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Sample records for gi suk hwang

  1. GI Ventures | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Munich, Bavaria, Germany Zip: 80805 Product: Strategic Equity Partner for mid-sized enterprises and entrepreneurs. References: GI Ventures1 This article is a stub. You can help...

  2. GI Power Corporation Limited GIPCL | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    New Delhi, Delhi (NCT), India Zip: 110020 Sector: Wind energy Product: Delhi-based start-up wind project developer. References: GI Power Corporation Limited (GIPCL)1 This...

  3. OR I GI NA L S I GNE D B Y OR I GI NA L S I GNE D B Y

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    NA L S I GNE D B Y OR I GI NA L S I GNE D B Y

  4. redMaGiC. Selecting Luminous Red Galaxies from the DES Science Verification Data

    SciTech Connect

    Rozo, E.

    2015-07-20

    We introduce redMaGiC, an automated algorithm for selecting Luminous Red Galaxies (LRGs). The algorithm was developed to minimize photometric redshift uncertainties in photometric large-scale structure studies. redMaGiC achieves this by self-training the color-cuts necessary to produce a luminosity-thresholded LRG sam- ple of constant comoving density. Additionally, we demonstrate that redMaGiC photo-zs are very nearly as accurate as the best machine-learning based methods, yet they require minimal spectroscopic training, do not suffer from extrapolation biases, and are very nearly Gaussian. We apply our algorithm to Dark Energy Survey (DES) Science Verification (SV) data to produce a redMaGiC catalog sampling the redshift range z ϵ [0.2,0.8]. Our fiducial sample has a comoving space density of 10-3 (h-1Mpc)-3, and a median photo-z bias (zspec zphoto) and scatter (σz=(1 + z)) of 0.005 and 0.017 respectively.The corresponding 5σ outlier fraction is 1.4%. We also test our algorithm with Sloan Digital Sky Survey (SDSS) Data Release 8 (DR8) and Stripe 82 data, and discuss how spectroscopic training can be used to control photo-z biases at the 0.1% level.

  5. Comparison of GiBUU calculations with MiniBooNE pion production data

    SciTech Connect

    Lalakulich, O.; Mosel, U.

    2015-05-15

    Background: Neutrino-induced pion production can give important informationon the axial coupling to nucleon resonances. Furthermore, pion production represents a major background to quasielastic-like events. one pion production data from the MiniBooNE in charged current neutrino scattering in mineral oil appeared higher than expected within conventional theoretical approaches. Purpose: We aim to investigate which model parameters affect the calculated cross section and how they do this. Method: The Giessen Boltzmann–Uehling–Uhlenbeck (GiBUU) model is used for an investigation of neutrino-nucleus reactions. Results: Presented are integrated and differential cross sections for 1π{sup +} and 1π{sup 0} production before and after final state interactions in comparison with the MiniBooNE data. Conclusions: For the MiniBooNE flux all processes (QE, 1π-background, Δ, higher resonance production, DIS) contribute to the observed final state with one pion of a given charge. The uncertainty in elementary pion production cross sections leads to a corresponding uncertainty in the nuclear cross sections. Final state interactions change the shape of the muon-related observables only slightly, but they significantly change the shape of pion distributions.

  6. Bob Hwang Director, Transportation Energy Center Sandia National...

    Energy.gov [DOE] (indexed site)

    Sandia Sites CRF - Understanding Combustion Processes A Clearly Defined Partnership Mission from the Beginning * Born out of gasoline crises of 1970's - created in 1980 * Built to ...

  7. Dr. J. G. Hwang, President Advanced Technologies and Laboratories...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Focus Group determines a change or interpretation to the HASQAR-D is de minimis (an editorial change or interpretation clarifying but not modifying a requirement - example...

  8. DE-EM-0001971 WIPP M&O G-i PART I - THE SCHEDULE SECTION G CONTRACT ADMINISTRATION DATA

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    G-i PART I - THE SCHEDULE SECTION G CONTRACT ADMINISTRATION DATA Table of Content G.1 TECHNICAL AND ADMINISTRATIVE CORRESPONDENCE/MATTERS .......... 1 G.2 DOE ORGANIZATIONAL PROPERTY MANAGEMENT OFFICER .................... 1 G.3 CONTRACTOR CONTACT ................................................................................. 2 G.4 COST REPORTING PROCEDURES................................................................... 2 DE-EM-0001971 WIPP M&O G-1 PART I - THE SCHEDULE SECTION G

  9. Dr. J. G. Hwang, President Advanced Technologies and Laboratories International, Inc.

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Dr. Imre Gyuk About Us Dr. Imre Gyuk - Energy Storage Program Manager, Office of Electricity Delivery and Energy Reliability Dr. Imre Gyuk Dr. Imre Gyuk is a Energy Storage Program Manager in the Office of Electricity Delivery and Energy Reliability. Most Recent Energy Department Releases Strategic Plan for Energy Storage Safety December 23 Partnering with Vermont for an Innovative Approach to Resilience November 18 Smoothing the Flow of Renewable Solar Energy in California's Central Valley May

  10. Microsoft Word - gorchakov-gi.doc

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... in Figures 5 and 6 for two ranges of periods. The annual cycle and its second and third harmonic make the basic contribution to the long-period variability of the aerosol content. ...

  11. The Small Business Conference Small Businesses Don’t Want to Miss

    Energy.gov [DOE]

    Small business owner Alice Hwang explains the benefits of the Department's Annual Small Business Conference & Expo.

  12. OR I GI N A L S I GN E D B Y OR I GI N A L S I GN E D B Y

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    CONTINATION HEETIREFERENCE NO. OF DOCUMENT BEING CONTINUED AEO COTIUTINS IE DE-AC27-08RV14800/071 2AG OF NAME OF OFFEROR OR CONTRACTOR WASHINGTON RIVER PROTECTION SOLUTIONS LLC ITEM NO. SUPPLIES/SERVICES QUANTITY UNIT UNIT PRICE AMOUNT (A) (B) (C) (D) (E) (F) Account code: De-obligating TDD funds for Fluidized Bed Steam Reforming Treatability Fund 01250 Appr Year 2010 Ailottee 34 Reporting Entity 421301 Object Ciass 25200 Program 1111412 Project 0004263 WFO 0000000 Local Use 0000000 Amount:

  13. OR I GI N A L S I GN E D B Y OR I GI N A L S I GN E D B Y

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

  14. OR I GI N A L S I GN E D B Y OR I GI N A L S I GN...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... during caustic leaching process and never re-precipitates ... the speciation of aluminum in saltcake and sludges ... Section J.4, Attachment 2 Page 78 Tank Operations Contract ...

  15. TO: FILE GiR FROM: SUBJECT: I OWNER(S) Past: Current:

    Office of Legacy Management (LM)

    - '-'-k. FECMED INVOLVE%ENr AT SITE --.---....---....+ Control ---% Health Physics Protec G AECMED managed operations q t Little or None ci AECMED respansible far ...

  16. OR I GI N A L S I GN E D B Y CONTINATION HEETIREFERENCE

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    CONTINATION HEETIREFERENCE NO OF DOCUMENT BEING CONTINUED AEO DE-AC27-08RV14800/064 2AG OF NAME OF OFFEROR OR CONTRACTOR WASHINGTON RIVER PROTECTION SOLUTIONS LLC ITEM NO. SUPPLIES/SERVICES QUANTITY UNIT UNIT PRICE AMOUNT (A) (B) (C) (D) (F)(F Obligated Amount for this Modification: $53, 327, 186.59 New Total Obdigated Amount for this Award: $1, 181,248,170.41 incremental Funded Amount changed: from $1, 127, 920, 983.82 to $1,181,248,170.41 Account code: WRPS Fund 01250 Appr Year 2007 Aiottee 34

  17. In-Situ observation of wet oxidation kinetics on Si (100) via...

    Office of Scientific and Technical Information (OSTI)

    Authors: Hussain, Zahid ; Rossi, Massimiliano ; Mun, Bongjin S. ; Enta, Yoshiharu ; Fadley, Charles S. ; Lee, Ki-Suk ; Kim, Sang-Koog ; Shin, Hyun-Joon ; Hussain, Zahid ; Ross, ...

  18. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Niina H. ; Hong, Kunlun ; Han, Youngkyu ; Smith, Gregory S. ; Do, Changwoo November 2015 , ... Youngkyu ; Ahn, Suk-kyun ; Zhang, Zhe ; Smith, Gregory S. ; Do, Changwoo We demonstrate ...

  19. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    inflammation (1) inorganic, organic, physical, and analytical chemistry (1) iron (1) lungs (1) manganese (1) Filter by Author Dai, Sheng (2) Koros, William J. (2) Lee, Jong Suk ...

  20. OR I GI N A L S I GN E D B Y I REEECNO OF DOCUMENT BEING...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... B-3 - 04 04 04 04 0 04 04 04 0 04 04 04 40 40 4044,4)404 0> COCoCo4 'C Co Co Co 41 Co -0> 0 040> 04 04 -. 0 - 4) o a a 04 04 04 04 04 04 R 040404 0 oi .4, 0) 4. c4 04 04 04 ...

  1. DE-EM-0001971 WIPP M&O G-i PART I - THE SCHEDULE SECTION G CONTRACT...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Office. (c) DOE Contracting Office. The Contracting Officer's address is: Carlsbad Field Office U.S. Department of Energy P.O. Box 3090 Carlsbad, NM 88221 (d) PatentsTechnical ...

  2. OR I GI N A L S I GN E D B Y COTNAINSETIREFERENCE NO. OF DOCUMENT BEING CONTINUED

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    COTNAINSETIREFERENCE NO. OF DOCUMENT BEING CONTINUED ?AGE OF COTNUTONSEE~DE-AC27-08RV14800/063 12 3 NAME OF OFFEROR OR CONTRACTOR WASHINGTON RIVER PROTECTION SOLUTIONS LLC ITEM NO. SUPPLIES/SERVICES QUANTITY UNIT UNIT PRICE AMOUNT (A) (B) (C) (D) (E) (F) $1,126,320, 983.82 to $1,127,920, 983.82 ARRA Fund 06049 Appr Year 2009 Ailottee 34 Reporting Entity 421301 Object Class 25400 Program 1111370 Project 2002110 WFO 0000000 Local Use 0000000 TAS Agency Code 89 TAS Account Code 0253 TAS Subaccount

  3. Direct Imaging of Antiferromagnetic Vortex States

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Recently, a research team from Berkeley, Korea, and China has taken the first direct image ... Young, and A. Scholl (ALS); C. Hwang (Korea Research Institute of Standards and ...

  4. ALSNews Vol. 324

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    group turned to the ALS for a little help. From left to right: Jane Tanamachi, Jeong-Sun Kim, Hye-Mi Park, George Meigs, Suk-Youl Park, Jeong-Hoh Park, Tae-Yang Kim. Jeong-Sun...

  5. ALSNews Vol. 324

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Jeong-Sun Kim, Hye-Mi Park, George Meigs, Suk-Youl Park, Jeong-Hoh Park, Tae-Yang Kim. Jeong-Sun studied at UC Berkeley for most of 2004 as a postdoctoral researcher in Dr....

  6. Structure of Bottlebrush Polymers: Simulations and Neutron Scattering...

    Office of Scientific and Technical Information (OSTI)

    Authors: Zhang, Zhe 1 ; Ahn, Suk-Kyun 1 ; Carrillo, Jan-Michael Y 1 ; Wu, Bin 1 ; Hong, Kunlun 1 ; Smith, Gregory Scott 1 ; Do, Changwoo 1 + Show Author Affiliations ...

  7. Tunable Encapsulation Structure of Block Copolymer Coated Single...

    Office of Scientific and Technical Information (OSTI)

    Authors: Han, Youngkyu 1 ; Ahn, Suk-Kyun 1 ; Zhang, Zhe 2 ; Smith, Gregory Scott 1 ; Do, Changwoo 1 + Show Author Affiliations Oak Ridge National Lab. (ORNL), Oak Ridge, ...

  8. HEI Report 133 Characterization of Metals Emitted from Motor...

    National Nuclear Security Administration (NNSA)

    ... the help of Min-Suk Bae. Dr Robert Smith and students at the University of ... Atmos Environ 37:1163-1173. Aust AE, Ball JC, Hu AA, Lighty JS, Smith KR, Straccia AM, ...

  9. ALSNews Vol. 324

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Dr. Jeong-Sun Kim's group turned to the ALS for a little help. From left to right: Jane Tanamachi, Jeong-Sun Kim, Hye-Mi Park, George Meigs, Suk-Youl Park, Jeong-Hoh Park,...

  10. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Grbel, Gerhard (1) Guo, Hongyu (1) Hernndez, Rebeca (1) Hernndez, Rebeca, E-mail: rhernandez@ictp.csic.es, E-mail: aurora.nogales@csic.es (1) Hwang, Ho-Ling (1) Ishikawa, ...

  11. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    ... Van Allen Probes observation and modeling of chorus excitation and propagation during weak ... The global context of the 14 November 2012 storm event Hwang, K. -J. ; Sibeck, D. G. ; ...

  12. Search for: All records | DOE PAGES

    Office of Scientific and Technical Information (OSTI)

    ... Van Allen Probes observation and modeling of chorus excitation and propagation during weak ... The global context of the 14 November 2012 storm event Hwang, K. -J. ; Sibeck, D. G. ; ...

  13. Search for: All records | DOE PAGES

    Office of Scientific and Technical Information (OSTI)

    American Physical Society Structural Comparison of n-Type and p-Type LaAlO3SrTiO3 Interfaces Yamamoto, Ryosuke ; Bell, Christopher ; Hikita, Yasuyuki ; Hwang, Harold Y. ;...

  14. UNIRIB Publications: 2007 Bibliography

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    J.H. Hamilton, J.K. Hwang, S. Ilyushkin, A. Korgul, W. Krolas, K. Li, R.D. Page, D. Simpson and J.A. Winger, Phys. Rev. Lett. 98, 212501 (2007) ConferencesMeetings Development...

  15. Direct Imaging of Antiferromagnetic Vortex States

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Arenholz, A. Doran, A.T. Young, A. Scholl, C. Hwang, H.W. Zhao, J. Bokor, and Z.Q. Qiu, "Direct observation of imprinted antiferromagnetic vortex states in CoOFeAg(001) discs,"...

  16. Multi-channel polarized thermal emitter (Patent) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    by changing the mutual angle between the orientations of the two gratings. Authors: Lee, Jae-Hwang ; Ho, Kai-Ming ; Constant, Kristen P Publication Date: 2013-07-16 OSTI...

  17. Epitaxial 1D Electron Transport Layers for High-Performance Perovskite

    Office of Scientific and Technical Information (OSTI)

    Solar Cells (Journal Article) | SciTech Connect Epitaxial 1D Electron Transport Layers for High-Performance Perovskite Solar Cells Citation Details In-Document Search Title: Epitaxial 1D Electron Transport Layers for High-Performance Perovskite Solar Cells Authors: Han, Gill Sang ; Chung, Hyun Suk ; Kim, Dong Hoe ; Kim, Byeong Jo ; Lee, Jin-Wook ; Park, Nam-Gyu ; Cho, In Sun ; Lee, Jung-Kun ; Lee, Sangwook ; Jung, Hyun Suk Publication Date: 2015-10-07 OSTI Identifier: 1226161 Report

  18. NT U.S. Department of Energy

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    NT U.S. Department of Energy P.O. Box 450, MSIN 1-6-60 Rich land, Washington 99352 OCT 15 2012 1 2-CPM-0 145 Dr. J. G. Hwang, Project Manager Advanced Technologies and Laboratories International, Inc. P.O. Box 250 Richiand, Washington 99352 Dear Dr. Hwang: CONTRACT NO. DE-AC27-1I0RV 15 051 - TRANSMITTAL OF CONTRACT MODIFICATION 078 The purpose of this letter is to transmit an executed copy of the subj eel modification, which revised Contract Section B, Supplies or Services and PriceslCosts. This

  19. U S. Department-of Energy

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    S. Department-of Energy P.O. Box 450, MSIN 1-6-60 Richland, Washington 99352 SEP 0 6 2012 1 2-CPM-0 122 Dr. J. G. Hwang, Project Manager Advanced Technologies and Laboratories International, Inc. P.O. Box 250 Richland, Washington 99352 Dear Dr. Hwang: CONTRACT NO. DE-AC27-10ORV1 5051 - TRANSMITTAL OF CONTRACT MODIFICATION 076 The purpose of this letter is to transmit an executed copy of the subject modification, which revised Contract Section B, Supplies or Services and Prices/Costs. This

  20. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Jung, Hyun Suk" Name Name ORCID Product Type: All Book/Monograph Conference/Event Journal Article Miscellaneous Patent Program Document Software Manual Technical Report Thesis/Dissertation Subject: Identifier Numbers: Site: All Alaska Power Administration, Juneau, Alaska (United States) Albany Research Center (ARC), Albany, OR (United States) Albuquerque Complex - NNSA Albuquerque Operations Office, Albuquerque, NM (United States) Amarillo National Resource Center for Plutonium, Amarillo,

  1. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Jung, Hyun Suk" Name Name ORCID Product Type: All Book/Monograph Conference/Event Journal Article Miscellaneous Patent Program Document Software Manual Technical Report Thesis/Dissertation Subject: Identifier Numbers: Site: All Alaska Power Administration, Juneau, Alaska (United States) Albany Research Center (ARC), Albany, OR (United States) Albuquerque Complex - NNSA Albuquerque Operations Office, Albuquerque, NM (United States) Amarillo National Resource Center for Plutonium, Amarillo,

  2. Simple Large-Scale Synthesis of Hydroxyapatite Nanoparticles: In Situ

    Office of Scientific and Technical Information (OSTI)

    Observation of Crystallization Process (Journal Article) | SciTech Connect Journal Article: Simple Large-Scale Synthesis of Hydroxyapatite Nanoparticles: In Situ Observation of Crystallization Process Citation Details In-Document Search Title: Simple Large-Scale Synthesis of Hydroxyapatite Nanoparticles: In Situ Observation of Crystallization Process Authors: Kim, Dong Wook ; Cho, In-Sun ; Kim, Jin Young ; Jang, Hae Lin ; Han, Gill Sang ; Ryu, Hyun-Seung ; Shin, Heungsoo ; Jung, Hyun Suk ;

  3. Nanowire-Based Three-Dimensional Transparent Conducting Oxide Electrodes

    Office of Scientific and Technical Information (OSTI)

    for Extremely Fast Charge Collection (Journal Article) | SciTech Connect Nanowire-Based Three-Dimensional Transparent Conducting Oxide Electrodes for Extremely Fast Charge Collection Citation Details In-Document Search Title: Nanowire-Based Three-Dimensional Transparent Conducting Oxide Electrodes for Extremely Fast Charge Collection Authors: Noh, Jun Hong ; Han, Hyun Soo ; Lee, Sangwook ; Kim, Jin Young ; Hong, Kug Sun ; Han, Gil-Sang ; Shin, Hyunjung ; Jung, Hyun Suk Publication Date:

  4. UNIRIB Publications: 2006 Bibliography

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    C.R. Bingham, I.G. Draby, G. Drafta, C. Goodin, C.J. Gross, J.H. Hamilton, A.A. Hecht, J.K. Hwang, D.T. Joss, A. Krogul, W. Krolas, K. Lagergran, K. Li, M.N. Tantawy, J....

  5. SSRL HEADLINES - December 2011

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    6 - December 2011 __________________________________________________________________________ Contents of this Issue: From the Director - Outreach and Support Efforts Science Highlight - Manganese-II Oxidation: A Biotic and Abiotic Process Science Highlight - Characterization of Iron Diazene Complexes in Two Oxidation States Biological SAXS Symposium - A Tribute to Dr. Hiro Tsuruta Awards - Prof. Harold Hwang Named American Physical Society Fellow Announcements - Shipping, Lightsources.org

  6. UNIRIB Publications: 2009 Bibliography

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    C.R. Bingham, C.J. Gross, J.H. Hamilton, J.K. Hwang, S. Ilyushkin, A. Korgul, W. Krolas, ... Thomas, D.J. Vieira, J.B. Wilhelmy, G.L. Wilson, CAARI 2008, AIP Conf.Proc. 1090, 724 ...

  7. Response of High-Tc Superconductor Metamaterials to High Intensity THz

    Office of Scientific and Technical Information (OSTI)

    Radiation (Conference) | SciTech Connect Response of High-Tc Superconductor Metamaterials to High Intensity THz Radiation Citation Details In-Document Search Title: Response of High-Tc Superconductor Metamaterials to High Intensity THz Radiation Authors: Grady, Nathaniel [1] ; Perkins Jr., Bradford G. [2] ; Hwang, Harold Y. [2] ; Brandt, Nate [2] ; Torchinsky, Darius [2] ; Singh, Ranjan [1] ; Yan, Li [3] ; Jia, Quanxi [1] ; Trugman, Stuart A. [1] ; Taylor, Antoinette J. [1] ; Nelson, Keith

  8. Journal Cover Stories

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Journal Cover Stories Journal Cover Stories Here are papers authored by NERSC users that were featured on the cover of the scientific journal in which they were published. You can sort according to any of the headings below. Sort by: Default | Name | Date (low-high) | Date (high-low) | Source | Category Journ Mat Chem A Hwang Enhancement of oxygen reduction reaction activities by Pt nanoclusters decorated on ordered mesoporous porphyrinic carbons April 28, 2016 | Author(s): G. Park et al. |

  9. SASW Measurements at Hanford

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    H - Spectral Analysis of Surface Waves Hanford Site-Wide Probabilistic Seismic Hazard Analysis (PSHA): Seismic Shear Wave Velocity Profiling at Hanford, WA SASW Testing and Analysis Procedures, V s Profiles, Sensitivity Studies and Responses to Technical Integration Team Questions for Pacific Northwest National Laboratory Richland, WA by Kenneth H. Stokoe, II Yin-Cheng Lin Sungmoon Hwang, and Julia Roberts May 7, 2014 Geotechnical Engineering Report GR14-1 Geotechnical Engineering Center Civil

  10. TECHNOLOGY TRANSFER COORDINATORS

    Office of Energy Efficiency and Renewable Energy (EERE)

    Mark Hartney, Director of the Office of Strategic Planning, SLAC, discussed technology transfer at SLAC. Bob Hwang, Director, Transportation Energy Center, Combustion Research Facility, SNL presented on technology transfer at SNL. Elsie Quaite-Randall, Chief Technology Transfer Officer, Innovation and Partnerships Office, LBNL, presented on technology transfer at LBNL. Richard A. Rankin, Director, Industrial Partnerships Office and Economic Development Office (Interim), LLNL, presented on technology transfer at LLNL.

  11. Atmospheric Correction of Satellite Signal in Solar Domain: Impact of Improved Molecular Spectroscopy

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Atmospheric Correction of Satellite Signal in Solar Domain: Impact of Improved Molecular Spectroscopy A. P. Trishchenko Canada Centre for Remote Sensing Ottawa, Ontario, Canada B. Hwang Intermap Technologies Corp. Calgary, Canada Z. Li University of Maryland and The Earth System Science Interdisciplinary Center College Park, Maryland Introduction Atmospheric correction of satellite measurements is a major step in the retrieval of surface reflective properties. It involves removing the effect of

  12. SAND2015-5879

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    5-5879 Unlimited Release Printed July 2015 Development and Evaluation of a Sandia Cooler-based Refrigerator Condenser Program Manager: Thomas E. Felter Authors: Terry A. Johnson, Arthur Kariya, Michael T. Leick, and Mark Zimmerman Energy Innovation Department 8366 Manjie Li, Yilin Du, Hoseong Lee, Yunho Hwang, Reinhard Radermacher Center for Environmental Energy Engineering, Department of Mechanical Engineering University of Maryland Prepared by Sandia National Laboratories Albuquerque, New

  13. ARM - Publications: Science Team Meeting Documents

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Development of a Solar Blind Micropulse Raman Lidar for Boundary Layer Water Vapor Measurements Whiteman, D.N., Mathur, S., Nam, M., Hwang, I.H., and Prasad, C.R., National Aeronautics and Space Administration-Goddard Space Flight Center/Science and Engineering Services, Incorporated Ninth Atmospheric Radiation Measurement (ARM) Science Team Meeting Science and Engineering Services, Inc. of Burtonsville, Maryland, has studied the feasibility of constructing a Micropulse Raman Lidar for measuring

  14. New Hybrid Hole Extraction Layer of Perovskite Solar Cells with a Planar

    Office of Scientific and Technical Information (OSTI)

    p-i-n Geometry (Journal Article) | SciTech Connect New Hybrid Hole Extraction Layer of Perovskite Solar Cells with a Planar p-i-n Geometry Citation Details In-Document Search Title: New Hybrid Hole Extraction Layer of Perovskite Solar Cells with a Planar p-i-n Geometry Authors: Park, Ik Jae ; Park, Min Ah ; Kim, Dong Hoe ; Park, Gyeong Do. ; Kim, Byeong Jo ; Son, Hae Jung ; Ko, Min Jae ; Lee, Doh-Kwon ; Park, Taiho ; Shin, Hyunjung ; Park, Nam-Gyu ; Jung, Hyun Suk ; Kim, Jin Young

  15. Phase-Pure FeSex (x = 1, 2) Nanoparticles with One- and Two-Photon

    Office of Scientific and Technical Information (OSTI)

    Luminescence (Journal Article) | SciTech Connect Journal Article: Phase-Pure FeSex (x = 1, 2) Nanoparticles with One- and Two-Photon Luminescence Citation Details In-Document Search Title: Phase-Pure FeSex (x = 1, 2) Nanoparticles with One- and Two-Photon Luminescence Authors: Mao, Xiang ; Kim, Jin-Gyu ; Han, Jishu ; Jung, Hyun Suk ; Lee, Sang Gil ; Kotov, Nicholas A. ; Lee, Jaebeom Publication Date: 2014-05-21 OSTI Identifier: 1167887 DOE Contract Number: SC0000957 Resource Type: Journal

  16. Photoluminescence and electrical properties of epitaxial Al-doped ZnO

    Office of Scientific and Technical Information (OSTI)

    transparent conducting thin films (Journal Article) | SciTech Connect Photoluminescence and electrical properties of epitaxial Al-doped ZnO transparent conducting thin films Citation Details In-Document Search Title: Photoluminescence and electrical properties of epitaxial Al-doped ZnO transparent conducting thin films Authors: Noh, Jun Hong ; Cho, In-Sun ; Lee, Sangwook ; Cho, Chin Moo ; Han, Hyun Soo ; An, Jae-Sul ; Kwak, Chae Hyun ; Kim, Jin Yong ; Jung, Hyun Suk ; Lee, Jung-Kun ; Hong,

  17. DE-AC27-I1ORVI15051 Modification A009

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    I1ORVI15051 Modification A009 Page 2 of 6 A. The purpose of this modification is to make an equitable adjustment to contract cost relevant to transition cost and the stop work order dated November 27, 2009, and modify the period of performance as detailed below: Reference: 1. ATL Letter dated May 24, 2010, from J.G. Hwang, ATL, to D.A. Gallegos, ORP, "CLIN 1 TRANSITION COST OVERRUN PROPOSAL (Contract Number DE-AC27-1I0RV 1505 1) Background: The contract was awarded on November 20, 2009, and

  18. Transistor operation and mobility enhancement in top-gated LaAlO_3 /

    Office of Scientific and Technical Information (OSTI)

    SrTiO_3 heterostructures (Journal Article) | SciTech Connect Journal Article: Transistor operation and mobility enhancement in top-gated LaAlO_3 / SrTiO_3 heterostructures Citation Details In-Document Search Title: Transistor operation and mobility enhancement in top-gated LaAlO_3 / SrTiO_3 heterostructures Authors: Hosoda, Masayuki ; Hikita, Yasuyuki ; Hwang, Harold Y. ; Bell1, Christopher Publication Date: 2013-06-18 OSTI Identifier: 1084270 Report Number(s): SLAC-PUB-15597 DOE Contract

  19. Compositional and Gate Tuning of the Interfacial Conductivity in

    Office of Scientific and Technical Information (OSTI)

    LaAlO3/LaTiO3/SrTiO3 Heterostructures (Journal Article) | SciTech Connect Compositional and Gate Tuning of the Interfacial Conductivity in LaAlO3/LaTiO3/SrTiO3 Heterostructures Citation Details In-Document Search Title: Compositional and Gate Tuning of the Interfacial Conductivity in LaAlO3/LaTiO3/SrTiO3 Heterostructures Authors: Hosoda, Masayuki ; Bell, Christopher ; Hikita, Yasuyuki ; Hwang, Harold Y. Publication Date: 2012-12-06 OSTI Identifier: 1056813 Report Number(s): SLAC-PUB-15308

  20. Enhancing Electron Mobility at the LaAlO3/SrTiO3 Interface by Surface

    Office of Scientific and Technical Information (OSTI)

    Control (Journal Article) | SciTech Connect Journal Article: Enhancing Electron Mobility at the LaAlO3/SrTiO3 Interface by Surface Control Citation Details In-Document Search Title: Enhancing Electron Mobility at the LaAlO3/SrTiO3 Interface by Surface Control Authors: Xie, Yanwu ; Bell, Christopher ; Hikita, Yasuyuki ; Harashima, Satoshi ; Hwang, Harold Y. Publication Date: 2013-05-29 OSTI Identifier: 1081520 Report Number(s): SLAC-PUB-15494 DOE Contract Number: AC02-76SF00515 Resource Type:

  1. Inelastic x-ray scattering in heterostructures: electronic excitations in

    Office of Scientific and Technical Information (OSTI)

    LaAlO 3 /SrTiO 3 (Journal Article) | SciTech Connect Journal Article: Inelastic x-ray scattering in heterostructures: electronic excitations in LaAlO 3 /SrTiO 3 Citation Details In-Document Search Title: Inelastic x-ray scattering in heterostructures: electronic excitations in LaAlO 3 /SrTiO 3 Authors: Ruotsalainen, Kari O. ; Sahle, Christoph J. ; Ritschel, Tobias ; Geck, Jochen ; Hosoda, Masayuki ; Bell, Christopher ; Hikita, Yasuyuki ; Hwang, Harold Y. ; Fister, Tim T. ; Gordon, Robert A.

  2. Inelastic x-ray scattering in heterostructures: electronic excitations in

    Office of Scientific and Technical Information (OSTI)

    LaAlO 3 /SrTiO 3 (Journal Article) | SciTech Connect Inelastic x-ray scattering in heterostructures: electronic excitations in LaAlO 3 /SrTiO 3 Citation Details In-Document Search Title: Inelastic x-ray scattering in heterostructures: electronic excitations in LaAlO 3 /SrTiO 3 Authors: Ruotsalainen, Kari O. ; Sahle, Christoph J. ; Ritschel, Tobias ; Geck, Jochen ; Hosoda, Masayuki ; Bell, Christopher ; Hikita, Yasuyuki ; Hwang, Harold Y. ; Fister, Tim T. ; Gordon, Robert A. ; Hämäläinen,

  3. Microsoft Word - macro industrial AEO2013 working group 08-02...

    Gasoline and Diesel Fuel Update

    GI's (Global Insights') long-term forecast of GDP. There was no ... of a dynamic price driver (comprised of the ... incentivize boiler fuel switching to natural gas ...

  4. DOE Announces Webinars on Hiring Veterans for Solar Energy Jobs...

    Energy.gov [DOE] (indexed site)

    vets, how the post-911 GI Bill can aid in the hiring ... Practices, National Residential Efficiency Measures ... and Anticipated Fuel Cell Electric Vehicles, Net Metering ...

  5. Dose-Volume Histogram Predictors of Chronic Gastrointestinal Complications After Radical Hysterectomy and Postoperative Concurrent Nedaplatin-Based Chemoradiation Therapy for Early-Stage Cervical Cancer

    SciTech Connect

    Isohashi, Fumiaki; Yoshioka, Yasuo; Mabuchi, Seiji; Konishi, Koji; Koizumi, Masahiko; Takahashi, Yutaka; Ogata, Toshiyuki; Maruoka, Shintaroh; Kimura, Tadashi; Ogawa, Kazuhiko

    2013-03-01

    Purpose: The purpose of this study was to evaluate dose-volume histogram (DVH) predictors for the development of chronic gastrointestinal (GI) complications in cervical cancer patients who underwent radical hysterectomy and postoperative concurrent nedaplatin-based chemoradiation therapy. Methods and Materials: This study analyzed 97 patients who underwent postoperative concurrent chemoradiation therapy. The organs at risk that were contoured were the small bowel loops, large bowel loop, and peritoneal cavity. DVH parameters subjected to analysis included the volumes of these organs receiving more than 15, 30, 40, and 45 Gy (V15-V45) and their mean dose. Associations between DVH parameters or clinical factors and the incidence of grade 2 or higher chronic GI complications were evaluated. Results: Of the clinical factors, smoking and low body mass index (BMI) (<22) were significantly associated with grade 2 or higher chronic GI complications. Also, patients with chronic GI complications had significantly greater V15-V45 volumes and higher mean dose of the small bowel loops compared with those without GI complications. In contrast, no parameters for the large bowel loop or peritoneal cavity were significantly associated with GI complications. Results of the receiver operating characteristics (ROC) curve analysis led to the conclusion that V15-V45 of the small bowel loops has high accuracy for prediction of GI complications. Among these parameters, V40 gave the highest area under the ROC curve. Finally, multivariate analysis was performed with V40 of the small bowel loops and 2 other clinical parameters that were judged to be potential risk factors for chronic GI complications: BMI and smoking. Of these 3 parameters, V40 of the small bowel loops and smoking emerged as independent predictors of chronic GI complications. Conclusions: DVH parameters of the small bowel loops may serve as predictors of grade 2 or higher chronic GI complications after postoperative

  6. Volatilization of selected organic compounds from a creosote-waste land-treatment facility. Master's thesis

    SciTech Connect

    Scott, E.J.

    1989-01-01

    The purpose of this research was to evaluate the emissions of volatile and semi-volatile compounds which are constituents of a complex creosote waste from laboratory simulations of a land treatment system to assess the potential human exposure to hazardous compounds from this source. In addition, the Thibodeaux-Hwang Air Emission Release Rate (AERR) model was evaluated for its use in predicting emission rates of hazardous constituents of creosote wood preservative waste from land treatment facilities. A group of hazardous volatile and semi-volatile constituents present in the creosote waste was selected for evaluation in this study and included a variety of polynuclear aromatic hydrocarbons (PNA's), phenol, and chlorinated and substituted phenols.

  7. --No Title--

    Energy Information Administration (EIA) (indexed site)

    by Source, 2008 (Dollars per Million Btu) State Primary Energy Electric Power Sector g,h Retail Electricity Total Energy g,i Coal Natural Gas a Petroleum Nuclear Fuel Biomass...

  8. A=17B (1993TI07)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    and its ground state probably has J 32- (1974BO05, 1986AJ04) in agreement with the shell model (1992WA22). It has been observed in several heavy ion reactions (1987GI05,...

  9. X:\\ARM_19~1\\P193-223.WPD

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... GI < ,I> (z)U( ) 0.3 0.03 Session Papers 207 (2) (3) last four months of 1994 for the Dobson spectrophotometer The efficiency and accuracy of our ...

  10. AEO2014: Preliminary Industrial Output

    Annual Energy Outlook

    Insights' (GI) May Long-term Trend forecast and this year's ... demand is driven by the price level, income, wealth, ... NG 322 Pulp & paper Fuel Index 32511a9 Bulk ...

  11. MEMORANDUM

    Office of Legacy Management (LM)

    ... Out of the tests at 550C came the knowledge that the metal tended to giVe off hydrogen. This has been explored furt:?er at Buttelle and we, knok j&t wherein this outgassing may ...

  12. Final Technical Report: Integrated Distribution-Transmission...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... a tool was created in Python, and multiple feeders provided by two western U.S. utilities (under NDA with NREL) in SynerGi and CYMDIST format were converted to GridLAB-D format. ...

  13. A=7H (1974AJ01)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    4AJ01) (Not illustrated) A search for 7H in 7Li(π-, π+)7H was unsuccessful (1965GI10). See also (1968CE1A

  14. A=7H (1979AJ01)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    9AJ01) (Not illustrated) A search for 7H in 7Li(π-, π+)7H was unsuccessful (1965GI10). See also (1975BE31, 1977SP1B; theor.

  15. Document (5842k)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... R o o o o o f(R) ' Z RI R-- ...A xeGi- I&127;,zZ r " 3T* ... ? KZy:fu-&127;fz- 6 g...7 -B8 5+p 8R GSj ...

  16. Energy Review

    Annual Energy Outlook

    M iggl-003504t11l)sar Energy Review 8 M. IM W I -W All* r ;ai*i el I gi In this issue: Energy-related housing characteristics Propane-provider fleet survey Ordering...

  17. Cours-IX/Clavin2015.key

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    (Nonlinear stochastic equation) 4 P.Clavin IX IX-2) Turbulent diffusion Einstein 1905 G.I Taylor 1922 Taylor's di usion coecient x 2 (t) 2 t 0 dt t 0 d v(t )v(t ) integration...

  18. Enhancement of [alpha]-Helix Mimicry by an [alpha/beta]-Peptide...

    Office of Scientific and Technical Information (OSTI)

    Authors: Johnson, Lisa M. ; Mortenson, David E. ; Yun, Hyun Gi ; Horne, W. Seth ; Ketas, Thomas J. ; Lu, Min ; Moore, John P. ; Gellman, Samuel H. 1 ; UMD-NJ) 2 ; Weill-Med) ...

  19. PART I - THE SCHEDULE

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    G Contract No. DE-AC06-09RL14728 G-i PART I - THE SCHEDULE SECTION G CONTRACT ADMINISTRATION DATA TABLE OF CONTENTS G.1 CONTRACT ADMINISTRATION ......

  20. Microsoft Word - Section G _Rev 01-23-2006_.doc

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    G Contract No. DE-AC06-05RL14655 M014 G-i PART I - THE SCHEDULE SECTION G CONTRACT ADMINISTRATION DATA TABLE OF CONTENTS G.1 CORRESPONDENCE PROCEDURES......

  1. PART I - THE SCHEDULE

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    G Contract No. DE-AC27-08RV14800 Modification No. 020 G-i PART I - THE SCHEDULE SECTION G CONTRACT ADMINISTRATION DATA TABLE OF CONTENTS G.1 CONTRACT ADMINISTRATION...

  2. PART I - THE SCHEDULE

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    G Contract No. DE-AC06-08RL14788 G-i PART I - THE SCHEDULE SECTION G CONTRACT ADMINISTRATION DATA TABLE OF CONTENTS G.1 CONTRACT ADMINISTRATION ......

  3. Normal Tissue Complication Probability Analysis of Acute Gastrointestinal Toxicity in Cervical Cancer Patients Undergoing Intensity Modulated Radiation Therapy and Concurrent Cisplatin

    SciTech Connect

    Simpson, Daniel R.; Song, William Y.; Moiseenko, Vitali; Rose, Brent S.; Yashar, Catheryn M.; Mundt, Arno J.; Mell, Loren K.

    2012-05-01

    Purpose: To test the hypothesis that increased bowel radiation dose is associated with acute gastrointestinal (GI) toxicity in cervical cancer patients undergoing concurrent chemotherapy and intensity-modulated radiation therapy (IMRT), using a previously derived normal tissue complication probability (NTCP) model. Methods: Fifty patients with Stage I-III cervical cancer undergoing IMRT and concurrent weekly cisplatin were analyzed. Acute GI toxicity was graded using the Radiation Therapy Oncology Group scale, excluding upper GI events. A logistic model was used to test correlations between acute GI toxicity and bowel dosimetric parameters. The primary objective was to test the association between Grade {>=}2 GI toxicity and the volume of bowel receiving {>=}45 Gy (V{sub 45}) using the logistic model. Results: Twenty-three patients (46%) had Grade {>=}2 GI toxicity. The mean (SD) V{sub 45} was 143 mL (99). The mean V{sub 45} values for patients with and without Grade {>=}2 GI toxicity were 176 vs. 115 mL, respectively. Twenty patients (40%) had V{sub 45} >150 mL. The proportion of patients with Grade {>=}2 GI toxicity with and without V{sub 45} >150 mL was 65% vs. 33% (p = 0.03). Logistic model parameter estimates V50 and {gamma} were 161 mL (95% confidence interval [CI] 60-399) and 0.31 (95% CI 0.04-0.63), respectively. On multivariable logistic regression, increased V{sub 45} was associated with an increased odds of Grade {>=}2 GI toxicity (odds ratio 2.19 per 100 mL, 95% CI 1.04-4.63, p = 0.04). Conclusions: Our results support the hypothesis that increasing bowel V{sub 45} is correlated with increased GI toxicity in cervical cancer patients undergoing IMRT and concurrent cisplatin. Reducing bowel V{sub 45} could reduce the risk of Grade {>=}2 GI toxicity by approximately 50% per 100 mL of bowel spared.

  4. Macro-Industrial Working Group: meeting 1

    Energy Information Administration (EIA) (indexed site)

    30 2013 Macroeconomic team: Kay Smith, Russ Tarver, Elizabeth Sendich and Vipin Arora Briefing on Macroeconomic Reference Case for the Annual Energy Outlook 2014 Macroeconomic/Industrial Working Group Meeting Presentation Goals * The Reference Case presented is the GI May Long-term Trend forecast. Due to the comprehensive revision of the GDP accounts, released at the end of July, we will not update the macro projection to an August baseline in order to keep on the AEO2014 schedule. The GI August

  5. Interpolating the Coulomb phase of little string theory

    SciTech Connect

    Lin, Ying -Hsuan; Shao, Shu -Heng; Wang, Yifan; Yin, Xi

    2015-12-03

    We study up to 8-derivative terms in the Coulomb branch effective action of (1,1) little string theory, by collecting results of 4-gluon scattering amplitudes from both perturbative 6D super-Yang-Mills theory up to 4-loop order, and tree-level double scaled little string theory (DSLST). In previous work we have matched the 6-derivative term from the 6D gauge theory to DSLST, indicating that this term is protected on the entire Coulomb branch. The 8-derivative term, on the other hand, is unprotected. In this paper we compute the 8-derivative term by interpolating from the two limits, near the origin and near the infinity on the Coulomb branch, numerically from SU(k) SYM and DSLST respectively, for k=2,3,4,5. We discuss the implication of this result on the UV completion of 6D SYM as well as the strong coupling completion of DSLST. As a result, we also comment on analogous interpolating functions in the Coulomb phase of circle-compactified (2,0) little string theory.

  6. Interpolating the Coulomb phase of little string theory

    DOE PAGES [OSTI]

    Lin, Ying -Hsuan; Shao, Shu -Heng; Wang, Yifan; Yin, Xi

    2015-12-03

    We study up to 8-derivative terms in the Coulomb branch effective action of (1,1) little string theory, by collecting results of 4-gluon scattering amplitudes from both perturbative 6D super-Yang-Mills theory up to 4-loop order, and tree-level double scaled little string theory (DSLST). In previous work we have matched the 6-derivative term from the 6D gauge theory to DSLST, indicating that this term is protected on the entire Coulomb branch. The 8-derivative term, on the other hand, is unprotected. In this paper we compute the 8-derivative term by interpolating from the two limits, near the origin and near the infinity onmore » the Coulomb branch, numerically from SU(k) SYM and DSLST respectively, for k=2,3,4,5. We discuss the implication of this result on the UV completion of 6D SYM as well as the strong coupling completion of DSLST. As a result, we also comment on analogous interpolating functions in the Coulomb phase of circle-compactified (2,0) little string theory.« less

  7. A=12C (1968AJ02)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    68AJ02) (See Energy Level Diagrams for 12C) GENERAL: See also Table 12.7 [Table of Energy Levels] (in PDF or PS). Shell model: (1956KU1A, 1956PE1A, 1957KU58, 1960ME1C, 1960TA1C, 1960WE1C, 1961BA1E, 1961TR1B, 1963NA04, 1963VI1A, 1964AM1D, 1964CL1A, 1964GI1B, 1964GI1C, 1964NE1E, 1965BA2E, 1965CO25, 1965FA1C, 1965NE1C, 1966GI1A, 1966HA18, 1966VA1D, 1966YO1B, 1967CO32, 1967EV1C, 1967KU1N, 1968HI1H). Collective model: (1959BA1F, 1959BR1E, 1961CL10, 1962CL13, 1962GO1R, 1962WA17, 1963GO1Q, 1964BR1H,

  8. Regulation of chloroplast biogenesis: the immutans mutant of Arabidopsis

    SciTech Connect

    Rodermel, Steven

    2015-11-16

    The immutans (im) variegation mutant of Arabidopsis is an ideal model to gain insight into factors that control chloroplast biogenesis. im defines the gene for PTOX, a plastoquinol terminal oxidase that participates in control of thylakoid redox. Here, we report that the im defect can be suppressed during the late stages of plant development by gigantea (gi2), which defines the gene for GIGANTEA (GI), a central component of the circadian clock that plays a poorly-understood role in diverse plant developmental processes. imgi2 mutants are late-flowering and display other well-known phenotypes associated with gi2, such as starch accumulation and resistance to oxidative stress. We show that the restoration of chloroplast biogenesis in imgi2 is caused by a developmental-specific de-repression of cytokinin signaling that involves crosstalk with signaling pathways mediated by gibberellin (GA) and SPINDLY (SPY), a GA response inhibitor. Suppression of the plastid defect in imgi2 is likely caused by a relaxation of excitation pressures in developing plastids by factors contributed by gi2, including enhanced rates of photosynthesis and increased resistance to oxidative stress. Interestingly, the suppression phenotype of imgi can be mimicked by crossing im with the starch accumulation mutant, sex1, perhaps because sex1 utilizes pathways similar to gi. We conclude that our studies provide a direct genetic linkage between GIGANTEA and chloroplast biogenesis, and we construct a model of interactions between signaling pathways mediated by gi, GA, SPY, cytokinins, and sex1 that are required for chloroplast biogenesis.

  9. Role of Principal Component Analysis in Predicting Toxicity in Prostate Cancer Patients Treated With Hypofractionated Intensity-Modulated Radiation Therapy

    SciTech Connect

    Vesprini, Danny; Sia, Michael; Lockwood, Gina; Moseley, Douglas; Rosewall, Tara; Bayley, Andrew; Bristow, Robert; Chung, Peter; Menard, Cynthia; Milosevic, Michael; Warde, Padraig; Catton, Charles

    2011-11-15

    Purpose: To determine if principal component analysis (PCA) and standard parameters of rectal and bladder wall dose-volume histograms (DVHs) of prostate cancer patients treated with hypofractionated image-guided intensity-modulated radiotherapy (hypo-IMRT) can predict acute and late gastrointestinal (GI) toxicity. Methods and Materials: One hundred twenty-one patients underwent hypo-IMRT at 3 Gy/fraction, 5 days/week to either 60 Gy or 66 Gy, with daily online image guidance. Acute and late GI and genitourinary (GU) toxicity were recorded weekly during treatment and at each follow-up. All Radiation Therapy Oncology Group (RTOG) criteria toxicity scores were dichotomized as <2 and {>=}2. Standard dosimetric parameters and the first five to six principal components (PCs) of bladder and rectal wall DVHs were tested for association with the dichotomized toxicity outcomes, using logistic regression. Results: Median follow-up of all patients was 47 months (60 Gy cohort= 52 months; 66 Gy cohort= 31 months). The incidence rates of {>=}2 acute GI and GU toxicity were 14% and 29%, respectively, with no Grade {>=}3 acute GU toxicity. Late GI and GU toxicity scores {>=}2 were 16% and 15%, respectively. There was a significant difference in late GI toxicity {>=}2 when comparing the 66 Gy to the 60 Gy cohort (38% vs. 8%, respectively, p = 0.0003). The first PC of the rectal DVH was associated with late GI toxicity (odds ratio [OR], 6.91; p < 0.001), though it was not significantly stronger than standard DVH parameters such as Dmax (OR, 6.9; p < 0.001) or percentage of the organ receiving a 50% dose (V50) (OR, 5.95; p = 0 .001). Conclusions: Hypofractionated treatment with 60 Gy in 3 Gy fractions is well tolerated. There is a steep dose response curve between 60 Gy and 66 Gy for RTOG Grade {>=}2 GI effects with the dose constraints employed. Although PCA can predict late GI toxicity for patients treated with hypo-IMRT for prostate cancer, it provides no additional information

  10. A=20N (1998TI06)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    98TI06) (Not illustrated) 20N is particle stable. Its atomic mass excess is 21.770 ± 0.050 MeV (1995AU04). It has been observed in heavy-ion transfer (1989OR03) and projectile fragmentation reactions (1987GI05, 1988DUZT, 1988MU08, 1990MU06, 1991OR01) and in target fragmentation reactions (1988WO09, 1991RE02, 1993WOZZ). See also the review (1988VI1D). Mass measurements were reported in (1987GI05, 1988WO09, 1989OR03, 1991OR01, 1993WOZZ). Nuclear matter rms radii have been derived from

  11. Fail Safe Design for Large Capacity Lithium-ion Batteries

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Fail Safe Design for Large Capacity Lithium-ion Batteries NREL Commercialization & Tech Transfer Webinar March 27, 2011 Gi-Heon Kim gi-heon.kim@nrel.gov John Ireland, Kyu-Jin Lee, Ahmad Pesaran Kandler Smith kandler.smith@nrel.gov Source: A123 Source: GM NATIONAL RENEWABLE ENERGY LABORATORY Challenges for Large LIB Systems 2 * Li-ion batteries are flammable, require expensive manufacturing to reduce defects * Small-cell protection devices do not work for large systems * Difficult to detect

  12. Upper limit to magnetism in LaAIO3/SrTiO3 heterostructures

    SciTech Connect

    Fitzsimmons, Michael R.; Hengartner, N. W.; Singh, S.; Zhernenkov, M.; Bruno, F. Y.; Santamaria, J.; Brinkman, A.; Huijben, M.; Molegraaf, H.; de la Venta, J.; Schuller, Ivan K.

    2012-02-27

    In 2004 Ohtomo and Hwang reported unusually high conductivity in LaAl03 and SrTi03 bilayer samples. Since then, metallic conduction, superconductivity, magnetism, and coexistence of superconductivity and ferromagnetism have been attributed to LaAl03/SrTi03 interfaces. Very recently, two studies have reported large magnetic moments attributed to interfaces from measurement techniques that are unable to distinguish between interfacial and bulk magnetism. Consequently, it is imperative to perform magnetic measurements that by being intrinsically sensitive to interface magnetism are impervious to experimental artifacts suffered by bulk measurements. Using polarized neutron reflectometry we measured the neutron spin dependent reflectivity from four LaAl03/SrTi03 superlattices. Our results indicate the upper limit for the magnetization averaged over the lateral dimensions of the sample induced by an 11 T magnetic field at 1.7 K is less than 2 G. SQUID magnetometry of the neutron superlattice samples sporadically finds an enhanced moment (consistent with past reports), possibly due to experimental artifacts. These observations set important restrictions on theories which imply a strongly enhanced magnetism at the interface between LaAI03 and SrTi03.

  13. A=19C (1995TI07)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Isobar Diagram for 19C) 19C has been observed in the 0.8 GeV proton bombardment of thorium (1986VI09, 1988WO09) and in the fragmentation of 66 MeVA argon ions (1987GI05) and in ...

  14. A=14Be (1991AJ01)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    +)14B reaction (1984GI09), in the interaction of 30 MeVA 18O ions with 181Ta (1986CU01) and in the spallation of thorium by 800 MeV protons (1988WO09). See also (1986AJ01). ...

  15. A=19C (1987AJ02)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Isobar Diagram for 19C) 19C has been observed in the 0.8 GeV proton bombardment of thorium (1986VI09) and in the fragmentation of 60 MeVA argon ions (1987GI1E). The mass excess ...

  16. A=10Li (1988AJ01)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    MeV) corresponds to the ground state. 10Lig.s. would then be unbound with respect to breakup into 9Li + n by 0.80 0.25 MeV: see (1979AJ01). See also (1986GI10, 1987AB15),...

  17. A=20C (1987AJ02)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    7AJ02) (Not illustrated) 20C has been observed in the fragmentation of 60 MeVA argon ions: its mass excess is 37.20 1.13 MeV (1987GI1E). It is then stable with respect to 19C +...

  18. XE6_Tips_022011.pptx

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    P GI a nd C CE Use o f i nline a ssembly i s e ncouraged Focus i s m ore o n b est ... gnore vectoriza1on) Obviously, t he b est f or gcc c ompatability Scalar o ...

  19. PART I - THE SCHEDULE

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    G Contract No. DE-AC27-08RV14800 Modification No. 330 G-i PART I - THE SCHEDULE SECTION G CONTRACT ADMINISTRATION DATA TABLE OF CONTENTS G.1 CONTRACT ADMINISTRATION ....................................................................................................... 1 G.2 CORRESPONDENCE PROCEDURES ............................................................................................. 2 G.3 MODIFICATION AUTHORITY

  20. High-Dose-Rate Brachytherapy Alone for Localized Prostate Cancer in Patients at Moderate or High Risk of Biochemical Recurrence

    SciTech Connect

    Hoskin, Peter; Rojas, Ana; Lowe, Gerry; Bryant, Linda; Ostler, Peter; Hughes, Rob; Milner, Jessica; Cladd, Helen

    2012-03-15

    Purpose: To evaluate genitourinary (GU) and gastrointestinal (GI) morbidity and biochemical control of disease in patients with localized prostate adenocarcinoma treated with escalating doses per fraction of high-dose rate brachytherapy alone. Methods and Materials: A total of 197 patients were treated with 34 Gy in four fractions, 36 Gy in four fractions, 31.5 Gy in three fractions, or 26 Gy in two fractions. Median follow-up times were 60, 54, 36, and 6 months, respectively. Results: Incidence of early Grade {>=} 3 GU morbidity was 3% to 7%, and Grade 4 was 0% to 4%. During the first 12 weeks, the highest mean International Prostate Symptom Score (IPSS) value was 14, and between 6 months and 5 years it was 8. Grade 3 or 4 early GI morbidity was not observed. The 3-year actuarial rate of Grade 3 GU was 3% to 16%, and was 3% to 7% for strictures requiring surgery (4-year rate). An incidence of 1% Grade 3 GI events was seen at 3 years. Late Grade 4 GU or GI events were not observed. At 3 years, 99% of patients with intermediate-risk and 91% with high-risk disease were free of biochemical relapse (log-rank p = 0.02). Conclusions: There was no significant difference in urinary and rectal morbidity between schedules. Biochemical control of disease in patients with intermediate and high risk of relapse was good.

  1. Microsoft Word - Section G _Rev 01-23-2006_.doc

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    G Contract No. DE-AC06-05RL14655 M014 G-i PART I - THE SCHEDULE SECTION G CONTRACT ADMINISTRATION DATA TABLE OF CONTENTS G.1 CORRESPONDENCE PROCEDURES.............................................................................................1 G.2 CONTRACT ADMINISTRATION .......................................................................................................1 G.3 BILLING INSTRUCTIONS

  2. A=15O (70AJ04)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    corresponding to 15O*(5.19, 5.25, 6.15, 6.79, 6.86). See also (MA65Q). Gamma ray branding ratios are shown in Table 15.22 (in PDF or PS) (WA65J, GI68C). Lifetime measurements...

  3. A=11B (59AJ76)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    MeV, J 32-; 4.46 MeV, J 52- ((JO52D) and D.H. Wilkinson, private communication). ... formed by s or p-wave neutrons, J 52+ or 32-, n 20 keV and 300 keV (GI59). ...

  4. 9Be Cross Section

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    S-factor Ecm 0.16 - 1.87 S(E) X4 01242012 2011GI05 9Be(, n): for n1 0.3 - 7.9 linear scale, log scale 06182012 1968DA05 9Be(, n): excitation function at 0...

  5. Radiation-induced complications in prostate cancer patients treated with radiotherapy

    SciTech Connect

    Azuddin, A. Yusof; Rahman, I. Abdul; Mohamed, F.; Siah, N. J.; Saadc, M.; Ismail, F.

    2014-09-03

    The purpose of the study is to determine the relationship between radiation-induced complications with dosimetric and radiobiological parameters for prostate cancer patients that underwent the conformal radiotherapy treatment. 17 prostate cancer patients that have been treated with conformal radiotherapy were retrospectively analysed. The dosimetric data was retrieved in the form of dose-volume histogram (DVH) from Radiotherapy Treatment Planning System. The DVH was utilised to derived Normal Tissue Complication Probability (NTCP) in radiobiological data. Follow-up data from medical records were used to grade the occurrence of acute gastrointestinal (GI) and genitourinary (GU) complications using Radiation Therapy Oncology Group (RTOG) scoring system. The chi-square test was used to determine the relationship between radiation-induced complication with dosimetric and radiobiological parameters. 8 (47%) and 7 (41%) patients were having acute GI and GU complications respectively. The acute GI complication can be associated with V60{sub rectum}, rectal mean dose and NTCP{sub rectum} with p-value of 0.016, 0.038 and 0.049 respectively. There are no significant relationships of acute GU complication with dosimetric and radiobiological variables. Further study can be done by increase the sample size and follow up duration for deeper understanding of the factors that effecting the GU and GI complication in prostate cancer radiotherapy.

  6. Quality of Life and Toxicity From Passively Scattered and Spot-Scanning Proton Beam Therapy for Localized Prostate Cancer

    SciTech Connect

    Pugh, Thomas J. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Munsell, Mark F. [Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Choi, Seungtaek; Nguyen, Quyhn Nhu; Mathai, Benson [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Zhu, X. Ron; Sahoo, Narayan; Gillin, Michael; Johnson, Jennifer L.; Amos, Richard A. [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Dong, Lei [Scripps Proton Therapy Center, San Diego, California (United States); Mahmood, Usama; Kuban, Deborah A.; Frank, Steven J.; Hoffman, Karen E.; McGuire, Sean E. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Lee, Andrew K., E-mail: aklee@mdanderson.org [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2013-12-01

    Purpose: To report quality of life (QOL)/toxicity in men treated with proton beam therapy for localized prostate cancer and to compare outcomes between passively scattered proton therapy (PSPT) and spot-scanning proton therapy (SSPT). Methods and Materials: Men with localized prostate cancer enrolled on a prospective QOL protocol with a minimum of 2 years' follow-up were reviewed. Comparative groups were defined by technique (PSPT vs SSPT). Patients completed Expanded Prostate Cancer Index Composite questionnaires at baseline and every 3-6 months after proton beam therapy. Clinically meaningful differences in QOL were defined as ?0.5 baseline standard deviation. The cumulative incidence of modified Radiation Therapy Oncology Group grade ?2 gastrointestinal (GI) or genitourinary (GU) toxicity and argon plasma coagulation were determined by the Kaplan-Meier method. Results: A total of 226 men received PSPT, and 65 received SSPT. Both PSPT and SSPT resulted in statistically significant changes in sexual, urinary, and bowel Expanded Prostate Cancer Index Composite summary scores. Only bowel summary, function, and bother resulted in clinically meaningful decrements beyond treatment completion. The decrement in bowel QOL persisted through 24-month follow-up. Cumulative grade ?2 GU and GI toxicity at 24 months were 13.4% and 9.6%, respectively. There was 1 grade 3 GI toxicity (PSPT group) and no other grade ?3 GI or GU toxicity. Argon plasma coagulation application was infrequent (PSPT 4.4% vs SSPT 1.5%; P=.21). No statistically significant differences were appreciated between PSPT and SSPT regarding toxicity or QOL. Conclusion: Both PSPT and SSPT confer low rates of grade ?2 GI or GU toxicity, with preservation of meaningful sexual and urinary QOL at 24 months. A modest, yet clinically meaningful, decrement in bowel QOL was seen throughout follow-up. No toxicity or QOL differences between PSPT and SSPT were identified. Long-term comparative results in a larger patient

  7. Transjugular Endovascular Recanalization of Splenic Vein in Patients with Regional Portal Hypertension Complicated by Gastrointestinal Bleeding

    SciTech Connect

    Luo, Xuefeng; Nie, Ling; Wang, Zhu; Tsauo, Jiaywei; Tang, Chengwei; Li, Xiao

    2013-05-02

    PurposeRegional portal hypertension (RPH) is an uncommon clinical syndrome resulting from splenic vein stenosis/occlusion, which may cause gastrointestinal (GI) bleeding from the esophagogastric varices. The present study evaluated the safety and efficacy of transjugular endovascular recanalization of splenic vein in patients with GI bleeding secondary to RPH.MethodsFrom December 2008 to May 2011, 11 patients who were diagnosed with RPH complicated by GI bleeding and had undergone transjugular endovascular recanalization of splenic vein were reviewed retrospectively. Contrast-enhanced computed tomography revealed splenic vein stenosis in six cases and splenic vein occlusion in five. Etiology of RPH was chronic pancreatitis (n=7), acute pancreatitis with pancreatic pseudocyst (n=2), pancreatic injury (n=1), and isolated pancreatic tuberculosis (n=1).ResultsTechnical success was achieved in 8 of 11 patients via the transjugular approach, including six patients with splenic vein stenosis and two patients with splenic vein occlusion. Two patients underwent splenic vein venoplasty only, whereas four patients underwent bare stents deployment and two covered stents. Splenic vein pressure gradient (SPG) was reduced from 21.57.3 to 2.91.4mmHg after the procedure (P<0.01). For the remaining three patients who had technical failures, splenic artery embolization and subsequent splenectomy was performed. During a median follow-up time of 17.5 (range, 334)months, no recurrence of GI bleeding was observed.ConclusionsTransjugular endovascular recanalization of splenic vein is a safe and effective therapeutic option in patients with RPH complicated by GI bleeding and is not associated with an increased risk of procedure-related complications.

  8. A=16N (1971AJ02)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    1AJ02) (See Energy Level Diagrams for 16N) GENERAL: See also Table 16.2 [Table of Energy Levels] (in PDF or PS). Model calculations: (1957EL1B, 1957WI1E, 1959FA1C, 1960RA1A, 1960SH1A, 1960TA1C, 1961BA1F, 1962TA1E, 1964FE02, 1964LE20, 1964ST1B, 1965GI1B, 1966CO1G, 1966CO1H, 1966LE1H, 1966SL1A, 1966TO04, 1967DI1B, 1969BO37, 1969HO1U). Reactions involving muons and pions: (1963CO1B, 1964AS1A, 1964BA1M, 1964BA1N, 1964CO1C, 1965DE1K, 1965GI1C, 1965JA1E, 1966KI1C, 1966OH1A, 1966WA1K, 1967DE1R,

  9. A=20N (1987AJ02)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    7AJ02) (Not illustrated) 20N is particle stable. Its atomic mass excess is 21.64 ± 0.26 MeV (1986VI09), 22.20 ± 0.36 MeV (1986GI10), 21.62 ± 0.14 MeV (1987GI1E). We adopt 21.62 ± 0.14 MeV. 20N is then stable with respect to 19N + n by 2.32 MeV (see 19N). The half-life of 20N is 100+30-20 msec, Pn ~ 61% (1987MU1J; prelim.). See also (1984KL06; theor.). See also (1985PIZZ, 1986PI09), (1983WI1A, 1984HI1A, 1986AN07, 1986GU1D) and (1983ANZQ; theor.

  10. "Omics of the mammalian gut new insights into function

    SciTech Connect

    Lamendella, Regina; Verberkmoes, Nathan C; Jansson, Janet

    2012-01-01

    To understand the role of gut microbes in host health, it is imperative to probe their genetic potential, expression, and ecological status. The current high-throughput sequencing revolution, in addition to advances in mass spectrometry-based proteomics, have recently enabled deep access to these complex environments, and are revealing important insights into the roles of the gastrointestinal (GI) microbiota in host physiology and health. This review discusses examples of how the integration of cutting-edge meta-omics technologies are providing new knowledge about the relationships between host health status in mammals and the microbes inhabiting the GI tract. In addition, we address some promises that these techniques hold for future therapeutic and diagnostic applications.

  11. Slide 1

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    and Development of A Small Instrument To Investigate Airborne Aerosols Catherine F. Cahill Associate Professor Geophysical Institute and Department of Chemistry & Biochemistry University of Alaska Fairbanks Phone: 907-474-6905 Email: ffcfc@uaf.edu October 16, 2008 Gregory W. Walker Manager Poker Flat Research Range Geophysical Institute University of Alaska Fairbanks Phone: 907-455-2102 Email: Gregory.Walker@gi.alaska.edu In support of the US Army Research Laboratory Conducting Marine Mammal

  12. Molecular Analysis of Asymptomatic Bacteriuria Escherichia coli Strain VR50 Reveals Adaptation to the Urinary Tract by Gene Acquisition

    DOE PAGES [OSTI]

    Beatson, Scott A.; Ben Zakour, Nouri L.; Totsika, Makrina; Forde, Brian M.; Watts, Rebecca E.; Mabbett, Amanda N.; Szubert, Jan M.; Sarkar, Sohinee; Phan, Minh-Duy; Peters, Kate M.; et al

    2015-05-01

    Urinary tract infections (UTIs) are among the most common infectious diseases of humans, with Escherichia coli for >80% of all cases. One extreme of UTI is asymptomatic bacteriuria (ABU), which occurs as an asymptomatic carrier state that resembles commensalism. Here, to understand the evolution and molecular mechanisms that underpin ABU, the genome of the ABU E. coli strain VR50 was sequenced. Analysis of the complete genome indicated that it most resembles E. coli K-12, with the addition of a 94-kb genomic island (GI-VR50-pheV), eight prophages, and multiple plasmids. GI-VR50-pheV has a mosaic structure and contains genes encoding a number ofmore » UTI-associated virulence factors, namely, Afa (afimbrial adhesin), two autotransporter proteins (Ag43 and Sat), and aerobactin. We demonstrated that the presence of this island in VR50 confers its ability to colonize the murine bladder, as a VR50 mutant with GI-VR50-pheV deleted was attenuated in a mouse model of UTI in vivo. We established that Afa is the island-encoded factor responsible for this phenotype using two independent deletion (Afa operon and AfaE adhesin) mutants. E. coli VR50afa and VR50afaE displayed significantly decreased ability to adhere to human bladder epithelial cells. In the mouse model of UTI, VR50afa and VR50afaE displayed reduced bladder colonization compared to wild-type VR50, similar to the colonization level of the GI-VR50-pheV mutant. In conlusion, our study suggests that E. coli VR50 is a commensal-like strain that has acquired fitness factors that facilitate colonization of the human bladder.« less

  13. Molecular Analysis of Asymptomatic Bacteriuria Escherichia coli Strain VR50 Reveals Adaptation to the Urinary Tract by Gene Acquisition

    SciTech Connect

    Beatson, Scott A.; Ben Zakour, Nouri L.; Totsika, Makrina; Forde, Brian M.; Watts, Rebecca E.; Mabbett, Amanda N.; Szubert, Jan M.; Sarkar, Sohinee; Phan, Minh-Duy; Peters, Kate M.; Petty, Nicola K.; Alikhan, Nabil-Fareed; Sullivan, Mitchell J.; Gawthorne, Jayde A.; Stanton-Cook, Mitchell; Nhu, Nguyen Thi Khanh; Chong, Teik Min; Yin, Wai-Fong; Chan, Kok-Gan; Hancock, Viktoria; Ussery, David W.; Ulett, Glen C.; Schembri, Mark A

    2015-05-01

    Urinary tract infections (UTIs) are among the most common infectious diseases of humans, with Escherichia coli for >80% of all cases. One extreme of UTI is asymptomatic bacteriuria (ABU), which occurs as an asymptomatic carrier state that resembles commensalism. Here, to understand the evolution and molecular mechanisms that underpin ABU, the genome of the ABU E. coli strain VR50 was sequenced. Analysis of the complete genome indicated that it most resembles E. coli K-12, with the addition of a 94-kb genomic island (GI-VR50-pheV), eight prophages, and multiple plasmids. GI-VR50-pheV has a mosaic structure and contains genes encoding a number of UTI-associated virulence factors, namely, Afa (afimbrial adhesin), two autotransporter proteins (Ag43 and Sat), and aerobactin. We demonstrated that the presence of this island in VR50 confers its ability to colonize the murine bladder, as a VR50 mutant with GI-VR50-pheV deleted was attenuated in a mouse model of UTI in vivo. We established that Afa is the island-encoded factor responsible for this phenotype using two independent deletion (Afa operon and AfaE adhesin) mutants. E. coli VR50afa and VR50afaE displayed significantly decreased ability to adhere to human bladder epithelial cells. In the mouse model of UTI, VR50afa and VR50afaE displayed reduced bladder colonization compared to wild-type VR50, similar to the colonization level of the GI-VR50-pheV mutant. In conlusion, our study suggests that E. coli VR50 is a commensal-like strain that has acquired fitness factors that facilitate colonization of the human bladder.

  14. Risk factors of late rectal bleeding after carbon ion therapy for prostate cancer

    SciTech Connect

    Ishikawa, Hitoshi; Tsuji, Hiroshi . E-mail: h_tsuji@nirs.go.jp; Kamada, Tadashi; Hirasawa, Naoki; Yanagi, Takeshi; Mizoe, Jun-Etsu; Akakura, Koichiro; Suzuki, Hiroyoshi; Shimazaki, Jun; Tsujii, Hirohiko

    2006-11-15

    Purpose: The aim of this study was to determine the risk factors for late gastrointestinal (GI) morbidity after hypofractionated carbon ion radiotherapy (C-ion RT) for prostate cancer. Methods and Materials: Between April 2000 and November 2003, a Phase II clinical trial of C-ion RT with a total dose of 66 GyE in 20 fractions was performed on 175 patients with prostate cancer, and the correlations of clinical and dosimetric parameters with the incidence of late GI toxicity in 172 patients who survived for more than 18 months were investigated. Results: Although no Grade 3-4 late morbidities of the rectum were observed, Grade 1 and 2 morbidities developed in 23 (13%) and 4 (2%) patients, respectively. Dose-volume histogram analysis revealed that the percentage of rectal volume receiving 50% of the prescribed dose (V50) was significantly higher in patients with rectal toxicity than without toxicity (13.2 {+-} 5.6% with toxicity; 11.4 {+-} 4.0% without toxicity, p = 0.046). Multivariate analysis demonstrated that the use of anticoagulation therapy (p = 0.010) and rectal V50 (p = 0.012) were significant risk factors for the occurrence of Grade 1-2 late GI toxicity. Conclusions: Although C-ion RT with hypofractionation yielded favorable results regarding late GI complication, dosimetric parameter was a very important factor in the occurrence of rectal bleeding after C-ion RT as well as photon beam RT. Our results provide useful information for physicians applying charged particle RT in the treatment of prostate cancer.

  15. Word Pro - A

    Energy Information Administration (EIA) (indexed site)

    6 U.S. Energy Information Administration / Monthly Energy Review October 2016 Table A6. Approximate Heat Rates for Electricity, and Heat Content of Electricity (Btu per Kilowatthour) Approximate Heat Rates a for Electricity Net Generation Heat Content j of Electricity k Fossil Fuels b Nuclear h Noncombustible Renewable Energy g,i Coal c Petroleum d Natural Gas e Total Fossil Fuels f,g 1950 .............................. NA NA NA 14,030 - - 14,030 3,412 1955 .............................. NA NA

  16. Microsoft Word - Attachment G1G 10-1-2012.docx

    Office of Environmental Management (EM)

    G1 APPENDIX G TECHNICAL SPECIFICATIONS PANEL CLOSURE SYSTEM WASTE ISOLATION PILOT PLANT CARLSBAD, NEW MEXICO Waste Isolation Pilot Plant Hazardous Waste Permit October 1, 2012 (This page intentionally blank) Waste Isolation Pilot Plant Hazardous Waste Permit October 1, 2012 PERMIT ATTACHMENT G1G Page G1G-i ATTACHMENT G1 APPENDIX G TECHNICAL SPECIFICATIONS PANEL CLOSURE SYSTEM WASTE ISOLATION PILOT PLANT CARLSBAD, NEW MEXICO TABLE OF CONTENTS DIVISION 1 - GENERAL REQUIREMENTS

  17. GRAVITATIONAL INSTABILITY OF ROTATING, PRESSURE-CONFINED, POLYTROPIC GAS DISKS WITH VERTICAL STRATIFICATION

    SciTech Connect

    Kim, Jeong-Gyu; Kim, Woong-Tae; Seo, Young Min; Hong, Seung Soo E-mail: wkim@astro.snu.ac.kr E-mail: sshong@astro.snu.ac.kr

    2012-12-20

    We investigate the gravitational instability (GI) of rotating, vertically stratified, pressure-confined, polytropic gas disks using a linear stability analysis as well as analytic approximations. The disks are initially in vertical hydrostatic equilibrium and bounded by a constant external pressure. We find that the GI of a pressure-confined disk is in general a mixed mode of the conventional Jeans and distortional instabilities, and is thus an unstable version of acoustic-surface-gravity waves. The Jeans mode dominates in weakly confined disks or disks with rigid boundaries. On the other hand, when the disk has free boundaries and is strongly pressure confined, the mixed GI is dominated by the distortional mode that is surface-gravity waves driven unstable under their own gravity and thus incompressible. We demonstrate that the Jeans mode is gravity-modified acoustic waves rather than inertial waves and that inertial waves are almost unaffected by self-gravity. We derive an analytic expression for the effective sound speed c{sub eff} of acoustic-surface-gravity waves. We also find expressions for the gravity reduction factors relative to a razor-thin counterpart that are appropriate for the Jeans and distortional modes. The usual razor-thin dispersion relation, after correcting for c{sub eff} and the reduction factors, closely matches the numerical results obtained by solving a full set of linearized equations. The effective sound speed generalizes the Toomre stability parameter of the Jeans mode to allow for the mixed GI of vertically stratified, pressure-confined disks.

  18. Resources for Veterans | Y-12 National Security Complex

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Resources for Veterans Resources for Veterans The CNS Veterans Program STEM initiative is a valuable resource for our nation's veterans. Check out some of the other resources available. In Tennessee Anderson County, Tennessee, Veterans Office Tennessee Department of Veterans Affairs Tennessee Lottery Tuition Support Program In Texas Texas State Veterans Benefits Texas Lottery Tuition Support Program Across the U.S. Student Veterans of America National Resource Directory Today's GI Bill website

  19. PowerPoint Presentation

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Arid Lands Green Infrastructure Regional Examples + Tour Green Infrastructure and Low-Impact Design for Stormwater Management July 12, 2012 Erin English, PE LEED AP Biohabitats/Natural Systems International Principles of GI/LID Think like a watershed Infiltrate, evapotranspirate and slow down runoff Minimize erosion and sediment transport Treat stormwater close to the source Use pervious areas for stormwater Treatment Water Harvesting within the landscape Regional Examples * Emerging approach in

  20. A Phase 1/2 Trial of Brief Androgen Suppression and Stereotactic Radiation Therapy (FASTR) for High-Risk Prostate Cancer

    SciTech Connect

    Bauman, Glenn; Ferguson, Michelle; Lock, Michael; Chen, Jeff; Ahmad, Belal; Venkatesan, V.M.; Sexton, Tracy; D'Souza, David; Loblaw, Andrew; Warner, Andrew; Rodrigues, George

    2015-07-15

    Purpose: To initiate a phase 1/2 trial to examine the tolerability of a condensed combined-modality protocol for high-risk prostate cancer. Methods and Materials: Men scoring ≥3 on the Vulnerable Elderly Scale (VES) or refusing conventionally fractionated treatment for high-risk prostate cancer were eligible to participate. Androgen suppression was delivered for 12 months, and radiation therapy was delivered using 25 Gy to pelvic nodes delivered synchronously with 40 Gy to the prostate given as 1 fraction per week over 5 weeks. The phase 1 component included predetermined stopping rules based on 6-month treatment-related toxicity, with trial suspension specified if there were ≥6 of 15 patients (40%) or ≥3 of 15 (20%) who experienced grade ≥2 or ≥3 gastrointestinal (GI) or genitourinary (GU) toxicity, respectively. Results: Sixteen men were enrolled, with 7 men meeting the criteria of VES ≥3 and 9 men having a VES <3 but choosing the condensed treatment. One man was not treated owing to discovery of a synchronous primary rectal cancer. Four patients (26%) experienced grade ≥2 toxicity at 6 weeks after treatment. There were 9 of 15 (60%) who experienced grade ≥2 GI or GU toxicity and 4 of 15 (26%) grade ≥3 GI or GU toxicity at 6 months, and 5 of 15 (30%) grade ≥2 GI and GU toxicity at 6 months. A review of the 15 cases did not identify any remedial changes, thus the phase 1 criteria were not met. Conclusion: This novel condensed treatment had higher than anticipated late toxicities and was terminated before phase 2 accrual. Treatment factors, such as inclusion of pelvic lymph node radiation therapy, planning constraints, and treatment margins, or patient factors related to the specific frail elderly population may be contributing.

  1. Predictors of Postoperative Complications After Trimodality Therapy for Esophageal Cancer

    SciTech Connect

    Wang, Jingya [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Wei, Caimiao [Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Tucker, Susan L. [Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Myles, Bevan; Palmer, Matthew [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Hofstetter, Wayne L.; Swisher, Stephen G. [Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Ajani, Jaffer A. [Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Cox, James D.; Komaki, Ritsuko; Liao, Zhongxing [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Lin, Steven H., E-mail: SHLin@mdanderson.org [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2013-08-01

    Purpose: While trimodality therapy for esophageal cancer has improved patient outcomes, surgical complication rates remain high. The goal of this study was to identify modifiable factors associated with postoperative complications after neoadjuvant chemoradiation. Methods and Materials: From 1998 to 2011, 444 patients were treated at our institution with surgical resection after chemoradiation. Postoperative (pulmonary, gastrointestinal [GI], cardiac, wound healing) complications were recorded up to 30 days postoperatively. Kruskal-Wallis tests and ?{sup 2} or Fisher exact tests were used to assess associations between continuous and categorical variables. Multivariate logistic regression tested the association between perioperative complications and patient or treatment factors that were significant on univariate analysis. Results: The most frequent postoperative complications after trimodality therapy were pulmonary (25%) and GI (23%). Lung capacity and the type of radiation modality used were independent predictors of pulmonary and GI complications. After adjusting for confounding factors, pulmonary and GI complications were increased in patients treated with 3-dimensional conformal radiation therapy (3D-CRT) versus intensity modulated radiation therapy (IMRT; odds ratio [OR], 2.018; 95% confidence interval [CI], 1.104-3.688; OR, 1.704; 95% CI, 1.03-2.82, respectively) and for patients treated with 3D-CRT versus proton beam therapy (PBT; OR, 3.154; 95% CI, 1.365-7.289; OR, 1.55; 95% CI, 0.78-3.08, respectively). Mean lung radiation dose (MLD) was strongly associated with pulmonary complications, and the differences in toxicities seen for the radiation modalities could be fully accounted for by the MLD delivered by each of the modalities. Conclusions: The radiation modality used can be a strong mitigating factor of postoperative complications after neoadjuvant chemoradiation.

  2. ARM - Publications: Science Team Meeting Documents

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Empirical Model of Aerosol Uplifting from the Arid Area Gorchakov, G.I., Shukurov, K.A., and Golitsyn, G.S., A.M. Obukhov Institute of Atmospheric Physics, RAS Thirteenth Atmospheric Radiation Measurement (ARM) Science Team Meeting The model enables to make the estimates of the vertical fluxes of arid aerosol using measured data of the wind velocity. The model includes the following main elements: 1. The parameterization of the microstructure of the aerosol uplifted from the area. 2.

  3. Dosimetry and preliminary acute toxicity in the first 100 men treated for prostate cancer on a randomized hypofractionation dose escalation trial

    SciTech Connect

    Pollack, Alan . E-mail: Alan.Pollack@FCCC.edu; Hanlon, Alexandra L.; Horwitz, Eric M.; Feigenberg, Steven J.; Konski, Andre A.; Movsas, Benjamin; Greenberg, Richard E.; Uzzo, Robert G.; Ma, C.-M. Charlie; McNeeley, Shawn W.; Buyyounouski, Mark K.; Price, Robert A.

    2006-02-01

    Purpose: The {alpha}/{beta} ratio for prostate cancer is postulated to be between 1 and 3, giving rise to the hypothesis that there may be a therapeutic advantage to hypofractionation. The dosimetry and acute toxicity are described in the first 100 men enrolled in a randomized trial. Patients and Methods: The trial compares 76 Gy in 38 fractions (Arm I) to 70.2 Gy in 26 fractions (Arm II) using intensity modulated radiotherapy. The planning target volume (PTV) margins in Arms I and II were 5 mm and 3 mm posteriorly and 8 mm and 7 mm in all other dimensions. The PTV D95% was at least the prescription dose. Results: The mean PTV doses for Arms I and II were 81.1 and 73.8 Gy. There were no differences in overall maximum acute gastrointestinal (GI) or genitourinary (GU) toxicity acutely. However, there was a slight but significant increase in Arm II GI toxicity during Weeks 2, 3, and 4. In multivariate analyses, only the combined rectal DVH parameter of V65 Gy/V50 Gy was significant for GI toxicity and the bladder volume for GU toxicity. Conclusion: Hypofractionation at 2.7 Gy per fraction to 70.2 Gy was well tolerated acutely using the planning conditions described.

  4. NRG Oncology Radiation Therapy Oncology Group 0822: A Phase 2 Study of Preoperative Chemoradiation Therapy Using Intensity Modulated Radiation Therapy in Combination With Capecitabine and Oxaliplatin for Patients With Locally Advanced Rectal Cancer

    SciTech Connect

    Hong, Theodore S.; Moughan, Jennifer; Garofalo, Michael C.; Bendell, Johanna; Berger, Adam C.; Oldenburg, Nicklas B.E.; Anne, Pramila Rani; Perera, Francisco; Jabbour, Salma K.; Nowlan, Adam; DeNittis, Albert; Crane, Christopher

    2015-09-01

    Purpose: To evaluate the rate of gastrointestinal (GI) toxicity of neoadjuvant chemoradiation with capecitabine, oxaliplatin, and intensity modulated radiation therapy (IMRT) in cT3-4 rectal cancer. Methods and Materials: Patients with localized, nonmetastatic T3 or T4 rectal cancer <12 cm from the anal verge were enrolled in a prospective, multi-institutional, single-arm study of preoperative chemoradiation. Patients received 45 Gy with IMRT in 25 fractions, followed by a 3-dimensional conformal boost of 5.4 Gy in 3 fractions with concurrent capecitabine/oxaliplatin (CAPOX). Surgery was performed 4 to 8 weeks after the completion of therapy. Patients were recommended to receive FOLFOX chemotherapy after surgery. The primary endpoint of the study was acute grade 2 to 5 GI toxicity. Seventy-one patients provided 80% probability to detect at least a 12% reduction in the specified GI toxicity with the treatment of CAPOX and IMRT, at a significance level of .10 (1-sided). Results: Seventy-nine patients were accrued, of whom 68 were evaluable. Sixty-one patients (89.7%) had cT3 disease, and 37 (54.4%) had cN (+) disease. Postoperative chemotherapy was given to 42 of 68 patients. Fifty-eight patients had target contours drawn per protocol, 5 patients with acceptable variation, and 5 patients with unacceptable variations. Thirty-five patients (51.5%) experienced grade ≥2 GI toxicity, 12 patients (17.6%) experienced grade 3 or 4 diarrhea, and pCR was achieved in 10 patients (14.7%). With a median follow-up time of 3.98 years, the 4-year rate of locoregional failure was 7.4% (95% confidence interval [CI]: 1.0%-13.7%). The 4-year rates of OS and DFS were 82.9% (95% CI: 70.1%-90.6%) and 60.6% (95% CI: 47.5%-71.4%), respectively. Conclusion: The use of IMRT in neoadjuvant chemoradiation for rectal cancer did not reduce the rate of GI toxicity.

  5. The complete mitochondrial sequence of the"living fossil" Tricholepidion gertschi: structure, phylogenetic implications, and the description of a novel A/T asymmetrical bias

    SciTech Connect

    Nardi, F.; Frati, F.; Carapelli, A.; Dallai, R.; Boore, J.

    2002-06-23

    the evolution and differentiation of the most basal hexapod groups, including Tricholepidion. Mitochondrial genomics, that is analysis of various features of the mitochondrial genome such as gene order and the analysis of the concatenated sequence of its genes, has proved to be a very powerful tool for the study of ancient phylogenetic relationships (Boore, 2000; Boore and Brown, 1995; Boore and Brown, 1998; Garcia-Machado et al., 1999; Hwang et al., 2001; Nardi et al., 2001), and its application seems to be appropriate for the problem under study ((Nardi et al., 2001), this study). In addition, complete mitochondrial sequences, with the advent of automatic sequencing tools, are accumulating rapidly, but there is a strong bias towards the better known or economically important groups, while only two sequences have been produced for the more basal, and evolutionarily more intriguing, hexapod orders. The complete sequence of the mitochondrial genome of Tricholepidion gertschi is the second among apterygotans, following the collembolan T.bielanensis (Nardi et al., 2001).

  6. Oligofructose protects against arsenic-induced liver injury in a model of environment/obesity interaction

    SciTech Connect

    Massey, Veronica L.; Stocke, Kendall S.; Schmidt, Robin H.; Tan, Min; Ajami, Nadim; Neal, Rachel E.; Petrosino, Joseph F.; Barve, Shirish; Arteel, Gavin E.

    2015-05-01

    Arsenic (As) tops the ATSDR list of hazardous environmental chemicals and is known to cause liver injury. Although the concentrations of As found in the US water supply are generally too low to directly damage the liver, subhepatotoxic doses of As sensitize the liver to experimental NAFLD. It is now suspected that GI microbiome dysbiosis plays an important role in development of NALFD. Importantly, arsenic has also been shown to alter the microbiome. The purpose of the current study was to test the hypothesis that the prebiotic oligofructose (OFC) protects against enhanced liver injury caused by As in experimental NAFLD. Male C57Bl6/J mice were fed low fat diet (LFD), high fat diet (HFD), or HFD containing oligofructose (OFC) during concomitant exposure to either tap water or As-containing water (4.9 ppm as sodium arsenite) for 10 weeks. HFD significantly increased body mass and caused fatty liver injury, as characterized by an increased liver weight-to-body weight ratio, histologic changes and transaminases. As observed previously, As enhanced HFD-induced liver damage, which was characterized by enhanced inflammation. OFC supplementation protected against the enhanced liver damage caused by As in the presence of HFD. Interestingly, arsenic, HFD and OFC all caused unique changes to the gut flora. These data support previous findings that low concentrations of As enhance liver damage caused by high fat diet. Furthermore, these results indicate that these effects of arsenic may be mediated, at least in part, by GI tract dysbiosis and that prebiotic supplementation may confer significant protective effects. - Highlights: • Arsenic (As) enhances liver damage caused by a high-fat (HFD) diet in mice. • Oligofructose protects against As-enhanced liver damage caused by HFD. • As causes dysbiosis in the GI tract and exacerbates the dysbiosis caused by HFD. • OFC prevents the dysbiosis caused by HFD and As, increasing commensal bacteria.

  7. Toward an ontology framework supporting the integration of geographic information with modeling and simulation for critical infrastructure protection

    SciTech Connect

    Ambrosiano, John J; Bent, Russell W; Linger, Steve P

    2009-01-01

    Protecting the nation's infrastructure from natural disasters, inadvertent failures, or intentional attacks is a major national security concern. Gauging the fragility of infrastructure assets, and understanding how interdependencies across critical infrastructures affect their behavior, is essential to predicting and mitigating cascading failures, as well as to planning for response and recovery. Modeling and simulation (M&S) is an indispensable part of characterizing this complex system of systems and anticipating its response to disruptions. Bringing together the necessary components to perform such analyses produces a wide-ranging and coarse-grained computational workflow that must be integrated with other analysis workflow elements. There are many points in both types of work flows in which geographic information (GI) services are required. The GIS community recognizes the essential contribution of GI in this problem domain as evidenced by past OGC initiatives. Typically such initiatives focus on the broader aspects of GI analysis workflows, leaving concepts crucial to integrating simulations within analysis workflows to that community. Our experience with large-scale modeling of interdependent critical infrastructures, and our recent participation in a DRS initiative concerning interoperability for this M&S domain, has led to high-level ontological concepts that we have begun to assemble into an architecture that spans both computational and 'world' views of the problem, and further recognizes the special requirements of simulations that go beyond common workflow ontologies. In this paper we present these ideas, and offer a high-level ontological framework that includes key geospatial concepts as special cases of a broader view.

  8. The Superoxide Reductase from the Early Diverging Eukaryote Giardia Intestinalis

    SciTech Connect

    Cabelli, D.E.; Testa, F.; Mastronicola, D.; Bordi, E.; Pucillo, L.P.; Sarti, P.; Saraiva, L.M.; Giuffre, A.; Teixeira, M.

    2011-10-15

    Unlike superoxide dismutases (SODs), superoxidereductases (SORs) eliminate superoxide anion (O{sub 2}{sup {sm_bullet}-}) not through its dismutation, but via reduction to hydrogen peroxide (H{sub 2}O{sub 2}) in the presence of an electron donor. The microaerobic protist Giardia intestinalis, responsible for a common intestinal disease in humans, though lacking SOD and other canonical reactive oxygen species-detoxifying systems, is among the very few eukaryotes encoding a SOR yet identified. In this study, the recombinant SOR from Giardia (SOR{sub Gi}) was purified and characterized by pulse radiolysis and stopped-flow spectrophotometry. The protein, isolated in the reduced state, after oxidation by superoxide or hexachloroiridate(IV), yields a resting species (T{sub final}) with Fe{sup 3+} ligated to glutamate or hydroxide depending on pH (apparent pK{sub a} = 8.7). Although showing negligible SOD activity, reduced SOR{sub Gi} reacts with O{sub 2}{sup {sm_bullet}-} with a pH-independent second-order rate constant k{sub 1} = 1.0 x 10{sup 9} M{sup -1} s{sup -1} and yields the ferric-(hydro)peroxo intermediate T{sub 1}; this in turn rapidly decays to the T{sub final} state with pH-dependent rates, without populating other detectable intermediates. Immunoblotting assays show that SOR{sub Gi} is expressed in the disease-causing trophozoite of Giardia. We propose that the superoxide-scavenging activity of SOR in Giardia may promote the survival of this air-sensitive parasite in the fairly aerobic proximal human small intestine during infection.

  9. JJ'

    Office of Legacy Management (LM)

    ^x .,.,..,,, .,_...,,, .~, .~~ ,.,_,. _ . . ^..~ .,.-....-.. ~.~ .,,_,_ I-.~ ___:-._ ,,_ I --,,,,-.I I -... "I _-_,, i ,,,, (__. ..-;.mss,.r^-' . :' _.' i' . ' . r*911;&& --- _. JJ' 4)&-] " ]+-ic 7-g &Lc u.4 u - 7 S' JJ-- ,C- iki?rdC~L\T $' Y' IEThLS COP?O~,~TION d - I8 4.1 INROAD STREET (In ciuplicste) Xovezber 30, 1942. The I)ist?ict Eng~Gi U. S. EZi<i3eef Office, 2Zi%XttZ?l Cistrict, ? . 0 . z,ox 42, CL',t'~~'.' -~-~: ~,'y:-y;, :.yz --'- -- Station F., ,y: r:

  10. Richard Gerber, Helen He, Zhengji Zhao, David Turner NUG Monthly

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Helen He, Zhengji Zhao, David Turner NUG Monthly Meeting --- 1 --- NUG M onthly M ee-ng November 13, 2014 Agenda * Tuesday's Q uarterly M aintenance * Hopper and Edison Status Updates * NUGEX Elec-ons * NUG 2 015 M ee-ng P lanning * Training U pdate * User Survey * Queue C ommiJee T opics --- 2 --- Quarterly Maintenance Summary" David Turner, NERSC User Services --- 3 --- Maintenance: November 11, 2014 * Quarterly m aintenance - Originally t o a ccommodate J GI s equencer o pera;ons -

  11. A=8B (1988AJ01)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    8AJ01) (See Energy Level Diagrams for 8B) GENERAL: See also (1984AJ01) and Table 8.9 [Table of Energy Levels] (in PDF or PS) here. Model calculations: (1983SH38). Special states: (1982PO12, 1988KH03). Complex reactions involving 8B: (1982AL08, 1983OL1A, 1984GR08, 1986HA1B, 1987TAZU, 1988AR05, 1988KI05). Astrophysical questions: (1984HA1B, 1985BO1E, 1985GI1C, 1985KL1A, 1985LA1C, 1988BA86). Reactions involving pions: (1983SP06). Hypernuclei: (1983SH38). Other topics: (1985AN28). Ground state of

  12. 06-DataManagement-Gerhardt.pdf

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    New User Training! July 15, 2014 Data Management at NERSC Where Do I Put My Data? --- 2 --- * Overview o f N ERSC fi le s ystems - Local v s. G lobal - Permanent v s. P urged * HPSS A rchive S ystem - What i s i t a nd h ow t o u se i t * Data S haring NERSC File Systems --- 3 --- The compute and storage systems 2014 Produc<on C lusters Carver, P DSF, J GI, MatComp, Planck /global/ scratch 4 PB /project 5 PB /home 250 TB 65 PB stored, 240 PB capacity, 4 0 y ears o f community d ata HPSS 16 x

  13. DOE/EIA-0376(2014)

    Gasoline and Diesel Fuel Update

    376(2014) June 2016 State Energy Price and Expenditure Estimates 1970 Through 2014 2014 Price and Expenditure Summary Tables S U M M A R I E S U.S. Energy Information Administration | State Energy Data 2014: Prices and Expenditures 3 Table E1. Primary Energy, Electricity, and Total Energy Price Estimates, 2014 (Dollars per Million Btu) State Primary Energy Electric Power Sector g,h Retail Electricity Total Energy g,i Coal Natural Gas a Petroleum Nuclear Fuel Biomass Total g,h,i Distillate Fuel

  14. Joint Facilities User Forum on Data Intensive Computing Lessons Learned

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    User Forum on Data Intensive Computing Lessons Learned - NERSC/JGI Partnership Kjiersten Fagnan, NERSC User Services/JGI --- 1 --- June 1 7, 2 013 Outline * Overview o f N ERSC/JGI P artnership - DOE J GI b ackground - Team o verview - Compute r esources * CompuBng S trategic P lan - JGI G oals - NERSC G oals * Lessons Learned --- 2 --- DOE Joint Genome Institute 3 DOE JGI, Serving as a genomic user facility in support of the DOE missions: * Walnut Creek, CA facility opened in 1999 * 250

  15. Urethra-Sparing, Intraoperative, Real-Time Planned, Permanent-Seed Prostate Brachytherapy: Toxicity Analysis

    SciTech Connect

    Zilli, Thomas; Taussky, Daniel; Donath, David; Le, Hoa Phong; Larouche, Renee-Xaviere; Beliveau-Nadeau, Dominique; Hervieux, Yannick; Delouya, Guila

    2011-11-15

    Purpose: To report the toxicity outcome in patients with localized prostate cancer undergoing {sup 125}I permanent-seed brachytherapy (BT) according to a urethra-sparing, intraoperative (IO), real-time planned conformal technique. Methods and Materials: Data were analyzed on 250 patients treated consecutively for low- or intermediate-risk prostate cancer between 2005 and 2009. The planned goal was urethral V{sub 150} = 0. Acute and late genitourinary (GU), gastrointestinal (GI), and erectile toxicities were scored with the International Prostate Symptom Score (IPSS) questionnaire and Common Terminology Criteria for Adverse Events (version 3.0). Median follow-up time for patients with at least 2 years of follow-up (n = 130) was 34.4 months (range, 24-56.9 months). Results: Mean IO urethra V{sub 150} was 0.018% {+-} 0.08%. Mean prostate D{sub 90} and V{sub 100} on day-30 computed tomography scan were 158.0 {+-} 27.0 Gy and 92.1% {+-} 7.2%, respectively. Mean IPSS peak was 9.5 {+-} 6.3 1 month after BT (mean difference from baseline IPSS, 5.3). No acute GI toxicity was observed in 86.8% of patients. The 3-year probability of Grade {>=}2 late GU toxicity-free survival was 77.4% {+-} 4.0%, with Grade 3 late GU toxicity encountered in only 3 patients. Three-year Grade 1 late GI toxicity-free survival was 86.1% {+-} 3.2%. No patient presented Grade {>=}2 late GI toxicity. Of patients with normal sexual status at baseline, 20.7% manifested Grade {>=}2 erectile dysfunction after BT. On multivariate analysis, elevated baseline IPSS (p = 0.016) and high-activity sources (median 0.61 mCi) (p = 0.033) predicted increased Grade {>=}2 late GU toxicity. Conclusions: Urethra-sparing IO BT results in low acute and late GU toxicity compared with the literature. High seed activity and elevated IPSS at baseline increased long-term GU toxicity.

  16. Comparison of Acute and Late Toxicities for Three Modern High-Dose Radiation Treatment Techniques for Localized Prostate Cancer

    SciTech Connect

    Mohammed, Nasiruddin; Kestin, Larry; Ghilezan, Mihai; Krauss, Daniel; Vicini, Frank; Brabbins, Donald; Gustafson, Gary; Ye Hong; Martinez, Alavaro

    2012-01-01

    Purpose: We compared acute and late genitourinary (GU) and gastrointestinal (GI) toxicities in prostate cancer patients treated with three different high-dose radiation techniques. Methods and Materials: A total of 1,903 patients with localized prostate cancer were treated with definitive RT at William Beaumont Hospital from 1992 to 2006: 22% with brachytherapy alone (BT), 55% with image-guided external beam (EB-IGRT), and 23% external beam with high-dose-rate brachytherapy boost (EBRT+HDR). Median dose with BT was 120 Gy for LDR and 38 Gy for HDR (9.5 Gy Multiplication-Sign 4). Median dose with EB-IGRT was 75.6 Gy (PTV) to prostate with or without seminal vesicles. For EBRT+HDR, the pelvis was treated to 46 Gy with an additional 19 Gy (9.5 Gy Multiplication-Sign 2) delivered via HDR. GI and GU toxicity was evaluated utilizing the NCI-CTC criteria (v.3.0). Median follow-up was 4.8 years. Results: The incidences of any acute {>=} Grade 2 GI or GU toxicities were 35%, 49%, and 55% for BT, EB-IGRT, and EBRT+HDR (p < 0.001). Any late GU toxicities {>=} Grade 2 were present in 22%, 21%, and 28% for BT, EB-IGRT, and EBRT+HDR (p = 0.01), respectively. Patients receiving EBRT+HDR had a higher incidence of urethral stricture and retention, whereas dysuria was most common in patients receiving BT. Any Grade {>=}2 late GI toxicities were 2%, 20%, and 9% for BT, EB-IGRT, and EBRT+HDR (p < 0.001). Differences were most pronounced for rectal bleeding, with 3-year rates of 0.9%, 20%, and 6% (p < 0.001) for BT, EB-IGRT, and EBRT+HDR respectively. Conclusions: Each of the three modern high-dose radiation techniques for localized prostate cancer offers a different toxicity profile. These data can help patients and physicians to make informed decisions regarding radiotherapy for prostate andenocarcinoma.

  17. The Gut Microbiota: Ecology and Function

    SciTech Connect

    Willing, B.P.; Jansson, J.K.

    2010-06-01

    The gastrointestinal (GI) tract is teeming with an extremely abundant and diverse microbial community. The members of this community have coevolved along with their hosts over millennia. Until recently, the gut ecosystem was viewed as black box with little knowledge of who or what was there or their specific functions. Over the past decade, however, this ecosystem has become one of fastest growing research areas of focus in microbial ecology and human and animal physiology. This increased interest is largely in response to studies tying microbes in the gut to important diseases afflicting modern society, including obesity, allergies, inflammatory bowel diseases, and diabetes. Although the importance of a resident community of microorganisms in health was first hypothesized by Pasteur over a century ago (Sears, 2005), the multiplicity of physiological changes induced by commensal bacteria has only recently been recognized (Hooper et al., 2001). The term 'ecological development' was recently coined to support the idea that development of the GI tract is a product of the genetics of the host and the host's interactions with resident microbes (Hooper, 2004). The search for new therapeutic targets and disease biomarkers has escalated the need to understand the identities and functions of the microorganisms inhabiting the gut. Recent studies have revealed new insights into the membership of the gut microbial community, interactions within that community, as well as mechanisms of interaction with the host. This chapter focuses on the microbial ecology of the gut, with an emphasis on information gleaned from recent molecular studies.

  18. The relationship between leaf area growth and biomass accumulation in Arabidopsis thaliana

    DOE PAGES [OSTI]

    Weraduwage, Sarathi M.; Chen, Jin; Anozie, Fransisca C.; Morales, Alejandro; Weise, Sean E.; Sharkey, Thomas D.

    2015-04-09

    Leaf area growth determines the light interception capacity of a crop and is often used as a surrogate for plant growth in high-throughput phenotyping systems. The relationship between leaf area growth and growth in terms of mass will depend on how carbon is partitioned among new leaf area, leaf mass, root mass, reproduction, and respiration. A model of leaf area growth in terms of photosynthetic rate and carbon partitioning to different plant organs was developed and tested with Arabidopsis thaliana L. Heynh. ecotype Columbia (Col-0) and a mutant line, gigantea-2 (gi-2), which develops very large rosettes. Data obtained from growthmore » analysis and gas exchange measurements was used to train a genetic programming algorithm to parameterize and test the above model. The relationship between leaf area and plant biomass was found to be non-linear and variable depending on carbon partitioning. The model output was sensitive to the rate of photosynthesis but more sensitive to the amount of carbon partitioned to growing thicker leaves. The large rosette size of gi-2 relative to that of Col-0 resulted from relatively small differences in partitioning to new leaf area vs. leaf thickness.« less

  19. The relationship between leaf area growth and biomass accumulation in Arabidopsis thaliana

    SciTech Connect

    Weraduwage, Sarathi M.; Chen, Jin; Anozie, Fransisca C.; Morales, Alejandro; Weise, Sean E.; Sharkey, Thomas D.

    2015-04-09

    Leaf area growth determines the light interception capacity of a crop and is often used as a surrogate for plant growth in high-throughput phenotyping systems. The relationship between leaf area growth and growth in terms of mass will depend on how carbon is partitioned among new leaf area, leaf mass, root mass, reproduction, and respiration. A model of leaf area growth in terms of photosynthetic rate and carbon partitioning to different plant organs was developed and tested with Arabidopsis thaliana L. Heynh. ecotype Columbia (Col-0) and a mutant line, gigantea-2 (gi-2), which develops very large rosettes. Data obtained from growth analysis and gas exchange measurements was used to train a genetic programming algorithm to parameterize and test the above model. The relationship between leaf area and plant biomass was found to be non-linear and variable depending on carbon partitioning. The model output was sensitive to the rate of photosynthesis but more sensitive to the amount of carbon partitioned to growing thicker leaves. The large rosette size of gi-2 relative to that of Col-0 resulted from relatively small differences in partitioning to new leaf area vs. leaf thickness.

  20. Microbial community proteomics for characterizing the range of metabolic functions and activities of human gut microbiota

    DOE PAGES [OSTI]

    Xiong, Weili; Abraham, Paul E.; Li, Zhou; Pan, Chongle; Robert L. Hettich

    2015-01-01

    We found that the human gastrointestinal (GI) tract is a complex, dynamic ecosystem that consists of a carefully tuned balance of human host and microbiota membership. The microbiome component is not insignificant, but rather provides important functions that are absolutely critical to many aspects of human health, including nutrient transformation and absorption, drug metabolism, pathogen defense, and immune system development. Microbial community proteomics (sometimes referred to as metaproteomics) provides a powerful approach to measure the range and details of human gut microbiota functions and metabolic activities, revealing information about microbiome development and stability especially with regard to human health vs.more » disease states. In most cases, both microbial and human proteins are extracted from fecal samples and then measured by the high performance MS-based proteomics technology. We review the field of human gut microbiome community proteomics, with a focus on the experimental and informatics considerations involved in characterizing systems that range from low complexity defined model gut microbiota in gnotobiotic mice, to the simple gut microbiota in the GI tract of newborn infants, and finally to the complex gut microbiota in adults. Moreover, the current state-of-the-art in experimental and bioinformatics capabilities for community proteomics enable a detailed measurement of the gut microbiota, yielding valuable insights into the broad functional profiles of even complex microbiota. Future developments are likely to expand into improved analysis throughput and coverage depth, as well as post-translational modification characterizations.« less

  1. SU-E-T-335: Transit Dosimetry for Verification of Dose Delivery Using Electronic Portal Imaging Device (EPID)

    SciTech Connect

    Baek, T; Chung, E; Lee, S; Yoon, M

    2014-06-01

    Purpose: To evaluate the effectiveness of transit dose, measured with an electronic portal imaging device (EPID), in verifying actual dose delivery to patients. Methods: Plans of 5 patients with lung cancer, who received IMRT treatment, were examined using homogeneous solid water phantom and inhomogeneous anthropomorphic phantom. To simulate error in patient positioning, the anthropomorphic phantom was displaced from 5 mm to 10 mm in the inferior to superior (IS), superior to inferior (SI), left to right (LR), and right to left (RL) directions. The transit dose distribution was measured with EPID and was compared to the planed dose using gamma index. Results: Although the average passing rate based on gamma index (GI) with a 3% dose and a 3 mm distance-to-dose agreement tolerance limit was 94.34 % for the transit dose with homogeneous phantom, it was reduced to 84.63 % for the transit dose with inhomogeneous anthropomorphic phantom. The Result also shows that the setup error of 5mm (10mm) in IS, SI, LR and SI direction can Result in the decrease in values of GI passing rates by 1.3% (3.0%), 2.2% (4.3%), 5.9% (10.9%), and 8.9% (16.3%), respectively. Conclusion: Our feasibility study suggests that the transit dose-based quality assurance may provide information regarding accuracy of dose delivery as well as patient positioning.

  2. Stable, concentrated solutions of high molecular weight polyaniline and articles therefrom

    DOEpatents

    Mattes, Benjamin R.; Wang, Hsing-Lin

    1999-11-09

    Stable, concentrated solutions of high molecular weight polyaniline. In order to process high quality fibers and other articles possessing good mechanical properties, it is known that solution concentrations of the chosen polymer should be in the range from 15-30% (w/w). Moreover, it is desirable to use the highest molecular weight consistent with the solubility properties of the polymer. However, such solutions are inherently unstable, forming gels before processing can be achieved. The present invention describes the addition gel inhibitors (GIs) to the polymer solution, thereby permitting high concentrations (between 15% and 30% (w/w)) of high molecular weight ((M.sub.w)>120,000, and (M.sub.n)>30,000) emeraldine base (EB) polyaniline to be dissolved. Secondary amines have been used for this purpose in concentrations which are small compared to those which might otherwise be used in a cosolvent role therefor. The resulting solutions are useful for generating excellent fibers, films, coatings and other objects, since the solutions are stable for significant time periods, and the GIs are present in too small concentrations to cause polymer deterioration. It is demonstrated that the GIs found to be useful do not act as cosolvents, and that gelation times of the solutions are directly proportional to the concentration of GI. In particular, there is a preferred concentration of GI, which if exceeded causes structural and electrical conductivity degradation of resulting articles. Heating of the solutions significantly improves solubility.

  3. Stable, concentrated solutions of high molecular weight polyaniline and articles therefrom

    DOEpatents

    Mattes, Benjamin R.; Wang, Hsing-Lin

    2000-01-01

    Stable, concentrated solutions of high molecular weight polyaniline. In order to process high quality fibers and other articles possessing good mechanical properties, it is known that solution concentrations of the chosen polymer should be in the range from 15-30% (w/w). Moreover, it is desirable to use the highest molecular weight consistent with the solubility properties of the polymer. However, such solutions are inherently unstable, forming gels before processing can be achieved. The present invention describes the addition gel inhibitors (GIs) to the polymer solution, thereby permitting high concentrations (>15% (w/w)) of high molecular weight ((M.sub.w)>120,000, and (M.sub.n)>30,000) emeraldine base (EB) polyaniline to be dissolved. Secondary amines have been used for this purpose in concentrations which are small compared to those which might otherwise be used in a cosolvent role therefor. The resulting solutions are useful for generating excellent fibers, films, coatings and other objects, since the solutions are stable for significant time periods, and the GIs are present in too small concentrations to cause polymer deterioration. It is demonstrated that the GIs found to be useful do not act as cosolvents, and that gelation times of the solutions are directly proportional to the concentration of GI. In particular, there is a preferred concentration of GI, which if exceeded causes structural and electrical conductivity degradation of resulting articles. Heating of the solutions significantly improves solubility.

  4. Method for preparing polyaniline fibers

    DOEpatents

    Mattes, Benjamin R.; Wang, Hsing-Lin

    2000-01-01

    Stable, concentrated solutions of high molecular weight polyaniline. In order to process high quality fibers and other articles possessing good mechanical properties, it is known that solution concentrations of the chosen polymer should be in the range from 15-30% (w/w). Moreover, it is desirable to use the highest molecular weight consistent with the solubility properties of the polymer. However, such solutions are inherently unstable, forming gels before processing can be achieved. The present invention describes the addition gel inhibitors (GIs) to the polymer solution, thereby permitting high concentrations (>15% (w/w)) of high molecular weight ((M.sub.w)>120,000, and (M.sub.n)>30,000) emeraldine base (EB) polyaniline to be dissolved. Secondary amines have been used for this purpose in concentrations which are small compared to those which might otherwise be used in a cosolvent role therefor. The resulting solutions are useful for generating excellent fibers, films, coatings and other objects, since the solutions are stable for significant time periods, and the GIs are present in too small concentrations to cause polymer deterioration. It is demonstrated that the GIs found to be useful do not act as cosolvents, and that gelation times of the solutions are directly proportional to the concentration of GI. In particular, there is a preferred concentration of GI, which if exceeded causes structural and electrical conductivity degradation of resulting articles. Heating of the solutions significantly improves solubility.

  5. Refueliing Infrastructure for Alternative Fuel Vehicles: Lessons Learned for Hydrogen

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    WEDNESDAY, APRIL 2 6:00-8:00 pm R Re eg gi is st tr ra at ti io on n a an nd d N Ne et tw wo or rk ki in ng g R Re ec ce ep pt ti io on n ( (l li ig gh ht t f fa ar re e) ) THURSDAY, APRIL 3 7:00 am R Re eg gi is st tr ra at ti io on n a an nd d C Co on nt ti in ne en nt ta al l B Br re ea ak kf fa as st t 8:00 am W We el lc co om me e 8:10 am P Pa an ne el l S Se es ss si io on n I I: : L Le es ss so on ns s f fr ro om m t th he e A AF FV V E Ex xp pe er ri ie en nc ce e Moderator: Dan

  6. Lisa Gerhardt! NERSC User Services Group! NUG Training!

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    February 23, 2015 Data Management at NERSC Where Do I Put My Data? --- 2 --- * Overview o f N ERSC fi le s ystems - Local v s. G lobal - Permanent v s. P urged - Personal v s. S hared * HPSS A rchive S ystem - What i s i t a nd h ow t o u se i t * Data S haring NERSC File Systems --- 3 --- The compute and storage systems 2015 Produc=on C lusters Carver, P DSF, J GI, MatComp, Planck /global/ scratch 4 PB /project 5 PB /home 250 TB 70 P B s tored, 2 40 P B capacity, 4 0 y ears o f community d ata

  7. Research News TEMPLATE

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Revealing Secrets Locked in the Ice page 3 the ENERGY lab NATIONAL ENERGY TECHNOLOGY LABORATORY From NETL's Office of Research & Development - October 2014, Issue 1 Researchnews Science & Engineering To Power Our Future 2 FE AT U RE ST O RY : R e v e a li n g S e c re ts L o c k e d in th e Ic e pa ge 3 Fr om NE TL 's O ffi ce of Re se ar ch & De ve lo pm en t - O ct ob er 20 14 , Iss ue 1 R e s e a r c h n e w s Sc ien ce & En gi ne er in g To Po we r Ou r Fu tu re Contents

  8. A=10C (1979AJ01)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    9AJ01) (See Energy Level Diagrams for 10C) GENERAL: See also (1974AJ01) and Table 10.22 [Table of Energy Levels] (in PDF or PS). Model calculations: (1974IR04, 1976IR1B). Special reactions (See also reaction 2 in (1974AJ01).): (1973BA81, 1974RI1A, 1975BA1Q, 1976BE1K, 1976BU16, 1977AR06). Pion reactions (See also reactions 3 and 9 here.): (1975GI1B, 1975RE01, 1977HO1B, 1977WA02, 1978AM01). Astrophysical questions: (1972PA1C, 1976VI1A, 1977SI1D). Other topics: (1974IR04, 1976IR1B, 1976VO1C).

  9. A=12Be (1975AJ02)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    75AJ02) (See the Isobar Diagram for 12Be) GENERAL: See also (1968AJ02) and Table 12.1 [Table of Energy Levels] (in PDF or PS). Special reactions: (1965GI10, 1969AR13, 1971AR02, 1972VO06, 1973KO1D). General review: (1974CE1A). Theoretical papers: (1971DO1F, 1972ST1C, 1973WI15, 1974IR04, 1974MA1E). Mass of 12Be: The Q-value of the 14C(18O, 20Ne)12Be reaction [-15.77 ± 0.05 MeV] (1974BA15) leads to an atomic mass excess of 25.05 ± 0.05 MeV; that for the 7Li(7Li, 2p)12Be reaction [Q = -9.71 ±

  10. A=12Be (1990AJ01)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    90AJ01) (See Energy Level Diagrams for 12Be) GENERAL: See also (1985AJ01) and Table 12.1 [Table of Energy Levels] (in PDF or PS) here. General theoretical papers: (1984FR13, 1985AN28, 1985BA51, 1985WI1B, 1986WI04, 1987BL18, 1987GI1C, 1987SA15, 1987YA16, 1988RU01, SU88C, 1989BE03). Hypernuclei: (1984IW1B, 1984YA04, 1985BE31, 1985GA1C, 1985IK1A, 1985WA1N, 1985YA01, 1985YA07, 1986BA1W, 1986BI1G, 1986DO1B, 1986GA14, 1986GA33, 1986GA1H, 1986HA26, 1986MA1J, 1986ME1F, 1986MI1N, 1986PO1H, 1986YA1T,

  11. A=12C (1975AJ02)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    75AJ02) (See Energy Level Diagrams for 12C) GENERAL: See also (1968AJ02) and Table 12.8 [Table of Energy Levels] (in PDF or PS). Shell model: (1967SV1A, 1968BA1L, 1968DR1B, 1968FA1B, 1968FU1B, 1968GO01, 1968GU1C, 1968HA11, 1968RO1G, 1969GU1E, 1969GU03, 1969IK1A, 1969LA26, 1969MO1F, 1969SA1A, 1969SV1A, 1969WA06, 1969WO05, 1970AR21, 1970BE26, 1970BO33, 1970BO1J, 1970CO1H, 1970DE1F, 1970DO1A, 1970EI06, 1970GI11, 1970GU11, 1970KH01, 1970KO04, 1970KR1D, 1970LO1C, 1970RE1G, 1970RU1A, 1970RY1A,

  12. A=12C (1980AJ01)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    0AJ01) (See Energy Level Diagrams for 12C) GENERAL: See also (1975AJ02) and Table 12.7 [Table of Energy Levels] (in PDF or PS). Shell model: (1974BO1P, 1975BI05, 1975BO27, 1975FR06, 1975GI1C, 1975MU13, 1975WA30, 1976BA24, 1977CA02, 1977CA08, 1977GR02, 1977JA14, 1978FU13, 1978MU04, 1978SV01, 1979LO1F). Collective and deformed models: (1974BO1P, 1975BO27, 1975KI21, 1975LE14, 1975MC15, 1975SO07, 1976GL1C, 1976PA25, 1977CA08, 1977TH03, 1977UE01, 1977VI03, 1979MA1J). Cluster and alpha particle

  13. A=12C (1985AJ01)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    5AJ01) (See Energy Level Diagrams for 12C) GENERAL: See also (1980AJ01) and Table 12.6 [Table of Energy Levels] (in PDF or PS). Shell model: (1977ME05, 1978RA1B, 1979HA59, 1979IN05, 1980CA12, 1980GI05, 1980HA35, 1980OH07, 1981AM08, 1981BO1Y, 1981DE2G, 1981LU1B, 1981RA06, 1982AR03, 1982BA52, 1982BR08, 1983VA31, 1984DE04, 1984VA06). Deformed models: (1979UE03, 1980BA1T, 1980BA44, 1980CA12, 1980FU1H, 1981DE2G, 1981RA06, 1981SE03, 1982AS03, 1982BR08, 1982KU1K, 1982SA1U, 1983LO04, 1983SA12,

  14. A=12N (1985AJ01)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    5AJ01) (See Energy Level Diagrams for 12N) GENERAL: See also (1980AJ01) and Table 12.22 [Table of Energy Levels] (in PDF or PS). Model calculations:(1980OK01). Muon and neutrino capture and reactions:(1979MA1U, 1982MI05). Pion capture and reactions (See also reactions 2, 4 and 5.):(1979BU1C, 1979NA1J, 1979RA1G, 1979SI16, 1980KE13, 1980KL03, 1980NA11, 1980RA05, 1980SI07, 1980TR1A, 1981DU1H, 1981SI09, 1981RA16, 1982BE1D, 1982RA28, 1982SC1L, 1983DE2G, 1983GI08). Hypernuclei:(1979BU1C, 1981WA1J,

  15. A=13N (1986AJ01)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    6AJ01) (See Energy Level Diagrams for 13N) GENERAL: See also (1981AJ01) and Table 13.14 [Table of Energy Levels] (in PDF or PS). Nuclear models: (1983SH38). Special states: (1981KO1Q, 1983AU1B, 1983WI15, 1984RO05). Electromagnetic transitions:(1980BA54, 1980RI06, 1981KO1Q, 1983AD1B, 1984MA2J). Astrophysical questions: (1980BA1P, 1983LI01, 1985GI1C). Applied work: (1982BO1N, 1982HA1V, 1982HI1H, 1982MA1T, 1982PI1H, 1982YA1C, 1983HA1W, 1983KO1Q, 1984HI1D, 1984MO1Q, 1984MO1R, 1984NI1C). Complex

  16. A=14Be (1986AJ01)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    86AJ01) (See the Isobar Diagram for 14Be) 14Be has been observed in the 4.8 GeV proton bombardment of uranium [see (1976AJ04)], in the bombardment of 232Th by 145 MeV 15N ions (1982OG02; forward differential cross section is 4 × 10-5 mb/sr) and in the 14C(π-, π+)14Be reaction (1984GI09; Eπ- = 164 MeV, θ = 5° It has not been observed in the 48Ca(14C, 14Be)48Ti reaction (E(14C) = 87.4 MeV, θ = 4° - 8° (1981NA1H). A group in the (π-, π+) reaction is observed at Q = -37.08 ± 0.13 MeV

  17. A=14N (1981AJ01)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    81AJ01) (See Energy Level Diagrams for 14N) GENERAL: See also (1976AJ04) and Table 14.10 [Table of Energy Levels] (in PDF or PS). Model calculations: (1976CO1R, 1978FU13). Special states: (1977GO1H, 1977RI08, 1979KI10). Electromagnetic transitions: (1977DO06, 1977KO1N, 1977YO1D, 1978FU13, 1978KI08). Giant resonances: (1979DO17, 1979KI11). Astrophysical questions: (1976AU1B, 1976BO1M, 1976DI1F, 1976DW1A, 1976EP1A, 1976FI1E, 1976GI1C, 1976ME1H, 1976NO1C, 1976OS1E, 1976QU1A, 1976RO1J, 1976SI1D,

  18. A=15O (1986AJ01)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    6AJ01) (See Energy Level Diagrams for 15O) GENERAL: See also (1981AJ01) and Table 15.17 [Table of Energy Levels] (in PDF or PS) here. Nuclear models:(1982WA1Q, 1982YA1D, 1983SH38). Special states:(1979GO27, 1980GO1Q, 1980HI1C, 1984ST1E). Electromagentic transitions:(1980KO1L, 1980MI1G, 1980RI06, 1982AW02, 1983TO08, 1984CA02). Astrophysical questions:(1980BA1P, 1981WA1Q, 1983LI01, 1985GI1C). Complex reactions involving 15O:(1981HU1D, 1981SC1P, 1983DE26, 1983FR1A, 1983JA05, 1983OL1A, 1983WI1A,

  19. A=18F (1972AJ02)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    2AJ02) (See Energy Level Diagrams for 18F) GENERAL: See also (1959AJ76) and Table 18.10 [Table of Energy Levels] (in PDF or PS). Shell model: (1957WI1E, 1959BR1E, 1960TA1C, 1961TR1B, 1962TA1D, 1964FE02, 1964IN03, 1964PA1D, 1964YO1B, 1965BA1J, 1965DE1H, 1965GI1B, 1966BA2E, 1966BA2C, 1966HU09, 1966IN01, 1966KU05, 1966RI1F, 1967EN01, 1967EV1C, 1967FE01, 1967FL01, 1967HO11, 1967IN03, 1967KU09, 1967KU13, 1967LY02, 1967MO1J, 1967PA1K, 1967PI1B, 1967VI1B, 1967WO1C, 1968AR02, 1968BE1T, 1968BH1B,

  20. A=5Li (1984AJ01)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    84AJ01) (See Energy Level Diagrams for 5Li) GENERAL: See also (1979AJ01) and Table 5.3 [Table of Energy Levels] (in PDF or PS) here. Model calculations:(1978RE1A, 1979MA1J, 1980HA1M, 1981BE10, 1982FI13). Special states:(1981BE10, 1981KU1H, 1982EM1A, 1982FI13, 1982FR1D). Complex reactions involving 5Li:(1979BR02, 1979RU1B). Reactions involving pions:(1978BR1V, 1979SA1W, 1983AS02). Reactions involving antiprotons:(1981YA1B). Hypernuclei:(1980IW1A, 1981KO1V, 1981KU1H, 1983GI1C). Other

  1. A=7He (1988AJ01)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    8AJ01) (See the Isobar Diagram for 7He) GENERAL: See also (1984AJ01) and Table 7.1 [Table of Energy Levels] (in PDF or PS). Hypernuclei: (1982KA1D, 1983FE07, 1984AS1D, 1985KO1G, 1986DA1B, 1986DO01, 1986ME1F). Other topics: (1983ANZQ, 1984FR13, 1984VA06, 1986GI10, 1986SH1L, 1987BO40, 1987GOZN, 1987PE1C). Mass of 7He: The atomic mass excess of 7He is 26.11 ± 0.03 MeV: 7He is then unbound with respect to decay into 6He + n by 0.44 MeV: see (1984AJ01). The ground state is calculated to have Jπ =

  2. A=9He (1974AJ01)

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    4AJ01) (Not illustrated) 9He is predicted to be particle unstable: its calculated mass excess > 40.17 MeV (1970WA1G, 1972WA07), = 43.54 MeV (1972TH13). Particle instability with respect to 8He + n, 7He + 2n and 6He + 3n implies atomic mass excesses greater than 39.7, 42.25 and 41.812 MeV, respectively. See also (1968CE1A). 9He has not been observed in a pion experiment [9Be(π-, π+)9He] (1965GI10) nor in the spontaneous fission of 252Cf (1967CO1K

  3. NUG2013UserSurvey.pptx

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    2 NERSC User Survey Results --- 1 --- NUG 2 013 2 Response Profile 481 r espondents ( + 7 1 J GI o nly) * 6 7.6% " big u ser" r esponse r ate * 3 6.2% " medium u ser" r esponse r ate * 1 1.8% o verall r esponse r ate BER HEP Respondants b y R ole Pis --- 2 5.4% Proxies --- 15.2% Users --- 59.5% Respondants b y O ffice ASCR --- 7 .9% BER --- 2 0.6% BES --- 34.5% FES --- 1 3.5% HEP --- 1 4.6% NP --- 8 .3% BES FES NP ASCR HEP BER PIs Users Proxies 2012 Survey Question &

  4. Cryogenic expansion machine

    DOEpatents

    Pallaver, Carl B.; Morgan, Michael W.

    1978-01-01

    A cryogenic expansion engine includes intake and exhaust poppet valves each controlled by a cam having adjustable dwell, the valve seats for the valves being threaded inserts in the valve block. Each cam includes a cam base and a ring-shaped cam insert disposed at an exterior corner of the cam base, the cam base and cam insert being generally circular but including an enlarged cam dwell, the circumferential configuration of the cam base and cam dwell being identical, the cam insert being rotatable with respect to the cam base. GI CONTRACTUAL ORIGIN OF THE INVENTION The invention described herein was made in the course of, or under, a contract with the UNITED STATES ENERGY RESEARCH AND DEVELOPMENT ADMINISTRATION.

  5. Method of fabricating conducting oxide-silicon solar cells utilizing electron beam sublimation and deposition of the oxide

    DOEpatents

    Feng, Tom; Ghosh, Amal K.

    1979-01-01

    In preparing tin oxide and indium tin oxide-silicon heterojunction solar cells by electron beam sublimation of the oxide and subsequent deposition thereof on the silicon, the engineering efficiency of the resultant cell is enhanced by depositing the oxide at a predetermined favorable angle of incidence. Typically the angle of incidence is between 40.degree. and 70.degree. and preferably between 55.degree. and 65.degree. when the oxide is tin oxide and between 40.degree. and 70.degree. when the oxide deposited is indium tin oxide. gi The Government of the United States of America has rights in this invention pursuant to Department of Energy Contract No. EY-76-C-03-1283.

  6. Optimization of leaf margins for lung stereotactic body radiotherapy using a flattening filter-free beam

    SciTech Connect

    Wakai, Nobuhide; Sumida, Iori; Otani, Yuki; Suzuki, Osamu; Seo, Yuji; Isohashi, Fumiaki; Yoshioka, Yasuo; Ogawa, Kazuhiko; Hasegawa, Masatoshi

    2015-05-15

    Purpose: The authors sought to determine the optimal collimator leaf margins which minimize normal tissue dose while achieving high conformity and to evaluate differences between the use of a flattening filter-free (FFF) beam and a flattening-filtered (FF) beam. Methods: Sixteen lung cancer patients scheduled for stereotactic body radiotherapy underwent treatment planning for a 7 MV FFF and a 6 MV FF beams to the planning target volume (PTV) with a range of leaf margins (?3 to 3 mm). Forty grays per four fractions were prescribed as a PTV D95. For PTV, the heterogeneity index (HI), conformity index, modified gradient index (GI), defined as the 50% isodose volume divided by target volume, maximum dose (Dmax), and mean dose (Dmean) were calculated. Mean lung dose (MLD), V20 Gy, and V5 Gy for the lung (defined as the volumes of lung receiving at least 20 and 5 Gy), mean heart dose, and Dmax to the spinal cord were measured as doses to organs at risk (OARs). Paired t-tests were used for statistical analysis. Results: HI was inversely related to changes in leaf margin. Conformity index and modified GI initially decreased as leaf margin width increased. After reaching a minimum, the two values then increased as leaf margin increased (V shape). The optimal leaf margins for conformity index and modified GI were ?1.1 0.3 mm (mean 1 SD) and ?0.2 0.9 mm, respectively, for 7 MV FFF compared to ?1.0 0.4 and ?0.3 0.9 mm, respectively, for 6 MV FF. Dmax and Dmean for 7 MV FFF were higher than those for 6 MV FF by 3.6% and 1.7%, respectively. There was a positive correlation between the ratios of HI, Dmax, and Dmean for 7 MV FFF to those for 6 MV FF and PTV size (R = 0.767, 0.809, and 0.643, respectively). The differences in MLD, V20 Gy, and V5 Gy for lung between FFF and FF beams were negligible. The optimal leaf margins for MLD, V20 Gy, and V5 Gy for lung were ?0.9 0.6, ?1.1 0.8, and ?2.1 1.2 mm, respectively, for 7 MV FFF compared to ?0.9 0.6, ?1.1 0

  7. C:\Forms\HQ F 1410.4.cdr

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    F-1410.4 (11-79) 2 . SENT F ROM ( NAME OF OFFI CE) 5. RECEI VED BY ( NAME OR OFFI CE) Thank you for your cooperation. Please return promptly. SECTI ON A ( O P T I O N A L F O L D ) ( O P T I O N A L F O L D ) 3 . DAT E 6 . DAT E ORI GI NAT I NG OF F I CE USE 8 . DAT E DI SPAT CHED FOR RETURN 4 . T I ME 7 . T I ME T I ME RETURNED - - DAT E 9 . T I ME A M A M A M A M P M P M P M P M 1 . CONTROL NO. TO: RETURN TO: ORIGINATOR FILL IN: ORIGINATOR FILL IN: RECIPIENT FILL IN: U.S. DEPARTMENT OF ENERGY

  8. In situ quantification of genomic instability in breast cancer progression

    SciTech Connect

    Ortiz de Solorzano, Carlos; Chin, Koei; Gray, Joe W.; Lockett, Stephen J.

    2003-05-15

    Genomic instability is a hallmark of breast and other solid cancers. Presumably caused by critical telomere reduction, GI is responsible for providing the genetic diversity required in the multi-step progression of the disease. We have used multicolor fluorescence in situ hybridization and 3D image analysis to quantify genomic instability cell-by-cell in thick, intact tissue sections of normal breast epithelium, preneoplastic lesions (usual ductal hyperplasia), ductal carcinona is situ or invasive carcinoma of the breast. Our in situ-cell by cell-analysis of genomic instability shows an important increase of genomic instability in the transition from hyperplasia to in situ carcinoma, followed by a reduction of instability in invasive carcinoma. This pattern suggests that the transition from hyperplasia to in situ carcinoma corresponds to telomere crisis and invasive carcinoma is a consequence of telomerase reactivation afertelomere crisis.

  9. Jason Hick! Storage Systems Group NERSC User Group Storage Update

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    NERSC User Group Storage Update Feb 2 6, 2 014 The compute and storage systems 2014 Sponsored C ompute S ystems Carver, P DSF, J GI, K BASE, H EP 8 x F DR I B /global/ scratch 4 PB /project 5 PB /home 250 TB 45 P B s tored, 2 40 P B capacity, 4 0 y ears o f community d ata HPSS 48 GB/s 2.2 P B L ocal Scratch 70 GB/s 6.4 P B L ocal Scratch 140 GB/s 80 GB/s Ethernet & I B F abric Science F riendly S ecurity ProducKon M onitoring Power E fficiency WAN 2 x 10 Gb 1 x 100 Gb Science D ata N etwork

  10. Jason Hick! Storage Systems Group! NERSC User Group Meeting!

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Group! ! NERSC User Group Meeting! February 6, 2014 Storage Systems: 2014 and beyond The compute and storage systems 2013 Produc(on C lusters Carver, P DSF, J GI,KBASE,HEP 1 4x Q DR Global Scratch 3.6 PB 5 x S FA12KE /project 5 PB DDN9900 & NexSAN /home 250 TB NetApp 5 460 50 P B s tored, 2 40 PB c apacity, 3 5 years o f community d ata HPSS 16 x Q DR I B 2.2 P B L ocal Scratch 70 GB/s 6.4 P B L ocal Scratch 140 GB/s 16 x F DR I B Ethernet & I B F abric Science F riendly S ecurity

  11. Jay Srinivasan! Group Lead, Computational Systems!

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Group Lead, Computational Systems! NUG - Feb 2015 Computational Systems Update NERSC - 2014 --- 2 --- Sponsored C ompute S ystems Carver, P DSF, J GI, K BASE, H EP 8 x F DR I B /global/ scratch 4 PB /project 5 PB /home 250 TB 45 P B s tored, 2 40 P B capacity, 4 0 y ears o f community d ata HPSS 48 GB/s 2.2 P B L ocal Scratch 70 GB/s 6.4 P B L ocal Scratch 140 GB/s 80 GB/s 2 x 10 Gb 1 x 100 Gb Science D ata N etwork Vis & A naly?cs, D ata T ransfer N odes, Adv. A rch., S cience G ateways 80

  12. Health Impacts from Acute Radiation Exposure

    SciTech Connect

    Strom, Daniel J.

    2003-09-30

    Absorbed doses above1-2 Gy (100-200 rads) received over a period of a day or less lead to one or another of the acute radiation syndromes. These are the hematopoietic syndrome, the gastrointestinal (GI) syndrome, the cerebrovascular (CV) syndrome, the pulmonary syndrome, or the cutaneous syndrome. The dose that will kill about 50% of the exposed people within 60 days with minimal medical care, LD50-60, is around 4.5 Gy (450 rads) of low-LET radiation measured free in air. The GI syndrome may not be fatal with supportive medical care and growth factors below about 10 Gy (1000 rads), but above this is likely to be fatal. Pulmonary and cutaneous syndromes may or may not be fatal, depending on many factors. The CV syndrome is invariably fatal. Lower acute doses, or protracted doses delivered over days or weeks, may lead to many other health outcomes than death. These include loss of pregnancy, cataract, impaired fertility or temporary or permanent sterility, hair loss, skin ulceration, local tissue necrosis, developmental abnormalities including mental and growth retardation in persons irradiated as children or fetuses, radiation dermatitis, and other symptoms listed in Table 2 on page 12. Children of parents irradiated prior to conception may experience heritable ill-health, that is, genetic changes from their parents. These effects are less strongly expressed than previously thought. Populations irradiated to high doses at high dose rates have increased risk of cancer incidence and mortality, taken as about 10-20% incidence and perhaps 5-10% mortality per sievert of effective dose of any radiation or per gray of whole-body absorbed dose low-LET radiation. Cancer risks for non-uniform irradiation will be less.

  13. Experimental single-strain mobilomics reveals events that shape pathogen emergence

    DOE PAGES [OSTI]

    Schoeniger, Joseph S.; Hudson, Corey M.; Bent, Zachary W.; Sinha, Anupama; Williams, Kelly P.

    2016-07-04

    Virulence and resistance genes carried on mobile DNAs such as genomic islands (GIs) and plasmids promote bacterial pathogen emergence. An early step in the mobilization of GIs is their excision, which produces both a circular form of the GI and a deletion site in the chromosome; circular forms have also been described for some bacterial insertion sequences (ISs). We demonstrate that the recombinant sequence produced at the junction of such circles, and their corresponding deletion sites, can be detected sensitively in high throughput sequencing data, using new computational methods that enable empirical discovery of new mobile DNAs. Applied to themore » rich mobilome of a single strain (Kpn2146) of the emerging multidrug-resistant pathogen Klebsiella pneumoniae, our approach detected circular junctions for six GIs and seven IS types (several of the latter not previously known to circularize). Our methods further revealed differential biology of multiple mobile DNAs, imprecision of integrases and transposases, and differential activity among identical IS copies for IS26, ISKpn18 and ISKpn21. Exonuclease was used to enrich for circular dsDNA molecules, and internal calibration with the native Kpn2146 plasmids showed that not all molecules bearing GI and IS circular junctions were circular dsDNAs. Transposition events were also detected, revealing replicon preference (ISKpn18 preferring a conjugative IncA/C2 plasmid), local action (IS26), regional preferences, selection (against capsule synthesis), and left-right IS end swapping. Efficient discovery and global characterization of numerous mobile elements per experiment will allow detailed accounting of bacterial evolution, explaining the new gene combinations that arise in emerging pathogens.« less

  14. MIGRATION OF GAS GIANT PLANETS IN GRAVITATIONALLY UNSTABLE DISKS

    SciTech Connect

    Michael, Scott; Durisen, Richard H.; Boley, Aaron C. E-mail: durisen@astro.indiana.edu

    2011-08-20

    Characterization of migration in gravitationally unstable disks is necessary to understand the fate of protoplanets formed by disk instability. As part of a larger study, we are using a three-dimensional radiative hydrodynamics code to investigate how an embedded gas giant planet interacts with a gas disk that undergoes gravitational instabilities (GIs). This Letter presents results from simulations with a Jupiter-mass planet placed in orbit at 25 AU within a 0.14 M{sub sun} disk. The disk spans 5-40 AU around a 1 M{sub sun} star and is initially marginally unstable. In one simulation, the planet is inserted prior to the eruption of GIs; in another, it is inserted only after the disk has settled into a quasi-steady GI-active state, where heating by GIs roughly balances radiative cooling. When the planet is present from the beginning, its own wake stimulates growth of a particular global mode with which it strongly interacts, and the planet plunges inward 6 AU in about 10{sup 3} years. In both cases with embedded planets, there are times when the planet's radial motion is slow and varies in direction. At other times, when the planet appears to be interacting with strong spiral modes, migration both inward and outward can be relatively rapid, covering several AUs over hundreds of years. Migration in both cases appears to stall near the inner Lindblad resonance of a dominant low-order mode. Planet orbit eccentricities fluctuate rapidly between about 0.02 and 0.1 throughout the GI-active phases of the simulations.

  15. The SDSS view of the Palomar-Green bright quasar survey

    SciTech Connect

    Jester, Sebastian; Schneider, Donald P.; Richards, Gordon T.; Green, Richard F.; Schmidt, Maarten; Hall, Patrick B.; Strauss, Michael A.; Vanden Berk, Daniel E.; Stoughton, Chris; Gunn, James E.; Brinkmann, Jon; Kent, Stephen M.; Smith, J.Allyn; Tucker, Douglas, L.; Yanny, Brian; /Fermilab /Penn State U., Astron. Astrophys. /Princeton U. Observ. /Kitt Peak Observ. /Caltech /Chicago U., Astron. Astrophys. Ctr. /York U., Canada /Apache Point Observ. /Wyoming U. /Los Alamos

    2005-02-01

    The author investigates the extent to which the Palomar-Green (PG) Bright Quasar Survey (BQS) is complete and representative of the general quasar population by comparing with imaging and spectroscopy from the Sloan Digital Sky Survey. A comparison of SDSS and PG photometry of both stars and quasars reveals the need to apply a color and magnitude recalibration to the PG data. Using the SDSS photometric catalog, they define the PG's parent sample of objects that are not main-sequence stars and simulate the selection of objects from this parent sample using the PG photometric criteria and errors. This simulation shows that the effective U-B cut in the PG survey is U-B < -0.71, implying a color-related incompleteness. As the color distribution of bright quasars peaks near U-B = -0.7 and the 2-{sigma} error in U-B is comparable to the full width of the color distribution of quasars, the color incompleteness of the BQS is approximately 50% and essentially random with respect to U-B color for z < 0.5. There is however, a bias against bright quasars at 0.5 < z < 1, which is induced by the color-redshift relation of quasars (although quasars at z > 0.5 are inherently rare in bright surveys in any case). They find no evidence for any other systematic incompleteness when comparing the distributions in color, redshift, and FIRST radio properties of the BQS and a BQS-like subsample of the SDSS quasar sample. However, the application of a bright magnitude limit biases the BQS toward the inclusion of objects which are blue in g-i, in particular compared to the full range of g-i colors found among the i-band limited SDSS quasars, and even at i-band magnitudes comparable to those of the BQS objects.

  16. Acute Toxicity After Image-Guided Intensity Modulated Radiation Therapy Compared to 3D Conformal Radiation Therapy in Prostate Cancer Patients

    SciTech Connect

    Wortel, Ruud C.; Incrocci, Luca; Pos, Floris J.; Lebesque, Joos V.; Witte, Marnix G.; Heide, Uulke A. van der; Herk, Marcel van; Heemsbergen, Wilma D.

    2015-03-15

    Purpose: Image-guided intensity modulated radiation therapy (IG-IMRT) allows significant dose reductions to organs at risk in prostate cancer patients. However, clinical data identifying the benefits of IG-IMRT in daily practice are scarce. The purpose of this study was to compare dose distributions to organs at risk and acute gastrointestinal (GI) and genitourinary (GU) toxicity levels of patients treated to 78 Gy with either IG-IMRT or 3D-CRT. Methods and Materials: Patients treated with 3D-CRT (n=215) and IG-IMRT (n=260) receiving 78 Gy in 39 fractions within 2 randomized trials were selected. Dose surface histograms of anorectum, anal canal, and bladder were calculated. Identical toxicity questionnaires were distributed at baseline, prior to fraction 20 and 30 and at 90 days after treatment. Radiation Therapy Oncology Group (RTOG) grade ≥1, ≥2, and ≥3 endpoints were derived directly from questionnaires. Univariate and multivariate binary logistic regression analyses were applied. Results: The median volumes receiving 5 to 75 Gy were significantly lower (all P<.001) with IG-IMRT for anorectum, anal canal, and bladder. The mean dose to the anorectum was 34.4 Gy versus 47.3 Gy (P<.001), 23.6 Gy versus 44.6 Gy for the anal canal (P<.001), and 33.1 Gy versus 43.2 Gy for the bladder (P<.001). Significantly lower grade ≥2 toxicity was observed for proctitis, stool frequency ≥6/day, and urinary frequency ≥12/day. IG-IMRT resulted in significantly lower overall RTOG grade ≥2 GI toxicity (29% vs 49%, respectively, P=.002) and overall GU grade ≥2 toxicity (38% vs 48%, respectively, P=.009). Conclusions: A clinically meaningful reduction in dose to organs at risk and acute toxicity levels was observed in IG-IMRT patients, as a result of improved technique and tighter margins. Therefore reduced late toxicity levels can be expected as well; additional research is needed to quantify such reductions.

  17. Long-Term Efficacy and Toxicity of Low-Dose-Rate {sup 125}I Prostate Brachytherapy as Monotherapy in Low-, Intermediate-, and High-Risk Prostate Cancer

    SciTech Connect

    Kittel, Jeffrey A.; Reddy, Chandana A.; Smith, Kristin L.; Stephans, Kevin L.; Tendulkar, Rahul D.; Ulchaker, James; Angermeier, Kenneth; Campbell, Steven; Stephenson, Andrew; Klein, Eric A.; Wilkinson, D. Allan; Ciezki, Jay P.

    2015-07-15

    Purpose/Objectives: To report long-term efficacy and toxicity for a single-institution cohort of patients treated with low-dose-rate prostate brachytherapy permanent implant (PI) monotherapy. Methods and Materials: From 1996 to 2007, 1989 patients with low-risk (61.3%), intermediate-risk (29.8%), high-intermediate-risk (4.5%), and high-risk prostate cancer (4.4%) were treated with PI and followed up prospectively in a registry. All patients were treated with {sup 125}I monotherapy to 144 Gy. Late toxicity was coded retrospectively according to a modified Common Terminology Criteria for Adverse Events 4.0 scale. The rates of biochemical relapse-free survival (bRFS), distant metastasis-free survival (DMFS), overall survival (OS), and prostate cancer–specific mortality (PCSM) were calculated. We identified factors associated with late grade ≥3 genitourinary (GU) and gastrointestinal (GI) toxicity, bRFS, DMFS, OS, PCSM, and incontinence. Results: The median age of the patients was 67 years, and the median overall and prostate-specific antigen follow-up times were 6.8 years and 5.8 years, respectively. The overall 5-year rates for bRFS, DMFS, OS, and PCSM were 91.9%, 97.8%, 93.7%, and 0.71%, respectively. The 10-year rates were 81.5%, 91.5%, 76.1%, and 2.5%, respectively. The overall rates of late grade ≥3 GU and GI toxicity were 7.6% and 0.8%, respectively. On multivariable analysis, age and prostate length were significantly associated with increased risk of late grade ≥3 GU toxicity. The risk of incontinence was highly correlated with both pre-PI and post-PI transurethral resection of the prostate. Conclusions: Prostate brachytherapy as monotherapy is an effective treatment for low-risk and low-intermediate-risk prostate cancer and appears promising as a treatment for high-intermediate-risk and high-risk prostate cancer. Significant long-term toxicities are rare when brachytherapy is performed as monotherapy.

  18. SU-E-T-548: How To Decrease Spine Dose In Patients Who Underwent Sterotactic Spine Radiosurgery?

    SciTech Connect

    Acar, H; Altinok, A; Kucukmorkoc, E; Kucuk, N; Caglar, H

    2014-06-01

    Purpose: Stereotactic radiosurgery for spine metastases involves irradiation using a single high dose fraction. The purpose of this study was to dosimetrically compare stereotactic spine radiosurgery(SRS) plans using a recently new volumetric modulated arc therapy(VMAT) technique against fix-field intensity-modulated radiotherapy(IMRT). Plans were evaluated for target conformity and spinal cord sparing. Methods: Fifteen previously treated patients were replanned using the Eclipse 10.1 TPS AAA calculation algorithm. IMRT plans with 7 fields were generated. The arc plans used 2 full arc configurations. Arc and IMRT plans were normalized and prescribed to deliver 16.0 Gy in a single fraction to 90% of the planning target volume(PTV). PTVs consisted of the vertebral body expanded by 3mm, excluding the PRV-cord, where the cord was expanded by 2mm.RTOG 0631 recommendations were applied for treatment planning. Partial spinal cord volume was defined as 5mm above and below the radiosurgery target volume. Plans were compared for conformity and gradient index as well as spinal cord sparing. Results: The conformity index values of fifteen patients for two different treatment planning techniques were shown in table 1. Conformity index values for 2 full arc planning (average CI=0.84) were higher than that of IMRT planning (average CI=0.79). The gradient index values of fifteen patients for two different treatment planning techniques were shown in table 2. Gradient index values for 2 full arc planning (average GI=3.58) were higher than that of IMRT planning (average GI=2.82).The spinal cord doses of fifteen patients for two different treatment planning techniques were shown in table 3. D0.35cc, D0.03cc and partial spinal cord D10% values in 2 full arc plannings (average D0.35cc=819.3cGy, D0.03cc=965.4cGy, 10%partial spinal=718.1cGy) were lower than IMRT plannings (average D0.35cc=877.4cGy, D0.03c=1071.4cGy, 10%partial spinal=805.1cGy). Conclusions: The two arc VMAT technique is

  19. THE SLUGGS SURVEY: NGC 3115, A CRITICAL TEST CASE FOR METALLICITY BIMODALITY IN GLOBULAR CLUSTER SYSTEMS

    SciTech Connect

    Brodie, Jean P.; Conroy, Charlie; Arnold, Jacob A.; Romanowsky, Aaron J.; Usher, Christopher; Forbes, Duncan A.; Strader, Jay

    2012-11-10

    Due to its proximity (9 Mpc) and the strongly bimodal color distribution of its spectroscopically well-sampled globular cluster (GC) system, the early-type galaxy NGC 3115 provides one of the best available tests of whether the color bimodality widely observed in GC systems generally reflects a true metallicity bimodality. Color bimodality has alternatively been attributed to a strongly nonlinear color-metallicity relation reflecting the influence of hot horizontal-branch stars. Here, we couple Subaru Suprime-Cam gi photometry with Keck/DEIMOS spectroscopy to accurately measure GC colors and a CaT index that measures the Ca II triplet. We find the NGC 3115 GC system to be unambiguously bimodal in both color and the CaT index. Using simple stellar population models, we show that the CaT index is essentially unaffected by variations in horizontal-branch morphology over the range of metallicities relevant to GC systems (and is thus a robust indicator of metallicity) and confirm bimodality in the metallicity distribution. We assess the existing evidence for and against multiple metallicity subpopulations in early- and late-type galaxies and conclude that metallicity bi/multimodality is common. We briefly discuss how this fundamental characteristic links directly to the star formation and assembly histories of galaxies.

  20. Effect of granular porous media on the composting of swine manure

    SciTech Connect

    Kim, Ku-Yong; Kim, Hyun-Woo; Han, Sun-Kee; Hwang, Eung-Ju; Lee, Chae-Young; Shin, Hang-Sik

    2008-11-15

    This study investigated the feasibility of a bulking agent of granular porous media (GPM) for the composting of swine manure. Two lab-scale composting reactors were operated to evaluate the general performances and maturity parameters using GPM made of wastes from the Portland cement manufacturing processes as an alternative bulking agent. The overall volatile solid (VS) removal was 38.5% (dry basis). During the experiments, moisture content ranged between 41% and 53%, ensuring feasibility of microbial activity in composting. Cured compost showed proper maturity and low phytotoxicity, despite the slight decreases of CO{sub 2} production and VS removal at the second batch operation. Various physico-chemical parameters of the cured compost met the regulatory standards reported elsewhere. The pH, carbon-to-nitrogen ratio, ammonia nitrogen and soluble organic carbon (SOC) of the cured compost were significantly correlated to the germination index (GI) using the seeds of Chinese cabbage and lettuce, indicating the progressive biodegradation of phytotoxins as well as organic matter. Consequently, the results obtained in this study demonstrate that GPM could contribute to the environmentally friendly and economical composting of problematic swine manure as a recyclable bulking agent.

  1. Structural Evidence for a Sequential Release Mechanism for Activation of Heterotrimeric G Proteins

    SciTech Connect

    Kapoor, Neeraj; Menon, Santosh T.; Chauhan, Radha; Sachdev, Pallavi; Sakmar, Thomas P.

    2010-01-12

    Heptahelical G-protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptors couple to heterotrimeric G proteins to relay extracellular signals to intracellular signaling networks, but the molecular mechanism underlying guanosine 5'-diphosphate (GDP) release by the G protein {alpha}-subunit is not well understood. Amino acid substitutions in the conserved {alpha}5 helix of Gi, which extends from the C-terminal region to the nucleotide-binding pocket, cause dramatic increases in basal (receptor-independent) GDP release rates. For example, mutant G{alpha}{sub i1}-T329A shows an 18-fold increase in basal GDP release rate and, when expressed in culture, it causes a significant decrease in forskolin-stimulated cAMP accumulation. The crystal structure of G{alpha}{sub i1}-T329A {center_dot} GDP shows substantial conformational rearrangement of the switch I region and additional striking alterations of side chains lining the catalytic pocket that disrupt the Mg{sup +2} coordination sphere and dislodge bound Mg{sup +2}. We propose a 'sequential release' mechanism whereby a transient conformational change in the {alpha}5 helix alters switch I to induce GDP release. Interestingly, this mechanistic model for heterotrimeric G protein activation is similar to that suggested for the activation of the plant small G protein Rop4 by RopGEF8.

  2. Handbook of synfuels technology

    SciTech Connect

    Meyers, R.A.

    1984-01-01

    This book explores various methods of producing synthetic fuels. Topics considered include coal liquefaction, Exxon Donor Solvent Coal Liquefaction Process, the H-Coal Process, the SRC-I Coal Liquefaction Process, the coal hydrogenation plant at Bottrop, production of liquid fuels from coal-derived synthesis gas, the Sasol plant, the ICI low pressure methanol process, Mobil Methanol-to-Gasoline (MTG) Process, the Lurgi low pressure methanol process, coal gasification the Texaco Coal Gasification Process, the Shell Coal Gasification Process, the Combustion Engineering Coal Gasification Process, British Gas/Lurgi Slagging Gasifier, KBW Coal Gasification, fluidized-bed coal gasification process (type Winkler), Lurgi coal gasification (dry bottom gasifier), Foster Wheeler Stoic Process, the WD-GI two stage coal gasifier, the Saarberg/Otto Coal Gasification Process, Allis-Chalmers KILnGAS Process, the purification of gases derived from coal, shale oil, Lurgi-Ruhrgas Process, the Tosco II Process, Paraho oil shale retorting processes, Occidental Modified In-Situ (MIS) Process, the geokinetics in-situ retorting process, oil shale pre-beneficiation, additional oil shale technologies, oil from oil sand, Suncor Hot Water Process, emerging technologies for oil from oil sands, synfuels upgrading and refining, Exxon fluid coking/flexicoking processes for synfuels upgrading applications, H-Oil processes, LC-Fining Process, and The Modified Litol Process for benzene production.

  3. Metastatic Melanoma Induced Metabolic Changes in C57BL/6J Mouse Stomach Measured by 1H NMR Spectroscopy

    SciTech Connect

    Hu, M; Wang, Xiliang

    2014-12-05

    Melanoma is a malignant tumor of melanocytes with high capability of invasion and rapid metastasis to other organs. Malignant melanoma is the most common metastatic malignancy found in gastrointestinal tract (GI). To the best of our knowledge, previous studies of melanoma in gastrointestinal tract are all clinical case reports. In this work, 1H NMR-based metabolomics approach is used to investigate the metabolite profiles differences of stomach tissue extracts of metastatic B16-F10 melanoma in C57BL/6J mouse and search for specific metabolite biomarker candidates. Principal Component Analysis (PCA), an unsupervised multivariate data analysis method, is used to detect possible outliers, while Orthogonal Projection to Latent Structure (OPLS), a supervised multivariate data analysis method, is employed to evaluate important metabolites responsible for discriminating the control and the melanoma groups. Both PCA and OPLS results reveal that the melanoma group can be well separated from its control group. Among the 50 identified metabolites, it is found that the concentrations of 19 metabolites are statistically and significantly changed with the levels of O-phosphocholine and hypoxanthine down-regulated while the levels of isoleucine, leucine, valine, isobutyrate, threonine, cadaverine, alanine, glutamate, glutamine, methionine, citrate, asparagine, tryptophan, glycine, serine, uracil, and formate up-regulated in the melanoma group. These significantly changed metabolites are associated with multiple biological pathways and may be potential biomarkers for metastatic melanoma in stomach.

  4. Defect sink characteristics of specific grain boundary types in 304 stainless steels under high dose neutron environments

    DOE PAGES [OSTI]

    Field, Kevin G.; Yang, Ying; Busby, Jeremy T.; Allen, Todd R.

    2015-03-09

    Radiation induced segregation (RIS) is a well-studied phenomena which occurs in many structurally relevant nuclear materials including austenitic stainless steels. RIS occurs due to solute atoms preferentially coupling to mobile point defect fluxes that migrate and interact with defect sinks. Here, a 304 stainless steel was neutron irradiated up to 47.1 dpa at 320 °C. Investigations into the RIS response at specific grain boundary types were utilized to determine the sink characteristics of different boundary types as a function of irradiation dose. A rate theory model built on the foundation of the modified inverse Kirkendall (MIK) model is proposed andmore » benchmarked to the experimental results. This model, termed the GiMIK model, includes alterations in the boundary conditions based on grain boundary structure and includes expressions for interstitial binding. This investigation, through experiment and modeling, found specific grain boundary structures exhibit unique defect sink characteristics depending on their local structure. Furthermore, such interactions were found to be consistent across all doses investigated and had larger global implications including precipitation of Ni-Si clusters near different grain boundary types.« less

  5. Code System for Evaluating Routine Radioactive Effluents from Nuclear Power Plants with Windows Interface.

    SciTech Connect

    MALAFEEW, VAL

    2012-12-12

    Version 14 NRCDose is a user-friendly 32-bit PC-based software interface for the LADTAP II, GASPAR II, and XOQDOQ programs which operates under all Microsoft WindowsTM platforms. LADTAP II, GASPAR II, and XOQDOQ are industry standards, originally created for mainframe computers and written using the Fortran programming language. While still utilizing the proven Fortran code modules, NRCDose allows the user to enter and retrieve data through a series of windows dialogs, making the use of the program much more user-friendly and efficient than its original design. This graphical interface also allows the user to create sets of data that can be named and retrieved at a later date for review or modification. The NRCDose program is equipped to perform calculations with up to 169 radionuclides, seven organs (bone, liver, total body, thyroid, kidney, lung, and GI-LLI) and four age ranges (infant, child, teenager, and adult). The source of the DCFs (dose conversion factors) in NRCDose is Regulatory Guide 1.109, supplemented with additional dose factors from NUREG-0172. See Abstract for recent modifications.

  6. Code System for Evaluating Routine Radioactive Effluents from Nuclear Power Plants with Windows Interface.

    Energy Science and Technology Software Center

    2012-12-12

    Version 14 NRCDose is a user-friendly 32-bit PC-based software interface for the LADTAP II, GASPAR II, and XOQDOQ programs which operates under all Microsoft WindowsTM platforms. LADTAP II, GASPAR II, and XOQDOQ are industry standards, originally created for mainframe computers and written using the Fortran programming language. While still utilizing the proven Fortran code modules, NRCDose allows the user to enter and retrieve data through a series of windows dialogs, making the use of themore » program much more user-friendly and efficient than its original design. This graphical interface also allows the user to create sets of data that can be named and retrieved at a later date for review or modification. The NRCDose program is equipped to perform calculations with up to 169 radionuclides, seven organs (bone, liver, total body, thyroid, kidney, lung, and GI-LLI) and four age ranges (infant, child, teenager, and adult). The source of the DCFs (dose conversion factors) in NRCDose is Regulatory Guide 1.109, supplemented with additional dose factors from NUREG-0172. See Abstract for recent modifications.« less

  7. Code System for Evaluating Routine Radioactive Effluents from Nuclear Power Plants with Windows Interface.

    Energy Science and Technology Software Center

    2012-12-13

    Version 03 NRCDose72 is a software program developed by Chesapeake Nuclear Services that integrates the NRC’s Fortran programs LADTAP II, GASPAR II, and XOQDOQ and provides a user-friendly interface for running the codes on a PC. These codes provide an accepted regulatory basis for assessing doses to the public as required for the licensing assessments for both license renewal and new build nuclear plants. Chesapeake Nuclear Services undertook an effort to update the dose conversionmore » factors (DCFs) used in NRCDose72 to the factors reported in ICRP-72, naming the new program NRCDose72. The original NRCDose72 program is equipped to perform calculations with up to 169 radionuclides, seven organs (bone, liver, total body, thyroid, kidney, lung, and GI-LLI) and four age ranges (infant, child, teenager, and adult). The ICRP-72 methodology contains additional parameters, including dose factors for 25 discrete organs, plus a remainder organ and effective DCF. Also, there are a total of six different age ranges (newborn, 1‑yr. old, 5-yr. old, 10-yr. old, 15-yr. old, and adult). Finally, ICRP-72 contains DCFs for a variety of chemical forms (H-3 as vapor or Organically Bound Tritium, for example) or inhalation classes (F, M or S for nearly all radionuclides). See Abstract for recent modifications.« less

  8. Energies and E1, M1, E2, and M2 transition rates for states of the 2s{sup 2}2p{sup 3}, 2s2p{sup 4}, and 2p{sup 5} configurations in nitrogen-like ions between F III and Kr XXX

    SciTech Connect

    Rynkun, P.; Jönsson, P.; Gaigalas, G.; Froese Fischer, C.

    2014-03-15

    Based on relativistic wavefunctions from multiconfiguration Dirac–Hartree–Fock and configuration interaction calculations, E1, M1, E2, and M2 transition rates, weighted oscillator strengths, and lifetimes are evaluated for the states of the (1s{sup 2})2s{sup 2}2p{sup 3},2s2p{sup 4}, and 2p{sup 5} configurations in all nitrogen-like ions between F III and Kr XXX. The wavefunction expansions include valence, core–valence, and core–core correlation effects through single–double multireference expansions to increasing sets of active orbitals. The computed energies agree very well with experimental values, with differences of only 300–600 cm{sup −1} for the majority of the levels and ions in the sequence. Computed transitions rates are in close agreement with available data from MCHF-BP calculations by Tachiev and Froese Fischer [G.I. Tachiev, C. Froese Fischer, A and A 385 (2002) 716].

  9. Opto-Electronic Characterization CdTe Solar Cells from TCO to Back Contact with Nano-Scale CL Probe

    SciTech Connect

    Moseley, John; Al-Jassim, Mowafak M.; Paudel, Naba; Mahabaduge, Hasitha; Kuciauskas, Darius; Guthrey, Harvey L.; Duenow, Joel; Yan, Yanfa; Metzger, Wyatt K.; Ahrenkiel, Richard K.

    2015-06-14

    We used cathodoluminescence (CL) (spectrum-per-pixel) imaging on beveled CdTe solar cell sections to investigate the opto-electronic properties of these devices from the TCO to the back contact. We used a nano-scale CL probe to resolve luminescence from grain boundary (GB) and grain interior (GI) locations near the CdS/CdTe interface where the grains are very small. As-deposited, CdCl2-treated, Cu-treated, and (CdCl2+Cu)-treated cells were analyzed. Color-coded CL spectrum imaging maps on bevels illustrate the distribution of the T=6 K luminescence transitions through the depth of devices with unprecedented spatial resolution. The CL at the GBs and GIs is shown to vary significantly from the front to the back of devices and is a sensitive function of processing. Supporting D-SIMS depth profile, TRPL lifetime, and C-V measurements are used to link the CL data to the J-V performance of devices.

  10. Regulatory analysis for the resolution of Generic Issue 143: Availability of chilled water system and room cooling

    SciTech Connect

    Leung, V.T.

    1993-12-01

    This report presents the regulatory analysis for Generic Issue (GI-143), {open_quotes}Availability of Chilled Water System and Room Cooling.{close_quotes} The heating, ventilating, and air conditioning (HVAC) systems and related auxiliaries are required to provide control of environmental conditions in areas in light water reactor (LWR) plants that contain safety-related equipment. In some plants, the HVAC and chilled water systems serve to maintain a suitable environment for both safety and non-safety-related areas. Although some plants have an independent chilled water system for the safety-related areas, the heat removal capability often depends on the operability of other supporting systems such as the service water system or the component cooling water system. The operability of safety-related components depends upon operation of the HVAC and chilled water systems to remove heat from areas containing the equipment. If cooling to dissipate the heat generated is unavailable, the ability of the safety-related equipment to operate as intended cannot be assured. Typical components or areas in the nuclear power plant that could be affected by the failure of cooling from HVAC or chilled water systems include the (1) emergency switchgear and battery rooms, (2) emergency diesel generator room, (3) pump rooms for residual heat removal, reactor core isolation cooling, high-pressure core spray, and low-pressure core spray, and (4) control room. The unavailability of such safety-related equipment or areas could cause the core damage frequency (CDF) to increase significantly.

  11. Advances in molecular serotyping and subtyping of Escherichia coli

    DOE PAGES [OSTI]

    Fratamico, Pina M.; DebRoy, Chitrita; Liu, Yanhong; Needleman, David S.; Baranzoni, Gian Marco; Feng, Peter

    2016-05-03

    Escherichia coli plays an important role as a member of the gut microbiota; however, pathogenic strains also exist, including various diarrheagenic E. coli pathotypes and extraintestinal pathogenic E. coli that cause illness outside of the GI-tract. E. coli have traditionally been serotyped using antisera against the ca. 186 O-antigens and 53 H-flagellar antigens. Phenotypic methods, including bacteriophage typing and O- and H- serotyping for differentiating and characterizing E. coli have been used for many years; however, these methods are generally time consuming and not always accurate. Advances in next generation sequencing technologies have made it possible to develop genetic-based subtypingmore » and molecular serotyping methods for E. coli, which are more discriminatory compared to phenotypic typing methods. Furthermore, whole genome sequencing (WGS) of E. coli is replacing established subtyping methods such as pulsedfield gel electrophoresis, providing a major advancement in the ability to investigate food-borne disease outbreaks and for trace-back to sources. Furthermore, a variety of sequence analysis tools and bioinformatic pipelines are being developed to analyze the vast amount of data generated by WGS and to obtain specific information such as O- and H-group determination and the presence of virulence genes and other genetic markers.« less

  12. Metastatic Melanoma Induced Metabolic Changes in C57BL/6J Mouse Stomach Measured by 1H NMR Spectroscopy

    DOE PAGES [OSTI]

    Hu, M; Wang, Xiliang

    2014-12-05

    Melanoma is a malignant tumor of melanocytes with high capability of invasion and rapid metastasis to other organs. Malignant melanoma is the most common metastatic malignancy found in gastrointestinal tract (GI). To the best of our knowledge, previous studies of melanoma in gastrointestinal tract are all clinical case reports. In this work, 1H NMR-based metabolomics approach is used to investigate the metabolite profiles differences of stomach tissue extracts of metastatic B16-F10 melanoma in C57BL/6J mouse and search for specific metabolite biomarker candidates. Principal Component Analysis (PCA), an unsupervised multivariate data analysis method, is used to detect possible outliers, while Orthogonalmore » Projection to Latent Structure (OPLS), a supervised multivariate data analysis method, is employed to evaluate important metabolites responsible for discriminating the control and the melanoma groups. Both PCA and OPLS results reveal that the melanoma group can be well separated from its control group. Among the 50 identified metabolites, it is found that the concentrations of 19 metabolites are statistically and significantly changed with the levels of O-phosphocholine and hypoxanthine down-regulated while the levels of isoleucine, leucine, valine, isobutyrate, threonine, cadaverine, alanine, glutamate, glutamine, methionine, citrate, asparagine, tryptophan, glycine, serine, uracil, and formate up-regulated in the melanoma group. These significantly changed metabolites are associated with multiple biological pathways and may be potential biomarkers for metastatic melanoma in stomach.« less

  13. Defect sink characteristics of specific grain boundary types in 304 stainless steels under high dose neutron environments

    SciTech Connect

    Field, Kevin G.; Yang, Ying; Allen, Todd R.; Busby, Jeremy T.

    2015-05-01

    Radiation induced segregation (RIS) is a well-studied phenomena which occurs in many structurally relevant nuclear materials including austenitic stainless steels. RIS occurs due to solute atoms preferentially coupling to mobile point defect fluxes that migrate and interact with defect sinks. Here, a 304 stainless steel was neutron irradiated up to 47.1 dpa at 320 °C. Investigations into the RIS response at specific grain boundary types were utilized to determine the sink characteristics of different boundary types as a function of irradiation dose. A rate theory model built on the foundation of the modified inverse Kirkendall (MIK) model is proposed and benchmarked to the experimental results. This model, termed the GiMIK model, includes alterations in the boundary conditions based on grain boundary structure and includes expressions for interstitial binding. This investigation, through experiment and modeling, found specific grain boundary structures exhibit unique defect sink characteristics depending on their local structure. Such interactions were found to be consistent across all doses investigated and had larger global implications including precipitation of Ni-Si clusters near different grain boundary types.

  14. Adaptive nonlocal means filtering based on local noise level for CT denoising

    SciTech Connect

    Li, Zhoubo; Trzasko, Joshua D.; Lake, David S.; Blezek, Daniel J.; Manduca, Armando; Yu, Lifeng; Fletcher, Joel G.; McCollough, Cynthia H.

    2014-01-15

    shape and peak frequency of the noise power spectrum better than commercial smoothing kernels, and indicate that the spatial resolution at low contrast levels is not significantly degraded. Both the subjective evaluation using the ACR phantom and the objective evaluation on a low-contrast detection task using a CHO model observer demonstrate an improvement on low-contrast performance. The GPU implementation can process and transfer 300 slice images within 5 min. On patient data, the adaptive NLM algorithm provides more effective denoising of CT data throughout a volume than standard NLM, and may allow significant lowering of radiation dose. After a two week pilot study of lower dose CT urography and CT enterography exams, both GI and GU radiology groups elected to proceed with permanent implementation of adaptive NLM in their GI and GU CT practices. Conclusions: This work describes and validates a computationally efficient technique for noise map estimation directly from CT images, and an adaptive NLM filtering based on this noise map, on phantom and patient data. Both the noise map calculation and the adaptive NLM filtering can be performed in times that allow integration with clinical workflow. The adaptive NLM algorithm provides effective denoising of CT data throughout a volume, and may allow significant lowering of radiation dose.

  15. Mechanisms underlying cellular responses of cells from haemopoietic tissue to low

    SciTech Connect

    Kadhim, Munira A

    2012-08-22

    The above studies will provide fundamental mechanistic information relating genetic predisposition to important low dose phenomena, and will aid in the development of Department of Energy policy, as well as radiation risk policy for the public and the workplace. We believe the proposed studies accurately reflect the goals of the DOE low dose program. To accurately define the risks associated with human exposure to relevant environmental doses of low LET ionizing radiation, it is necessary to completely understand the biological effects at very low doses (i.e. less than 0.1 Gy), including the lowest possible dose, that of a single electron track traversal. At such low doses, a range of studies have shown responses in biological systems which are not related to the direct interaction of radiation tracks with DNA. The role of these "œnon-targeted" responses in critical tissues is poorly understood and little is known regarding the underlying mechanisms. Although critical for dosimetry and risk assessment, the role of individual genetic susceptibility in radiation risk is not satisfactorily defined at present. The aim of the proposed grant is to critically evaluate non-targeted effects of ionizing radiation with a focus on the induction of genomic instability (GI) in key stem cell populations from haemopoietic tissue. Using stem cells from two mouse strains (CBA/CaH and C57BL/6J) known to differ in their susceptibility to radiation effects, we plan to carefully dissect the role of genetic predisposition in these models on genomic instability. We will specifically focus on the effects of low doses of low LET radiation, down to the dose of 10mGy (0.01Gy) X-rays. Using conventional X-ray and we will be able to assess the role of genetic variation under various conditions at a range of doses down to the very low dose of 0.01Gy. Irradiations will be carried out using facilities in routine operation for such studies. Mechanistic studies of instability in

  16. Toxicity assessments of nonsteroidal anti-inflammatory drugs in isolated mitochondria, rat hepatocytes, and zebrafish show good concordance across chemical classes

    SciTech Connect

    Nadanaciva, Sashi; Aleo, Michael D.; Strock, Christopher J.; Stedman, Donald B.; Wang, Huijun; Will, Yvonne

    2013-10-15

    To reduce costly late-stage compound attrition, there has been an increased focus on assessing compounds in in vitro assays that predict attributes of human safety liabilities, before preclinical in vivo studies are done. Relevant questions when choosing a panel of assays for predicting toxicity are (a) whether there is general concordance in the data among the assays, and (b) whether, in a retrospective analysis, the rank order of toxicity of compounds in the assays correlates with the known safety profile of the drugs in humans. The aim of our study was to answer these questions using nonsteroidal anti-inflammatory drugs (NSAIDs) as a test set since NSAIDs are generally associated with gastrointestinal injury, hepatotoxicity, and/or cardiovascular risk, with mitochondrial impairment and endoplasmic reticulum stress being possible contributing factors. Eleven NSAIDs, flufenamic acid, tolfenamic acid, mefenamic acid, diclofenac, meloxicam, sudoxicam, piroxicam, diflunisal, acetylsalicylic acid, nimesulide, and sulindac (and its two metabolites, sulindac sulfide and sulindac sulfone), were tested for their effects on (a) the respiration of rat liver mitochondria, (b) a panel of mechanistic endpoints in rat hepatocytes, and (c) the viability and organ morphology of zebrafish. We show good concordance for distinguishing among/between NSAID chemical classes in the observations among the three approaches. Furthermore, the assays were complementary and able to correctly identify “toxic” and “non-toxic” drugs in accordance with their human safety profile, with emphasis on hepatic and gastrointestinal safety. We recommend implementing our multi-assay approach in the drug discovery process to reduce compound attrition. - Highlights: • NSAIDS cause liver and GI toxicity. • Mitochondrial uncoupling contributes to NSAID liver toxicity. • ER stress is a mechanism that contributes to liver toxicity. • Zebrafish and cell based assays are complimentary.

  17. Feasibility of IMRT to Cover Pelvic Nodes While Escalating the Dose to the Prostate Gland: Dosimetric Data on 35 Consecutive Patients

    SciTech Connect

    Bayouth, John E. Pena, John; Culp, Laura; Brack, Collin; Sanguineti, Giuseppe

    2008-10-01

    Utilizing available dosimetric and acute toxicity data, we confirm the feasibility of intensity modulated radiotherapy (IMRT) to include treatment of the pelvic nodes (PN) while escalating the dose to the prostate. Data were obtained from 35 consecutive patients with prostate cancer with {>=}15% risk of PN involvement. Patients received an initial boost to the prostate, delivering 16 Gy over 8 fractions using a 6-field conformal technique, followed by an 8-field coplanar inverse planning IMRT technique delivering an additional 60 Gy over 30 fractions to the prostate (76 Gy total) and 54 Gy over 30 fractions to the seminal vesicles (SV) and PN. Dose-volume histogram analysis was performed for planning target volumes and organs at risk. Acute toxicity (RTOG/EORTC scale) was prospectively and independently scored weekly for each patient. The maximum, mean, minimum dose, and D95 to each planning target volume is provided: prostate (82.2, 78.2, 72.6, 75.2 Gy), SV (79.0, 72.5, 56.9, 61.1 Gy), and PN (80.4, 59.7, 46.5, 53.3 Gy), respectively. The percent volume receiving a dose at or above 'x' Gy (Vx) was recorded for V75, V70, V65, V60, and V50 as: bladder (14%, 24%, 32%, 39%, and 54%) and rectum (3%, 18%, 26%, 34%, and 51%), respectively. Acute toxicity was as follows: 54% grade 2+ GI (n = 19), 25% grade 2+ GU (n = 9). IMRT enables treatment of pelvic nodes while escalating dose to the prostate and is clinically feasible with acute toxicity within expected ranges.

  18. Biomaterials for the Decorporation of Sr-85 in the Rat

    SciTech Connect

    Levitskaia, Tatiana G.; Creim, Jeffrey A.; Curry, Terry L.; Luders, Teresa; Morris, James E.; Peterson, James M.; Thrall, Karla D.

    2010-09-01

    Although four stable isotopes of strontium occur naturally, strontium-90 is produced by nuclear fission and is present in surface soil around the world as a result of fallout from atmospheric nuclear weapons tests. It can easily transfer to man in the event of a nuclear/radiological emergency or through the plant-animal-human food chain causing long-term exposures. Strontium is chemically and biologically similar to calcium, and is incorporated primarily into bone following internal deposition. Alginic acid (alginate) obtained from seaweed (kelp) extract selectively binds ingested strontium in the GI tract blocking its systemic uptake and reducing distribution to bone in rats, while other natural polysaccharides including chitosan and hyaluronic acid had little in vivo affinity for strontium. Alginate exhibits the unique ability to discriminate between strontium and calcium and has been previously shown to reduce intestinal absorption and skeletal retention of strontium without changing calcium metabolism. In our studies, the effect of commercially available alginate on strontium intestinal absorption was examined. One problem associated with alginate treatment is its limited solubility and gel formation in water. The aqueous solubility of sodium alginate was improved in a sodium chloride/sodium bicarbonate electrolyte solution containing low molecular weight polyethylene glycol (PEG). Furthermore, oral administration of the combined alginate/electrolyte//PEG solution synergistically accelerated removal of internal strontium in rats when compared to treatment with individual sodium alginate/electrolyte or electrolyte/PEG solutions. Importantly, both alginate and PEG are nontoxic, readily available materials that can be easily administered orally in case of a national emergency when potentially large numbers of the population may require medical treatment for internal depositions. Our results suggest further studies to optimize in vivo decorporation performance of

  19. Neurotoxicological effects of cinnabar (a Chinese mineral medicine, HgS) in mice

    SciTech Connect

    Huang, C.-F.; Liu, S.-H.; Lin-Shiau, S.-Y.

    2007-10-15

    Cinnabar, a naturally occurring mercuric sulfide (HgS), has long been used in combination with traditional Chinese medicine as a sedative for more than 2000 years. Up to date, its pharmacological and toxicological effects are still unclear, especially in clinical low-dose and long-term use. In this study, we attempted to elucidate the effects of cinnabar on the time course of changes in locomotor activities, pentobarbital-induced sleeping time, motor equilibrium performance and neurobiochemical activities in mice during 3- to 11-week administration at a clinical dose of 10 mg/kg/day. The results showed that cinnabar was significantly absorbed by gastrointestinal (G-I) tract and transported to brain tissues. The spontaneous locomotor activities of male mice but not female mice were preferentially suppressed. Moreover, frequencies of jump and stereotype-1 episodes were progressively decreased after 3-week oral administration in male and female mice. Pentobarbital-induced sleeping time was prolonged and the retention time on a rotating rod (60 rpm) was reduced after treatment with cinnabar for 6 weeks and then progressively to a greater extent until the 11-week experiment. In addition, the biochemical changes in blood and brain tissues were studied; the inhibition of Na{sup +}/K{sup +}-ATPase activities, increased production of lipid peroxidation (LPO) and nitric oxide (NO) were found with a greater extent in male mice than those in female mice, which were apparently correlated with their differences in the neurological responses observed. In conclusion, these findings, for the first time, provide evidence of the pharmacological and toxicological basis for understanding the sedative and neurotoxic effects of cinnabar used as a Chinese mineral medicine for more than 2000 years.

  20. A revised model of ex-vivo reduction of hexavalent chromium in human and rodent gastric juices

    SciTech Connect

    Schlosser, Paul M. Sasso, Alan F.

    2014-10-15

    Chronic oral exposure to hexavalent chromium (Cr-VI) in drinking water has been shown to induce tumors in the mouse gastrointestinal (GI) tract and rat oral cavity. The same is not true for trivalent chromium (Cr-III). Thus reduction of Cr-VI to Cr-III in gastric juices is considered a protective mechanism, and it has been suggested that the difference between the rate of reduction among mice, rats, and humans could explain or predict differences in sensitivity to Cr-VI. We evaluated previously published models of gastric reduction and believe that they do not fully describe the data on reduction as a function of Cr-VI concentration, time, and (in humans) pH. The previous models are parsimonious in assuming only a single reducing agent in rodents and describing pH-dependence using a simple function. We present a revised model that assumes three pools of reducing agents in rats and mice with pH-dependence based on known speciation chemistry. While the revised model uses more fitted parameters than the original model, they are adequately identifiable given the available data, and the fit of the revised model to the full range of data is shown to be significantly improved. Hence the revised model should provide better predictions of Cr-VI reduction when integrated into a corresponding PBPK model. - Highlights: • Hexavalent chromium (Cr-VI) reduction in gastric juices is a key detoxifying step. • pH-dependent Cr-VI reduction rates are explained using known chemical speciation. • Reduction in rodents appears to involve multiple pools of electron donors. • Reduction appears to continue after 60 min, although more slowly than initial rates.

  1. CONVERGENCE STUDIES OF MASS TRANSPORT IN DISKS WITH GRAVITATIONAL INSTABILITIES. II. THE RADIATIVE COOLING CASE

    SciTech Connect

    Steiman-Cameron, Thomas Y.; Durisen, Richard H.; Michael, Scott; McConnell, Caitlin R.; Boley, Aaron C. E-mail: durisen@astro.indiana.edu E-mail: carmccon@indiana.edu

    2013-05-10

    We conduct a convergence study of a protoplanetary disk subject to gravitational instabilities (GIs) at a time of approximate balance between heating produced by the GIs and radiative cooling governed by realistic dust opacities. We examine cooling times, characterize GI-driven spiral waves and their resultant gravitational torques, and evaluate how accurately mass transport can be represented by an {alpha}-disk formulation. Four simulations, identical except for azimuthal resolution, are conducted with a grid-based three-dimensional hydrodynamics code. There are two regions in which behaviors differ as resolution increases. The inner region, which contains 75% of the disk mass and is optically thick, has long cooling times and is well converged in terms of various measures of structure and mass transport for the three highest resolutions. The longest cooling times coincide with radii where the Toomre Q has its minimum value. Torques are dominated in this region by two- and three-armed spirals. The effective {alpha} arising from gravitational stresses is typically a few Multiplication-Sign 10{sup -3} and is only roughly consistent with local balance of heating and cooling when time-averaged over many dynamic times and a wide range of radii. On the other hand, the outer disk region, which is mostly optically thin, has relatively short cooling times and does not show convergence as resolution increases. Treatment of unstable disks with optical depths near unity with realistic radiative transport is a difficult numerical problem requiring further study. We discuss possible implications of our results for numerical convergence of fragmentation criteria in disk simulations.

  2. Structural and Mechanistic Roles of Novel Chemical Ligands on the SdiA Quorum-Sensing Transcription Regulator

    DOE PAGES [OSTI]

    Nguyen, Y.; Nguyen, Nam X.; Rogers, Jamie L.; Liao, Jun; MacMillan, John B.; Jiang, Youxing; Sperandio, Vanessa

    2015-05-19

    Bacteria engage in chemical signaling, termed quorum sensing (QS), to mediate intercellular communication, mimicking multicellular organisms. The LuxR family of QS transcription factors regulates gene expression, coordinating population behavior by sensing endogenous acyl homoserine lactones (AHLs). However, some bacteria (such as Escherichia coli) do not produce AHLs. These LuxR orphans sense exogenous AHLs but also regulate transcription in the absence of AHLs. Importantly, this AHL-independent regulatory mechanism is still largely unknown. Here we present several structures of one such orphan LuxR-type protein, SdiA, from enterohemorrhagic E. coli (EHEC), in the presence and absence of AHL. SdiA is actually not inmore » an apo state without AHL but is regulated by a previously unknown endogenous ligand, 1-octanoyl-rac-glycerol (OCL), which is ubiquitously found throughout the tree of life and serves as an energy source, signaling molecule, and substrate for membrane biogenesis. While exogenous AHL renders to SdiA higher stability and DNA binding affinity, OCL may function as a chemical chaperone placeholder that stabilizes SdiA, allowing for basal activity. Structural comparison between SdiA-AHL and SdiA-OCL complexes provides crucial mechanistic insights into the ligand regulation of AHL-dependent and -independent function of LuxR-type proteins. Importantly, in addition to its contribution to basic science, this work has implications for public health, inasmuch as the SdiA signaling system aids the deadly human pathogen EHEC to adapt to a commensal lifestyle in the gastrointestinal (GI) tract of cattle, its main reservoir. These studies open exciting and novel avenues to control shedding of this human pathogen in the environment. IMPORTANCE Quorum sensing refers to bacterial chemical signaling. The QS acyl homoserine lactone (AHL) signals are recognized by LuxR-type receptors that regulate gene transcription. However, some bacteria have orphan Lux

  3. Structural and Mechanistic Roles of Novel Chemical Ligands on the SdiA Quorum-Sensing Transcription Regulator

    SciTech Connect

    Nguyen, Y.; Nguyen, Nam X.; Rogers, Jamie L.; Liao, Jun; MacMillan, John B.; Jiang, Youxing; Sperandio, Vanessa

    2015-05-19

    Bacteria engage in chemical signaling, termed quorum sensing (QS), to mediate intercellular communication, mimicking multicellular organisms. The LuxR family of QS transcription factors regulates gene expression, coordinating population behavior by sensing endogenous acyl homoserine lactones (AHLs). However, some bacteria (such as Escherichia coli) do not produce AHLs. These LuxR orphans sense exogenous AHLs but also regulate transcription in the absence of AHLs. Importantly, this AHL-independent regulatory mechanism is still largely unknown. Here we present several structures of one such orphan LuxR-type protein, SdiA, from enterohemorrhagic E. coli (EHEC), in the presence and absence of AHL. SdiA is actually not in an apo state without AHL but is regulated by a previously unknown endogenous ligand, 1-octanoyl-rac-glycerol (OCL), which is ubiquitously found throughout the tree of life and serves as an energy source, signaling molecule, and substrate for membrane biogenesis. While exogenous AHL renders to SdiA higher stability and DNA binding affinity, OCL may function as a chemical chaperone placeholder that stabilizes SdiA, allowing for basal activity. Structural comparison between SdiA-AHL and SdiA-OCL complexes provides crucial mechanistic insights into the ligand regulation of AHL-dependent and -independent function of LuxR-type proteins. Importantly, in addition to its contribution to basic science, this work has implications for public health, inasmuch as the SdiA signaling system aids the deadly human pathogen EHEC to adapt to a commensal lifestyle in the gastrointestinal (GI) tract of cattle, its main reservoir. These studies open exciting and novel avenues to control shedding of this human pathogen in the environment. IMPORTANCE Quorum sensing refers to bacterial chemical signaling. The QS acyl homoserine lactone (AHL) signals are recognized by LuxR-type receptors that regulate gene transcription. However, some bacteria have orphan LuxR-type receptors and

  4. SU-E-T-629: Feasibility Study of Treating Multiple Brain Tumors with Large Number of Noncoplanar IMRT Beams

    SciTech Connect

    Dong, P; Ma, L

    2014-06-15

    Purpose: To study the feasibility of treating multiple brain tumors withlarge number of noncoplanar IMRT beams. Methods: Thirty beams are selected from 390 deliverable beams separated by six degree in 4pi space. Beam selection optimization is based on a column generation algorithm. MLC leaf size is 2 mm. Dose matrices are calculated with collapsed cone convolution and superposition method in a 2 mm by 2mm by 2 mm grid. Twelve brain tumors of various shapes, sizes and locations are used to generate four plans treating 3, 6, 9 and 12 tumors. The radiation dose was 20 Gy prescribed to the 100% isodose line. Dose Volume Histograms for tumor and brain were compared. Results: All results are based on a 2 mm by 2 mm by 2 mm CT grid. For 3, 6, 9 and 12 tumor plans, minimum tumor doses are all 20 Gy. Mean tumor dose are 20.0, 20.1, 20.1 and 20.1 Gy. Maximum tumor dose are 23.3, 23.6, 25.4 and 25.4 Gy. Mean ventricles dose are 0.7, 1.7, 2.4 and 3.1 Gy.Mean subventricular zone dose are 0.8, 1.3, 2.2 and 3.2 Gy. Average Equivalent uniform dose (gEUD) values for tumor are 20.1, 20.1, 20.2 and 20.2 Gy. The conformity index (CI) values are close to 1 for all 4 plans. The gradient index (GI) values are 2.50, 2.05, 2.09 and 2.19. Conclusion: Compared with published Gamma Knife treatment studies, noncoplanar IMRT treatment plan is superior in terms of dose conformity. Due to maximum limit of beams per plan, Gamma knife has to treat multiple tumors separately in different plans. Noncoplanar IMRT plans theoretically can be delivered in a single plan on any modern linac with an automated couch and image guidance. This warrants further study of using noncoplanar IMRT as a viable treatment solution for multiple brain tumors.

  5. Five Fractions of Radiation Therapy Followed by 4 Cycles of FOLFOX Chemotherapy as Preoperative Treatment for Rectal Cancer

    SciTech Connect

    Myerson, Robert J.; Tan, Benjamin; Hunt, Steven; Olsen, Jeffrey; Birnbaum, Elisa; Fleshman, James; Gao, Feng; Hall, Lannis; Kodner, Ira; Lockhart, A. Craig; Mutch, Matthew; Naughton, Michael; Picus, Joel; Rigden, Caron; Safar, Bashar; Sorscher, Steven; Suresh, Rama; Wang-Gillam, Andrea; Parikh, Parag

    2014-03-15

    Background: Preoperative radiation therapy with 5-fluorouracil chemotherapy is a standard of care for cT3-4 rectal cancer. Studies incorporating additional cytotoxic agents demonstrate increased morbidity with little benefit. We evaluate a template that: (1) includes the benefits of preoperative radiation therapy on local response/control; (2) provides preoperative multidrug chemotherapy; and (3) avoids the morbidity of concurrent radiation therapy and multidrug chemotherapy. Methods and Materials: Patients with cT3-4, any N, any M rectal cancer were eligible. Patients were confirmed to be candidates for pelvic surgery, provided response was sufficient. Preoperative treatment was 5 fractions radiation therapy (25 Gy to involved mesorectum, 20 Gy to elective nodes), followed by 4 cycles of FOLFOX [5-fluorouracil, oxaliplatin, leucovorin]. Extirpative surgery was performed 4 to 9 weeks after preoperative chemotherapy. Postoperative chemotherapy was at the discretion of the medical oncologist. The principal objectives were to achieve T stage downstaging (ypT < cT) and preoperative grade 3+ gastrointestinal morbidity equal to or better than that of historical controls. Results: 76 evaluable cases included 7 cT4 and 69 cT3; 59 (78%) cN+, and 7 cM1. Grade 3 preoperative GI morbidity occurred in 7 cases (9%) (no grade 4 or 5). Sphincter-preserving surgery was performed on 57 (75%) patients. At surgery, 53 patients (70%) had ypT0-2 residual disease, including 21 (28%) ypT0 and 19 (25%) ypT0N0 (complete response); 24 (32%) were ypN+. At 30 months, local control for all evaluable cases and freedom from disease for M0 evaluable cases were, respectively, 95% (95% confidence interval [CI]: 89%-100%) and 87% (95% CI: 76%-98%). Cases were subanalyzed by whether disease met requirements for the recently activated PROSPECT trial for intermediate-risk rectal cancer. Thirty-eight patients met PROSPECT eligibility and achieved 16 ypT0 (42%), 15 ypT0N0 (39%), and 33 ypT0-2 (87

  6. Extracellular acidification synergizes with PDGF to stimulate migration of mouse embryo fibroblasts through activation of p38MAPK with a PTX-sensitive manner

    SciTech Connect

    An, Caiyan; Sato, Koichi; Wu, Taoya; Bao, Muqiri; Bao, Liang; Tobo, Masayuki; Damirin, Alatangaole

    2015-05-01

    The elucidation of the functional mechanisms of extracellular acidification stimulating intracellular signaling pathway is of great importance for developing new targets of treatment for solid tumors, and inflammatory disorders characterized by extracellular acidification. In the present study, we focus on the regulation of extracellular acidification on intracellular signaling pathways in mouse embryo fibroblasts (MEFs). We found extracellular acidification was at least partly involved in stimulating p38MAPK pathway through PTX-sensitive behavior to enhance cell migration in the presence or absence of platelet-derived growth factor (PDGF). Statistical analysis showed that the actions of extracellular acidic pH and PDGF on inducing enhancement of cell migration were not an additive effect. However, we also found extracellular acidic pH did inhibit the viability and proliferation of MEFs, suggesting that extracellular acidification stimulates cell migration probably through proton-sensing mechanisms within MEFs. Using OGR1-, GPR4-, and TDAG8-gene knock out technology, and real-time qPCR, we found known proton-sensing G protein-coupled receptors (GPCRs), transient receptor potential vanilloid subtype 1 (TRPV1), and acid-sensing ion channels (ASICs) were unlikely to be involved in the regulation of acidification on cell migration. In conclusion, our present study validates that extracellular acidification stimulates chemotactic migration of MEFs through activation of p38MAPK with a PTX-sensitive mechanism either by itself, or synergistically with PDGF, which was not regulated by the known proton-sensing GPCRs, TRPV1, or ASICs. Our results suggested that others proton-sensing GPCRs or ion channels might exist in MEFs, which mediates cell migration induced by extracellular acidification in the presence or absence of PDGF. - Highlights: • Acidic pH and PDGF synergize to stimulate MEFs migration via Gi/p38MAPK pathway. • Extracellular acidification inhibits the

  7. Cosmic Voids and Void Lensing in the Dark Energy Survey Science Verification Data

    DOE PAGES [OSTI]

    Sánchez, C.; Clampitt, J.; Kovacs, A.; Jain, B.; García-Bellido, J.; Nadathur, S.; Gruen, D.; Hamaus, N.; Huterer, D.; Vielzeuf, P.; et al

    2016-10-26

    Galaxies and their dark matter halos populate a complicated filamentary network around large, nearly empty regions known as cosmic voids. Cosmic voids are usually identified in spectroscopic galaxy surveys, where 3D information about the large-scale structure of the Universe is available. Although an increasing amount of photometric data is being produced, its potential for void studies is limited since photometric redshifts induce line-of-sight position errors of ~50 Mpc/h or more that can render many voids undetectable. In this paper we present a new void finder designed for photometric surveys, validate it using simulations, and apply it to the high-quality photo-zmore » redMaGiC galaxy sample of the Dark Energy Survey Science Verification (DES-SV) data. The algorithm works by projecting galaxies into 2D slices and finding voids in the smoothed 2D galaxy density field of the slice. Fixing the line-of-sight size of the slices to be at least twice the photo- z scatter, the number of voids found in these projected slices of simulated spectroscopic and photometric galaxy catalogs is within 20% for all transverse void sizes, and indistinguishable for the largest voids of radius ~70 Mpc/h and larger. The positions, radii, and projected galaxy profiles of photometric voids also accurately match the spectroscopic void sample. Applying the algorithm to the DES-SV data in the redshift range 0.2 < z < 0.8 , we identify 87 voids with comoving radii spanning the range 18-120 Mpc/h, and carry out a stacked weak lensing measurement. With a significance of 4.4σ, the lensing measurement confirms the voids are truly underdense in the matter field and hence not a product of Poisson noise, tracer density effects or systematics in the data. In conclusion, it also demonstrates, for the first time in real data, the viability of void lensing studies in photometric surveys.« less

  8. CHP Integrated with Burners for Packaged Boilers

    SciTech Connect

    Castaldini, Carlo; Darby, Eric

    2013-09-30

    division of Sempra Energy. These match funds were provided via concurrent contracts and investments available via CMCE, Altex, and Leva Energy The project attained all its objectives and is considered a success. CMCE secured the support of GI&E from Italy to supply 100 kW Turbec T-100 microturbines for the project. One was purchased by the project’s subcontractor, Altex, and a second spare was purchased by CMCE under this project. The microturbines were then modified to convert from their original recuperated design to a simple cycle configuration. Replacement low-NOx silo combustors were designed and bench tested in order to achieve compliance with the California Air Resources Board (CARB) 2007 emission limits for NOx and CO when in CHP operation. The converted microturbine was then mated with a low NOx burner provided by Altex via an integration section that allowed flow control and heat recovery to minimize combustion blower requirements; manage burner turndown; and recover waste heat. A new fully integrated control system was designed and developed that allowed one-touch system operation in all three available modes of operation: (1) CHP with both microturbine and burner firing for boiler heat input greater than 2 MMBtu/hr; (2) burner head only (BHO) when the microturbine is under service; and (3) microturbine only when boiler heat input requirements fall below 2 MMBtu/hr. This capability resulted in a burner turndown performance of nearly 10/1, a key advantage for this technology over conventional low NOx burners. Key components were then assembled into a cabinet with additional support systems for generator cooling and fuel supply. System checkout and performance tests were performed in the laboratory. The assembled system and its support equipment were then shipped and installed at a host facility where final performance tests were conducted following efforts to secure fabrication, air, and operating permits. The installed power burner is now in commercial

  9. Multifunctional Metallic and Refractory Materials for Energy Efficient Handling of Molten Metals

    SciTech Connect

    Xingbo Liu; Ever Barbero; Bruce Kang; Bhaskaran Gopalakrishnan; James Headrick; Carl Irwin

    2009-02-06

    The goal of the project was to extend the lifetime of hardware submerged in molten metal by an order of magnitude and to improve energy efficiency of molten metal handling process. Assuming broad implementation of project results, energy savings in 2020 were projected to be 10 trillion BTU/year, with cost savings of approximately $100 million/year. The project team was comprised of materials research groups from West Virginia University and the Missouri University of Science and Technology formerly University of Missouri – Rolla, Oak Ridge National Laboratory, International Lead and Zinc Research Organization, Secat and Energy Industries of Ohio. Industry partners included six suppliers to the hot dip galvanizing industry, four end-user steel companies with hot-dip Galvanize and/or Galvalume lines, eight refractory suppliers, and seven refractory end-user companies. The results of the project included the development of: (1) New families of materials more resistant to degradation in hot-dip galvanizing bath conditions were developed; (2) Alloy 2020 weld overlay material and process were developed and applied to GI rolls; (3) New Alloys and dross-cleaning procedures were developed for Galvalume processes; (4) Two new refractory compositions, including new anti-wetting agents, were identified for use with liquid aluminum alloys; (5) A new thermal conductivity measurement technique was developed and validated at ORNL; (6) The Galvanizing Energy Profiler Decision Support System (GEPDSS)at WVU; Newly Developed CCW Laser Cladding Shows Better Resistance to Dross Buildup than 316L Stainless Steel; and (7) A novel method of measuring the corrosion behavior of bath hardware materials. Project in-line trials were conducted at Southwire Kentucky Rod and Cable Mill, Nucor-Crawfordsville, Nucor-Arkansas, Nucor-South Carolina, Wheeling Nisshin, California Steel, Energy Industries of Ohio, and Pennex Aluminum. Cost, energy, and environmental benefits resulting from the project

  10. Central and Eastern United States (CEUS) Seismic Source Characterization (SSC) for Nuclear Facilities Project

    SciTech Connect

    Kevin J. Coppersmith; Lawrence A. Salomone; Chris W. Fuller; Laura L. Glaser; Kathryn L. Hanson; Ross D. Hartleb; William R. Lettis; Scott C. Lindvall; Stephen M. McDuffie; Robin K. McGuire; Gerry L. Stirewalt; Gabriel R. Toro; Robert R. Youngs; David L. Slayter; Serkan B. Bozkurt; Randolph J. Cumbest; Valentina Montaldo Falero; Roseanne C. Perman' Allison M. Shumway; Frank H. Syms; Martitia P. Tuttle

    2012-01-31

    Seismic Hazard Analysis: Guidance on Uncertainty and Use of Experts. The model will be used to assess the present-day composite distribution for seismic sources along with their characterization in the CEUS and uncertainty. In addition, this model is in a form suitable for use in PSHA evaluations for regulatory activities, such as Early Site Permit (ESPs) and Combined Operating License Applications (COLAs). Applications, Values, and Use Development of a regional CEUS seismic source model will provide value to those who (1) have submitted an ESP or COLA for Nuclear Regulatory Commission (NRC) review before 2011; (2) will submit an ESP or COLA for NRC review after 2011; (3) must respond to safety issues resulting from NRC Generic Issue 199 (GI-199) for existing plants and (4) will prepare PSHAs to meet design and periodic review requirements for current and future nuclear facilities. This work replaces a previous study performed approximately 25 years ago. Since that study was completed, substantial work has been done to improve the understanding of seismic sources and their characterization in the CEUS. Thus, a new regional SSC model provides a consistent, stable basis for computing PSHA for a future time span. Use of a new SSC model reduces the risk of delays in new plant licensing due to more conservative interpretations in the existing and future literature. Perspective The purpose of this study, jointly sponsored by EPRI, the U.S. Department of Energy (DOE), and the NRC was to develop a new CEUS SSC model. The team assembled to accomplish this purpose was composed of distinguished subject matter experts from industry, government, and academia. The resulting model is unique, and because this project has solicited input from the present-day larger technical community, it is not likely that there will be a need for significant revision for a number of years. See also Sponsors Perspective for more details. The goal of this project was to implement the CEUS SSC work plan