National Library of Energy BETA

Sample records for geneva il il

  1. HIA 2015 DOE Zero Energy Ready Home Case Study: Evolutionary Home Builders, The Adaptation Home, Geneva, IL

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Evolutionary Home Builders The Adaptation Home Geneva, IL DOE ZERO ENERGY READY HOME(tm) The U.S. Department of Energy invites home builders across the country to meet the extraordinary levels of excellence and quality specified in DOE's Zero Energy Ready Home program (formerly known as Challenge Home). Every DOE Zero Energy Ready Home starts with ENERGY STAR Certified Homes Version 3.0 for an energy-efficient home built on a solid foundation of building science research. Advanced technologies

  2. City of Geneva, Illinois (Utility Company) | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Geneva Place: Illinois Phone Number: 630-232-1503 Website: www.geneva.il.usindex.aspx?NI Twitter: @CityofGeneva Facebook: https:www.facebook.comgeneva.il Outage Hotline:...

  3. IL FS Ecosmart Ltd | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Services Product: IL&FS Ecosmart Ltd., a subsidiary of the Infrastructure Leasing & Financial Services (IL&FS) Group, provides environmental services. References: IL&FS...

  4. IL Wted States Government

    Office of Legacy Management (LM)

    Tis&: p/WI-3 . IL Wted States Government ' 1, -1. \ k. 4 4L La. -iF 1 I ' __, 7, Department of Energy memorandum <jj ' 5 - ; +- ,I 12 ~ DATE: OCT 08 1992 REPLY TO AlTN OF: EM-421 (W. A. Williams, 903-8149) rn. I \ SUBJECT: Authorization for Remedial Action at the Former C. H. Schnoor & Company Site, Springdale, Pennsylvania TO: Manager, DOE Oak Ridge Field Office This is to notify you that the former C. H. Schnoor & Company facility in Springdale, Pennsylvania, is designated for

  5. US ENC IL Site Consumption

    Energy Information Administration (EIA) (indexed site)

    IL Site Consumption million Btu $0 $500 $1,000 $1,500 $2,000 $2,500 US ENC IL Expenditures dollars ALL ENERGY average per household (excl. transportation) 0 2,000 4,000 6,000 8,000 10,000 12,000 US ENC IL Site Consumption kilowatthours $0 $250 $500 $750 $1,000 $1,250 $1,500 US ENC IL Expenditures dollars ELECTRICITY ONLY average per household * Illinois households use 129 million Btu of energy per home, 44% more than the U.S. average. * High consumption, combined with low costs for heating fuels

  6. Category:Chicago, IL | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    74 KB SVHospital Chicago IL Commonwealth Edison Co.png SVHospital Chicago IL ... 68 KB SVLargeHotel Chicago IL Commonwealth Edison Co.png SVLargeHotel Chicago I... 75 KB...

  7. US ENC IL Site Consumption

    Annual Energy Outlook

    ... Yes Yes No No 0% 20% 40% 60% 80% 100% US IL No Car CAR IS PARKED WITHIN 20 FT OF ELECTRICAL OUTLET More highlights from RECS on housing characteristics and energy-related ...

  8. Category:Springfield, IL | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Springfield IL Commonwealth Edison Co.png SVQuickServiceRestaura... 75 KB SVFullServiceRestaurant Springfield IL Commonwealth Edison Co.png...

  9. DOE - Office of Legacy Management -- Chicago North IL Site - IL 05

    Office of Legacy Management (LM)

    North IL Site - IL 05 FUSRAP Considered Sites Chicago North, IL Alternate Name(s): National Guard Armory 124th Field Artillery Armory Illinois National Guard Armory Site IL.05-4 IL.05-5 Location: 5200 Cottage Grove Avenue, Chicago, Illinois IL.05-4 Historical Operations: Processed and stored uranium metal, resulting in uranium metal and dry uranium oxide contamination. Metallurgical operations were conducted by the University of Chicago, an MED contractor. IL.05-5 IL.05-7 IL.05-8 Eligibility

  10. Characterization of interleukin-15 (IL-15) and the IL-15 receptor complex

    SciTech Connect

    Kennedy, M.K.; Park, L.S.

    1996-05-01

    IL-15 interacts with a heterotrimeric receptor that consists of the {beta} and {gamma} subunits of the IL-2 receptor (IL-2R) as well as a specific, high-affinity IL-15-binding subunit, which is designated IL-15R{alpha}. Since both the {beta} and the {gamma} subunits of the IL-2R are required for signaling by either IL-2 or IL-15, it is not surprising that these cytokines share many activities in vitro. However, the differential expression of these cytokines and the {alpha} chains of their receptors within various tissues and cell types suggests that IL-2 and IL-15 may perform at least partially distinct physiological functions. The production of IL-15 by macrophages, and possibly other cell types, in response to environmental stimuli and infectious agents suggests that IL-15 may play a role in protective immune responses, allograft rejection, and the pathogenesis of autoimmune diseases. 56 refs.

  11. IL

    Office of Legacy Management (LM)

    T1e rez;;' 3-' :s Of ain: dust soa.es fakxl dcrriq tile ;27- ,..:rc?ti:m (see TnbXe I) ... %EELE & SI' BBpI,'

  12. IL

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable Energy Future Stationary Power Energy Conversion Efficiency Solar Energy Wind Energy Water Power ...

  13. Structural and Biophysical Studies of the Human IL-7/IL-7R[alpha] Complex

    SciTech Connect

    McElroy, Craig A.; Dohm, Julie A.; Walsh, Scott T.R.; (OSU); (UPENN)

    2009-03-06

    IL-7 and IL-7R{alpha} bind the {gamma}{sub c} receptor, forming a complex crucial to several signaling cascades leading to the development and homeostasis of T and B cells. We report that the IL-7R{alpha} ectodomain uses glycosylation to modulate its binding constants to IL-7, unlike the other receptors in the {gamma}{sub c} family. IL-7 binds glycosylated IL-7R{alpha} 300-fold more tightly than unglycosylated IL-7R{alpha}, and the enhanced affinity is attributed primarily to an accelerated on rate. Structural comparison of IL-7 in complex to both forms of IL-7R{alpha} reveals that glycosylation does not participate directly in the binding interface. The SCID mutations of IL-7R{alpha} locate outside the binding interface with IL-7, suggesting that the expressed mutations cause protein folding defects in IL-7R{alpha}. The IL-7/IL-7R{alpha} structures provide a window into the molecular recognition events of the IL-7 signaling cascade and provide sites to target for designing new therapeutics to treat IL-7-related diseases.

  14. DOE - Office of Legacy Management -- Granite City IL Site - IL 28

    Office of Legacy Management (LM)

    Granite City IL Site - IL 28 FUSRAP Considered Sites Granite City, IL Alternate Name(s): Granite City Steel General Steel Industries General Steel Casings Corporation New Betatron Building IL.28-3 Location: 1417 State Street, Granite City, Illinois IL.28-3 Historical Operations: Under subcontract with Mallinckrodt and using a government-owned Betatron (magnetic induction electron accelerator), x-rayed natural uranium ingots and dingots to detect metallurgical flaws. Contamination from rubbing

  15. DOE - Office of Legacy Management -- Sciaky Brothers Inc - IL...

    Office of Legacy Management (LM)

    , Chicago , Illinois IL.0-06-1 Evaluation Year: 1987 IL.0-06-2 Site Operations: One time operation involving stitch welding of uranium in 1953. IL.0-06-1 IL.0-06-2 Site...

  16. DOE - Office of Legacy Management -- Madison - IL 26

    Office of Legacy Management (LM)

    Madison - IL 26 FUSRAP Considered Sites Madison, IL Alternate Name(s): Spectrulite Consortium, Inc. Former Dow Chemical Company Site IL.26-3 IL.26-4 Location: Intersection of College and Weaver Streets, Madison, Illinois IL.26-4 Historical Operations: Conducted experimental work in natural uranium metal extrusion. IL.26-4 IL.26-5 Eligibility Determination: Eligible IL.26-1 IL.26-2 Radiological Survey(s): Assessment Survey, Verification Survey IL.26-4 LTSM00011565 LTSM00013029 LTSM00011563 Site

  17. DOE - Office of Legacy Management -- Vapofier Corp - IL 25

    Office of Legacy Management (LM)

    Alternate Name: Therm-A-Shield Co. IL.25-1 Location: 11957 Vincennes Avenue , Blue Island , Illinois IL.25-2 Evaluation Year: 1990 IL.25-1 Site Operations: Vapofier...

  18. DOE - Office of Legacy Management -- Podbeilniac Corp - IL 22

    Office of Legacy Management (LM)

    Disposition: Eliminated - Potential for contamination considered remote due to limited scope of activities performed at the site IL.22-2 IL.22-3 IL.22-4 Radioactive Materials ...

  19. DOE - Office of Legacy Management -- Crane Co - IL 13

    Office of Legacy Management (LM)

    Crane Co - IL 13 FUSRAP Considered Sites Site: Crane Co. (IL.13 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Chicago ...

  20. Curcumin blocks interleukin (IL)-2 signaling in T-lymphocytes by inhibiting IL-2 synthesis, CD25 expression, and IL-2 receptor signaling

    SciTech Connect

    Forward, Nicholas A.; Conrad, David M.; Power Coombs, Melanie R.; Doucette, Carolyn D.; Furlong, Suzanne J.; Lin, Tong-Jun; Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia ; Hoskin, David W.

    2011-04-22

    Highlights: {yields} Curcumin inhibits CD4{sup +} T-lymphocyte proliferation. {yields} Curcumin inhibits interleukin-2 (IL-2) synthesis and CD25 expression by CD4{sup +} T-lymphocytes. {yields} Curcumin interferes with IL-2 receptor signaling by inhibiting JAK3 and STAT5 phosphorylation. {yields} IL-2-dependent regulatory T-lymphocyte function and Foxp3 expression is downregulated by curcumin. -- Abstract: Curcumin (diferulomethane) is the principal curcuminoid in the spice tumeric and a potent inhibitor of activation-induced T-lymphocyte proliferation; however, the molecular basis of this immunosuppressive effect has not been well studied. Here we show that micromolar concentrations of curcumin inhibited DNA synthesis by mouse CD4{sup +} T-lymphocytes, as well as interleukin-2 (IL-2) and CD25 ({alpha} chain of the high affinity IL-2 receptor) expression in response to antibody-mediated cross-linking of CD3 and CD28. Curcumin acted downstream of protein kinase C activation and intracellular Ca{sup 2+} release to inhibit I{kappa}B phosphorylation, which is required for nuclear translocation of the transcription factor NF{kappa}B. In addition, IL-2-dependent DNA synthesis by mouse CTLL-2 cells, but not constitutive CD25 expression, was impaired in the presence of curcumin, which demonstrated an inhibitory effect on IL-2 receptor (IL-2R) signaling. IL-2-induced phosphorylation of STAT5A and JAK3, but not JAK1, was diminished in the presence of curcumin, indicating inhibition of critical proximal events in IL-2R signaling. In line with the inhibitory action of curcumin on IL-2R signaling, pretreatment of CD4{sup +}CD25{sup +} regulatory T-cells with curcumin downregulated suppressor function, as well as forkhead box p3 (Foxp3) expression. We conclude that curcumin inhibits IL-2 signaling by reducing available IL-2 and high affinity IL-2R, as well as interfering with IL-2R signaling.

  1. DOE - Office of Legacy Management -- Morse Chemical Co - IL 0...

    Office of Legacy Management (LM)

    Morse Chemical Co - IL 0-05 FUSRAP Considered Sites Site: MORSE CHEMICAL CO. (IL.0-05 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: ...

  2. DOE - Office of Legacy Management -- Blockson Chemical Co - IL...

    Office of Legacy Management (LM)

    Blockson Chemical Co - IL 07 FUSRAP Considered Sites Site: Blockson Chemical Co. (IL.07) Eliminated from consideration under FUSRAP - Referred to US EPA Region V and the State of ...

  3. DOE - Office of Legacy Management -- Rock Island Arsenal - IL...

    Office of Legacy Management (LM)

    to DOD Designated Name: Not Designated Alternate Name: None Location: Rock Island , Illinois IL.09-1 Evaluation Year: 1987 IL.09-2 Site Operations: Site located on a DOD ...

  4. Secretary Bodman Highlights Advanced Energy Initiative in Peoria, IL |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Advanced Energy Initiative in Peoria, IL Secretary Bodman Highlights Advanced Energy Initiative in Peoria, IL April 6, 2006 - 10:15am Addthis PEORIA, IL - Secretary of Energy Samuel W. Bodman today highlighted the goals of President Bush's Advanced Energy Initiative after consulting on an energy savings assessment at Caterpillar Inc.'s manufacturing facility in Peoria, Illinois. To answer President Bush's call for Americans to be more energy efficient, the Department of

  5. DOE - Office of Legacy Management -- Kaiser Aluminum Corp - IL...

    Office of Legacy Management (LM)

    Disposition: Eliminated - Potential for contamination considered remote due to limited scope of activities IL.19-3 Radioactive Materials Handled: Yes Primary Radioactive Materials ...

  6. Intrathymic radioresistant stem cells follow an IL-2/IL-2R pathway during thymic regeneration after sublethal irradiation

    SciTech Connect

    Zuniga-Pfluecker, J.C.K.; Kruisbeek, A.M. )

    1990-05-15

    Sublethally irradiated mice undergo thymic regeneration which follows a phenotypic pattern of events similar to that observed during normal fetal development. Thymic regeneration after irradiation is the product of a limited pool of intrathymic radioresistant stem cells undergoing simultaneous differentiation. We show that in this model of T cell development, thymic regeneration follows a pathway in which the IL-2R is transiently expressed on CD4-/CD8- cells. IL-2R expression occurred during the exponential growth period of thymic regeneration, and IL-2R blocking prevented this explosive growth. Flow cytometry analysis revealed that the IL-2R blockade affected primarily the development of the immature CD3-/CD4-/CD8- (triple negative) cells and their ability to generate CD3+/CD4+/CD8+ or CD3+/CD4+/CD8- and CD3+/CD4-/CD8+ thymocytes. Thus, our findings demonstrate that blocking of the IL-2R resulted in an arrest in proliferation and differentiation by intrathymic radioresistant stem cells, indicating that the IL-2/IL-2R pathway is necessary for the expansion of immature triple negative T cells.

  7. DOE - Office of Legacy Management -- Heavy Minerals Inc - IL...

    Office of Legacy Management (LM)

    proposal to supply thorium hydroxide to the AEC; no indication that the bid was accepted. ... Primary Radioactive Materials Handled: Thorium IL.14-2 Radiological Survey(s): No Site ...

  8. DOE - Office of Legacy Management -- Chicago South IL Site -...

    Office of Legacy Management (LM)

    This site is managed by the U.S. Department of Energy Office of Legacy Management. IL.06-1 - DOE Memorandum; Coffman to LaGrone; Subject: Designation of the University of Chicago ...

  9. Climate Leadership Conference (Chicago, IL) | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Climate Leadership Conference (Chicago, IL) Climate Leadership Conference (Chicago, IL) March 1, 2017 9:00AM CST to March 3, 2017 3:30PM CST The annual Climate Leadership Conference convenes a global audience of climate, energy, and sustainability professionals to address climate change. Following the historic Paris agreement, last year's Climate Leadership Conference hosted the nation's sustainability leaders to further accelerate climate solutions and a low-carbon economy. Learn more

  10. Interleukin-2 (IL-2) dependent expression of biologically relevant IL-2 receptors: uncoupling of anti-T3 induced receptor expression with cyclosporin

    SciTech Connect

    Gitter, A.B.D.; Labus, J.M.; Butler, L.D.

    1986-03-01

    Human peripheral blood T cell expression of IL-2 receptors (IL-2R), detected by both immunocytofluorometry and /sup 125/I-IL-2 binding, was studied using lymphocytes stimulated with monoclonal anti-T3 antibodies (Leu-4, OKT3). Lymphocytes, isolated from healthy individuals, were prescreened and classified as Leu-4 responders or non-responders according to 72 h /sup 3/H-thymidine incorporation experiments. Leu-4 non-responder lymphocytes, though capable of normal IL-2R expression and IL-2 secretion when cultured with OKT3 (IgG2a), expressed little to no IL-2R nor secreted IL-2 when stimulated with Leu-4 (IgG1). In addition, the amount of IL-2 secreted by Leu-4 stimulated, Leu-4 responder cells, was one-third- to one-fifth of that detected when OKT3 was used as the stimulant. The addition of recombinant IL-2 (rIL-2) to a Leu-4 stimulated, Leu-4 non-responder lymphocyte culture, resulted in the expression of IL-2R and cellular proliferation, indicating that IL-2 upregulated its biologically relevant receptor. As expected, cyclosporin-A (CSA) inhibited the secretion of IL-2 and subsequent proliferation of Leu-4 stimulated, Leu-4 responder cells. Unexpectedly, however, the expression of IL-2R was also blocked. Exogenous rIL-2 partially reversed the effect of CSA on IL-2R expression and proliferation. The results indicate that IL-2 may provide an additional, required signal for optimal IL-2R expression.

  11. Acidic environment augments FcεRI-mediated production of IL-6 and IL-13 in mast cells

    SciTech Connect

    Kamide, Yosuke; Ishizuka, Tamotsu; Tobo, Masayuki; Tsurumaki, Hiroaki; Aoki, Haruka; Mogi, Chihiro; Nakakura, Takashi; Yatomi, Masakiyo; Ono, Akihiro; Koga, Yasuhiko; Sato, Koichi; Hisada, Takeshi; Dobashi, Kunio; Yamada, Masanobu; Okajima, Fumikazu

    2015-08-28

    Although blood pH is maintained in a narrow range of around pH 7.4 in living organisms, inflammatory loci are characterized by acidic conditions. Mast cells tend to reside close to the surface of the body in areas such as the mucosa and skin where they may be exposed to exogenous acids, and they play an important role in immune responses. However, little is known about the effects of extracellular acidification on the functions of mast cell. Here, we found that extracellular acidification increased the dinitrophenyl-conjugated human serum albumin (DNP-HSA)-induced production of interleukin (IL)-6 and IL-13 in MC/9 cells or bone marrow-derived mouse mast cells sensitized with anti-DNP IgE. Extracellular acidification also inhibited migration of MC/9 cells toward DNP-HSA. In addition, acidic pH stimulated antigen-induced activation of p38 mitogen-activated protein kinase (MAPK) and protein kinase B (Akt). These findings suggest that extracellular acidification augmented antigen/IgE-induced and FcεRI-mediated production of IL-6 and IL-13 in mast cells, and that this was associated with the enhancement of p38 MAPK and Akt activation. - Highlights: • Antigen-induced IL-6 and IL-13 production was augmented by acidic pH in mast cells. • Acidic pH-induced actions were associated with activation of p38 MAPK and Akt. • Inhibition of p38 MAPK and Akt attenuated cytokine responses to acidic pH. • Acidic pH effects are not attributable to actions of known proton-sensing GPCRs.

  12. DOE - Office of Legacy Management -- C-B Tool Products Co - IL...

    Office of Legacy Management (LM)

    C-B Tool Products Co - IL 31 FUSRAP Considered Sites Site: C-B Tool Products Co. (IL.31 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name:...

  13. DOE - Office of Legacy Management -- Hydroblast Corp - IL 0-03

    Office of Legacy Management (LM)

    Eliminated - Potential for contamination considered remote based on the limited scope of activities at the site IL.0-03-2 IL.0-03-3 Radioactive Materials Handled: Yes ...

  14. DOE ZERH Case Study: Evolutionary Home Builders, The Adaptation Home, Geneva, IL

    SciTech Connect

    none,

    2015-09-01

    Case study of a DOE 2015 Housing Innovation Award winning custom home in the cold climate that got a HERS 30 without PV, with 2x8 24” on center walls with blown fiberglass and 4” polysio rigid foam; basement with 2” XPS interior, 4” under slab, 4” exterior of foundation wall; vented attic with R-100 blown cellulose; wo air-to-air heat pumps SEER 14.1; HSPF 9.6; heat pump water heater.

  15. Association study of schizophrenia and IL-2 receptor {beta} chain gene

    SciTech Connect

    Nimgaonkar, V.L.; Yang, Z.W.; Zhang, X.R.; Brar, J.S.

    1995-10-09

    A case-control association study was conducted in Caucasian patients with schizophrenia (DSM-III-R, n = 42) and unaffected controls (n = 47) matched for ethnicity and area of residence. Serum interleukin-2 receptor (IL-2R) concentrations, as well as a dinucleotide repeat polymorphism in the IL-2RP chain gene, were examined in both groups. No significant differences in IL-2R concentrations or in the distribution of the polymorphism were noted. This study does not support an association between schizophrenia and the IL-2RP gene locus, contrary to the suggestive evidence from linkage analysis in multicase families. 17 refs., 2 tabs.

  16. Cell type-specific roles of Jak3 in IL-2-induced proliferative signal transduction

    SciTech Connect

    Fujii, Hodaka . E-mail: hodaka@med.nyu.edu

    2007-03-16

    Binding of interleukin-2 (IL-2) to its specific receptor induces activation of two members of Jak family protein tyrosine kinases, Jak1 and Jak3. An IL-2 receptor (IL-2R)-reconstituted NIH 3T3 fibroblast cell line proliferates in response to IL-2 only when hematopoietic lineage-specific Jak3 is ectopically expressed. However, the mechanism of Jak3-dependent proliferation in the fibroblast cell line is not known. Here, I showed that Jak3 expression is dispensable for IL-2-induced activation of Jak1 and Stat proteins and expression of nuclear proto-oncogenes in the IL-2R-reconstituted fibroblast cell line. Jak3 expression markedly enhanced these IL-2-induced signaling events. In contrast, Jak3 expression was essential for induction of cyclin genes involved in the G1-S transition. These data suggest a critical role of Jak3 in IL-2 signaling in the fibroblast cell line and may provide further insight into the cell type-specific mechanism of cytokine signaling.

  17. Irreversible inhibition of RANK expression as a possible mechanism for IL-3 inhibition of RANKL-induced osteoclastogenesis

    SciTech Connect

    Khapli, Shruti M.; Tomar, Geetanjali B.; Barhanpurkar, Amruta P.; Gupta, Navita; Yogesha, S.D.; Pote, Satish T.; Wani, Mohan R.

    2010-09-03

    Research highlights: {yields} IL-3 inhibits receptor activator of NF-{kappa}B ligand (RANKL)-induced osteoclastogenesis. {yields} IL-3 inhibits RANKL-induced JNK activation. {yields} IL-3 down-regulates expression of c-Fos and NFATc1 transcription factors. {yields} IL-3 down-regulates RANK expression posttranscriptionally and irreversibly. {yields} IL-3 inhibits in vivo RANK expression. -- Abstract: IL-3, a cytokine secreted by activated T lymphocytes, stimulates the proliferation, differentiation and survival of pluripotent hematopoietic stem cells. In this study, we investigated the mechanism of inhibitory action of IL-3 on osteoclast differentiation. We show here that IL-3 significantly inhibits receptor activator of NF-{kappa}B (RANK) ligand (RANKL)-induced activation of c-Jun N-terminal kinase (JNK). IL-3 down-regulates expression of c-Fos and nuclear factor of activated T cells (NFATc1) transcription factors. In addition, IL-3 down-regulates RANK expression posttranscriptionally in both purified osteoclast precursors and whole bone marrow cells. Furthermore, the inhibitory effect of IL-3 on RANK expression was irreversible. Interestingly, IL-3 inhibits in vivo RANK expression in mice. Thus, we provide the first evidence that IL-3 irreversibly inhibits RANK expression that results in inhibition of important signaling molecules induced by RANKL.

  18. File:USDA-CE-Production-GIFmaps-IL.pdf | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    IL.pdf Jump to: navigation, search File File history File usage Illinois Ethanol Plant Locations Size of this preview: 463 599 pixels. Other resolution: 464 600 pixels. Full...

  19. ORNLIRASA-S9Il9 HEALTH m SAFETY RESEARCH DMSION I Environmental...

    Office of Legacy Management (LM)

    S9Il9 HEALTH m SAFETY RESEARCH DMSION I Environmental Restoration and Waste hlanagement Non-Defense Programs (Activity No. EX 20 20 01 0; ADS317oooO) RESULTS OF THE RADIOLOGICAL ...

  20. DOE - Office of Legacy Management -- Eimco Corp - IL 0-01

    Office of Legacy Management (LM)

    on the limited scope of activities at the site IL.0-01-1 Radioactive Materials Handled: Yes Primary Radioactive Materials Handled: Test Quantities of Uranium (Yellow Cake Uranium). ...

  1. IL-33 inhibits RANKL-induced osteoclast formation through the regulation of Blimp-1 and IRF-8 expression

    SciTech Connect

    Kiyomiya, Hiroyasu; Ariyoshi, Wataru; Okinaga, Toshinori; Kaneuji, Takeshi; Mitsugi, Sho; Sakurai, Takuma; Habu, Manabu; Yoshioka, Izumi; Tominaga, Kazuhiro; and others

    2015-05-01

    Interleukin (IL)-33 is a recently discovered proinflammatory cytokine that belongs to the IL-1 family. Several studies have reported that IL-33 inhibits osteoclast differentiation. However, the mechanism of IL-33 regulation of osteoclastogenesis remains unclear. In the present study, we examined the effect of IL-33 on osteoclast formation in vitro. IL-33 suppressed osteoclast formation in both mouse bone marrow cells and monocyte/macrophage cell line RAW264.7 cells induced by receptor activator of NF-κB ligand (RANKL) and/or macrophage stimulating factor (M-CSF). IL-33 also inhibited the expression of RANKL-induced nuclear factor of activated T-cell cytoplasmic 1 (NFATc1), thereby decreasing the expression of osteoclastogenesis-related marker genes, including Cathepsin K, Osteoclast stimulatory transmembrane protein (Oc-stamp) and Tartrate-resistant acid phosphatase (Trap). Blockage of IL-33-ST2 binding suppressed the IL-33-mediated inhibition of NFATc1. RANKL-induced B-lymphocyte-induced maturation protein-1 (Blimp-1) expression was also suppressed by IL-33, which was followed by the stimulation of anti-osteoclastic genes such as interferon regulatory factor-8 (IRF-8). These results suggest that IL-33-ST2 interactions down-regulate both RANKL-induced NFATc1 activation and osteoclast differentiation via the regulation of Blimp-1 and IRF-8 expression. - Highlights: • IL-33 inhibits RANKL-induced osteoclast formation. • IL-33 has inhibitory effect on the RANKL-induced NFATc1 expression. • IL-33-induced NFATc1 suppression depends on the regulation of Blimp-1 and IRF-8.

  2. Secretary Chu Announces Agreement on FutureGen Project in Mattoon, IL |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Agreement on FutureGen Project in Mattoon, IL Secretary Chu Announces Agreement on FutureGen Project in Mattoon, IL June 12, 2009 - 12:00am Addthis Washington, D.C. - U.S. Secretary of Energy Steven Chu today announced an agreement with the FutureGen Alliance that advances the construction of the first commercial scale, fully integrated, carbon capture and sequestration project in the country in Mattoon, Illinois. "This important step forward for FutureGen reflects

  3. DOE Zero Energy Ready Home Case Study: Weiss Building & Development LLC., Custom Home, Downers Grove, IL

    Energy.gov [DOE]

    Case study of a DOE Zero Energy Ready Home in Downers Grove, IL, that scored HERS 35 without PV. This 3,600-square-foot custom home has advanced framed walls with R-23 dense-packed fiberglass plus R-13 rigid polyiso, a sealed attic with open-cell spray foam, a pier foundation, and 95% efficient gas furnace.

  4. IL.26

    Office of Legacy Management (LM)

    ... of beam dust samples in Building 6 (former Dow Chemical Company site) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 11 Location of overhead beam dust contam ...

  5. DOE Zero Energy Ready Home Case Study: StreetScape Development, LLC, Libertyville, IL, Custom

    Energy.gov [DOE]

    Case study of a DOE Zero Energy Ready Home in Libertyville, IL, that scored HERS 45 without PV. This 2,763-square-foot custom home has advanced framed walls with R-20 of open-cell spray foam, R-49 open-cell spray-foam sealed attic, an HRV, and a tankless water heater for hydro coil furnace with high-velocity, small-diameter ducts.

  6. Demonstration Assessment of Light-Emitting Diode (LED) Accent Lighting at the Field Museum in Chicago, IL

    SciTech Connect

    Myer, Michael; Kinzey, Bruce R.

    2010-12-10

    This report reviews a demonstration of light-emitting diode (LED) accent lighting compared to halogen (typical) accent lighting in a gallery of the Field Museum in Chicago, IL.

  7. Delivery of human NKG2D-IL-15 fusion gene by chitosan nanoparticles to enhance antitumor immunity

    SciTech Connect

    Yan, Chen; Jie, Leng; Yongqi, Wang; Weiming, Xiao; Juqun, Xi; Yanbing, Ding; Li, Qian; Xingyuan, Pan; Mingchun, Ji; Weijuan, Gong

    2015-07-31

    Nanoparticles are becoming promising carriers for gene delivery because of their high capacity in gene loading and low cell cytotoxicity. In this study, a chitosan-based nanoparticle encapsulated within a recombinant pcDNA3.1-dsNKG2D-IL-15 plasmid was generated. The fused dsNKG2D-IL-15 gene fragment consisted of double extracellular domains of NKG2D with IL-15 gene at downstream. The average diameter of the gene nanoparticles ranged from 200 nm to 400 nm, with mean zeta potential value of 53.8 ± 6.56 mV. The nanoparticles which were loaded with the dsNKG2D-IL-15 gene were uptaken by tumor cells with low cytotoxicity. Tumor cells pre-transfected by gene nanopartilces stimulated NK and T cells in vitro. Intramuscular injection of gene nanoparticles suppressed tumor growth and prolonged survival of tumor-bearing mice through activation of NK and CD8{sup +} T cells. Thus, chitosan-based nanoparticle delivery of dsNKG2D-IL-15 gene vaccine can be potentially used for tumor therapy. - Highlights: • Generation of a nanoparticle for delivery of dsNKG2D-IL-15 gene. • Characterization of the gene nanoparticle. • Antitumor activity mediated by the gene nanoparticle.

  8. Il,R!:i'iT[ WORKING GROUP Final Report of the Oak Ridge Reservation

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Il,R!:i'iT[ WORKING GROUP Final Report of the Oak Ridge Reservation End Use Working Group July, 1998 This report was written and edited by the members of the End Use Working Group with the assistance of Phoenix Environmental Corporation of Alexandria, Virginia. Additional copies and information can be found on the DOE Oak Ridge Operations site on the world wide web: ornl.gov/doe~oro/em/emhome.html or by calling the Information Resource Center at 423-241-4582. Final Report of the End Use Working

  9. Keratinocyte-derived IL-24 plays a role in the positive feedback regulation of epidermal inflammation in response to environmental and endogenous toxic stressors

    SciTech Connect

    Jin, Sun Hee; Choi, Dalwoong; Chun, Young-Jin; Noh, Minsoo

    2014-10-15

    Keratinocytes are the major cellular components of human epidermis and play a key role in the modulating cutaneous inflammation and toxic responses. In human chronic skin diseases, the common skin inflammatory phenotypes like skin barrier disruption and epidermal hyperplasia are manifested in epidermal keratinocytes by interactions with T helper (Th) cells. To find a common gene expression signature of human keratinocytes in chronic skin diseases, we performed a whole genome microarray analysis on normal human epidermal keratinocytes (NHKs) treated with IFNγ, IL-4, IL-17A or IL-22, major cytokines from Th1, Th2, Th17 or Th22 cells, respectively. The microarray results showed that the four genes, IL-24, PDZK1IP1, H19 and filaggrin, had common expression profiles in NHKs exposed to Th cell cytokines. In addition, the acute phase pro-inflammatory cytokines, IL-1β, IL-6 and TNFα, also change the gene transcriptional profile of IL-24, PDZK1IP1, H19, and filaggrin in NHKs as those of Th cytokines. Therefore, the signature gene set, consisting of IL-24, PDZK1IP1, H19, and filaggrin, provides essential insights for understanding the process of cutaneous inflammation and toxic responses. We demonstrate that environmental toxic stressors, such as chemical irritants and ultraviolet irradiation stimulate the production of IL-24 in NHKs. IL-24 stimulates the JAK1-STAT3 and MAPK pathways in NHKs, and promotes the secretion of pro-inflammatory mediators IL-8, PGE2, and MMP-1. These results suggest that keratinocyte-derived IL-24 participates in the positive feedback regulation of epidermal inflammation in response to both endogenous and environmental toxic stressors. - Highlights: • Cutaneous inflammatory gene signature consists of PDZK1IP1, IL-24, H19 and filaggrin. • Pro-inflammatory cytokines increase IL-24 production in human keratinocytes. • Environmental toxic stressors increase IL-24 production in human keratinocytes. • IL-24 stimulates human keratinocytes to

  10. IL1{beta}-mediated Stromal COX-2 signaling mediates proliferation and invasiveness of colonic epithelial cancer cells

    SciTech Connect

    Zhu, Yingting; Tissue Tech Inc, Miami, FL 33173 ; Zhu, Min; Lance, Peter

    2012-11-15

    COX-2 is a major inflammatory mediator implicated in colorectal inflammation and cancer. However, the exact origin and role of COX-2 on colorectal inflammation and carcinogenesis are still not well defined. Recently, we reported that COX-2 and iNOS signalings interact in colonic CCD18Co fibroblasts. In this article, we investigated whether activation of COX-2 signaling by IL1{beta} in primary colonic fibroblasts obtained from normal and cancer patients play a critical role in regulation of proliferation and invasiveness of human colonic epithelial cancer cells. Our results demonstrated that COX-2 level was significantly higher in cancer associated fibroblasts than that in normal fibroblasts with or without stimulation of IL-1{beta}, a powerful stimulator of COX-2. Using in vitro assays for estimating proliferative and invasive potential, we discovered that the proliferation and invasiveness of the epithelial cancer cells were much greater when the cells were co-cultured with cancer associated fibroblasts than with normal fibroblasts, with or without stimulation of IL1{beta}. Further analysis indicated that the major COX-2 product, prostaglandin E{sub 2}, directly enhanced proliferation and invasiveness of the epithelial cancer cells in the absence of fibroblasts. Moreover, a selective COX-2 inhibitor, NS-398, blocked the proliferative and invasive effect of both normal and cancer associate fibroblasts on the epithelial cancer cells, with or without stimulation of IL-1{beta}. Those results indicate that activation of COX-2 signaling in the fibroblasts plays a major role in promoting proliferation and invasiveness of the epithelial cancer cells. In this process, PKC is involved in the activation of COX-2 signaling induced by IL-1{beta} in the fibroblasts.

  11. Expression of low-, intermediate-, and high-affinity IL-2 receptors on B cell lines derived from patients with undifferentiated lymphoma of Burkitt's and non-Burkitt's types

    SciTech Connect

    Benjamin, D.; Rosolen, A.; Wormsley, S.B.; DeBault, L.E.; Colamonici, O.R. )

    1990-08-01

    IL-2 receptors on T cells exist in at least three forms which differ in their ligand-binding affinity. The low-affinity IL-2 receptor (IL-2R) consists of the 55-kDa Tac protein (p55 alpha), the intermediate-affinity site corresponds to the 70-kDa molecule (p70 beta), and the high-affinity IL-2R consists of a noncovalent heterodimeric structure involving both p55 alpha and p70 beta. We studied 24 B cell lines (8 EBV-negative and 16 EBV-positive) for IL-2R expression in the presence or absence of the tumor promoter, teleocidin. 125I-IL-2 radioreceptor binding assays and crosslinking studies demonstrated the sole expression of p55 alpha in EBV-negative cell lines only, whereas p55 alpha present in EBV-positive cell lines was always associated with p70 beta to construct high-affinity IL-2R. p70 beta was not detected in any of the EBV-negative cell lines, but was expressed on most of the EBV-positive cell lines (13 of 16). Our data also indicate that the expression of p55 alpha and p70 beta by radiolabeling correlates with their expression in flow cytometry, and that a large excess of p55 alpha is required to construct high-affinity IL-2R. Coexpression of p55 alpha and p70 beta on human B cells contributed to constructing high-affinity IL-2R hybrid complex as shown by rapid association rate contributed by p55 alpha and slow dissociation rate by p70 beta; teleocidin's ability to induce p55 alpha on cell lines which express p70 beta only, resulting in appearance of high-affinity IL-2R; and blocking p55 alpha by anti-Tac mAb in cell lines which constitutively express high-affinity IL-2R eliminated both high- and low-affinity components. The existence of low, intermediate, and high IL-2R on human B cells bears important future implications for understanding the mechanism of IL-2 signaling and the role of IL-2 in B cell activation, proliferation, and differentiation.

  12. Eu3+ as a dual probe for the determination of IL anion donor power: A combined luminescence spectroscopic and electrochemical approach

    SciTech Connect

    Babai, Arash; Kopiec, Gabriel; Lackmann, Anastasia; Mallick, Bert; Pitula, Slawomir; Tang, Sifu; Mudring, Anja-Verena

    2014-04-01

    This work is aimed at giving proof that Eu(Tf2N)(3) (Tf2N = bis(trifluoromethanesulfonyl)amide) can act as both an optical and electrochemical probe for the determination of the Lewis acidity of an ionic liquid anion. For that reason the luminescence spectra and cyclic voltammograms of dilute solutions of Eu(Tf2N)(3) in various ionic liquids were investigated. The Eu2+/3+ redox potential in the investigated ILs can be related to the Lewis basicity of the IL anion. The IL cation had little influence. The lower the determined halfwave potential, the higher the IL anion basicity. The obtained ranking can be confirmed by luminescence spectroscopy where a bathochromic shift of the D-5(0) -> F-7(4) transition indicates a stronger Lewis basicity of the IL anion. (C) 2014 Published by Elsevier B.V.

  13. Structure of the unique SEFIR domain from human interleukin 17 receptor A reveals a composite ligand-binding site containing a conserved α-helix for Act1 binding and IL-17 signaling

    SciTech Connect

    Zhang, Bing; Liu, Caini; Qian, Wen; Han, Yue; Li, Xiaoxia; Deng, Junpeng

    2014-05-01

    Crystal structure of the SEFIR domain from human IL-17 receptor A provides new insights into IL-17 signaling. Interleukin 17 (IL-17) cytokines play a crucial role in mediating inflammatory and autoimmune diseases. A unique intracellular signaling domain termed SEFIR is found within all IL-17 receptors (IL-17Rs) as well as the key adaptor protein Act1. SEFIR-mediated protein–protein interaction is a crucial step in IL-17 cytokine signaling. Here, the 2.3 Å resolution crystal structure of the SEFIR domain of IL-17RA, the most commonly shared receptor for IL-17 cytokine signaling, is reported. The structure includes the complete SEFIR domain and an additional α-helical C-terminal extension, which pack tightly together to form a compact unit. Structural comparison between the SEFIR domains of IL-17RA and IL-17RB reveals substantial differences in protein topology and folding. The uniquely long insertion between strand βC and helix αC in IL-17RA SEFIR is mostly well ordered, displaying a helix (αCC′{sub ins}) and a flexible loop (CC′). The DD′ loop in the IL-17RA SEFIR structure is much shorter; it rotates nearly 90° with respect to the counterpart in the IL-17RB SEFIR structure and shifts about 12 Å to accommodate the αCC′{sub ins} helix without forming any knots. Helix αC was identified as critical for its interaction with Act1 and IL-17-stimulated gene expression. The data suggest that the heterotypic SEFIR–SEFIR association via helix αC is a conserved and signature mechanism specific for IL-17 signaling. The structure also suggests that the downstream motif of IL-17RA SEFIR together with helix αC could provide a composite ligand-binding surface for recruiting Act1 during IL-17 signaling.

  14. Single high-dose irradiation aggravates eosinophil-mediated fibrosis through IL-33 secreted from impaired vessels in the skin compared to fractionated irradiation

    SciTech Connect

    Lee, Eun-Jung; Kim, Jun Won; Yoo, Hyun; Kwak, Woori; Choi, Won Hoon; Cho, Seoae; Choi, Yu Jeong; Lee, Yoon-Jin; Cho, Jaeho

    2015-08-14

    We have revealed in a porcine skin injury model that eosinophil recruitment was dose-dependently enhanced by a single high-dose irradiation. In this study, we investigated the underlying mechanism of eosinophil-associated skin fibrosis and the effect of high-dose-per-fraction radiation. The dorsal skin of a mini-pig was divided into two sections containing 4-cm{sup 2} fields that were irradiated with 30 Gy in a single fraction or 5 fractions and biopsied regularly over 14 weeks. Eosinophil-related Th2 cytokines such as interleukin (IL)-4, IL-5, and C–C motif chemokine-11 (CCL11/eotaxin) were evaluated by quantitative real-time PCR. RNA-sequencing using 30 Gy-irradiated mouse skin and functional assays in a co-culture system of THP-1 and irradiated-human umbilical vein endothelial cells (HUVECs) were performed to investigate the mechanism of eosinophil-mediated radiation fibrosis. Single high-dose-per-fraction irradiation caused pronounced eosinophil accumulation, increased profibrotic factors collagen and transforming growth factor-β, enhanced production of eosinophil-related cytokines including IL-4, IL-5, CCL11, IL-13, and IL-33, and reduced vessels compared with 5-fraction irradiation. IL-33 notably increased in pig and mouse skin vessels after single high-dose irradiation of 30 Gy, as well as in irradiated HUVECs following 12 Gy. Blocking IL-33 suppressed the migration ability of THP-1 cells and cytokine secretion in a co-culture system of THP-1 cells and irradiated HUVECs. Hence, high-dose-per-fraction irradiation appears to enhance eosinophil-mediated fibrotic responses, and IL-33 may be a key molecule operating in eosinophil-mediated fibrosis in high-dose-per fraction irradiated skin. - Highlights: • Single high-dose irradiation aggravates eosinophil-mediated fibrosis through IL-33. • Vascular endothelial cells damaged by high-dose radiation secrete IL-33. • Blocking IL-33 suppressed migration of inflammatory cells and cytokine secretion. • IL

  15. ENVIRONMENTAL IlONITORING REPORT FOR THE NEVADA TEST SITE AND OTHER TEST AREAS USED FOR UNDERGROUND NUCLEAR DETONATIONS

    Office of Legacy Management (LM)

    IlONITORING REPORT FOR THE NEVADA TEST SITE AND OTHER TEST AREAS USED FOR UNDERGROUND NUCLEAR DETONATIONS January through December 1975 Nonitoring Operations Division Environmental Monitoring and Support Laboratory U.S. ENVIRONMENTAL PROTECTION AGENCY Las Vegas, Nevada 89114 APRIL 1976 This work performed under a Memorandum of Understanding No. AT(26-1)-539 for the U . S . ENERGY RESEARCH & DEVELOPMENT ADMINISTRATION EMSL-LV-5 39-4 May 1976 ENVIRONMENTAL 14ONITORING REPORT FOR THE NEVADA

  16. Facile fabrication of rutile monolayer films consisting of well crystalline nanorods by following an IL-assisted hydrothermal route

    SciTech Connect

    Peng Peng; Liu Xiaodi; Sun, Chuansheng; Ma Jianmin; Zheng Wenjun

    2009-05-15

    In this study, rutile films consisting of rectangular nanorods were facilely deposited on glass substrates from strongly acid solution of TiCl{sub 4}. The highly ordered array of nanorods was realized in presence of ionic liquid (IL) of [Bmim]Br by following a hydrothermal process. In this process, Degussa P25 nanoparticles served as seeds that were pre-deposited on the substrates to facilitate the array of rutile nanorods. X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and Raman spectrum were used to characterize the obtained nanorod films. The measurements showed that the nanorods were rectangular with width of 100-200 nm and length of more than 1 {mu}m, and grew up typically along c-axis to form the arrays against the substrate. The presence of IL was found vital for the formation of rutile nanorods, and the suitable molar ratio of [Bmim]Br to TiCl{sub 4} ranged from 500:1 to 1500:1. The excessive [Bmim]Br may hinder the precipitation of rutile particles. - Graphical abstract: The rutile film consisting of rectangular nanorods is successfully deposited on glass substrate in presence of ionic liquid (IL) of [Bmim]Br. The nanorods were rectangular with width of 100-200 nm and length of more than 1 {mu}m, which grew up typically along c-axis to form the arrays against the substrate.

  17. IL-2R{gamma} gene microdeletion demonstrates that canine X-linked severe combined immunodeficiency is a homologue of the human disease

    SciTech Connect

    Henthorn, P.S.; Fimiani, V.M.; Patterson, D.F.

    1994-09-01

    X-linked severe combined immunodeficiency (SCID) is characterized by profound defects in cellular and humoral immunity and, in humans, is associated with mutations in the gene for the {gamma} chain of the IL-2 receptor (IL-2R{gamma}). We have examined this gene in a colony of dogs established from a single X-linked SCID carrier female. Affected dogs have a 4-bp deletion in the first exon of the IL-2R{gamma} gene, which precludes the production of a functional protein, demonstrating that the canine disease is a true homologue of human X-linked SCID. 37 refs., 3 figs.

  18. HIA 2015 DOE Zero Energy Ready Home Case Study: BrightLeaf Homes, McCormick Avenue, Brookfield, IL

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    BrightLeaf Homes McCormick Avenue Brookfield, IL DOE ZERO ENERGY READY HOME(tm) The U.S. Department of Energy invites home builders across the country to meet the extraordinary levels of excellence and quality specified in DOE's Zero Energy Ready Home program (formerly known as Challenge Home). Every DOE Zero Energy Ready Home starts with ENERGY STAR Certified Homes Version 3.0 for an energy-efficient home built on a solid foundation of building science research. Advanced technologies are

  19. Activation of IL-2 receptor {alpha}-chain gene by individual members of the rel oncogene family in association with serum response factor

    SciTech Connect

    Pierce, J.W.; Jamieson, C.A.; Ross, J.L.

    1995-08-15

    Expression of the IL-2R{alpha} gene is regulated by members of the c-Rel/NF-{kappa}B family of transcription factors binding to the {kappa}B site in the promoter. Previous work has not defined the role of individual members of the c-Rel family in the activation of the IL-2R{alpha} gene. Using the COS cell system, we were able to reconstitute the regulation of the IL-2R{alpha} promoter by expressing cloned Rel family members with serum response factor (SRF). We found that c-rel alone activated the IL-2R{alpha} promoter only weakly but worked with the p50 subunit of NF-{kappa}B (NFKB1) to give a higher level of expression. We showed that c-rel heterodimerizes with p50 and the amount of this heterodimer correlated with the level of IL-2R{alpha} gene expression. Our results provide evidence that c-rel/p50 heterodimers activate gene expression in the context of a cellular promoter. We show that c-rel or p65 can cooperate with SRF in the activation of this promoter and the transactivation by c-rel with SRF was enhanced by p50. Synergistic activation required both {kappa}B an CArG sites, and binding studies show that these that these adjacent sites can be occupied simultaneously. The transactivation observed with cloned transcription factors mimics the physiologic induction of the IL-2R{alpha} gene since multiple sequence elements cooperate to give gene activation. The data support the model that c-rel/p50 or p65 can cooperate with SRF to specifically target the expression of the IL-2R{alpha} gene in activated T cells.

  20. Immunosuppressive effect of the anti-IL-2-receptor monoclonal antibody, AMT-13, on organ-cultured fetal pancreas allograft survival

    SciTech Connect

    Burkhardt, K.; Loughnan, M.S.; Diamantstein, T.; Mandel, T.E.

    1988-11-01

    Recently, prolongation of cardiac allograft survival in mice was reported using a rat anti-IL-2R mAb (AMT-13). However, its immunosuppressive action in vivo, alone and in combination with other immunosuppressants, and its effect on other organ transplants has not been extensively studied. We grafted cultured fetal pancreas from CBA (H-2k) donors to Balb/c (H-2d) mice. Recipients were treated with 10 consecutive daily injections each of 20 micrograms AMT-13 only, or with an additional mild immunosuppression of 350 rads irradiation. Control groups received rat immunoglobulin or 350 rads irradiation. Graft survival and the phenotype of infiltrating cells were assessed histologically and immunocytochemically on days 12, 17, and 21, and soluble IL-2R levels were measured in the serum with a quantitative ELISA in all recipients. Two of five grafts in the AMT-13-treated group had islets on day 12 posttransplantation despite lymphocytic infiltration in all grafts, while at this time all grafts of rat Ig treated control mice were completely rejected with only scar tissue and a few lymphocytes remaining. Additional immunosuppression with 350 rads irradiation had a marked additive effect with AMT-13. Soluble IL-2R levels in the serum of untreated recipients were not elevated compared with normal serum levels, but recipients injected with AMT-13 had multifold increased soluble IL-2R levels. The percentage of IL-2R+ cells in the grafts of AMT-13-treated animals was either normal (less than 5%) or increased (20%) in the additionally irradiated mice, providing strong evidence that the immunosuppressive effect of AMT-13 is not due to a depletion of activated IL-2R+ lymphocytes.

  1. Thermal spray removal of lead-based paint from the viaduct bridge at Rock Island Arsenal, IL. Final report

    SciTech Connect

    Boy, J.H.; Weber, R.A.; Kumar, A.

    1998-06-01

    This report documents a field demonstration at the Rock Island Arsenal, IL, that validated the thermal spray vitrification (TSV) process as a safe and effective technique for removing lead-based paint from a steel bridge. Specially formulated glass was applied in a molten state to painted steel using a conventional thermal spray application system. The molten glass reacts with the paint, and encapsulates the lead. The cooled glass readily cracks and falls off, removing the paint. After onsite remelting of the glass waste to complete the encapsulation process, the final waste product is chemically inert and may be disposed of in a regular landfill. The Illinois Environmental Protection Agency, Division of Air Pollution Control determined that the glass remelt process could be considered a paint-removal operation for which no air quality permit was required.

  2. ROS and NF-{kappa}B are involved in upregulation of IL-8 in A549 cells exposed to multi-walled carbon nanotubes

    SciTech Connect

    Ye Shefang Wu Yihui; Hou Zhenqing; Zhang Qiqing

    2009-02-06

    Carbon nanotubes (CNTs) have potential applications in biosensors, tissue engineering, and biomedical devices because of their unique physico-chemical, electronic and mechanical properties. However, there is limited literature data available concerning the biological properties and toxicity of CNTs. This study aimed to assess the toxicity exhibited by multi-walled CNTs (MWCNTs) and to elucidate possible molecular mechanisms underlying the biological effects of MWCNTs in A549 cells. Exposing A549 cells to MWCNTs led to cell death, changes in cell size and complexity, reactive oxygen species (ROS) production, interleukin-8 (IL-8) gene expression and nuclear factor (NF)-{kappa}B activation. Treatment of A549 cells with antioxidants prior to adding MWCNTs decreased ROS production and abrogated expression of IL-8 mRNA. Pretreatment of A549 cells with NF-{kappa}B inhibitors suppressed MWCNTs-induced IL-8 mRNA expression. These results indicate that MWCNTs are able to induce expression of IL-8 in A549 cells, at least in part, mediated by oxidative stress and NF-{kappa}B activation.

  3. Arsenite evokes IL-6 secretion, autocrine regulation of STAT3 signaling, and miR-21 expression, processes involved in the EMT and malignant transformation of human bronchial epithelial cells

    SciTech Connect

    Luo, Fei; Xu, Yuan; Ling, Min; Zhao, Yue; Xu, Wenchao; Liang, Xiao; Jiang, Rongrong; Wang, Bairu; Bian, Qian; Liu, Qizhan

    2013-11-15

    Arsenite is an established human carcinogen, and arsenite-induced inflammation contributes to malignant transformation of cells, but the molecular mechanisms by which cancers are produced remain to be established. The present results showed that, evoked by arsenite, secretion of interleukin-6 (IL-6), a pro-inflammatory cytokine, led to the activation of STAT3, a transcription activator, and to increased levels of a microRNA, miR-21. Blocking IL-6 with anti-IL-6 antibody and inhibiting STAT3 activation reduced miR-21 expression. For human bronchial epithelial cells, cultured in the presence of anti-IL-6 antibody for 3 days, the arsenite-induced EMT and malignant transformation were reversed. Thus, IL-6, acting on STAT3 signaling, which up-regulates miR-21in an autocrine manner, contributes to the EMT induced by arsenite. These data define a link from inflammation to EMT in the arsenite-induced malignant transformation of HBE cells. This link, mediated through miRNAs, establishes a mechanism for arsenite-induced lung carcinogenesis. - Highlights: Arsenite evokes IL-6 secretion. IL-6 autocrine mediates STAT3 signaling and up-regulates miR-21expression. Inflammation is involved in arsenite-induced EMT.

  4. Geneva Steel blast furnace improvements

    SciTech Connect

    Fowles, R.D.; Hills, L.S.

    1993-01-01

    Geneva Steel is located in Utah and is situated near the western edge of the Rocky Mountains adjacent to the Wasatch Front. Geneva's No. 1, 2 and 3 are the only remaining operating blast furnaces in the United States west of the Mississippi River. They were originally constructed in 1943 to support steelmaking during World War II. During the early 60's all three furnaces were enlarged to their current working volume. Very few major improvements were made until recently. This discussion includes a brief historical perspective of operating difficulties associated with practice, design and equipment deficiencies. Also included is an overview of blast furnace improvements at Geneva found necessary to meet the demands of modern steelmaking. Particular emphasis will be placed on casthouse improvements.

  5. Il.-'",.'

    Office of Legacy Management (LM)

    ,,.. .r' +p,o~ ,!,*' A;>$, :.::> ,' ; ,.;I:- : ~ ", ,r .,,. ' , ' i.,l<, ~ ,1* .iT ,.~~~~~~~I~ _,L :,~.:/: .,,.,,,.,' ,, ;, ,, ,, I .. ,(: _ : ; . , y.,+ lar&f&r!rj&~+ ,id) L"'w#~~~~* I. ,& f ;";.y,m; ,I @ & *<7r;,q* >*t&,y%:iis ;*a k' q&t ,:.: ;,I,' ,,, ,_ *, . ,. ,,&S_ ;, , (, t+ I . 1. -. ' ,' ~' i"'i,!..l + *I .(, h," ,rz ,. ,' :' ,' . :,' . ,.' _-#I_ ,. ,I. :, ,.' , ..I>. Xi,,? ,I. , ,r c/i' ,"" >.:1..

  6. AIR M A IL

    Office of Legacy Management (LM)

    A three biscuit charge will, when molten, fill the proposed crucible half full. This condition is un- desirable because, due to the low heat of fusion of thorium and the ...

  7. DOE Zero Energy Ready Home Case Study: Evolutionary Home Builders...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Evolutionary Home Builders, The Adaptation Home, Geneva, IL DOE Zero Energy Ready Home Case Study: Evolutionary Home Builders, The Adaptation Home, Geneva, IL DOE Zero Energy Ready ...

  8. Celecoxib offsets the negative renal influences of cyclosporine via modulation of the TGF-?1/IL-2/COX-2/endothelin ET{sub B} receptor cascade

    SciTech Connect

    El-Gowelli, Hanan M.; Helmy, Maged W.; Ali, Rabab M.; El-Mas, Mahmoud M.

    2014-03-01

    Endothelin (ET) signaling provokes nephrotoxicity induced by the immunosuppressant drug cyclosporine A (CSA). We tested the hypotheses that (i): celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, counterbalances renal derangements caused by CSA in rats and (ii) the COX-2/endothelin ET{sub B} receptor signaling mediates the CSA-celecoxib interaction. Ten-day treatment with CSA (20 mg/kg/day) significantly increased biochemical indices of renal function (serum urea, creatinine), inflammation (interleukin-2, IL-2) and fibrosis (transforming growth factor-?{sub 1}, TGF-?{sub 1}). Histologically, CSA caused renal tubular atrophy along with interstitial fibrosis. These detrimental renal effects of CSA were largely reduced in rats treated concurrently with celecoxib (10 mg/kg/day). We also report that cortical glomerular and medullary tubular protein expressions of COX-2 and ET{sub B} receptors were reduced by CSA and restored to near-control values in rats treated simultaneously with celecoxib. The importance of ET{sub B} receptors in renal control and in the CSA-celecoxib interaction was further verified by the findings (i) most of the adverse biochemical, inflammatory, and histopathological profiles of CSA were replicated in rats treated with the endothelin ET{sub B} receptor antagonist BQ788 (0.1 mg/kg/day, 10 days), and (ii) the BQ788 effects, like those of CSA, were alleviated in rats treated concurrently with celecoxib. Together, the data suggest that the facilitation of the interplay between the TGF-?1/IL-2/COX-2 pathway and the endothelin ET{sub B} receptors constitutes the cellular mechanism by which celecoxib ameliorates the nephrotoxic manifestations of CSA in rats. - Highlights: Celecoxib abolishes nephrotoxic manifestations of CSA in rats. Blockade of ETB receptors by BQ788 mimicked the nephrotoxic effects of CSA. CSA or BQ788 reduces renal protein expression of COX-2 and endothelin ETB receptors. Enhanced TGF?1/IL-2/COX2/ETB signaling

  9. Geneva County, Alabama: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Geneva, Alabama Hartford, Alabama Malvern, Alabama Samson, Alabama Slocomb, Alabama Taylor, Alabama Retrieved from "http:en.openei.orgwindex.php?titleGenevaCounty,Alabama...

  10. Geneva, Indiana: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Map This article is a stub. You can help OpenEI by expanding it. Geneva is a town in Adams County, Indiana. It falls under Indiana's 6th congressional district.12 References...

  11. TGF-{beta}1 increases invasiveness of SW1990 cells through Rac1/ROS/NF-{kappa}B/IL-6/MMP-2

    SciTech Connect

    Binker, Marcelo G.; CBRHC Research Center, Buenos Aires ; Binker-Cosen, Andres A.; Gaisano, Herbert Y.; Cosen, Rodica H. de; Cosen-Binker, Laura I.

    2011-02-04

    Research highlights: {yields} Rac1 mediates TGF-{beta}1-induced SW1990 invasion through MMP-2 secretion and activation. {yields} NADPH-generated ROS act downstream of Rac1 in TGF-{beta}1-challenged SW1990 cells. {yields} TGF-{beta}1-stimulated ROS activate NF-{kappa}B in SW1990 cells. {yields} NF{kappa}B-induced IL-6 release is required for secretion and activation of MMP-2 in SW1990 cells. -- Abstract: Human pancreatic cancer invasion and metastasis have been found to correlate with increased levels of active matrix metalloproteinase 2 (MMP-2). The multifunctional cytokine transforming growth factor beta 1 (TGF-{beta}1) has been shown to increase both secretion of MMP-2 and invasion by several pancreatic cancer cell types. In the present study, we investigated the signaling pathway involved in TGF-{beta}1-promoted MMP-2 secretion and invasion by human pancreatic cancer cells SW1990. Using specific inhibitors, we found that stimulation of these tumor cells with TGF-{beta}1 induced secretion and activation of the collagenase MMP-2, which was required for TGF-{beta}1-stimulated invasion. Our results also indicate that signaling events involved in TGF-{beta}1-enhanced SW1990 invasiveness comprehend activation of Rac1 followed by generation of reactive oxygen species through nicotinamide adenine dinucleotide phosphate-oxidase, activation of nuclear factor-kappa beta, release of interleukin-6, and secretion and activation of MMP-2.

  12. Zinc ferrite nanoparticles activate IL-1b, NFKB1, CCL21 and NOS2 signaling to induce mitochondrial dependent intrinsic apoptotic pathway in WISH cells

    SciTech Connect

    Saquib, Quaiser; Al-Khedhairy, Abdulaziz A.; Ahmad, Javed; Siddiqui, Maqsood A.; Dwivedi, Sourabh; Khan, Shams T.; Musarrat, Javed

    2013-12-01

    The present study has demonstrated the translocation of zinc ferrite nanoparticles (ZnFe{sub 2}O{sub 4}-NPs) into the cytoplasm of human amnion epithelial (WISH) cells, and the ensuing cytotoxicity and genetic damage. The results suggested that in situ NPs induced oxidative stress, alterations in cellular membrane and DNA strand breaks. The [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT) and neutral red uptake (NRU) cytotoxicity assays indicated 64.48 1.6% and 50.73 2.1% reduction in cell viability with 100 ?g/ml of ZnFe{sub 2}O{sub 4}-NPs exposure. The treated WISH cells exhibited 1.2-fold higher ROS level with 0.9-fold decline in membrane potential (??m) and 7.4-fold higher DNA damage after 48 h of ZnFe{sub 2}O{sub 4}-NPs treatment. Real-time PCR (qPCR) analysis of p53, CASP 3 (caspase-3), and bax genes revealed 5.3, 1.6, and 14.9-fold upregulation, and 0.18-fold down regulation of bcl 2 gene vis--vis untreated control. RT{sup 2} Profiler PCR array data elucidated differential up-regulation of mRNA transcripts of IL-1b, NFKB1, NOS2 and CCL21 genes in the range of 1.5 to 3.7-folds. The flow cytometry based cell cycle analysis suggested the transfer of 15.2 2.1% (p < 0.01) population of ZnFe{sub 2}O{sub 4}-NPs (100 ?g/ml) treated cells into apoptotic phase through intrinsic pathway. Over all, the data revealed the potential of ZnFe{sub 2}O{sub 4}-NPs to induce cellular and genetic toxicity in cells of placental origin. Thus, the significant ROS production, reduction in ??m, DNA damage, and activation of genes linked to inflammation, oxidative stress, proliferation, DNA damage and repair could serve as the predictive toxicity and stress markers for ecotoxicological assessment of ZnFe{sub 2}O{sub 4}-NPs induced cellular and genetic damage. - Highlights: First report on the molecular toxicity of ZnFe{sub 2}O{sub 4}-NPs in cells of placental origin WISH cells treated with ZnFe{sub 2}O{sub 4}-NPs exhibited cytoplasmic localization of NPs

  13. Benzo[a]pyrene affects Jurkat T cells in the activated state via the antioxidant response element dependent Nrf2 pathway leading to decreased IL-2 secretion and redirecting glutamine metabolism

    SciTech Connect

    Murugaiyan, Jayaseelan; Rockstroh, Maxie; Wagner, Juliane; Baumann, Sven; Schorsch, Katrin; Trump, Saskia; Lehmann, Irina; Bergen, Martin von; Tomm, Janina M.

    2013-06-15

    There is a clear evidence that environmental pollutants, such as benzo[a]pyrene (B[a]P), can have detrimental effects on the immune system, whereas the underlying mechanisms still remain elusive. Jurkat T cells share many properties with native T lymphocytes and therefore are an appropriate model to analyze the effects of environmental pollutants on T cells and their activation. Since environmental compounds frequently occur at low, not acute toxic concentrations, we analyzed the effects of two subtoxic concentrations, 50 nM and 5 μM, on non- and activated cells. B[a]P interferes directly with the stimulation process as proven by an altered IL-2 secretion. Furthermore, B[a]P exposure results in significant proteomic changes as shown by DIGE analysis. Pathway analysis revealed an involvement of the AhR independent Nrf2 pathway in the altered processes observed in unstimulated and stimulated cells. A participation of the Nrf2 pathway in the change of IL-2 secretion was confirmed by exposing cells to the Nrf2 activator tBHQ. tBHQ and 5 μM B[a]P caused similar alterations of IL-2 secretion and glutamine/glutamate metabolism. Moreover, the proteome changes in unstimulated cells point towards a modified regulation of the cytoskeleton and cellular stress response, which was proven by western blotting. Additionally, there is a strong evidence for alterations in metabolic pathways caused by B[a]P exposure in stimulated cells. Especially the glutamine/glutamate metabolism was indicated by proteome pathway analysis and validated by metabolite measurements. The detrimental effects were slightly enhanced in stimulated cells, suggesting that stimulated cells are more vulnerable to the environmental pollutant model compound B[a]P. - Highlights: • B[a]P affects the proteome of Jurkat T cells also at low concentrations. • Exposure to B[a]P (50 nM, 5 μM) did not change Jurkat T cell viability. • Both B[a]P concentrations altered the IL-2 secretion of stimulated cells.

  14. DOE Zero Energy Ready Home Case Study: Evolutionary Home Builders, The

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Adaptation Home, Geneva, IL | Department of Energy Evolutionary Home Builders, The Adaptation Home, Geneva, IL DOE Zero Energy Ready Home Case Study: Evolutionary Home Builders, The Adaptation Home, Geneva, IL DOE Zero Energy Ready Home Case Study: Evolutionary Home Builders, The Adaptation Home, Geneva, IL Case study of a DOE 2015 Housing Innovation Award winning custom home in the cold climate that got a HERS 30 without PV, with 2x8 24" on center walls with blown fiberglass and

  15. IL.06-123 057 I I

    Office of Legacy Management (LM)

    ... Perch10ric and picric acid salts are explosive; they can be detonated by shock, impact, heat, or friction. Before work was performed on the ducts, field tests were performed to ...

  16. Fermilab Cultural Events in Batavia, IL

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Eugene Cheng, Scientist in Residence, School of the Art Institute, Chicago and Professor, University of Sheffield, UK - July 15, 2016 @ 8 pm - 7 Lecture by Vanessa Hill of Brain ...

  17. Il Woong Jung | Argonne National Laboratory

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    for micro- and nano-mechanical devices. Current research focuses on the manipulation of light-matter interaction at the nanoscale, specifically using micro- and nano-mechanical ...

  18. actos_il_v05.ai

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    two figures show measurements performed during the IMPACT campaign 2008 in Cabauw (NL). The data were sampled in a field of shallow cumulus clouds with cloud top in about 2000 m. During this flight leg, ACTOS was at a nearly constant height in 1930 m above ground level and 50 m below cloud top. The left plot shows the time series of reflectance at a wavelength of 1645 nm (red curve) measured onboard the helicopter and effective radius (blue triangles) measured with the PVM onboard ACTOS. The

  19. Fermilab | Science | Questions for the Universe | The Birth of...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Tevatron, Fermilab, Batavia, IL Large Hadron Collider, CERN, Geneva, Switzerland BaBar, SLAC, Menlo Park, CA Further reading courtesy of Symmetry magazine Explain it in 60 Seconds: ...

  20. WIMPs at the galactic center (Journal Article) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Fermi National Accelerator Laboratory, Batavia, IL (United States) CERN, Geneva (Switzerland) Publication Date: 2015-05-01 OSTI Identifier: 1200688 Report Number(s):...

  1. Snapshots of the IL-4 Receptor Ternary Complexes: An Opportunity...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    protein causing movements within the transmembrane region, which conveys the signal more directly across the membrane, where this latter mechanism is beyond the scope...

  2. MIN IMI IlI New Data Series

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Change, Petroleum Products Supplied, and Ending Stocks ... 40 3.1b Imports, Exports, and Net Imports ... 41 3.2 Crude Oil Supply and...

  3. R. Tayloe, NuFact'09 Chicago, IL

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    - W n p CCQE 3 CCQE models The canonical model for the CCQE process is straightforward, and well-constrained. It looks something like this: - Llewellyn-Smith formalism...

  4. OIL WELL REMEDIATION IN CLAY AND WAYNE COUNTIES, IL

    SciTech Connect

    Peter L. Dakuras; Larry Stieber; Dick Young

    2003-02-01

    This is the first technical progress report of the remediation of two wells and a water injection well in Clay County, Illinois. The location is identified as the Routt lease and the wells will be identified as the Routt No.3 and Routt No.4 respectively throughout this report. The Clay County portion of this project has met all legal, financial, and environmental requirements to drill and /or pump oil at this lease. We have also obtained all available information about this site and have taken the necessary steps to improve access roads, dig the necessary pits and build the necessary firewalls. Both wells have been drilled to the Salem formation. Gas gun technology was used to stimulate the reservoir of the Routt No.3. This report will address the technical aspects of the remediation.

  5. #iWNCD W ONTAININO Il@MQWm;

    Office of Legacy Management (LM)

    PERCENTS 17.77 g ', 10 Attention: Nr. RI ' ia God, Jr. AIJO' Div. Pm&. (Agent We have been mqueeted by We est;mate that %t wuld be ptmalble to edd &mNa&drlf 1500 man-hours rt ...

  6. MEMORANDUM TO: FILE F3on: A 6 IL

    Office of Legacy Management (LM)

    .Z,+,ECI-INVOLVE?EXT AT SITE . ---... ---... ---- . 1, Control c Health Physics Protection . 0 AECMED managed operations G Little or None 3 AECtlED responsible for ...

  7. Increasing Sugar Yields with IL-final-sm

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Sandia Researchers are investigating blending options to maximize sugar yields. Municipal Solid Waste (MSW) has the potential to be a cost effective blending agent with other ...

  8. QER Public Meeting in Chicago, IL: Rail, Barge, Truck Transportation...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ... (244.14 KB) John Gray, Senior Vice President for Policy and Economics, the Association of American Railroads (AAR) - Statement (592.32 KB) John Gray, Senior Vice President ...

  9. Quadrennial Energy Review Stakeholder Meeting #9: Chicago, IL

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ... energy resources as fuel for vehicles could be important. ... it has not received the traction it needs. 10 Q: What ... and transmission rural electric cooperative that serves ...

  10. Increasing Sugar Yields with IL-final-sm

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Ionic Liquid Processing Increasing sugar yields from diverse biomass feedstock with ionic liquid processing and cultivation of renewable ionic liquids Liberating Sugars from Biomass Lignocellulose, one of the most abundant plants on Earth, has the potential to displace a substantial portion of the fossil fuels currently consumed within the transportation sector. Converting lignocellulose to biofuels requires the disruption of the lignin-carbohydrate complex within the plant and conversion into

  11. Quadrennial Energy Review August 8, 2014 Chicago , Il.

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Ernie Perry, PhD. ebperry@wisc.edu University Of Wisconsin - Madison 2 Freight corridors are multi-state, multi- modal economic networks. Contents o MAFC states are freight states ...

  12. Demonstration of membrane aeration panels: City of Geneva Wastewater Treatment Plant. Final report

    SciTech Connect

    1995-01-01

    This report describes the design, construction, and testing of membrane aeration panels at the Marsh Creek wastewater treatment plant (WWTP) in Geneva, NY. The operators at the Geneva plant have undertaken a long-term program to upgrade wastewater treatment processes and lower operating costs. The aging mechanical surface aerators at the Marsh Creek treatment plant were replaced by a state-of-the-art membrane panel system. This fine-bubble diffused air system offers higher oxygen transfer efficiency than surface aerators or other types of fine-bubble diffused-air systems. The project had four objectives: to decrease the amount of electricity used at the plant for aeration; to enable the plant`s existing aeration basins to accommodate higher organic loads and/or nitrify the wastewater should the need arise; to provide an even distribution of dissolved oxygen within the aeration basins to enhance biological wastewater treatment activity; and to provide technical data to assess the performance of the membrane panel system versus other forms of wastewater aeration.

  13. A Request for Planning Funds for a Research and Study Abroad Facility in Geneva, Switzerland in Affiliation with the European Laboratory for Particle Physics

    SciTech Connect

    campbell, myron

    2013-03-31

    To create a research and study abroad program that would allow U.S. undergraduate students access to the world-leading research facilities at the European Organization for Nuclear Research (CERN), the World Health Organization, various operations of the United Nations and other international organizations based in Geneva.The proposal is based on the unique opportunities currently existing in Geneva. The Large Hadron Collider (LHC) is now operational at CERN, data are being collected, and research results are already beginning to emerge. At the same time, a related reduction of activity at U.S. facilities devoted to particle physics is expected. In addition, the U.S. higher-education community has an ever-increasing focus on international organizations dealing with world health pandemics, arms control and human rights, a nexus also centered in Geneva.

  14. 4-27-11-signed-Final-EA-FONSI-for-BeaconPower--IL-PA-.pdf

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

  15. Proc. of the sixteenth symposium on energy engineering sciences, May 13-15, 1998, Argonne, IL.

    SciTech Connect

    1998-05-13

    This Proceedings Volume includes the technical papers that were presented during the Sixteenth Symposium on Energy Engineering Sciences on May 13--15, 1998, at Argonne National Laboratory, Argonne, Illinois. The Symposium was structured into eight technical sessions, which included 30 individual presentations followed by discussion and interaction with the audience. A list of participants is appended to this volume. The DOE Office of Basic Energy Sciences (BES), of which Engineering Research is a component program, is responsible for the long-term, mission-oriented research in the Department. The Office has prime responsibility for establishing the basic scientific foundation upon which the Nation's future energy options will be identified, developed, and built. BES is committed to the generation of new knowledge necessary to solve present and future problems regarding energy exploration, production, conversion, and utilization, while maintaining respect for the environment. Consistent with the DOE/BES mission, the Engineering Research Program is charged with the identification, initiation, and management of fundamental research on broad, generic topics addressing energy-related engineering problems. Its stated goals are to improve and extend the body of knowledge underlying current engineering practice so as to create new options for enhancing energy savings and production, prolonging the useful life of energy-related structures and equipment, and developing advanced manufacturing technologies and materials processing. The program emphasis is on reducing costs through improved industrial production and performance and expanding the nation's store of fundamental knowledge for solving anticipated and unforeseen engineering problems in energy technologies. To achieve these goals, the Engineering Research Program supports approximately 130 research projects covering a broad spectrum of topics that cut across traditional engineering disciplines. The program focuses on three areas: (1) mechanical sciences, (2) control systems and instrumentation, and (3) engineering data and analysis. The Sixteenth Symposium involved approximately one-fourth of the research projects currently sponsored by the DOE/BES Engineering Research Program.

  16. Preliminary evaluation of a fluorescence and radioisotope nuclear smuggling deterrence tag - final report (IL500E)

    SciTech Connect

    Hartenstein, S.D.; Aryaeinejad, R.; Delmastro, J.R.

    1997-04-01

    This report summarizes the efforts completed in identifying candidate fluorescence compounds and radioisotopes for a developing tagging system. The tagging system is being developed as a deterrent to nuclear smuggling, by providing a means of: (1) tracing materials and pilferers to the facility of origin for any recovered special nuclear materials, (2) inventory control of long-term stored items containing special nuclear materials, and (3) tracking materials transferred between facilities. The system uses three types of materials to cover a range of applications intended to prevent the pilfering of special nuclear materials. One material, fluorescent compounds which are invisible without ultraviolet or near-infrared detection systems, is marked on controlled items with a tracking pattern that corresponds to a specified item in a specified location in the data control system. The tagging system uses an invisible, fluorescent dusting powder to mark equipment and personnel who inappropriately handle the tagged material. The tagging system also uses unique combinations of radionuclides to identify the facility of origin for any special nuclear material. This report also summarizes the efforts completed in identifying hardware that will be used for the tagging system. This hardware includes the devices for applying the tagging materials, the commercially available fluorescence detection systems, and gamma ray detection systems assembled from existing, commercially available technologies.

  17. Airborne gamma-ray spectrometer and magnetometer survey, Belleville quadrangle (IL). Final report

    SciTech Connect

    Not Available

    1981-01-01

    Forty-two uranium anomalies meet the minimum statistical requirements as defined in Volume I. These anomalies are listed and are shown on the Uranium Anomaly Interpretation Map. Potassium (%K), equivalent Uranium (ppM eU), equivalent Thorium (ppM eTh), eU/eTh, eU/K, eTh/K, and magnetic pseudo-contour maps are presented in Appendix E. Stacked Profiles showing geologic strip maps along each flight-line, together with sensor data, and ancillary data are presented in Appendix F. All maps and profiles were prepared on a scale of 1:250,000, but have been reduced to 1:500,000 for presentation in Volume II. Anomalies No. 1, No. 4 to No. 17, No. 22 to No. 23, and No. 27 to No. 30 are over areas underlain by the Radnor Till member (Qti) of the Pleistocene Glasford formation. Anomalies No. 2 and No. 3 are over areas underlain by Pleistocene Cahokia Alluvium (Qc) and the Radnor Till member (Qti) of the Glasford formation. Anomalies No. 18 to No. 21, and No. 24 are over areas underlain by the Pleistocene Equality formation (Qcl). Anomalies No. 25 and No. 26 are over areas underlain by the Equality formation (Qcl) and the Radnor Till member (Qti) of the Glasford formation. Both of these formations are of Pleistocene age. Anomalies No. 31 and No. 33 are over areas underlain by the Pleistocene Cahokia Alluvium (Qc). Anomalies No. 32, No. 34 to No. 38, and No. 40 to No. 42 are over areas underlain by the Radnor Till member (Qti) of the Pleistocene Glasford formation. Anomaly No. 39 is over an area underlain by the Radnor Till (Qti) and the Hagarstown (Qgh) members of the Pleistocene Glasford formation.

  18. Airborne gamma-ray spectrometer and magnetometer survey: Peoria, Decater, Belleville Quadrangles, (IL). Final report

    SciTech Connect

    Not Available

    1981-01-01

    An airborne combined radiometric and magnetic survey was performed for the Department of Energy (DOE) over the area covered by the Peoria, Decatur, and Belleville, 1:250,000 National Topographic Map Series (NTMS), quadrangle maps. The survey was part of DOE's National Uranium Resource Evaluation (NURE) program. Data were collected by a helicopter equipped with a gamma-ray spectrometer with a large crystal volume, and with a high sensitivity proton procession magnetometer. The radiometric system was calibrated at the Walker Field Calibration pads and the Lake Mead Dynamic Test Range. Data quality was ensured during the survey by daily test flights and equipment checks. Radiometric data were corrected for live time, aircraft and equipment background, cosmic background, atmospheric radon, Compton scatter, and altitude dependence. The corrected data were statistically evaluated, plotted, and contoured to produce anomaly maps based on the radiometric response of individual geological units. The anomalies were interpreted and an interpretation map produced. Volume I contains a description of the systems used in the survey, a discussion of the calibration of the systems, the data collection procedures, the data processing procedures, the data presentation, the interpretation rationale, and the interpretation methodology. A separate Volume II for each quadrangle contains the data displays and the interpretation results.

  19. XL-A A.&lx A!i' X!Ii?Z IL';;i'

    Office of Legacy Management (LM)

    CEd as shmcn substantially -7% IjT(-ys. a--;-2-,,, : : .s. . -. .-. .-..- in red on Exhibit :A, atta.ched hereto and made a part hereof,-a,tiii-:: THIS PERMIT is ...

  20. C E N T R A L F IL E S

    Office of Legacy Management (LM)

    ... This aspect did imt aypzar to te 0P r,.q":',cr;y..::- ,;;-.;':y-:: '-.2 the StauiYer-T2me3cal :,ersc3r;el due to t&i2 .:Lc3es5;21 . ..' .,Uory of past opem2l9:x. The cn tee f;est ...

  1. DOE ZERH Case Study: BrightLeaf Homes, McCormick Avenue, Brookfield, IL

    SciTech Connect

    none,

    2015-09-01

    Case study of a DOE 2015 Housing Innovation Award winning production home in the cold climate that got a HERS 38 without PV, with staggered 2x4 studs every 8”on a 2x6 plate with dense-packed R-25 cellulose, basement with 3” XPS exterior and 2: XPS under slab; a vented attic with spray foam top plates and R-60 blown cellulose; 96% AFUE furnace, 14 SEER AC, plus fresh air intake.

  2. DFPARThIl!NT OF ENERGY EERE PROJECT MANAGEMENT CENTER NEPA DETERlIfiNA...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ... impacts to persons (such as from shadow flicker and other visual effects, and noise). ... boundaries of an existing facility. * Wind Turbine - 20 KW or smaller. * Solar Thermal * ...

  3. EA-1975: LINAC Coherent Light Source-Il, SLAC National Accelerator Laboratory, Menlo Park, California

    Energy.gov [DOE]

    DOE prepared an EA on the potential environmental impacts of a proposal to upgrade the existing LINAC Coherent Light Source (LCLS) at the SLAC National Accelerator Laboratory. The proposed LCLS-II would extend the photon energy range, increase control over photon pulses, and enable two-color pump-probe experiments. The X-ray laser beams generated by LCLS-II would enable a new class of experiments: the simultaneous investigation of a material’s electronic and structural properties.

  4. Impacts of antropogenic contaminants on vegetation and groundwater chemistry in a fen complex (IL)

    SciTech Connect

    Nuzzo, V.A.; Hensel, B.; Panno, S.; Cartwright, K.; Krapac, I. Illinois State Geological Survey, Champaign )

    1993-06-01

    Residential development within the watershed of a fen complex has resulted in encroachment of ground-water borne anthropogenic contaminants into 3 high quality fens. Groundwater samples were collected from peat and marl and analyzed for inorganic constituents. Height and density of Typha angustifolia L. and Scirpus acutus Muhl. were recorded in belt transects coincident with ground-water samples. Contaminant plumes from septic systems of houses near the fens had higher Na, Cl, NO[sub 3], and TDS levels than uncontaminated areas of the fens. Typha density increased significantly as Na, Cl, CL/SO[sub 4], and TDS levels increased; Scirpus occurred only where pH [ge] 7.1 (X[sub 2]=11.656, sl=.02). Scirpus density was generally independent of other water chemistry levels. In one fen Scirpus density declined significantly as Typha density increased (r[sub 2]=25.86). Contamination appears to favor Tvpha invasion, which subsequently leads to displacement of Scirpus.

  5. Cover Title Here

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ... Station Canton, IL Edwards Power Station Bartonville, IL Joppa Power Station Joppa, IL Newton Power Station Jasper County, IL MISO (CoalCo) Baldwin Energy Complex Baldwin, IL ...

  6. DOE Zero Energy Ready Home Case Study: BrightLeaf Homes, McCormick Avenue, Brookfield, IL

    Energy.gov [DOE]

    Case study of a DOE 2015 Housing Innovation Award winning production home in the cold climate that got a HERS 38 without PV, with staggered 2x4 studs every 8”on a 2x6 plate with dense-packed R-25 cellulose, basement with 3” XPS exterior and 2: XPS under slab; a vented attic with spray foam top plates and R-60 blown cellulose; 96% AFUE furnace, 14 SEER AC, plus fresh air intake.

  7. New Whole-House Solutions Case Study: Meeting DOE Challenge Home Program Certification - Chicago, IL; Denver, CO; Devens, MA

    SciTech Connect

    2015-01-01

    In this project, three production home builders—K. Hovnanian Homes, David Weekley Homes, and Transformations, Inc.—partnered with Building America team Building Science Corporation to evaluate the certification of five test homes to the new DOE Challenge Home program performance standard (now DOE Zero Energy Ready Home program). The builders identified key benefits and barriers that impacted the certification of the test homes, and the likelihood of whether DOE Challenge Home certification would be pursued in future homes

  8. Natural Gas and Hydrogen Infrastructure Opportunities Workshop, October 18-19, 2011, Argonne National Laboratory, Argonne, IL : Summary Report.

    SciTech Connect

    Kumar, R. comp.; Ahmed, S. comp.

    2012-02-21

    The overall objective of the Workshop was to identify opportunities for accelerating the use of both natural gas (NG) and hydrogen (H{sub 2}) as motor fuels and in stationary power applications. Specific objectives of the Workshop were to: (1) Convene industry and other stakeholders to share current status/state-of-the-art of NG and H{sub 2} infrastructure; (2) Identify key challenges (including non-technical challenges, such as permitting, installation, codes, and standards) preventing or delaying the widespread deployment of NG and H{sub 2} infrastructure. Identify synergies between NG and H{sub 2} fuels; and (3) Identify and prioritize opportunities for addressing the challenges identified above, and determine roles and opportunities for both the government and industry stakeholders. Plenary speakers and panel discussions summarized the current status of the NG and H{sub 2} infrastructure, technology for their use in transportation and stationary applications, and some of the major challenges and opportunities to more widespread use of these fuels. Two break-out sessions of three groups each addressed focus questions on: (1) infrastructure development needs; (2) deployment synergies; (3) natural gas and fuel cell vehicles (NGVs, FCVs), specialty vehicles, and heavy-duty trucks; (4) CHP (combined heat and power), CHHP (combined hydrogen, heat, and power), and synergistic approaches; and (5) alternative uses of natural gas.

  9. Technical description of candidate fluorescence compounds and radioisotopes for a nuclear smuggling deterrence tag (IL500E)

    SciTech Connect

    Hartenstein, S.D.; Aryaeinejad, R.

    1996-03-01

    This report summarizes the efforts completed in identifying candidate fluorescence compounds and radioisotopes for a developing tagging system. The tagging system is being developed as a deterrent to nuclear smuggling, by providing a means of: (1) tracing materials and pilferers to the facility of origin for any recovered special nuclear materials; (2) inventory control of long-term stored items containing special nuclear materials; and (3) tracking materials transferred between facilities. The tagging system uses four types of tagging materials to cover a range of applications intended to prevent the pilfering of special nuclear materials. One material, fluorescent compounds which are invisible without ultraviolet or near-infrared detection systems, is marked on controlled items with a tracking pattern that corresponds to a specified item in a specified location in the data control system. The tagging system uses an invisible, fluorescent dusting powder to mark equipment and personnel who inappropriately handle the tagged material. The tagging system also uses unique combinations of radionuclides to identify the facility of origin for any special nuclear material. Currently, 18 long-lived radioisotopes, 38 short-live radioisotopes and 10 fluorescent compounds have been selected as candidate materials for the tagging system.

  10. Origin State>> CA CA ID ID IL KY NJ NM NY NY NV OH OH OH SC

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Mound Closure Project Portsmouth Gaseous Diffusion Plant Fernald Closure Project Savannah River Site BWXT Y-12 Plant Duratek Nuclear Fuels UT-Battelle Bechtel Jacobs Permafix M&EC ...

  11. Origin State>> CA CA ID ID IL KY NJ NM NY NY NV OH OH OH SC

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Mix Wastew Treatment Project Argonne National Laboratory Paducah Gaseous Diffusion Plant Princeton Plasma Physics Laboratory Sandia National Laboratory Brookhaven National ...

  12. Acoustic Building Infiltration Measurement System (ABIMS)

    Office of Energy Efficiency and Renewable Energy (EERE)

    Lead Performer: Argonne National Laboratory - Lemont, IL Partner: Illinois Institute of Technology - Chicago, IL

  13. J. Taylor Childers III | Argonne National Laboratory

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    J. Taylor Childers III Assistant Physicist Education 2002 - 2007 University of Minnesota, PhD. in Physics 1998 - 2002 University of Kentucky, BS. in Physics Experience 2013 - present Assistant Physicist at Argonne National Lab, Chicago, IL, USA 2011 - 2013 Fellow at CERN, Geneva, Switzerland 2007 - 2011 Postdoctoral Researcher at Heidelberg University, Heidelberg, Germany Summary of Research I am an Assistant Physicist at Argonne National Laboratory in Chicago, USA. As a member of ATLAS, I am

  14. ,"Illinois Natural Gas Summary"

    Energy Information Administration (EIA) (indexed site)

    Prices" "Sourcekey","N3050IL3","N3010IL3","N3020IL3","N3035IL3","N3045IL3" "Date","Natural Gas Citygate Price in Illinois (Dollars per Thousand Cubic Feet)","Illinois Price of ...

  15. Workplace Charging Challenge Partner: Township High School District 214

    Energy.gov [DOE]

    Joined the Challenge: October 2014Headquarters: Arlington Heights, ILCharging Locations: Arlington Heights, IL; Buffalo Grove, IL; Elk Grove Village, IL; Mount Prospect, IL; Rolling Meadows, IL;...

  16. Formerly utilized MED/AEC sites remedial action program post-remedial-action radiological survey of Kent Chemical Laboratory, the University of Chicago, Chicago, IL

    SciTech Connect

    Wynveen, R.A.; Smith, W.H.; Sholeen, C.M.; Justus, A.L.; Flynn, K.F.

    1983-05-01

    A comprehensive radiological assessment of Kent Laboratory was conducted during September 1977, by the ANL Radiological Survey Group to determine if any radioactive contamination remained. The results of the assessment indicated the need for remedial action. Since 1977, the University has decontaminated this laboratory building, and in May 1983, the Department of Energy requested the ANL Radiological Survey Group to conduct a post-remedial-action survey. All the contaminated areas identified during the 1977 assessment were rechecked. Contamination remained in six of the rooms. Further decontamination of these areas was conducted by university personnel, and as a result, these areas are now free of contamination. However, a contaminated clay pipe in the attic remained. The clay pipe has since been removed and disposed of as solid radioactive waste. During the post-remedial-action survey, six soil samples were collected from excavation trenches dug in Rooms 1 and 2 as part of the University's remedial action efforts. Also, four sludge samples were taken from below the manhole covers in the basement of Kent Chemical Laboratory to assess the radiological condition of the sewer system. A radiological assessment of the sewer system had not been accomplished during the 1977 survey as per program direction. Radiochemical (fluorometric) and gamma-spectral analyses indicated that eight out of ten soil and sludge samples contained levels of radioactivity above expected background concentrations. The soil has since been further excavated. The building is now free of radioactive contamination in excess of background levels; however, the sewers do contain radioactive materials above background levels since contamination was found at appropriate access points. 6 references, 16 figures, 7 tables.

  17. Instabilities and chaos in quantum optics II; Proceedings of the NATO Advanced Study Institute, Il Ciocco, Italy, June 28-July 7, 1987

    SciTech Connect

    Abraham, N.B.; Arecchi, F.T.; Lugiato, L.A.

    1988-01-01

    The following topics are considered: laser and maser instabilities, classical and quantum noise, transverse effects, dynamics in optical bistability and nonlinear optical media, and methods of analysis in nonlinear dynamics. Particular papers are presented on multistability and chaos in a two-photon microscopic maser, quantum chaos in quantum optics, spatial chaos in bistable optical arrays, four-wave mixing and dynamics, and bifurcation problems in nonlinear optics.

  18. Heat transfer in ocean thermal energy conversion (OTEC) systems. Proceedings of the wanter mnnual Meeting, Chicago, IL, November 16-21, 1980

    SciTech Connect

    Owens, W.L.

    1980-01-01

    Among the topics discussed are: condensation heat transfer on long vertical, axially ridged tubes tests of the Applied Physics Laboratory of Johns Hopkins University (APL/JHU) folded-tube, Ocean Thermal Energy Conversion (OTEC) heat exchanger the design of a 1.0-MW OTEC heat exchanger for ocean testing and convective vaporization and condensation in serrated-fin channels. Also considered are: heat tranfer studies of an improved heat transfer monitor for OTEC an analysis of the mist lift process for mist flow, open-cycle OTEC the heat transfer characteristics of working fluids for OTEC and a comparison of major OTEC power system characteristics.

  19. Luminescent host–guest materials of electrostatically adsorbed Eu{sup 3+}(tta){sub 3}-tpyIL on zeolite L crystals

    SciTech Connect

    Li, Peng; Wang, Dongyue; Liang, Dong; Zhang, Li; Zhang, Shuming; Wang, Yige

    2014-07-01

    Graphical abstract: Luminescent host–guest materials exhibiting tunable emission colors by changing the excitation wavelength are obtained by surface modification of terbium(III) bipyridine-loaded zeolite L crystals with the ionic europium(III) complexes. - Highlights: • Luminescent ionic europium(III) complex was synthesized. • Outer surface of zeolite L was modified by electrostatic adsorption of the ionic complex. • Luminescent host–guest material with tunable emission color was obtained. - Abstract: The surface modification of zeolite L crystals with lanthanide complexes was achieved by electrostatic adsorption of ionic europium(III) complexes that are prepared by the reaction of tris(2-thenoyltrifluoroacetonate) europium(III) dehydrate with an organic salt containing terpyridine moieties on the negative charge-bearing surfaces of zeolite L crystals. Luminescent host–guest materials exhibiting tunable emission colors by changing the excitation wavelength are obtained by surface modification of terbium(III) bipyridine-loaded zeolite L crystals with the ionic europium(III) complexes.

  20. Biogas and alcohol fuels production. Proceedings of the Seminar on Biomass, Energy for City, Farm, and Industry, Chicago, IL, October 25, 26, 1979

    SciTech Connect

    Goldstein, J.

    1980-01-01

    Basic principles of anaerobic digestion are considered along with the status of the Imperial Valley Biogas Project, the Department of Energy program for the recovery of energy and materials from urban waste, the principles of alcohol production from wastes, the mechanical recovery of a refuse-derived cellulosic feedstock for ethanol production, and the production of ethanol from cellulosic biomass. Attention is given to on-farm alcohol fuel production, the current status and future role of gasohol production, methane generation from small scale farms, farmsite installations of energy harvester anaerobic digesters, biogas/composting and landfill recovery, farm-scale composting as an option to anaerobic digestion, designing a high-quality biogas system, and methane as fuel of the future. A description is presented of subjects which are related to landfill gas recovery, biogas purification with permselective membranes, and anaerobic digestion of marine biomass. Other topics studied include the application of biogas technology in India, biogas production in China, biogasification of organic wastes in the Republic of the Philippines, and economics and operational experience of full-scale anaerobic dairy manure digester.

  1. Spin Hall effects in metallic antiferromagnets - perspectives...

    Office of Scientific and Technical Information (OSTI)

    60439, USA, Department of Physics and Astronomy, Northwestern University, Evanston IL ... IL 60616, USA Department of Physics and Astronomy, Northwestern University, Evanston IL ...

  2. Energy Savings with Acceptable Indoor Air Quality Through Improved Air Flow Control in Residential Retrofit

    Office of Energy Efficiency and Renewable Energy (EERE)

    Lead Performer: Gas Technology Institute—Des Plaines, IL Partners: -- University of Illinois, Urbana IL -- Midwest Energy Efficiency Alliance, Chicago IL

  3. Athletic equipment microbiota are shaped by interactions with...

    Office of Scientific and Technical Information (OSTI)

    Chicago, IL (United States) Argonne National Lab. (ANL), Lemont, IL (United States) MO BIO Lab., Inc., Carlsbad, CA (United States) Argonne National Lab. (ANL), Lemont, IL (United ...

  4. Geneva, Switzerland: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    lse,"poi":true,"imageoverlays":,"markercluster":false,"searchmarkers":"","locations":"text":"","title":"","link":null,"lat":46.2038099,"lon":6.1399589,"alt":0,"address":"","ico...

  5. Analysis of natural gases, AL, AR, FL, GA, IL, IN, IA, KY, LA, MD, MI, MS, MO, NJ, NY, NC, OH, PA, TN, VA, and WV; 1951-1991 (for microcomputers). Data file

    SciTech Connect

    Not Available

    1991-01-01

    The U.S. Bureau of Mines diskette contains analysis and related source data for 2,357 natural gas samples collected from miscellaneous states, which include the following states: Alabama, Arkansas (except Arkoma Basin), Florida, Georgia, Illinois, Indiana, Iowa, Kentucky, Louisiana, Maryland, Michigan, Mississippi, Missouri, New Jersey, New York, North Carolina, Ohio, Pennsylvania, Tennessee, Virginia, and West Virginia. All samples were obtained and analyzed as part of the Bureau's investigations of occurrences of helium in natural gases of countries with free market economies. The survey has been conducted since 1917. The analysis contained on the diskette contain the full range of component analysis data. Five files are on the diskette: READ.ME, MISC.TXT, MISC.DBF, USHEANAL.DBF, and BASINCDE.TXT.

  6. DOE - Office of Legacy Management -- Swenson Evaporator Co -...

    Office of Legacy Management (LM)

    IL.23-1 Evaluation Year: 1987 IL.23-1 Site Operations: Scheduled a raffinate spray drying test that was later cancelled. IL.23-1 Site Disposition: Eliminated - No indication...

  7. Southwestern Power Administration

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    032614 Correspondence between SWPA and 13 members of Congress: Paul Broun, R-GA, Rodney Davis R-IL, John Delaney, D-MD, Jeff Denham R-CA. Robert Dold R-IL, Bill Enyart D-IL, Bill...

  8. DOE - Office of Legacy Management -- GSA 39th Street Warehouse...

    Office of Legacy Management (LM)

    GSA 39th Street Warehouse - IL 02 FUSRAP Considered Sites Site: GSA 39TH STREET WAREHOUSE (IL.02 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated ...

  9. NETL F 451.1/1-1, Categorical Exclusion Designation Form

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    - Grantsburg, IL and Noble, IL FESCCStorage Division Bruce Brown A Nonconventional CO2-EOR Target in the Illinois Basin: Oil Reservoirs of the.. Project planning, data...

  10. DOE - Office of Legacy Management -- Max Zuckerman and Sons ...

    Office of Legacy Management (LM)

    - IL 30 FUSRAP Considered Sites Site: MAX ZUCKERMAN & SONS (IL.30 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: 1925...

  11. EIS-0394: EPA Notice of Availability of the Draft Environmental...

    Energy.gov [DOE] (indexed site)

    Planning, Design, Construction and Operation a Coal Fueled Electric Power and Hydrogen Gas Production Plant, Four Alternative Sites: Mattoon, IL, Tuscola, IL, Jewett, TX and...

  12. DOE Zero Energy Ready Home Case Study: Weiss Building & Development...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Weiss Building & Development LLC, System Home, River Forest, IL DOE Zero Energy Ready Home Case Study: Weiss Building & Development LLC, System Home, River Forest, IL Case study of ...

  13. Predicting ecological roles in the rhizosphere using metabolome...

    Office of Scientific and Technical Information (OSTI)

    States). Biosciences Div.; Univ. of Chicago, Chicago, IL (United States). Dept. of Bioengineering. Argonne National Lab., Argonne, IL (United States). Biosciences Div. Univ. of...

  14. DOE - Office of Legacy Management -- Kankakee Ordnance Plant...

    Office of Legacy Management (LM)

    Kankakee Ordnance Plant - IL 32 FUSRAP Considered Sites Site: KANKAKEE ORDNANCE PLANT (IL.32 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated ...

  15. DOE - Office of Legacy Management -- American Machine and Metals...

    Office of Legacy Management (LM)

    Metals Inc - IL 24 FUSRAP Considered Sites Site: American Machine and Metals Inc (IL.24 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name:...

  16. Using RSI format

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... University, Evanston, IL 60208. c Present address: Hebrew University, Jerusalem, Israel. d Present address: Northwestern University, Evanston, IL 60208. e Present ...

  17. DOE - Office of Legacy Management -- R Krasberg and Sons Manufacturing...

    Office of Legacy Management (LM)

    Krasberg and Sons Manufacturing Co - IL 27 FUSRAP Considered Sites Site: R. KRASBERG AND SONS MANUFACTURING CO. (IL.27) Eliminated from consideration under FUSRAP Designated Name:...

  18. DOE - Office of Legacy Management -- Midwest Manufacturing Co...

    Office of Legacy Management (LM)

    Midwest Manufacturing Co - IL 0-04 FUSRAP Considered Sites Site: MIDWEST MANUFACTURING CO (IL.0-04 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated...

  19. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Argonne National Laboratory (ANL), Argonne, IL (United States) Argonne National Laboratory-Advanced Photon Source, Argonne, IL (United States) Atlanta Regional Office, ...

  20. Cluster generator (Patent) | DOEPatents

    Office of Scientific and Technical Information (OSTI)

    Inventors: Donchev, Todor I. 1 ; Petrov, Ivan G. 2 + Show Author Affiliations (Urbana, IL) (Champaign, IL) Issue Date: 2011-05-31 OSTI Identifier: 1019407 Assignee: The Board ...

  1. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Laboratory (ANL), Argonne, IL (United States) Argonne National Laboratory-Advanced Photon Source, Argonne, IL (United States) Atlanta Regional Office, Atlanta, GA (United ...

  2. The soil microbiome influences grapevine-associated microbiota...

    Office of Scientific and Technical Information (OSTI)

    (ANL), Argonne, IL (United States); Univ. of Chicago, Chicago, IL (United States); Marine Biological Lab., Woods Hole, MA (United States); Zhejiang Univ., Hangzhou (China)...

  3. The structural basis for receptor recognition of human interleukin-18

    SciTech Connect

    Tsutsumi, Naotaka; Kimura, Takeshi; Arita, Kyohei; Ariyoshi, Mariko; Ohnishi, Hidenori; Yamamoto, Takahiro; Zuo, Xiaobing; Maenaka, Katsumi; Park, Enoch Y.; Kondo, Naomi; Shirakawa, Masahiro; Tochio, Hidehito; Kato, Zenichiro

    2014-12-15

    Interleukin (IL)-18 is a proinflammatory cytokine that belongs to the IL-1 family and plays an important role in inflammation. The uncontrolled release of this cytokine is associated with severe chronic inflammatory disease. IL-18 forms a signalling complex with the IL-18 receptor α (Rα) and β (Rβ) chains at the plasma membrane, which induces multiple inflammatory cytokines. Here, we present a crystal structure of human IL-18 bound to the two receptor extracellular domains. Generally, the receptors’ recognition mode for IL-18 is similar to IL-1β; however, certain notable differences were observed. The architecture of the IL-18 receptor second domain (D2) is unique among the other IL-1R family members, which presumably distinguishes them from the IL-1 receptors that exhibit a more promiscuous ligand recognition mode. The structures and associated biochemical and cellular data should aid in developing novel drugs to neutralize IL-8 activity.

  4. The structural basis for receptor recognition of human interleukin-18

    DOE PAGES [OSTI]

    Tsutsumi, Naotaka; Kimura, Takeshi; Arita, Kyohei; Ariyoshi, Mariko; Ohnishi, Hidenori; Yamamoto, Takahiro; Zuo, Xiaobing; Maenaka, Katsumi; Park, Enoch Y.; Kondo, Naomi; et al

    2014-12-15

    Interleukin (IL)-18 is a proinflammatory cytokine that belongs to the IL-1 family and plays an important role in inflammation. The uncontrolled release of this cytokine is associated with severe chronic inflammatory disease. IL-18 forms a signalling complex with the IL-18 receptor α (Rα) and β (Rβ) chains at the plasma membrane, which induces multiple inflammatory cytokines. Here, we present a crystal structure of human IL-18 bound to the two receptor extracellular domains. Generally, the receptors’ recognition mode for IL-18 is similar to IL-1β; however, certain notable differences were observed. The architecture of the IL-18 receptor second domain (D2) is uniquemore » among the other IL-1R family members, which presumably distinguishes them from the IL-1 receptors that exhibit a more promiscuous ligand recognition mode. The structures and associated biochemical and cellular data should aid in developing novel drugs to neutralize IL-8 activity.« less

  5. --No Title--

    Energy Information Administration (EIA) (indexed site)

    | (Continued) | ct I | | | | | Year |(Conti-| | | | | | | Month | nued) | | | | | | | ||Average| IL | IN | MI | MN | OH |...

  6. EA-1716: Final Environmental Assessment

    Office of Energy Efficiency and Renewable Energy (EERE)

    Honeywell International Inc Electric Drive Vehicle Battery and Component Manufacturing Initiative Project Massac County, IL

  7. Rotary Vapor Compression Cycle Technology: A Pathway to Ultra-Efficient Air Conditioning, Heating and Refrigeration

    Office of Energy Efficiency and Renewable Energy (EERE)

    Lead Performer: Sandia National Laboratories, Livermore, CAPartners: Creative Thermal Solutions, Urbana, IL

  8. Interaction of interleukin-5 with its receptors on murine leukemic BCL1 cells and its implication in biological activity

    SciTech Connect

    Tsuruoka, N.; Funakoshi, K.; Kodama, S.; Tsujimoto, M. (Suntory Institute for Biomedical Research, Mishima, Osaka (Japan))

    1990-02-01

    Interaction of interleukin (IL)-5 with its receptors on murine leukemic cell line, BCL1 cells was examined. {sup 125}I-labeled recombinant murine IL-5(rmIL-5) bound specifically to high-affinity receptors on BCL1 cells. rmIL-5, which was about 2500-fold more active than recombinant human IL-5(rhIL-5) in IgM-inducing activity on BCL1 cells, also showed about 5000-fold higher affinity to receptors. These results suggest that the bioactivity of IL-5 correlates with its receptor-binding activity. When disulfide bond formation was blocked, rmIL-5 dissociated into a monomer and lost its biological activity. This monomeric form of rmIL-5 also lost its ability to bind to cells, suggesting that dimer formation is essential for the biological activity of IL-5.

  9. Interleukin-8 promotes canine hemangiosarcoma growth by regulating the tumor microenvironment

    SciTech Connect

    Kim, Jong-Hyuk; Frantz, Aric M.; Anderson, Katie L.; Graef, Ashley J.; Scott, Milcah C.; Robinson, Sally; Sharkey, Leslie C.; O'Brien, Timothy D.; Dickerson, Erin B.; Modiano, Jaime F.

    2014-04-15

    Interleukin-8 (IL-8) gene expression is highly up-regulated in canine hemangiosarcoma (HSA); however, its role in the pathogenesis of this disease is unknown. We investigated the expression of IL-8 in canine HSA tissues and cell lines, as well and the effects of IL-8 on canine HSA in vitro, and in vivo using a mouse xenograft model for the latter. Constitutive expression of IL-8 mRNA, IL-8 protein, and IL-8 receptor were variable among different tumor samples and cell lines, but they showed stable steady states in each cell line. Upon the addition of IL-8, HSA cells showed transient intracellular calcium fluxes, suggesting that their IL-8 receptors are functional and that IL-8 binding activates relevant signaling pathways. Yet, neither addition of exogenous IL-8 nor blockade of endogenous IL-8 by neutralizing anti-IL-8 antibody (α-IL-8 Ab) affected HSA cell proliferation or survival in vitro. To assess potential effects of IL-8 in other tumor constituents, we stratified HSA cell lines and whole tumor samples into “IL-8 high” and “IL-8 low” groups. Genome-wide gene expression profiling showed that samples in the “IL-8 high” tumor group were enriched for genes associated with a “reactive microenvironment,” including activation of coagulation, inflammation, and fibrosis networks. Based on these findings, we hypothesized that the effects of IL-8 on these tumors were mostly indirect, regulating interactions with the microenvironment. This hypothesis was supported by in vivo xenograft experiments where survival and engraftment of tumor cells was inhibited by administration of neutralizing α-IL-8 Ab. Together, our results suggest that IL-8 contributes to establishing a permissive microenvironment during the early stages of tumorigenesis in HSA. - Highlights: • IL-8 is expressed in canine hemangiosarcoma tumor samples and cell lines. • IL-8 transduces a relevant biological signal in canine hemangiosarcoma cells. • IL-8 gene signature is associated

  10. The microwave assisted synthesis of 1-alkyl-3-methylimidazolium bromide as potential corrosion inhibitor toward carbon steel in 1 M HCl solution saturated with carbon dioxide

    SciTech Connect

    Pasasa, Norman Vincent A. Bundjali, Bunbun; Wahyuningrum, Deana

    2015-09-30

    Injection of corrosion inhibitor into the fluid current of oil and gas pipelines is an effective way to mitigate corrosion rate on the inner-surface parts of pipelines, especially carbon steel pipelines. In this research, two alkylimidazolium ionic liquids, 1-decyl-3-methylimidazolium bromide (IL1) and 1-dodecyl-3-methylimidazolium bromide (IL2) have been synthesized and studied as a potential corrosion inhibitor towards carbon steel in 1 M HCl solution saturated with carbon dioxide. IL1 and IL2 were synthesized using microwave assisted organic synthesis (MAOS) method. Mass Spectrometry analysis of IL1 and IL2 showed molecular mass [M-H+] peak at 223.2166 and 251.2484, respectively. The FTIR,{sup 1}H-NMR and {sup 13}C-NMR spectra confirmed that IL1 and IL2 were successfully synthesized. Corrosion inhibition activity of IL1 and IL2 were determined using weight loss method. The results showed that IL1 and IL2 have the potential as good corrosion inhibitors with corrosion inhibition efficiency of IL1 and IL2 are 96.00% at 100 ppm (343 K) and 95.60% at 50 ppm (343 K), respectively. The increase in the concentration of IL1 and IL2 tends to improve their corrosion inhibition activities. Analysis of the data obtained from the weight loss method shows that the adsorption of IL1 and IL2 on carbon steel is classified into chemisorption which obeys Langmuir’s adsorption isotherm.

  11. DOE - Office of Legacy Management -- Granite City Army Depot...

    Office of Legacy Management (LM)

    Site was used for storage of GSA thorium residues until circa 1964. IL.0-02-1 Site ... Primary Radioactive Materials Handled: Thorium IL.0-02-1 Radiological Survey(s): None ...

  12. Local Hotels | Argonne National Laboratory

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Additional Hotels AmeriSuites Burr Ridge 15 W. 90 N. Frontage Road Burr Ridge, IL 60521 Reservations: 630323-7530 La Quinta 225 W. South Frontage Road Bolingbrook, IL 60440 ...

  13. DOE - Office of Legacy Management -- W E Pratt Manufacturing...

    Office of Legacy Management (LM)

    E Pratt Manufacturing Co - IL 12 FUSRAP Considered Sites Site: W.E. PRATT MANUFACTURING ... under FUSRAP Also see Documents Related to W.E. PRATT MANUFACTURING CO. IL.12-1 - Letter, ...

  14. RPT_PERIOD","R_S_NAME","LINE_NUM","PROD_CODE","PROD_NAME","PORT...

    Energy Information Administration (EIA) (indexed site)

    PROCESSOR-IL","IL","ILLINOIS",2 "applicationvnd.ms-excel","ATLANTIC TRADING MARKETING ",7,025,"Crude Oil",3401,"PEMBINA, ND","NORTH DAKOTA",2,260,"CANADA",58,3.14,14,"UNK...

  15. RPT_PERIOD","R_S_NAME","LINE_NUM","PROD_CODE","PROD_NAME","PORT...

    Energy Information Administration (EIA) (indexed site)

    PROCESSOR-IL","IL","ILLINOIS",2 "applicationvnd.ms-excel","ATLANTIC TRADING MARKETING ",4,025,"Crude Oil",3401,"PEMBINA, ND","NORTH DAKOTA",2,260,"CANADA",1,3.14,14,"UNKN...

  16. DOE - Office of Legacy Management -- International Register ...

    Office of Legacy Management (LM)

    Year: 1987 IL.15-3 Site Operations: Limited testing of centerless grinding techniques for uranium metal for the AEC. IL.15-2 Site Disposition: Eliminated - Potential for...

  17. DOE - Office of Legacy Management -- Armour Research Foundation...

    Office of Legacy Management (LM)

    , Illinois IL.17-1 Evaluation Year: 1985 IL.17-3 Site Operations: Facility operated a research reactor and conducted associated research for the AEC beginning in the late 1940s. ...

  18. Natural Gas Weekly Update

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    In the Midwest, Horizon pipeline received approval to begin construction of a 70-mile pipeline from Joliet, IL north to McHenry, IL. When completed, the project will add...

  19. DOE - Office of Legacy Management -- Great Lakes Carbon Corp...

    Office of Legacy Management (LM)

    Operations: Facility performed a limited amount of nuclear fuel fabrication in the 1950s. ... performed IL.21-1 Radioactive Materials Handled: Yes IL.21-3 Primary Radioactive ...

  20. DOE Zero Energy Ready Home Case Study: BrightLeaf Homes, McCormick...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    BrightLeaf Homes, McCormick Avenue, Brookfield, IL DOE Zero Energy Ready Home Case Study: BrightLeaf Homes, McCormick Avenue, Brookfield, IL DOE Zero Energy Ready Home Case Study: ...

  1. Workbook Contents

    Energy Information Administration (EIA) (indexed site)

    Date:","12312015" ,"Next Release Date:","01292016" ,"Excel File Name:","n3050il3m.xls" ,"Available from Web Page:","http:tonto.eia.govdnavnghistn3050il3m.htm"...

  2. Microsoft Word - ESnetServiceLevels-V4.0.doc

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... Denver, CO 10G ILLINOIS Inter CAMPUS COMMUNICATION NETWORK (ICCN) Chicago, IL 10G INDIANA ... NM 1G CIC-OMNIPOP Chicago, IL 10G PACIFIC WAVE Seattle WA 10G PACIFIC WAVE Sunnyvale CA, ...

  3. Workbook Contents

    Energy Information Administration (EIA) (indexed site)

    File Name:","n3020il4m.xls" ,"Available from Web Page:","http:tonto.eia.govdnavnghistn3020il4m.htm" ,"Source:","Energy Information Administration" ,"For Help,...

  4. DOE - Office of Legacy Management -- Wyckoff Drawn Steel Co ...

    Office of Legacy Management (LM)

    Drawn Steel Co - IL 0-09 FUSRAP Considered Sites Site: Wyckoff Drawn Steel Co (IL 0-09) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: ...

  5. "2014 Retail Power Marketers Sales- Residential"

    Energy Information Administration (EIA) (indexed site)

    ... Solutions Corp.","IL","Power Marketer",477853,4492034,227638.8,5.0676108 "Green Mountain Energy Company","IL","Power Marketer",24959,190336,16176.4,8.4988652 "Homefield ...

  6. "2014 Retail Power Marketers Sales- Total"

    Energy Information Administration (EIA) (indexed site)

    ... "Glacial Energy Holdings","IL","Power Marketer",2426,128194,8721.1,6.8030485 "Green Mountain Energy Company","IL","Power Marketer",24967,198273,16620.1,8.3824323 "Homefield ...

  7. "2014 Retail Power Marketers Sales- Commercial"

    Energy Information Administration (EIA) (indexed site)

    ... "Glacial Energy Holdings","IL","Power Marketer",2426,128194,8721.1,6.8030485 "Green Mountain Energy Company","IL","Power Marketer",8,7937,443.7,5.5902734 "Homefield ...

  8. Fermilab | Photowalk | 2015 Photowalk: Winning Images

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    here. Top Three Photos thumb First place photo by Mike Baker, Bolingbrook, IL Hi-res Med-res thumb Second place photo by Mike Baker, Bolingbrook, IL Hi-res Med-res thumb...

  9. Fermilab | Photowalk | 2012 Winning Images

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    information. Top Five Photos thumb First place photo by Stan Kirschner, Mundelein, IL Hi-res Med-res thumb Second place photo by Brian Schultz, Naperville, IL Hi-res Med-res...

  10. Gas Technology Institute (Partnership for Advanced Residential...

    OpenEI (Open Energy Information) [EERE & EIA]

    Technology Institute (Partnership for Advanced Residential Retrofit) Jump to: navigation, search Name: Gas Technology Institute Place: Des Plaines, IL Website:...

  11. Utilization Technology Institute | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Utilization Technology Institute Jump to: navigation, search Name: Utilization Technology Institute Place: Des Plaines, IL References: Utilization Technology Institute1...

  12. Low-Cost Gas Heat Pump For Building Space Heating

    Energy.gov [DOE]

    Lead Performer: Stone Mountain Technologies - Erwin, TN Partners: -- A.O. Smith - Milwaukee, WI -- Gas Technology Institute - Des Plaines, IL

  13. computational-fluid-dynamics-training

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Table of Contents Date Location Advanced Hydraulic and Aerodynamic Analysis Using CFD March 27-28, 2013 Argonne TRACC Argonne, IL Computational Hydraulics and Aerodynamics using STAR-CCM+ for CFD Analysis March 21-22, 2012 Argonne TRACC Argonne, IL Computational Hydraulics and Aerodynamics using STAR-CCM+ for CFD Analysis March 30-31, 2011 Argonne TRACC Argonne, IL Computational Hydraulics for Transportation Workshop September 23-24, 2009 Argonne TRACC West Chicago, IL

  14. Recent results from the Tevatron (Conference) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Research Org: Fermi National Accelerator Laboratory (FNAL), Batavia, IL Sponsoring Org: ... DETECTION; PARTICLE RAPIDITY; PHOSPHORS; QUANTUM CHROMODYNAMICS; STANDARD MODEL; ...

  15. Construction Safety Advisory Committee, Meeting Minutes- May 23, 2002

    Energy.gov [DOE]

    Description of CSAC agenda activities during CSAC meeting in Chicago, IL. The meeting was held on May 23, 2002.

  16. Regulation of the human interleukin-2/interleukin-2 receptor system: A role for immunosuppression

    SciTech Connect

    Kaempfer, R.

    1994-12-31

    The strength of the cellular immune response is regulated to a large extent by the amount of interleukin-2 (IL-2) produced in response to a stimulus. The ability of lymphocytes and other cells to respond to IL-2 depends upon the expression of cell surface IL-2 receptors. Formation of a high-affinity IL-2 receptor is regulated primarily through induction of its {alpha} subunit, IL-2R{alpha}. Once formed, the IL-2R{alpha} chain turns over rapidly, rendering expression of high-affinity IL-2 receptors during the immune response dependent upon continuous activity of the IL-2R{alpha} gene. The induced expression of both human IL-2 and IL-2R{alpha} chains is sensitive to cell-mediated suppression by CD8 cells; depletion of CD8 cells leads to extensive superinduction. This coupled suppression of IL-2 and IL-2R{alpha} genes greatly increases the extend of control, and strongly limits the strength, of the signal transduced by this ligand/receptor system during an immune response. 29 refs., 3 figs.

  17. The depletion of Interleukin-8 causes cell cycle arrest and increases the efficacy of docetaxel in breast cancer cells

    SciTech Connect

    Shao, Nan; Chen, Liu-Hua; Ye, Run-Yi; Lin, Ying; Wang, Shen-Ming

    2013-02-15

    Highlights: ► IL-8 depletion affects cell cycle distribution. ► Intrinsic IL-8 mediates breast cancer cell migration and invasion. ► IL-8 siRNA down regulates key factors that control survival and metastatic pathway. ► IL-8 depletion reduces integrin β3 expression. ► IL-8 depletion increases the chemosensitivity to docetaxel. -- Abstract: IL-8 is a multi-functional pro-inflammatory chemokine, which is highly expressed in cancers, such as ER-negative breast cancer. The present study demonstrates the pervasive role of IL-8 in the malignant progression of ER-negative breast cancer. IL-8 siRNA inhibited proliferation and delayed the G1 to S cell cycle progression in MDA-MB-231 and BT549 cells. IL-8 silencing resulted in the upregulation of the CDK inhibitor p27, the downregulation of cyclin D1, and the reduction of phosphorylated-Akt and NF-κB activities. IL-8 depletion also increased the chemosensitivity to docetaxel. These results indicate a role for IL-8 in promoting tumor cell survival and resistance to docetaxel and highlight the potential therapeutic significance of IL-8 depletion in ER-negative breast cancer patients.

  18. Interleukin 6 promotes endometrial cancer growth through an autocrine feedback loop involving ERKNF-?B signaling pathway

    SciTech Connect

    Che, Qi; Liu, Bin-Ya; Wang, Fang-Yuan; He, Yin-Yan; Lu, Wen; Liao, Yun; Gu, Wei; Wan, Xiao-Ping

    2014-03-28

    Highlights: IL-6 could promote endometrial cancer cells proliferation. IL-6 promotes its own production through an autocrine feedback loop. ERK and NF-?B pathway inhibitors inhibit IL-6 production and tumor growth. IL-6 secretion relies on the activation of ERKNF-?B pathway axis. An orthotopic nude endometrial carcinoma model confirms the effect of IL-6. - Abstract: Interleukin (IL)-6 as an inflammation factor, has been proved to promote cancer proliferation in several human cancers. However, its role in endometrial cancer has not been studied clearly. Previously, we demonstrated that IL-6 promoted endometrial cancer progression through local estrogen biosynthesis. In this study, we proved that IL-6 could directly stimulate endometrial cancer cells proliferation and an autocrine feedback loop increased its production even after the withdrawal of IL-6 from the medium. Next, we analyzed the mechanism underlying IL-6 production in the feedback loop and found that its production and IL-6-stimulated cell proliferation were effectively blocked by pharmacologic inhibitors of nuclear factor-kappa B (NF-?B) and extra-cellular signal-regulated kinase (ERK). Importantly, activation of ERK was upstream of the NF-?B pathways, revealing the hierarchy of this event. Finally, we used an orthotopic nude endometrial carcinoma model to confirm the effects of IL-6 on the tumor progression. Taken together, these data indicate that IL-6 promotes endometrial carcinoma growth through an expanded autocrine regulatory loop and implicate the ERKNF-?B pathway as a critical mediator of IL-6 production, implying IL-6 to be an important therapeutic target in endometrial carcinoma.

  19. The CKM matrix and the unitarity triangle. Proceedings, workshop, Geneva, Switzerland, February 13-16, 2002

    SciTech Connect

    M. Battaglia et al.

    2004-04-02

    This report contains the results of the Workshop on the CKM Unitarity Triangle that was held at CERN on 13-16 February 2002. There had been several Workshops on B physics that concentrated on studies at e{sup +}e{sup -} machines, at the Tevatron, or at LHC separately. Here we brought together experts of different fields, both theorists and experimentalists, to study the determination of the CKM matrix from all the available data of K, D, and B physics. The analysis of LEP data for B physics is reaching its end, and one of the goals of the Workshop was to underline the results that have been achieved at LEP, SLC, and CESR. Another goal was to prepare for the transfer of responsibility for averaging B physics properties, that has developed within the LEP community, to the present main actors of these studies, from the B factory and the Tevatron experiments. The optimal way to combine the various experimental and theoretical inputs and to fit for the apex of the Unitarity Triangle has been a contentious issue. A further goal of the Workshop was to bring together the proponents of different fitting strategies, and to compare their approaches when applied to the same inputs. Since lattice QCD plays a very important role in the determination of the non-perturbative parameters needed to constrain the CKM unitarity triangle, the first Workshop was seen as an excellent opportunity to bring together lattice theorists with the aim of establishing a working group to compile averages for phenomenologically relevant quantities. Representatives from lattice collaborations around the world were invited to attend a meeting during the Workshop. A consensus was reached to set up three test working groups, collectively known as the ''CKM Lattice Working Group'', to review a number of well-studied quantities: quark masses, the kaon B-parameter, and the matrix elements relevant for neutral B-meson mixing. This report is organized as a coherent document with chapters covering the domains of activity of the working groups. It deals mainly with the present determination of the CKM matrix in the Standard Model with a brief outlook on the near future. The impact of future measurements and of physics beyond the Standard Model will be developed further in forthcoming Workshops with the same title. Indeed, the Workshop was conceived as the first of a series. The second one will take place on 5-9 April 2003 in Durham and will focus on the results from the B-factories.

  20. Ionic Liquid–Solute Interactions Studied by 2D NOE NMR Spectroscopy

    DOE PAGES [OSTI]

    Khatun, Sufia; Castner, Edward W.

    2014-11-26

    Intermolecular interactions between a Ru²⁺(bpy)₃ solute and the anions and cations of four different ionic liquids (ILs) are investigated by 2D NMR nuclear Overhauser effect (NOE) techniques, including {¹H-¹⁹F} HOESY and {¹H-¹H} ROESY. Four ILs are studied, each having the same bis(trifluoromethylsulfonyl)amide anion in common. Two of the ILs have aliphatic 1-alkyl-1-methylpyrrolidinium cations, while the other two ILs have aromatic 1-alkyl-3-methylimidazolium cations. ILs with both shorter (butyl) and longer (octyl or decyl) cationic alkyl substituents are studied. NOE NMR results suggest that the local environment of IL anions and cations near the Ru²⁺(bpy)₃ solute is rather different from the bulkmore » IL structure. The solute-anion and solute-cation interactions are significantly different both for ILs with short vs long alkyl tails and for ILs with aliphatic vs aromatic cation polar head groups. In particular, the solute-anion interactions are observed to be about 3 times stronger for the cations with shorter alkyl tails relative to the ILs with longer alkyl tails. The Ru²⁺(bpy)₃ solute interacts with both the polar head and the nonpolar tail groups of the 1- butyl-1-methylpyrrolidinium cation but only with the nonpolar tail groups of the 1-decyl-1-methylpyrrolidinium cation.« less

  1. Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro

    SciTech Connect

    Rubin, L.A.; Kurman, C.C.; Fritz, M.E.; Biddison, W.E.; Boutin, B.; Yarchoan, R.; Nelson, D.L.

    1985-11-01

    With the use of an enzyme-linked immunoabsorbent assay to measure soluble human interleukin 2 receptors (IL 2R), certain human T cell leukemia virus I (HTLV I)-positive T cell lines were found to spontaneously release large quantities of IL 2R into culture supernatants. This was not found with HTLV I-negative and IL 2 independent T cell lines, and only one of seven B cell-derived lines examined produced small amounts of IL 2R. In addition to this constitutive production of soluble IL 2R by certain cell lines, normal human peripheral blood mononuclear cells (PBMC) could be induced to release soluble IL 2R by plant lectins, the murine monoclonal antibody OKT3, tetanus toxoid, and allogeneic cells. Such activated cells also expressed cellular IL 2R measurable in detergent solubilized cell extracts. The generation of cellular and supernatant IL 2R was: dependent on cellular activation, rapid, radioresistant (3000 rad), and inhibited by cycloheximide treatment. NaDodSO4-polyacrylamide gel electrophoresis analysis of soluble IL 2R demonstrated molecules of apparent Mr = 35,000 to 40,000, and 45,000 to 50,000, respectively, somewhat smaller than the mature surface receptor on these cells. The release of soluble IL 2R appears to be a characteristic marker of T lymphocyte activation and might serve an immunoregulatory function during both normal and abnormal cell growth and differentiation.

  2. Human interleukin 2 receptor. beta. -chain gene: Chromosomal localization and identification of 5 prime regulatory sequences

    SciTech Connect

    Gnarra, J.R.; Otani, Hiroki; Wang, M.G.; McBride, O.W.; Sharon, M.; Leonard, W.J. )

    1990-05-01

    Interleukin 2 (IL-2) binds to and stimulates activated T cells through high-affinity IL-2 receptors (IL-2Rs). Such receptors represent a complex consisting of at least two proteins, the 55-kDa IL-2R{alpha} chain and the 70-kDa IL-2R{beta} chain. The low-affinity, IL-2R{alpha} chain cannot by itself transduce a mitogenic signal, whereas IL-2 stimulates resting lymphocytes through the intermediate-affinity, IL-2R{beta} receptor. The authors report here identification of the genomic locus for IL-2R{beta}. The exons are contained on four EcoRI fragments of 1.1, 9.2, 7.2, and 13.7 kilobases. The 1.1-kilobase EcoRI fragment lies at the 5{prime}-most end of the genomic locus and contains promoter sequences. The promoter contains no TATA box-like elements but does contain the d(GT){sub n} class of middle repetitive elements, which may play an interesting regulatory role. The IL-2R{beta} gene is localized to chromosome 22q11.2-q12, a region that is the locus for several lymphoid neoplasias.

  3. Ionic Liquid–Solute Interactions Studied by 2D NOE NMR Spectroscopy

    SciTech Connect

    Khatun, Sufia; Castner, Edward W.

    2014-11-26

    Intermolecular interactions between a Ru²⁺(bpy)₃ solute and the anions and cations of four different ionic liquids (ILs) are investigated by 2D NMR nuclear Overhauser effect (NOE) techniques, including {¹H-¹⁹F} HOESY and {¹H-¹H} ROESY. Four ILs are studied, each having the same bis(trifluoromethylsulfonyl)amide anion in common. Two of the ILs have aliphatic 1-alkyl-1-methylpyrrolidinium cations, while the other two ILs have aromatic 1-alkyl-3-methylimidazolium cations. ILs with both shorter (butyl) and longer (octyl or decyl) cationic alkyl substituents are studied. NOE NMR results suggest that the local environment of IL anions and cations near the Ru²⁺(bpy)₃ solute is rather different from the bulk IL structure. The solute-anion and solute-cation interactions are significantly different both for ILs with short vs long alkyl tails and for ILs with aliphatic vs aromatic cation polar head groups. In particular, the solute-anion interactions are observed to be about 3 times stronger for the cations with shorter alkyl tails relative to the ILs with longer alkyl tails. The Ru²⁺(bpy)₃ solute interacts with both the polar head and the nonpolar tail groups of the 1- butyl-1-methylpyrrolidinium cation but only with the nonpolar tail groups of the 1-decyl-1-methylpyrrolidinium cation.

  4. Molecular mechanisms of ionic liquid cytotoxicity probed by an integrated experimental and computational approach

    DOE PAGES [OSTI]

    Yoo, Brian; Jing, Benxin; Jones, Stuart E.; Lamberti, Gary A.; Zhu, Yingxi; Shah, Jindal K.; Maginn, Edward J.

    2016-02-02

    Ionic liquids (ILs) are salts that remain liquid down to low temperatures, and sometimes well below room temperature. ILs have been called “green solvents” because of their extraordinarily low vapor pressure and excellent solvation power, but ecotoxicology studies have shown that some ILs exhibit greater toxicity than traditional solvents. A fundamental understanding of the molecular mechanisms responsible for IL toxicity remains elusive. Here we show that one mode of IL toxicity on unicellular organisms is driven by swelling of the cell membrane. Cytotoxicity assays, confocal laser scanning microscopy, and molecular simulations reveal that IL cations nucleate morphological defects in themore » microbial cell membrane at concentrations near the half maximal effective concentration (EC50) of several microorganisms. Lastly, cytotoxicity increases with increasing alkyl chain length of the cation due to the ability of the longer alkyl chain to more easily embed in, and ultimately disrupt, the cell membrane.« less

  5. Tertiary and Quaternary Ammonium-Phosphate Ionic Liquids as Lubricant Additives

    DOE PAGES [OSTI]

    Barnhill, William C.; Luo, Huimin; Meyer, III, Harry M; Ma, Cheng; Chi, Miaofang; Papke, Brian L.; Qu, Jun

    2016-06-23

    In this work we investigated the feasibility of five quaternary (aprotic) and four tertiary (protic) ammonium ionic liquids (ILs) with an identical organophosphate anion as lubricant antiwear additives. Viscosity, oil solubility, thermal stability, and corrosivity of the candidate ILs were characterized and correlated to the molecular structure. The protic group exhibits higher oil solubility than the aprotic group, and longer alkyl chains seem to provide better oil solubility and higher thermal stability. Selected ILs were applied as oil additives in steel-cast iron tribological tests and demonstrated promising anti-scuffing and anti-wear functionality. The thickness, nanostructure, coverage and composition of the tribofilmmore » formed by the besting performing IL were revealed by surface characterization for mechanistic understanding of the tribochemical interactions between the IL and metal surface. Results provide fundamental insights of the correlations among the molecular structure, physiochemical properties and lubricating performance for ammonium-phosphate ILs.« less

  6. Slide 1

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Illinois, Champaign, IL October 14-16, 2008 ARM AVP Workshop The Profiling Radiometer for Atmospheric and Cloud Observation PRACO Marian Klein, Vladimir Irisov, Vladimir Leuski University of Illinois, Champaign, IL October 14-16, 2008 ARM AVP Workshop BEST * Established in 2006 * Passive microwave remote sensing * Long experience with airborne, ship-borne, ground based microwave radiometers University of Illinois, Champaign, IL October 14-16, 2008 ARM AVP Workshop 60 GHz Boundary Layer

  7. Reduced Parasite Burden in Children with Falciparum Malaria and Bacteremia Coinfections: Role of Mediators of Inflammation

    DOE PAGES [OSTI]

    Davenport, Gregory C.; Hittner, James B.; Otieno, Vincent; Karim, Zachary; Mukundan, Harshini; Fenimore, Paul W.; Hengartner, Nicolas W.; McMahon, Benjamin H.; Kempaiah, Prakasha; Ong’echa, John M.; et al

    2016-01-01

    Bmore » acteremia and malaria coinfection is a common and life-threatening condition in children residing in sub-Saharan Africa. We previously showed that coinfection with Gram negative (G[−]) entericacilli and Plasmodium falciparum ( Pf [+]) was associated with reduced high-density parasitemia (HDP, >10,000 parasites/ μ L), enhanced respiratory distress, and severe anemia. Since inflammatory mediators are largely unexplored in such coinfections, circulating cytokines were determined in four groups of children ( n = 206 , aged <3 yrs): healthy; Pf [+] alone; G[−] coinfected; and G[+] coinfected. Staphylococcus aureus and non-Typhi Salmonella were the most frequently isolated G[+] and G[−] organisms, respectively. Coinfected children, particularly those with G[−] pathogens, had lower parasite burden (peripheral and geometric mean parasitemia and HDP). In addition, both coinfected groups had increased IL-4, IL-5, IL-7, IL-12, IL-15, IL-17, IFN- γ , and IFN- α and decreased TNF- α relative to malaria alone. Children with G[−] coinfection had higher IL-1 β and IL-1Ra and lower IL-10 than the Pf [+] group and higher IFN- γ than the G[+] group. To determine how the immune response to malaria regulates parasitemia, cytokine production was investigated with a multiple mediation model. Cytokines with the greatest mediational impact on parasitemia were IL-4, IL-10, IL-12, and IFN- γ . Results here suggest that enhanced immune activation, especially in G[−] coinfected children, acts to reduce malaria parasite burden.« less

  8. Workplace Charging Challenge Partner: Schneider Electric | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energy Schneider Electric Workplace Charging Challenge Partner: Schneider Electric Workplace Charging Challenge Partner: Schneider Electric Joined the Challenge: March 2013 Headquarters: Palatine, IL Charging Locations: Cedar Rapids, IA; Palatine, IL; O'Fallon, MO; Des Plaines, IL; Knightdale, NC; West Kingston, RI; North Andover, MA; Billerica, MA; Nashville, TN; LaVergne, TN; Smryna, TN; Clovis, CA; Costa Mesa, CA; Carrollton, TX; Seneca, SC; Lexington, KY; Detroit, MI Domestic Employees:

  9. Antigen-specific murine T cell clones produce soluble interleukin 2 receptor on stimulation with specific antigens

    SciTech Connect

    Wagner, D.K.; York-Jolley, J.; Malek, T.R.; Berzofsky, J.A.; Nelson, D.L.

    1986-07-15

    In this study, monoclonal antibodies were used to the murine IL 2 receptor (IL 2R) termed 3C7 and 7D4, which bind to different epitopes on the murine IL 2R, to develop an ELISA to measure soluble murine IL 2R. Surprisingly, stimulated murine spleen cells not only expressed cell-associated IL 2R, but also produced a considerable level of cellfree IL 2R in the culture supernatant fluid. To assess the fine specificity of this response, myoglobin-immune murine T cell clones were stimulated with appropriate or inappropriate antigen and syngeneic or allogeneic presenting cells. Proliferation, measured by (/sup 3/H) thymidine incorporation, and levels of soluble IL 2R were determined at day 4. The production of soluble IL2R displayed the same epitope fine specificity, genetic restriction, and antigen dose-response as the proliferative response. Indeed, in some cases there was sharper discrimination of epitope specificity and genetic restriction with the soluble IL 2R levels. There was also reproducible clone-to-clone variation in the amount of soluble receptor produced in response to antigen among 12 T cell clones and lines tested. In time course experiments, proliferation was greatest at day 3, whereas soluble IL 2R levels continued to rise in subsequent days. To the authors' knowledge, this is the first demonstration of release of secretion of soluble IL 2R by murine T cells, and the first demonstration of the fine specificity and genetic restriction of the induction of soluble IL 2R by specific antigen.

  10. Microsoft PowerPoint - Kumar_2015_CNMSUserProjectHighlight_Nanoscale...

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    which can be significantly different from those observed in conventional polyelectrolytes. Strong electrostatic correlations in PolyILs tend to enhance the effects of...

  11. Brian K. Radak | Argonne Leadership Computing Facility

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  12. Huihuo Zheng | Argonne Leadership Computing Facility

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    Huihuo Zheng Postdoctoral Appointee Argonne National Laboratory 9700 S. Cass Avenue Building 240 - Wkstn. 1D16 Argonne, IL 60439 630-252-8643 huihuo.zheng

  13. Ira Goldberg | Argonne Leadership Computing Facility

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    Ira Goldberg Finance Ira Goldberg Argonne National Laboratory 9700 South Cass Avenue Building 240 - Rm. 2133 Argonne, IL 60439 630-252-8500 i

  14. Jared Punzel | Argonne Leadership Computing Facility

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    Jared Punzel HPC Systems Administration Associate Argonne National Laboratory 9700 S. Cass Avenue Building 240 - Wkstn. 1D20 Argonne, IL 60439 630-252-5030 jpunzel

  15. Jeffrey D. Emberson | Argonne Leadership Computing Facility

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    Jeffrey D. Emberson Postdoctoral Appointee Argonne National Laboratory 9700 S. Cass Avenue Building 240 - Wkstn. 2C6 Argonne, IL 60439 630-252-5770 jemberson

  16. Jessica Amacher | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Jessica Amacher ESH Coordinator Argonne National Laboratory 9700 S. Cass Avenue Bldg. 240 - Wkstn. 4C7 Argonne, IL 60439 630-252-4471 amacher

  17. Joan Stover | Argonne Leadership Computing Facility

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    Joan Stover Administrative Secretary Argonne National Laboratory 9700 South Cass Avenue Building 240 - Wkstn. 1D29 Argonne, IL 60439 630-252-0212 jstover

  18. Jon Bouvet | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Jon Bouvet Cray Consultant Argonne National Laboratory 9700 S. Cass Avenue Building 240 - Wkstn. 2D20 Argonne, IL 60439 630-252-6175 jbouvet

  19. DOE - Office of Legacy Management -- Museum of Science and Industry...

    Office of Legacy Management (LM)

    Documents Related to MUSEUM OF SCIENCE AND INDUSTRY IL.03-1 - Report (DOEEV-0000513) Formerly Utilized MEDAEC Sites Remedial Action Program Radiological Survey of the Museum of ...

  20. A striking effect of ionic-liquid anions in the extraction of Sr2+ and Cs+ by dicyclohexano-18-crown-6

    SciTech Connect

    Luo, Huimin; Dai, Sheng; Bonnesen, Peter V; Haverlock, Tamara; Moyer, Bruce A; Buchanan III, A C

    2006-01-01

    The nature of the ionic-liquid (IL) anion has been found to have a remarkable effect on the solvent extraction of Sr2+ and Cs+ by dicyclohexano-18-crown-6 dissolved in ionic liquids. In particular, the extraction efficiency increases with the hydrophobicity of the IL anion as reflected by the solubility in water of ILs having a common cation. Since a cation-exchange mechanism is operating in these systems, the influence of the IL anion is in large part attributable to an expected Le Chatelier effect in which a greater aqueous concentration of IL cation, obtained when using an IL anion of lower hydrophobicity, opposes cation exchange. This dependence is opposite to that found for IL cations, indicating a significant advantage of using ILs with hydrophobic anions for cation extraction. Furthermore, the extraction selectivity for Sr2+ over Na+, K+, and Cs+ can be significantly improved through the use of hydrophobic anions for the ILs containing 1-ethyl-3-methylimidazolium or 1-butyl-3-methylimidazolium cations.

  1. Magnetic properties of GdT2Zn20 (T = Fe, Co) investigated by...

    Office of Scientific and Technical Information (OSTI)

    Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany) Argonne National Lab. (ANL), Argonne, IL (United States) Univ. Federal do ABC (UFABC), Sao Paulo (Brazil) Univ. Estadual ...

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  3. Structure of a putative ClpS N-end rule adaptor protein from...

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    Argonne, IL (US) Sponsoring Org: UNIVERSITY Country of Publication: United States Language: ENGLISH Word Cloud More Like This Full Text Journal Articles DOI: 10.1002pro.2868

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    IL' It 18 Henderson Avenue Joliet, Illinois The facility is now occupied by Altrachem, ... -- - -I-' o- -4: I 1 -..."?VT 1--.?-?-. +q --ze- - -.. +r*.,...Lz.. ...

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    Photon Source, Argonne, IL (United States) Atlanta Regional Office, Atlanta, GA (United States) Atmospheric System Research Bartlesville Project Office, OK (United...

  6. Lensless Imaging of Atomic Surface Structures via Ptychography...

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    Materials Science Division, Argonne National Laboratory, Argonne, IL Coherent x-ray diffraction imaging (CDI) is a lensless technique, which has been in rapid progress recently...

  7. Joe Sortino | Argonne Leadership Computing Facility

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    Joe Sortino Research Aide - VIZ Team Argonne National Laboratory 9700 S. Cass Avenue Building 240 - Wkstn. 4E7 Argonne, IL 60439 jsortino@anl...

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    Jie Jiang Research Aide - VIZ Team Argonne National Laboratory 9700 S. Cass Avenue Building 240 - Wkstn. 4E9A Argonne, IL 60439 jiejiang@anl...

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    Young Guest Researcher Argonne National Laboratory 9700 S. Cass Avenue Building 240 Wkstn. 4D15 Argonne, IL 60439 younga@anl...

  10. Characteristics of Lamellar Mesophases in Strongly Segregated...

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    Argonne, IL (US) Sponsoring Org: NSFUNIVERSITY Country of Publication: United States Language: ENGLISH Word Cloud More Like This Full Text Journal Articles DOI: 10.1021ma5006233...

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    external clients) access to State-of-the-Art genomics capabilities: next generation ... Research Org: FNAL (Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United ...

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    Underground Storage Volume (MMcf)" ,"Click worksheet name or tab at bottom for data" ...dnavnghistn5030il2m.htm" ,"Source:","Energy Information Administration" ,"For Help, ...

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    Association of the Remodeling Industry (NARI) Jump to: navigation, search Name: National Association of the Remodeling Industry (NARI) Place: Des Plaines, IL Website: www.nari.org...

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    Joseph A. Insley Principal Software Development Specialist Joe Insley Argonne National Laboratory 9700 South Cass Avenue Building 240 - Rm. 4140 Argonne, IL 60439 630-252-5649...

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    Accelerator Conference (APAC 2007) (Jan. 29-Feb. 2) Indore, India APS Upgrade ERL Optics Workshop (April 23) Argonne National Laboratory, Argonne, IL Synchrotron Radiation...

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    Laboratory, Argonne, IL May 17-21 Conference on Advanced Phase Measurement Methods in Optics and Imaging, with Special Sessions for X-ray Methods Monte Verita, Locarno,...

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    LLC Jump to: navigation, search Name: Center Ethanol Company LLC Place: Illinois Product: Illinois based company building a 54m gallon ethanol plant in Sauget, IL. References:...

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    Heat Pump Water Heater Technology Assessment Based on Laboratory Research and Energy Simulation Models. 2012 ASHRAE Winter Conference, Chicago, IL, January 21-25, 2012. NREL Report ...

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    ECOR VAP Flux Corrections, Gap-filling, and Results David R. Cook, Meredith Franklin, Donna J. Holdridge Argonne National Laboratory, Argonne, IL This work was supported by the...

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    Commercialized Technologies and Significant Research Accomplishments O il and natural gas are the lifeblood of our economy, accounting for roughly 62 percent of the energy consumed ...

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    Type Community Wind Facility Status In Service Owner City of Geneseo Developer Johnson Controls City of Geneseo Location Geneseo IL Coordinates 41.42597968,...

  9. Saumil Patel | Argonne Leadership Computing Facility

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  7. Better Buildings Residential Network Workforce/Business Partners...

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    IL * New Orleans, LA * Maryland * University Park, MD * Michigan * Kansas City, MO * Omaha and Lincoln, NE * New Hampshire * New York * Cincinnati, OH * Rutland County, VT * ...

  8. Program Sustainability Peer Exchange Call: Lender-based Revenues...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    County, CO * Cincinnati, OH * Chicago, IL * Michigan * Los Angeles County, CA * Omaha and Lincoln, NE * Sacramento, CA * Kansas City, MO CEWO EVOLUTION 2009-2011 ...

  9. Other Participants 1996 | U.S. DOE Office of Science (SC)

    Office of Science (SC)

    Cloud , MN Classical High School, Providence , RI Creighton Preparatory School , Omaha , NE Crystal Lake South High School , Crystal Lake , IL Custer County District High School , ...

  10. Rapid Cycling Synchrotron Option for Project X (Conference) ...

    Office of Scientific and Technical Information (OSTI)

    Org: Fermi National Accelerator Laboratory (FNAL), Batavia, IL Sponsoring Org: USDOE Country of Publication: United States Language: English Subject: 71 CLASSICAL AND QUANTUM ...

  11. State Farm Insurance | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Farm Insurance Jump to: navigation, search Name: State Farm Insurance Place: Bloomington, IL Website: www.statefarminsurance.com References: State Farm Insurance1 Information...

  12. Spin valve with non-collinear magnetization configuration imprinted...

    Office of Scientific and Technical Information (OSTI)

    Material Science Division, Argonne National Laboratory, Argonne, IL 60439, USA, Department of Physics and Astronomy, Texas A&M University, College Station, TX 77843-4242, USA ...

  13. Superior Energy Performance: Certifying Increased Energy Productivity...

    Energy.gov [DOE] (indexed site)

    ... years + 30 Best Practice Scorecard points Gold 10% energy performance improvement over 3 ... 2) Schneider Electric Columbia, MO GOLD SILVER 3M Company Cordova, IL MedImmune ...

  14. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Laboratory-Advanced Photon Source, Argonne, IL ... the crystallographic position (13, 23, 34) is ... According to single crystal X-ray diffraction data BaLisub ...

  15. Renee Plzak | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Renee Plzak Administrative Secretary Argonne National Laboratory 9700 S. Cass Avenue Building 240 - Wkstn. 3D24 Argonne, IL 60439 630-252-3556 rplzak@anl.gov

  16. Separation of Fission Products Based on Ionic Liquids: Anion Effect

    SciTech Connect

    Luo, Huimin; Dai, Sheng; Bonnesen, Peter V.

    2004-03-28

    The applications of ionic liquids (ILs) as new separation media have been actively investigated recently. The most commonly studied class of ILs for such applications is based on dialkyl imidazolium cations. In comparison with conventional molecular solvents, ILs exhibit enhanced distribution coefficients for a number of complexing neutral ligands in extraction of metal ions from aqueous solutions. The effect of the alkyl chain length of imidazolium cations on the distribution coefficients of solvent extraction using crown ethers was the subject of a number of the previous investigations. The distribution coefficients have been found to decrease with the alkyl chain length of the IL cations. This observation implies that the extraction process also involves the exchange of the IL cations with metal ions. The longer the alkyl chain lengths of the IL cations are, the more hydrophobic the IL cations are and the more difficult to be transported into aqueous phases via ion exchange. Accordingly, the ion-exchange process is another unique property of IL-based extractions involving charged species. Here, we report the investigation about the effect of the variation of IL anions on the solvent extraction of metal ions using crown ethers as extractants. The elucidation of different solvation effects involved in ionic liquids could lead to optimized separation media for these novel solvents.

  17. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    States) Chicago Regional Office, Chicago, IL (United States) Clinch River Breeder Reactor Project, Oak Ridge, TN (United States) DOE HSS Office of Classification, Office of...

  18. Defining the functional determinants for RNA surveillance by...

    Office of Scientific and Technical Information (OSTI)

    Defining the functional determinants for RNA surveillance by RIG-I Citation Details ... Research Org: Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL ...

  19. Grand Ridge II Wind Farm | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Owner Invenergy Developer Invenergy Energy Purchaser AEP-Appalachian Power Location La Salle County IL Coordinates 41.15496, -88.750234 Show Map Loading map......

  20. Grand Ridge III Wind Farm | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Owner Invenergy Developer Invenergy Energy Purchaser AEP-Appalachian Power Location La Salle County IL Coordinates 41.15496, -88.750234 Show Map Loading map......

  1. Grand Ridge Wind Farm | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Scale Wind Facility Status In Service Owner Invenergy Developer Invenergy Location La Salle County IL Coordinates 40.999966, -88.401693 Show Map Loading map......

  2. Vestas USA | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    USA Jump to: navigation, search Name: Vestas USA Place: Rolling Meadows, Illinois Zip: IL 60008-4030 Sector: Wind energy Product: Vestas Wind Systems American arm. References:...

  3. Adrian C. Pope | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Adrian C. Pope Assistant Computational Scientist Argonne National Laboratory 9700 S. Cass Avenue Building 240 - Rm. 11213 Argonne, IL 60439 630-252-8745 apope@anl

  4. Anouar Benali | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Anouar Benali Assistant Computational Scientist Anouar Benali Argonne National Laboratory 9700 South Cass Avenue Building 240 - Rm. 2127 Argonne, IL 60439 630-252-0058 benali@anl

  5. Ashley Boyle | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Ashley Boyle Administrative Secretary Argonne National Laboratory 9700 South Cass Avenue Building 240 - Wkstn. 3D16 Argonne, IL 60439 630-252-1385 aboyle@anl

  6. Ben Allen | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Ben Allen HPC Systems Administration Specialist Argonne National Laboratory 9700 South Cass Avenue Building 240 - Rm. 2128 Argonne, IL 60439 630-252-0554 allen

  7. Beth Cerny | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Beth Cerny Communications Lead Beth Cerny Patino Argonne National Laboratory 9700 S. Cass Avenue Building 240 - Rm. 2132 Argonne, IL 60439 630-252-1100 bcerny

  8. Bill Allcock | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Bill Allcock Manager, Advanced Integration Group Bill Allcock Argonne National Laboratory 9700 South Cass Avenue Building 240 - Rm 1127 Argonne, IL 60439 630-252-7573 allcock

  9. Brian Toonen | Argonne Leadership Computing Facility

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    Brian Toonen Consultant/Software Engineer Argonne National Laboratory 9700 South Cass Avenue Building 240 - Rm. 3123 Argonne, IL 60439 630-252-6722 toonen

  10. Illinois Wind Energy | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Wind Energy Jump to: navigation, search Name: Illinois Wind Energy Place: Chicago, Illinois Zip: IL 60606 Sector: Wind energy Product: Developer of wind power generating facilities...

  11. EV Everywhere Batteries Workshop- Materials Processing and Manufacturing Breakout Session Report

    Energy.gov [DOE]

    Breakout session presentation for the EV Everywhere Grand Challenge: Battery Workshop on July 26, 2012 held at the Doubletree O'Hare, Chicago, IL.

  12. Long life lithium batteries with stabilized electrodes (Patent...

    Office of Scientific and Technical Information (OSTI)

    Inventors: Amine, Khalil ; Liu, Jun ; Vissers, Donald R ; Lu, Wenquan Issue Date: 2015-04-21 OSTI Identifier: 1178256 Assignee: UChicago Argonne, LLC (Chicago, IL) CHO Patent ...

  13. DOE Zero Energy Ready Home Case Study: Weiss Building & Development LLC,

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    System Home, River Forest, IL | Department of Energy Weiss Building & Development LLC, System Home, River Forest, IL DOE Zero Energy Ready Home Case Study: Weiss Building & Development LLC, System Home, River Forest, IL Case study of a DOE Zero Energy Ready Home in River Forest, IL, that scored HERS 17 without PV. This 4,763-square-foot custom passive house has R-54 ICF walls, a vented attic with R-100 blown fiberglass, plus R-40 rigid EPS under the slab, triple-pane windows, two

  14. DOE Zero Energy Ready Home Case Study: Weiss Building & Development LLC.,

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Custom Home, Downers Grove, IL | Department of Energy DOE Zero Energy Ready Home Case Study: Weiss Building & Development LLC., Custom Home, Downers Grove, IL DOE Zero Energy Ready Home Case Study: Weiss Building & Development LLC., Custom Home, Downers Grove, IL Case study of a DOE Zero Energy Ready Home in Downers Grove, IL, that scored HERS 35 without PV. This 3,600-square-foot custom home has advanced framed walls with R-23 dense-packed fiberglass plus R-13 rigid polyiso, a

  15. DARK MATTER HALO PROFILES OF MASSIVE CLUSTERS: THEORY VERSUS...

    Office of Scientific and Technical Information (OSTI)

    Argonne, IL 60439 (United States) Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States) Harvard-Smithsonian Center for Astrophysics, ...

  16. EV Everywhere Batteries Workshop- Pack Design and Optimization Breakout Session Report

    Energy.gov [DOE]

    Breakout session presentation for the EV Everywhere Grand Challenge: Battery Workshop on July 26, 2012 held at the Doubletree O'Hare, Chicago, IL.

  17. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    International Laboratory of Materials Science and Nanotechnology" Name Name ORCID Search ... States) Argonne National Laboratory-Advanced Photon Source, Argonne, IL (United ...

  18. User:Hakan28 | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    illerden gelen insanlar ile birlikte Mudanya'nn nfusu ve geliimi artyor. Bursa inaat Bursa Marmara Blgesi'nin stanbul'dan sonraki en nemli il sralamasnda...

  19. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    ... by gene up-regulation of tumor necrosis factor- (TNF-), interleukin-1 (IL-1), ... and in hadron-nucleon collisions dsigmasup hAdqsub Tsup 2dsigmasup ...

  20. Latest Documents and Notices | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Hawaii Clean Energy Programmatic Environmental Impact Statement September 15, 2015 EA-1975: Supplement Analysis LINAC Coherent Light Source-Il, SLAC National Accelerator...

  1. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    IL (United States) Clinch River Breeder Reactor Project, Oak Ridge, TN (United States) ... long-standing predictions of dimensional scaling of high-energy amplitudes using quark ...

  2. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    IL (United States) Clinch River Breeder Reactor Project, Oak Ridge, TN (United States) ... predictions of dimensional scaling of high-energy amplitudes using quark counting. ...

  3. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    IL (United States) Clinch River Breeder Reactor Project, Oak Ridge, TN (United States) ... , American Physical Society Coordinate scaling in time-dependent current-density-functio...

  4. Host galaxy spectra and consequences for supernova typing from...

    Office of Scientific and Technical Information (OSTI)

    ... Fermi National Accelerator Laboratory, P.O. Box 500, Batavia, IL 60510 (United States) Institut de Fsica d'Altes Energies, Universitat Autnoma de Barcelona, E-08193 ...

  5. m QUANTUM CHAOS IN AHARONOV-BOHM OSCILLATIONS Gennady P. Berman...

    Office of Scientific and Technical Information (OSTI)

    Illinois at Urbana-Champaign, 1110 West Green St., Urbana, IL 'Kirensky Institute of ... We investigate the oscillations of the time-averaged electron energy at zero temperature ...

  6. Transcendental Meditation

    ScienceCinema

    None

    2016-07-12

    K.Wallace, qui vient des Etats Unis, parle des effects physiologiques de la méditation transcendantale. Il a fait son bachelor en physique à l'Université de Los Angeles et son doctorat en physiologie aussi à Los Angeles, mais à l'Institut de Recherche sur le cerveau. Il travaille maintenat à Harvard Medical School ou il continue des recherches biochimiques et physiologiques sur l'application médicale de la méditation transcendantale. Il s'occupe principalement des maladies cardiaques et de hypertension artérielle.

  7. Marquis Energy LLC | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Name: Marquis Energy LLC Place: Hennepin, Illinois Zip: 61327 Product: A Babcock & Brown company organized to build and operate a 100m gallon ethanol plant in Hennepin, IL....

  8. GSG Wind Farm | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    energy Facility Type Commercial Scale Wind Facility Status In Service Owner Babcock & Brown Developer FPC Services Location Lee and LaSalle Counties IL Coordinates 41.710895,...

  9. Randolph Eastern School Corporation | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Sector Wind energy Facility Type Community Wind Facility Status In Service Owner Performance Services Energy Purchaser AEP - Indiana Michigan Power Location Union City IL...

  10. The City of Union City | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Sector Wind energy Facility Type Community Wind Facility Status In Service Owner Performance Services Energy Purchaser AEP - Indiana Michigan Power Location Union City IL...

  11. EV Everywhere Grand Challenge- Battery Status and Cost Reduction Prospects

    Office of Energy Efficiency and Renewable Energy (EERE)

    Presentation given by technology manager David Howell at the EV Everywhere Grand Challenge: Battery Workshop on July 26, 2012 held at the Doubletree O'Hare, Chicago, IL.

  12. A 5;#8242; cytosine binding pocket in Puf3p specifies regulation...

    Office of Scientific and Technical Information (OSTI)

    Argonne, IL (US) Sponsoring Org: NIH Country of Publication: United States Language: ENGLISH Word Cloud More Like This Full Text Journal Articles DOI: 10.1073pnas.0812079106...

  13. Atlas Material Testing Solutions | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Atlas Material Testing Solutions Jump to: navigation, search Name: Atlas Material Testing Solutions Place: Chicago, IL Zip: 60613 Website: atlas-mts.com Coordinates: 41.9529209,...

  14. Towards a Large-Scale Recording System: Demonstration of Polymer...

    Office of Scientific and Technical Information (OSTI)

    Resource Relation: Conference: Presented at: 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Chicago, IL, United States, Aug 26 - Aug ...

  15. 15-CS-1035 ESnet EuropeUS Map_EEX_v4

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Office of Science National Labs Ames ANL BNL FNAL JLAB Ames Laboratory (Ames, IA) Argonne National Laboratory (Argonne, IL) Brookhaven National Laboratory (Upton, NY) Fermi...

  16. Search for: All records | SciTech Connect

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    for Plutonium, Amarillo, TX (United States) AmeriFlux Ames Laboratory (AMES), Ames, IA (United States) Argonne National Laboratory (ANL), Argonne, IL (United States) Argonne...

  17. Kairos Consulting Worldwide Wins HUBZone Business of the Year Award at Small Business Forum & Expo

    Energy.gov [DOE]

    Kairos Consulting Worldwide, Chicago, IL, won the HUBZone Business of the Year Award at the Small Business Forum & Expo in Tampa, FL, on July 12, 2014.

  18. Providence Heights Wind Farm | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Status In Service Owner Iberdrola Renewables Developer Midwest Wind Energy Location Bureau County IL Coordinates 41.264075, -89.580853 Show Map Loading map......

  19. TITLE AUTHORS SUBJECT SUBJECT RELATED DESCRIPTION PUBLISHER AVAILABILI...

    Office of Scientific and Technical Information (OSTI)

    Cass Avenue HEP Argonne IL United States E mail zachos anl gov CLASSICAL AND QUANTUM MECHANICS GENERAL PHYSICS COMPACTIFICATION DUALITY FERMIONS GAUGE INVARIANCE HOLOGRAPHY MANY...

  20. Christopher T. [Fermi National Accelerator Laboratory, P.O. Box...

    Office of Scientific and Technical Information (OSTI)

    IL 60439-4815 (United States), E-mail: zachos@anl.gov 71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; COMPACTIFICATION; DUALITY; FERMIONS; GAUGE INVARIANCE; HOLOGRAPHY;...

  1. Archer Daniels Midland | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Daniels Midland Address: 4666 Faries Parkway Place: Decatur, IL Zip: 62526 Sector: Biofuels Product: turn crops into renewable products Phone Number: 800-637-5843 Website:...

  2. Ionic Liquids as Engine Lubricant Additives, Impact on Emission...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ... baseline - IL: ionic liquid lubricant-additive - ZDDP: ... rod end bushingsbearings), are to be studied. * ... electrons than a neutral metal, thus a softer base); - ...

  3. Low-Cost Gas Heat Pump For Building Space Heating | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Credit: Stone Mountain Technologies Lead Performer: Stone Mountain Technologies - Erwin, TN Partners: -- A.O. Smith - Milwaukee, WI -- Gas Technology Institute - Des Plaines, IL ...

  4. Enrico Fermi Achieves First Self Sustain Nuclear Chain Reaction...

    National Nuclear Security Administration (NNSA)

    Self Sustain Nuclear Chain Reaction Chicago, IL Metallurgical Laboratory scientists led by Enrico Fermi achieve the first self-sustained nuclear chain reaction in pile...

  5. The Midwest Energy Efficiency Alliance | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Midwest Energy Efficiency Alliance Jump to: navigation, search Name: The Midwest Energy Efficiency Alliance Place: Chicago, IL Information About Partnership with NREL Partnership...

  6. Functional electrolyte for lithium-ion batteries (Patent) | DOEPatents

    Office of Scientific and Technical Information (OSTI)

    Inventors: Zhang, Lu ; Zhang, Zhengcheng ; Amine, Khalil Issue Date: 2015-04-14 OSTI Identifier: 1178010 Assignee: UChicago Argonne, LLC (Chicago, IL) ANL Patent Number(s): ...

  7. DOE - Office of Legacy Management -- Fansteel Metallurgical Corp...

    Office of Legacy Management (LM)

    Daley; Subject: Fansteel Metallurgical Corp. Information; January 13, 1995 IL.16-3 - MemorandumChecklist; Young to the File; Subject: Elimination Recommendation; October 28, 1987...

  8. Structure and mechanism of activity-based inhibition of the EGF...

    Office of Scientific and Technical Information (OSTI)

    Authors: Park, Eunyoung ; Kim, Nayoung ; Ficarro, Scott B. ; Zhang, Yi ; Lee, Byung Il ; Cho, Ahye ; Kim, Kihong ; Park, Angela K.J. ; Park, Woong-Yang ; Murray, Bradley ; ...

  9. Introduction to computed microtomography and applications in...

    Office of Scientific and Technical Information (OSTI)

    Resource Relation: Related Information: CMS Workshop Lectures, Advanced Applications of Synchrotron Radiation in Clay Science Publisher: 2014; Tha Clay Minerals Society ;Urbana, IL ...

  10. Analytic Models for Pulsed X-Ray Impulse Coupling. (Conference...

    Office of Scientific and Technical Information (OSTI)

    on Shock Compression of Condensed Matter held June 26 - July 1, 2011 in Chicago, IL.; Related Information: Proposed for presentation at the 2011 APS Topical Conference on Shock ...

  11. Community and Economic Development Association of Cook County...

    OpenEI (Open Energy Information) [EERE & EIA]

    and Economic Development Association of Cook County (CEDA) Jump to: navigation, search Name: Community and Economic Development Association of Cook County (CEDA) Place: Chicago, IL...

  12. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    States) Chicago Operations Office, Argonne, IL ... Idaho National Engineering and Environmental Laboratory, Idaho ... and volume of the unit cell for orthorhombic ...

  13. Fermilab Today

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    IL Violinist Paolo Castellani and guitarist Francesco Di Giandomenico play the colorful music from Argentina, Spain and Puerto Rico. They will present their latest album,...

  14. PREPARATION OF DENSE URANIUM DIOXIDE PARTICLES FROM URANIUM HEXAFLUORI...

    Office of Scientific and Technical Information (OSTI)

    Research Org: Argonne National Lab., Argonne, IL (US) Sponsoring Org: US Atomic Energy ... HIGH TEMPERATURE; HYDROFLUORIC ACID; HYDROGEN; LAYERS; MIXING; PARTICLES; PREPARATION; ...

  15. Tribal Energy Program Student Internship Program

    Energy.gov [DOE] (indexed site)

    ... of Participation by Cultural Affairs - Chicago, IL 8 Photo by: Sandra Begay-Campbell CA Tribal Solar & W ind T our * Ramona Band of Cahuilla Indians * Ecotourism facility ...

  16. Bishop Hill II | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Owner MidAmerican Energy Developer Ivenergy Energy Purchaser Ameren Illinois Location Cambridge IL Coordinates 41.24438513, -90.09338379 Show Map Loading map......

  17. The Secretary of Energy

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    MEMORANDUM FOR HEADS OF DEPARTMENTAL ELEMENTS FROM: STEVEN CHU Il Subject: Enterprise Risk Management (ERM) Framework for Directives Thi s memorandum explains a new...

  18. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    IL (United States) Fernald Area Office (United States) Fernald Environmental Management Project, OH (United States) FluxNet General Atomics Site, San Diego, CA (United...

  19. OFFICE OF ELECTRICITY DELIVERY AND ENERGY RELIABILITY (OE)

    Office of Environmental Management (EM)

    ... Sections of Shell's Offshore Gulf pipeline have resumed operation and other ... (barrels day) Status Crude Capline Pipeline LA IL 1,200,000 Operating Crude Ho-Ho ...

  20. Michael D'Mello | Argonne Leadership Computing Facility

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    D'Mello Intel Consultant Argonne National Laboratory 9700 S. Cass Avenue Building 240 - Wkstn. 2D27 Argonne, IL 60439 mdmello@anl.gov

  1. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    ... and strontium from alkaline nitrate media simulating alkaline high level wastes ... Since a cation-exchange mechanism is operating in these systems, the influence of the IL ...

  2. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    IL (United States) Clinch River Breeder Reactor Project, Oak Ridge, TN (United States) ... processing a biomass in a hydropyrolysis reactor resulting in hydrocarbon fuels and a ...

  3. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    IL (United States) Clinch River Breeder Reactor Project, Oak Ridge, TN (United States) ... Optimization of multi-group cross sections for fast reactor analysis Chin, M. R. ; Manalo, ...

  4. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    IL (United States) Clinch River Breeder Reactor Project, Oak Ridge, TN (United States) ... Estimated radiactive and shock loading of fusion reactor armor Swift, D C Inertial ...

  5. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    IL (United States) Clinch River Breeder Reactor Project, Oak Ridge, TN (United States) ... Filter Results Filter by Subject gas coolant (7) reactor technology (6) reactors (6) fuel ...

  6. Observation of a Higgs-like Boson in CMS at the LHC (Conference...

    Office of Scientific and Technical Information (OSTI)

    Batavia, IL Sponsoring Org: DOE Office of Science Country of Publication: United States Language: English Subject: 72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS Experiment-HEP...

  7. Beam Loss Control for the Fermilab Main Injector (Conference...

    Office of Scientific and Technical Information (OSTI)

    Laboratory (FNAL), Batavia, IL Sponsoring Org: DOE Office of Science Country of Publication: United States Language: English Subject: 43 PARTICLE ACCELERATORS Accelerators...

  8. DOE - Office of Legacy Management -- Era Tool and Engineering...

    Office of Legacy Management (LM)

    personnel, facilities, and equipment to produce machined parts for special equipment, tools, jigs, fixtures, etc., from materials furnished by the University of Chicago IL.29-4 ...

  9. The Building Research Council at the University of Illinois ...

    OpenEI (Open Energy Information) [EERE & EIA]

    Research Council at the University of Illinois Jump to: navigation, search Name: The Building Research Council at the University of Illinois Place: Champaign, IL Information About...

  10. EV Everywhere Grand Challenge- Battery Workshop attendees list

    Energy.gov [DOE]

    Attendance list for the EV Everywhere Grand Challenge: Battery Workshop on July 26, 2012 held at the Doubletree O'Hare, Chicago, IL.

  11. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    IL (United States) Fernald Area Office (United States) Fernald Environmental Management Project, OH (United States) General Atomics Site, San Diego, CA (United States)...

  12. Validation and Application of the 3D Neutron Transport MPACT...

    Office of Scientific and Technical Information (OSTI)

    Resource Relation: Conference: NURETH-16. International Topical Meeting on Nuclear Reactor Hydraulics, Chicago, IL (United States), 30 Aug - 4 Sep 2015 Research Org: Oak Ridge ...

  13. Blending municipal solid waste with corn stover for sugar production...

    Office of Scientific and Technical Information (OSTI)

    applied an enzyme free process by adding mineral acid and water directly into the ILbiomass slurry to induce hydrolysis. With the acidolysis process in the IL...

  14. Non-aqueous electrolyte for lithium-ion battery (Patent) | DOEPatents

    Office of Scientific and Technical Information (OSTI)

    Inventors: Zhang, Lu ; Zhang, Zhengcheng ; Amine, Khalil Issue Date: 2014-04-15 OSTI Identifier: 1129197 Assignee: UChicago Argonne, LLC (Chicago, IL) ANL Patent Number(s): ...

  15. Electroactive materials for rechargeable batteries (Patent) ...

    Office of Scientific and Technical Information (OSTI)

    Inventors: Wu, Huiming ; Amine, Khalil ; Abouimrane, Ali Issue Date: 2015-04-21 OSTI Identifier: 1178258 Assignee: UChicago Argonne, LLC (Chicago, IL) CHO Patent Number(s): ...

  16. Redox shuttles for lithium ion batteries (Patent) | DOEPatents

    Office of Scientific and Technical Information (OSTI)

    Inventors: Weng, Wei ; Zhang, Zhengcheng ; Amine, Khalil Issue Date: 2016-03-22 OSTI Identifier: 1243310 Assignee: UCHICAGO ARGONNE, LLC (Chicago, IL) CHO Patent Number(s): ...

  17. United States Government

    Office of Legacy Management (LM)

    Davenport, IL Besley-Wells Co., Beloit, WI R. Brew Company, Concord, NH Cincinnati Hilling Machine, Cincinnati, DH (*) Fenwal, Ashland, UA Food Machining Corp., Nitro, WV General ...

  18. United States Government

    Office of Legacy Management (LM)

    Davenport, IL Besley-Wells Co., Beloit, YI R. Brew Company, Concord, NH Cincinnati Milling Hachine, Cincinnati, OH (*) Fenwal, Ashland, MA Food Machining Corp., Nitro, W General ...

  19. WSl

    Office of Legacy Management (LM)

    Davenport, IL Besley-Wells Co., Beloit, YI R. Brew Company, Concord, NH Cincinnati M illing Machine, Cincinnati, OH (*) Fenwal, Ashland, MA Food Machining Corp., Nitro, UV General ...

  20. EfG KMOJ- United States Government I@,&

    Office of Legacy Management (LM)

    Davenport, IL Besley-Wells Co., Beloit, W I II. Brew Company, Concord, NH Cincinnati Hilling Machine, Fenwal, Ashland, MA Cincinnati, OH (*) Food Machining Corp., Nitro, W V ...

  1. United States Government

    Office of Legacy Management (LM)

    Davenport, IL Besley-Wells Co., Beloit, WI innati, OH (*) R. Brew Coaopany, Concord; NH Cincinnati Milling Machine, Cihc Fenwal, Ashland, HA Food Machining Corp., Nitro, WV General ...

  2. DOE F

    Office of Legacy Management (LM)

    Davenport, IL Besley-Yells Co., Beloit, YI R. Brew Company, Concord, NH Cincinnati Milling Machine, Cincinnati, OH (*) Fenwal, Ashland, MA Food Machining Corp., Nitro, YV General ...

  3. United States Government

    Office of Legacy Management (LM)

    Davenport, IL Besley-Wells Co., Beloit, WI R. Brew Company, Concord, NH Cincinnati Milling Machine, Cincinnati, DH (*) Fenwal, Ashland, MA Food Machining Corp., Nitro, WV General ...

  4. I EFG Kww United States Government

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  4. Kathy DiBennardi | Argonne Leadership Computing Facility

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    Kathy DiBennardi Executive Secretary Argonne National Laboratory 9700 South Cass Avenue Building 240 - Wkstn. 4D11 Argonne IL, 60439 630-252-8600 dibennar...

  5. Paul Rich | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Rich Software Development Specialist Paul Rich Argonne National Laboratory 9700 South Cass Avenue Building 240 - Rm. 3126 Argonne, IL 60439 630-252-2430 richp@alcf.anl...

  6. Katrina Errant | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Katrina Errant Floor Manager Argonne National Laboratory 9700 S. Cass Avenue Building 240 - Wkstn. 3D18 Argonne, IL 60439 630-252-0024 kerrant...

  7. Janet Knowles | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Knowles Principal Software Development Specialist Argonne National Laboratory 9700 South Cass Avenue Building 240 - Rm. 3121 Argonne, IL 60439 630-252-6342 jknowles@alcf.anl...

  8. Piotr Zbiegiel | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Piotr Zbiegiel Senior Cyber Security Engineer Argonne National Laboratory 9700 South Cass Avenue Building 240 - Rm. 2122 Argonne, IL 60439 630-252-2939 pzbiegiel@anl...

  9. Hal Finkel | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Hal Finkel Assistant Computational Scientist Hal Finkel Argonne National Laboratory 9700 South Cass Avenue Building 240 - Rm. 2126 Argonne, IL 60439 630-252-0023 hfinkel...

  10. Gordon McPheeters | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Gordon McPheeters HPC Systems Administration Specialist - File Systems Argonne National Laboratory 9700 S. Cass Avenue Building 240 - Rm. 1122 Argonne, IL 60439 630-252-6430...

  11. Sunhwan Jo | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Sunhwan Jo Postdoctoral Appointee - HPC Sunhwan Jo Argonne National Laboratory 9700 S. Cass Avenue Building 240 - Wkstn. 1D20 Argonne, IL 60439 630-252-5030 sjo...

  12. Khairi Reda | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Khairi Reda Argonne Scholar Khairi Reda Argonne National Laboratory 9700 S. Cass Avenue Building 240 Rm. 5138 Argonne, IL 60439 630-252-3678 kreda...

  13. Hyeondeok Shin | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Hyeondeok Shin Postdoctoral Appointee Argonne National Laboratory 9700 S. Cass Avenue Building 240 - Wkstn. 2C7 Argonne, IL 60439 630-252-7993 hshin...

  14. Margaret Kaczmarski | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Margaret Kaczmarski User Experience Administrator Margaret Kaczmarski Argonne National Laboratory 9700 South Cass Avenue Building 240 - Wkstn. 2D25 Argonne IL, 60439 630-252-0958...

  15. Michael Zhang | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Zhang Software Developer Argonne National Laboratory 9700 S. Cass Avenue Building 240 - Wkstn. 3D29 Argonne, IL 60439 zhangm@anl.gov...

  16. Silvio Rizzi | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Silvio Rizzi Postdoctoral Appointee - Visualization & Analysis Silvio Rizzi Argonne National Laboratory 9700 South Cass Avenue Building 240 - Rm. 4140 Argonne, IL 60439...

  17. Ryan Milner | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Ryan Milner HPC Network Administrator Specialist Ryan Milner Argonne National Laboratory 9700 South Cass Avenue Building 240 - Rm. 2121 Argonne, IL 60439 630-252-6084 rmilner...

  18. Better Buildings Neighborhood Program Peer Exchange Call: Structuring...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    * Austin, TX * Chicago, IL * Los Angeles County * Maryland * Nashville, TN * New Hampshire * North Carolina * Phoenix, AZ 2272015 3 Energy Upgrade California In Los ...

  19. BetterBuildings Financing Peer Exchange Kick-off Call Call Slides...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Lucie County, FL * Chicago, IL * Maryland * New Hampshire * Bedford, NY * Cincinnati, OH * Toledo-Lucas Co. Port Authority, OH * Seattle, WA * Wisconsin 4282011 4 Discussion ...

  20. The Sloan Digital Sky Survey Quasar Lens Search. IV. Statistical...

    Office of Scientific and Technical Information (OSTI)

    Article Resource Relation: Journal Name: Submitted to Astron.J.; Journal Volume: 140; Journal Issue: 2 Research Org: Fermi National Accelerator Laboratory (FNAL), Batavia, IL...

  1. Darin Wills | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Darin Wills Assistant Division Director Darin Wills Argonne National Laboratory 9700 South Cass Avenue Building 240 - Rm. 3127 Argonne, IL 60439 630-252-0355 dwills

  2. David Martin | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    David Martin Industrial Outreach Lead David Martin Argonne National Laboratory 9700 South Cass Avenue Building 240 - Rm. 3126 Argonne, IL 60439 630-252-0929 dem

  3. Derek Jensen | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Derek Jensen HPC Systems Administration Associate Argonne National Laboratory 9700 S. Cass Avenue Bldg. 240 - Wkstn. 2C6 Argonne, IL 60439 630-252-5770 jensend

  4. Diane Rodi | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Diane Rodi ALD ESH/QA Coordinator Argonne National Laboratory 9700 S. Cass Avenue Building 240 - Rm. 4125 Argonne, IL 60439 630-252-1617 drodi

  5. Douglas Waldron | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Douglas Waldron Senior Data Architect Douglas Waldron Argonne National Laboratory 9700 South Cass Avenue Building 240 - Rm. 3120 Argonne, IL 60439 630-252-2884 dwaldron

  6. Ed Holohan | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Ed Holohan Principal HPC Network Administration Specialist Ed Holohan Argonne National Laboratory 9700 South Cass Avenue Building 240 - Rm. 2121 Argonne, IL 60439 630-252-6094 eholohan

  7. Edouard Brooks | Argonne Leadership Computing Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Edouard Brooks Research Aide Argonne National Laboratory 9700 S. Cass Avenue Bldg. 240 - Wkstn. 4G10 Argonne, IL 60439 ebrooks

  8. Microsoft PowerPoint - 3_FG2 scoping_Ameren

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Meredosia Plant Location - Meredosia, IL Operated by Ameren Energy Resources 4 existing units, 3-coal fired (2 suspended), 1-oil-fired Illinois and Western Coal Truck & barge ...

  9. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    IL (United States) Atlanta Regional Office, Atlanta, GA (United States) Atmospheric System Research Bartlesville Project Office, OK (United States) Battelle Memorial...

  10. TITLE AUTHORS SUBJECT SUBJECT RELATED DESCRIPTION PUBLISHER AVAILABILI...

    Office of Scientific and Technical Information (OSTI)

    National Accelerator Lab FNAL Batavia IL United States PARTICLE ACCELERATORS BEAM OPTICS CHANNELING ATTENUATION BEAM EXTRACTION BENDING CRYSTALS MESON BEAMS BEAMS PARTICLE...

  11. Carrigan, Jr., Richard A. [Fermi National Accelerator Lab. (FNAL...

    Office of Scientific and Technical Information (OSTI)

    Accelerator Lab. (FNAL), Batavia, IL (United States) 43 PARTICLE ACCELERATORS; BEAM OPTICS; CHANNELING; ATTENUATION; BEAM EXTRACTION; BENDING; CRYSTALS; MESON BEAMS; BEAMS;...

  12. Sr:s I

    Office of Legacy Management (LM)

    Sr:s I t . DOEEV-000543 AN L.OHSH P.83.107 rL.06 - 03 b lii; t-. pr .S Fi ,i i1 l';, ln ti V: iii li4 i.:l tf,i 'Jt ru' ,,: :.5 i i l t:' i:t s:l 3 E. il t; ,:; ; ...

  13. Alaska

    Energy.gov [DOE] (indexed site)

    a v ast, s parsely p opulated l and a rea w ith o ver 30,000 m iles o f o cean c oastline. ... T he state i s a m ajor o il a nd g as e xporter, w ith c ritical o il p roduction assets, ...

  14. MEMORANDUM TO: FILE DATE

    Office of Legacy Management (LM)

    ... OWWA IL.16 U'.@ltW, T. G51544 IL.16 ZEITLIN, F. TO DISTHICT EMMER DISTRICT EhWEER NMDEN, E. DRIMs,F. mm, F. ch%WA, T. ZlETLIN, F. ZEITLIN, F. FtETCIW,L. SWEET TFttwITlkoF ...

  15. EFFECTS OF GAMMA RADIATION ON ELECTROCHEMICAL PROPERTIES OF IONIC LIQUIDS

    SciTech Connect

    Visser, A; Nicholas Bridges, N; Thad Adams, T; John Mickalonis, J; Mark02 Williamson, M

    2009-04-21

    The electrochemical properties of ionic liquids (ILs) make them attractive for possible replacement of inorganic salts in high temperature molten salt electrochemical processing of nuclear fuel. To be a feasible replacement solvent, ILs need to be stable in moderate and high doses of radiation without adverse chemical and physical effects. Here, we exposed seven different ILs to a 1.2 MGy dose of gamma radiation to investigate their physical and chemical properties as they related to radiological stability. The azolium-based ILs experienced the greatest change in appearance, but these ILs were chemically more stable to gamma radiation than some of the other classes of ILs tested, due to the presence of aromatic electrons in the azolium ring. All the ILs exhibited a decrease in their conductivity and electrochemical window (at least 1.1 V), both of which could affect the utility of ILs in electrochemical processing. The concentration of the irradiation decomposition products was less than 3 mole %, with no impurities detectable using NMR techniques.

  16. Impressions on Chinas Popular Republic

    ScienceCinema

    None

    2016-07-12

    Le D.G. Jentschke présente le Prof.Yang, née en 1922 en Chine où il a aussi fait ses études; il parle de ses impressions en Chine (p.e. mariage etc....) avec présentation des dias

  17. EMSL-LV-539-12 EMSL-LV-0539-12 OFF-SITE ENVXRDNMENTAL MONITORING...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... y(n.-1)) il il ' 703 LCL

  18. Ionic liquids composed of phosphonium cations and organophosphate, carboxylate, and sulfonate as lubricant antiwear additives

    DOE PAGES [OSTI]

    Zhou, Yan; Dyck, Jeffrey; Graham, Todd; Luo, Huimin; Leonard, Donovan N.; Qu, Jun

    2014-10-20

    Oil-soluble phosphonium-based ionic liquids (ILs) have recently been reported as potential ashless lubricant additives. This study is to expand the IL chemistry envelope and to achieve fundamental correlations between the ion structures and ILs’ physiochemical and tribological properties. Here we present eight ILs containing two different phosphonium cations and seven different anions from three groups: organophosphate, carboxylate, and sulfonate. The oil solubility of ILs seems largely governed by the IL molecule size and structure complexity. When used as oil additives, the ranking of effectiveness in wear protection for the anions are: organophosphate > carboxylate > sulfonate. All selected ILs outperformedmore » a commercial ashless anti-wear additive. Surface characterization from the top and the cross-section revealed the nanostructures and compositions of the tribo-films formed by the ILs. Some fundamental insights were achieved: branched and long alkyls improve the IL’s oil solubility, anions of a phosphonium-phosphate IL contribute most phosphorus in the tribofilm, and carboxylate anions, though free of P, S, N, or halogen, can promote the formation of an anti-wear tribofilm.« less

  19. Ionic liquids composed of phosphonium cations and organophosphate, carboxylate, and sulfonate as lubricant antiwear additives

    SciTech Connect

    Zhou, Yan; Dyck, Jeffrey; Graham, Todd; Luo, Huimin; Leonard, Donovan N.; Qu, Jun

    2014-10-20

    Oil-soluble phosphonium-based ionic liquids (ILs) have recently been reported as potential ashless lubricant additives. This study is to expand the IL chemistry envelope and to achieve fundamental correlations between the ion structures and ILs’ physiochemical and tribological properties. Here we present eight ILs containing two different phosphonium cations and seven different anions from three groups: organophosphate, carboxylate, and sulfonate. The oil solubility of ILs seems largely governed by the IL molecule size and structure complexity. When used as oil additives, the ranking of effectiveness in wear protection for the anions are: organophosphate > carboxylate > sulfonate. All selected ILs outperformed a commercial ashless anti-wear additive. Surface characterization from the top and the cross-section revealed the nanostructures and compositions of the tribo-films formed by the ILs. Some fundamental insights were achieved: branched and long alkyls improve the IL’s oil solubility, anions of a phosphonium-phosphate IL contribute most phosphorus in the tribofilm, and carboxylate anions, though free of P, S, N, or halogen, can promote the formation of an anti-wear tribofilm.

  20. TiO2 nanotube arrays grown in ionic liquids: high-efficiency in photocatalysis and pore-widening

    SciTech Connect

    Li, Huaqing; Qu, Jun; Cui, Qingzhou; Xu, Hanbing; Luo, Huimin; Chi, Miaofang; Meisner, Roberta Ann; Wang, Wei; Dai, Sheng

    2011-01-01

    Debris-free, long, well-separated TiO2 nanotube arrays were obtained using an ionic liquid (IL) as electrolyte. The high conductivity of IL resulted in fast pore widening and few contaminants from electrolyte decomposition leading to high photocatalytic efficiency in water splitting.

  1. Polymorphism of inflammatory genes and arsenic methylation capacity are associated with urothelial carcinoma

    SciTech Connect

    Wu, Chia-Chang; Huang, Yung-Kai; Chung, Chi-Jung; Huang, Chao-Yuan; Pu, Yeong-Shiau; Shiue, Horng-Sheng; Lai, Li-An; Lin, Ying-Chin; Su, Chien-Tien; Hsueh, Yu-Mei

    2013-10-01

    Chronic exposure to arsenic can generate reactive oxidative species, which can induce certain proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8). TNF-α, IL-6 and IL-8 have been shown to be involved in the development and progression of various cancers, including bladder cancer. This study aimed to investigate the joint effect of the polymorphism of TNF-α − 308 G/A, IL-6 − 174 G/C, IL-8 − 251 T/A and urinary arsenic profiles on urothelial carcinoma (UC) risk. This study evaluated 300 pathologically-confirmed cases of UC and 594 cancer-free controls. Urinary arsenic species were detected using high-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. The polymorphism of TNF-α − 308 G/A, IL-6 − 174 G/C and IL-8 − 251 T/A was determined using polymerase chain reaction-restriction fragment length polymorphism. The joint effects on UC risk were estimated by odds ratios and 95% confidence intervals using unconditional logistic regression. We found that the TNF-α − 308 A/A and IL-8 − 251 T/T polymorphisms were significantly associated with UC. Moreover, significant dose–response joint effect of TNF-α − 308 A/A or IL-8 − 251 T/T genotypes and arsenic methylation indices were seen to affect UC risk. The present results also showed a significant increase in UC risk in subjects with the IL-8 − 251 T/T genotype for each SD increase in urinary total arsenic and MMA%. In contrast, a significant decrease in UC risk was found in subjects who carried the IL-8 − 251 T/T genotype for each SD increase in DMA%. - Highlights: • Joint effect of the TNF-α -308 A/A genotype and urinary total arsenic affected UC. • Joint effect of the IL-8 -251 T/T genotype and urinary total arsenic affected UC. • Urinary total arsenic level, TNF-α -308 A/A and IL-8 -251 T/T genotype affected UC.

  2. Phase-Changing Ionic Liquids: CO2 Capture with Ionic Liquids Involving Phase Change

    SciTech Connect

    2010-07-01

    IMPACCT Project: Notre Dame is developing a new CO2 capture process that uses special ionic liquids (ILs) to remove CO2 from the gas exhaust of coal-fired power plants. ILs are salts that are normally liquid at room temperature, but Notre Dame has discovered a new class of ILs that are solid at room temperature and change to liquid when they bind to CO2. Upon heating, the CO2 is released for storage, and the ILs re-solidify and donate some of the heat generated in the process to facilitate further CO2 release. These new ILs can reduce the energy required to capture CO2 from the exhaust stream of a coal-fired power plant when compared to state-ofthe- art technology.

  3. Club of Rome

    ScienceCinema

    None

    2016-07-12

    Le Club de Rome s'est fait connaître du grand public par la publication du premier ouvrage "Halte à la croissance" qui a fait l'object d'un débat, il y a 2 ans. Le Prof. Tinbergen a commencé par s'adonner à la physique, il est docteur en physique et très tôt il s'est tourné vers les problèmes sociaux économiques. Il est expert auprès des nombreux gouvernements et organisations internationales et il a vu ses travaux couronnés par le prix Nobel en 1969.

  4. Tribological characteristics of aluminum alloys against steel lubricated by ammonium and imidazolium ionic liquids

    SciTech Connect

    Qu, Jun; Blau, Peter Julian; Dai, Sheng; Luo, Huimin; Meyer III, Harry M; Truhan, John J.

    2009-01-01

    Sliding friction and wear characteristics of aluminum alloys against AISI 52100 steel lubricated by ionic liquids (ILs) were investigated at both room and elevated temperatures. The tested aluminum alloys include a commercially pure aluminum Al 1100, a wrought alloy Al 6061-T6511, and a cast alloy Al 319-T6. The lubricating performance of two ILs with the same anion, one ammonium-based [C8H17]3NH.Tf2N and one imidazolium-based C10mim.Tf2N, were compared each other and benchmarked against that of a conventional fully-formulated engine oil. Significant friction (up to 35%) and wear (up to 55%) reductions were achieved by the ammonium IL when lubricating the three aluminum alloys compared to the engine oil. The imidazolium IL performed better than the oil but not as well as the ammonium IL for Al 1100 and 319 alloys. However, accelerated wear was unexpectedly observed for Al 6061 alloy when lubricated by C10mim.Tf2N. Surface chemical analyses implied complex tribochemical reactions between the aluminum surfaces and ILs during the wear testing, which has been demonstrated either beneficial by forming a protective boundary film or detrimental by causing severe tribo-corrosion. The effects of the IL cation structure, aluminum alloy composition, and tribo-testing condition on the friction and wear results have been discussed.

  5. Hydrogen-bonding interactions and protic equilibria in room-temperature ionic liquids containing crown ethers.

    SciTech Connect

    Marin, T.; Shkrob, I.; Dietz, M.

    2011-04-14

    Nuclear magnetic resonance (NMR) spectroscopy has been used to study hydrogen-bonding interactions between water, associated and dissociated acids (i.e., nitric and methanesulfonic acids), and the constituent ions of several water-immiscible room-temperature ionic liquids (ILs). In chloroform solutions also containing a crown ether (CE), water molecules strongly associate with the IL ions, and there is rapid proton exchange between these bound water molecules and hydronium associated with the CE. In neat ILs, the acids form clusters differing in their degree of association and ionization, and their interactions with the CEs are weak. The CE can either promote proton exchange between different clusters in IL solution when their association is weak or inhibit such exchange when the association is strong. Even strongly hydrophobic ILs are shown to readily extract nitric acid from aqueous solution, typically via the formation of a 1:1:1 {l_brace}H{sub 3}O{sup +} {center_dot} CE{r_brace}NO{sub 3}{sup -} complex. In contrast, the extraction of methanesulfonic acid is less extensive and proceeds mainly by IL cation-hydronium ion exchange. The relationship of these protic equilibria to the practical application of hydrophobic ILs (e.g., in spent nuclear fuel reprocessing) is discussed.

  6. Effect of Molecular Weight on the Ion Transport Mechanism in Polymerized Ionic Liquids

    DOE PAGES [OSTI]

    Fan, Fei; Wang, Weiyu; Holt, Adam P.; Feng, Hongbo; Uhrig, David; Lu, Xinyi; Hong, Tao; Wang, Yangyang; Kang, Nam-Goo; Mays, Jimmy; et al

    2016-06-07

    The unique properties of ionic liquids (ILs) have made them promising candidates for electrochemical applications. Polymerization of the corresponding ILs results in a new class of materials called polymerized ionic liquids (PolyILs). Though PolyILs offer the possibility to combine the high conductivity of ILs and the high mechanical strength of polymers, their conductivities are typically much lower than that of the corresponding small molecule ILs. In this study, seven PolyILs were synthesized having degrees of polymerization ranging from 1 to 333, corresponding to molecular weights (MW) from 482 to 160 400 g/mol. Depolarized dynamic light scattering, broadband dielectric spectroscopy, rheology,more » and differential scanning calorimetry were employed to systematically study the influence of MW on the mechanism of ionic transport and segmental dynamics in these materials. Finally, the modified Walden plot analysis reveals that the ion conductivity transforms from being closely coupled with structural relaxation to being strongly decoupled from it as MW increases.« less

  7. Oil-Miscible and Non-Corrosive Phosphonium Ionic Liquids as Candidate Lubricant Additives

    SciTech Connect

    Yu, Bo; Bansal, Dinesh G; Qu, Jun; Sun, Xiaoqi; Luo, Huimin; Dai, Sheng; Blau, Peter Julian; Bunting, Bruce G; Mordukhovich, Gregory; Smolenski, Donald

    2012-01-01

    Ionic liquids (ILs) have been receiving considerable attention from the lubricants industry as potential friction and wear-reducing additives, but their solubility in oils is an issue. Unlike most ionic liquids that are insoluble in non-polar hydrocarbon oils, this study reports phosphonium-based ILs (PP-ILs) that are fully miscible with both mineral oil-based and synthetic lubricants. Both the cation and anion in quaternary structures, long alkyl chains, and capability of pairing the cation and the anion via a H-O bond are hypothesized to improve the compatibility between ions and neutral oil molecules. The measured viscosities of the oil-IL blends agree well with the Refutas equation that is for solutions containing multiple components. High thermal stability and non-corrosiveness were observed for the PP-ILs. Effective friction reduction and anti-wear functionality have been demonstrated in tribological tests when adding 5 wt% of a PP-IL into a base oil, suggesting potential applications for using the oil-miscible PP-ILs as lubricant additives.

  8. Phosphonium-Organophosphate Ionic Liquids as Lubricant Additives: Effects of Cation Structure on Physicochemical and Tribological Characteristics

    DOE PAGES [OSTI]

    Barnhill, William C.; Qu, Jun; Luo, Huimin; Meyer III, Harry M.; Ma, Cheng; Chi, Miaofang; Papke, Brian L.

    2014-11-17

    In our previous work we suggest great potential for a phosphonium-organophosphate ionic liquid (IL) as an antiwear lubricant additive. In this study, a set of five ILs were carefully designed and synthesized, with identical organophosphate anions but dissimilar phosphonium cations, to allow systematic investigation of the effects of cation alkyl chain length and symmetry on physicochemical and tribological properties. Symmetric cations with shorter alkyl chains seem to increase the density and thermal stability due to closer packing. On the other hand, either higher cation symmetry or longer alkyl moieties induce a higher viscosity, though the viscosity index is dependent moremore » on molecular mass than on symmetry. While a larger cation size generally increases an IL’s solubility in nonpolar hydrocarbon oils, six-carbon seems to be the critical minimum alkyl chain length for high oil miscibility. Both the two ILs, that are mutually oil miscible, have demonstrated promising lubricating performance at 1.04% treat rate, though the symmetric-cation IL moderately outperformed the asymmetric-cation IL. Moreover, characterizations on the tribofilm formed by the best-performing symmetric-cation IL revealed the film thickness, nanostructure, and chemical composition. Our results provide fundamental insights for future molecular design in developing oil-soluble ILs as lubricant additives.« less

  9. Phosphonium-Organophosphate Ionic Liquids as Lubricant Additives: Effects of Cation Structure on Physicochemical and Tribological Characteristics

    SciTech Connect

    Barnhill, William C.; Qu, Jun; Luo, Huimin; Meyer III, Harry M.; Ma, Cheng; Chi, Miaofang; Papke, Brian L.

    2014-11-17

    In our previous work we suggest great potential for a phosphonium-organophosphate ionic liquid (IL) as an antiwear lubricant additive. In this study, a set of five ILs were carefully designed and synthesized, with identical organophosphate anions but dissimilar phosphonium cations, to allow systematic investigation of the effects of cation alkyl chain length and symmetry on physicochemical and tribological properties. Symmetric cations with shorter alkyl chains seem to increase the density and thermal stability due to closer packing. On the other hand, either higher cation symmetry or longer alkyl moieties induce a higher viscosity, though the viscosity index is dependent more on molecular mass than on symmetry. While a larger cation size generally increases an IL’s solubility in nonpolar hydrocarbon oils, six-carbon seems to be the critical minimum alkyl chain length for high oil miscibility. Both the two ILs, that are mutually oil miscible, have demonstrated promising lubricating performance at 1.04% treat rate, though the symmetric-cation IL moderately outperformed the asymmetric-cation IL. Moreover, characterizations on the tribofilm formed by the best-performing symmetric-cation IL revealed the film thickness, nanostructure, and chemical composition. Our results provide fundamental insights for future molecular design in developing oil-soluble ILs as lubricant additives.

  10. Receptor expression is essential for proliferation induced by dimerized Jak kinases

    SciTech Connect

    Fujii, Hodaka

    2008-06-13

    Two members of Jak kinases, Jak1 and Jak3, are associated with the cytoplasmic domains of the interleukin-2 (IL-2) receptor (IL-2R) {beta} chain (IL-2R{beta}) and the common cytokine receptor {gamma} chain ({gamma}c), respectively, and accumulating evidence indicates their functional importance in IL-2 signaling. Here, I showed that coumermycin-induced chemical heterodimerization of Jak1 and Jak3 but not homodimerization of Jak1 or Jak3 induces cell proliferation of an IL-2R-reconstituted cell line. In this regard, expression of IL-2R{beta} was essential for cell proliferation by chemical heterodimerization of Jak1 and Jak3, indicating that dimerized Jak1 and Jak3 induce heterodimerization of IL-2R{beta} and {gamma}c, which may activate receptor-bound signaling molecules. Previous reports using chemical dimerization suggest that dimerization of Jak kinases is sufficient to induce cell proliferation. The present study indicates that re-evaluation of this conclusion is necessary and that interpretation of functional analysis of signaling molecules using chemical dimerizers needs more careful assessment.

  11. Detection of three nonsense mutations and one missense mutation in the interleukin-2 receptor [gamma] chain gene in SCIDX1 that differently affect the mRNA processing

    SciTech Connect

    Markiewicz, S.; Fischer, A.; Saint Basile, G. de ); Subtil, A.; Dautry-Varsat, A. )

    1994-05-01

    The interleukin-2 receptor [gamma] (IL-2R[gamma]) chain gene encodes a 64-kDa protein that not only composes the high-affinity form of the IL-2 binding receptor in association with the 2R [alpha] and [beta] chains, but also participates in at least the IL-4 and IL-7 receptor complexes. Mutations in this gene have recently been shown to cause X-linked severe combined immunodeficiency (SCIDX1). This disease of the immune system results from an early block of T lymphocyte and natural killer (NK) cell differentiation, which leads to a severe cellular and humoral immune defect that is lethal unless treated by bone marrow transplantation. Analysis of the IL-2R[gamma] gene in SCIDX1 patients has revealed the presence of heterogeneous mutations principally located in the extracellular domain of the molecule. We report here three intraexonic mutations and one deletion in the IL-2R[gamma] gene in four SCIDX1 patients. These mutations appear to differentially affect RNA processing, either by decreasing IL-2R[gamma] mRNA level or by the skipping of a constitutive exon. 16 refs., 1 fig.

  12. Kinetics of expression of interleukin 2 receptors on class I and class II restricted murine T cell clones

    SciTech Connect

    Churilla, A.; Braciale, V.; Braciale, T.

    1986-03-05

    The kinetics of interleukin 2 receptor (IL-2R) expression has been examined on various class I and class II restricted, influenza specific murine T cell clones. Expression and relative levels of IL-2R were examined by Fluorescence Activated Cell Sorter analysis utilizing 3 anti-murine IL-2R monoclonal antibodies. Receptor expression was analyzed by scatchard analysis using radiolabeled recombinant human interleukin 2 to access the number of high and low affinity IL-2R per cell as well as the affinity of binding. The clones tested bound all 3 monoclonal antibodies and were inhibited in an IL-2 dependent proliferation assay by the addition of the antibodies to the culture. There was, however, differing degrees of inhibition ranging up to 99%, depending on the clone and the antibody used. IL-2R expression was detectable as early as 4-6 hours after antigenic stimulation of quiescent cells. After maximal levels of receptors were expressed, which was about 24 hours after stimulation, expression of IL-2R decreased with time on all clones examined (both class I and class II restricted). Differing rates of receptor loss is seen however, with some class II restricted clones retaining relatively high levels of receptors.

  13. Deprotonation and oligomerization in photo-, radiolytically and electrochemically induced redox reactions in hydrophobic alkylalkylimidazolium ionic liquids.

    SciTech Connect

    Shkrob, I . A.; Chemical Sciences and Engineering Division

    2010-01-14

    Radical chemistry initiated by one-electron reduction of 1-methyl-3-alkylimidazolium cations in the corresponding ionic liquids (ILs) is examined. The reaction scheme is examined in light of the recent experimental data on photo-, radiation-, and electrochemically induced degradation of the practically important hydrophobic alkylimidazolium ILs. It is suggested that the primary species leading to the formation of the oligomers and acidification of the IL is a {sigma}{sigma}* dimer radical cation that loses a proton, yielding a neutral radical whose subsequent reactions produce C(2)-C(2) linked oligomers, both neutral and charged. The neutral oligomers (up to the tetramer) account for the features observed in the NMR spectra of cathodic liquid generated in electrolytic breakdown of the IL solvent. In photolysis and radiolysis, these neutral species and/or their radical precursors are oxidized by radical (ions) derived from the counteranions, and only charged dimers are observed. The dication dimers account for the features observed in the mass spectra of irradiated ILs. The products of these ion radical and radical reactions closely resemble those generated via carbene chemistry, without the formation of the carbene via the deprotonation of the parent cation. As the loss of 2-protons increases the proticity of the irradiated IL, it interferes with the extraction of metal ions by ionophore solutes, while the formation of the oligomers modifies solvent properties. Thus, the peculiarities of radical chemistry in the alkylimidazolium ILs have significant import for their practical applications.

  14. Identification of a haloalkaliphilic and thermostable cellulase with improved ionic liquid tolerance

    SciTech Connect

    Zhang, Tao; Datta, Supratim; Eichler, Jerry; Ivanova, Natalia; Axen, Seth D.; Kerfeld, Cheryl A.; Chen, Feng; Kyrpides, Nikos; Hugenholtz, Philip; Cheng, Jan-Fang; Sale, Kenneth L.; Simmons, Blake; Rubin, Eddy

    2011-02-17

    Some ionic liquids (ILs) have been shown to be very effective solvents for biomass pretreatment. It is known that some ILs can have a strong inhibitory effect on fungal cellulases, making the digestion of cellulose inefficient in the presence of ILs. The identification of IL-tolerant enzymes that could be produced as a cellulase cocktail would reduce the costs and water use requirements of the IL pretreatment process. Due to their adaptation to high salinity environments, halophilic enzymes are hypothesized to be good candidates for screening and identifying IL-resistant cellulases. Using a genome-based approach, we have identified and characterized a halophilic cellulase (Hu-CBH1) from the halophilic archaeon, Halorhabdus utahensis. Hu-CBH1 is present in a gene cluster containing multiple putative cellulolytic enzymes. Sequence and theoretical structure analysis indicate that Hu-CBH1 is highly enriched with negatively charged acidic amino acids on the surface, which may form a solvation shell that may stabilize the enzyme, through interaction with salt ions and/or water molecules. Hu-CBH1 is a heat tolerant haloalkaliphilic cellulase and is active in salt concentrations up to 5 M NaCl. In high salt buffer, Hu-CBH1 can tolerate alkali (pH 11.5) conditions and, more importantly, is tolerant to high levels (20percent w/w) of ILs, including 1-allyl-3-methylimidazolium chloride ([Amim]Cl). Interestingly, the tolerances to heat, alkali and ILs are found to be salt-dependent, suggesting that the enzyme is stabilized by the presence of salt. Our results indicate that halophilic enzymes are good candidates for the screening of IL-tolerant cellulolytic enzymes.

  15. In vivo uptake and acute immune response to orally administered chitosan and PEG coated PLGA nanoparticles

    SciTech Connect

    Semete, B.; Booysen, L.I.J.; Kalombo, L.; Venter, J.D.; Katata, L.; Ramalapa, B.; Verschoor, J.A.; Swai, H.

    2010-12-01

    Nanoparticulate drug delivery systems offer great promise in addressing challenges of drug toxicity, poor bioavailability and non-specificity for a number of drugs. Much progress has been reported for nano drug delivery systems for intravenous administration, however very little is known about the effects of orally administered nanoparticles. Furthermore, the development of nanoparticulate systems necessitates a thorough understanding of the biological response post exposure. This study aimed to elucidate the in vivo uptake of chitosan and polyethylene glycol (PEG) coated Poly, DL, lactic-co-glycolic Acid (PLGA) nanoparticles and the immunological response within 24 h of oral and peritoneal administration. These PLGA nanoparticles were administered orally and peritoneally to female Balb/C mice, they were taken up by macrophages of the peritoneum. When these particles were fluorescently labelled, intracellular localisation was observed. The expression of pro-inflammatory cytokines IL-2, IL-6, IL-12p70 and TNF-{alpha} in plasma and peritoneal lavage was found to remain at low concentration in PLGA nanoparticles treated mice as well as ZnO nanoparticles during the 24 hour period. However, these were significantly increased in lipopolysaccharide (LPS) treated mice. Of these pro-inflammatory cytokines, IL-6 and IL-12p70 were produced at the highest concentration in the positive control group. The anti-inflammatory cytokines IL-10 and chemokines INF-{gamma}, IL-4, IL-5 remained at normal levels in PLGA treated mice. IL-10 and INF-{gamma} were significantly increased in LPS treated mice. MCP-1 was found to be significantly produced in all groups in the first hours, except the saline treated mice. These results provide the first report to detail the induction of cytokine production by PLGA nanoparticles engineered for oral applications.

  16. Ionic Liquids as Novel Lubricants and /or Lubricant Additives

    SciTech Connect

    Qu, J.; Viola, M. B.

    2013-10-31

    This ORNL-GM CRADA developed ionic liquids (ILs) as novel lubricants or oil additives for engine lubrication. A new group of oil-miscible ILs have been designed and synthesized with high thermal stability, non-corrosiveness, excellent wettability, and most importantly effective anti-scuffing/anti-wear and friction reduction characteristics. Mechanistic analysis attributes the superior lubricating performance of IL additives to their physical and chemical interactions with metallic surfaces. Working with a leading lubricant formulation company, the team has successfully developed a prototype low-viscosity engine oil using a phosphonium-phosphate IL as an anti-wear additive. Tribological bench tests of the IL-additized formulated oil showed 20-33% lower friction in mixed and elastohydrodynamic lubrication and 38-92% lower wear in boundary lubrication when compared with commercial Mobil 1 and Mobil Clean 5W-30 engine oils. High-temperature, high load (HTHL) full-size engine tests confirmed the excellent anti-wear performance for the IL-additized engine oil. Sequence VID engine dynamometer tests demonstrated an improved fuel economy by >2% for this IL-additized engine oil benchmarked against the Mobil 1 5W-30 oil. In addition, accelerated catalyst aging tests suggest that the IL additive may potentially have less adverse impact on three-way catalysts compared to the conventional ZDDP. Follow-on research is needed for further development and optimization of IL chemistry and oil formulation to fully meet ILSAC GF-5 specifications and further enhance the automotive engine efficiency and durability.

  17. Transforming growth factor β-activated kinase 1 negatively regulates interleukin-1α-induced stromal-derived factor-1 expression in vascular smooth muscle cells

    SciTech Connect

    Yang, Bin; Li, Wei; Zheng, Qichang; Qin, Tao; Wang, Kun; Li, Jinjin; Guo, Bing; Yu, Qihong; Wu, Yuzhe; Gao, Yang; Cheng, Xiang; Hu, Shaobo; Kumar, Stanley Naveen; Liu, Sanguang; Song, Zifang

    2015-07-17

    Stromal-derived Factor-1 (SDF-1) derived from vascular smooth muscle cells (VSMCs) contributes to vascular repair and remodeling in various vascular diseases. In this study, the mechanism underlying regulation of SDF-1 expression by interleukin-1α (IL-1α) was investigated in primary rat VSMCs. We found IL-1α promotes SDF-1 expression by up-regulating CCAAT-enhancer-binding protein β (C/EBPβ) in an IκB kinase β (IKKβ) signaling-dependent manner. Moreover, IL-1α-induced expression of C/EBPβ and SDF-1 was significantly potentiated by knockdown of transforming growth factor β-activated kinase 1 (TAK1), an upstream activator of IKKβ signaling. In addition, we also demonstrated that TAK1/p38 mitogen-activated protein kinase (p38 MAPK) signaling exerted negative effect on IL-1α-induced expression of C/EBPβ and SDF-1 through counteracting ROS-dependent up-regulation of nuclear factor erythroid 2-related factor 2 (NRF2). In conclusion, TAK1 acts as an important regulator of IL-1α-induced SDF-1 expression in VSMCs, and modulating activity of TAK1 may serve as a potential strategy for modulating vascular repair and remodeling. - Highlights: • IL-1α induces IKKβ signaling-dependent SDF-1 expression by up-regulating C/EBPβ. • Activation of TAK1 by IL-1α negatively regulates C/EBPβ-dependent SDF-1 expression. • IL-1α-induced TAK1/p38 MAPK signaling counteracts ROS-dependent SDF-1 expression. • TAK1 counteracts IL-1α-induced SDF-1 expression by attenuating NRF2 up-regulation.

  18. Synergistic Effects of Mixing Sulfone and Ionic Liquid as Safe Electrolytes

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    for Lithium Sulfur Batteries - Joint Center for Energy Storage Research November 24, 2014, Research Highlights Synergistic Effects of Mixing Sulfone and Ionic Liquid as Safe Electrolytes for Lithium Sulfur Batteries a) Structures of the ionic liquid (IL) and sulfone b) ionic conductivity (σ) vs IL ratio c) CV of C-S cathode in IL/sulfone mixture d) cycling performance Scientific Achievement A strategy of mixing both an ionic liquid and sulfone is applied in Li-S batteries to give

  19. computational-structural-mechanics-training

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Table of Contents Date Location Training Course: HyperMesh and HyperView April 12-14, 2011 Argonne TRACC Argonne, IL Introductory Course: Developing Compute-efficient, Quality Models with LS-PrePost® 3 on the TRACC Cluster October 21-22, 2010 Argonne TRACC West Chicago, IL Modeling and Simulation with LS-DYNA®: Insights into Modeling with a Goal of Providing Credible Predictive Simulations February 11-12, 2010 Argonne TRACC West Chicago, IL Introductory Course: Using LS-OPT® on the TRACC

  20. Southern Great Plains

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Southern Great Plains Climate C hange a nd t he U .S. E nergy S ector: Regional v ulnerabilities a nd r esilience s olutions Summary i n B rief The S outhern G reat P lains r egion, c omprising K ansas, O klahoma, and T exas, c ontains o il a nd g as i nfrastructure c ritical t o t he nation's e nergy s upply, i ncluding n umerous o ffshore p latforms, onshore o il a nd g as w ells, o il r efineries, n atural g as p rocessing plants, p ipelines, a nd s hipping t erminals. M any o f t hese a