state of He-like Ne to the doubly excited 2p3p state and model gain on the 2p3p-2p2s transition at 175 eV and the 2p3p-1s3p transition at 1017 eV. One motivation for studying this scheme is to explore possible quenching of the gain due to strong non-linear coupling effects from the intense X-FEL beam We compare this scheme with photo-pumping the He-like Ne ground state to the 1s3p singly excited state followed by lasing on the 3p-2s and 3d-2p transitions at 158 and 151 eV. Experiments are being planned at LCLS to study these laser processes and coherent quantum effects.

  3. The RNA-binding protein PCBP2 facilitates gastric carcinoma growth by targeting miR-34a

    SciTech Connect

    Hu, Cheng-En; Liu, Yong-Chao; Zhang, Hui-Dong; Huang, Guang-Jian

    2014-06-13

    Highlights: • PCBP2 is overexpressed in human gastric cancer. • PCBP2 high expression predicts poor survival. • PCBP2 regulates gastric cancer growth in vitro and in vivo. • PCBP2 regulates gastric cancer apoptosis by targeting miR-34a. - Abstract: Gastric carcinoma is the fourth most common cancer worldwide, with a high rate of death and low 5-year survival rate. However, the mechanism underling gastric cancer is still not fully understood. Here in the present study, we identify the RNA-binding protein PCBP2 as an oncogenic protein in human gastric carcinoma. Our results show that PCBP2 is up-regulated in human gastric cancer tissues compared to adjacent normal tissues, and that high level of PCBP2 predicts poor overall and disease-free survival. Knockdown of PCBP2 in gastric cancer cells inhibits cell proliferation and colony formation in vitro, whereas opposing results are obtained when PCBP2 is overexpressed. Our in vivo subcutaneous xenograft results also show that PCBP2 can critically regulate gastric cancer cell growth. In addition, we find that PCBP2-depletion induces apoptosis in gastric cancer cells via up-regulating expression of pro-apoptotic proteins and down-regulating anti-apoptotic proteins. Mechanically, we identify that miR-34a as a target of PCBP2, and that miR-34a is critically essential for the function of PCBP2. In summary, PCBP2 promotes gastric carcinoma development by regulating the level of miR-34a.

  4. Ginsenoside-Rg{sub 1} induces angiogenesis by the inverse regulation of MET tyrosine kinase receptor expression through miR-23a

    SciTech Connect

    Kwok, Hoi-Hin; Chan, Lai-Sheung; Poon, Po-Ying; Yue, Patrick Ying-Kit; Wong, Ricky Ngok-Shun

    2015-09-15

    Therapeutic angiogenesis has been implicated in ischemic diseases and wound healing. Ginsenoside-Rg{sub 1} (Rg{sub 1}), one of the most abundant active components of ginseng, has been demonstrated as an angiogenesis-stimulating compound in different models. There is increasing evidence implicating microRNAs (miRNAs), a group of non-coding RNAs, as important regulators of angiogenesis, but the role of microRNAs in Rg{sub 1}-induced angiogenesis has not been fully explored. In this report, we found that stimulating endothelial cells with Rg{sub 1} could reduce miR-23a expression. In silico experiments predicted hepatocyte growth factor receptor (MET), a well-established mediator of angiogenesis, as the target of miR-23a. Transfection of the miR-23a precursor or inhibitor oligonucleotides validated the inverse relationship of miR-23a and MET expression. Luciferase reporter assays further confirmed the interaction between miR-23a and the MET mRNA 3′-UTR. Intriguingly, ginsenoside-Rg{sub 1} was found to increase MET protein expression in a time-dependent manner. We further demonstrated that ginsenoside-Rg{sub 1}-induced angiogenic activities were indeed mediated through the down-regulation of miR-23a and subsequent up-regulation of MET protein expression, as confirmed by gain- and loss-of-function angiogenic experiments. In summary, our results demonstrated that ginsenoside-Rg{sub 1} could induce angiogenesis by the inverse regulation of MET tyrosine kinase receptor expression through miR-23a. This study has broadened our understanding of the non-genomic effects of ginsenoside-Rg{sub 1,} and provided molecular evidence that warrant further development of natural compound as novel angiogenesis-promoting therapy. - Highlights: • Therapeutic angiogenesis has been implicated in ischemic diseases and wound healing. • Ginsenoside-Rg{sub 1} (Rg{sub 1}) has been demonstrated as an angiogenesis-stimulating compound. • We found that Rg{sub 1} induces angiogenesis by

  5. Analysis of the hydraulic data from the MI fracture zone at the Grimsel Rock Laboratory, Switzerland

    SciTech Connect

    Davey, A.; Karasaki, K.; Long, J.C.S.; Landsfeld, M.; Mensch, A.; Martel, S.J.

    1989-10-01

    One of the major problems in analyzing flow and transport in fractured rock is that the flow may be largely confined to a poorly connected network of fractures. In order to overcome some of this problem, Lawrence Berkeley Laboratory (LBL) has been developing a new type of fracture hydrology model called an equivalent discontinuum model. In this model the authors represent the discontinuous nature of the problem through flow on a partially filled lattice. A key component in constructing an equivalent discontinuum model from this lattice is removing some of the conductive elements such that the system is partially connected in the same manner as the fracture network. This is done through a statistical inverse technique called simulated annealing. The fracture network model is annealed by continually modifying a base model, or template such that the modified systems behave more and more like the observed system. In order to see how the simulated annealing algorithm works, the authors have developed a series of synthetic real cases. In these cases, the real system is completely known so that the results of annealing to steady state data can be evaluated absolutely. The effect of the starting configuration has been studied by varying the percent of conducting elements in the initial configuration. Results have shown that the final configurations converge to about the same percentage of conducting elements. An example using Nagra field data from the Migration Experiment (MI) at Grimsel Rock Laboratory in Switzerland is also analyzed. 24 refs., 33 figs., 3 tabs.

  6. A Flexible Baseline Design for the Advanced High Temperature Reactor Using Metallic Internals (AHTR-MI)

    SciTech Connect

    Peterson, Per F.; Haihua, Zhao

    2006-07-01

    The Advanced High Temperature Reactor (AHTR) is a novel reactor concept that uses clean liquid fluoride salts as a high temperature primary coolant for conventional graphite matrix, coated particle fuels. The very large volumetric heat capacity and excellent natural circulation heat transfer provided by liquid salts enables the design of high-temperature reactors with passive safety features and thermal powers ranging from 2400 to 4000 MW(t). To make optimal use of existing design information, early AHTR designs were modeled upon the S-PRISM sodium pool-reactor design, but introduced an insulated reactor vessel. Subsequent work has shown that liquid-salt cooled systems share important similarities with pressurized water reactors, which use a closed primary loop. This article discusses the use of a closed primary loop immersed in a separate buffer salt tank, which permits the primary loop components to be fabricated from metallic materials (AHTR-MI). This approach may provide several key advantages over open loop approaches, including very large thermal inertia. (authors)

  7. Application of the explicitly correlated coupled-cluster models CCSD(F12*) and CC3(F12*) to the hyperpolarizability of the Ne atom

    SciTech Connect

    Hanauer, Matthias; Khn, Andreas

    2015-01-22

    This work demonstrates the performance of the recently proposed explicitly correlated coupled-cluster method CCSD(F12*) and a new method using explicitly correlated triple excitations, CC3(F12*), in the calculation of the static ESHG hyperpolarizability of the Ne atom.

  8. Monocyte to macrophage differentiation-associated (MMD) targeted by miR-140-5p regulates tumor growth in non-small cell lung cancer

    SciTech Connect

    Li, Weina; He, Fei

    2014-07-18

    Highlights: • Expression of MMD is increased in lung cancer tissues. • Knockdown of MMD inhibits growth of A549 and LLC cells in vitro and in vivo. • MMD is a direct functional target of miR-140-5p. • MiR-140-5p/MMD axis regulates Erk1/2 signaling. - Abstract: Monocyte to macrophage differentiation-associated (MMD) is identified in macrophages as a gene associated with the differentiation from monocytes to macrophages. Recent microarray analysis for non-small cell lung cancer (NSCLC) suggests that MMD is an important signature associated with relapse and survival among patients with NSCLC. Therefore, we speculate that MMD likely plays a role in lung cancer. In this study, we found that the protein level of MMD was increased in lung cancer compared to benign lung tissues, and knockdown of MMD inhibited the growth of A549 and Lewis lung cancer cells (LLC) in vitro and in vivo. Integrated analysis demonstrated that MMD was a direct functional target of miR-140-5p. Furthermore, we found that miR-140-5p/MMD axis could affect the cell proliferation of lung cancer cells by regulating Erk signaling. Together, our results highlight the significance of miR-140-5p/MMD axis in lung cancer, and miR-140-5p/MMD axis could serve as new molecular targets for the therapy against lung cancer.

  9. Executive summary of major NuMI lessons learned: a review of relevant meetings of Fermilab's DUSEL Beamline Working Group

    SciTech Connect

    Andrews, Mike; Appel, Jeffrey A.; Bogert, Dixon; Childress, Sam; Cossairt, Don; Griffing, William; Grossman, Nancy; Harding, David; Hylen, Jim; Kuchler, Vic; Laughton, Chris; /Fermilab /Argonne /Brookhaven /LBL, Berkeley

    2009-05-01

    We have gained tremendous experience with the NuMI Project on what was a new level of neutrino beams from a high power proton source. We expect to build on that experience for any new long baseline neutrino beam. In particular, we have learned about some things which have worked well and/or where the experience is fairly directly applicable to the next project (e.g., similar civil construction issues including: tunneling, service buildings, outfitting, and potential claims/legal issues). Some things might be done very differently (e.g., decay pipe, windows, target, beam dump, and precision of power supply control/monitoring). The NuMI experience does lead to identification of critical items for any future such project, and what issues it will be important to address. The DUSEL Beamline Working Group established at Fermilab has been meeting weekly to collect and discuss information from that NuMI experience. This document attempts to assemble much of that information in one place. In this Executive Summary, we group relevant discussion of some of the major issues and lessons learned under seven categories: (1) Differences Between the NuMI Project and Any Next Project; (2) The Process of Starting Up the Project; (3) Decision and Review Processes; (4) ES&H: Environment, Safety, and Health; (5) Local Community Buy-In; (6) Transition from Project Status to Operation; and (7) Some Lessons on Technical Elements. We concentrate here on internal project management issues, including technical areas that require special attention. We cannot ignore, however, two major external management problems that plagued the NuMI project. The first problem was the top-down imposition of an unrealistic combination of scope, cost, and schedule. This situation was partially corrected by a rebaselining. However, the full, desirable scope was never achievable. The second problem was a crippling shortage of resources. Critical early design work could not be done in a timely fashion, leading to

  10. Hepatitis B virus X protein mutant HBxΔ127 promotes proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT

    SciTech Connect

    Liu, Fabao; You, Xiaona; Chi, Xiumei; Wang, Tao; Ye, Lihong; Niu, Junqi; Zhang, Xiaodong

    2014-02-07

    Highlights: • Relative to wild type HBx, HBX mutant HBxΔ127 strongly enhances cell proliferation. • Relative to wild type HBx, HBxΔ127 remarkably up-regulates miR-215 in hepatoma cells. • HBxΔ127-elevated miR-215 promotes cell proliferation via targeting PTPRT mRNA. - Abstract: The mutant of virus is a frequent event. Hepatitis B virus X protein (HBx) plays a vital role in the development of hepatocellular carcinoma (HCC). Therefore, the identification of potent mutant of HBx in hepatocarcinogenesis is significant. Previously, we identified a natural mutant of the HBx gene (termed HBxΔ127). Relative to wild type HBx, HBxΔ127 strongly enhanced cell proliferation and migration in HCC. In this study, we aim to explore the mechanism of HBxΔ127 in promotion of proliferation of hepatoma cells. Our data showed that both wild type HBx and HBxΔ127 could increase the expression of miR-215 in hepatoma HepG2 and H7402 cells. However, HBxΔ127 was able to significantly increase miR-215 expression relative to wild type HBx in the cells. We identified that protein tyrosine phosphatase, receptor type T (PTPRT) was one of the target genes of miR-215 through targeting 3′UTR of PTPRT mRNA. In function, miR-215 was able to promote the proliferation of hepatoma cells. Meanwhile anti-miR-215 could partially abolish the enhancement of cell proliferation mediated by HBxΔ127 in vitro. Knockdown of PTPRT by siRNA could distinctly suppress the decrease of cell proliferation mediated by anti-miR-215 in HepG2-XΔ127/H7402-XΔ127 cells. Moreover, we found that anti-miR-215 remarkably inhibited the tumor growth of hepatoma cells in nude mice. Collectively, relative to wild type HBx, HBxΔ127 strongly enhances proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT. Our finding provides new insights into the mechanism of HBx mutant HBxΔ127 in promotion of proliferation of hepatoma cells.

  11. A Measurement of the Neutrino Neutral Current π0 Cross Section at MiniBooNE

    SciTech Connect

    Raaf, Jennifer Lynne

    2005-01-01

    The MiniBooNE neutrino beam and detector at Fermilab are used to study the production of neutral current π0 events. The cross sections for neutrino interactions with mineral oil (CH2) are reported for resonantly produced and coherently produced single π0 events. We measure a resonant single π0 cross section of σ(vμ N π0) = (0.0129 ± 0.0011(stat.) ± 0.0043(syst.)) x 10-36 cm2/CH2 at a mean neutrino energy of 1.26 GeV. We measure a coherent single π0 cross section of σ(vμ A → vμ A π0) = (0.00077 ± 0.00016 (stat.) ± 0.00036 (syst.)) x 10-36 cm2/CH2 at mean neutrino energy 1.12 GeV.

  12. Theoretical investigation of HNgNH{sub 3}{sup +} ions (Ng = He, Ne, Ar, Kr, and Xe)

    SciTech Connect

    Gao, Kunqi; Sheng, Li

    2015-04-14

    The equilibrium geometries, harmonic frequencies, and dissociation energies of HNgNH{sub 3}{sup +} ions (Ng = He, Ne, Ar, Kr, and Xe) were investigated using the following method: Becke-3-parameter-Lee-Yang-Parr (B3LYP), Boese-Matrin for Kinetics (BMK), second-order Mller-Plesset perturbation theory (MP2), and coupled-cluster with single and double excitations as well as perturbative inclusion of triples (CCSD(T)). The results indicate that HHeNH{sub 3}{sup +}, HArNH{sub 3}{sup +}, HKrNH{sub 3}{sup +}, and HXeNH{sub 3}{sup +} ions are metastable species that are protected from decomposition by high energy barriers, whereas the HNeNH{sub 3}{sup +} ion is unstable because of its relatively small energy barrier for decomposition. The bonding nature of noble-gas atoms in HNgNH{sub 3}{sup +} was also analyzed using the atoms in molecules approach, natural energy decomposition analysis, and natural bond orbital analysis.

  13. PETROPHYSICAL INVESTIGATION OF THE SECONDARY RECOVERY POTENTIAL IN THE CHERRY CANYON FORMATION NE LEA FIELD LEA COUNTY, NEW MEXICO

    SciTech Connect

    T. Scott Hickman

    2002-06-01

    Read and Stevens has proposed the evaluation of the waterflood potential from the Cherry Canyon formation in the NE Lea Field in lea County, New Mexico. Much of the development in this area is approaching primary recovery limitations; additional recovery of remaining oil reserves by waterflood needs to be evaluated. The Cherry Canyon formation is composed of fine grained sandstone, containing clay material which results in high water saturation, and also has the tendency to swell and reduce reservoir permeability--the ability of fluid to flow through the rock pores and fractures. There are also abundant organic materials that interfere with obtaining reliable well logs. These complications have limited oil in place calculations and identification of net pay zones, presenting a challenge to the planned waterflood. Core analysis of the Cherry Canyon should improve the understanding of existing well logs and possibly indicate secondary recovery measures, such as waterflood, to enhance field recovery. Lacking truly representative core to provide accurate analyses, Read and Stevens will obtain and preserve fresh core. The consulting firm of T. Scott Hickman and Associates will then collaborate on special core analyses and obtain additional well logs for a more detailed analysis of reservoir properties. The log interpretation will be compared to the core analysis results, and the entire collected data set will be used to assess the potential and economic viability of successfully waterflooding the identified oil zones. Successful results from the project will improve accuracy of log interpretation and establish a methodology for evaluating secondary recovery by waterflood.

  14. Mitsubishi iMiEV: An Electric Mini-Car in NREL's Advanced Technology Vehicle Fleet (Fact Sheet)

    SciTech Connect

    Not Available

    2011-10-01

    This fact sheet highlights the Mitsubishi iMiEV, an electric mini-car in the advanced technology vehicle fleet at the National Renewable Energy Laboratory (NREL). In support of the U.S. Department of Energy's fast-charging research efforts, NREL engineers are conducting charge and discharge performance testing on the vehicle. NREL's advanced technology vehicle fleet features promising technologies to increase efficiency and reduce emissions without sacrificing safety or comfort. The fleet serves as a technology showcase, helping visitors learn about innovative vehicles that are available today or are in development. Vehicles in the fleet are representative of current, advanced, prototype, and emerging technologies.

  15. Clouds, Aerosols and Precipitation in the Marine Boundary Layer (CAP-MBL) AMF Deployment Graciosa Island, Azores, NE Atlantic Ocean May 2009-December 2010

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    the Marine Boundary Layer (CAP-MBL) Graciosa Island, Azores, NE Atlantic Ocean May 2009-December 2010 Rob Wood, University of Washington CAP-MBL Proposal Team AMF Deployment Team Thanks to Mark Miller: AMF Site Scientist Kim Nitschke: AMF Site Manager Importance of Low-Clouds for Climate Imperative that we understand the processes controlling the formation, maintenance and dissipation of low clouds in order to improve their representation in climate models. Which clouds matter for climate

  16. Study of the K{sub stop}{sup -}A{yields}{Sigma}{sup {+-}}{pi}{sup {+-}}A' reaction at DA{Phi}NE

    SciTech Connect

    Agnello, M.; Benussi, L.; Bertani, M.; Fabbri, F. L.; Gianotti, P.; Lucherini, V.; Bhang, H. C.; Bonomi, G.; Moia, F.; Zenoni, A.; Botta, E.; Bressani, T.; Bufalino, S.; Busso, L.; Calvo, D.; De Mori, F.; Feliciello, A.; Filippi, A.; Marcello, S.; Wheadon, R.

    2010-12-28

    This work describes an experimental study of the K{sub stop}{sup -}A{yields}{pi}{sup {+-}}{Sigma}{sup {+-}}A' reaction performed with the FINUDA spectrometer at the DA{Phi}NE {phi}-factory. The reaction is studied via the detection of {pi}{sup +}{pi}{sup -}n events on {sup 6,7}Li, {sup 9}Be, {sup 13}C and {sup 16}O.

  17. Collisional excitation of NH(X{sup 3}Σ{sup −}) by Ne: Potential energy surface, scattering calculations, and comparison with experiments

    SciTech Connect

    Bouhafs, Nezha; Lique, François

    2015-11-14

    We present a new three-dimensional potential energy surface (PES) for the NH(X{sup 3}Σ{sup −})–Ne van der Waals system, which explicitly takes into account the NH vibrational motion. Ab initio calculations of the NH–Ne PES were carried out using the open-shell single- and double-excitation coupled cluster approach with non-iterative perturbational treatment of triple excitations [RCCSD(T)]. The augmented correlation-consistent quadruple zeta (aug-cc-pVQZ) basis set was employed. Mid-bond functions were also included in order to improve the accuracy in the van der Waals well. Using this new PES, we have studied the collisional excitation of NH(X{sup 3}Σ{sup −}) by Ne. Close-coupling calculations of the collisional excitation cross sections of the fine-structure levels of NH by Ne are performed for energies up to 3000 cm{sup −1}, which yield, after thermal average, rate coefficients up to 350 K. The propensity rules between fine-structure levels are reported, and it is found that F-conserving cross sections are larger than F-changing cross sections even if the propensity rules are not as strong as for the NH–He system. The calculated rate coefficients are compared with available experimental measurements at room temperature and a fairly good agreement is found between experimental and theoretical data, confirming the good quality of the scattering calculations and also the accuracy of the potential energy surface used in this work.

  18. Measurement of K+ production cross section by 8 GeV protons using high energy neutrino interactions in the SciBooNE detector

    DOE PAGES [OSTI]

    Cheng, G.

    2011-07-28

    The SciBooNE Collaboration reports K+ production cross section and rate measurements using high energy daughter muon neutrino scattering data off the SciBar polystyrene (C8H8) target in the SciBooNE detector. The K+ mesons are produced by 8 GeV protons striking a beryllium target in Fermilab Booster Neutrino Beam line (BNB). Using observed neutrino and antineutrino events in SciBooNE, we measure d2σ/dpdΩ = (5.34 ±0.76) mb/(GeV/c x sr) for p + Be =K+ + X at mean K+ energy of 3.9 GeV and angle (with respect to the proton beam direction) of 3.7 degrees, corresponding to the selected K+ sample. Compared tomore »Monte Carlo predictions using previous higher energy K+ production measurements, this measurement, which uses the NUANCE neutrino interaction generator, is consistent with a normalization factor of 0.85 ± 0.12. This agreement is evidence that the extrapolation of the higher energy K+ measurements to an 8 GeV beam energy using Feynman scaling is valid. This measurement reduces the error on the K+ production cross section from 40% to 14%.« less

  19. Two-chord interferometry using 3.39 {mu}m He-Ne laser on a flux-coil-generated FRC

    SciTech Connect

    Gota, H.; Deng, B. H.; Gupta, D.; Kiyashko, V.; Knapp, K.; Mendoza, R.; Morehouse, M.; Bolte, N.; Roche, T.; Wessel, F.

    2010-10-15

    A two-chord {lambda}{sub IR}{approx}3.39 {mu}m He-Ne laser interferometer system was developed for a flux-coil-generated field-reversed configuration to estimate the electron density and the total temperature of the field-reversed configuration (FRC) plasma. This two-chord heterodyne interferometer system consists of a single {approx}2 mW infrared He-Ne laser, a visible ({lambda}{sub vis}{approx}632.8 nm) He-Ne laser for the alignment, a 40 MHz acousto-optic modulator, photodetectors, and quadrature phase detectors. Initial measurement was performed and the measured average electron densities were 2-10x10{sup 19} m{sup -3} at two different radial positions in the midplane. A time shift in density was observed as the FRC expands radially. The time evolution of the line-averaged density agrees with the density estimated from the in situ internal magnetic probes, based on a rigid-rotor profile model.

  20. Measurement of K+ production cross section by 8 GeV protons using high energy neutrino interactions in the SciBooNE detector

    DOE PAGES [OSTI]

    Cheng, G.

    2011-07-28

    The SciBooNE Collaboration reports K+ production cross section and rate measurements using high energy daughter muon neutrino scattering data off the SciBar polystyrene (C8H8) target in the SciBooNE detector. The K+ mesons are produced by 8 GeV protons striking a beryllium target in Fermilab Booster Neutrino Beam line (BNB). Using observed neutrino and antineutrino events in SciBooNE, we measure d2σ/dpdΩ = (5.34 ±0.76) mb/(GeV/c x sr) for p + Be =K+ + X at mean K+ energy of 3.9 GeV and angle (with respect to the proton beam direction) of 3.7 degrees, corresponding to the selected K+ sample. Compared tomore » Monte Carlo predictions using previous higher energy K+ production measurements, this measurement, which uses the NUANCE neutrino interaction generator, is consistent with a normalization factor of 0.85 ± 0.12. This agreement is evidence that the extrapolation of the higher energy K+ measurements to an 8 GeV beam energy using Feynman scaling is valid. This measurement reduces the error on the K+ production cross section from 40% to 14%.« less

  1. Improved Search for ν̄μ→ν̄e Oscillations in the MiniBooNE Experiment

    DOE PAGES [OSTI]

    Aguilar-Arevalo, A. A.; Brown, B. C.; Bugel, L.; Cheng, G.; Church, E. D.; Conrad, J. M.; Dharmapalan, R.; Djurcic, Z.; Finley, D. A.; Ford, R.; et al

    2013-04-15

    The MiniBooNE experiment at Fermilab reports results from an analysis of ν¯e appearance data from 11.27×10²⁰ protons on target in the antineutrino mode, an increase of approximately a factor of 2 over the previously reported results. An event excess of 78.4±28.5 events (2.8σ) is observed in the energy range 200QEν<1250 MeV. If interpreted in a two-neutrino oscillation model, ν¯μ→ν¯e, the best oscillation fit to the excess has a probability of 66% while the background-only fit has a χ² probability of 0.5% relative to the best fit. The data are consistent with antineutrino oscillations in the 0.01<Δm²<1.0 eV² range and havemore » some overlap with the evidence for antineutrino oscillations from the Liquid Scintillator Neutrino Detector. All of the major backgrounds are constrained by in situ event measurements so nonoscillation explanations would need to invoke new anomalous background processes. The neutrino mode running also shows an excess at low energy of 162.0±47.8 events (3.4σ) but the energy distribution of the excess is marginally compatible with a simple two neutrino oscillation formalism. Expanded models with several sterile neutrinos can reduce the incompatibility by allowing for CP violating effects between neutrino and antineutrino oscillations.« less

  2. Revitalizing mature miocene reservoirs in NE Anzoategui: A sequence stratigraphic perspective in the Quiamare and La Celba oil fields

    SciTech Connect

    Galeazzi, S.; Paredes, S.; Dellape, D.; Moroder, G.

    1996-08-01

    A large proportion of the oil reserves discovered in NE Anzoategui are contained in the 3000-m-thick Lower to Middle Miocene strata of the Oficina Formation. Light oil and gas are contained in multiple sandstone reservoirs. Most producing zones are isolated by shale separators, and feature independent fluid contacts. Individual producing zones are laterally extensive, but locally they show interruptions and considerable internal heterogeneity. Reservoir compartmentalization is due to second or third order accommodation faulting and stratigraphic terminations. Sandstones yielding commercial production range in thicknesses from 10 to 50 ft, and contain intergranular porosities that vary from 6 to 24%. Conjugate-type subvertical fractures locally provide the difference between commercial and non-commercial flow rates in low porosity sandstones. Typically, drive style varies from dissolved gas drive and gas cap expansion to natural water drive where unaltered oil coexists with meteoric water. The Miocene series are widespread deposits represented by two major transgressive-regressive genetic packages. Observation of facies, parasequence stacking and stratal termination patterns suggests the presence of at least ten depositional sequences. Strata patterns, lithologic and paleontologic criteria indicate that sedimentation took place within a low relief (ramp-type) depositional setting, in depositional environments ranging from coastal plain through estuarine and shallow marine. Individual producing zones represent a variety of systems tracts, which include transgressive systems tracts, lowstand prograding complexes, and less commonly incised valley fill and highstand deposits. A sequence stratigraphic analysis of the reservoirs in the mature Quiamare oil field has led to the delineation and development of important additional shallow reserves.

  3. A survey of Existing V&V, UQ and M&S Data and Knowledge Bases in Support of the Nuclear Energy - Knowledge base for Advanced Modeling and Simulation (NE-KAMS)

    SciTech Connect

    Hyung Lee; Rich Johnson, Ph.D.; Kimberlyn C. Moussesau

    2011-12-01

    The Nuclear Energy - Knowledge base for Advanced Modeling and Simulation (NE-KAMS) is being developed at the Idaho National Laboratory in conjunction with Bettis Laboratory, Sandia National Laboratories, Argonne National Laboratory, Oak Ridge National Laboratory, Utah State University and others. The objective of this consortium is to establish a comprehensive knowledge base to provide Verification and Validation (V&V) and Uncertainty Quantification (UQ) and other resources for advanced modeling and simulation (M&S) in nuclear reactor design and analysis. NE-KAMS will become a valuable resource for the nuclear industry, the national laboratories, the U.S. NRC and the public to help ensure the safe operation of existing and future nuclear reactors. A survey and evaluation of the state-of-the-art of existing V&V and M&S databases, including the Department of Energy and commercial databases, has been performed to ensure that the NE-KAMS effort will not be duplicating existing resources and capabilities and to assess the scope of the effort required to develop and implement NE-KAMS. The survey and evaluation have indeed highlighted the unique set of value-added functionality and services that NE-KAMS will provide to its users. Additionally, the survey has helped develop a better understanding of the architecture and functionality of these data and knowledge bases that can be used to leverage the development of NE-KAMS.

  4. MiniBooNE

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    &5; &6;&17; &6; &5;&14;&22;&5;K&2; &1; F&24;&30;&30;&5;&20;&14; &6;&30;&17; &6;&15;&5;&21; &21; &6; &17; &20;&5;&6; &14; &5; &17; &7; &1; &19;&7;&20;&6;&21;&21;&5;+(66(56-&25;&5;()632&27;&2;%3%&25;&2;&&3;.2&2;4P- &1; 2&6;&21; &5;F &5;&8; &6;&22;&6; &6;&15;&5;&14;&29;&6; &5; &24;&30;&30;&5;&17; &5;,%*P ?E&19;&1;B0B&3;.EO ?E&19;&1;B0B&3;.EO ?E&19;&1;B0B&3;.EO &25;% 27&25;&3;&14;&8;+,&7; N...

  5. MiniBooNE:

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Monroe, Columbia University Moriond Electroweak, March 21, 2004 From kaons: &24; data from HARP & BNL E910 on production &24; high energy e() events in detector &24; events in the LMC...

  6. MiniBooNE

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    8 GeV KE protons from Fermilab Booster Accelerator 1.7 beryllium target (HARP results coming soon) horn focusses + sign mesons and K Can reverse...

  7. 20Ne.PDF

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

  8. 20Ne_78.PDF

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

  9. NE Blog Archive

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    class"field-item odd">

    The 7th Workshop on Risk Informed Regulation and Safety Culture was one of a series of workshops designed by the Office of Nuclear Energy in...

  10. UPdate THE NE

    Energy.gov [DOE] (indexed site)

    Infrastructure projects and 1 Integrated Research Project. NEUP R&D awards were spread across 38 different U.S. universities and colleges in 28 states and the District of Columbia. ...

  11. NE Press Releases

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ...

  12. 625 Marion St. NE

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Dear Dr. Kosson: Oregon appreciates the opportunity to provide comments on the draft methodology for the Hanford Site-Wide Risk Review Project. We especially thank you for your...

  13. NE-23 W

    Office of Legacy Management (LM)

    whether it contains residual radioactivity traceable to activities conducted on behalf of the Manhattan Engineer District or the Atomic Energy C o m m ission (predecessors to DOE). ...

  14. 18Ne.PDF

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

  15. 18Ne_78.PDF

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

  16. 19Ne.PDF

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

  17. 19Ne_78.PDF

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

  18. Greater Cincinnati Regional High School Science Bowl | U.S. DOE...

    Office of Science (SC)

    National Science Bowl U.S. Department of Energy SC-27 Forrestal Building 1000 ... KY Grant County, KY Grayson County, KY Green County, KY Greenup County, KY Hancock ...

  19. Evaluation of Multiplexed 16S rRNA Microbial Population Surveys Using Illumina MiSeq Platform (Seventh Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting 2012)

    ScienceCinema

    Tremblay, Julien [DOE JGI

    2013-01-25

    Julien Tremblay from DOE JGI presents "Evaluation of Multiplexed 16S rRNA Microbial Population Surveys Using Illumina MiSeq Platorm" at the 7th Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting held in June, 2012 in Santa Fe, NM.

  20. A library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila

    SciTech Connect

    Nagarkar-Jaiswal, Sonal; Lee, Pei-Tseng; Campbell, Megan E.; Chen, Kuchuan; Anguiano-Zarate, Stephanie; Cantu Gutierrez, Manuel; Busby, Theodore; Lin, Wen-Wen; He, Yuchun; Schulze, Karen L.; Booth, Benjamin W.; Evans-Holm, Martha; Venken, Koen J.T.; Levis, Robert W.; Spradling, Allan C.; Hoskins, Roger A.; Bellen, Hugo J.

    2015-03-31

    Here, we document a collection of ~7434 MiMIC (Minos Mediated Integration Cassette) insertions of which 2854 are inserted in coding introns. They allowed us to create a library of 400 GFP-tagged genes. We show that 72% of internally tagged proteins are functional, and that more than 90% can be imaged in unfixed tissues. Moreover, the tagged mRNAs can be knocked down by RNAi against GFP (iGFPi), and the tagged proteins can be efficiently knocked down by deGradFP technology. The phenotypes associated with RNA and protein knockdown typically correspond to severe loss of function or null mutant phenotypes. Finally, we demonstrate reversible, spatial, and temporal knockdown of tagged proteins in larvae and adult flies. This new strategy and collection of strains allows unprecedented in vivo manipulations in flies for many genes. These strategies will likely extend to vertebrates.

  1. A library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila

    DOE PAGES [OSTI]

    Nagarkar-Jaiswal, Sonal; Lee, Pei-Tseng; Campbell, Megan E.; Chen, Kuchuan; Anguiano-Zarate, Stephanie; Cantu Gutierrez, Manuel; Busby, Theodore; Lin, Wen-Wen; He, Yuchun; Schulze, Karen L.; et al

    2015-03-31

    Here, we document a collection of ~7434 MiMIC (Minos Mediated Integration Cassette) insertions of which 2854 are inserted in coding introns. They allowed us to create a library of 400 GFP-tagged genes. We show that 72% of internally tagged proteins are functional, and that more than 90% can be imaged in unfixed tissues. Moreover, the tagged mRNAs can be knocked down by RNAi against GFP (iGFPi), and the tagged proteins can be efficiently knocked down by deGradFP technology. The phenotypes associated with RNA and protein knockdown typically correspond to severe loss of function or null mutant phenotypes. Finally, we demonstratemore » reversible, spatial, and temporal knockdown of tagged proteins in larvae and adult flies. This new strategy and collection of strains allows unprecedented in vivo manipulations in flies for many genes. These strategies will likely extend to vertebrates.« less

  2. Repression of miR-17-5p with elevated expression of E2F-1 and c-MYC in non-metastatic hepatocellular carcinoma and enhancement of cell growth upon reversing this expression pattern

    SciTech Connect

    El Tayebi, H.M.; Omar, K.; Hegy, S.; El Maghrabi, M.; El Brolosy, M.; Hosny, K.A.; Esmat, G.; Abdelaziz, A.I.

    2013-05-10

    Highlights: The oncogenic miR-17-5p is downregulated in non-metastatic hepatocellular carcinoma patients. E2F-1 and c-MYC transcripts are upregulated in non-metastatic HCC patients. miR-17-5p forced overexpression inhibited E2F-1 and c-MYC expression in HuH-7 cells. miR-17-5p mimicking increased HuH-7 cell growth, proliferation, migration and colony formation. miR-17-5p is responsible for HCC progression among the c-MYC/E2F-1/miR-17-5p triad members. -- Abstract: E2F-1, c-MYC, and miR-17-5p is a triad of two regulatory loops: a negative and a positive loop, where c-MYC induces the expression of E2F-1 that induces the expression of miR-17-5p which in turn reverses the expression of E2F-1 to close the loop. In this study, we investigated this triad for the first time in hepatocellular carcinoma (HCC), where miR-17-5p showed a significant down-regulation in 23 non-metastatic HCC biopsies compared to 10 healthy tissues; however, E2F-1 and c-MYC transcripts were markedly elevated. Forced over-expression of miR-17-5p in HuH-7 cells resulted in enhanced cell proliferation, growth, migration and clonogenicity with concomitant inhibition of E2F-1 and c-MYC transcripts expressions, while antagomirs of miR-17-5p reversed these events. In conclusion, this study revealed a unique pattern of expression for miR-17-5p in non-metastatic HCC patients in contrast to metastatic HCC patients. In addition we show that miR-17-5p is the key player among the triad that tumor growth and spread.

  3. Resonances in Coupled <mimi><mi>Kmi>-<mi>ηK> Scattering from Quantum Chromodynamics

    SciTech Connect

    Dudek, Jozef J.; Edwards, Robert G.; Thomas, Christopher E.; Wilson, David J.

    2014-10-01

    Using first-principles calculation within Quantum Chromodynamics, we are able to reproduce the pattern of experimental strange resonances which appear as complex singularities within coupled πK, ηK scattering amplitudes. We make use of numerical computation within the lattice discretized approach to QCD, extracting the energy dependence of scattering amplitudes through their relation- ship to the discrete spectrum of the theory in a finite-volume, which we map out in unprecedented detail.

  4. Research Needs for Magnetic Fusion Energy Sciences. Report of the Research Needs Workshop (ReNeW) Bethesda, Maryland, June 8-12, 2009

    SciTech Connect

    2009-06-08

    Nuclear fusion - the process that powers the sun - offers an environmentally benign, intrinsically safe energy source with an abundant supply of low-cost fuel. It is the focus of an international research program, including the ITE R fusion collaboration, which involves seven parties representing half the world's population. The realization of fusion power would change the economics and ecology of energy production as profoundly as petroleum exploitation did two centuries ago. The 21st century finds fusion research in a transformed landscape. The worldwide fusion community broadly agrees that the science has advanced to the point where an aggressive action plan, aimed at the remaining barriers to practical fusion energy, is warranted. At the same time, and largely because of its scientific advance, the program faces new challenges; above all it is challenged to demonstrate the timeliness of its promised benefits. In response to this changed landscape, the Office of Fusion Energy Sciences (OFES ) in the US Department of Energy commissioned a number of community-based studies of the key scientific and technical foci of magnetic fusion research. The Research Needs Workshop (ReNeW) for Magnetic Fusion Energy Sciences is a capstone to these studies. In the context of magnetic fusion energy, ReNeW surveyed the issues identified in previous studies, and used them as a starting point to define and characterize the research activities that the advance of fusion as a practical energy source will require. Thus, ReNeW's task was to identify (1) the scientific and technological research frontiers of the fusion program, and, especially, (2) a set of activities that will most effectively advance those frontiers. (Note that ReNeW was not charged with developing a strategic plan or timeline for the implementation of fusion power.) This Report presents a portfolio of research activities for US research in magnetic fusion for the next two decades. It is intended to provide a

  5. A study of muon neutrino disappearance with the MINOS detectors and the NuMI neutrino beam

    SciTech Connect

    Marshall, John Stuart

    2008-06-01

    This thesis presents the results of an analysis of vμ disappearance with the MINOS experiment, which studies the neutrino beam produced by the NuMI facility at Fermi National Accelerator Laboratory. The rates and energy spectra of charged current vμ interactions are measured in two similar detectors, located at distances of 1 km and 735 km along the NuMI beamline. The Near Detector provides accurate measurements of the initial beam composition and energy, while the Far Detector is sensitive to the effects of neutrino oscillations. The analysis uses data collected between May 2005 and March 2007, corresponding to an exposure of 2.5 x 1020 protons on target. As part of the analysis, sophisticated software was developed to identify muon tracks in the detectors and to reconstruct muon kinematics. Events with reconstructed tracks were then analyzed using a multivariate technique to efficiently isolate a pure sample of charged current vμ events. An extrapolation method was also developed, which produces accurate predictions of the Far Detector neutrino energy spectrum, based on data collected at the Near Detector. Finally, several techniques to improve the sensitivity of an oscillation measurement were implemented, and a full study of the systematic uncertainties was performed. Extrapolating from observations at the Near Detector, 733 ± 29 Far Detector events were expected in the absence of oscillations, but only 563 events were observed. This deficit in event rate corresponds to a significance of 4.3 standard deviations. The deficit is energy dependent and clear distortion of the Far Detector energy spectrum is observed. A maximum likelihood analysis, which fully accounts for systematic uncertainties, is used to determine the allowed regions for the oscillation parameters and identifies the best fit values as Δm$2\\atop{32}$ = 2.29$+0.14\\atop{-0.14}$ x 10-3 eV2 and sin223

  6. Microfluidic molecular assay platform for the detection of miRNAs, mRNAs, proteins, and post-translational modifications at single-cell resolution

    SciTech Connect

    Wu, Meiye; Singh, Anup K.

    2014-07-15

    In this study, cell signaling is a dynamic and complex process. A typical signaling pathway may begin with activation of cell surface receptors, leading to activation kinase cascade that culminates in induction of mRNA and non-coding miRNA production in the nucleus, followed by modulation of mRNA expression by miRNAs in the cytosol, and end with production of proteins in response to the signaling pathway. Signaling pathways involve proteins, miRNA, and mRNAs, along with various forms of transient post-translational modifications, and detecting each type of signaling molecule requires categorically different sample preparation methods such as Western blotting for proteins, PCR for nucleic acids, and flow cytometry for post-translational modifications. Since we know that cells in populations behave heterogeneously1, especially in the cases of stem cells, cancer, and hematopoiesis, there is need for a new technology that provides capability to detect and quantify multiple categories of signaling molecules in intact single cells to provide a comprehensive view of the cell’s physiological state. In this technical brief, we describe our microfluidic platform with a portfolio of customized molecular assays that can detect nucleic acids, proteins, and post-translational modifications in single intact cells with >95% reduction in reagent requirement in under 8 hours.

  7. Microfluidic Molecular Assay Platform for the Detection of miRNAs, mRNAs, Proteins, and Posttranslational Modifications at Single-Cell Resolution

    DOE PAGES [OSTI]

    Wu, Meiye; Singh, Anup K.

    2014-07-15

    Cell signaling is a dynamic and complex process. A typical signaling pathway may begin with activation of cell surface receptors, leading to activation kinase cascade that culminates in induction of mRNA and non-coding miRNA production in the nucleus, followed by modulation of mRNA expression by miRNAs in the cytosol, and end with production of proteins in response to the signaling pathway. Signaling pathways involve proteins, miRNA, and mRNAs, along with various forms of transient post-translational modifications, and detecting each type of signaling molecule requires categorically different sample preparation methods such as Western blotting for proteins, PCR for nucleic acids, andmoreflow cytometry for post-translational modifications. Since we know that cells in populations behave heterogeneously1, especially in the cases of stem cells, cancer, and hematopoiesis, there is need for a new technology that provides capability to detect and quantify multiple categories of signaling molecules in intact single cells to provide a comprehensive view of the cells physiological state. In this technical brief, we describe our microfluidic platform with a portfolio of customized molecular assays that can detect nucleic acids, proteins, and post-translational modifications in single intact cells with >95% reduction in reagent requirement in under 8 hours.less

  8. Microfluidic molecular assay platform for the detection of miRNAs, mRNAs, proteins, and post-translational modifications at single-cell resolution

    DOE PAGES [OSTI]

    Wu, Meiye; Singh, Anup K.

    2014-07-15

    In this study, cell signaling is a dynamic and complex process. A typical signaling pathway may begin with activation of cell surface receptors, leading to activation kinase cascade that culminates in induction of mRNA and non-coding miRNA production in the nucleus, followed by modulation of mRNA expression by miRNAs in the cytosol, and end with production of proteins in response to the signaling pathway. Signaling pathways involve proteins, miRNA, and mRNAs, along with various forms of transient post-translational modifications, and detecting each type of signaling molecule requires categorically different sample preparation methods such as Western blotting for proteins, PCR formore » nucleic acids, and flow cytometry for post-translational modifications. Since we know that cells in populations behave heterogeneously1, especially in the cases of stem cells, cancer, and hematopoiesis, there is need for a new technology that provides capability to detect and quantify multiple categories of signaling molecules in intact single cells to provide a comprehensive view of the cell’s physiological state. In this technical brief, we describe our microfluidic platform with a portfolio of customized molecular assays that can detect nucleic acids, proteins, and post-translational modifications in single intact cells with >95% reduction in reagent requirement in under 8 hours.« less

  9. Enhanced T-lymphocyte blastogenic response to tuberculin (PPD) in children of northeast (NE) Thailand supplemented with vitamin A (VA) and zinc (Zn)

    SciTech Connect

    Kramer, T.R.; Udomkesmalee, E.; Dhanamitta, S.; Sirisinha, S.; Charoenkiatkul, S.; Tantipopipat, S.; Banjong, O.; Rojroongwasinkul, N.; Smith, J.C. Jr. Mahidol Univ., Nakhon Pathom )

    1991-03-15

    Beneficial effects of Va and/or Zn supplementation of children in NE Thailand are described in a companion abstract. In the same study, blastogenic response (BR) of T-lymphocytes to concanavalin-A (ConA) and PPD were assayed in cultures containing mononuclear cells (MNC) or whole blood (WB). Methods were previously described. Children were previously vaccinated with BCG. BR to ConA of MNC or WB from children supplemented with VA, Zn, VA + Zn or placebo were similar. BR to PPD of MNC was higher in children receiving VA + Zn than placebo, but not in children supplemented with VA or Zn alone. Data indicate that children with suboptimal VA and Zn nutriture supplemented with < 2 times RDA of these nutrients showed enhanced cellular immunity to PPD. This observation is relevant to BCG immunization program and thus may benefit public health.

  10. Collision-induced Raman scattering by rare-gas atoms: The isotropic spectrum of Ne–Ne and its mean polarizability

    SciTech Connect

    Rachet, Florent; Chrysos, Michael; Dixneuf, Sophie

    2015-05-07

    We report the room-temperature isotropic collision-induced light scattering spectrum of Ne–Ne over a wide interval of Raman shifts, and we compare it with the only available experimental spectrum for that system as well as with spectra calculated quantum-mechanically with the employ of advanced ab initio-computed data for the incremental mean polarizability. The spectral range previously limited to 170 cm{sup −1} is now extended to 485 cm{sup −1} allowing us to successfully solve the inverse-scattering problem toward an analytic model for the mean polarizability that perfectly matches our measurements. We also report the depolarization ratio of the scattering process, lingering over the usefulness of this property for more stringent checks between the various polarizability models.

  11. Idaho National Laboratory Ten-year Site Plan (2012 through 2021) -- DOE-NE's National Nuclear Capability -- Developing and Maintaining the INL Infrastructure

    SciTech Connect

    Cal Ozaki

    2010-06-01

    To meet long-term objectives to transform the Idaho National Laboratory (INL), we are providing an integrated, long-term vision of infrastructure requirements that support research, development and demonstration (RD&D) goals outlined in the DOE strategic plans, including the NE Roadmap and reports such as Facilities for the Future of Nuclear Energy Research: A Twenty-year Outlook. The goal of the INL Ten-year Site Plan (TYSP) is to clearly link RD&D mission goals and INL core capabilities with infrastructure requirements (single and multi-program), establish the 10-year end-state vision for INL complexes, identify and prioritize infrastructure and capability gaps, as well as the most efficient and economic approaches to closing those gaps.

  12. Preliminary Measurement of Neutrino Oscillation Parameters By NuMI/MINOS and Calibration Studies for Improving this Measurement

    SciTech Connect

    Symes, Philip Andrew

    2005-11-01

    This thesis explains the origins of neutrinos and their interactions, and the phenomenon of neutrino oscillations. Experiments for measuring neutrino oscillations are mentioned and the experiment investigated in this thesis, the ''Main Injector Neutrino Oscillation Search'', and its neutrino beam, the Fermi National Accelerator Laboratory's ''Neutrinos At The Main Injector'', are described. MINOS is a long baseline (735 km) neutrino oscillation experiment with a near and a far detector, intended to make precision measurements of the atmospheric sector neutrino oscillation parameters. A measurement is made of the ''atmospheric'' neutrino oscillation parameters, Δm$2\\atop{23}$ and sin2(2θ23), using neutrinos from the NuMI beam. The results of this analysis are compared to measurements at MINOS using neutrinos from the atmosphere and with other experiments. A more detailed method of beam neutrino analysis is discussed, and the extra calibrations needed to perform that analysis properly are described, with special attention paid to two aspects of the calibration, which comprise the bulk of work for this thesis. The light injection calibration system uses LEDs to illuminate the detector readout and provides a normalization of the stability of the detector over time. The hardware and different modi operandi of the system are described. There is a description of installation and commissioning of the system at one of the MINOS detectors. The response normalization of each detector with cosmic ray muons is described. Special attention is paid to the explanation of necessary corrections that must be made to the muon sample in order for the sample to be used to calibrate each detector to the specified accuracy. The performance of the calibration is shown.

  13. Approach to Recover Hydrocarbons from Currently Off-Limit Areas of the Antrim Formation, MI Using Low-Impact Technologies

    SciTech Connect

    James Wood; William Quinlan

    2008-09-30

    The goal of this project was to develop and execute a novel drilling and completion program in the Antrim Shale near the western shoreline of Northern Michigan. The target was the gas in the Lower Antrim Formation (Upper Devonian). Another goal was to see if drilling permits could be obtained from the Michigan DNR that would allow exploitation of reserves currently off-limits to exploration. This project met both of these goals: the DNR (Michigan Department of Natural Resources) issued permits that allow drilling the shallow subsurface for exploration and production. This project obtained drilling permits for the original demonstration well AG-A-MING 4-12 HD (API: 21-009-58153-0000) and AG-A-MING 4-12 HD1 (API: 21-009-58153-0100) as well as for similar Antrim wells in Benzie County, MI, the Colfax 3-28 HD and nearby Colfax 2-28 HD which were substituted for the AG-A-MING well. This project also developed successful techniques and strategies for producing the shallow gas. In addition to the project demonstration well over 20 wells have been drilled to date into the shallow Antrim as a result of this project's findings. Further, fracture stimulation has proven to be a vital step in improving the deliverability of wells to deem them commercial. Our initial plan was very simple; the 'J-well' design. We proposed to drill a vertical or slant well 30.48 meters (100 feet) below the glacial drift, set required casing, then angle back up to tap the resource lying between the base to the drift and the conventional vertical well. The 'J'-well design was tested at Mancelona Township in Antrim County in February of 2007 with the St. Mancelona 2-12 HD 3.

  14. Observation of Electron Neutrino Appearance in the NuMI Beam with the NOvA Experiment

    SciTech Connect

    Niner, Evan David

    2015-01-01

    NOvA is a long-baseline neutrino oscillation experiment that uses two functionally identical detectors separated by 810 kilometers at locations 14 milliradians off-axis from the NuMI muon neutrino beam at Fermilab. At these locations the beam energy peaks at 2 GeV. This baseline is the longest in the world for an accelerator-based neutrino oscillation experiment, which enhances the sensitivity to the neutrino mass ordering. The experiment studies oscillations of the muon neutrino and anti-neutrino beam that is produced. Both detectors completed commissioning in the summer of 2014 and continue to collect data. One of the primary physics goals of the experiment is the measurement of electron neutrino appearance in the muon neutrino beam which yields measurements of the oscillation parameters sin213, δ , and the neutrino mass ordering within the standard model of neutrino oscillations. This thesis presents the analysis of data collected between February 2014 and May 2015, corresponding to 3.52 X 1020 protons-on-target. In this first analysis NOvA recorded 6 electron neutrino candidates, which is a 3.3σ observation of electron neutrino appearance. The T2K experiment performs the same measurement on a baseline of 295 kilometers and has a 1 σ preference for the normal mass ordering over the inverted ordering over the phase space of the CP violating parameter δ, which is also weakly seen in the NOvA result. By the summer of 2016 NOvA will triple its statistics due to increased beam power and a completed detector. If electron neutrinos continue to be observed at the current rate NOvA will be able to establish a mass ordering preference at a similar confidence level to T2K.

  15. Better Buildings Low Income Peer Exchange CallFeaturing: Case...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    NC * Nashua, NH * Oakland, CA * Omaha, NE * Sacramento, CA * San Jose, CA 54... and in aggregate you net 15%? Yes - Omaha (appliances) and MI(utilities) have linked ...

  16. 20Na

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    1969MAZT: 20Na; measured T12, -spectrum; deduced -branching. 20Ne deduced ... E, I, -coin; deduced neutrino spectrum. 2004MI51: 20Na(+), (EC); measured ...

  17. Nuclear Energy -- Knowledge Base for Advanced Modeling and Simulation (NE-KAMS) Code Verification and Validation Data Standards and Requirements: Fluid Dynamics Version 1.0

    SciTech Connect

    Greg Weirs; Hyung Lee

    2011-09-01

    V&V and UQ are the primary means to assess the accuracy and reliability of M&S and, hence, to establish confidence in M&S. Though other industries are establishing standards and requirements for the performance of V&V and UQ, at present, the nuclear industry has not established such standards or requirements. However, the nuclear industry is beginning to recognize that such standards are needed and that the resources needed to support V&V and UQ will be very significant. In fact, no single organization has sufficient resources or expertise required to organize, conduct and maintain a comprehensive V&V and UQ program. What is needed is a systematic and standardized approach to establish and provide V&V and UQ resources at a national or even international level, with a consortium of partners from government, academia and industry. Specifically, what is needed is a structured and cost-effective knowledge base that collects, evaluates and stores verification and validation data, and shows how it can be used to perform V&V and UQ, leveraging collaboration and sharing of resources to support existing engineering and licensing procedures as well as science-based V&V and UQ processes. The Nuclear Energy Knowledge base for Advanced Modeling and Simulation (NE-KAMS) is being developed at the Idaho National Laboratory in conjunction with Bettis Laboratory, Sandia National Laboratories, Argonne National Laboratory, Utah State University and others with the objective of establishing a comprehensive and web-accessible knowledge base to provide V&V and UQ resources for M&S for nuclear reactor design, analysis and licensing. The knowledge base will serve as an important resource for technical exchange and collaboration that will enable credible and reliable computational models and simulations for application to nuclear power. NE-KAMS will serve as a valuable resource for the nuclear industry, academia, the national laboratories, the U.S. Nuclear Regulatory Commission (NRC) and

  18. Arsenite evokes IL-6 secretion, autocrine regulation of STAT3 signaling, and miR-21 expression, processes involved in the EMT and malignant transformation of human bronchial epithelial cells

    SciTech Connect

    Luo, Fei; Xu, Yuan; Ling, Min; Zhao, Yue; Xu, Wenchao; Liang, Xiao; Jiang, Rongrong; Wang, Bairu; Bian, Qian; Liu, Qizhan

    2013-11-15

    Arsenite is an established human carcinogen, and arsenite-induced inflammation contributes to malignant transformation of cells, but the molecular mechanisms by which cancers are produced remain to be established. The present results showed that, evoked by arsenite, secretion of interleukin-6 (IL-6), a pro-inflammatory cytokine, led to the activation of STAT3, a transcription activator, and to increased levels of a microRNA, miR-21. Blocking IL-6 with anti-IL-6 antibody and inhibiting STAT3 activation reduced miR-21 expression. For human bronchial epithelial cells, cultured in the presence of anti-IL-6 antibody for 3 days, the arsenite-induced EMT and malignant transformation were reversed. Thus, IL-6, acting on STAT3 signaling, which up-regulates miR-21in an autocrine manner, contributes to the EMT induced by arsenite. These data define a link from inflammation to EMT in the arsenite-induced malignant transformation of HBE cells. This link, mediated through miRNAs, establishes a mechanism for arsenite-induced lung carcinogenesis. - Highlights: Arsenite evokes IL-6 secretion. IL-6 autocrine mediates STAT3 signaling and up-regulates miR-21expression. Inflammation is involved in arsenite-induced EMT.

  19. Differential cross sections for the reactions <mimi><mi>pmi><mi>pη> and <mimi><mi>pmi><mi>pmi><mi>η>'

    SciTech Connect

    Williams, M.; Krahn, Z.; Applegate, D.; Bellis, M.; Meyer, C. A.; Adhikari, K. P.; Anghinolfi, M.; Baghdasaryan, H.; Ball, J.; Battaglieri, M.; Bedlinskiy, I.; Berman, B. L.; Biselli, A. S.; Bookwalter, C.; Briscoe, W. J.; Brooks, W. K.; Burkert, V. D.; Careccia, S. L.; Carman, D. S.; Cole, P. L.; Collins, P.; Crede, V.; D’Angelo, A.; Daniel, A.; Vita, R. De; Sanctis, E. De; Deur, A.; Dey, B.; Dhamija, S.; Dickson, R.; Djalali, C.; Dodge, G. E.; Doughty, D.; Dugger, M.; Dupre, R.; Alaoui, A. El; Elouadrhiri, L.; Eugenio, P.; Fegan, S.; Fradi, A.; Gabrielyan, M. Y.; Garçon, M.; Gilfoyle, G. P.; Giovanetti, K. L.; Girod, F. X.; Gohn, W.; Golovatch, E.; Gothe, R. W.; Griffioen, K. A.; Guidal, M.; Guler, N.; Guo, L.; Hafidi, K.; Hakobyan, H.; Hanretty, C.; Hassall, N.; Hicks, K.; Holtrop, M.; Ilieva, Y.; Ireland, D. G.; Ishkhanov, B. S.; Isupov, E. L.; Jawalkar, S. S.; Jo, H. S.; Johnstone, J. R.; Joo, K.; Keller, D.; Khandaker, M.; Khetarpal, P.; Kim, W.; Klein, A.; Klein, F. J.; Kubarovsky, V.; Kuleshov, S. V.; Kuznetsov, V.; Livingston, K.; Lu, H. Y.; Mayer, M.; McAndrew, J.; McCracken, M. E.; McKinnon, B.; Mikhailov, K.; Mineeva, T.; Mirazita, M.; Mokeev, V.; Moriya, K.; Morrison, B.; Munevar, E.; Nadel-Turonski, P.; Nepali, C. S.; Niccolai, S.; Niculescu, G.; Niculescu, I.; Niroula, M. R.; Niyazov, R. A.; Osipenko, M.; Ostrovidov, A. I.; Park, K.; Park, S.; Pasyuk, E.; Pereira, S. Anefalos; Perrin, Y.; Pieschacon, D.; Pisano, S.; Pogorelko, O.; Pozdniakov, S.; Price, J. W.; Procureur, S.; Prok, Y.; Protopopescu, D.; Raue, B. A.; Ricco, G.; Ripani, M.; Ritchie, B. G.; Rosner, G.; Rossi, P.; Sabatié, F.; Saini, M. S.; Salamanca, J.; Salgado, C.; Schott, D.; Schumacher, R. A.; Seraydaryan, H.; Sharabian, Y. G.; Smith, E. S.; Sober, D. I.; Sokhan, D.; Stepanyan, S. S.; Stoler, P.; Strakovsky, I. I.; Strauch, S.; Taiuti, M.; Tedeschi, D. J.; Tkachenko, S.; Ungaro, M.; Vineyard, M. F.; Voutier, E.; Watts, D. P.; Weinstein, L. B.; Weygand, D. P.; Wood, M. H.; Zhang, J.; Zhao, B.

    2009-10-29

    In high-statistics differential cross sections for the reactions γ p -> p η and γ p -> p η' the CLAS at Jefferson Lab was used to measure the center-of-mass energies from near threshold up to 2.84 GeV. The eta-prime results are the most precise to date and provide the largest energy and angular coverage. The eta measurements extend the energy range of the world's large-angle results by approximately 300 MeV. These new data, in particular the η' measurements, are likely to help constrain the analyses being performed to search for new baryon resonance states.

  20. Petroleum Marketing Monthly

    Energy Information Administration (EIA) (indexed site)

    Domes c crude oil fi rst purchase prices dollars per barrel Year month U.S. Average PAD District 1 PAD District 2 U.S. Average Less AK North Slope Average NY PA WV Average IL IN KS KY MI NE 1996 18.46 19.41 20.82 20.95 20.99 19.59 20.33 20.86 20.67 20.47 20.24 20.32 19.57 1997 17.23 17.92 19.25 18.49 18.79 17.56 18.60 19.11 18.73 18.63 17.97 18.75 18.10 1998 10.87 11.51 13.21 13.66 13.67 11.95 12.29 12.78 12.49 12.19 11.67 12.39 11.50 1999 15.56 16.38 17.36 18.65 18.49 16.46 17.27 17.37 17.31

  1. Production of cold beams of ND{sub 3} with variable rotational state distributions by electrostatic extraction of He and Ne buffer-gas-cooled beams

    SciTech Connect

    Twyman, Kathryn S.; Bell, Martin T.; Heazlewood, Brianna R.; Softley, Timothy P.

    2014-07-14

    The measurement of the rotational state distribution of a velocity-selected, buffer-gas-cooled beam of ND{sub 3} is described. In an apparatus recently constructed to study cold ion-molecule collisions, the ND{sub 3} beam is extracted from a cryogenically cooled buffer-gas cell using a 2.15 m long electrostatic quadrupole guide with three 90 bends. (2+1) resonance enhanced multiphoton ionization spectra of molecules exiting the guide show that beams of ND{sub 3} can be produced with rotational state populations corresponding to approximately T{sub rot} = 918 K, achieved through manipulation of the temperature of the buffer-gas cell (operated at 6 K or 17 K), the identity of the buffer gas (He or Ne), or the relative densities of the buffer gas and ND{sub 3}. The translational temperature of the guided ND{sub 3} is found to be similar in a 6 K helium and 17 K neon buffer-gas cell (peak kinetic energies of 6.92(0.13) K and 5.90(0.01) K, respectively). The characterization of this cold-molecule source provides an opportunity for the first experimental investigations into the rotational dependence of reaction cross sections in low temperature collisions.

  2. Temperature and pressure shift of the Cs clock transition in the presence of buffer gases: Ne, N{sub 2}, Ar

    SciTech Connect

    Kozlova, Olga; Guerandel, Stephane; Clercq, Emeric de

    2011-06-15

    The ground-state hyperfine resonance line of alkali-metal atoms is frequency shifted in the presence of noble or molecular gases. The buffer gases used in vapor-cell atomic clocks thus induce a temperature-dependent shift of the clock transition frequency. We report on measurements of the pressure and temperature dependence of the Cs clock transition frequency in the presence of Ne, Ar, and N{sub 2} buffer gases. The pressure in the sealed glass vapor cells is measured by means of the shift of the Cs D{sub 1} line. We have also investigated the temperature dependence of the optical shift. From these measurements, we infer the pressure and temperature coefficients of the hyperfine frequency shift. It is then possible to predetermine gas mixture ratios that cancel the temperature sensitivity at a given temperature. This prediction is confirmed experimentally for Ar-N{sub 2} mixtures. These results can be useful for improving the long-term frequency stability of Cs vapor-cell clocks.

  3. Extraordinary luminous soft X-ray transient MAXI J0158744 as an ignition of a nova on a very massive O-Ne white dwarf

    SciTech Connect

    Morii, M.; Serino, M.; Mihara, T.; Sugizaki, M.; Tomida, H.; Kimura, M.; Nakahira, S.; Suwa, F.; Negoro, H.; Kennea, J. A.; Pritchard, T.; Page, K. L.; Osborne, J. P.; Curran, P. A.; Walter, F. M.; Kuin, N. P. M.; Hiroi, K.; Usui, R.; Kawai, N.; Gehrels, N.; and others

    2013-12-20

    We present the observation of an extraordinary luminous soft X-ray transient, MAXI J0158744, by the Monitor of All-sky X-ray Image (MAXI) on 2011 November 11. This transient is characterized by a soft X-ray spectrum, a short duration (1.3 10{sup 3} s < ?T{sub d} < 1.10 10{sup 4} s), a rapid rise (<5.5 10{sup 3} s), and a huge peak luminosity of 2 10{sup 40} erg s{sup 1} in 0.7-7.0 keV band. With Swift observations and optical spectroscopy from the Small and Moderate Aperture Research Telescope System, we confirmed that the transient is a nova explosion, on a white dwarf in a binary with a Be star, located near the Small Magellanic Cloud. An early turn-on of the super-soft X-ray source (SSS) phase (<0.44 days), the short SSS phase duration of about one month, and a 0.92 keV neon emission line found in the third MAXI scan, 1296 s after the first detection, suggest that the explosion involves a small amount of ejecta and is produced on an unusually massive O-Ne white dwarf close to, or possibly over, the Chandrasekhar limit. We propose that the huge luminosity detected with MAXI was due to the fireball phase, a direct manifestation of the ignition of the thermonuclear runaway process in a nova explosion.

  4. Ecloud Build-Up Simulations for the FNAL MI for a Mixed Fill Pattern: Dependence on Peak SEY and Pulse Intensity During the Ramp

    SciTech Connect

    Furman, M. A.

    2010-12-11

    We present simulation results of the build-up of the electron-cloud density n{sub e} in three regions of the FNAL Main Injector (MI) for a beam fill pattern made up of 5 double booster batches followed by a 6th single batch. We vary the pulse intensity in the range N{sub t} = (2-5) x 10{sup 13}, and the beam kinetic energy in the range E{sub k} = 8-120 GeV. We assume a secondary electron emission model qualitatively corresponding to TiN, except that we let the peak value of the secondary electron yield (SEY) {delta}{sub max} vary as a free parameter in a fairly broad range. Our main conclusions are: (1) At fixed N{sub t} there is a clear threshold behavior of n{sub e} as a function of {delta}{sub max} in the range {approx} 1.1-1.3. (2) At fixed {delta}{sub max}, there is a threshold behavior of n{sub e} as a function of N{sub t} provided {delta}{sub max} is sufficiently high; the threshold value of N{sub t} is a function of the characteristics of the region being simulated. (3) The dependence on E{sub k} is weak except possibly at transition energy. Most of these results were informally presented to the relevant MI personnel in April 2010.

  5. F-1 U.S. Energy Information Administration | Annual Energy Outlook...

    Annual Energy Outlook

    Central West North Central East North Central Mountain AK WA MT WY ID NV UT CO AZ NM TX OK IA KS MO IL IN KY TN MS AL FL GA SC NC WV PA NJ MD DE NY CT VT ME RI MA NH VA WI MI OH...

  6. Design and Operation of A Setup with A Camera and Adjustable Mirror to Inspect the Sense-Wire Planes of the Time Projection Chamber Inside the MicroBooNE Cryostat

    SciTech Connect

    Carls, Benjamin; Horton-Smith, Glenn; James, Catherine C.; Kubinski, Robert M.; Pordes, Stephen; Schukraft, Anne; Strauss, Thomas

    2015-08-26

    Detectors in particle physics, particularly when including cryogenic components, are often enclosed in vessels that do not provide any physical or visual access to the detectors themselves after installation. However, it can be desirable for experiments to visually investigate the inside of the vessel. The MicroBooNE cryostat hosts a TPC with sense-wire planes, which had to be inspected for damage such as breakage or sagging. This inspection was performed after the transportation of the vessel with the enclosed detector to its final location, but before filling with liquid argon. Our paper describes an approach to view the inside of the MicroBooNE cryostat with a setup of a camera and a mirror through one of its cryogenic service nozzles. The paper also describes the camera and mirror chosen for the operation, the illumination, and the mechanical structure of the setup. It explains how the system was operated and demonstrates its performance.

  7. The Office of Minority Economic Impact (MI) was established in Fiscal Year 1979 pursuant to Section 641 Title V1, Part 3 of the National Energy Conservation Policy Act (Public Law 95-619), dated November 9, 1978

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Minority Economic Impact (MI) was established in Fiscal Year 1979 pursuant to Section 641 Title V1, Part 3 of the National Energy Conservation Policy Act (Public Law 95- 619), dated November 9, 1978. The following is MI's legislative mandate. PART 3 - - MINORITY ECONOMIC IMPACT SEC. 641. MINORITY ECONOMIC IMPACT. "(a) Establishment of Office of Minority Economic Impact -- Title II of the Department of Energy Organization Act (42 U.S.C. 7131 - - 7139) is amended by adding at the end thereof

  8. Higher temperature reactor materials workshop sponsored by the Department of Energy Office of Nuclear Energy, Science, and Technology (NE) and the Office of Basic Energy Sciences (BES).

    SciTech Connect

    Allen, T.; Bruemmer, S.; Kassner, M.; Odette, R.; Stoller, R.; Was, G.; Wolfer, W.; Zinkle, S.; Elmer, J.; Motta, A.

    2002-08-12

    On March 18-21, 2002, the Department of Energy, Office of Nuclear Energy, Science, and Technology (NE) and the Office of Basic Energy Sciences (BES) sponsored a workshop to identify needs and opportunities for materials research aimed at performance improvements of structural materials in higher temperature reactors. The workshop focused discussion around the reactor concepts proposed as part of the Generation IV Nuclear Energy System Roadmap. The goal of the Generation IV initiative is to make revolutionary improvements in nuclear energy system design in the areas of sustainability, economics, safety and reliability. The Generation IV Nuclear Energy Systems Roadmap working groups have identified operation at higher temperature as an important step in improving economic performance and providing a means for nuclear energy to support thermochemical production of hydrogen. However, the move to higher operating temperatures will require the development and qualification of advanced materials to perform in the more challenging environment. As part of the process of developing advanced materials for these reactor concepts, a fundamental understanding of materials behavior must be established and the data-base defining critical performance limitations of these materials under irradiation must be developed. This workshop reviewed potential reactor designs and operating regimes, potential materials for application in high-temperature reactor environments, anticipated degradation mechanisms, and research necessary to understand and develop reactor materials capable of satisfactory performance while subject to irradiation damage at high temperature. The workshop brought together experts from the reactor materials and fundamental materials science communities to identify research and development needs and opportunities to provide optimum high temperature nuclear energy system structural materials.

  9. US NE MA Site Consumption

    Gasoline and Diesel Fuel Update

    ... Yes Yes No No 0% 20% 40% 60% 80% 100% US MA No Car CAR IS PARKED WITHIN 20 FT OF ELECTRICAL OUTLET More highlights from RECS on housing characteristics and energy-related ...

  10. MiniBooNE Results

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    National Laboratory, Los Alamos, NM 87545, USA E-mail: louis@lanl.gov ABSTRACT The ... However, the low-energy excess is presently unexplained. Additional antineutrino data and ...

  11. BooNE Neutrino Oscillations

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

  12. 17β-Estradiol regulates cell proliferation, colony formation, migration, invasion and promotes apoptosis by upregulating miR-9 and thus degrades MALAT-1 in osteosarcoma cell MG-63 in an estrogen receptor-independent manner

    SciTech Connect

    Fang, Dengfeng; Yang, Hui; Lin, Jing; Teng, Yi; Jiang, Yingying; Chen, Jiao; Li, Yu

    2015-02-20

    In bone, different concentration of estrogen leads to various of physiological processes in osteoblast, such as the proliferation, migration, and apoptosis in an estrogen receptor-dependent manner. But little was known about the estrogen effects on osteosarcoma (OS). In this study, OS cell MG-63 was treated with low (1 nM) or high (100 nM) dose of 17β-Estradiol (E2) with the presence or absence of estrogen receptor α (ERα), for evaluating the E2 effects on proliferation, migration, invasion, colony formation and apoptosis. Consistent with a previous study, high dose of E2 treatment dramatically downregulated expressing level of long non-coding RNA metastasis associated lung adenocarcinoma transcript 1 (MALAT-1). The observation of upregulation of miR-9 after a high dose of E2 treatment indicated the cause of MALAT-1 reduction. Downregulation of MALAT-1 promoted the combination of SFPQ/PTBP2 complex. It was also observed that the proliferation, migration, invasion, colony formation and apoptosis of OS cells were remarkably affected by high dose of E2 treatment, but not by low dose, in an ERα independent manner. Furthermore, the abolishment of the effects on these physiological processes caused by ectopic expression of miR-9 ASOs suggested the necessity of miR-9 in MALAT-1 regulation. Here we found that the high dose of E2 treatment upregulated miR-9 thus posttranscriptionally regulated MALAT-1 RNA level in OS cells, and then the downregulation of MALAT-1 inhibited cell proliferation, migration, invasion and epithelial–mesenchymal transition (EMT) processes in the E2-dose dependent and ER-independent ways. - Highlights: • E2 affects osteosarcoma cell MG-63 in an Estrogen receptor-independent way. • High dose of E2 treatment upregulates miR-9 which target to MALAT-1 RNA. • Upregulated miR-9 degrades MALAT-1 and thus affects combination of SFPQ/PTBP2. • E2 treatment block cell proliferation, colony formation, mobility, and enhance apoptosis.

  13. Research Needs for Fusion-Fission Hybrid Systems. Report of the Research Needs Workshop (ReNeW) Gaithersburg, Maryland, September 30 - October 2, 2009

    SciTech Connect

    2009-09-30

    Largely in anticipation of a possible nuclear renaissance, there has been an enthusiastic renewal of interest in the fusion-fission hybrid concept, driven primarily by some members of the fusion community. A fusion-fission hybrid consists of a neutron-producing fusion core surrounded by a fission blanket. Hybrids are of interest because of their potential to address the main long-term sustainability issues related to nuclear power: fuel supply, energy production, and waste management. As a result of this renewed interest, the U.S. Department of Energy (DOE), with the participation of the Office of Fusion Energy Sciences (OFES), Office of Nuclear Energy (NE), and National Nuclear Security Administration (NNSA), organized a three-day workshop in Gaithersburg, Maryland, from September 30 through October 2, 2009. Participants identified several goals. At the highest level, it was recognized that DOE does not currently support any R&D in the area of fusion-fission hybrids. The question to be addressed was whether or not hybrids offer sufficient promise to motivate DOE to initiate an R&D program in this area. At the next level, the workshop participants were asked to define the research needs and resources required to move the fusion-fission concept forward. The answer to the high-level question was given in two ways. On the one hand, when viewed as a standalone concept, the fusion-fission hybrid does indeed offer the promise of being able to address the sustainability issues associated with conventional nuclear power. On the other hand, when participants were asked whether these hybrid solutions are potentially more attractive than contemplated pure fission solutions (that is, fast burners and fast breeders), there was general consensus that this question could not be quantitatively answered based on the known technical information. Pure fission solutions are based largely on existing both fusion and nuclear technology, thereby prohibiting a fair side-by-side comparison

  14. Extracting the mass dependence and quantum numbers of short-range correlated pairs from <mi>Ami>(<mi>emi>,<mi>emi>'<mi>p>) and <mi>Ami>(<mi>emi>,<mi>emi>'<mi>pp>) scattering

    SciTech Connect

    Colle, C.; Hen, O.; Cosyn, W.; Korover, I.; Piasetzky, E.; Ryckebusch, J.; Weinstein, L. B.

    2015-08-06

    We present an analysis of electroinduced single-proton and two-proton knockout measurements off 12C, 27Al, 56Fe, and 208Pb in kinematics dominated by scattering off SRC pairs.

  15. Design and Operation of A Setup with A Camera and Adjustable Mirror to Inspect the Sense-Wire Planes of the Time Projection Chamber Inside the MicroBooNE Cryostat

    DOE PAGES [OSTI]

    Carls, Benjamin; Horton-Smith, Glenn; James, Catherine C.; Kubinski, Robert M.; Pordes, Stephen; Schukraft, Anne; Strauss, Thomas

    2015-08-26

    Detectors in particle physics, particularly when including cryogenic components, are often enclosed in vessels that do not provide any physical or visual access to the detectors themselves after installation. However, it can be desirable for experiments to visually investigate the inside of the vessel. The MicroBooNE cryostat hosts a TPC with sense-wire planes, which had to be inspected for damage such as breakage or sagging. This inspection was performed after the transportation of the vessel with the enclosed detector to its final location, but before filling with liquid argon. Our paper describes an approach to view the inside of themore » MicroBooNE cryostat with a setup of a camera and a mirror through one of its cryogenic service nozzles. The paper also describes the camera and mirror chosen for the operation, the illumination, and the mechanical structure of the setup. It explains how the system was operated and demonstrates its performance.« less

  16. Improved Measurement of the <mi>?>?<mi mathvariant='normal'>emi>?> Branching Ratio

    SciTech Connect

    Aguilar-Arevalo, A.; Aoki, M.; Blecher, M.; Britton, D. I.; Bryman, D. A.; vom Bruch, D.; Chen, S.; Comfort, J.; Ding, M.; Doria, L.; Cuen-Rochin, S.; Gumplinger, P.; Hussein, A.; Igarashi, Y.; Ito, S.; Kettell, S. H.; Kurchaninov, L.; Littenberg, L. S.; Malbrunot, C.; Mischke, R. E.; Numao, T.; Protopopescu, D.; Sher, A.; Sullivan, T.; Vavilov, D.; Yamada, K.

    2015-08-01

    A new measurement of the branching ratio Re/?=?(?+ ? e+? + ?+ ? e+??)/?(?+ ? ?+? + ?+??+??) resulted in Rexpe/?=[1.23440.0023(stat)0.0019(syst)] x 10-4. This is in agreement with the standard model prediction and improves the test of electron-muon universality to the level of 0.1%.

  17. Photoelectron imaging and theoretical study on the structure and chemical binding of the mixed-ligand M(I) complexes, [HMSH]{sup ?} (M = Cu, Ag, and Au)

    SciTech Connect

    Qin, Zhengbo; Liu, Zhiling; Cong, Ran; Xie, Hua; Tang, Zichao, E-mail: zctang@dicp.ac.cn, E-mail: fanhj@dicp.ac.cn; Fan, Hongjun, E-mail: zctang@dicp.ac.cn, E-mail: fanhj@dicp.ac.cn [State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023 (China)] [State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023 (China)

    2014-03-21

    We have reported a combined photoelectron imaging and theoretical study on gaseous mixed-ligand M(I) complexes of [HMSH]{sup ?} (M = Cu, Ag, and Au). With the aid of Franck-Condon simulations, vibrationally resolved photoelectron spectra yield accurate electron affinities of 3.269(6), 3.669(10), and 3.591(6) eV for [HCuSH], [HAgSH], and [HAuSH], respectively. And low-frequency modes are observed: 368(12) cm{sup ?1} for [HCuSH], 286(12) cm{sup ?1} for [HAgSH], and 327(12) cm{sup ?1} for [HAuSH], respectively. Extensive theoretical calculations are performed to aid in the spectral assignments and the calculated values agree well with the experimental observations. Although the S and H atoms have little discrepancy in electronegativity (2.20 for H and 2.54 for S), distinct bonding properties are demonstrated between HM and MS bond. It is revealed that there exists significant ionic bonding between MS in [HMSH]{sup ?} (M = Cu, Ag, and Au), while a gradual transition from ionic behavior between HCu in [HCuSH]{sup ?} to quite strong covalent bonding between HAu in [HAuSH]{sup ?}, supported by a variety of chemical bonding analyses.

  18. ,"Kentucky Natural Gas Summary"

    Energy Information Administration (EIA) (indexed site)

    Prices" "Sourcekey","N3050KY3","N3010KY3","N3020KY3","N3035KY3","N3045KY3" "Date","Natural Gas Citygate Price in Kentucky (Dollars per Thousand Cubic Feet)","Kentucky Price of ...

  19. File:EIA-Appalach7-TN-KY-LIQ.pdf | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Samuel H. Limerick; Lucy Luo; Gary Long; David F. Morehouse; Jack Perrin; Robert F. King Related Technologies Oil, Natural Gas Creation Date 2005-09-01 Extent Regional...

  20. File:EIA-Appalach7-TN-KY-BOE.pdf | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Samuel H. Limerick; Lucy Luo; Gary Long; David F. Morehouse; Jack Perrin; Robert F. King Related Technologies Oil, Natural Gas Creation Date 2005-09-01 Extent Regional...