National Library of Energy BETA

Sample records for drug delivery systems

  1. Microfabricated injectable drug delivery system

    DOE Patents [OSTI]

    Krulevitch, Peter A.; Wang, Amy W.

    2002-01-01

    A microfabricated, fully integrated drug delivery system capable of secreting controlled dosages of multiple drugs over long periods of time (up to a year). The device includes a long and narrow shaped implant with a sharp leading edge for implantation under the skin of a human in a manner analogous to a sliver. The implant includes: 1) one or more micromachined, integrated, zero power, high and constant pressure generating osmotic engine; 2) low power addressable one-shot shape memory polymer (SMP) valves for switching on the osmotic engine, and for opening drug outlet ports; 3) microfabricated polymer pistons for isolating the pressure source from drug-filled microchannels; 4) multiple drug/multiple dosage capacity, and 5) anisotropically-etched, atomically-sharp silicon leading edge for penetrating the skin during implantation. The device includes an externally mounted controller for controlling on-board electronics which activates the SMP microvalves, etc. of the implant.

  2. Protein-Based Nanomedicine Platforms for Drug Delivery

    SciTech Connect (OSTI)

    Ma Ham, Aihui; Tang, Zhiwen; Wu, Hong; Wang, Jun; Lin, Yuehe

    2009-08-03

    Drug delivery systems have been developed for many years, however some limitations still hurdle the pace of going to clinical phase, for example, poor biodistribution, drug molecule cytotoxicity, tissue damage, quick clearance from the circulation system, solubility and stability of drug molecules. To overcome the limitations of drug delivery, biomaterials have to be developed and applied to drug delivery to protect the drug molecules and to enhance the drugs efficacy. Protein-based nanomedicine platforms for drug delivery are platforms comprised of naturally self-assembled protein subunits of the same protein or a combination of proteins making up a complete system. They are ideal for drug delivery platforms due to their biocompatibility and biodegradability coupled with low toxicity. A variety of proteins have been used and characterized for drug delivery systems including the ferritin/apoferritin protein cage, plant derived viral capsids, the small Heat shock protein (sHsp) cage, albumin, soy and whey protein, collagen, and gelatin. There are many different types and shapes that have been prepared to deliver drug molecules using protein-based platforms including the various protein cages, microspheres, nanoparticles, hydrogels, films, minirods and minipellets. There are over 30 therapeutic compounds that have been investigated with protein-based drug delivery platforms for the potential treatment of various cancers, infectious diseases, chronic diseases, autoimmune diseases. In protein-based drug delivery platforms, protein cage is the most newly developed biomaterials for drug delivery and therapeutic applications. Their uniform sizes, multifunctions, and biodegradability push them to the frontier for drug delivery. In this review, the recent strategic development of drug delivery has been discussed with a special emphasis upon the polymer based, especially protein-based nanomedicine platforms for drug delivery. The advantages and disadvantages are also

  3. Optically generated ultrasound for enhanced drug delivery

    DOE Patents [OSTI]

    Visuri, Steven R.; Campbell, Heather L.; Da Silva, Luiz

    2002-01-01

    High frequency acoustic waves, analogous to ultrasound, can enhance the delivery of therapeutic compounds into cells. The compounds delivered may be chemotherapeutic drugs, antibiotics, photodynamic drugs or gene therapies. The therapeutic compounds are administered systemically, or preferably locally to the targeted site. Local delivery can be accomplished through a needle, cannula, or through a variety of vascular catheters, depending on the location of routes of access. To enhance the systemic or local delivery of the therapeutic compounds, high frequency acoustic waves are generated locally near the target site, and preferably near the site of compound administration. The acoustic waves are produced via laser radiation interaction with an absorbing media and can be produced via thermoelastic expansion, thermodynamic vaporization, material ablation, or plasma formation. Acoustic waves have the effect of temporarily permeabilizing the membranes of local cells, increasing the diffusion of the therapeutic compound into the cells, allowing for decreased total body dosages, decreased side effects, and enabling new therapies.

  4. Secondary fuel delivery system

    DOE Patents [OSTI]

    Parker, David M.; Cai, Weidong; Garan, Daniel W.; Harris, Arthur J.

    2010-02-23

    A secondary fuel delivery system for delivering a secondary stream of fuel and/or diluent to a secondary combustion zone located in the transition piece of a combustion engine, downstream of the engine primary combustion region is disclosed. The system includes a manifold formed integral to, and surrounding a portion of, the transition piece, a manifold inlet port, and a collection of injection nozzles. A flowsleeve augments fuel/diluent flow velocity and improves the system cooling effectiveness. Passive cooling elements, including effusion cooling holes located within the transition boundary and thermal-stress-dissipating gaps that resist thermal stress accumulation, provide supplemental heat dissipation in key areas. The system delivers a secondary fuel/diluent mixture to a secondary combustion zone located along the length of the transition piece, while reducing the impact of elevated vibration levels found within the transition piece and avoiding the heat dissipation difficulties often associated with traditional vibration reduction methods.

  5. Soft-Template-Synthesized Mesoporous Carbon for Oral Drug Delivery

    SciTech Connect (OSTI)

    Saha, Dipendu; Warren, Kaitlyn E; Naskar, Amit K

    2014-01-01

    Template-synthesized mesoporous carbons were successfully used in in vitro investigations of controlled delivery of three model drugs, captopril, furosemide, and ranitidine hydrochloride. Captopril and furosemide exhibited desorption kinetics over 30 40 h, and ranitidine HCl had a complete release time of 5 10 h. As evident from the slow release kinetics, we contend that our mesoporous carbon is an improved drug-delivery medium compared to state-of-the-art porous silica-based substrates. The mesoporous carbons, synthesized from phloroglucinol and lignin, a synthetic and a sustainable precursor, respectively, exhibit BET surface area of 200 400 m2 g-1 and pore volume of 0.2 0.6 cm3 g-1. The phloroglucinol-based carbon has narrower pore widths and higher pore volume than the lignin-derived counterpart and maintains a longer release time. Numerical modeling of the release kinetics data reveals that the diffusivities of all the drugs from lignin-based carbon media are of equivalent magnitude (10-22 to 10-24 m2 s-1). However, a tailored reduction of pore width in the sorbent reduces the diffusivity of smaller drug molecules (captopril) by an order of magnitude. Thus, engineered pore morphology in our synthesized carbon sorbent, along with its potential to tailor the chemistry of its interaction with sorbet, can be exploited for optimal delivery system of a preferred drug within its therapeutic level and below the level of toxicity.

  6. Alendronate functionalized mesoporous hydroxyapatite nanoparticles for drug delivery

    SciTech Connect (OSTI)

    Li, Dongdong; Zhu, Yuntao; Liang, Zhiqiang

    2013-06-01

    Highlights: ? The synthesized mesoporous hydroxyapatite has nanostructure and bioactivity. ? The materials have high surface area and amino group. ? The materials show higher drug loading and slower release rate than pure HAP. - Abstract: Mesoporous nanosized hydroxyapatite (HAP) functionalized by alendronate (ALN) was synthesized using cationic surfactant CTAB as template. The structural, morphological and textural properties were fully characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR) and N{sub 2} adsorption/desorption. Then the obtained materials were performed as drug delivery carriers using ibuprofen (IBU) as a model drug to investigate their drug storage/release properties in simulated body fluid (SBF). The materials showed relatively slower release rate compared with HAP due to the ionic interaction between -NH{sub 3}{sup +} on the matrix and -COO{sup ?}belongs to IBU. The system provides a new concept for improving the drug loading or slowing down the release rate.

  7. Radiation delivery system and method

    DOE Patents [OSTI]

    Sorensen, Scott A.; Robison, Thomas W.; Taylor, Craig M. V.

    2002-01-01

    A radiation delivery system and method are described. The system includes a treatment configuration such as a stent, balloon catheter, wire, ribbon, or the like, a portion of which is covered with a gold layer. Chemisorbed to the gold layer is a radiation-emitting self-assembled monolayer or a radiation-emitting polymer. The radiation delivery system is compatible with medical catheter-based technologies to provide a therapeutic dose of radiation to a lesion following an angioplasty procedure.

  8. Fluid delivery control system

    DOE Patents [OSTI]

    Hoff, Brian D.; Johnson, Kris William; Algrain, Marcelo C.; Akasam, Sivaprasad

    2006-06-06

    A method of controlling the delivery of fluid to an engine includes receiving a fuel flow rate signal. An electric pump is arranged to deliver fluid to the engine. The speed of the electric pump is controlled based on the fuel flow rate signal.

  9. Energy Delivery Systems Cybersecurity | Department of Energy

    Energy.gov (indexed) [DOE]

    About the Cybersecurity for Energy Delivery Systems Program A key mission of the Department of Energy's (DOE) Office of Electricity Delivery and Energy Reliability (OE) is to ...

  10. Delivery of aerosolized drugs encapsulated in liposomes

    SciTech Connect (OSTI)

    Cheng, Yung-Sung; Lyons, C.R.; Schmid, M.H.

    1995-12-01

    Mycobacterium tuberculosis (Mtb) is an infectious disease that resides in the human lung. Due to the difficulty in completely killing off the disease in infected individuals, Mtb has developed drug-resistant forms and is on the rise in the human population. Therefore, ITRI and the University of New Mexico are collaborating to explore the treatment of Mtb by an aerosolized drug delivered directly to the lungs. In conclusion, it is feasible to obtain an appropriate size and concentration of the liposomes before and after aerosolization.

  11. Photo-synthesis of protein-based nanoparticles and the application in drug delivery

    SciTech Connect (OSTI)

    Xie, Jinbing; Wang, Hongyang; Cao, Yi; Qin, Meng Wang, Wei

    2015-07-15

    Recently, protein-based nanoparticles as drug delivery systems have attracted great interests due to the excellent behavior of high biocompatibility and biodegradability, and low toxicity. However, the synthesis techniques are generally costly, chemical reagents introduced, and especially present difficulties in producing homogeneous monodispersed nanoparticles. Here, we introduce a novel physical method to synthesize protein nanoparticles which can be accomplished under physiological condition only through ultraviolet (UV) illumination. By accurately adjusting the intensity and illumination time of UV light, disulfide bonds in proteins can be selectively reduced and the subsequent self-assembly process can be well controlled. Importantly, the co-assembly can also be dominated when the proteins mixed with either anti-cancer drugs, siRNA, or active targeting molecules. Both in vitro and in vivo experiments indicate that our synthesized protein–drug nanoparticles (drug-loading content and encapsulation efficiency being ca. 8.2% and 70%, respectively) not only possess the capability of traditional drug delivery systems (DDS), but also have a greater drug delivery efficiency to the tumor sites and a better inhibition of tumor growth (only 35% of volume comparing to the natural growing state), indicating it being a novel drug delivery system in tumor therapy.

  12. Roadmap to Achieve Energy Delivery Systems Cybersecurity

    Energy.gov (indexed) [DOE]

    Roadmap to Achieve Energy Delivery Systems Cybersecurity ii Acknowledgements The Energy Sector Control Systems Working Group (ESCSWG) developed this roadmap in support of the ...

  13. Synthetic LDL as targeted drug delivery vehicle

    DOE Patents [OSTI]

    Forte, Trudy M.; Nikanjam, Mina

    2012-08-28

    The present invention provides a synthetic LDL nanoparticle comprising a lipid moiety and a synthetic chimeric peptide so as to be capable of binding the LDL receptor. The synthetic LDL nanoparticle of the present invention is capable of incorporating and targeting therapeutics to cells expressing the LDL receptor for diseases associated with the expression of the LDL receptor such as central nervous system diseases. The invention further provides methods of using such synthetic LDL nanoparticles.

  14. Fiber coupled optical spark delivery system

    DOE Patents [OSTI]

    Yalin, Azer; Willson, Bryan; Defoort, Morgan

    2008-08-12

    A spark delivery system for generating a spark using a laser beam is provided, the spark delivery system including a laser light source and a laser delivery assembly. The laser delivery assembly includes a hollow fiber and a launch assembly comprising launch focusing optics to input the laser beam in the hollow fiber. In addition, the laser delivery assembly includes exit focusing optics that demagnify an exit beam of laser light from the hollow fiber, thereby increasing the intensity of the laser beam and creating a spark. In accordance with embodiments of the present invention, the assembly may be used to create a spark in a combustion engine. In accordance with other embodiments of the present invention, a method of using the spark delivery system is provided. In addition, a method of choosing an appropriate fiber for creating a spark using a laser beam is also presented.

  15. Comments of Cisco Systems to Office of Electricity Delivery and...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    of Cisco Systems to Office of Electricity Delivery and Energy Reliability Comments of Cisco Systems to Office of Electricity Delivery and Energy Reliability Cisco Systems provides ...

  16. Fiber laser coupled optical spark delivery system

    DOE Patents [OSTI]

    Yalin, Azer; Willson, Bryan; Defoort, Morgan; Joshi, Sachin; Reynolds, Adam

    2008-03-04

    A spark delivery system for generating a spark using a laser beam is provided, and includes a laser light source and a laser delivery assembly. The laser delivery assembly includes a hollow fiber and a launch assembly comprising launch focusing optics to input the laser beam in the hollow fiber. The laser delivery assembly further includes exit focusing optics that demagnify an exit beam of laser light from the hollow fiber, thereby increasing the intensity of the laser beam and creating a spark. Other embodiments use a fiber laser to generate a spark. Embodiments of the present invention may be used to create a spark in an engine. Yet other embodiments include collecting light from the spark or a flame resulting from the spark and conveying the light for diagnostics. Methods of using the spark delivery systems and diagnostic systems are provided.

  17. Hydrogen storage and delivery system development

    SciTech Connect (OSTI)

    Handrock, J.L.; Wally, K.; Raber, T.N.

    1995-09-01

    Hydrogen storage and delivery is an important element in effective hydrogen utilization for energy applications and is an important part of the FY1994-1998 Hydrogen Program Implementation Plan. The purpose of this project is to develop a platform for the engineering evaluation of hydrogen storage and delivery systems with an added focus on lightweight hydride utilization. Hybrid vehicles represent the primary application area of interest, with secondary interests including such items as existing vehicles and stationary uses. The near term goal is the demonstration of an internal combustion engine/storage/delivery subsystem. The long term goal is optimization of storage technologies for both vehicular and industrial stationary uses. In this project an integrated approach is being used to couple system operating characteristics to hardware development. A model has been developed which integrates engine and storage material characteristics into the design of hydride storage and delivery systems. By specifying engine operating parameters, as well as a variety of storage/delivery design features, hydride bed sizing calculations are completed. The model allows engineering trade-off studies to be completed on various hydride material/delivery system configurations. A more generalized model is also being developed to allow the performance characteristics of various hydrogen storage and delivery systems to be compared (liquid, activated carbon, etc.). Many of the features of the hydride storage model are applicable to the development of this more generalized model.

  18. Mesoporous Fe{sub 3}O{sub 4}/hydroxyapatite composite for targeted drug delivery

    SciTech Connect (OSTI)

    Gu, Lina; He, Xiaomei; Wu, Zhenyu

    2014-11-15

    Highlights: Mesoporous Fe{sub 3}O{sub 4}/hydroxyapatite composite was synthesized by a simple, efficient and environmental friendly method. The prepared material had a large surface area, high pore volume, and good magnetic separability. DOX-loaded Fe{sub 3}O{sub 4}/hydroxyapatite composite exhibited surprising slow drug release behavior and pH-dependent behavior. - Abstract: In this contribution, we introduced a simple, efficient, and green method of preparing a mesoporous Fe{sub 3}O{sub 4}/hydroxyapatite (HA) composite. The as-prepared material had a large surface area, high pore volume, and good magnetic separability, which made it suitable for targeted drug delivery systems. The chemotherapeutic agent doxorubicin (DOX) was used to investigate the drug release behavior of Fe{sub 3}O{sub 4}/HA composite. The drug release profiles displayed a little burst effect and pH-dependent behavior. The release rate of DOX at pH 5.8 was larger than that at pH 7.4, which could be attributed to DOX protonation in acid medium. In addition, the released DOX concentrations remained at 0.83 and 1.39 ?g/ml at pH 7.4 and 5.8, respectively, which indicated slow, steady, and safe release rates. Therefore, the as-prepared Fe{sub 3}O{sub 4}/hydroxyapatite composite could be an efficient platform for targeted anticancer drug delivery.

  19. Electromagnetic field triggered drug and chemical delivery via liposomes

    DOE Patents [OSTI]

    Liburdy, R.P.

    1993-03-02

    The present invention relates to a system and to a method of delivering a drug to a preselected target body site of a patient, comprising the steps of encapsulating the chemical agent within liposomes, essentially temperature insensitive, i.e. not having a specific predetermined phase transition temperature within the specific temperature range of drug administration; administering the liposomes to the target body site; and subjecting the target body site to nonionizing electromagnetic fields in an area of the preselected target body in order to release the chemical agent from the liposomes at a temperature of between about +10 and 65 C. The invention further relates to the use of the liposomes to bind to the surface of or to enter target tissue or an organ in a living system, and, when subjected to a nonionizing field, to release a drug from the liposomes into the target site.

  20. Electromagnetic field triggered drug and chemical delivery via liposomes

    DOE Patents [OSTI]

    Liburdy, Robert P.

    1993-01-01

    The present invention relates to a system and to a method of delivering a drug to a preselected target body site of a patient, comprising the steps of encapsulating the chemical agent within liposomes, essentially temperature insensitive, i.e. not having a specific predetermined phase transition temperature within the specific temperature range of drug administration; administering the liposomes to the target body site; and subjecting the target body site to nonionizing electromagnetic fields in an area of the preselected target body in order to release said chemical agent from the liposomes at a temperature of between about +10 and 65.degree. C. The invention further relates to the use of said liposomes to bind to the surface of or to enter target tissue or an organ in a living system, and, when subjected to a nonionizing field, to release a drug from the liposomes into the target site.

  1. Patch and Update Management Program for Energy Delivery Systems

    Office of Environmental Management (EM)

    energy delivery system devices for end users and equipment vendors Background The energy sector places an emphasis on the availability and reliability of energy delivery operations. ...

  2. Renewable energy delivery systems and methods

    DOE Patents [OSTI]

    Walker, Howard Andrew

    2013-12-10

    A system, method and/or apparatus for the delivery of energy at a site, at least a portion of the energy being delivered by at least one or more of a plurality of renewable energy technologies, the system and method including calculating the load required by the site for the period; calculating the amount of renewable energy for the period, including obtaining a capacity and a percentage of the period for the renewable energy to be delivered; comparing the total load to the renewable energy available; and, implementing one or both of additional and alternative renewable energy sources for delivery of energy to the site.

  3. Cybersecurity for Energy Delivery Systems | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Cybersecurity » Cybersecurity for Energy Delivery Systems Cybersecurity for Energy Delivery Systems About the Cybersecurity for Energy Delivery Systems Program A key mission of the Department of Energy's (DOE) Office of Electricity Delivery and Energy Reliability (OE) is to enhance the reliability and resilience of the nation's energy infrastructure. Cybersecurity of energy delivery systems is critical for protecting the energy infrastructure and the integral function that it serves in our

  4. Cybersecurity Procurement Language for Energy Delivery Systems

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Cybersecurity Procurement Language for Energy Delivery Systems April 2014 Energy Sector Control Systems Working Group (ESCSWG) i For Questions or Comments Energy sector asset owners, operators, and suppliers are encouraged to provide feedback on this document to enhance the cybersecurity procurement language for future versions. Please send questions or comments to es-pl@energetics.com. Acknowledgements This document was prepared by the Energy Sector Control Systems Working Group (ESCSWG),

  5. Vulnerability Analysis of Energy Delivery Control Systems

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    0-18381 Vulnerability Analysis of Energy Delivery Control Systems September 2011 Idaho National Laboratory Idaho Falls, Idaho 83415 http://www.inl.gov Prepared for the U.S. Department of Energy Office of Electricity Delivery and Energy Reliability Under DOE Idaho Operations Office Contract DE-AC07-05ID14517 The INL is a U.S. Department of Energy National Laboratory operated by Battelle Energy Alliance DISCLAIMER This information was prepared as an account of work sponsored by an agency of the

  6. Photodynamic Therapy of the Canine Prostate: Intra-arterial Drug Delivery

    SciTech Connect (OSTI)

    Moore, Ronald B. Xiao, Zhengwen; Owen, Richard J.; Ashforth, Robert; Dickey, Dwayne; Helps, Cathy; Tulip, John

    2008-01-15

    Purpose. Interstitial photodynamic therapy (PDT) selectively destroys tissue targeted with a photosensitizer and then exposed to light of a specific wavelength. We report a novel delivery method-intra-arterial drug delivery for PDT of the prostate-in a canine model.Methods. To evaluate drug distribution, the prostatovesical artery was selectively cannulated and photosensitizers alone or in conjunction with 99m-technetium-labeled macro-aggregated albumin ({sup 99m}Tc-MAA) were injected via a 3 Fr microcatheter in 8 animals. One dog was followed for 3 months to determine tolerance and toxicity. The remaining animals were euthanized and imaged with whole-body single photon emission CT and gamma counting for radioactivity distribution. Photosensitizer distribution was further analyzed by fluorescence confocal microscopy and tissue chemical extraction. To evaluate PDT, the photosensitizer QLT0074 was infused in 3 animals followed by interstitial illumination with 690 nm laser light. Results. Intra-arterial infusion selectively delivered drugs to the prostate, with both radioactivity and photosensitizer levels significantly higher (up to 18 times) than in the surrounding organs (i.e., rectum). With unilateral injection of {sup 99m}Tc-MAA, only the injected half of the prostate showed activity whereas bilateral administration resulted in drug delivery to the entire prostate. PDT resulted in comprehensive damage to the prostate without severe complications or systemic toxicity. Conclusion. Injection of radiolabeled MAA into the prostatovesical artery results in distribution within the prostate with negligible amounts reaching the adjacent organs. PDT also demonstrates selective damage to the prostate, which warrants clinical application in targeted prostate therapies.

  7. Roadmap to Achieve Energy Delivery Systems Cybersecurity

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Roadmap to Achieve Energy Delivery Systems Cybersecurity ii Acknowledgements The Energy Sector Control Systems Working Group (ESCSWG) developed this roadmap in support of the Electricity Sub-sector Coordinating Council, Oil and Natural Gas Sector Coordinating Council, and the Government Coordinating Council for Energy under the Critical Infrastructure Partnership Advisory Council (CIPAC) Framework; the roadmap has been approved for release by these councils. The ESCSWG members volunteered their

  8. Hydrogen storage and delivery system development: Analysis

    SciTech Connect (OSTI)

    Handrock, J.L.

    1996-10-01

    Hydrogen storage and delivery is an important element in effective hydrogen utilization for energy applications and is an important part of the FY1994-1998 Hydrogen Program Implementation Plan. This project is part of the Field Work Proposal entitled Hydrogen Utilization in Internal Combustion Engines (ICE). The goal of the Hydrogen Storage and Delivery System Development Project is to expand the state-of-the-art of hydrogen storage and delivery system design and development. At the foundation of this activity is the development of both analytical and experimental evaluation platforms. These tools provide the basis for an integrated approach for coupling hydrogen storage and delivery technology to the operating characteristics of potential hydrogen energy use applications. Results of the analytical model development portion of this project will be discussed. Analytical models have been developed for internal combustion engine (ICE) hybrid and fuel cell driven vehicles. The dependence of hydride storage system weight and energy use efficiency on engine brake efficiency and exhaust temperature for ICE hybrid vehicle applications is examined. Results show that while storage system weight decreases with increasing engine brake efficiency energy use efficiency remains relatively unchanged. The development, capability, and use of a recently developed fuel cell vehicle storage system model will also be discussed. As an example of model use, power distribution and control for a simulated driving cycle is presented. Model calibration results of fuel cell fluid inlet and exit temperatures at various fuel cell idle speeds, assumed fuel cell heat capacities, and ambient temperatures are presented. The model predicts general increases in temperature with fuel cell power and differences between inlet and exit temperatures, but under predicts absolute temperature values, especially at higher power levels.

  9. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Software Engineering Institute Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Software Engineering Institute National lab researchers, industry ...

  10. Patch and Update Management Program for Energy Delivery Systems

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Patch and Update Management Program for Energy Delivery Systems A simplified process of patching and updating energy delivery system devices for end users and equipment vendors Background The energy sector places an emphasis on the availability and reliability of energy delivery operations. While best practice avoids the connection of energy delivery system devices to external networks, their increasing interconnectivity poses greater risk to cyber vulnerabilities. Proper and timely patches and

  11. Cybersecurity for Energy Delivery Systems (CEDS) Fact Sheets | Department

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    of Energy (CEDS) Fact Sheets Cybersecurity for Energy Delivery Systems (CEDS) Fact Sheets A key mission of the Department of Energy's (DOE) Office of Electricity Delivery and Energy Reliability (OE) is to enhance the reliability and resilience of the nation's energy infrastructure. Cybersecurity of energy delivery systems is critical for protecting the energy infrastructure and the integral function that it serves in our lives. OE's Cybersecurity for Energy Delivery Systems (CEDS) program

  12. Cybersecurity for Energy Delivery Systems 2010 Peer Review | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energy 2010 Peer Review Cybersecurity for Energy Delivery Systems 2010 Peer Review National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day public peer review to examine more than 30 DOE-supported or cost-shared projects designed to enhance the security and reliability of the nation's energy delivery infrastructure. Industry experts from the Energy

  13. Gas-phase propane fuel delivery system

    SciTech Connect (OSTI)

    Clements, J.

    1991-04-30

    This patent describes a gas-phase fuel delivery system for delivering a vapor phase fuel independent of exterior temperatures. It comprises:a storage tank for storing a volume of fuel; a regulator in fluid communication with the tank for receiving fuel from the tank and for outputting the fuel in a vapor phase; a pressure sensor in fluid communication with the tank for monitoring pressure within the tank, the pressure sensor being operative to generate a pump enable signal when the pressure within the tank is less than a predetermined threshold; a pump in fluid communication with the tank.

  14. Microcalibrator system for chemical signature and reagent delivery...

    Office of Scientific and Technical Information (OSTI)

    Technical Report: Microcalibrator system for chemical signature and reagent delivery. Citation Details In-Document Search Title: Microcalibrator system for chemical signature and ...

  15. Vulnerability Analysis of Energy Delivery Control Systems (September 2011)

    Office of Energy Efficiency and Renewable Energy (EERE)

    The Vulnerability Analysis of Energy Delivery Control Systems report, prepared by Idaho National Laboratory, describes the common vulnerabilities on energy sector control systems, and provides...

  16. Development of Novel Polymeric Materials for Gene Therapy and pH-Sensitive Drug Delivery: Modeling, Synthesis, Characterization, and Analysis

    SciTech Connect (OSTI)

    Brian Curtis Anderson

    2002-08-27

    The underlying theme of this thesis is the use of polymeric materials in bioapplications. Chapters 2-5 either develop a fundamental understanding of current materials used for bioapplications or establish protocols and procedures used in characterizing and synthesizing novel materials. In chapters 6 and 7 these principles and procedures are applied to the development of materials to be used for gene therapy and drug delivery. Chapter one is an introduction to the ideas that will be necessary to understand the subsequent chapters, as well as a literature review of these topics. Chapter two is a paper that has been published in the ''Journal of Controlled Release'' that examines the mechanism of drug release from a polymer gel, as well as experimental design suggestions for the evaluation of water soluble drug delivery systems. Chapter three is a paper that has been published in the ''Journal of Pharmaceutical Sciences'' that discusses the effect ionic salts have on properties of the polymer systems examined in chapter two. Chapter four is a paper published in the Materials Research Society Fall 2000 Symposium Series dealing with the design and synthesis of a pH-sensitive polymeric drug delivery device. Chapter five is a paper that has been published in the journal ''Biomaterials'' proposing a novel polymer/metal composite for use as a biomaterial in hip arthroplasty surgery. Chapter six is a paper that will appear in an upcoming volume of the Journal ''Biomaterials'' dealing with the synthesis of a novel water soluble cationic polymer with possible applications in non-viral gene therapy. Chapter seven is a paper that has been submitted to ''Macromolecules'' discussing several novel block copolymers based on poly(ethylene glycol) and poly(diethylamino ethyl methacrylate) that possess both pH-sensitive and temperature sensitive properties. Chapter eight contains a summary of the research contained in chapters 2-7 and proposes future research for the gene therapy and

  17. Drug delivery from hydrophobic-modified mesoporous silicas: Control...

    Office of Scientific and Technical Information (OSTI)

    on the pore openings and external pore surfaces in the post-grafting modified samples. ... groups on the pore surfaces of the mesostructures strongly affects the drug release rate. ...

  18. Turbomachine injection nozzle including a coolant delivery system

    DOE Patents [OSTI]

    Zuo, Baifang (Simpsonville, SC)

    2012-02-14

    An injection nozzle for a turbomachine includes a main body having a first end portion that extends to a second end portion defining an exterior wall having an outer surface. A plurality of fluid delivery tubes extend through the main body. Each of the plurality of fluid delivery tubes includes a first fluid inlet for receiving a first fluid, a second fluid inlet for receiving a second fluid and an outlet. The injection nozzle further includes a coolant delivery system arranged within the main body. The coolant delivery system guides a coolant along at least one of a portion of the exterior wall and around the plurality of fluid delivery tubes.

  19. Fluid Delivery System For Capillary Electrophoretic Applications.

    DOE Patents [OSTI]

    Li, Qingbo; Liu, Changsheng; Kane, Thomas E.; Kernan, John R.; Sonnenschein, Bernard; Sharer, Michael V.

    2002-04-23

    An automated electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from one side of a plate. The first array of capillary ends are spaced apart in substantially the same manner as the wells of a microtitre tray of standard size. This allows one to simultaneously perform capillary electrophoresis on samples present in each of the wells of the tray. The system includes a stacked, dual carrousel arrangement to eliminate cross-contamination resulting from reuse of the same buffer tray on consecutive executions from electrophoresis. The system also has a gel delivery module containing a gel syringe/a stepper motor or a high pressure chamber with a pump to quickly and uniformly deliver gel through the capillary tubes. The system further includes a multi-wavelength beam generator to generate a laser beam which produces a beam with a wide range of wavelengths. An off-line capillary reconditioner thoroughly cleans a capillary cartridge to enable simultaneous execution of electrophoresis with another capillary cartridge. The streamlined nature of the off-line capillary reconditioner offers the advantage of increased system throughput with a minimal increase in system cost.

  20. Synthesis and characterization of polylactide/doxorubicin/magnetic nanoparticles composites for drug delivery

    SciTech Connect (OSTI)

    Mhlanga, Nikiwe; Ray, Suprakas Sinha

    2015-05-22

    Magnetic iron oxide nanoparticles have potential to transform conventional therapeutics, through targeted delivery by external magnetic field modulation. Conventional drug delivery lacks specificity; both normal and infected cells are exposed to toxic drugs. Consequently, the toxicity towards healthy cells leads to detrimental side effects which are formidable. However, iron oxide research in biomedicine has been hindered by their lack of stability. This study reports on the stabilization of iron oxide by polylactide (PLA). Besides affording stable iron oxide, PLA is also good for sustained delivery of the drug. PLA/doxorubicin/magnetic nanoparticles (PLA/DOX/MNPs) spheres were synthesized by solvent evaporation method and DOX anticancer drug was encapsulated. The spheres were characterized using scanning electron microscope, Fourier transform infrared microscope, thermogravimetric analyzer and UV-visible spectroscopy, which ascertained formation of the anticipated spheres and incorporation of DOX. In vitro drug release studies were carried out in both phosphate buffer (pH 7.4) and acetate buffer (pH 4.6) and they showed the same trend in both mediums. Drug release kinetics followed Higuchi model, which proved drug release by diffusion via a diffusion gradient.

  1. Vulnerability Analysis of Energy Delivery Control Systems- 2011

    Office of Energy Efficiency and Renewable Energy (EERE)

    Cybersecurity for energy delivery systems has emerged as one of the Nation’s most serious grid modernization and infrastructure protection issues. Cyber adversaries are becoming increasingly...

  2. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    PracticesStandards Development Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Best PracticesStandards Development National lab researchers, industry ...

  3. Hydrogen Delivery Technologies and Systems- Pipeline Transmission of Hydrogen

    Energy.gov [DOE]

    Hydrogen Delivery Technologies and Systems - Pipeline Transmission of Hydrogen. Design and operations standards and materials for hydrogen and natural gas pipelines.

  4. Micro injector sample delivery system for charged molecules

    DOE Patents [OSTI]

    Davidson, James C.; Balch, Joseph W.

    1999-11-09

    A micro injector sample delivery system for charged molecules. The injector is used for collecting and delivering controlled amounts of charged molecule samples for subsequent analysis. The injector delivery system can be scaled to large numbers (>96) for sample delivery to massively parallel high throughput analysis systems. The essence of the injector system is an electric field controllable loading tip including a section of porous material. By applying the appropriate polarity bias potential to the injector tip, charged molecules will migrate into porous material, and by reversing the polarity bias potential the molecules are ejected or forced away from the tip. The invention has application for uptake of charged biological molecules (e.g. proteins, nucleic acids, polymers, etc.) for delivery to analytical systems, and can be used in automated sample delivery systems.

  5. Use of supercritical fluid solution expansion processes for drug delivery, particle synthesis, and thin film deposition

    SciTech Connect (OSTI)

    Hybertson, B.M.

    1992-01-01

    Properties of the gases and aerosols resulting from the expansion of supercritical fluid solutions were studied. Film deposition, particle formation, and drug delivery processes using supercritical fluids were developed. Thin films of palladium, copper, aluminum, silver, and silicon dioxide were deposited by a method called supercritical fluid transport-chemical deposition (SFT-CD). In each case, a precursor compound was dissolved in a supercritical fluid and the solution was allowed to expand through a restrictor nozzle into a reaction chamber at subcritical pressure, resulting in the formation of aerosol particles of the precursor. A chemical reaction was induced to occur at the surface of a substrate, resulting in deposition of a thin film. Micron-sized particles of aluminum fluoride and copper oxide were synthesized by a method called supercritical fluid transport-chemical formation of particles (SFT-CFP). The process was similar to that in SFT-CD, but the chemical reactions were induced to occur in the gas phase instead of at a substrate surface, resulting in the formation of fine particles. A new method of pulmonary drug delivery called supercritical fluid drug delivery (SFDD) was conceived and demonstrated. In SFDD a drug compound is dissolved in a supercritical fluid, and the solution is allowed to expand through a restrictor nozzle. The resultant aerosol is directly inhaled by a human or animal subject and the fine drug particles are deposited in the lungs. Menthol, vanillin, camphor, cholesterol, Sudan III, and Oil Blue N were used as model drug compounds for SFDD. Delivery of [alpha]-tocopherol to rat lung tissue was demonstrated, with observed increases of 80-290% above background levels.

  6. Optical diagnostics integrated with laser spark delivery system

    DOE Patents [OSTI]

    Yalin, Azer; Willson, Bryan; Defoort, Morgan; Joshi, Sachin; Reynolds, Adam

    2008-09-02

    A spark delivery system for generating a spark using a laser beam is provided, and includes a laser light source and a laser delivery assembly. The laser delivery assembly includes a hollow fiber and a launch assembly comprising launch focusing optics to input the laser beam in the hollow fiber. The laser delivery assembly further includes exit focusing optics that demagnify an exit beam of laser light from the hollow fiber, thereby increasing the intensity of the laser beam and creating a spark. Other embodiments use a fiber laser to generate a spark. Embodiments of the present invention may be used to create a spark in an engine. Yet other embodiments include collecting light from the spark or a flame resulting from the spark and conveying the light for diagnostics. Methods of using the spark delivery systems and diagnostic systems are provided.

  7. Delivery system for molten salt oxidation of solid waste

    DOE Patents [OSTI]

    Brummond, William A. (Livermore, CA); Squire, Dwight V. (Livermore, CA); Robinson, Jeffrey A. (Manteca, CA); House, Palmer A. (Walnut Creek, CA)

    2002-01-01

    The present invention is a delivery system for safety injecting solid waste particles, including mixed wastes, into a molten salt bath for destruction by the process of molten salt oxidation. The delivery system includes a feeder system and an injector that allow the solid waste stream to be accurately metered, evenly dispersed in the oxidant gas, and maintained at a temperature below incineration temperature while entering the molten salt reactor.

  8. Multiple-robot drug delivery strategy through coordinated teams of microswimmers

    SciTech Connect (OSTI)

    Kei Cheang, U; Kim, Min Jun; Lee, Kyoungwoo; Julius, Anak Agung

    2014-08-25

    Untethered robotic microswimmers are very promising to significantly improve various types of minimally invasive surgeries by offering high accuracy at extremely small scales. A prime example is drug delivery, for which a large number of microswimmers is required to deliver sufficient dosages to target sites. For this reason, the controllability of groups of microswimmers is essential. In this paper, we demonstrate simultaneous control of multiple geometrically similar but magnetically different microswimmers using a single global rotating magnetic field. By exploiting the differences in their magnetic properties, we triggered different swimming behaviors from the microswimmers by controlling the frequency and the strength of the global field, for example, one swim and the other does not while exposed to the same control input. Our results show that the balance between the applied magnetic torque and the hydrodynamic torque can be exploited for simultaneous control of two microswimmers to swim in opposite directions, with different velocities, and with similar velocities. This work will serve to establish important concepts for future developments of control systems to manipulate multiple magnetically actuated microswimmers and a step towards using swarms of microswimmers as viable workforces for complex operations.

  9. Tank Waste Feed Delivery System Readiness at the Hanford Site

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Audit Report Tank Waste Feed Delivery System Readiness at the Hanford Site OAS-L-12-09 August 2012 Department of Energy Washington, DC 20585 August 23, 2012 MEMORANDUM FOR THE MANAGER, OFFICE OF RIVER PROTECTION FROM: David Sedillo, Director Western Audits Division Office of Audits and Inspections Office of Inspector General SUBJECT: INFORMATION: Audit Report on "Tank Waste Feed Delivery System Readiness at the Hanford Site" BACKGROUND The Department of Energy's largest cleanup task

  10. Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC Intergrated Drug Testing System, PIA, Bechtel ...

  11. Waste feed delivery program systems engineering implementation plan

    SciTech Connect (OSTI)

    O`Toole, S.M.

    1998-09-24

    This document defines the systems engineering processes and products planned by the Waste Feed Delivery Program to develop the necessary and sufficient systems to provide waste feed to the Privatization Contractor for Phase 1. It defines roles and responsibilities for the performance of the systems engineering processes and generation of products.

  12. Thermal safety of ultrasound-enhanced ocular drug delivery: A modeling study

    SciTech Connect (OSTI)

    Nabili, Marjan; Geist, Craig E-mail: zderic@gwu.edu; Zderic, Vesna E-mail: zderic@gwu.edu

    2015-10-15

    Purpose: Delivery of sufficient amounts of therapeutic drugs into the eye for treatment of various ocular diseases is often a challenging task. Ultrasound was shown to be effective in enhancing ocular drug delivery in the authors’ previous in vitro and in vivo studies. Methods: The study reported here was designed to investigate the safety of ultrasound application and its potential thermal effects in the eye using PZFlex modeling software. The safety limit in this study was set as a temperature increase of no more than 1.5 °C based on regulatory recommendations and previous experimental safety studies. Acoustic and thermal specifications of different human eye tissues were obtained from the published literature. The tissues of particular interest in this modeling safety study were cornea, lens, and the location of optic nerve in the posterior eye. Ultrasound application was modeled at frequencies of 400 kHz–1 MHz, intensities of 0.3–1 W/cm{sup 2}, and exposure duration of 5 min, which were the parameters used in the authors’ previous drug delivery experiments. The baseline eye temperature was 37 °C. Results: The authors’ results showed that the maximal tissue temperatures after 5 min of ultrasound application were 38, 39, 39.5, and 40 °C in the cornea, 39.5, 40, 42, and 43 °C in the center of the lens, and 37.5, 38.5, and 39 °C in the back of the eye (at the optic nerve location) at frequencies of 400, 600, 800 kHz, and 1 MHz, respectively. Conclusions: The ocular temperatures reached at higher frequencies were considered unsafe based on current recommendations. At a frequency of 400 kHz and intensity of 0.8 W/cm{sup 2} (parameters shown in the authors’ previous in vivo studies to be optimal for ocular drug delivery), the temperature increase was small enough to be considered safe inside different ocular tissues. However, the impact of orbital bone and tissue perfusion should be included in future modeling efforts to determine the safety

  13. Toward new solid and liquid phase systems for the containment, transport and delivery of hydrogen

    Energy.gov [DOE]

    Toward new solid and liquid phase systems for the containment, transport and delivery of hydrogen.Solid and liquid hydrogen carriers for use in hydrogen storage and delivery.

  14. FREQUENTLY ASKED QUESTIONS (FAQs) CYBERSECURITY ENERGY DELIVERY SYSTEMS (CEDS)

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    FREQUENTLY ASKED QUESTIONS (FAQs) CYBERSECURITY ENERGY DELIVERY SYSTEMS (CEDS) 2016 PEER REVIEW 1 GENERAL QUESTIONS 1. When is the 2016 CEDS Peer Review? The U.S. Department of Energy (DOE) Cybersecurity for Energy Delivery Systems (CEDS) 2016 Peer Review will take place at the Hyatt Regency Crystal City at Reagan National Airport in Arlington, VA on December 7-9, 2016. 2. I have been invited to present at the Peer Review. Do members of my organization need to register for the event? All

  15. Vulnerability Analysis of Energy Delivery Control Systems

    Office of Environmental Management (EM)

    than the adversary can launch new attack tools and techniques. "Industry estimates that ... These tools allow a qualitative analysis of the vulnerabilities found in control systems ...

  16. Cybersecurity Procurement Language for Energy Delivery Systems

    Energy Savers

    ... Malicious code can enter systems through ...telecom-info.telcordia.comsite-cgiidodocs.cgi?IDSEARCH&DOCUMENTGR- 1089&. ... sources for common terms and definitions ...

  17. Mercury sorbent delivery system for flue gas

    DOE Patents [OSTI]

    Klunder; ,Edgar B.

    2009-02-24

    The invention presents a device for the removal of elemental mercury from flue gas streams utilizing a layer of activated carbon particles contained within the filter fabric of a filter bag for use in a flue gas scrubbing system.

  18. Electro fluido dynamic techniques to design instructive biomaterials for tissue engineering and drug delivery

    SciTech Connect (OSTI)

    Guarino, Vincenzo Altobelli, Rosaria; Cirillo, Valentina; Ambrosio, Luigi

    2015-12-17

    A large variety of processes and tools is continuously investigated to discover new solutions to design instructive materials with controlled chemical, physical and biological properties for tissue engineering and drug delivery. Among them, electro fluido dynamic techniques (EFDTs) are emerging as an interesting strategy, based on highly flexible and low-cost processes, to revisit old biomaterial’s manufacturing approach by utilizing electrostatic forces as the driving force for the fabrication of 3D architectures with controlled physical and chemical functionalities to guide in vitro and in vivo cell activities. By a rational selection of polymer solution properties and process conditions, EFDTs allow to produce fibres and/or particles at micro and/or nanometric size scale which may be variously assembled by tailored experimental setups, thus giving the chance to generate a plethora of different 3D devices able to incorporate biopolymers (i.e., proteins, polysaccharides) or active molecules (e.g., drugs) for different applications. Here, we focus on the optimization of basic EFDTs - namely electrospinning, electrospraying and electrodynamic atomization - to develop active platforms (i.e., monocomponent, protein and drug loaded scaffolds and µ-scaffolds) made of synthetic (PCL, PLGA) or natural (chitosan, alginate) polymers. In particular, we investigate how to set materials and process parameters to impart specific morphological, biochemical or physical cues to trigger all the fundamental cell–biomaterial and cell– cell cross-talking elicited during regenerative processes, in order to reproduce the complex microenvironment of native or pathological tissues.

  19. Direct current power delivery system and method

    DOE Patents [OSTI]

    Zhang, Di; Garces, Luis Jose; Dai, Jian; Lai, Rixin

    2016-09-06

    A power transmission system includes a first unit for carrying out the steps of receiving high voltage direct current (HVDC) power from an HVDC power line, generating an alternating current (AC) component indicative of a status of the first unit, and adding the AC component to the HVDC power line. Further, the power transmission system includes a second unit for carrying out the steps of generating a direct current (DC) voltage to transfer the HVDC power on the HVDC power line, wherein the HVDC power line is coupled between the first unit and the second unit, detecting a presence or an absence of the added AC component in the HVDC power line, and determining the status of the first unit based on the added AC component.

  20. Miniature Videoprobe Hockey Stick Delivery System

    SciTech Connect (OSTI)

    Hale, Lester R.; McMurry, Kyle M.

    1998-06-18

    The present invention is a miniature videoprobe system having a probe termination box, a strong back, and a videoprobe housing. The videoprobe system is able to obtain images from a restricted space at least as small as 0.125 inches while producing a high quality image. The strong back has a hockey stick shape with the probe termination box connecting to the top of the handle-like portion of the hockey stick and the videoprobe housing attaching to the opposite end or nose of the hockey stick shape. The videoprobe housing has a roughly arrowhead shape with two thin steel plates sandwiching the internal components there between. The internal components are connected in series to allow for a minor dimension of the videoprobe housing of 0.110 inches. The internal components include an optics train, a CCD chip, and an electronics package. An electrical signal is transmitted from the electronics package through wiring within an internal channel of the strong back to the probe termination box. The strong back has milled into it multiple internal channels for facilitating the transfer of information, items, or devices between the probe termination box and the videoprobe housing.

  1. Graphene nanoribbons as a drug delivery agent for lucanthone mediated therapy of glioblastoma multiforme

    SciTech Connect (OSTI)

    Chowdhury, Sayan Mullick; Surhland, Cassandra; Sanchez, Zina; Chaudhary, Pankaj; Suresh Kumar, M. A.; Lee, Stephen; Peña, Louis A.; Waring, Michael; Sitharaman, Balaji; Naidu, Mamta

    2014-08-13

    We report use of PEG-DSPE coated oxidized graphene nanoribbons (O-GNR-PEG-DSPE) as agent for delivery of anti-tumor drug Lucanthone (Luc) into Glioblastoma Multiformae (GBM) cells targeting base excision repair enzyme APE-1 (Apurinic endonuclease-1). Lucanthone, an endonuclease inhibitor of APE-1, was loaded onto O-GNR-PEG-DSPEs using a simple non-covalent method. We found its uptake by GBM cell line U251 exceeding 67% and 60% in APE-1-overexpressing U251, post 24 hours (h). However, their uptake was ~38% and 29% by MCF-7 and rat glial progenitor cells (CG-4), respectively. TEM analysis of U251 showed large aggregates of O-GNR-PEG-DSPE in vesicles. Luc-O-GNR-PEG-DSPE was significantly toxic to U251 but showed little / no toxicity when exposed to MCF-7/CG-4 cells. This differential uptake effect can be exploited to use O-GNR-PEG-DSPEs as a vehicle for Luc delivery to GBM, while reducing nonspecific cytotoxicity to the surrounding healthy tissue. In conclusion, cell death in U251 was necrotic, probably due to oxidative degradation of APE-1.

  2. Graphene nanoribbons as a drug delivery agent for lucanthone mediated therapy of glioblastoma multiforme

    DOE PAGES-Beta [OSTI]

    Chowdhury, Sayan Mullick; Surhland, Cassandra; Sanchez, Zina; Chaudhary, Pankaj; Suresh Kumar, M. A.; Lee, Stephen; Peña, Louis A.; Waring, Michael; Sitharaman, Balaji; Naidu, Mamta

    2014-08-13

    We report use of PEG-DSPE coated oxidized graphene nanoribbons (O-GNR-PEG-DSPE) as agent for delivery of anti-tumor drug Lucanthone (Luc) into Glioblastoma Multiformae (GBM) cells targeting base excision repair enzyme APE-1 (Apurinic endonuclease-1). Lucanthone, an endonuclease inhibitor of APE-1, was loaded onto O-GNR-PEG-DSPEs using a simple non-covalent method. We found its uptake by GBM cell line U251 exceeding 67% and 60% in APE-1-overexpressing U251, post 24 hours (h). However, their uptake was ~38% and 29% by MCF-7 and rat glial progenitor cells (CG-4), respectively. TEM analysis of U251 showed large aggregates of O-GNR-PEG-DSPE in vesicles. Luc-O-GNR-PEG-DSPE was significantly toxic to U251more » but showed little / no toxicity when exposed to MCF-7/CG-4 cells. This differential uptake effect can be exploited to use O-GNR-PEG-DSPEs as a vehicle for Luc delivery to GBM, while reducing nonspecific cytotoxicity to the surrounding healthy tissue. In conclusion, cell death in U251 was necrotic, probably due to oxidative degradation of APE-1.« less

  3. Feasibility Study: Ductless Hydronic Distribution Systems with Fan Coil Delivery

    SciTech Connect (OSTI)

    Springer, D.; Dakin, B.; Backman, C.

    2012-07-01

    The primary objectives of this study are to estimate potential energy savings relative to conventional ducted air distribution, and to identify equipment requirements, costs, and barriers with a focus on ductless hydronic delivery systems that utilize water-to-air terminal units in each zone. Results indicate that annual heating and cooling energy use can be reduced by up to 27% assuming replacement of the conventional 13 SEER heat pump and coil with a similarly rated air-to-water heat pump.

  4. A ferromagnetic compound with anti-cancer proeprties for controlled drug delivery and imaging

    SciTech Connect (OSTI)

    Eguchi, Haruki; Hirata, Kunio; Kurotani, Reiko; Singh, David J.; Fukumura, Hidenobu; Umemura, Masanari; Hoshino, Yujiro; Lee, Jin; Masuda, Takatsugu; Amemiya, Naoyuki; Yamamoto, Masahiro; Sato, Itaru; Feng, Xianfeng; Sato, Motohiko; Inoue, Seiichi; Yamamoto, Masaki; Aoki, Ichio; Tanigaki, Katsumi; Sato, Mamoru; Ishikawa, Yoshihiro

    2015-03-17

    New anticancer agents and modalities for their use are of great interest. Recent studies have demonstrated the presence of anti-cancer properties in salen derivatives. We found that an iron salen derivative, i.e., [Fe(salen)]2O, displays ferromagnetic order above room temperature and shows spontaneous field-dependent magnetization and hysteresis. Understanding of this magnetic property is provided by first-principles calculations based on structures obtained by X-ray crystallography. [Fe(salen)]2O exhibited potent anti-cancer properties against various cancer cell types and was readily attracted by even moderate-strength permanent magnets in vitro. We demonstrated that the delivery of [Fe(salen)]2O to melanoma tissues transplanted into the tails of mice using a permanent magnet leads to a robust decrease in tumor size. The local accumulation of [Fe(salen)]2O was visualized by MRI. Thus, [Fe(salen)]2O acted as an anti-cancer and MRI contrast compound that has a pharmacological effect that is delivered in a controlled manner, suggesting new strategies for anti-cancer drug development.

  5. A ferromagnetic compound with anti-cancer proeprties for controlled drug delivery and imaging

    DOE PAGES-Beta [OSTI]

    Eguchi, Haruki; Hirata, Kunio; Kurotani, Reiko; Singh, David J.; Fukumura, Hidenobu; Umemura, Masanari; Hoshino, Yujiro; Lee, Jin; Masuda, Takatsugu; Amemiya, Naoyuki; et al

    2015-03-17

    New anticancer agents and modalities for their use are of great interest. Recent studies have demonstrated the presence of anti-cancer properties in salen derivatives. We found that an iron salen derivative, i.e., [Fe(salen)]2O, displays ferromagnetic order above room temperature and shows spontaneous field-dependent magnetization and hysteresis. Understanding of this magnetic property is provided by first-principles calculations based on structures obtained by X-ray crystallography. [Fe(salen)]2O exhibited potent anti-cancer properties against various cancer cell types and was readily attracted by even moderate-strength permanent magnets in vitro. We demonstrated that the delivery of [Fe(salen)]2O to melanoma tissues transplanted into the tails of micemore » using a permanent magnet leads to a robust decrease in tumor size. The local accumulation of [Fe(salen)]2O was visualized by MRI. Thus, [Fe(salen)]2O acted as an anti-cancer and MRI contrast compound that has a pharmacological effect that is delivered in a controlled manner, suggesting new strategies for anti-cancer drug development.« less

  6. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations- Best Practices/Standards Development

    Energy.gov [DOE]

    National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day...

  7. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations- Visualization and Modeling

    Office of Energy Efficiency and Renewable Energy (EERE)

    National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day...

  8. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations- Secure Communications

    Office of Energy Efficiency and Renewable Energy (EERE)

    National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day...

  9. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations- Best Practice Design/Configuration

    Energy.gov [DOE]

    National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day...

  10. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations- Software Engineering Institute

    Energy.gov [DOE]

      National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2...

  11. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations- Vulnerability and Intrusion Detection

    Energy.gov [DOE]

    National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day...

  12. Reliability review of the remote tool delivery system locomotor

    SciTech Connect (OSTI)

    Chesser, J.B.

    1999-04-01

    The locomotor being built by RedZone Robotics is designed to serve as a remote tool delivery (RID) system for waste retrieval, tank cleaning, viewing, and inspection inside the high-level waste tanks 8D-1 and 8D-2 at West Valley Nuclear Services (WVNS). The RTD systm is to be deployed through a tank riser. The locomotor portion of the RTD system is designed to be inserted into the tank and is to be capable of moving around the tank by supporting itself and moving on the tank internal structural columns. The locomotor will serve as a mounting platform for a dexterous manipulator arm. The complete RTD system consists of the locomotor, dexterous manipulator arm, cameras, lights, cables, hoses, cable/hose management system, power supply, and operator control station.

  13. Diagnosing delivery problems in the White House Information Distribution System

    SciTech Connect (OSTI)

    Nahabedian, M.; Shrobe, H.

    1996-12-31

    As part of a collaboration with the White House Office of Media Affairs, members of the MIT Artificial Intelligence Laboratory designed a system, called COMLINK, which distributes a daily stream of documents released by the Office of Media Affairs. Approximately 4000 direct subscribers receive information from this service but more than 100,000 people receive the information through redistribution channels. The information is distributed via Email and the World Wide Web. In such a large scale distribution scheme, there is a constant problem of subscriptions becoming invalid because the user`s Email account has terminated. This causes a backwash of hundreds of {open_quotes}bounced mail{close_quotes} messages per day which must be processed by the operators of the COMLINK system. To manage this annoying but necessary task, an expert system named BMES was developed to diagnose the failures of information delivery.

  14. Comments of Cisco Systems to Office of Electricity Delivery and Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Reliability | Department of Energy of Cisco Systems to Office of Electricity Delivery and Energy Reliability Comments of Cisco Systems to Office of Electricity Delivery and Energy Reliability Cisco Systems provides comments in response to the RFI issued by DOE on addressing policy andlogistical challenges to smart grid implementation. Comments of Cisco Systems to Office of Electricity Delivery and Energy Reliability (68.83 KB) More Documents & Publications NIST Activities in Support of

  15. Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, LLC (233.03 KB) More Documents & Publications Electronic Document Management System PIA, BechtelJacobs Company, LLC Dosimetry Records System PIA, bechtel Jacobs Company, LLC Pension Estimate System PIA,

  16. Rapid cycling medical synchrotron and beam delivery system

    DOE Patents [OSTI]

    Peggs, Stephen G. (Port Jefferson, NY); Brennan, J. Michael (East Northport, NY); Tuozzolo, Joseph E. (Sayville, NY); Zaltsman, Alexander (Commack, NY)

    2008-10-07

    A medical synchrotron which cycles rapidly in order to accelerate particles for delivery in a beam therapy system. The synchrotron generally includes a radiofrequency (RF) cavity for accelerating the particles as a beam and a plurality of combined function magnets arranged in a ring. Each of the combined function magnets performs two functions. The first function of the combined function magnet is to bend the particle beam along an orbital path around the ring. The second function of the combined function magnet is to focus or defocus the particle beam as it travels around the path. The radiofrequency (RF) cavity is a ferrite loaded cavity adapted for high speed frequency swings for rapid cycling acceleration of the particles.

  17. Multiple delivery cesium oven system for negative ion sources

    SciTech Connect (OSTI)

    Bansal, G.; Bhartiya, S.; Pandya, K.; Bandyopadhyay, M.; Singh, M. J.; Soni, J.; Gahlaut, A.; Parmar, K. G.; Chakraborty, A. [Institute for Plasma Research, Bhat, Gandhinagar, Gujarat 382428 (India)

    2012-02-15

    Distribution of cesium in large negative ion beam sources to be operational in ITER, is presently based on the use of three or more cesium ovens, which operate simultaneously and are controlled remotely. However, use of multiple Cs ovens simultaneously is likely to pose difficulties in operation and maintenance of the ovens. An alternate method of Cs delivery, based on a single oven distribution system is proposed as one which could reduce the need of simultaneous operation of many ovens. A proof of principle experiment verifying the concept of a multinozzle distributor based Cs oven has been carried out at Institute for Plasma Research. It is also observed that the Cs flux is not controlled by Cs reservoir temperature after few hours of operation but by the temperature of the distributor which starts behaving as a Cs reservoir.

  18. Biomanufacturing and self-propulsion dynamics of nanoscale bacteria-enabled autonomous delivery systems

    SciTech Connect (OSTI)

    Traore, Mahama A.; Behkam, Bahareh; Damico, Carmen M.

    2014-10-27

    Flagellated bacteria have superb self-propulsion capabilities and are able to effectively move through highly viscous fluid and semi-solid (porous) environments. This innate aptitude has been harvested for whole-cell actuation of bio-hybrid microrobotic systems with applications in directed transport and microassembly. In this work, we present the biomanufacturing of Nanoscale Bacteria-Enabled Autonomous Delivery Systems (NanoBEADS) by controlled self-assembly and investigate the role of nanoparticle load on the dynamics of their self-propulsion in aqueous environments. Each NanoBEADS agent is comprised of spherical polystyrene nanoparticles assembled onto the body of a flagellated Escherichia coli bacterium. We demonstrate that the NanoBEADS assembly configuration is strongly dependent upon the nanoparticles to bacteria ratio. Furthermore, we characterized the stochastic motion of the NanoBEADS as a function of the quantity and size of the nanoparticle load and computationally analyzed the effect of the nanoparticle load on the experienced drag force. We report that the average NanoBEADS swimming speed is reduced to 65% of the free-swimming bacteria speed (31 μm/s) at the highest possible load. NanoBEADS can be utilized as single agents or in a collaborative swarm in order to carry out specific tasks in a wide range of applications ranging from drug delivery to whole cell biosensing.

  19. Cesium Delivery System for Negative Ion Source at IPR

    SciTech Connect (OSTI)

    Bansal, G.; Pandya, K.; Soni, J.; Gahlaut, A.; Parmar, K. G. [Institute for Plasma Research, Bhat, Gandhinagar, Gujarat, 382 428 (India); Bandyopadhyay, M.; Chakraborty, A.; Singh, M. J. [ITER- India, Institute for Plasma Research, A-29, Sector 25, GIDC, Gandhinagar, Gujarat (India)

    2011-09-26

    The technique of surface production of negative ions using cesium, Cs, has been efficiently exploited over the years for producing negative ion beams with increased current densities from negative ion sources used on neutral beam lines. Deposition of Cs on the source walls and the plasma grid lowers the work function and therefore enables a higher yield of H{sup -}, when hydrogen particles (H and/or H{sub x}{sup +}) strike these surfaces.A single driver RF based (100 kW, 1 MHz) negative ion source test bed, ROBIN, is being set up at IPR under a technical collaboration between IPR and IPP, Germany. The optimization of the Cs oven design to be used on this facility as well as multidriver sources is underway. The characterization experiments of such a Cs delivery system with a 1 g Cs inventory have been carried out using surface ionization technique. The experiments have been carried by delivering Cs into a vacuum chamber without plasma. The linear motion of the surface ionization detector, SID, attached with a linear motion feedthrough allows measuring the angular distribution of the Cs coming out of the oven. Based on the experimental results, a Cs oven for ROBIN has been proposed. The Cs oven design and experimental results of the prototype Cs oven are reported and discussed in the paper.

  20. A "Plug-n-Play" Air Delivery System for Low-Load Homes and Evaluation...

    Energy Savers

    A "Plug-n-Play" Air Delivery System for Low-Load Homes and Evaluation of a Residential Thermal Comfort Rating Method Traditional air distribution system. Graphic courtesy of ...

  1. MO-G-BRE-01: A Real-Time Virtual Delivery System for Photon Radiotherapy Delivery Monitoring

    SciTech Connect (OSTI)

    Shi, F; Gu, X; Jiang, S; Jia, X; Graves, Y

    2014-06-15

    Purpose: Treatment delivery monitoring is important for radiotherapy, which enables catching dosimetric error at the earliest possible opportunity. This project develops a virtual delivery system to monitor the dose delivery process of photon radiotherapy in real-time using GPU-based Monte Carlo (MC) method. Methods: The simulation process consists of 3 parallel CPU threads. A thread T1 is responsible for communication with a linac, which acquires a set of linac status parameters, e.g. gantry angles, MLC configurations, and beam MUs every 20 ms. Since linac vendors currently do not offer interface to acquire data in real time, we mimic this process by fetching information from a linac dynalog file at the set frequency. Instantaneous beam fluence map (FM) is calculated. A FM buffer is also created in T1 and the instantaneous FM is accumulated to it. This process continues, until a ready signal is received from thread T2 on which an inhouse developed MC dose engine executes on GPU. At that moment, the accumulated FM is transferred to T2 for dose calculations, and the FM buffer in T1 is cleared. Once the calculation finishes, the resulting 3D dose distribution is directed to thread T3, which displays it in three orthogonal planes overlaid on the CT image for treatment monitoring. This process continues to monitor the 3D dose distribution in real-time. Results: An IMRT and a VMAT cases used in our patient-specific QA are studied. Maximum dose differences between our system and treatment planning system are 0.98% and 1.58% for the two cases, respectively. The average time per MC calculation is 0.1sec with <2% relative uncertainty. The update frequency of ∼10Hz is considered as real time. Conclusion: By embedding a GPU-based MC code in a novel data/work flow, it is possible to achieve real-time MC dose calculations to monitor delivery process.

  2. Safe and compact ammonia storage/delivery systems for SCR-DeNOX in

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    automotive units | Department of Energy Safe and compact ammonia storage/delivery systems for SCR-DeNOX in automotive units Safe and compact ammonia storage/delivery systems for SCR-DeNOX in automotive units Presentation given at DEER 2006, August 20-24, 2006, Detroit, Michigan. Sponsored by the U.S. DOE's EERE FreedomCar and Fuel Partnership and 21st Century Truck Programs. 2006_deer_johannessen.pdf (14.14 MB) More Documents & Publications Ammonia storage and delivery systems for NOx

  3. Post-Delivery test report for light duty utility arm high resolution stereoscopic video system (HRSVS)

    SciTech Connect (OSTI)

    Pardini, A.F., Westinghouse Hanford

    1996-05-07

    This report documents the post delivery testing of the High Resolution Stereoscopic Video Camera System (HRSVS) LDUA system,designed for use by the Light Duty Utility Arm (LDUA) project.The post delivery test shows by demonstration that the high resolution stereoscopic video camera system is fully operational to perform the task of aligning the LDUA arm and mast with the entry riser during deployment operations within a Hanford Site waste tank.

  4. Post delivery test report for light duty utility arm optical alignment system (OAS)

    SciTech Connect (OSTI)

    Pardini, A.F.

    1996-04-18

    This report documents the post delivery testing of the Optical Alignment System (OAS) LDUA system, designed for use by the Light Duty Utility Arm (LDUA) project. The post delivery test shows by demonstration that the optical alignment system is fully operational to perform the task of aligning the LDUA arm and mast with the entry riser during deployment operations within a Hanford Site waste tank.

  5. USER S GUIDE FOR THE RANDOM DRUG SCREENING SYSTEM

    SciTech Connect (OSTI)

    McNeany, Karen I

    2013-12-01

    The Random Drug Screening System (RDSS) is a desktop computing application designed to assign nongameable drug testing dates to each member in a population of employees, within a specific time line. The program includes reporting capabilities, test form generation, unique test ID number assignment, and the ability to flag high-risk employees for a higher frequency of drug testing than the general population.

  6. Cybersecurity for Energy Delivery Systems (CEDS) Peer Review to Be Held

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    December 7-9, 2016 | Department of Energy Peer Review to Be Held December 7-9, 2016 Cybersecurity for Energy Delivery Systems (CEDS) Peer Review to Be Held December 7-9, 2016 November 10, 2016 - 10:43am Addthis The Office of Electricity Delivery and Energy Reliability (OE) will hold a peer review of its Cybersecurity for Energy Delivery Systems (CEDS) Program research and development projects on December 7-9, 2016 at the Hyatt Regency Crystal City in Arlington, VA. This event will be open to

  7. Tank waste remediation system retrieval and disposal mission waste feed delivery plan

    SciTech Connect (OSTI)

    Potter, R.D.

    1998-01-08

    This document is a plan presenting the objectives, organization, and management and technical approaches for the Waste Feed Delivery (WFD) Program. This WFD Plan focuses on the Tank Waste Remediation System (TWRS) Project`s Waste Retrieval and Disposal Mission.

  8. Chapter 7: Advancing Systems and Technologies to Produce Cleaner Fuels | Natural Gas Delivery Infrastructure Technology Assessment

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Infrastructure Offshore Safety and Spill Prevention Unconventional Oil and Gas ENERGY U.S. DEPARTMENT OF Quadrennial Technology Review 2015 1 Quadrennial Technology Review 2015 Natural Gas Delivery Infrastructure Chapter 7: Technology Assessments Introduction and Background The U.S. natural gas delivery system is an extensive network composed of over 315,000 miles of transmission pipeline and over 2.1 million miles of distribution mains. 1 In 2015, this system moved over 25 trillion cubic feet

  9. Cybersecurity for Energy Delivery Systems (CEDS) Contact Information: For More Information:

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Lori Ross O'Neil Principal Investigator Pacific Northwest National Laboratory * http://energy.gov/oe/technology- development/energy-delivery- systems-cybersecurity 202-586-3247 509-375-6702 * www.controlsystemsroadmap.net carol.hawk@hq.doe.gov lro@pnnl.gov Understanding the Special Case of Digital Forensics in EDS Making Live Analysis work for Energy Delivery Systems Background In digital forensics forums, the idea of Live analysis is gaining momentum. Taking an image of an Information

  10. Targeted Delivery of Drugs to Brain Tumors (LBNL Summer Lecture Series)

    SciTech Connect (OSTI)

    Forte, Trudy

    2007-06-27

    Summer Lecture Series 2007: Trudy Forte of Berkeley Lab's Life Sciences Division will discuss her work developing nano-sized low-density lipoprotein (LDL) particles that can be used as a safe and effective means of delivering anticancer drugs to brain tumors, particularly glioblastoma multiforme. This is the most common malignant brain tumor in adults and one of the deadliest forms of cancer. Her research team found that the synthetic LDL particles can target and kill such tumors cells in vitro. The nanoparticles are composed of a lipid core surrounded by a peptide. The peptide contains an amino acid sequence that recognizes the LDL receptor, and the lipid core has the ability to accumulate anti-cancer drugs.

  11. Targeted Delivery of Drugs to Brain Tumors (LBNL Summer Lecture Series)

    ScienceCinema (OSTI)

    Forte, Trudy

    2016-07-12

    Summer Lecture Series 2007: Trudy Forte of Berkeley Lab's Life Sciences Division will discuss her work developing nano-sized low-density lipoprotein (LDL) particles that can be used as a safe and effective means of delivering anticancer drugs to brain tumors, particularly glioblastoma multiforme. This is the most common malignant brain tumor in adults and one of the deadliest forms of cancer. Her research team found that the synthetic LDL particles can target and kill such tumors cells in vitro. The nanoparticles are composed of a lipid core surrounded by a peptide. The peptide contains an amino acid sequence that recognizes the LDL receptor, and the lipid core has the ability to accumulate anti-cancer drugs.

  12. Cybersecurity for Energy Delivery Systems (CEDS) Research Call

    Energy.gov [DOE]

    The Department of Energy's (DOE) National Energy Technology Laboratory (NETL), on behalf of the Office of Electricity Delivery and Energy Reliability (OE), is seeking applications to conduct research, development and demonstrations leading to next generation tools and technologies that will become widely adopted to enhance and accelerate deployment of cybersecurity capabilities for the U.S energy infrastructure, including cyber secure integration of smart grid technologies.

  13. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations- Trustworthy Cyber Infrastructure for the Power Grid (TCIPG)

    Office of Energy Efficiency and Renewable Energy (EERE)

    National lab researchers, industry partners, and academia from the Cybersecurity for Energy Delivery Systems Program in the DOE's Office of Electricity Delivery and Energy Reliability held a 2-day...

  14. Control system and method for a power delivery system having a continuously variable ratio transmission

    DOE Patents [OSTI]

    Frank, A.A.

    1984-07-10

    A control system and method for a power delivery system, such as in an automotive vehicle, having an engine coupled to a continuously variable ratio transmission (CVT). Totally independent control of engine and transmission enable the engine to precisely follow a desired operating characteristic, such as the ideal operating line for minimum fuel consumption. CVT ratio is controlled as a function of commanded power or torque and measured load, while engine fuel requirements (e.g., throttle position) are strictly a function of measured engine speed. Fuel requirements are therefore precisely adjusted in accordance with the ideal characteristic for any load placed on the engine. 4 figs.

  15. Control system and method for a power delivery system having a continuously variable ratio transmission

    DOE Patents [OSTI]

    Frank, Andrew A.

    1984-01-01

    A control system and method for a power delivery system, such as in an automotive vehicle, having an engine coupled to a continuously variable ratio transmission (CVT). Totally independent control of engine and transmission enable the engine to precisely follow a desired operating characteristic, such as the ideal operating line for minimum fuel consumption. CVT ratio is controlled as a function of commanded power or torque and measured load, while engine fuel requirements (e.g., throttle position) are strictly a function of measured engine speed. Fuel requirements are therefore precisely adjusted in accordance with the ideal characteristic for any load placed on the engine.

  16. SU-D-201-04: Study On the Impact of Tumor Shape and Size On Drug Delivery to Pancreatic Tumors

    SciTech Connect (OSTI)

    Soltani, M; Bazmara, H; Sefidgar, M; Subramaniam, R; Rahmim, A

    2015-06-15

    Purpose: Drug delivery to solid tumors can be expressed physically using transport phenomena such as convection and diffusion for the drug of interest within extracellular matrices. We aimed to carefully model these phenomena, and to investigate the effect of tumor shape and size on drug delivery to solid tumors in the pancreas. Methods: In this study, multiple tumor geometries as obtained from clinical PET/CT images were considered. An advanced numerical method was used to simultaneously solve fluid flow and solute transport equations. Data from n=45 pancreatic cancer patients with non-resectable locoregional disease were analyzed, and geometrical information from the tumors including size, shape, and aspect ratios were classified. To investigate effect of tumor shape, tumors with similar size but different shapes were selected and analyzed. Moreover, to investigate effect of tumor size, tumors with similar shapes but different sizes, ranging from 1 to 77 cm{sup 3}, were selected and analyzed. A hypothetical tumor similar to one of the analyzed tumors, but scaled to reduce its size below 0.2 cm{sup 3}, was also analyzed. Results: The results showed relatively similar average drug concentration profiles in tumors with different sizes. Generally, smaller tumors had higher absolute drug concentration. In the hypothetical tumor, with volume less than 0.2 cm{sup 3}, the average drug concentration was 20% higher in comparison to its counterparts. For the various real tumor geometries, however, the maximum difference between average drug concentrations was 10% for the smallest and largest tumors. Moreover, the results demonstrated that for pancreatic tumors the shape is not significant. The negligible difference of drug concentration in different tumor shapes was due to the minimum effect of convection in pancreatic tumors. Conclusion: In tumors with different sizes, smaller tumors have higher drug delivery; however, the impact of tumor shape in the case of pancreatic

  17. Cybersecurity for Energy Delivery Systems (CEDS) Peer Review August 5-7

    Energy.gov [DOE]

    The Office of Electricity Delivery and Energy Reliability (OE) will hold a peer review of its Cybersecurity for Energy Delivery Systems (CEDS) Program and a Roadmap Milestone Assessment Workshop on August 5-7, 2014 at the Hilton Crystal City in Arlington, VA. This event is open to the public and will bring together leaders from industry, National Laboratories, and academia to hear first-hand about forthcoming CEDS solutions, provide feedback to CEDS program managers, and network with experts.

  18. Chapter 7: Advancing Systems and Technologies to Produce Cleaner Fuels | Hydrogen Production and Delivery Technology Assessment

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Hydrogen Production and Delivery Chapter 7: Technology Assessments Introduction to the Technology/System Hydrogen Production and Delivery: Opportunities and Challenges Hydrogen and hydrogen-rich fuels such as natural gas and biogas can be used in fuel cells to provide power and heat cleanly and efficiently in a wide range of transportation, stationary, and portable-power applications. Widespread deployment of hydrogen and fuel cell technologies offers a broad range of benefits for the

  19. Cybersecurity for Energy Delivery Systems (CEDS) Contact Information: For More Information:

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    through the Department of Energy's (DOE) Office of Electricity Delivery and Energy Reliability (OE) research and development (R&D) program, which aims to enhance the reliability and resilience of the nation's energy infrastructure by reducing the risk of energy disruptions due to cyber-attacks. Carol Hawk Program Manager DOE OE R&D Jianhui Wang Principal Investigator Argonne National Laboratory  http://energy.gov/oe/technology- development/energy-delivery- systems-cybersecurity

  20. DOE Issues Funding Opportunity for Innovations to Increase Cybersecurity for Energy Delivery Systems

    Energy.gov [DOE]

    The Office of Electricity Delivery and Energy Reliability issued a new Funding Opportunity Announcement (FOA), Innovation for Increasing Cybersecurity for Energy Delivery Systems, on February 8. The announcement is seeking applications to conduct research, development and demonstrations leading to next generation tools and technologies that will become widely adopted to enhance and accelerate deployment of cybersecurity capabilities for the U.S energy infrastructure, including cyber secure integration of smart grid technologies.

  1. Microcalibrator system for chemical signature and reagent delivery...

    Office of Scientific and Technical Information (OSTI)

    Sandia-designed prototype chemical sensor systems are undergoing extended field testing ... Resource Type: Technical Report Research Org: Sandia National Laboratories Sponsoring Org: ...

  2. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    to support robust projects that meet industry needs. Presentations on Vulnerability and Instrusion Detection are below. PDF icon CEDS 2010 Peer Review - Control Systems ...

  3. Electrical swing adsorption gas storage and delivery system

    DOE Patents [OSTI]

    Judkins, R.R.; Burchell, T.D.

    1999-06-15

    Systems and methods for electrical swing natural gas adsorption are described. An apparatus includes a pressure vessel; an electrically conductive gas adsorptive material located within the pressure vessel; and an electric power supply electrically connected to said adsorptive material. The adsorptive material can be a carbon fiber composite molecular sieve (CFCMS). The systems and methods provide advantages in that both a high energy density and a high ratio of delivered to stored gas are provided. 5 figs.

  4. Electrical swing adsorption gas storage and delivery system

    DOE Patents [OSTI]

    Judkins, Roddie R.; Burchell, Timothy D.

    1999-01-01

    Systems and methods for electrical swing natural gas adsorption are described. An apparatus includes a pressure vessel; an electrically conductive gas adsorptive material located within the pressure vessel; and an electric power supply electrically connected to said adsorptive material. The adsorptive material can be a carbon fiber composite molecular sieve (CFCMS). The systems and methods provide advantages in that both a high energy density and a high ratio of delivered to stored gas are provided.

  5. Alveolar targeting of aerosol pentamidine. Toward a rational delivery system

    SciTech Connect (OSTI)

    Simonds, A.K.; Newman, S.P.; Johnson, M.A.; Talaee, N.; Lee, C.A.; Clarke, S.W. )

    1990-04-01

    Nebulizer systems that deposit a high proportion of aerosolized pentamidine on large airways are likely to be associated with marked adverse side effects, which may lead to premature cessation of treatment. We have measured alveolar deposition and large airway-related side effects (e.g., cough, breathlessness, and effect on pulmonary function) after aerosolization of 150 mg pentamidine isethionate labeled with {sup 99m}Tc-Sn-colloid. Nine patients with AIDS were studied using three nebulizer systems producing different droplet size profiles: the Acorn System 22, Respirgard II, and Respirgard II with the inspiratory baffle removed. Alveolar deposition was greatest and side effects least with the nebulizer producing the smallest droplet size profile (Respirgard II), whereas large airway-related side effects were prominent and alveolar deposition lowest with the nebulizer producing the largest droplet size (Acorn System 22). Values for alveolar deposition and adverse airway effects were intermediate using the Respirgard with inspiratory baffle removed, thus indicating the importance of the baffle valve in determining droplet size. Addition of a similar baffle valve to the Acorn System 22 produced a marked improvement in droplet size profile. Selection of a nebulizer that produces an optimal droplet size range offers the advantage of enhancing alveolar targeting of aerosolized pentamidine while reducing large airway-related side effects.

  6. System and method for delivery of neutron beams for medical therapy

    DOE Patents [OSTI]

    Nigg, David W. (Idaho Falls, ID); Wemple, Charles A. (Idaho Falls, ID)

    1999-01-01

    A neutron delivery system that provides improved capability for tumor control during medical therapy. The system creates a unique neutron beam that has a bimodal or multi-modal energy spectrum. This unique neutron beam can be used for fast-neutron therapy, boron neutron capture therapy (BNCT), or both. The invention includes both an apparatus and a method for accomplishing the purposes of the invention.

  7. System and method for delivery of neutron beams for medical therapy

    DOE Patents [OSTI]

    Nigg, D.W.; Wemple, C.A.

    1999-07-06

    A neutron delivery system that provides improved capability for tumor control during medical therapy is disclosed. The system creates a unique neutron beam that has a bimodal or multi-modal energy spectrum. This unique neutron beam can be used for fast-neutron therapy, boron neutron capture therapy (BNCT), or both. The invention includes both an apparatus and a method for accomplishing the purposes of the invention. 5 figs.

  8. Systems and methods for bi-directional energy delivery with galvanic isolation

    DOE Patents [OSTI]

    Kajouke, Lateef A.

    2013-06-18

    Systems and methods are provided for bi-directional energy delivery. A charging system comprises a first bi-directional conversion module, a second bi-directional conversion module, and an isolation module coupled between the first bi-directional conversion module and the second bi-directional conversion module. The isolation module provides galvanic isolation between the first bi-directional conversion module and the second bi-directional conversion module.

  9. A "Plug-n-Play" Air Delivery System for Low-Load Homes and Evaluation of a

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Residential Thermal Comfort Rating Method | Department of Energy A "Plug-n-Play" Air Delivery System for Low-Load Homes and Evaluation of a Residential Thermal Comfort Rating Method A "Plug-n-Play" Air Delivery System for Low-Load Homes and Evaluation of a Residential Thermal Comfort Rating Method Traditional air distribution system. Graphic courtesy of IBACOS, Inc. Traditional air distribution system. Graphic courtesy of IBACOS, Inc. "Plug-n-Play" air delivery

  10. A Feasibility Study. Ductless Hydronic Distribution Systems with Fan Coil Delivery

    SciTech Connect (OSTI)

    Springer, D.; Dakin, B.; Backman, C.

    2012-07-01

    The primary objectives of this study are to estimate potential energy savings relative to conventional ducted air distribution, and to identify equipment requirements, costs, and barriers with a focus on ductless hydronic delivery systems that utilize water-to-air terminal units in each zone. Results indicate that annual heating and cooling energy use can be reduced by up to 27% assuming replacement of the conventional 13 SEER heat pump and coil with a similarly rated air-to-water heat pump.

  11. The CNAO dose delivery system for modulated scanning ion beam radiotherapy

    SciTech Connect (OSTI)

    Giordanengo, S.; Marchetto, F.; Garella, M. A.; Donetti, M.; Bourhaleb, F.; Monaco, V.; Hosseini, M. A.; Peroni, C.; Sacchi, R.; Cirio, R.; Ciocca, M.; Mirandola, A.

    2015-01-15

    Purpose: This paper describes the system for the dose delivery currently used at the Centro Nazionale di Adroterapia Oncologica (CNAO) for ion beam modulated scanning radiotherapy. Methods: CNAO Foundation, Istituto Nazionale di Fisica Nucleare and University of Torino have designed, built, and commissioned a dose delivery system (DDS) to monitor and guide ion beams accelerated by a dedicated synchrotron and to distribute the dose with a full 3D scanning technique. Protons and carbon ions are provided for a wide range of energies in order to cover a sizable span of treatment depths. The target volume, segmented in several layers orthogonally to the beam direction, is irradiated by thousands of pencil beams which must be steered and held to the prescribed positions until the prescribed number of particles has been delivered. For the CNAO beam lines, these operations are performed by the DDS. The main components of this system are two independent beam monitoring detectors, called BOX1 and BOX2, interfaced with two control systems performing the tasks of real-time fast and slow control, and connected to the scanning magnets and the beam chopper. As a reaction to any condition leading to a potential hazard, a DDS interlock signal is sent to the patient interlock system which immediately stops the irradiation. The essential tasks and operations performed by the DDS are described following the data flow from the treatment planning system through the end of the treatment delivery. Results: The ability of the DDS to guarantee a safe and accurate treatment was validated during the commissioning phase by means of checks of the charge collection efficiency, gain uniformity of the chambers, and 2D dose distribution homogeneity and stability. A high level of reliability and robustness has been proven by three years of system activity needing rarely more than regular maintenance and working with 100% uptime. Four identical and independent DDS devices have been tested showing

  12. Source and Extraction for Simultaneous Four-hall Beam Delivery System at CEBAF

    SciTech Connect (OSTI)

    Kazimi, Reza; Wang, Haipeng; Spata, Mike F.; Hansknecht, John C.

    2013-06-01

    A new design for simultaneous delivery of the electron beam to all four 12 GeV CEBAF experimental halls* requires a new 750 MHz RF separator system in the 5th pass extraction region, a 250 MHz repetition rate for its beams, and addition of a fourth laser at the photo-cathode gun. The proposed system works in tandem with the existing 500 MHz RF separators and beam repetition rate on the lower passes. The new 5th pass RF separators will have the same basic design but modified to run at 750 MHz. The change to the beam repetition rate will be at the photo-cathode gun through an innovative upgrade of the seed laser driver system using electro-optic modulators. The new laser system also allows addition of the fourth laser. The new RF separators, the new laser system and other hardware changes required to implement the Four-Hall operation delivery system will be discussed in this paper.

  13. Hydrothermal synthesis and afterglow luminescence properties of hollow SnO{sub 2}:Sm{sup 3+},Zr{sup 4+} spheres for potential application in drug delivery

    SciTech Connect (OSTI)

    Feng, Pengfei; Zhang, Jiachi Qin, Qingsong; Hu, Rui; Wang, Yuhua

    2014-02-01

    Highlights: We designed a novel afterglow labeling material SnO{sub 2}:Sm{sup 3+},Zr{sup 4+} for the first time. Hollow SnO{sub 2}:Sm{sup 3+},Zr{sup 4+} spheres with afterglow were prepared by hydrothermal method. Hollow SnO{sub 2}:Sm{sup 3+},Zr{sup 4+} is a potential afterglow labeling medium for drug delivery. - Abstract: A novel afterglow labeling material SnO{sub 2}:Sm{sup 3+},Zr{sup 4+} with hollow sphere shape and intense afterglow luminescence is prepared by hydrothermal method at 180 C for the first time. The morphology and the sphere growth process of this material are investigated by scanning electron microscopy in detail. The afterglow measurement shows that this hydrothermal obtained material exhibits obvious red afterglow luminescence (550700 nm) of Sm{sup 3+} which can last for 542 s (0.32 mcd/m{sup 2}). The depth of traps in this hydrothermal obtained material is calculated to be as shallow as 0.58 eV. The results demonstrate that although it is necessary to further improve the afterglow performance of the hydrothermal derived hollow SnO{sub 2}:Sm{sup 3+},Zr{sup 4+} spheres, it still can be regarded as a potential afterglow labeling medium for drug delivery.

  14. Energy-Sector Stakeholders Attend the Department of Energy’s Cybersecurity for Energy Delivery Systems Peer Review

    Energy.gov [DOE]

    The Department of Energy conducted a Peer Review of its Cybersecurity for Energy Delivery Systems (CEDS) Research and Development Program on July 20-22, during which 28 R&D projects were...

  15. Energy-Sector Stakeholders Attend the Department of Energy’s 2010 Cybersecurity for Energy Delivery Systems Peer Review

    Energy.gov [DOE]

    The Department of Energy conducted a Peer Review of its Cybersecurity for Energy Delivery Systems (CEDS) Research and Development Program on July 20-22, 2010 during which 28 R&D projects were...

  16. Soil chemical sensor and precision agricultural chemical delivery system and method

    DOE Patents [OSTI]

    Colburn, Jr., John W.

    1991-01-01

    A real time soil chemical sensor and precision agricultural chemical delivery system includes a plurality of ground-engaging tools in association with individual soil sensors which measure soil chemical levels. The system includes the addition of a solvent which rapidly saturates the soil/tool interface to form a conductive solution of chemicals leached from the soil. A multivalent electrode, positioned within a multivalent frame of the ground-engaging tool, applies a voltage or impresses a current between the electrode and the tool frame. A real-time soil chemical sensor and controller senses the electrochemical reaction resulting from the application of the voltage or current to the leachate, measures it by resistivity methods, and compares it against pre-set resistivity levels for substances leached by the solvent. Still greater precision is obtained by calibrating for the secondary current impressed through solvent-less soil. The appropriate concentration is then found and the servo-controlled delivery system applies the appropriate amount of fertilizer or agricultural chemicals substantially in the location from which the soil measurement was taken.

  17. Soil chemical sensor and precision agricultural chemical delivery system and method

    DOE Patents [OSTI]

    Colburn, J.W. Jr.

    1991-07-23

    A real time soil chemical sensor and precision agricultural chemical delivery system includes a plurality of ground-engaging tools in association with individual soil sensors which measure soil chemical levels. The system includes the addition of a solvent which rapidly saturates the soil/tool interface to form a conductive solution of chemicals leached from the soil. A multivalent electrode, positioned within a multivalent frame of the ground-engaging tool, applies a voltage or impresses a current between the electrode and the tool frame. A real-time soil chemical sensor and controller senses the electrochemical reaction resulting from the application of the voltage or current to the leachate, measures it by resistivity methods, and compares it against pre-set resistivity levels for substances leached by the solvent. Still greater precision is obtained by calibrating for the secondary current impressed through solvent-less soil. The appropriate concentration is then found and the servo-controlled delivery system applies the appropriate amount of fertilizer or agricultural chemicals substantially in the location from which the soil measurement was taken. 5 figures.

  18. Evaluation of aftermarket fuel delivery systems for natural gas and LPG vehicles

    SciTech Connect (OSTI)

    Willson, B. )

    1992-09-01

    This study was designed to evaluate the effectiveness of aftermarket fuel delivery systems for vehicles fueled by compressed natural gas (CNG) and liquefied petroleum gas (LPG). Most of the CNG and LPG vehicles studied were converted to the alternative fuel after purchase. There are wide variations in the quality of the conversion hardware and the installation. This leads to questions about the overall quality of the converted vehicles, in terms of emissions, safety, and performance. There is a considerable body of emissions data for converted light-duty vehicles, and a smaller amount for medium- and heavy-duty vehicles. However, very few of these data involve real world conditions, and there is growing concern about in-use emissions. This report also attempts to assess factors that could allow in-use emissions to vary from the best-case'' results normally reported. The study also addresses issues of fuel supply, fuel composition, performance, safety, and warranty waivers. The report is based on an extensive literature and product survey and on the author's experience with fuel delivery systems for light-duty vehicles.

  19. Evaluation of aftermarket fuel delivery systems for natural gas and LPG vehicles

    SciTech Connect (OSTI)

    Willson, B.

    1992-09-01

    This study was designed to evaluate the effectiveness of aftermarket fuel delivery systems for vehicles fueled by compressed natural gas (CNG) and liquefied petroleum gas (LPG). Most of the CNG and LPG vehicles studied were converted to the alternative fuel after purchase. There are wide variations in the quality of the conversion hardware and the installation. This leads to questions about the overall quality of the converted vehicles, in terms of emissions, safety, and performance. There is a considerable body of emissions data for converted light-duty vehicles, and a smaller amount for medium- and heavy-duty vehicles. However, very few of these data involve real world conditions, and there is growing concern about in-use emissions. This report also attempts to assess factors that could allow in-use emissions to vary from the ``best-case`` results normally reported. The study also addresses issues of fuel supply, fuel composition, performance, safety, and warranty waivers. The report is based on an extensive literature and product survey and on the author`s experience with fuel delivery systems for light-duty vehicles.

  20. Hydrogen Delivery Analysis Models

    Energy.gov [DOE]

    DOE H2A Delivery Models: Components Model (delivery system component costs and performance) and Scenario Model (for urban and rural/interstate markets and demand levels, market penetration)

  1. Tools and Methods for Hardening Communication Security of Energy Delivery Systems

    SciTech Connect (OSTI)

    Gadgil, Shrirang; Lin, Yow-Jian; Ghosh, Abhrajit; Samtani, Sunil; Kang, Jaewon; Siegell, Bruce; Kaul, Vikram; Unger, John; De Bruet, Andre; Martinez, Catherine; Vermeulen, Gerald; Rasche, Galen; Sternfeld, Scott; Berthier, Robin; Bobba, Rakesh; Campbell, Roy; Sanders, Williams; Lin, Yow-Jian

    2014-06-30

    This document summarizes the research and development work the TT Government Solutions (TTGS), d.b.a. Applied Communication Sciences (ACS), team performed for the Department of Energy Cybersecurity for Energy Delivery Systems (CEDS) program. It addresses the challenges in protecting critical grid control and data communication, including the identification of vulnerabilities and deficiencies of communication protocols commonly used in energy delivery systems (e.g., ICCP, DNP3, C37.118, C12.22), as well as the development of effective means to detect and prevent the exploitation of such vulnerabilities and deficiencies. The team consists of • TT Government Solutions (TTGS), a leading provider of communications solutions that has extensive experience in commercializing communications solutions. TTGS also has deep cyber security research and development expertise supporting a variety of customers. • University of Illinois at Urbana-Champaign (UIUC), a leader in the cyber security research for the power grid. UIUC brings unique experience in designing secure communication protocols to this project. • Electric Power Research Institute (EPRI), an independent nonprofit that conducts research and development relating to the generation, delivery and use of electricity for the benefit of the public. EPRI brings to this effort its extensive technical expertise and its utility connections, with members representing more than 90 percent of the electricity generated and delivered in the United States. • DTE Energy, the 10th largest electric utility in the US, which helps ensure that this project focuses on the needs of utilities and is rightly positioned to address the needs of the market place. We designed, developed, and demonstrated a modular and extensible ADEC-G (Agent-based, Distributed, Extensible Cybersecurity for the Grid) system for monitoring/detecting abnormal energy delivery systems (EDS) protocol usage and ensuring security coverage. Our approach consists

  2. Penetration of gas delivery systems in the United States: A state-level data analysis

    SciTech Connect (OSTI)

    Guldmann, J.M. . Environmental Assessment and Information Sciences Div. Ohio State Univ., Columbus, OH )

    1990-02-01

    The purpose of this study is to assess the degree to which the gas delivery infrastructure penetrates US regions and states and to pinpoint those areas in which the lack of a sufficient infrastructure impedes the expansion of the natural gas market. Regions and states are ranked according to several indicators developed with data published by the American Gas Association, the US Department of Energy/Energy Information Administration, and the US Bureau of the Census. These include the numbers of gas customers and gas deliveries by sector, mileages of distribution and transmission pipelines, underground storage capacities and operating characteristics, heating degree-days, populations and numbers of households, and areal measures of states and metropolitan areas. The market penetration of gas distribution systems is measured by two indicators: (1) the ratio of the number of residential gas customers to the number of households in 1985 and (2) the distribution pipeline density, measured by the ratio of the 1985 distribution mileage divided by the number of households, while accounting for the effect of urban population density (using earlier econometric results). 11 refs., 1 fig., 27 tabs.

  3. Hydrogen Delivery Analysis Models

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Models Amgad Elgowainy (ANL), Marianne Mintz (ANL), Jerry Gillette (ANL), Matt Ringer (NREL), Bruce Kelly (Nexant), Matt Hooks (TIAX), Daryl Brown (PNNL), and Mark Paster (DOE) September, 2007 DOE H2A Delivery Models Spreadsheet model for delivery system component costs and performance: Components Model Delivery scenario model for Urban and Rural /Interstate markets and demand levels (Mkt. Penetration) Scenario Model Estimates the cost of H 2 ($/kg) (and V2: energy and GHG) Assumes 2005 delivery

  4. NGNP Data Management and Analysis System Analysis and Web Delivery Capabilities

    SciTech Connect (OSTI)

    Cynthia D. Gentillon

    2011-09-01

    Projects for the Very High Temperature Reactor (VHTR) Technology Development Office provide data in support of Nuclear Regulatory Commission licensing of the very high temperature reactor. Fuel and materials to be used in the reactor are tested and characterized to quantify performance in high-temperature and high-fluence environments. The NGNP Data Management and Analysis System (NDMAS) at the Idaho National Laboratory has been established to ensure that VHTR data are (1) qualified for use, (2) stored in a readily accessible electronic form, and (3) analyzed to extract useful results. This document focuses on the third NDMAS objective. It describes capabilities for displaying the data in meaningful ways and for data analysis to identify useful relationships among the measured quantities. The capabilities are described from the perspective of NDMAS users, starting with those who just view experimental data and analytical results on the INL NDMAS web portal. Web display and delivery capabilities are described in detail. Also the current web pages that show Advanced Gas Reactor, Advanced Graphite Capsule, and High Temperature Materials test results are itemized. Capabilities available to NDMAS developers are more extensive, and are described using a second series of examples. Much of the data analysis efforts focus on understanding how thermocouple measurements relate to simulated temperatures and other experimental parameters. Statistical control charts and correlation monitoring provide an ongoing assessment of instrument accuracy. Data analysis capabilities are virtually unlimited for those who use the NDMAS web data download capabilities and the analysis software of their choice. Overall, the NDMAS provides convenient data analysis and web delivery capabilities for studying a very large and rapidly increasing database of well-documented, pedigreed data.

  5. Waste Feed Delivery System Phase 1 Preliminary Reliability and Availability and Maintainability Analysis [SEC 1 and 2

    SciTech Connect (OSTI)

    CARLSON, A.B.

    1999-11-11

    The document presents updated results of the preliminary reliability, availability, maintainability analysis performed for delivery of waste feed from tanks 241-AZ-101 and 241-AN-105 to British Nuclear Fuels Limited, inc. under the Tank Waste Remediation System Privatization Contract. The operational schedule delay risk is estimated and contributing factors are discussed.

  6. SU-E-T-107: Development of a GPU-Based Dose Delivery System for Adaptive Pencil Beam Scanning

    SciTech Connect (OSTI)

    Giordanengo, S; Russo, G; Marchetto, F; Attili, A; Monaco, V; Varasteh, M; Pella, A

    2014-06-01

    Purpose: A description of a GPU-based dose delivery system (G-DDS) to integrate a fast forward planning implementing in real-time the prescribed sequence of pencil beams. The system, which is under development, is designed to evaluate the dose distribution deviations due to range variations and interplay effects affecting mobile tumors treatments. Methods: The Dose Delivery System (DDS) in use at the Italian Centro Nazionale di Adroterapia Oncologica (CNAO), is the starting point for the presented system. A fast and partial forward planning (FP) tool has been developed to evaluate in few seconds the delivered dose distributions using the DDS data (on-line measurements of spot properties, i.e. number of particles and positions). The computation is performed during the intervals between synchrotron spills and, made available at the end of each spill. In the interval between two spills, the G-DDS will evaluate the delivered dose distributions taking into account the real-time target positions measured by a tracking system. The sequence of prescribed pencil beams for the following spill will be adapted taking into account the variations with respect to the original plan due to the target motion. In order to speed up the computation required to modify pencil beams distribution (up to 400 times has been reached), the Graphics Processing Units (GPUs) and advanced Field Programmable Gate Arrays (FPGAs) are used. Results: An existing offline forward planning is going to be optimized for the CUDA architecture: the gain in time will be presented. The preliminary performances of the developed GPU-based FP algorithms will be shown. Conclusion: A prototype of a GPU-based dose delivery system is under development and will be presented. The system workflow will be illustrated together with the approach adopted to integrate the three main systems, i.e. CNAO dose delivery system, fast forward planning, and tumor tracking system.

  7. SU-E-T-442: Sensitivity of Quality Assurance Tools to Delivery Errors On a Magnetic Resonance-Imaging Guided Radiation Therapy (MR-IGRT) System

    SciTech Connect (OSTI)

    Rodriguez, V; Li, H; Yang, D; Kashani, R; Wooten, H; Mutic, S; Green, O; Dempsey, J

    2014-06-01

    Purpose: To test the sensitivity of the quality assurance (QA) tools actively used on a clinical MR-IGRT system for potential delivery errors. Methods: Patient-specific QA procedures have been implemented for a commercially available Cobalt-60 MR-IGRT system. The QA tools utilized were a MR-compatible cylindrical diode-array detector (ArcCHECK) with a custom insert which positions an ionization chamber (Exradin A18) in the middle of the device, as well as an in-house treatment delivery verification program. These tools were tested to investigate their sensitivity to delivery errors. For the ArcCHECK and ion chamber, a baseline was established with a static field irradiation to a known dose. Variations of the baseline were investigated which included rotated gantry, altered field size, directional shifts, and different delivery time. In addition, similar variations were tested with the automated delivery verification program that compared the treatment parameters in the machine delivery logs to the ones in the plan. To test the software, a 3-field conformal plan was generated as the baseline. Results: ArcCHECK noted at least a 13% decrease in passing rate from baseline in the following scenarios: gantry rotation of 1 degree from plan, 5mm change in field size, 2mm lateral shift, and delivery time decrease. Ion chamber measurements remained consistent for these variations except for the 5 second decrease in delivery time scenario which resulted in an 8% difference from baseline. The delivery verification software was able to detect and report the simulated errors such as when the gantry was rotated by 0.6 degrees, the beam weighting was changed by a percent, a single multileaf collimator was moved by 1cm, and the dose was changed from 2 to 1.8Gy. Conclusion: The results show that the current tools used for patient specific QA are capable of detecting small errors in RT delivery with presence of magnetic field.

  8. A simple, rapid, and sensitive system for the evaluation of anti-viral drugs in rats

    SciTech Connect (OSTI)

    Li, Xiaoguang; Qian, Hua; Miyamoto, Fusako; Kawaji, Kumi; Hattori, Toshio; Watanabe, Kentaro; Oishi, Shinya; Fujii, Nobutaka; and others

    2012-07-27

    Highlights: Black-Right-Pointing-Pointer We established a novel, simple and rapid in vivo system for evaluation of anti-HIV-1 drugs with rats. Black-Right-Pointing-Pointer The system may be applicable for other antiviral drugs, and/or useful for initial screening in vivo. Black-Right-Pointing-Pointer In this system, TRI-1144 displayed the most potent anti-HIV-1 activity in vivo. -- Abstract: The lack of small animal models for the evaluation of anti-human immunodeficiency virus type 1 (HIV-1) agents hampers drug development. Here, we describe the establishment of a simple and rapid evaluation system in a rat model without animal infection facilities. After intraperitoneal administration of test drugs to rats, antiviral activity in the sera was examined by the MAGI assay. Recently developed inhibitors for HIV-1 entry, two CXCR4 antagonists, TF14016 and FC131, and four fusion inhibitors, T-20, T-20EK, SC29EK, and TRI-1144, were evaluated using HIV-1{sub IIIB} and HIV-1{sub BaL} as representative CXCR4- and CCR5-tropic HIV-1 strains, respectively. CXCR4 antagonists were shown to only possess anti-HIV-1{sub IIIB} activity, whereas fusion inhibitors showed both anti-HIV-1{sub IIIB} and anti-HIV-1{sub BaL} activities in rat sera. These results indicate that test drugs were successfully processed into the rat sera and could be detected by the MAGI assay. In this system, TRI-1144 showed the most potent and sustained antiviral activity. Sera from animals not administered drugs showed substantial anti-HIV-1 activity, indicating that relatively high dose or activity of the test drugs might be needed. In conclusion, the novel rat system established here, 'phenotypic drug evaluation', may be applicable for the evaluation of various antiviral drugs in vivo.

  9. Lubricating system for thermal medium delivery parts in a gas turbine

    DOE Patents [OSTI]

    Mashey, Thomas Charles (Coxsackie, NY)

    2002-01-01

    Cooling steam delivery tubes extend axially along the outer rim of a gas turbine rotor for supplying cooling steam to and returning spent cooling steam from the turbine buckets. Because of the high friction forces at the interface of the tubes and supporting elements due to rotor rotation, a low coefficient of friction coating is provided at the interface of the tubes and support elements. On each surface, a first coating of a cobalt-based alloy is sprayed onto the surface at high temperature. A portion of the first coating is machined off to provide a smooth, hard surface. A second ceramic-based solid film lubricant is sprayed onto the first coating. By reducing the resistance to axial displacement of the tubes relative to the supporting elements due to thermal expansion, the service life of the tubes is substantially extended.

  10. System Description for the K-25/K-27 D&D Project Polyurethane Foam Delivery System, East Tennessee Technology Park, Oak Ridge, Tennessee

    SciTech Connect (OSTI)

    Boris, G.

    2008-02-21

    The Foam Delivery System used in the decontamination and decommissioning (D&D) project for the K-25/K-27 Buildings at the East Tennessee Technology Park (ETTP) is comprised of a trailer-mounted Gusmer{reg_sign} H20/35 Pro-TEC Proportioning Unit and the associated equipment to convey electrical power, air, and foam component material to the unit. This high-pressure, plural-component polyurethane foam pouring system will be used to fill process gas and non-process equipment/piping (PGE/P) within the K-25/K-27 Buildings with polyurethane foam to immobilize contaminants prior to removal. The system creates foam by mixing isocyanate and polyol resin (Resin) component materials. Currently, the project plans to utilize up to six foaming units simultaneously during peak foaming activities. Also included in this system description are the foam component material storage containers that will be used for storage of the component material drums in a staging area outside of the K-25/K-27 Buildings. The Foam Delivery System and foam component material storage enclosures (i.e., Foaming Component Protective Enclosures) used to store polymeric methylene diphenyl diisocyanate (PMDI) component material are identified as Safety Significant (SS) Structures, Systems and Components (SSC) in the Documented Safety Analysis (DSA) for the project, Documented Safety Analysis for the K-25 and K-27 Facilities at the East Tennessee Technology Park, Oak Ridge, Tennessee, DSA-ET-K-25/K-27-0001.

  11. Safe and compact ammonia storage/delivery systems for SCR-DeNOX...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Safe and compact ammonia storagedelivery systems for SCR-DeNOX in automotive units Safe and compact ammonia storagedelivery systems for SCR-DeNOX in automotive units Presentation ...

  12. Document Delivery

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Services » Document Delivery Document Delivery The Research Library can order journal articles, conference papers and book chapters not found in the Library collection for LANL staff. The service is provided by our vendor, Reprints Desk, who will mail the article to you as a PDF. Easily retrieved articles may be delivered the same day, while harder-to-find material can take several days/weeks. This service is limited to LANL employees with active Z numbers. Requesting Materials Use the Request

  13. A survey of commercially available manipulators, end-effectors, and delivery systems for reactor decommissioning activities

    SciTech Connect (OSTI)

    Henley, D.R.; Litka, T.J.

    1996-05-01

    Numerous nuclear facilities owned by the U.S. Department of Energy (DOE) are under consideration for decommissioning. Currently, there are no standardized, automated, remote systems designed to dismantle and thereby reduce the size of activated reactor components and vessels so that they can be packaged and shipped to disposal sites. Existing dismantling systems usually consist of customized, facility-specific tooling that has been developed to dismantle a specific reactor system. Such systems have a number of drawbacks. Generally, current systems cannot be disassembled, moved, and reused. Developing and deploying the tooling for current systems is expensive and time-consuming. In addition, the amount of manual work is significant because long-handled tools must be used; as a result, personnel are exposed to excessive radiation. A standardized, automated, remote system is therefore needed to deliver the tooling necessary to dismantle nuclear facilities at different locations. Because this system would be reusable, it would produce less waste. The system would also save money because of its universal design, and it would be more reliable than current systems.

  14. Solar concentrator with integrated tracking and light delivery system with summation

    DOE Patents [OSTI]

    Maxey, Lonnie Curt

    2015-05-05

    A solar light distribution system includes a solar light concentrator that is affixed externally to a light transfer tube. Solar light waves are processed by the concentrator into a collimated beam of light, which is then transferred through a light receiving port and into the light transfer tube. A reflector redirects the collimated beam of light through the tube to a light distribution port. The interior surface of the light transfer tube is highly reflective so that the light transfers through the tube with minimal losses. An interchangeable luminaire is attached to the light distribution port and provides light inside of a structure. A sun tracking device rotates the concentrator and the light transfer tube to optimize the receiving of solar light by the concentrator throughout the day. The system provides interior lighting that uses only renewable energy sources, and releases no carbon dioxide emissions into the atmosphere.

  15. Solar concentrator with integrated tracking and light delivery system with collimation

    DOE Patents [OSTI]

    Maxey, Lonnie Curt

    2015-06-09

    A solar light distribution system includes a solar light concentrator that is affixed externally to a light transfer tube. Solar light waves are processed by the concentrator into a collimated beam of light, which is then transferred through a light receiving port and into the light transfer tube. A reflector directs the collimated beam of light through the tube to a light distribution port. The interior surface of the light transfer tube is highly reflective so that the light transfers through the tube with minimal losses. An interchangeable luminaire is attached to the light distribution port and distributes light inside of a structure. A sun tracking device rotates the concentrator and the light transfer tube to optimize the receiving of solar light by the concentrator throughout the day. The system provides interior lighting, uses only renewable energy sources, and releases no carbon dioxide emissions into the atmosphere.

  16. One System Integrated Project Team: Retrieval and Delivery of Hanford Tank Wastes for Vitrification in the Waste Treatment Plant - 13234

    SciTech Connect (OSTI)

    Harp, Benton J.; Kacich, Richard M.; Skwarek, Raymond J.

    2013-07-01

    The One System Integrated Project Team (IPT) was formed in late 2011 as a way for improving the efficiency of delivery and treatment of highly radioactive waste stored in underground tanks at the U.S. Department of Energy's (DOE's) 586-square-mile Hanford Site in southeastern Washington State. The purpose of the One System IPT is to improve coordination and integration between the Hanford's Waste Treatment Plant (WTP) contractor and the Tank Operations Contractor (TOC). The vision statement is: One System is a WTP and TOC safety-conscious team that, through integrated management and implementation of risk-informed decision and mission-based solutions, will enable the earliest start of safe and efficient treatment of Hanford's tank waste, to protect the Columbia River, environment and public. The IPT is a formal collaboration between Bechtel National, Inc. (BNI), which manages design and construction of the WTP for the U.S. Department of Energy's Office of River Protection (DOEORP), and Washington River Protection Solutions (WRPS), which manages the TOC for ORP. More than fifty-six (56) million gallons of highly radioactive liquid waste are stored in one hundred seventy-seven (177) aging, underground tanks. Most of Hanford's waste tanks - one hundred forty-nine (149) of them - are of an old single-shell tank (SST) design built between 1944 and 1964. More than sixty (60) of these tanks have leaked in the past, releasing an estimated one million gallons of waste into the soil and threatening the nearby Columbia River. There are another twenty-eight (28) new double-shelled tanks (DSTs), built from 1968 to 1986, that provide greater protection to the environment. In 1989, DOE, the U.S. Environmental Protection Agency (EPA), and the Washington State Department of Ecology (Ecology) signed a landmark agreement that required Hanford to comply with federal and state environmental standards. It also paved the way for agreements that set deadlines for retrieving the tank

  17. One System Integrated Project Team: Retrieval And Delivery Of The Hanford Tank Wastes For Vitrification In The Waste Treatment Plant

    SciTech Connect (OSTI)

    Harp, Benton J.; Kacich, Richard M.; Skwarek, Raymond J.

    2012-12-20

    The One System Integrated Project Team (IPT) was formed in late 2011 as a way for improving the efficiency of delivery and treatment of highly radioactive waste stored in underground tanks at the U.S. Department of Energy's (DOE's) 586-square-mile Hanford Site in southeastern Washington State. The purpose of the One System IPT is to improve coordination and integration between the Hanford's Waste Treatment Plant (WTP) contractor and the Tank Operations Contractor (TOC). The vision statement is: One System is a WTP and TOC safety conscious team that, through integrated management and implementation of risk-informed decision and mission-based solutions, will enable the earliest start of safe and efficient treatment of Hanford's tank waste, to protect the Columbia River, environment and public. The IPT is a formal collaboration between Bechtel National, Inc. (BNI), which manages design and construction of the WTP for the U.S. Department of Energy's Office of River Protection (DOEORP), and Washington River Protection Solutions (WRPS), which manages the TOC for ORP. More than fifty-six (56) million gallons of highly radioactive liquid waste are stored in one hundred seventy-seven (177) aging, underground tanks. Most of Hanford's waste tanks - one hundred forty-nine (149) of them - are of an old single-shell tank (SST) design built between 1944 and 1964. More than sixty (60) of these tanks have leaked in the past, releasing an estimated one million gallons of waste into the soil and threatening the nearby Columbia River. There are another twenty-eight (28) new double-shelled tanks (DSTs), built from 1968 to 1986, that provide greater protection to the environment. In 1989, DOE, the U.S. Environmental Protection Agency (EPA), and the Washington State Department of Ecology (Ecology) signed a landmark agreement that required Hanford to comply with federal and state environmental standards. It also paved the way for agreements that set deadlines for retrieving the tank

  18. NGNP Data Management and Analysis System Analysis and Web Delivery Capabilities

    SciTech Connect (OSTI)

    Cynthia D. Gentillon

    2010-09-01

    Projects for the Very High Temperature Reactor Technology Development Office provide data in support of Nuclear Regulatory Commission licensing of the very high temperature reactor. Fuel and materials to be used in the reactor are tested and characterized to quantify performance in high-temperature and high-fluence environments. In addition, thermal-hydraulic experiments are conducted to validate codes used to assess reactor safety. The Very High Temperature Reactor Technology Development Office has established the NGNP Data Management and Analysis System (NDMAS) at the Idaho National Laboratory to ensure that very high temperature reactor data are (1) qualified for use, (2) stored in a readily accessible electronic form, and (3) analyzed to extract useful results. This document focuses on the third NDMAS objective. It describes capabilities for displaying the data in meaningful ways and for data analysis to identify useful relationships among the measured quantities.

  19. Multi-point injection: A general purpose delivery system for treatment and containment of hazardous and radiological waste

    SciTech Connect (OSTI)

    Kauschinger, J.L.; Kubarewicz, J.; Van Hoesen, S.D.

    1997-12-31

    The multi-point injection (MPI) technology is a proprietary jetting process for the in situ delivery of various agents to treat radiological and/or chemical wastes. A wide variety of waste forms can be treated, varying from heterogeneous solid waste dumped into shallow burial trenches, bottom sludge (heel material) inside of underground tanks, and contaminated soils with widely varying soil composition (gravel, silts/clays, soft rock). The robustness of the MPI system is linked to the use of high speed mono-directional jets to deliver various types of agents for a variety of applications, such as: pretreatment of waste prior to insitu vitrification, solidification of waste for creating low conductivity monoliths, oxidants for insitu destruction of organic waste, and grouts for creating barriers (vertical, inclined, and bottom seals). The only strict limitation placed upon the MPI process is that the material can be pumped under high pressure. This paper describes the procedures to inject ordinary grout to form solidified monoliths of solid wastes.

  20. X-Band Crab Cavities for the CLIC Beam Delivery System

    SciTech Connect (OSTI)

    Burt, G.; Ambattu, P.K.; Dexter, A.C.; Abram, T.; Dolgashev, V.; Tantawi, S.; Jones, R.M.; /Cockcroft Inst. Accel. Sci. Tech. /Manchester U.

    2011-11-22

    The CLIC machine incorporates a 20 mrad crossing angle at the IP to aid the extraction of spent beams. In order to recover the luminosity lost through the crossing angle a crab cavity is proposed to rotate the bunches prior to collision. The crab cavity is chosen to have the same frequency as the main linac (11.9942 GHz) as a compromise between size, phase stability requirements and beam loading. It is proposed to use a HE11 mode travelling wave structure as the CLIC crab cavity in order to minimise beam loading and mode separation. The position of the crab cavity close to the final focus enhances the effect of transverse wake-fields so effective wake-field damping is required. A damped detuned structure is proposed to suppress and de-cohere the wake-field hence reducing their effect. Design considerations for the CLIC crab cavity will be discussed as well as the proposed high power testing of these structures at SLAC. Design of a crab cavity for CLIC is underway at the Cockcroft Institute in collaboration with SLAC. This effort draws on a large degree of synergy with the ILC crab cavity developed at the Cockcroft Institute and other deflecting structure development at SLAC. A study of phase and amplitude variations in the cavity suggests that the tolerances are very tight and require a 'beyond state of the art' LLRF control system. A study of cavity geometry and its effect on the cavity fields has been performed using Microwave studio. This study has suggested that for our cavity an iris radius between 4-5 mm is optimum with an iris thickness of 2-3 mm based on group velocity and peak fields. A study of the cavity wakefields show that the single bunch wakes are unlikely to be a problem but the short bunch spacing may cause the multi-bunch wakefields to be an issue. This will require some of the modes to be damped strongly so that the wake is damped significantly before any following bunch arrives. Various methods of damping have been investigated and suggest that

  1. SU-E-T-407: Evaluation of Four Commercial Dosimetry Systems for Routine Patient-Specific Tomotherapy Delivery Quality Assurance

    SciTech Connect (OSTI)

    Xing, A; Arumugam, S; Deshpande, S; George, A; Holloway, L; Vial, P; Goozee, G

    2014-06-01

    Purpose: The purpose of this project was to evaluate the performance of four commercially available dosimetry systems for Tomotherapy delivery quality assurance (DQA). Methods: Eight clinical patient plans were chosen to represent a range of treatment sites and typical clinical plans. Four DQA plans for each patient plan were created using the TomoTherapy DQA Station (Hi-Art version 4.2.1) on CT images of the ScandiDose Delta4, IBA MatriXX Evolution, PTW Octavius 4D and Sun Nuclear ArcCHECK phantoms. Each detector was calibrated following the manufacture-provided procedure. No angular response correction was applied. All DQA plans for each detector were delivered on the Tomotherapy Hi-Art unit in a single measurement session but on different days. The measured results were loaded into the vendor supplied software for each QA system for comparison with the TPS-calculated dose. The Gamma index was calculated using 3%/3mm, 2%/2mm with 10% dose threshold of maximum TPS calculated dose. Results: Four detector systems showed comparable gamma pass rates for 3%/3m, which is recommended by AAPM TG119 and commonly used within the radiotherapy community. The averaged pass rates standard deviation for all DQA plans were (98.351.97)% for ArcCHECK, (99.9%0.87)% for Matrix, (98.5%5.09)% for Octavius 4D, (98.7%1.27)% for Delata4. The rank of the gamma pass rate for individual plans was consistent between detectors. Using 2%/2mm Gamma criteria for analysis, the Gamma pass rate decreased on average by 9%, 8%, 6.6% and 5% respectively. Profile and Gamma failure map analysis using the software tools from each dosimetry system indicated that decreased passing rate is mainly due to the threading effect of Tomo plan. Conclusion: Despite the variation in detector type and resolution, phantom geometry and software implementation, the four systems demonstrated similar dosimetric performance, with the rank of the gamma pass rate consistent for the plans considered.

  2. Assessment of Available Particle Size Data to Support an Analysis of the Waste Feed Delivery System Transfer System

    SciTech Connect (OSTI)

    JEWETT, J.R.

    2000-08-10

    Available data pertaining to size distribution of the particulates in Hanford underground tank waste have been reviewed. Although considerable differences exist between measurement methods, it may be stated with 95% confidence that the median particle size does not exceed 275 {micro}m in at least 95% of the ten tanks selected as sources of HLW feed for Phase 1 vitrification in the RPP. This particle size is recommended as a design basis for the WFD transfer system.

  3. Novel Flow Sheet for Low Energy CO2 Capture Enabled by Biocatalyst Delivery System

    SciTech Connect (OSTI)

    Reardon, John; Shaffer, Alex; Vaysman, Vladimir

    2015-02-01

    This report documents a preliminary Techno-Economic Assessment (TEA) for processes utilizing Akermin’s second generation biocatalyst delivery system to enhance AKM24, a non- volatile salt solution for CO2 capture. Biocatalyst enhanced AKM24 offers the potential to reduce the cost of CO2 capture in flue gas applications due to its improved equilibrium and stoichiometric properties that result in double the absorption capacity relative to previously demonstrated biocatalyst enhanced solvents. The study assumes a new supercritical pulverized coal fired power plant with a net output of 550 MWe after 90% CO2 capture and uses the June 2011 cost basis (August 2012 update of Bituminous Baseline Study, or BBS). Power plant modeling, capital cost review, and economic calculations were provided by WorleyParsons. Rate-based CO2 capture process modeling and equipment sizing was performed by Akermin using AspenPlus® V8.4, customized to accurately predict thermodynamics, kinetics, and physical properties of the AKM-24 solvent based on available laboratory data. Equipment capital costs were estimated using Aspen Process Economic Analyzer™ which compared well with published baseline cost estimates. Quotes of equipment costs and power consumption for vacuum blower and CO2 compression equipment were also provided by Man Diesel & Turbo. Three process scenarios were examined for Akermin biocatalyst enhanced solvent systems including: Case-1A: an absorption-desorption system operated with a reboiler pressure of 0.16 bara (60°C); Case-2A: an absorption-desorption system with moderate vacuum assisted regeneration at 0.40 bara (80°C); and finally, Case-2B: a conventional absorption-desorption system with near atmospheric pressure regeneration at 1.07 bara (105°C). The estimated increases in cost of electricity (ICOE) for these cases were $58.1/MWh, $47.3/MWh and $46.4/MWh, respectively. Case 2B had the best results for this analysis

  4. Industry Partnerships for Cybersecurity of Energy Delivery Systems (CEDS) Research, Development and Demonstration for the Energy Sector Funding Opportunity Announcement

    Energy.gov [DOE]

    Modernizing our electric power grid has long been a key priority for the Department of Energy, and this month the Department is moving forward on that front with a series of announcements related to our ongoing Grid Modernization Initiative. As part of that effort, the Office of Electricity Delivery and Energy Reliability announced approximately $23 million in funding for the research and development of advanced cybersecurity technologies to meet the unique requirements of the energy sector.

  5. ELECTRICITY DELIVERY AND ENERGY RELIABILITY Appropriation Overview

    Energy.gov (indexed) [DOE]

    ... modernize the distribution portion of the electric delivery system. The program conducts R&D on microgrids and resilient ... edge cybersecurity solutions, information sharing to ...

  6. Drug Testing Notification | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Drug Testing Notification Drug Testing Notification PDF icon Drug Testing Notification More Documents & Publications Intergrated Drug Testing System, PIA, Bechtel Jacobs C ompany, ...

  7. Macro-System Model: A Federated Object Model for Cross-Cutting Analysis of Hydrogen Production, Delivery, Consumption and Associated Emissions; Preprint

    SciTech Connect (OSTI)

    Ruth, M.; Diakov, V.; Goldsby, M. E.; Sa, T. J.

    2010-12-01

    It is commonly accepted that the introduction of hydrogen as an energy carrier for light-duty vehicles involves concomitant technological development of infrastructure elements, such as production, delivery, and consumption, all associated with certain emission levels. To analyze these at a system level, the suite of corresponding models developed by the United States Department of Energy and involving several national laboratories is combined in one macro-system model (MSM). The macro-system model is being developed as a cross-cutting analysis tool that combines a set of hydrogen technology analysis models. Within the MSM, a federated simulation framework is used for consistent data transfer between the component models. The framework is built to suit cross-model as well as cross-platform data exchange and involves features of 'over-the-net' computation.

  8. Hydrogen delivery technology roadmap

    SciTech Connect (OSTI)

    None, None

    2005-11-15

    Document describing plan for research into and development of hydrogen delivery technology for transportation applications.

  9. About the Office of Electricity Delivery and Energy Reliability |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy the Office of Electricity Delivery and Energy Reliability About the Office of Electricity Delivery and Energy Reliability About the Office of Electricity Delivery and Energy Reliability The Office of Electricity Delivery and Energy Reliability (OE) provides national leadership to ensure that the Nation's energy delivery system is secure, resilient and reliable. OE works to develop new technologies to improve the infrastructure that brings electricity into our homes,

  10. LNG - Engine Delivery - Energy Innovation Portal

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Vehicles and Fuels Vehicles and Fuels Find More Like This Return to Search LNG - Engine Delivery Idaho National Laboratory Contact INL About This Technology Technology Marketing Summary This is a method of improved delivery of liquid natural gas (LNG) within an engine delivery system. The LNG is first pumped into the insulated holding tank from a fueling station. As a tank is refueled, any remaining natural gas vapors are condensed and returned to the liquid state. This allows the tank to fill

  11. Time-Resolved SAXS/WAXS Study of the Phase Behavior and Microstructural Evolution of Drug/PEG Solid Dispersions

    SciTech Connect (OSTI)

    Zhu, Qing; Harris, Michael T.; Taylor, Lynne S.

    2013-03-07

    Simultaneous small-angle X-ray scattering/wide-angle X-ray scattering (SAXS/WAXS) was employed to elucidate the physical state and location of various small molecule drugs blended with polyethylene glycol (PEG), as well as the time dependent microstructural evolution of the systems. Samples were prepared by comelting physical mixtures of the drug and PEG, followed by solidification at 25 C. The model drugs selected encompassed a wide variety of physicochemical properties in terms of crystallization tendency and potential for interaction with PEG. It was observed that compounds which crystallized rapidly and had weak interactions with PEG tended to be excluded from the interlamellar region of the PEG matrix. In contrast, drugs which had favorable interactions with PEG were incorporated into the interlamellar regions of the polymer up until the point at which the drug crystallized whereby phase separation occurred. These factors are likely to impact the effectiveness of drug/PEG systems as drug delivery systems.

  12. SU-E-T-586: Optimal Determination of Tolerance Level for Radiation Dose Delivery Verification in An in Vivo Dosimetry System

    SciTech Connect (OSTI)

    Chen, Y; Souri, S; Gill, G; Rea, A; Kuruvilla, A; Riegel, A; Cao, Y; Jamshidi, A

    2015-06-15

    Purpose: To statistically determine the optimal tolerance level in the verification of delivery dose compared to the planned dose in an in vivo dosimetry system in radiotherapy. Methods: The LANDAUER MicroSTARii dosimetry system with screened nanoDots (optically stimulated luminescence dosimeters) was used for in vivo dose measurements. Ideally, the measured dose should match with the planned dose and falls within a normal distribution. Any deviation from the normal distribution may be redeemed as a mismatch, therefore a potential sign of the dose misadministration. Randomly mis-positioned nanoDots can yield a continuum background distribution. A percentage difference of the measured dose to its corresponding planned dose (ΔD) can be used to analyze combined data sets for different patients. A model of a Gaussian plus a flat function was used to fit the ΔD distribution. Results: Total 434 nanoDot measurements for breast cancer patients were collected across a period of three months. The fit yields a Gaussian mean of 2.9% and a standard deviation (SD) of 5.3%. The observed shift of the mean from zero is attributed to the machine output bias and calibration of the dosimetry system. A pass interval of −2SD to +2SD was applied and a mismatch background was estimated to be 4.8%. With such a tolerance level, one can expect that 99.99% of patients should pass the verification and at most 0.011% might have a potential dose misadministration that may not be detected after 3 times of repeated measurements. After implementation, a number of new start breast cancer patients were monitored and the measured pass rate is consistent with the model prediction. Conclusion: It is feasible to implement an optimal tolerance level in order to maintain a low limit of potential dose misadministration while still to keep a relatively high pass rate in radiotherapy delivery verification.

  13. Self-assembled pentablock copolymers for selective and sustained gene delivery

    SciTech Connect (OSTI)

    Zhang, Bingqi

    2011-05-15

    The poly(diethylaminoethyl methacrylate) (PDEAEM) - Pluronic F127 - PDEAEM pentablock copolymer (PB) gene delivery vector system has been found to possess an inherent selectivity in transfecting cancer cells over non-cancer cells in vitro, without attaching any targeting ligands. In order to understand the mechanism of this selective transfection, three possible intracellular barriers to transfection were investigated in both cancer and non-cancer cells. We concluded that escape from the endocytic pathway served as the primary intracellular barrier for PB-mediated transfection. Most likely, PB vectors were entrapped and rendered non-functional in acidic lysosomes of non-cancer cells, but survived in less acidic lysosomes of cancer cells. The work highlights the importance of identifying intracellular barriers for different gene delivery systems and provides a new paradigm for designing targeting vectors based on intracellular differences between cell types, rather than through the use of targeting ligands. The PB vector was further developed to simultaneously deliver anticancer drugs and genes, which showed a synergistic effect demonstrated by significantly enhanced gene expression in vitro. Due to the thermosensitive gelation behavior, the PB vector packaging both drug and gene was also investigated for its in vitro sustained release properties by using polyethylene glycol diacrylate as a barrier gel to mimic the tumor matrix in vivo. Overall, this work resulted in the development of a gene delivery vector for sustained and selective gene delivery to tumor cells for cancer therapy.

  14. Articulating feedstock delivery device

    DOE Patents [OSTI]

    Jordan, Kevin

    2013-11-05

    A fully articulable feedstock delivery device that is designed to operate at pressure and temperature extremes. The device incorporates an articulating ball assembly which allows for more accurate delivery of the feedstock to a target location. The device is suitable for a variety of applications including, but not limited to, delivery of feedstock to a high-pressure reaction chamber or process zone.

  15. Non-destructively shattered mesoporous silica for protein drug...

    Office of Scientific and Technical Information (OSTI)

    Journal Article: Non-destructively shattered mesoporous silica for protein drug delivery Citation Details In-Document Search Title: Non-destructively shattered mesoporous silica ...

  16. The Integration of an Electro-hydraulic Manipulator Arm into a Self-contained Mobile Delivery System

    SciTech Connect (OSTI)

    Borland, Mark Wilson; Berry, Stephen Michael

    1999-04-01

    The Portable Articulated Arm Deployment System (PAADS) is a remotely controlled vehicle for delivering a tele-operated electro-hydraulic manipulator arm to a field deployable location. The self-contained system includes a boom vehicle with long reach capability, an electro-hydraulic manipulator arm, closed circuit television (CCTV) systems, and onboard tools. On board power systems consist of a self contained, propane fired 8 KW generator and an air compressor for pneumatic tools. The generator provides the power to run the air compressor as well as provide power to operate the 110 VAC auxiliary lighting system for the video cameras. The separate control console can be located up to 500 ft from the vehicle. PAADS is a fully integrated system, containing all equipment required to perform complex field operations. Hydraulic integration of the manipulator arm into the vehicle hydraulic drive system was necessary to eliminate the tether management of hoses, which extended vehicle operating range, minimized hydraulic pressure losses, and provided the opportunity to go to a radio frequency (RF) control system in the future, thereby eliminating the control cable. This paper presents the key decision points during system development. Emphasis is placed on ease of operator control and not on an intelligent machine approach. In addition, emphasis is placed on the philosophy of remote operation based on sound principles on integration.

  17. The Integration of an Electro-Hydraulic Manipulator Arm into a Self-Contained Mobile Delivery System

    SciTech Connect (OSTI)

    M. Borland; S. M. Berry

    1999-04-01

    The Portable Articulated Arm Deployment System (PAADS) is a remotely controlled vehicle for delivering a tele-operated electro-hydraulic manipulator arm to a field-deployable location. The self-contained system includes a boom vehicle with long reach capability, an electro-hydraulic manipulator arm, closed circuit television (CCTV) systems, and onboard tools. On board power systems consist of a self-contained, propane-fired 8-KW generator and an air compressor for pneumatic tools. The generator provides the power to run the air compressor as well as power to operate the 110-VAC auxiliary lighting system for the video cameras. The separate control console can be located up to 500 ft from the vehicle. PAADS is a fully integrated system, containing all equipment required to perform complex field operations. Hydraulic integration of the manipulator arm into the vehicle hydraulic drive system was necessary to eliminate the tether management of hoses, which extended vehicle operating range, minimized hydraulic pressure losses, and provided the opportunity to go to a radio frequency (RF) control system in the future, thereby eliminating the control cable. This paper presents the key decision points during system development. Emphasis is placed on ease of operator control and not on an intelligent machine approach. In addition, emphasis is placed on the philosophy of remote operation based on sound principles of integration.

  18. SU-D-207-05: Real-Time Intrafractional Motion Tracking During VMAT Delivery Using a Conventional Elekta CBCT System

    SciTech Connect (OSTI)

    Park, Yang-Kyun; Sharp, Gregory C.; Gierga, David P.; Winey, Brian A.; Ye, Sung-Joon

    2015-06-15

    Purpose: Real-time kV projection streaming capability has become recently available for Elekta XVI version 5.0. This study aims to investigate the feasibility and accuracy of real-time fiducial marker tracking during CBCT acquisition with or without simultaneous VMAT delivery using a conventional Elekta linear accelerator. Methods: A client computer was connected to an on-board kV imaging system computer, and receives and processes projection images immediately after image acquisition. In-house marker tracking software based on FFT normalized cross-correlation was developed and installed in the client computer. Three gold fiducial markers with 3 mm length were implanted in a pelvis-shaped phantom with 36 cm width. The phantom was placed on a programmable motion platform oscillating in anterior-posterior and superior-inferior directions simultaneously. The marker motion was tracked in real-time for (1) a kV-only CBCT scan with treatment beam off and (2) a kV CBCT scan during a 6-MV VMAT delivery. The exposure parameters per projection were 120 kVp and 1.6 mAs. Tracking accuracy was assessed by comparing superior-inferior positions between the programmed and tracked trajectories. Results: The projection images were successfully transferred to the client computer at a frequency of about 5 Hz. In the kV-only scan, highly accurate marker tracking was achieved over the entire range of cone-beam projection angles (detection rate / tracking error were 100.0% / 0.6±0.5 mm). In the kV-VMAT scan, MV-scatter degraded image quality, particularly for lateral projections passing through the thickest part of the phantom (kV source angle ranging 70°-110° and 250°-290°), resulting in a reduced detection rate (90.5%). If the lateral projections are excluded, tracking performance was comparable to the kV-only case (detection rate / tracking error were 100.0% / 0.8±0.5 mm). Conclusion: Our phantom study demonstrated a promising Result for real-time motion tracking using a

  19. Office of Electricity Delivery and Energy Reliability

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Comments of Cisco Systems to Office of Electricity Delivery and Energy Reliability Department of Energy in Response to Request for Information: Addressing Policy and Logistical Challenges to Smart Grid Implementation Issued September 13, 2010 FR Doc. 2010-23251 November 30, 2010 Cisco Systems provides these Comments in response to the Request for Information ("RFI") issued by the Office of Electricity Delivery and Energy Reliability of the Department of Energy ("DOE") on

  20. Asynchronous broadcast for ordered delivery between compute nodes in a parallel computing system where packet header space is limited

    DOE Patents [OSTI]

    Kumar, Sameer

    2010-06-15

    Disclosed is a mechanism on receiving processors in a parallel computing system for providing order to data packets received from a broadcast call and to distinguish data packets received at nodes from several incoming asynchronous broadcast messages where header space is limited. In the present invention, processors at lower leafs of a tree do not need to obtain a broadcast message by directly accessing the data in a root processor's buffer. Instead, each subsequent intermediate node's rank id information is squeezed into the software header of packet headers. In turn, the entire broadcast message is not transferred from the root processor to each processor in a communicator but instead is replicated on several intermediate nodes which then replicated the message to nodes in lower leafs. Hence, the intermediate compute nodes become "virtual root compute nodes" for the purpose of replicating the broadcast message to lower levels of a tree.

  1. Prescription Drugs

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Prescription Drugs Prescription Drugs Prescription drug benefits are determined by your medical plan. Contact Prime Therapeutics Prescription drug coverage for retirees Your Blue Cross and Blue Shield of New Mexico (BCBSNM) health plan includes a prescription drug benefit administered by Prime Therapeutics. The cost of the prescription drug plan is included in your medical premiums. Coverage The co-pays for prescription drugs are based on a 3-tier prescription drug benefit. Co-payments are

  2. SU-E-T-545: A MLC-Equipped Robotic Radiosurgery-Radiotherapy Combined System in Treating Hepatic Lesions: Delivery Efficiency as Compared to a Standard Linac for Treating Hepatic Lesions

    SciTech Connect (OSTI)

    Jin, L; Price, R; Wang, L; Meyer, J; Ma, C; Fan, J

    2014-06-01

    Purpose: The CyberKnife (CK) M6 Series introduced a mulitleaf collimator (MLC) beam for extending its capability to the conventional radiotherapy. This work is to investigate delivery efficiency of this system as compared to a standard Varian linac when treating hepatic lesions. Methods: Nine previously treated patients were divided into three groups with three patients in each. Group one: fractionated radiotherapy; Group two: SBRT-like treatments and Group three: fractionated radiotherapy targeting two PTVs. The clinically used plans were generated with the Eclipse treatment planning system (TPS). We re-planned these cases using a Mulitplan (MP) TPS for the CK M6 and normalized to the same PTV dose coverage. CK factors (CF) (defined as modulation scaling factor in this work), number of nodes (NN), number of MLC segments (NS) and beam delivery time (BT) with an estimated image interval of 60 seconds, were used for evaluation of delivery efficiency. Results: Generated plans from the MP and Eclipse TPS demonstrated the similar quality in terms of PTV confomality index, minimum and maximum PTV doses, and doses received by critical structures. Group one: CF ranged from 8.1 to 8.7, NN from 30 to 40, NS from 120 to 155 and BT from 20 to 23 minutes; group two: CF from 4.7 to 8.5, NN from 15 to 19, NS from 82 to 141 and BT from 18 to 24 minutes; and group three: CF from 7.9 to 10, NN from 47 to 49, NS from 110 to 113 and BT from 20 to 22 minutes. Conclusions: Delivery time is longer for the CK M6 than for the Varian linac (7.8 to 13.7 minutes). Further investigation will be necessary to determine if a PTV reduction from the tracking feature will shorten the delivery time without decreasing plan quality.

  3. Oncor Electric Delivery - Solar Photovoltaic Standard Offer Program...

    Energy.gov (indexed) [DOE]

    Summary Oncor Electric Delivery offers rebates to its customers that install photovoltaic (PV) systems on homes or other buildings.* Oncor customers of all rate classes...

  4. 1800 Engineered Safety Work Planning and Controls and HF Delivery...

    Office of Scientific and Technical Information (OSTI)

    Conference: 1800 Engineered Safety Work Planning and Controls and HF Delivery System. ... Country of Publication: United States Language: English Word Cloud More Like This Full ...

  5. ARM - Data Gathering and Delivery

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Gathering and Delivery Data Gathering and Delivery Collecting the Data The ARM Climate Research Facility instruments automatically collect data on surface and atmospheric ...

  6. Electricity Delivery and Energy Reliability

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Delivery and Energy Reliability The Office of Electricity Delivery and Energy Reliability ... to energy supply disruptions, such as electricity and fuel outages. * Smart Grid (14.4 ...

  7. Potential Carriers and Approaches for Hydrogen Delivery | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energy Carriers and Approaches for Hydrogen Delivery Potential Carriers and Approaches for Hydrogen Delivery Presentation by Matthew Hooks of TIAX at the Joint Meeting on Hydrogen Delivery Modeling and Analysis, May 8-9, 2007 deliv_analysis_hooks_carriers.pdf (254.09 KB) More Documents & Publications Summary of On-Board Storage Models and Analyses Analyses of Hydrogen Storage Materials and On-Board Systems Hydrogen Storage Systems Anlaysis Working Group Meeting, December 12, 2006

  8. Cybersecurity Procurement Language for Energy Delivery (April 2014) |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Procurement Language for Energy Delivery (April 2014) Cybersecurity Procurement Language for Energy Delivery (April 2014) Energy delivery systems, which are used to monitor and control the production, transfer, and distribution of energy, are critical to the effective and reliable operation of North America's energy infrastructure. Our twenty-first-century way of life is made possible by the vast network of processes enabled by these systems, as well as the

  9. National Electricity Delivery Division

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    (DOE) Office of Electricity Delivery and Energy Reliability (OE) National Electricity Delivery Division Julie Ann Smith, PhD September 24, 2015 The Federal Indian Trust Responsibility is a legal obligation under which the United States has charged itself with moral obligations of the highest responsibility and trust toward American Indian tribes. (Seminole Nation v. United States, 1942; Cherokee Nation v. Georgia, 1831). "When the trust responsibility is acknowledged and upheld by the

  10. Measurements of lateral penumbra for uniform scanning proton beams under various beam delivery conditions and comparison to the XiO treatment planning system

    SciTech Connect (OSTI)

    Rana, Suresh; Zeidan, Omar; Ramirez, Eric; Rains, Michael; Gao, Junfang; Zheng, Yuanshui

    2013-09-15

    Purpose: The main purposes of this study were to (1) investigate the dependency of lateral penumbra (80%–20% distance) of uniform scanning proton beams on various factors such as air gap, proton range, modulation width, compensator thickness, and depth, and (2) compare the lateral penumbra calculated by a treatment planning system (TPS) with measurements.Methods: First, lateral penumbra was measured using solid–water phantom and radiographic films for (a) air gap, ranged from 0 to 35 cm, (b) proton range, ranged from 8 to 30 cm, (c) modulation, ranged from 2 to 10 cm, (d) compensator thickness, ranged from 0 to 20 cm, and (e) depth, ranged from 7 to 15 cm. Second, dose calculations were computed in a virtual water phantom using the XiO TPS with pencil beam algorithm for identical beam conditions and geometrical configurations that were used for the measurements. The calculated lateral penumbra was then compared with the measured one for both the horizontal and vertical scanning magnets of our uniform scanning proton beam delivery system.Results: The results in the current study showed that the lateral penumbra of horizontal scanning magnet was larger (up to 1.4 mm for measurement and up to 1.0 mm for TPS) compared to that of vertical scanning magnet. Both the TPS and measurements showed an almost linear increase in lateral penumbra with increasing air gap as it produced the greatest effect on lateral penumbra. Lateral penumbra was dependent on the depth and proton range. Specifically, the width of lateral penumbra was found to be always lower at shallower depth than at deeper depth within the spread out Bragg peak (SOBP) region. The lateral penumbra results were less sensitive to the variation in the thickness of compensator, whereas lateral penumbra was independent of modulation. Overall, the comparison between the results of TPS with that of measurements indicates a good agreement for lateral penumbra, with TPS predicting higher values compared to

  11. Main chain acid-degradable polymers for the delivery of bioactive materials

    DOE Patents [OSTI]

    Frechet, Jean M. J.; Standley, Stephany M.; Jain, Rachna; Lee, Cameron C.

    2012-03-20

    Novel main chain acid degradable polymer backbones and drug delivery systems comprised of materials capable of delivering bioactive materials to cells for use as vaccines or other therapeutic agents are described. The polymers are synthesized using monomers that contain acid-degradable linkages cleavable under mild acidic conditions. The main chain of the resulting polymers readily degrade into many small molecules at low pH, but remain relatively stable and intact at physiological pH. The new materials have the common characteristic of being able to degrade by acid hydrolysis under conditions commonly found within the endosomal or lysosomal compartments of cells thereby releasing their payload within the cell. The materials can also be used for the delivery of therapeutics to the acidic regions of tumors and other sites of inflammation.

  12. Computational model, method, and system for kinetically-tailoring multi-drug chemotherapy for individuals

    DOE Patents [OSTI]

    Gardner, Shea Nicole

    2007-10-23

    A method and system for tailoring treatment regimens to individual patients with diseased cells exhibiting evolution of resistance to such treatments. A mathematical model is provided which models rates of population change of proliferating and quiescent diseased cells using cell kinetics and evolution of resistance of the diseased cells, and pharmacokinetic and pharmacodynamic models. Cell kinetic parameters are obtained from an individual patient and applied to the mathematical model to solve for a plurality of treatment regimens, each having a quantitative efficacy value associated therewith. A treatment regimen may then be selected from the plurlaity of treatment options based on the efficacy value.

  13. A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity

    SciTech Connect (OSTI)

    Kostadinova, Radina; Boess, Franziska; Suter, Laura; Weiser, Thomas; Singer, Thomas; Roth, Adrian

    2013-04-01

    Drug-induced liver injury (DILI) is the major cause for liver failure and post-marketing drug withdrawals. Due to species-specific differences in hepatocellular function, animal experiments to assess potential liabilities of drug candidates can predict hepatotoxicity in humans only to a certain extent. In addition to animal experimentation, primary hepatocytes from rat or human are widely used for pre-clinical safety assessment. However, as many toxic responses in vivo are mediated by a complex interplay among different cell types and often require chronic drug exposures, the predictive performance of hepatocytes is very limited. Here, we established and characterized human and rat in vitro three-dimensional (3D) liver co-culture systems containing primary parenchymal and non-parenchymal hepatic cells. Our data demonstrate that cells cultured on a 3D scaffold have a preserved composition of hepatocytes, stellate, Kupffer and endothelial cells and maintain liver function for up to 3 months, as measured by the production of albumin, fibrinogen, transferrin and urea. Additionally, 3D liver co-cultures maintain cytochrome P450 inducibility, form bile canaliculi-like structures and respond to inflammatory stimuli. Upon incubation with selected hepatotoxicants including drugs which have been shown to induce idiosyncratic toxicity, we demonstrated that this model better detected in vivo drug-induced toxicity, including species-specific drug effects, when compared to monolayer hepatocyte cultures. In conclusion, our results underline the importance of more complex and long lasting in vitro cell culture models that contain all liver cell types and allow repeated drug-treatments for detection of in vivo-relevant adverse drug effects. - Highlights: ? 3D liver co-cultures maintain liver specific functions for up to three months. ? Activities of Cytochrome P450s remain drug- inducible accross three months. ? 3D liver co-cultures recapitulate drug-induced liver toxicity observed

  14. Energy Department Announces up to $4 Million to Advance Hydrogen Delivery Technology Development

    Energy.gov [DOE]

    Up to $4 million will be made available for projects focused on innovative hydrogen delivery materials, components, and systems needed to establish the technical and cost feasibility for renewable and low carbon hydrogen delivery.

  15. Propane Bakery Delivery Step Vans

    Alternative Fuels and Advanced Vehicles Data Center

    Case Study - Propane Bakery Delivery Step Vans April 2016 1 Contents Background .......................................................................................................................................................................... 3 Motivation for Adopting Propane ................................................................................................................................... 3 Financial Benefits

  16. Office of Electricity Delivery

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Electricity Delivery and Energy Reliability Smart Grid R&D Program DOE Microgrid Workshop Report August 30-31, 2011 San Diego, California ii Acknowledgment The U.S. Department of Energy (DOE) would like to acknowledge the support provided by the organizations represented on the workshop planning committee in developing the workshop process and sessions. The preparation of this workshop report was coordinated by Energy & Environmental Resources Group, LLC (E2RG). The report content is

  17. Hydrogen Delivery Roadmap

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Delivery Technical Team Roadmap June 2013 This roadmap is a document of the U.S. DRIVE Partnership. U.S. DRIVE (United States Driving Research and Innovation for Vehicle efficiency and Energy sustainability) is a voluntary, non-binding, and nonlegal partnership among the U.S. Department of Energy; United States Council for Automotive Research (USCAR), representing Chrysler Group LLC, Ford Motor Company, and General Motors; Tesla Motors; five energy companies - BPAmerica, Chevron Corporation,

  18. Categorical Exclusion Determinations: Office of Electricity Delivery...

    Office of Environmental Management (EM)

    Electricity Delivery and Energy Reliability Categorical Exclusion Determinations: Office of Electricity Delivery and Energy Reliability Categorical Exclusion Determinations issued ...

  19. Hydrogen Delivery | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Delivery Hydrogen Delivery A viable hydrogen infrastructure requires that hydrogen be able to be delivered from where it's produced to the point of end-use, such as a dispenser at a refueling station or stationary power site. Infrastructure includes the pipelines, trucks, storage facilities, compressors, and dispensers involved in the process of delivering fuel. Delivery technology for hydrogen infrastructure is currently available commercially, and several U.S. companies deliver bulk hydrogen

  20. TO: Honorable Patricia Hoffman, Assistant Secretary for Electricity Delivery

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    TO: Honorable Patricia Hoffman, Assistant Secretary for Electricity Delivery and Energy Reliability, U.S. Department of Energy FROM: Electricity Advisory Committee (EAC) Richard Cowart, Chair DATE: September 25, 2014 RE: Expanding and Modernizing the Electric Power Delivery System for the 21 st Century Introduction The United States electricity system is undergoing more change than it has in many decades. The causes are numerous: a changing mix of resources driven by lowering prices, climate

  1. Nano compartments may aid drug delivery, catalyst design > Archived...

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    researcher Teeraporn Suteewong and graduate student Hiroaki Sai, have tweaked familiar "sol-gel" chemistry used to self-assemble porous silica particles, making the assembly shift...

  2. Molecule Nanoweaver Improves Drug Delivery and Treatment Efficacy...

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    along the synthetic route by using the powerful tool of solid-state NMR analyses. Upon development of a mature protocol, the Molecule Nanoweaver would operate on an assembly...

  3. Artificial Cells for Advanced Drug Delivery - Energy Innovation...

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    reactions. DescriptionOne such reaction is the hydrogenation of carbon dioxide to methanol. Alcohols interacts both molecularly and dissociatively with the single-crystalline...

  4. Hydrogen Distribution and Delivery Infrastructure

    SciTech Connect (OSTI)

    2008-11-01

    This 2-page fact sheet provides a brief introduction to hydrogen delivery technologies. Intended for a non-technical audience, it explains how hydrogen is transported and delivered today, the challenges to delivering hydrogen for use as a widespread energy carrier, and the research goals for hydrogen delivery.

  5. Hydrogen Delivery Technical Team Roadmap

    SciTech Connect (OSTI)

    2013-06-01

    The mission of the Hydrogen Delivery Technical Team (HDTT) is to enable the development of hydrogen delivery technologies, which will allow for fuel cell competitiveness with gasoline and hybrid technologies by achieving an as-produced, delivered, and dispensed hydrogen cost of $2-$4 per gallon of gasoline equivalent of hydrogen.

  6. Electro-osmotically driven liquid delivery method and apparatus

    DOE Patents [OSTI]

    Rakestraw, David J.; Anex, Deon S.; Yan, Chao; Dadoo, Rajeev; Zare, Richard N.

    1999-01-01

    Method and apparatus for controlling precisely the composition and delivery of liquid at sub-.mu.L/min flow rate. One embodiment of such a delivery system is an electro-osmotically driven gradient flow delivery system that generates dynamic gradient flows with sub-.mu.L/min flow rates by merging a plurality of electro-osmotic flows. These flows are delivered by a plurality of delivery arms attached to a mixing connector, where they mix and then flow into a receiving means, preferably a column. Each inlet of the plurality of delivery arms is placed in a corresponding solution reservoir. A plurality of independent programmable high-voltage power supplies is used to apply a voltage program to each of the plurality of solution reservoirs to regulate the electro-osmotic flow in each delivery arm. The electro-osmotic flow rates in the delivery arms are changed with time according to each voltage program to deliver the required gradient profile to the column.

  7. Electro-osmotically driven liquid delivery method and apparatus

    DOE Patents [OSTI]

    Rakestraw, D.J.; Anex, D.S.; Yan, C.; Dadoo, R.; Zare, R.N.

    1999-08-24

    Method and apparatus are disclosed for controlling precisely the composition and delivery of liquid at sub-{micro}L/min flow rate. One embodiment of such a delivery system is an electro-osmotically driven gradient flow delivery system that generates dynamic gradient flows with sub-{micro}L/min flow rates by merging a plurality of electro-osmotic flows. These flows are delivered by a plurality of delivery arms attached to a mixing connector, where they mix and then flow into a receiving means, preferably a column. Each inlet of the plurality of delivery arms is placed in a corresponding solution reservoir. A plurality of independent programmable high-voltage power supplies is used to apply a voltage program to each of the plurality of solution reservoirs to regulate the electro-osmotic flow in each delivery arm. The electro-osmotic flow rates in the delivery arms are changed with time according to each voltage program to deliver the required gradient profile to the column. 4 figs.

  8. Functionalized bimodal mesoporous silicas as carriers for controlled aspirin delivery

    SciTech Connect (OSTI)

    Gao Lin; Sun Jihong; Li Yuzhen

    2011-08-15

    The bimodal mesoporous silica modified with 3-aminopropyltriethoxysilane was performed as the aspirin carrier. The samples' structure, drug loading and release profiles were characterized with X-ray diffraction, scanning electron microscopy, N{sub 2} adsorption and desorption, Fourier transform infrared spectroscopy, TG analysis, elemental analysis and UV-spectrophotometer. For further exploring the effects of the bimodal mesopores on the drug delivery behavior, the unimodal mesoporous material MCM-41 was also modified as the aspirin carrier. Meantime, Korsmeyer-Peppas equation f{sub t}=kt{sup n} was employed to analyze the dissolution data in details. It is indicated that the bimodal mesopores are beneficial for unrestricted drug molecules diffusing and therefore lead to a higher loading and faster releasing than that of MCM-41. The results show that the aspirin delivery properties are influenced considerably by the mesoporous matrix, whereas the large pore of bimodal mesoporous silica is the key point for the improved controlled-release properties. - Graphical abstract: Loading (A) and release profiles (B) of aspirin in N-BMMs and N-MCM-41 indicated that BMMs have more drug loading capacity and faster release rate than that MCM-41. Highlights: > Bimodal mesoporous silicas (BMMs) and MCM-41 modified with amino group via post-treatment procedure. > Loading and release profiles of aspirin in modified BMMs and MCM-41. > Modified BMMs have more drug loading capacity and faster release rate than that modified MCM-41.

  9. Final Report - Hydrogen Delivery Infrastructure Options Analysis...

    Energy.gov (indexed) [DOE]

    The project objective was to develop an understanding of hydrogen delivery options and plan related R&D efforts. Final Report - Hydrogen Delivery Infrastructure Options Analysis ...

  10. Hydrogen Delivery Infrastructure Analysis, Options and Trade...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    the DOE Hydrogen Delivery High-Pressure Tanks and Analysis Project Review Meeting held ... Delivery Analysis and High Pressure Tanks R&D Project Review Meeting Agenda ...

  11. National Electric Delivery Technologies Roadmap: Transforming...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Delivery Technologies Roadmap: Transforming the Grid to Revolutionize Electric Power in North America National Electric Delivery Technologies Roadmap: Transforming the Grid to ...

  12. Aggressive Underwriting and Smart Product Delivery | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Aggressive Underwriting and Smart Product Delivery Aggressive Underwriting and Smart Product Delivery Presents AFC First's expert knowledge on lending products, financing, and ...

  13. Waste feed delivery planning at Hanford

    SciTech Connect (OSTI)

    Certa, Paul J.; West, Elizha B.; Rodriguez, Juissepp S.; Hohl, Ted M.; Larsen, Douglas C.; Ritari, Jaakob S.; Kelly, James W.

    2013-01-10

    The Integrated Waste Feed Delivery Plan (IWFDP) describes how waste feed will be delivered to the Waste Treatment and Immobilization Plant (WTP) to safely and efficiently accomplish the River Protection Project (RPP) mission. The IWFDP, which is integrated with the Baseline Case operating scenario, is comprised of three volumes. Volume 1 - Process Strategy provides an overview of waste feed delivery (WFD) and describes how the WFD system will be used to prepare and deliver feed to the WTP based on the equipment configuration and functional capabilities of the WFD system. Volume 2 - Campaign Plan describes the plans for the first eight campaigns for delivery to the WTP, evaluates projected feed for systematic issues, projects 242-A Evaporator campaigns, and evaluates double-shell tank (DST) space and availability of contingency feed. Volume 3 - Project Plan identifies the scope and timing of the DST and infrastructure upgrade projects necessary to feed the WTP, and coordinates over 30 projectized projects and operational activities that comprise the needed WFD upgrades.

  14. Hydraulic Hybrid Parcel Delivery Truck Deployment, Testing & Demonstration

    SciTech Connect (OSTI)

    Gallo, Jean-Baptiste

    2014-03-07

    Although hydraulic hybrid systems have shown promise over the last few years, commercial deployment of these systems has primarily been limited to Class 8 refuse trucks. In 2005, the Hybrid Truck Users Forum initiated the Parcel Delivery Working Group including the largest parcel delivery fleets in North America. The goal of the working group was to evaluate and accelerate commercialization of hydraulic hybrid technology for parcel delivery vehicles. FedEx Ground, Purolator and United Parcel Service (UPS) took delivery of the world’s first commercially available hydraulic hybrid parcel delivery trucks in early 2012. The vehicle chassis includes a Parker Hannifin hydraulic hybrid drive system, integrated and assembled by Freightliner Custom Chassis Corp., with a body installed by Morgan Olson. With funding from the U.S. Department of Energy, CALSTART and its project partners assessed the performance, reliability, maintainability and fleet acceptance of three pre-production Class 6 hydraulic hybrid parcel delivery vehicles using information and data from in-use data collection and on-road testing. This document reports on the deployment of these vehicles operated by FedEx Ground, Purolator and UPS. The results presented provide a comprehensive overview of the performance of commercial hydraulic hybrid vehicles in parcel delivery applications. This project also informs fleets and manufacturers on the overall performance of hydraulic hybrid vehicles, provides insights on how the technology can be both improved and more effectively used. The key findings and recommendations of this project fall into four major categories: -Performance, -Fleet deployment, -Maintenance, -Business case. Hydraulic hybrid technology is relatively new to the market, as commercial vehicles have been introduced only in the past few years in refuse and parcel delivery applications. Successful demonstration could pave the way for additional purchases of hydraulic hybrid vehicles throughout the

  15. Variable delivery, fixed displacement pump

    DOE Patents [OSTI]

    Sommars, Mark F.

    2001-01-01

    A variable delivery, fixed displacement pump comprises a plurality of pistons reciprocated within corresponding cylinders in a cylinder block. The pistons are reciprocated by rotation of a fixed angle swash plate connected to the pistons. The pistons and cylinders cooperate to define a plurality of fluid compression chambers each have a delivery outlet. A vent port is provided from each fluid compression chamber to vent fluid therefrom during at least a portion of the reciprocal stroke of the piston. Each piston and cylinder combination cooperates to close the associated vent port during another portion of the reciprocal stroke so that fluid is then pumped through the associated delivery outlet. The delivery rate of the pump is varied by adjusting the axial position of the swash plate relative to the cylinder block, which varies the duration of the piston stroke during which the vent port is closed.

  16. Hydrogen Delivery Infrastructure Options Analysis

    Fuel Cell Technologies Publication and Product Library (EERE)

    This report, by the Nexant team, documents an in-depth analysis of seven hydrogen delivery options to identify the most cost-effective hydrogen infrastructure for the transition and long term. The pro

  17. Hydrogen Distribution and Delivery Infrastructure

    Fuel Cell Technologies Publication and Product Library (EERE)

    This 2-page fact sheet provides a brief introduction to hydrogen delivery technologies. Intended for a non-technical audience, it explains how hydrogen is transported and delivered today, the challen

  18. Radioisotope Power System Delivery, Ground Support and Nuclear Safety Implementation: Use of the Multi-Mission Radioisotope Thermoelectric Generator for the NASA's Mars Science Laboratory

    SciTech Connect (OSTI)

    S.G. Johnson; K.L. Lively; C.C. Dwight

    2014-07-01

    Radioisotope power systems have been used for over 50 years to enable missions in remote or hostile environments. They are a convenient means of supplying a few milliwatts up to a few hundred watts of useable, long-term electrical power. With regard to use of a radioisotope power system, the transportation, ground support and implementation of nuclear safety protocols in the field is a complex process that requires clear identification of needed technical and regulatory requirements. The appropriate care must be taken to provide high quality treatment of the item to be moved so it arrives in a condition to fulfill its missions in space. Similarly it must be transported and managed in a manner compliant with requirements for shipment and handling of special nuclear material. This presentation describes transportation, ground support operations and implementation of nuclear safety and security protocols for a radioisotope power system using recent experience involving the Multi-Mission Radioisotope Thermoelectric Generator for National Aeronautics and Space Administration’s Mars Science Laboratory, which launched in November of 2011.

  19. Hydrogen Delivery Infrastructure Option Analysis

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Hydrogen Delivery Infrastructure Option Analysis Option Analysis DOE and FreedomCAR & Fuel Partnership Hydrogen Delivery and On-Board Storage Analysis Workshop January 25, 2005 Washington DC This presentation does not contain any proprietary or confidential information Tan-Ping Chen Nexant Jim Campbell Bhadra Grover Air Liquide Stefan Unnasch TIAX Glyn Hazelden GTI Graham Moore Chevron Matt Ringer NREL Ray Hobbs Pinnacle West 2 Presentation Outline Project Background Knowledge Collected and

  20. Hydrogen Delivery Technology Roadmap, November 2005

    Fuel Cell Technologies Publication and Product Library (EERE)

    Document describing plan for research into and development of hydrogen delivery technology for transportation applications.

  1. Hydrogen Delivery Roadmap | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Delivery Roadmap Hydrogen Delivery Roadmap The mission of the Hydrogen Delivery Technical Team (HDTT) is to enable the development of hydrogen delivery technologies, which will allow for fuel cell competitiveness with gasoline and hybrid technologies by achieving an as-produced, delivered, and dispensed hydrogen cost of $2-$4 per gallon of gasoline equivalent of hydrogen. hdtt_roadmap_june2013.pdf (1.55 MB) More Documents & Publications US DRIVE Hydrogen Delivery Technical Team Roadmap

  2. Final Report - Hydrogen Delivery Infrastructure Options Analysis |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy - Hydrogen Delivery Infrastructure Options Analysis Final Report - Hydrogen Delivery Infrastructure Options Analysis This report, by the Nexant team, documents an in-depth analysis of seven hydrogen delivery options to identify the most cost-effective hydrogen infrastructure for the transition and long term. The project objective was to develop an understanding of hydrogen delivery options and plan related R&D efforts. Final Report - Hydrogen Delivery Infrastructure

  3. Hydrogen Delivery Related Links | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Delivery » Hydrogen Delivery Related Links Hydrogen Delivery Related Links The following resources provide details about U.S. Department of Energy (DOE)-funded hydrogen delivery activities, research plans and roadmaps, models and tools, and additional related links. DOE-Funded Hydrogen Delivery Activities Each year, hydrogen and fuel cell projects funded by DOE's Hydrogen and Fuel Cells Program are reviewed for their merit during an Annual Merit Review and Peer Evaluation Meeting. View posters

  4. H2A Delivery Models and Results

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Delivery Models and Results Marianne Mintz, Jerry Gillette, Amgad Elgowainy, Argonne National Laboratory Matt Ringer, National Renewable Energy Laboratory Daryl Brown, Pacific Northwest National Laboratory Tracy Carole, Energetics Mark Paster, DOE DOE and FreedomCAR & Fuel Partnership Hydrogen Delivery and On-Board Storage Analysis Workshop January 25, 2006 H2A Delivery Presentation Outline * DOE Delivery Goals * H2A Project - Background - Approach & key assumptions * Delivery Scenarios

  5. Spontaneous Liver Rupture After Treatment With Drug-Eluting Beads...

    Office of Scientific and Technical Information (OSTI)

    Country of Publication: United States Language: English Subject: 62 RADIOLOGY AND NUCLEAR ... DRUGS; BODY; CARCINOMAS; DIGESTIVE SYSTEM; DISEASES; DRUGS; FAILURES; GLANDS; ...

  6. Hydrogen Delivery Options and Issues

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Options and Issues Mark Paster DOE August, 2006 Scope * From the end point of central or distributed production (300 psi H2) to and including the dispenser at a refueling station or stationary power site - GH2 Pipelines and Trucks, LH2 Trucks, Carriers <$1.00/kg of Hydrogen by 2017 Hydrogen Delivery H2 Delivery Current Status * Technology - GH2 Tube Trailers: ~340 kg, ~2600 psi - LH2 Trucks: ~3900 kg - Pipelines: up to 1500 psi (~630 miles in the U.S.) - Refueling Site Operations

  7. Autothermal hydrogen storage and delivery systems

    DOE Patents [OSTI]

    Pez, Guido Peter; Cooper, Alan Charles; Scott, Aaron Raymond

    2011-08-23

    Processes are provided for the storage and release of hydrogen by means of dehydrogenation of hydrogen carrier compositions where at least part of the heat of dehydrogenation is provided by a hydrogen-reversible selective oxidation of the carrier. Autothermal generation of hydrogen is achieved wherein sufficient heat is provided to sustain the at least partial endothermic dehydrogenation of the carrier at reaction temperature. The at least partially dehydrogenated and at least partially selectively oxidized liquid carrier is regenerated in a catalytic hydrogenation process where apart from an incidental employment of process heat, gaseous hydrogen is the primary source of reversibly contained hydrogen and the necessary reaction energy.

  8. Energy Delivery Systems Cybersecurity | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    The CEDS program emphasizes collaboration among the government, industry, universities, national laboratories, and end users to advance research and development in cybersecurity...

  9. Opto-acoustic recanilization delivery system

    DOE Patents [OSTI]

    Visuri, Steven R.; Da Silva, Luiz B.; Celliers, Peter M.; London, Richard A.; Benett, William; Broughton, Kathryn; Esch, Victor

    2002-01-01

    Fiber delivered laser pulses emulsify thrombus by mechanical stresses that include a combination of pressure, tension and shear stress. Laser radiation is delivered to the locality of a thrombus and the radiation is absorbed by blood, blood dot, or other present materials. The combination of a leading pressure wave and subsequent vapor bubble cause efficient, emulsification of thrombus. Operating the laser in a low average power mode alleviates potential thermal complications. The laser is operated in a high repetition rate mode to take advantage of ultrasound frequency effects of thrombus dissolution as well as to decrease the total procedure time. Specific parameter ranges for operation are described. The device includes optical fibers surrounding a lumen intended for flow of a cooling agent. The fibers may be arranged concentrically around the lumen to deliver radiation and heat over as large an area as possible. An alternative design approach incorporates the optical fibers into the wall of the guiding catheter and utilizes the catheter lumen as the cooling channel. An eccentric tip enables rotation of the device to address all parts of the vasculature. The eccentricity can be provided via a variety of means: spring dip, balloon, protrusion, etc.

  10. Steerable/distance enhanced penetrometer delivery system

    SciTech Connect (OSTI)

    Amini, A.; Shenhar, J.; Lum, K.D.

    1995-10-01

    The first steps toward contaminant plume containment and remediation are detection and mapping of the plume. Penetrometers can be used to map the plume efficiently and also provide the means for in-situ sampling and remediation. In traditional penetrometer applications, the instrumentation package located at the tip measures soil resistance. However, for environmental monitoring purposes, an array of environmental sensors is packed inside the penetrometer rods for in-situ sampling and analysis, or for collection of laboratory samples. At present, penetrometer applications are limited primarily to vertical pushes and because of their heavy weight, the use of penetrometer trucks over shallow buried storage tanks is restricted. To close the technology gap in the use of penetrometers for environmental purposes, UTD took the initiative by developing a new position location device referred to as POLO (short for POsition LOcator), which provides real-time position location without blocking downhole access for environmental sensors. The next step taken was the initiation of work to make penetrometers steerable and capable of greater penetration capabilities. The product of this work will be a relatively lightweight vibratory steerable penetrometer that can provide greater penetration capability than traditional penetrometers of the same weight, permitting applications over shallow buried storage tanks.

  11. Radionuclide-binding compound, a radionuclide delivery system, a method of making a radium complexing compound, a method of extracting a radionuclide, and a method of delivering a radionuclide

    DOE Patents [OSTI]

    Fisher, Darrell R.; Wai, Chien M.; Chen, Xiaoyuan

    2000-01-01

    The invention pertains to compounds which specifically bind radionuclides, and to methods of making radionuclide complexing compounds. In one aspect, the invention includes a radionuclide delivery system comprising: a) a calix[n]arene-crown-[m]-ether compound, wherein n is an integer greater than 3, and wherein m is an integer greater than 3, the calix[n]arene-crown-[m]-ether compound comprising at least two ionizable groups; and b) an antibody attached to the calix[n]arene-crown-[m]-ether compound. In another aspect, the invention includes a method of making a radium complexing compound, comprising: a) providing a calix[n]arene compound, wherein n is an integer greater than 3, the calix[n]arene compound comprising n phenolic hydroxyl groups; b) providing a crown ether precursor, the crown ether precursor comprising a pair of tosylated ends; c) reacting the pair of tosylated ends with a pair of the phenolic hydroxyl groups to convert said pair of phenolic hydroxyl groups to ether linkages, the ether linkages connecting the crown ether precursor to the calix[n]arene to form a calix[n]arene-crown-[m]-ether compound, wherein m is an integer greater than 3; d) converting remaining phenolic hydroxyl groups to esters; e) converting the esters to acids, the acids being proximate a crown-[m]-ether portion of the calix[n]arene-crown-[m]-ether compound; and f) providing a Ra.sup.2+ ion within the crown-[m]-ether portion of the calix[n]arene-crown-[m]-ether compound.

  12. Inexpensive Delivery of Compressed Hydrogen with Advanced Vessel...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    of H 2 drive storage and delivery costs (capital, energy, and transport) Today's commercial hydrogen delivery approaches occupy extreme delivery strategy spaces LH 2 2500 ...

  13. Agenda for the Hydrogen Delivery and Onboard Storage Analysis...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Hydrogen Delivery and Onboard Storage Analysis Workshop Agenda for the Hydrogen Delivery and Onboard Storage Analysis Workshop Agenda for the Hydrogen Delivery and Onboard Storage ...

  14. April 7 Webinar on OE’s Resilient Electricity Delivery Infrastructure Initiative FOA

    Office of Energy Efficiency and Renewable Energy (EERE)

    On April 7, Dan Ton, Acting Deputy Assistant Secretary, Dr. Imre Gyuk, Manager of the Energy Storage Program, and Dr. Carol Hawk, Manger of the Cybersecurity for Energy Delivery Systems Program, will be featured speakers during a webinar on OE’s Resilient Electricity Delivery Infrastructure Initiative (REDI) Funding Opportunity Announcement. The Resilient Electricity Delivery Infrastructure Initiative FOA is focused on local and tribal governments that experienced a Presidentially Declared Major Disaster over the past 30 years. The awards will help communities deploy smart grid tools and technologies that will help decision makers and resource managers improve recovery of electricity delivery services in their communities.

  15. Purchase, Delivery, and Storage of Gases

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Purchase, Delivery, and Storage of Gases Print ALS users should follow Berkeley Lab policy, as described below, for the purchase, delivery, storage, and use of all gases at the...

  16. Waste feed delivery test and evaluation plan

    SciTech Connect (OSTI)

    O'TOOLE, S.M.

    1999-09-30

    This plan documents the Waste Feed Delivery Program test and evaluation planning and implementation approach. The purpose of this document is to define and communicate the Waste Feed Delivery Program Test and Evaluation scope, objectives, planning and implementation approach.

  17. Delivery Tech Team | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Delivery Tech Team Delivery Tech Team Presentation by 02-Parks to DOE Hydrogen Pipeline R&D Project Review Meeting held January 5-6, 2005 at Oak Ridge National Laboratory in Oak Ridge, Tennessee. 02_parks_freedomcar.pdf (674.46 KB) More Documents & Publications Overview of FreedomCAR & Fuels Partnership/DOE Delivery Program Hydrogen Delivery Options and Issues President's Hydrogen Fuel Initiative

  18. Strategic Ground Delivery Services | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Ground Delivery Services Strategic Ground Delivery Services Use of New Strategically Source Agreement UPS.pdf.pdf (96.79 KB) More Documents & Publications POLICY FLASH 2010-42 Use of New Strategically Sourced Blanket Purchase Agreement for Domestic Delivery Services with United Parcel Service Minutes from the Print and Mail Managers Exchange Forum Teleconferences

  19. Waste Feed Delivery Environmental Permits and Approvals Plan

    SciTech Connect (OSTI)

    TOLLEFSON, K.S.

    2000-01-18

    This plan describes the environmental permits approvals, and other requirements that may affect establishment of a waste feed delivery system for the Hanford Site's River Protection Project. This plan identifies and screens environmental standards for potential applicability, outlines alternatives for satisfying applicable standards, and describes preferred permitting and approval approaches.

  20. Nanoparticle-Based Brachytherapy Spacers for Delivery of Localized Combined Chemoradiation Therapy

    SciTech Connect (OSTI)

    Kumar, Rajiv; Belz, Jodi; Markovic, Stacey; Jadhav, Tej; Fowle, William; Niedre, Mark; Cormack, Robert; Makrigiorgos, Mike G.; Sridhar, Srinivas

    2015-02-01

    Purpose: In radiation therapy (RT), brachytherapy-inert source spacers are commonly used in clinical practice to achieve high spatial accuracy. These implanted devices are critical technical components of precise radiation delivery but provide no direct therapeutic benefits. Methods and Materials: Here we have fabricated implantable nanoplatforms or chemoradiation therapy (INCeRT) spacers loaded with silica nanoparticles (SNPs) conjugated containing a drug, to act as a slow-release drug depot for simultaneous localized chemoradiation therapy. The spacers are made of poly(lactic-co-glycolic) acid (PLGA) as matrix and are physically identical in size to the commercially available brachytherapy spacers (5 mm × 0.8 mm). The silica nanoparticles, 250 nm in diameter, were conjugated with near infrared fluorophore Cy7.5 as a model drug, and the INCeRT spacers were characterized in terms of size, morphology, and composition using different instrumentation techniques. The spacers were further doped with an anticancer drug, docetaxel. We evaluated the in vivo stability, biocompatibility, and biodegradation of these spacers in live mouse tissues. Results: The electron microscopy studies showed that nanoparticles were distributed throughout the spacers. These INCeRT spacers remained stable and can be tracked by the use of optical fluorescence. In vivo optical imaging studies showed a slow diffusion of nanoparticles from the spacer to the adjacent tissue in contrast to the control Cy7.5-PLGA spacer, which showed rapid disintegration in a few days with a burst release of Cy7.5. The docetaxel spacers showed suppression of tumor growth in contrast to control mice over 16 days. Conclusions: The imaging with the Cy7.5 spacer and therapeutic efficacy with docetaxel spacers supports the hypothesis that INCeRT spacers can be used for delivering the drugs in a slow, sustained manner in conjunction with brachytherapy, in contrast to the rapid clearance of the drugs when

  1. Hydrogen Distribution and Delivery Fact Sheet | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Distribution and Delivery Fact Sheet Hydrogen Distribution and Delivery Fact Sheet Fact sheet produced by the Fuel Cell Technologies Office describing hydrogen distribution and delivery infrastructure. Hydrogen Distribution and Delivery (4.79 MB) More Documents & Publications Hydrogen Delivery Roadmap US DRIVE Hydrogen Delivery Technical Team Roadmap

  2. Drug Retention Times

    SciTech Connect (OSTI)

    Center for Human Reliability Studies

    2007-05-01

    The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user.

  3. Drug Retention Times

    SciTech Connect (OSTI)

    Center for Human Reliability Studies

    2007-05-01

    The purpose of this monograph is to provide information on drug retention times in the human body. The information provided is based on plausible illegal drug use activities that might be engaged in by a recreational drug user

  4. Evaluation of Retrofit Delivery Packages

    SciTech Connect (OSTI)

    Berman, M.; Smith, P.; Porse, E.

    2013-07-01

    Residential energy retrofit activities are a critical component of efforts to increase energy efficiency in the U.S. building stock; however, retrofits account for a small percentage of aggregate energy savings at relatively high per unit costs. This report by Building America research team, Alliance for Residential Building Innovation (ARBI), describes barriers to widespread retrofits and evaluates opportunities to improve delivery of home retrofit measures by identifying economies of scale in marketing, energy assessments, and bulk purchasing through pilot programs in portions of Sonoma, Los Angeles, and San Joaquin Counties, CA. These targeted communities show potential and have revealed key strategies for program design, as outlined in the report.

  5. Multirate delivery of multiple therapeutic agents from metal-organic frameworks

    SciTech Connect (OSTI)

    McKinlay, Alistair C.; Allan, Phoebe K.; Renouf, Catherine L.; Duncan, Morven J.; Wheatley, Paul S.; Warrender, Stewart J.; Dawson, Daniel; Ashbrook, Sharon E.; Gil, Barbara; Marszalek, Bartosz; Düren, Tina; Williams, Jennifer J.; Charrier, Cedric; Mercer, Derry K.; Teat, Simon J.; Morris, Russell E.

    2014-12-01

    The highly porous nature of metal-organic frameworks (MOFs) offers great potential for the delivery of therapeutic agents. Here, we show that highly porous metal-organic frameworks can be used to deliver multiple therapeutic agents—a biologically active gas, an antibiotic drug molecule, and an active metal ion—simultaneously but at different rates. The possibilities offered by delivery of multiple agents with different mechanisms of action and, in particular, variable timescales may allow new therapy approaches. Here, we show that the loaded MOFs are highly active against various strains of bacteria.

  6. Multirate delivery of multiple therapeutic agents from metal-organic frameworks

    DOE PAGES-Beta [OSTI]

    McKinlay, Alistair C.; Allan, Phoebe K.; Renouf, Catherine L.; Duncan, Morven J.; Wheatley, Paul S.; Warrender, Stewart J.; Dawson, Daniel; Ashbrook, Sharon E.; Gil, Barbara; Marszalek, Bartosz; et al

    2014-12-01

    The highly porous nature of metal-organic frameworks (MOFs) offers great potential for the delivery of therapeutic agents. Here, we show that highly porous metal-organic frameworks can be used to deliver multiple therapeutic agentsa biologically active gas, an antibiotic drug molecule, and an active metal ionsimultaneously but at different rates. The possibilities offered by delivery of multiple agents with different mechanisms of action and, in particular, variable timescales may allow new therapy approaches. Here, we show that the loaded MOFs are highly active against various strains of bacteria.

  7. Twelve-Month Evaluation of UPS Diesel Hybrid Electric Delivery Vans

    SciTech Connect (OSTI)

    Lammert, M.

    2009-12-01

    Results of an NREL study of a parallel hybrid electric-diesel propulsion system in United Parcel Service-operated delivery vans show that the hybrids had higher fuel economy than standard diesel vans.

  8. Potential Carriers and Approaches for Hydrogen Delivery

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Carriers and Potential Carriers and Approaches for Hydrogen Approaches for Hydrogen Delivery Delivery TIAX LLC 1601 S. D Anza Blvd. Cupertino CA, 95014 Tel. 408-517-1550 Reference: D0348 © 2007 TIAX LLC Hydrogen Delivery Analysis Meeting May 8-9, 2007 Columbia, Maryland Matthew Hooks Stefan Unnasch Stephen Lasher 1 Novel Hydrogen Carriers Project Overview Cost Density (wt. and vol.) Energy requirements Forecourt storage requirements Codes and standards H H 2 2 Plant, Liquefier, LH Plant,

  9. Delivery and Receipt | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Delivery and Receipt Delivery and Receipt Delivery and Receipt of Personal Property Acquired by Purchase Card at Headquarters Receiving Items Purchased with the Purchase Card that are Shipped or Delivered by the Vendor All personal property acquired by using the purchase card should generally be delivered to and processed by the receiving office (loading dock). This will ensure inventory control identification, as appropriate and recording in the personal property management records. The

  10. H2A Delivery Components Model and Analysis

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Hydrogen Delivery Components Model Matt Ringer National Renewable Energy Laboratory February 8, 2005 Other Team Members: Mark Paster: DOE Marianne Mintz, Jerry Gillette, Jay Burke: ANL Daryl Brown: PNNL Joan Ogden: UC Davis H2A Delivery Outline * Hydrogen delivery definition * H2A Delivery Component Model - Methodology - Components included - Key Assumptions * Spreadsheet demonstration H2A Delivery Hydrogen Delivery * Hydrogen delivery and storage defined as the complete set of equipment and

  11. Alane for Hydrogen Storage and Delivery

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Alane for Hydrogen Storage and Delivery June 2012 BROOKHAVEN NATIONAL LABORATORY Why Hydrogen? * Oil is a limited resource, generates green house gas and much of the worlds supply ...

  12. 2014 Revenue for Delivery Service Providers

    U.S. Energy Information Administration (EIA) (indexed site)

    Revenue for Delivery Service Providers" "(Data from form EIA-861 schedule 4C)" ,,,"Revenue (Thousands Dollars)" "Entity","State","Ownership","Residential","Commercial","Industrial"...

  13. Carbon NanoFiber Systems for Tissue Interfacing - Energy Innovation Portal

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Advanced Materials Advanced Materials Find More Like This Return to Search Carbon NanoFiber Systems for Tissue Interfacing Platform Technology for Electrophysiological Interfacing and for Drug and Gene Delivery Oak Ridge National Laboratory Contact ORNL About This Technology Technology Marketing Summary Scientists at ORNL have created vertically aligned carbon nano?fibers (VACNF) that are well suited for cell and tissue interfacing applications, such as electrophysiological stimulus and

  14. Hydrogen Delivery Infrastructure Option Analysis | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Option Analysis Hydrogen Delivery Infrastructure Option Analysis Presentation on hydrogen delivery infrastructure option analysis prepared for DOE. wkshp_storage_chen.pdf (1.13 MB) More Documents & Publications Hydrogen Delivery Options and Issues H2A Delivery Models and Results Potential Carriers and Approaches for Hydrogen Delivery

  15. TIGER -- A technology to improve the delivery capability of nuclear bombs and the survivability of the delivery aircraft

    SciTech Connect (OSTI)

    1980-12-31

    The TIGER (Terminal guided and Extended-Range) Program was initiated in 1972 to study improved delivery capabilities for stockpiled tactical nuclear bombs. The Southeast Asia conflict fostered the development of air-delivered standoff conventional weapons utilizing terminal guidance systems. SNL initiated the TIGER program to determine if current nuclear bombs could be provided with a similarly accurate standoff capabilities. These conventional weapon delivery techniques, while allowing highly accurate attack, generally require entering the target area at high altitude to establish line of sight to the target. In parallel with the TIGER program, system studies analyzed this concept and showed marked improvement in aircraft and weapon survivability with moderate standoff (10--20 km) if low level deliveries (60 m) could be accomplished. As a result of this work, the TIGER program was redirected in early 1974 to demonstrate a standoff bomb with good accuracy (90 m CEP) when delivered from low flying aircraft. This program redirection resulted in the selection of an inertial guidance system to replace the earlier terminal guidance systems. This program was called the Extended-Range Bomb (ERB). In May 1974, a joint Air Force/DOE study identified the desirability of having a single tactical weapon which could be employed against either fixed, preselected targets, or mobile battlefield targets. Studies conducted on the ERB system showed that the inertially guided weapon could fly not only the standoff mission but also a return-to-target mission against the mobile battlefield targets whose locations are not known accurately enough to use a standoff delivery. The ERB program evolved from these initial investigations into an exploratory program to develop the hardware and demonstrate the technology required to fly standoff and return-to-target trajectories. The application of this technology in the form of field retrofit kits to the B61 bomb is called TIGER II.

  16. Integrated Security System | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    More Documents & Publications Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentations - Vulnerability and Intrusion Detection Protecting Intelligent Distributed ...

  17. Statement from DOE's Chief Spokesperson Andrew Beck Regarding Delivery of

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    SPR Oil to Marathon Petroleum Company | Department of Energy SPR Oil to Marathon Petroleum Company Statement from DOE's Chief Spokesperson Andrew Beck Regarding Delivery of SPR Oil to Marathon Petroleum Company September 8, 2008 - 3:20pm Addthis WASHINGTON, DC - Today, September 8, 2008, the U.S. Department of Energy will deliver 250,000 barrels of oil from the Strategic Petroleum Reserve to Marathon Petroleum Company's Midwest refineries along the Capline pipeline system. The oil was

  18. Statement from DOE's Chief Spokesperson Andrew Beck Regarding Delivery of

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Strategic Petroleum Reserve Oil | Department of Energy Strategic Petroleum Reserve Oil Statement from DOE's Chief Spokesperson Andrew Beck Regarding Delivery of Strategic Petroleum Reserve Oil September 14, 2008 - 3:43pm Addthis WASHINGTON - The U.S. Department of Energy has agreed to deliver 200,000 barrels of emergency exchange oil from the Strategic Petroleum Reserve to ConocoPhillips Company's Wood River refinery along the Capline pipeline system. The Department will also deliver an

  19. Research | Energy Systems Integration | NREL

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    and demonstrating innovative technologies and strategies to ensure that our energy sources, demand-response programs, and delivery systems can work together optimally as a system. ...

  20. STATEMENT OF PATRICIA HOFFMAN ASSISTANT SECRETARY FOR ELECTRICITY DELIVERY AND ENERGY RELIABILITY

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    APPROPRIATIONS SUBCOMMITTEE ON ENERGY AND WATER DEVELOPMENT MARCH 27, 2012 Mr. Chairman and Members of the Committee, thank you for the opportunity to appear before you today to discuss the President's Fiscal Year (FY) 2013 budget for the Department of Energy's (DOE) Office of Electricity Delivery and Energy Reliability (OE). It is the mission of this office to lead national efforts to modernize the electricity delivery system, enhance the security and reliability of America's energy

  1. Secretary Steven Chu's Remarks as Prepared for Delivery to the...

    Office of Environmental Management (EM)

    Secretary Steven Chu's Remarks as Prepared for Delivery to the DOE Tribal Summit Secretary Steven Chu's Remarks as Prepared for Delivery to the DOE Tribal Summit Secretary Steven...

  2. Improvements to Hydrogen Delivery Scenario Analysis Model (HDSAM...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Improvements to Hydrogen Delivery Scenario Analysis Model (HDSAM) and Results Improvements to Hydrogen Delivery Scenario Analysis Model (HDSAM) and Results This presentation by ...

  3. Special Delivery for Sustainability: Clean Cities Supports UPS...

    Energy Savers

    Special Delivery for Sustainability: Clean Cities Supports UPS in Expanding Natural Gas Operations Special Delivery for Sustainability: Clean Cities Supports UPS in Expanding ...

  4. Natural Gas Deliveries to Commercial Consumers (Including Vehicle...

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Deliveries to Commercial Consumers (Including Vehicle Fuel through 1996) in the U.S. (Million Cubic Feet) Natural Gas Deliveries to Commercial Consumers (Including Vehicle Fuel ...

  5. Joint Meeting on Hydrogen Delivery Modeling and Analysis Meeting...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Agenda Joint Meeting on Hydrogen Delivery Modeling and Analysis Meeting Agenda Agenda for the Joint Meeting on Hydrogen Delivery Modeling and Analysis, May 8-9, 2007 ...

  6. Joint Meeting on Hydrogen Delivery Modeling and Analysis, May...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Joint Meeting on Hydrogen Delivery Modeling and Analysis, May 8-9, 2007, Discussion ... the Joint Meeting on Hydrogen Delivery Modeling and Analysis, May 8-9, 2007. ...

  7. Joint Meeting on Hydrogen Delivery Modeling and Analysis Meeting...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Joint Meeting on Hydrogen Delivery Modeling and Analysis Meeting Attendees List Attendee list from the Joint Meeting on Hydrogen Delivery Modeling and Analysis, May 8-9, 2007 ...

  8. Liquid Hydrogen Production and Delivery from a Dedicated Wind...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Hydrogen Production and Delivery from a Dedicated Wind Power Plant Liquid Hydrogen Production and Delivery from a Dedicated Wind Power Plant This May 2012 study assesses the costs ...

  9. H2A Hydrogen Delivery Infrastructure Analysis Models and Conventional...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    A Hydrogen Delivery Infrastructure Analysis Models and Conventional Pathway Options Analysis Results - Interim Report H2A Hydrogen Delivery Infrastructure Analysis Models and ...

  10. 2013 Annual Planning Summary for the Office of Electricity Delivery...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Electricity Delivery and Energy Reliability 2013 Annual Planning Summary for the Office of Electricity Delivery and Energy Reliability The ongoing and projected Environmental ...

  11. Washington Natural Gas Exports (No Intransit Deliveries) (Million...

    U.S. Energy Information Administration (EIA) (indexed site)

    Exports (No Intransit Deliveries) (Million Cubic Feet) Washington Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4...

  12. 2012 Annual Planning Summary for Electricity Delivery and Energy...

    Energy Savers

    Electricity Delivery and Energy Reliability 2012 Annual Planning Summary for Electricity Delivery and Energy Reliability The ongoing and projected Environmental Assessments and ...

  13. Office of Electricity Delivery And Energy Reliability To Hold...

    Office of Environmental Management (EM)

    Office of Electricity Delivery And Energy Reliability To Hold Technical Conference On The Design Of Future Electric Transmission Office of Electricity Delivery And Energy ...

  14. H2A Delivery: Forecourt Compression & Storage Optimization (Part...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Delivery: Forecourt Compression & Storage Optimization (Part II) H2A Delivery: Forecourt Compression & Storage Optimization (Part II) Presentation by Matthew Hooks of TIAX at the...

  15. FY 2014 Budget Request for the Office of Electricity Delivery...

    Office of Environmental Management (EM)

    4 Budget Request for the Office of Electricity Delivery and Energy Reliability FY 2014 Budget Request for the Office of Electricity Delivery and Energy Reliability Table showing...

  16. Cytometric Therapies for Cell Delivery - Energy Innovation Portal

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Advanced Materials Advanced Materials Find More Like This Return to Search Cytometric Therapies for Cell Delivery Maximizing Efficacy of Cell Delivery Oak Ridge National Laboratory ...

  17. Status and EAC Recommendations for Electricity Delivery Workforce...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Status and EAC Recommendations for Electricity Delivery Workforce (September 2014) Status and EAC Recommendations for Electricity Delivery Workforce (September 2014) This memo, ...

  18. Part IV: Section F - Deliveries or Performance

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    F DELIVERIES OR PERFORMANCE DE-AC36-08GO28308 Modification M933 Section F - Page ii PART I SECTION F DELIVERIES OR PERFORMANCE TABLE OF CONTENT F.1 Term of Contract 1 F.2 Principal Place of Performance 1 F.3 FAR 52.242-15 Stop-Work Order (Aug 1989) (Alternate 1) (Apr 1984) 1 DE-AC36-08GO28308 Modification M933 Section F - Page 1 of 2 PART I SECTION F DELIVERIES OR PERFORMANCE F.1 Term of Contract (a) This contract shall be effective as specified in Block No. 28, Award Date, of SF 33, and shall

  19. Integrated Waste Feed Delivery Plan - Hanford Site

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Documents Integrated Waste Feed Delivery Plan Documents Documents Hanford Site Cleanup Completion Framework Tri-Party Agreement Freedom of Information and Privacy Act Hanford Site Budget Hanford Site Safety Standards DOE - ORP Contracts/Procurements DOE - RL Contracts/Procurements Integrated Waste Feed Delivery Plan Single-Shell Tank Evaluations Deep Vadose Zone 100-F RI/FS 100-D/H Operable Units RI/FS Sitewide Probabilistic Seismic Hazard Analysis Environmental Email Email Page | Print Print

  20. Hydrogen Delivery Scenario Analysis Model (HDSAM)

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Scenario Analysis Model (HDSAM) (Argonne National Laboratory) Objectives Provide platform for comparing the cost of alternative hydrogen delivery and refueling options. Identify cost drivers of current hydrogen delivery and refueling technologies for various market penetrations of fuel cell electric vehicles (FCEVs). Key Attributes & Strengths The tool is highly flexible, allowing end users the ability to change many detailed input assumptions and to perform sensitivity analyses. HDSAM

  1. Final Report - Hydrogen Delivery Infrastructure Options Analysis

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    The Power of Experience Final Report Hydrogen Delivery Infrastructure Options Analysis DOE Award Number: DE-FG36-05GO15032 Project director/principal investigator: Tan-Ping Chen Consortium/teaming Partners: Air Liquide, Chevron Technology Venture, Gas Technology Institute, NREL, Tiax, ANL Hydrogen Delivery Infrastructure Options Analysis ii TABLE OF CONTENTS SECTION 1 EXECUTIVE SUMMARY ........................................................................... 1-1 1.1 HOW THE RESEARCH ADDS TO

  2. Gaseous Hydrogen Delivery | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Delivery Gaseous Hydrogen Delivery Gaseous hydrogen is most commonly delivered either by trucks or through pipelines. Because gaseous hydrogen is typically produced at relatively low pressures (20-30 bar), it must be compressed prior to transport. Learn more about gaseous hydrogen compression. Trucks that haul gaseous hydrogen are called tube trailers. Gaseous hydrogen is compressed to pressures of 180 bar (~2,600 psig) or higher into long cylinders which are stacked on the trailer that the

  3. Quality assurance for online adapted treatment plans: Benchmarking and delivery monitoring simulation

    SciTech Connect (OSTI)

    Li, Taoran Wu, Qiuwen; Yang, Yun; Rodrigues, Anna; Yin, Fang-Fang; Jackie Wu, Q.

    2015-01-15

    Purpose: An important challenge facing online adaptive radiation therapy is the development of feasible and efficient quality assurance (QA). This project aimed to validate the deliverability of online adapted plans and develop a proof-of-concept online delivery monitoring system for online adaptive radiation therapy QA. Methods: The first part of this project benchmarked automatically online adapted prostate treatment plans using traditional portal dosimetry IMRT QA. The portal dosimetry QA results of online adapted plans were compared to original (unadapted) plans as well as randomly selected prostate IMRT plans from our clinic. In the second part, an online delivery monitoring system was designed and validated via a simulated treatment with intentional multileaf collimator (MLC) errors. This system was based on inputs from the dynamic machine information (DMI), which continuously reports actual MLC positions and machine monitor units (MUs) at intervals of 50 ms or less during delivery. Based on the DMI, the system performed two levels of monitoring/verification during the delivery: (1) dynamic monitoring of cumulative fluence errors resulting from leaf position deviations and visualization using fluence error maps (FEMs); and (2) verification of MLC positions against the treatment plan for potential errors in MLC motion and data transfer at each control point. Validation of the online delivery monitoring system was performed by introducing intentional systematic MLC errors (ranging from 0.5 to 2 mm) to the DMI files for both leaf banks. These DMI files were analyzed by the proposed system to evaluate the systems performance in quantifying errors and revealing the source of errors, as well as to understand patterns in the FEMs. In addition, FEMs from 210 actual prostate IMRT beams were analyzed using the proposed system to further validate its ability to catch and identify errors, as well as establish error magnitude baselines for prostate IMRT delivery. Results

  4. NERSC Staff, Users Readying for Delivery of Cori Phase 2 Knights

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Landing-based System in July Staff, Users Readying for Delivery of Cori Phase 2 Knights Landing-based System in July NERSC Staff, Users Readying for Delivery of Cori Phase 2 Knights Landing-based System in July June 20, 2016 Jon Bashor, jbashor@lbl.gov, +1 510.486.5849 Cori2 For the past year, staff at the Department of Energy's National Energy Research Scientific Computing Center (NERSC) have been preparing users of 20 leading science applications for the arrival of the second phase of its

  5. Research Plan: Foam Delivery of Remedial Amendments to Deep Vadose Zone for Metals and Radionuclides Remediation

    SciTech Connect (OSTI)

    Zhong, Lirong; Hart, Andrea T.; Szecsody, James E.; Zhang, Z. F.; Freedman, Vicky L.; Ankeny, Mark; Hull, Laurence; Oostrom, Martinus; Freshley, Mark D.; Wellman, Dawn M.

    2009-01-16

    Research proposals were submitted to the Scientific and Technical Basis for In Situ Treatment of Metals and Radionuclides Technical Working Group under the US Department of Energy (DOE) Environmental Management Office (specifically, EM-22). After a peer review and selection process, the proposal, “Foam Delivery of Remedial Amendments to Deep Vadose Zone for Metals and Radionuclides Remediation,” submitted by Pacific Northwest National Laboratory (PNNL) was selected for support by the program. A research plan was requested for this EM funded project. The overall objective of this project is to develop foam delivery technology for the distribution of remedial amendments to deep vadose zone sediments for in situ immobilization of metal and radionuclide contaminants. The focus of this research in FY 2009 is on the physical aspects of the foam delivery approach. Specific objectives are to 1) study the foam quality (i.e. the gas volume fraction in foam) influence on injection pressure, 2) study the sediment air permeability influence on injection pressure, 3) investigate liquid uptake in sediment and determine whether a water front will be formed during foam delivery, 4) test amendment distance (and mass) delivery by foam from the injection point, 5) study the enhanced sweeping over heterogeneous systems (i.e., low K zones) by foam delivery relative to water-based delivery under vadose zone conditions, and 6) numerically simulate foam delivery processes in the vadose zone. Laboratory scale experiments will be conducted at PNNL to study a range of basic physical aspects of the foam propagation in sediments, including foam quality and sediment permeability influence on injection pressure, liquid uptake, and foam sweeping across heterogeneous systems. This study will be augmented with separate studies to be conducted at MSE Technology Applications, Inc. (MSE) to evaluate foam transport and amendment delivery at the intermediate-scale. The results of intermediate

  6. Joint Meeting on Hydrogen Delivery Modeling and Analysis Meeting Agenda |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Agenda Joint Meeting on Hydrogen Delivery Modeling and Analysis Meeting Agenda Agenda for the Joint Meeting on Hydrogen Delivery Modeling and Analysis, May 8-9, 2007 deliv_analysis_agenda.pdf (77.66 KB) More Documents & Publications Hydrogen Delivery Analysis Models Hydrogen Delivery Analysis Plus Meeting: DTT, STT, HPTT, Other Analysts, Invited Guests Joint Meeting on Hydrogen Delivery Modeling and Analysis Meeting Attendees List

  7. Improvements to Hydrogen Delivery Scenario Analysis Model (HDSAM) and

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Results | Department of Energy Improvements to Hydrogen Delivery Scenario Analysis Model (HDSAM) and Results Improvements to Hydrogen Delivery Scenario Analysis Model (HDSAM) and Results This presentation by Amgad Elgowainy of Argonne National Laboratory was given at the Joint Meeting on Hydrogen Delivery Modeling and Analysis, May 8-9, 2007. deliv_analysis_elgowainy.pdf (449.02 KB) More Documents & Publications Hydrogen Delivery Analysis Models H2A Delivery Scenario Model and Analyses

  8. THE HANFORD WASTE FEED DELIVERY OPERATIONS RESEARCH MODEL

    SciTech Connect (OSTI)

    BERRY J; GALLAHER BN

    2011-01-13

    Washington River Protection Solutions (WRPS), the Hanford tank farm contractor, is tasked with the long term planning of the cleanup mission. Cleanup plans do not explicitly reflect the mission effects associated with tank farm operating equipment failures. EnergySolutions, a subcontractor to WRPS has developed, in conjunction with WRPS tank farms staff, an Operations Research (OR) model to assess and identify areas to improve the performance of the Waste Feed Delivery Systems. This paper provides an example of how OR modeling can be used to help identify and mitigate operational risks at the Hanford tank farms.

  9. Publications | Energy Systems Integration | NREL

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Transactions on Power Delivery Photovoltaic Inverter Controllers Seeking AC Optimal Power Flow Solutions, IEEE Transactions on Power Systems Slow Dynamics Model of Compressed ...

  10. Cryocompressed Hydrogen Storage and Liquid Delivery

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Cryocompressed Hydrogen Storage & Liquid Delivery Jacob Leachman, Ph.D. Assistant Professor DOE H 2 Transmission & Delivery Workshop 2/26/2014 H Y P E R H drogen roperties for nergy esearch This presentation does not contain any proprietary, confidential, or otherwise restricted information. Jacob Leachman * DOE H 2 Transmission & Distribution Workshop * 2/25/2014 H Y P E R Why Cryogenic Hydrogen? * LH 2 tanker trucks delivered 80-90 % of total small merchant H 2 in 2010. 1 * Cryo-H

  11. Common Cyber Security Vulnerabilities Observed in Control System...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Systems (September 2011) Vulnerability Analysis of Energy Delivery Control Systems - 2011 Lessons Learned from Cyber Security Assessments of SCADA and Energy Management Systems

  12. Systematic adaptation of data delivery

    DOE Patents [OSTI]

    Bakken, David Edward

    2016-02-02

    This disclosure describes, in part, a system management component for use in a power grid data network to systematically adjust the quality of service of data published by publishers and subscribed to by subscribers within the network. In one implementation, subscribers may identify a desired data rate, a minimum acceptable data rate, desired latency, minimum acceptable latency and a priority for each subscription and the system management component may adjust the data rates in real-time to ensure that the power grid data network does not become overloaded and/or fail. In one example, subscriptions with lower priorities may have their quality of service adjusted before subscriptions with higher priorities. In each instance, the quality of service may be maintained, even if reduced, to meet or exceed the minimum acceptable quality of service for the subscription.

  13. Geek-Up[12.10.2010]: A New Planet in Another Solar System, Fast-Tracked Drug Treatments and Better Batteries

    Energy.gov [DOE]

    Using high-contrast, near infrared adaptive optics on the Keck II telescope in Hawaii, LLNL astronomers have identified a fourth planet that is part of a new planetary system discovered in 2008.

  14. Fuel Cell Technologies Office Multi-Year Research, Development, and Demonstration Plan - Section 3.2 Hydrogen Delivery

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Brayton cycle, and a Joule-Thompson cycle) and are energy intensive, consuming energy in amounts corresponding to ~⅓ of the energy in the hydrogen. 2015 DELIVERY SECTION Multi-Year Research, Development, and Demonstration Plan Page 3.2 - 7 Table 3.2.1 Hydrogen Delivery Infrastructure Components Delivery Component Current Status Gas cooling systems 70-MPa (700-bar) dispensing of gaseous H 2 into Type IV tanks at a fill rate of 1.6 kg/min currently requires pre-cooling of the gas to overcome the

  15. Fuel Cell Technologies Office Multi-Year Research, Development, and Demonstration Plan - Section 3.2 Hydrogen Delivery

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Brayton cycle, and a Joule-Thompson cycle) and are energy intensive, consuming energy in amounts corresponding to ~⅓ of the energy in the hydrogen. 2015 DELIVERY SECTION Multi-Year Research, Development, and Demonstration Plan Page 3.2 - 7 Table 3.2.1 Hydrogen Delivery Infrastructure Components Delivery Component Current Status Gas cooling systems 70-MPa (700-bar) dispensing of gaseous H 2 into Type IV tanks at a fill rate of 1.6 kg/min currently requires pre-cooling of the gas to overcome

  16. Alabama Natural Gas Percentage Total Industrial Deliveries (Percent...

    Gasoline and Diesel Fuel Update

    Industrial Deliveries (Percent) Alabama Natural Gas Percentage Total Industrial Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9...

  17. Air Force Generic In-Kind Consideration Delivery Agreement |...

    Open Energy Information (Open El) [EERE & EIA]

    Delivery Agreement Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- OtherOther: Air Force Generic In-Kind Consideration Delivery AgreementLegal...

  18. Maine Natural Gas Exports (No Intransit Deliveries) (Million...

    U.S. Energy Information Administration (EIA) (indexed site)

    Exports (No Intransit Deliveries) (Million Cubic Feet) Maine Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5...

  19. Maine Natural Gas % of Total Residential Deliveries (Percent...

    Gasoline and Diesel Fuel Update

    % of Total Residential Deliveries (Percent) Maine Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8...

  20. Alternative Fuels Data Center: Natural Gas Delivery Vans Support...

    Alternative Fuels and Advanced Vehicles Data Center

    Natural Gas Delivery Vans Support McShan Florist to someone by E-mail Share Alternative Fuels Data Center: Natural Gas Delivery Vans Support McShan Florist on Facebook Tweet about ...

  1. Alternative Fuels Data Center: Natural Gas Powers Milk Delivery...

    Alternative Fuels and Advanced Vehicles Data Center

    Natural Gas Powers Milk Delivery Trucks in Indiana to someone by E-mail Share Alternative Fuels Data Center: Natural Gas Powers Milk Delivery Trucks in Indiana on Facebook Tweet ...

  2. ,"West Virginia Natural Gas Deliveries to Electric Power Consumers...

    U.S. Energy Information Administration (EIA) (indexed site)

    "Back to Contents","Data 1: West Virginia Natural Gas Deliveries to Electric Power Consumers (MMcf)" "Sourcekey","N3045WV2" "Date","West Virginia Natural Gas Deliveries to ...

  3. DOE to Defer Strategic Petroleum Reserve RIK Deliveries | Department...

    Office of Environmental Management (EM)

    oil that had been scheduled for delivery to the nation's Strategic Petroleum Reserve sites (SPR) this summer. The deferred deliveries are part of a royalty-in-kind crude oil ...

  4. Joint Meeting on Hydrogen Delivery Modeling and Analysis | Department...

    Office of Environmental Management (EM)

    Meeting on Hydrogen Delivery Modeling and Analysis Joint Meeting on Hydrogen Delivery Modeling and Analysis On May 8-9, 2007, the U.S. Department of Energy (DOE) held a meeting to ...

  5. Nevada Natural Gas % of Total Residential Deliveries (Percent...

    Annual Energy Outlook

    Nevada Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 ... Share of Total U.S. Natural Gas Residential Deliveries Nevada Share of Total U.S. Natural ...

  6. Washington Natural Gas % of Total Residential Deliveries (Percent...

    Annual Energy Outlook

    % of Total Residential Deliveries (Percent) Washington Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8...

  7. Texas Natural Gas % of Total Residential Deliveries (Percent...

    Gasoline and Diesel Fuel Update

    Texas Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 ... Share of Total U.S. Natural Gas Residential Deliveries Texas Share of Total U.S. Natural ...

  8. North Carolina Natural Gas % of Total Residential Deliveries...

    Annual Energy Outlook

    % of Total Residential Deliveries (Percent) North Carolina Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7...

  9. Energy-Efficient Melting and Direct Delivery of High Quality...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energy-Efficient Melting and Direct Delivery of High Quality Molten Aluminum Energy-Efficient Melting and Direct Delivery of High Quality Molten Aluminum itmdelivery.pdf (572.12 ...

  10. Virginia Natural Gas % of Total Residential Deliveries (Percent...

    Gasoline and Diesel Fuel Update

    % of Total Residential Deliveries (Percent) Virginia Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8...

  11. Oklahoma Natural Gas % of Total Residential Deliveries (Percent...

    Annual Energy Outlook

    Oklahoma Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 ... Share of Total U.S. Natural Gas Residential Deliveries Oklahoma Share of Total U.S. ...

  12. New York Natural Gas % of Total Residential Deliveries (Percent...

    Annual Energy Outlook

    New York Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 ... Share of Total U.S. Natural Gas Residential Deliveries New York Share of Total U.S. ...

  13. New Mexico Natural Gas % of Total Residential Deliveries (Percent...

    Gasoline and Diesel Fuel Update

    New Mexico Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 ... Share of Total U.S. Natural Gas Residential Deliveries New Mexico Share of Total U.S. ...

  14. New Jersey Natural Gas % of Total Residential Deliveries (Percent...

    Gasoline and Diesel Fuel Update

    New Jersey Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 ... Share of Total U.S. Natural Gas Residential Deliveries New Jersey Share of Total U.S. ...

  15. Kansas Natural Gas % of Total Residential Deliveries (Percent...

    Gasoline and Diesel Fuel Update

    % of Total Residential Deliveries (Percent) Kansas Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8...

  16. Arizona Natural Gas Exports (No Intransit Deliveries) (Million...

    Annual Energy Outlook

    Exports (No Intransit Deliveries) (Million Cubic Feet) Arizona Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5...

  17. Arizona Natural Gas % of Total Residential Deliveries (Percent...

    Annual Energy Outlook

    % of Total Residential Deliveries (Percent) Arizona Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8...

  18. New Hampshire Natural Gas % of Total Residential Deliveries ...

    Gasoline and Diesel Fuel Update

    % of Total Residential Deliveries (Percent) New Hampshire Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 ...

  19. Minnesota Natural Gas % of Total Residential Deliveries (Percent...

    Gasoline and Diesel Fuel Update

    Minnesota Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 ... Share of Total U.S. Natural Gas Residential Deliveries Minnesota Share of Total U.S. ...

  20. Drug Detection Study

    Office of Scientific and Technical Information (OSTI)

    ... cause a person to be identified as using that substance in a workplace drug test. The initial test refers to the screening assay on specimens to eliminate a "negative" result ...

  1. Hydrogen Delivery Options and Issues | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Options and Issues Hydrogen Delivery Options and Issues Presentation by DOE's Mark Paster at the 2010 - 2025 Scenario Analysis for Hydrogen Fuel Cell Vehicles and Infrastructure Meeting on August 9 - 10, 2006 in Washington, D.C. paster_h2_delivery.pdf (855.32 KB) More Documents & Publications DOE and FreedomCAR and Fuels Partnership: Analysis Workshop H2A Delivery Models and Results Hydrogen Delivery Analysis Models

  2. Inexpensive Delivery of Compressed Hydrogen with Advanced Vessel Technology

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    | Department of Energy Inexpensive Delivery of Compressed Hydrogen with Advanced Vessel Technology Inexpensive Delivery of Compressed Hydrogen with Advanced Vessel Technology Presentation on inexpensive delivery of compressed hydrogen with advanced vessel technology. wkshp_storage_berry.pdf (367.52 KB) More Documents & Publications Overview of FreedomCAR & Fuels Partnership/DOE Delivery Program President's Hydrogen Fuel Initiative High-Pressure Tube Trailers and Tanks

  3. Categorical Exclusion Determinations: Office of Electricity Delivery and

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energy Reliability | Department of Energy Electricity Delivery and Energy Reliability Categorical Exclusion Determinations: Office of Electricity Delivery and Energy Reliability Categorical Exclusion Determinations issued by Electricity Delivery and Energy Reliability. DOCUMENTS AVAILABLE FOR DOWNLOAD March 18, 2015 CX-013479: Categorical Exclusion Determination Frontera Marketing, LLC CX(s) Applied: B4.2 Date: 03/18/2015 Location(s): None Provided Offices(s): Electricity Delivery and Energy

  4. 2012 Annual Planning Summary for Electricity Delivery and Energy Reliability

    Energy.gov [DOE]

    The ongoing and projected Environmental Assessments and Environmental Impact Statements for 2012 and 2013 within Electricity Delivery and Energy Reliability.

  5. Agenda for the Hydrogen Delivery and Onboard Storage Analysis Workshop |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Hydrogen Delivery and Onboard Storage Analysis Workshop Agenda for the Hydrogen Delivery and Onboard Storage Analysis Workshop Agenda for the Hydrogen Delivery and Onboard Storage Analysis workshop. wkshp_storage_agenda.pdf (21.87 KB) More Documents & Publications DOE and FreedomCAR and Fuels Partnership: Analysis Workshop DOE and FreedomCAR and Fuel Partnership Analysis Workshop Joint Meeting on Hydrogen Delivery Modeling and Analysis Meeting Agenda

  6. DOE Technical Targets for Hydrogen Delivery | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Delivery DOE Technical Targets for Hydrogen Delivery These tables summarize the U.S. Department of Energy (DOE) cost and performance targets for major hydrogen delivery process technologies: pressurized containment (for stationary and transport operations), pressurization (compression and pumping), and liquefaction. More information about targets can be found in the Hydrogen Delivery section of the Fuel Cell Technologies Office's Multi-Year Research, Development, and Demonstration Plan. Cost

  7. US DRIVE Hydrogen Delivery Technical Team Roadmap | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Delivery Technical Team Roadmap US DRIVE Hydrogen Delivery Technical Team Roadmap The mission of the Hydrogen Delivery Technical Team (HDTT) is to enable the development of hydrogen delivery technologies, which will allow for fuel cell competitiveness with gasoline and hybrid technologies by achieving an as-produced, delivered, and dispensed hydrogen cost of $2-$4 per gallon of gasoline equivalent of hydrogen. hdtt_roadmap_june2013.pdf (1.55 MB) More Documents & Publications Hydrogen

  8. H2A Delivery Scenario Model and Analyses

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    H2A Delivery Scenario Model and Analyses Marianne Mintz and Jerry Gillette DOE Hydrogen Delivery Analysis and High Pressure Tanks R&D Project Review Meeting February 8, 2005 2 Pioneering Science and Technology Office of Science U.S. Department of Energy Topics * Delivery Scenarios - Current status - Future scenarios * Delivery Scenarios model - Approach - Structure - Current status - Results * Pipeline modeling - Approach - Key assumptions - Results * Next Steps 3 Pioneering Science and

  9. MO-G-BRE-04: Automatic Verification of Daily Treatment Deliveries and Generation of Daily Treatment Reports for a MR Image-Guided Treatment Machine

    SciTech Connect (OSTI)

    Yang, D; Li, X; Li, H; Wooten, H; Green, O; Rodriguez, V; Mutic, S

    2014-06-15

    Purpose: Two aims of this work were to develop a method to automatically verify treatment delivery accuracy immediately after patient treatment and to develop a comprehensive daily treatment report to provide all required information for daily MR-IGRT review. Methods: After systematically analyzing the requirements for treatment delivery verification and understanding the available information from a novel MR-IGRT treatment machine, we designed a method to use 1) treatment plan files, 2) delivery log files, and 3) dosimetric calibration information to verify the accuracy and completeness of daily treatment deliveries. The method verifies the correctness of delivered treatment plans and beams, beam segments, and for each segment, the beam-on time and MLC leaf positions. Composite primary fluence maps are calculated from the MLC leaf positions and the beam-on time. Error statistics are calculated on the fluence difference maps between the plan and the delivery. We also designed the daily treatment delivery report by including all required information for MR-IGRT and physics weekly review - the plan and treatment fraction information, dose verification information, daily patient setup screen captures, and the treatment delivery verification results. Results: The parameters in the log files (e.g. MLC positions) were independently verified and deemed accurate and trustable. A computer program was developed to implement the automatic delivery verification and daily report generation. The program was tested and clinically commissioned with sufficient IMRT and 3D treatment delivery data. The final version has been integrated into a commercial MR-IGRT treatment delivery system. Conclusion: A method was developed to automatically verify MR-IGRT treatment deliveries and generate daily treatment reports. Already in clinical use since December 2013, the system is able to facilitate delivery error detection, and expedite physician daily IGRT review and physicist weekly chart

  10. Cryogenics for superconductors: Refrigeration, delivery, and preservation of the cold

    SciTech Connect (OSTI)

    Venkatarao Ganni, James Fesmire

    2012-06-01

    Applications in superconductivity have become widespread, enabled by advancements in cryogenic engineering. In this paper, the history of cryogenic refrigeration, its delivery, its preservation and the important scientific and engineering advancements in these areas in the last 100 years will be reviewed, beginning with small laboratory dewars to very large scale systems. The key technological advancements in these areas that enabled the development of superconducting applications at temperatures from 4 to 77 K are identified. Included are advancements in the components used up to the present state-of-the-art in refrigeration systems design. Viewpoints as both an equipment supplier and the end-user with regard to the equipment design and operations will be presented. Some of the present and future challenges in these areas will be outlined. Most of the materials in this paper are a collection of the historical materials applicable to these areas of interest.

  11. Waste feed delivery environmental permits and approvals plan

    SciTech Connect (OSTI)

    Papp, I.G.

    1998-07-06

    This document describes the range of environmental actions, including required permits and other agency approvals, that may affect waste feed delivery (WFD) activities in the Hanford Site`s Tank Waste Remediation System (TWRS). This plan expands on the summary level information in the Tank Waste Remediation System Environmental Program Plan (HNF 1773) to address requirements that are most pertinent to WFD. This plan outlines alternative approaches to satisfying applicable environmental standards, and describes selected strategies for acquiring permits and other approvals needed for WFD to proceed. Appendices at the end of this plan provide preliminary cost and schedule estimates for implementing the selected strategies. The rest of this section summarizes the scope of WFD activities, including important TWRS operating information, and describes in more detail the objectives, structure, and content of this plan.

  12. Review Guidance for the TWRS FSAR amendment for Waste Retrieval and waste feed delivery

    SciTech Connect (OSTI)

    GRIFFITH, R.W.

    1999-10-01

    This review guidance (Guide) was developed for Office of River Protection (ORP) reviewers to use in reviewing the amendment to the Tank Waste Remediation System (TWRS) Final Safety Analysis Report (FSAR) covering waste retrieval and waste feed delivery. Waste retrieval and waste feed delivery are necessary to supply nuclear waste from TWRS storage tanks to the TWRS Privatization (TWRS-P) Contractor's vitrification facility and to receive intermediate waste from the vitrification facility back into the TWRS tank farms for interim storage. An amendment to the approved TWRS FSAR (HNF-SD-WM-SAR-067, Rev. 0) is necessary to change the authorization basis to accommodate waste retrieval and waste feed delivery. The ORP'S safety responsibility in reviewing the FSAR amendment is to determine that reasonable assurance exists that waste retrieval and waste feed delivery operations can be accomplished with adequate safety for the workers, the public, and the environment. To carry out this responsibility, the ORP will evaluate the Contractor's amendment to the TWRS FSAR for waste retrieval and waste feed delivery to determine whether the submittal provides adequate safety and complies with applicable regulatory requirements.

  13. Materials Solutions for Hydrogen Delivery in Pipelines

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    OAK RIDGE NATIONAL LABORATORY U.S. DEPARTMENT OF ENERGY Materials Solutions for Hydrogen Delivery in Pipelines Dr. Subodh K. Das SECAT Inc. This presentation does not contain any proprietary or confidential information 2 OAK RIDGE NATIONAL LABORATORY U.S. DEPARTMENT OF ENERGY Overview * Project start date: 05/2005 * Project end date: 09/2008 * Percent complete: 14% Barriers addressed High capital cost and Hydrogen Embrittlement of Pipelines Technical Targets (2015): - Capital cost ($0.8

  14. Materials Solutions for Hydrogen Delivery in Pipelines

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Solutions for Hydrogen Delivery in Pipelines Dr. Subodh K. Das Secat, Inc. September 26, 2007 This presentation does not contain any proprietary, confidential, or otherwise restricted information Project Team SECAT (KY) Project Manager Oregon Steel Mills (OR) Steel Pipe Producer Columbia Gas of Kentucky (KY) NG transporter Schott North America (PA) Glass coatings supplier Chemical Composite Coatings (GA) Composites coatings Advanced Technology Corp. (TN) ABI technology provider ASME (NY) Codes

  15. Solid source MOCVD system

    DOE Patents [OSTI]

    Hubert, Brian N. (Yakima, WA); Wu, Xin Di (San Jose, CA)

    1998-01-01

    A system for MOCVD fabrication of superconducting and non-superconducting oxide films provides a delivery system for the feeding of metalorganic precursors for multi-component chemical vapor deposition. The delivery system can include multiple cartridges containing tightly packed precursor materials. The contents of each cartridge can be ground at a desired rate and fed together with precursor materials from other cartridges to a vaporization zone and then to a reaction zone within a deposition chamber for thin film deposition.

  16. Solid source MOCVD system

    DOE Patents [OSTI]

    Hubert, B.N.; Wu, X.D.

    1998-10-13

    A system for MOCVD fabrication of superconducting and non-superconducting oxide films provides a delivery system for the feeding of metallorganic precursors for multi-component chemical vapor deposition. The delivery system can include multiple cartridges containing tightly packed precursor materials. The contents of each cartridge can be ground at a desired rate and fed together with precursor materials from other cartridges to a vaporization zone and then to a reaction zone within a deposition chamber for thin film deposition. 13 figs.

  17. Water-soluble carbon nanotube compositions for drug delivery and medicinal applications

    DOE Patents [OSTI]

    Tour, James M.; Lucente-Schultz, Rebecca; Leonard, Ashley; Kosynkin, Dmitry V.; Price, Brandi Katherine; Hudson, Jared L.; Conyers, Jr., Jodie L.; Moore, Valerie C.; Casscells, S. Ward; Myers, Jeffrey N.; Milas, Zvonimir L.; Mason, Kathy A.; Milas, Luka

    2014-07-22

    Compositions comprising a plurality of functionalized carbon nanotubes and at least one type of payload molecule are provided herein. The compositions are soluble in water and PBS in some embodiments. In certain embodiments, the payload molecules are insoluble in water. Methods are described for making the compositions and administering the compositions. An extended release formulation for paclitaxel utilizing functionalized carbon nanotubes is also described.

  18. Apoferritin-based nanomedicine platform for drug delivery: equilibrium binding study of daunomycin with DNA

    SciTech Connect (OSTI)

    Ma Ham, Aihui; Wu, Hong J.; Wang, Jun; Kang, Xinhuang; Zhang, Youyu; Lin, Yuehe

    2011-05-11

    Apoferritin is a nanostructured material with a uniform size and spherical structure, and it has excellent bio-compatibility. In this work, we report the use of apoferritin as a novel and biocompatible carrier for stabilizing enzymes and their activities. We used glucose oxidase (GOx) as a model enzyme. GOx was immobilized on the surface of the apoferritin through a green synthetic approach taking advantage of bioaffinity binding between streptavidin and biotin. As a result, a glucose oxidase-biotin/streptavidin/biotin-apoferritin conjugate (Apo-GOx) was prepared using streptavidin as a bridge. The synthesized Apo-GOx was characterized with transmission electron microscopy, ultraviolet, and fluorescence spectroscopy. The activity and stability of GOx on the surface of the apoferritin were studied in different environments, such as temperature, chemicals, and pH, in comparison with the biotinylated GOx (B-GOx). The results showed that the activity of GOx on the apoferritin surface was significantly enhanced. The thermal and chemical stability of the GOx on the apoferritin was also greatly improved compared to free B-GOx in a solution. It was found that the activity of the GOx on the apoferritin only lost 30% in comparison to a 70% loss of free B-GOx after a 2-hr incubation at 50oC. There was almost no decrease in activity for the GOx on the apoferritin as compared to an 80% activity decrease for free B-GOx after 30 minutes of incubation in a 5 M urea solution. The GOx immobilized apoferritin nanoparticles exhibited high sensitivity for glucose detection with a detection limit of 3 nM glucose. This work offers a novel approach for immobilizing enzymes with enhanced stability and activity, and this method may find a number of applications, such as in catalysis and bioassys/biosensors.

  19. Exploring the Limits of Methane Storage and Delivery in Nanoporous Materials

    SciTech Connect (OSTI)

    Gomez-Gualdron, DA; Wilmer, CE; Farha, OK; Hupp, JT; Snurr, RQ

    2014-04-03

    The physical limits for methane storage and delivery in nanoporous materials were investigated, with a focus on whether it is possible to reach a methane deliverable capacity of 315 cm(3)(STP)/cm(3) in line with the adsorption target established by the ARPA-E agency. Our efforts focused on how both geometric and chemical properties, such as void fraction (V-f), volumetric surface area (S-v), and heat of adsorption (Q(st)), impact methane deliverable capacity, i.e., the amount of methane adsorbed at some storage pressure minus the amount adsorbed at the delivery pressure. With the aid of grand canonical Monte Carlo (GCMC) simulations, we studied methane adsorption and delivery properties in a population of 122 835 hypothetical pcu metal organic frameworks (MOFs) and 39 idealized carbon-based porous materials. From the simulation results, we developed an analytical equation that helped us delimit the necessary material properties to reach specific methane deliverable capacity targets. The maximum deliverable capacity between 65 and 5.8 bar among the hypothetical MOFs was 206 cm(3)(STP)/cm(3) at 298 K. We found that artificially increasing the methane MOF interaction strength by increasing the Lennard-Jones e parameters of the MOF atoms by 2- and 4-fold only improved the maximum deliverable capacity up to 223 and 228 cm(3)(STP)/cm(3), respectively. However, the effect on the amount stored at 65 bar was more significant, which suggested another strategy; raising the temperature of the system by 100 K can recover 70% of the methane stranded at the delivery pressure. By increasing the delivery temperature to 398 K, the ARPA-E target was reached by a few hypothetical MOFs with quadrupled e values. This work shows the difficulty in reaching the ARPA-E target but also suggests that a strategy that combines a material with a large volumetric density of sites that interact strongly with methane and raising the delivery temperature can greatly improve the performance of

  20. Hydrogen production and delivery analysis in US markets : cost, energy and greenhouse gas emissions.

    SciTech Connect (OSTI)

    Mintz, M.; Gillette, J.; Elgowainy, A.

    2009-01-01

    Hydrogen production cost conclusions are: (1) Steam Methane Reforming (SMR) is the least-cost production option at current natural gas prices and for initial hydrogen vehicle penetration rates, at high production rates, SMR may not be the least-cost option; (2) Unlike coal and nuclear technologies, the cost of natural gas feedstock is the largest contributor to SMR production cost; (3) Coal- and nuclear-based hydrogen production have significant penalties at small production rates (and benefits at large rates); (4) Nuclear production of hydrogen is likely to have large economies of scale, but because fixed O&M costs are uncertain, the magnitude of these effects may be understated; and (5) Given H2A default assumptions for fuel prices, process efficiencies and labor costs, nuclear-based hydrogen is likely to be more expensive to produce than coal-based hydrogen. Carbon taxes and caps can narrow the gap. Hydrogen delivery cost conclusions are: (1) For smaller urban markets, compressed gas delivery appears most economic, although cost inputs for high-pressure gas trucks are uncertain; (2) For larger urban markets, pipeline delivery is least costly; (3) Distance from hydrogen production plant to city gate may change relative costs (all results shown assume 100 km); (4) Pipeline costs may be reduced with system 'rationalization', primarily reductions in service pipeline mileage; and (5) Liquefier and pipeline capital costs are a hurdle, particularly at small market sizes. Some energy and greenhouse gas Observations: (1) Energy use (per kg of H2) declines slightly with increasing production or delivery rate for most components (unless energy efficiency varies appreciably with scale, e.g., liquefaction); (2) Energy use is a strong function of production technology and delivery mode; (3) GHG emissions reflect the energy efficiency and carbon content of each component in a production-delivery pathway; (4) Coal and natural gas production pathways have high energy consumption

  1. Effect of delivery condition on desorption rate of ZrCo metal hydride bed for fusion fuel cycle

    SciTech Connect (OSTI)

    Kang, H.G.; Yun, S.H.; Chung, D.; Oh, Y.H.; Chang, M.H.; Cho, S.; Chung, H.; Song, K.M.

    2015-03-15

    For the safety of fusion fuel cycle, hydrogen isotope gases including tritium are stored as metal hydride form. To satisfy fueling requirement of fusion machine, rapid delivery from metal hydride bed is one of major factors for the development of tritium storage and delivery system. Desorption from metal hydride depends on the operation scenario by pressure and temperature control of the bed. The effect of operation scenario and pump performance on desorption rate of metal hydride bed was experimentally investigated using ZrCo bed. The results showed that the condition of pre-heating scenario before actual delivery of gas affected the delivery performance. Different pumps were connected to desorption line from bed and the effect of pump capacity on desorption rate were also found to be significant. (authors)

  2. Evaluation of Nanolipoprotein Particles (NLPs) as an In Vivo Delivery Platform

    SciTech Connect (OSTI)

    Fischer, Nicholas O.; Weilhammer, Dina R.; Dunkle, Alexis; Thomas, Cynthia; Hwang, Mona; Corzett, Michele; Lychak, Cheri; Mayer, Wasima; Urbin, Salustra; Collette, Nicole; Chiun Chang, Jiun; Loots, Gabriela G.; Rasley, Amy; Blanchette, Craig D.; Ceña, Valentin

    2014-03-27

    Nanoparticles hold great promise for the delivery of therapeutics, yet limitations remain with regards to the use of these nanosystems for efficient long-lasting targeted delivery of therapeutics, including imparting functionality to the platform, in vivo stability, drug entrapment efficiency and toxicity. In order to begin to address these limitations, we evaluated the functionality, stability, cytotoxicity, toxicity, immunogenicity and in vivo biodistribution of nanolipoprotein particles (NLPs), which are mimetics of naturally occurring high-density lipoproteins (HDLs). We also found that a wide range of molecules could be reliably conjugated to the NLP, including proteins, single-stranded DNA, and small molecules. The NLP was also found to be relatively stable in complex biological fluids and displayed no cytotoxicity in vitro at doses as high as 320 µg/ml. In addition, we observed that in vivo administration of the NLP daily for 14 consecutive days did not induce significant weight loss or result in lesions on excised organs. Furthermore, the NLPs did not display overt immunogenicity with respect to antibody generation. Finally, the biodistribution of the NLP in vivo was found to be highly dependent on the route of administration, where intranasal administration resulted in prolonged retention in the lung tissue. Though only a select number of NLP compositions were evaluated, the findings of this study suggest that the NLP platform holds promise for use as both a targeted and non-targeted in vivo delivery vehicle for a range of therapeutics.

  3. Drug development and manufacturing

    DOE Patents [OSTI]

    Warner, Benjamin P.; McCleskey, T. Mark; Burrell, Anthony K.

    2015-10-13

    X-ray fluorescence (XRF) spectrometry has been used for detecting binding events and measuring binding selectivities between chemicals and receptors. XRF may also be used for estimating the therapeutic index of a chemical, for estimating the binding selectivity of a chemical versus chemical analogs, for measuring post-translational modifications of proteins, and for drug manufacturing.

  4. Steam distribution and energy delivery optimization using wireless sensors

    SciTech Connect (OSTI)

    Olama, Mohammed M; Allgood, Glenn O; Kuruganti, Phani Teja; Sukumar, Sreenivas R; Djouadi, Seddik M; Lake, Joe E

    2011-01-01

    The Extreme Measurement Communications Center at Oak Ridge National Laboratory (ORNL) explores the deployment of a wireless sensor system with a real-time measurement-based energy efficiency optimization framework in the ORNL campus. With particular focus on the 12-mile long steam distribution network in our campus, we propose an integrated system-level approach to optimize the energy delivery within the steam distribution system. We address the goal of achieving significant energy-saving in steam lines by monitoring and acting on leaking steam valves/traps. Our approach leverages an integrated wireless sensor and real-time monitoring capabilities. We make assessments on the real-time status of the distribution system by mounting acoustic sensors on the steam pipes/traps/valves and observe the state measurements of these sensors. Our assessments are based on analysis of the wireless sensor measurements. We describe Fourier-spectrum based algorithms that interpret acoustic vibration sensor data to characterize flows and classify the steam system status. We are able to present the sensor readings, steam flow, steam trap status and the assessed alerts as an interactive overlay within a web-based Google Earth geographic platform that enables decision makers to take remedial action. We believe our demonstration serves as an instantiation of a platform that extends implementation to include newer modalities to manage water flow, sewage and energy consumption.

  5. Quantitative analysis of beam delivery parameters and treatment process time for proton beam therapy

    SciTech Connect (OSTI)

    Suzuki, Kazumichi; Gillin, Michael T.; Sahoo, Narayan; Zhu, X. Ronald; Lee, Andrew K.; Lippy, Denise

    2011-07-15

    Purpose: To evaluate patient census, equipment clinical availability, maximum daily treatment capacity, use factor for major beam delivery parameters, and treatment process time for actual treatments delivered by proton therapy systems. Methods: The authors have been recording all beam delivery parameters, including delivered dose, energy, range, spread-out Bragg peak widths, gantry angles, and couch angles for every treatment field in an electronic medical record system. We analyzed delivery system downtimes that had been recorded for every equipment failure and associated incidents. These data were used to evaluate the use factor of beam delivery parameters, the size of the patient census, and the equipment clinical availability of the facility. The duration of each treatment session from patient walk-in and to patient walk-out of the treatment room was measured for 82 patients with cancers at various sites. Results: The yearly average equipment clinical availability in the last 3 yrs (June 2007-August 2010) was 97%, which exceeded the target of 95%. Approximately 2200 patients had been treated as of August 2010. The major disease sites were genitourinary (49%), thoracic (25%), central nervous system (22%), and gastrointestinal (2%). Beams have been delivered in approximately 8300 treatment fields. The use factor for six beam delivery parameters was also evaluated. Analysis of the treatment process times indicated that approximately 80% of this time was spent for patient and equipment setup. The other 20% was spent waiting for beam delivery and beam on. The total treatment process time can be expressed by a quadratic polynomial of the number of fields per session. The maximum daily treatment capacity of our facility using the current treatment processes was estimated to be 133 {+-} 35 patients. Conclusions: This analysis shows that the facility has operated at a high performance level and has treated a large number of patients with a variety of diseases. The use

  6. Report of the Production and Delivery Subgroup

    SciTech Connect (OSTI)

    Glass, R; Zalesky, R

    2004-11-01

    The Production and Delivery Subgroup was tasked with evaluating the various options that could be used for hydrogen production and delivery in terms of availability/industry readiness, technical and economic barriers, and environmental considerations. Hydrogen can be produced using a variety of feedstocks and conversion technologies. The feedstock options include water, natural gas, coal, petroleum, methanol, ethanol, biomass, and organic waste streams. Ultimately, using these domestic resources we will be able to produce all the hydrogen we will need for the complete conversion of our transportation infrastructure. The various conversion technologies include electrolysis, reforming (principally of natural gas, but also ethanol and methanol), photobiological and photoelectrochemical, biofermentation, pyrolysis and gasification of biomass and coal, high temperature thermochemical, and catalytic membranes. All of these production technologies are being actively researched by DOE's Office of Hydrogen, Fuel Cells and Infrastructure Technologies (HFCIT); and other offices within DOE support work that complements the HFCIT Program activities. In addition, private industry is also dedicating significant resources to these efforts. In establishing the California Hydrogen Highway Network (CA H2 Net) we must utilize both distributed (that is, hydrogen that is produced at the point of use) as well as centralized production of hydrogen. Because of technical and economic barriers, most of the technologies for hydrogen production listed above will not become practical for either mode of hydrogen production in large quantities until at least the 2015-2030 timeframe. In the near term, that is, the transitional period between now and 2010 when we will establish a widely available hydrogen fueling infrastructure in California, the distributed production options of reforming and electrolysis will play the dominant role. In addition, production of hydrogen at centralized plants using

  7. WE-D-BRD-01: Innovation in Radiation Therapy Delivery: Advanced Digital Linac Features

    SciTech Connect (OSTI)

    Xing, L; Wong, J; Li, R

    2014-06-15

    Last few years has witnessed significant advances in linac technology and therapeutic dose delivery method. Digital linacs equipped with high dose rate FFF beams have been clinically implemented in a number of hospitals. Gated VMAT is becoming increasingly popular in treating tumors affected by respiratory motion. This session is devoted to update the audience with these technical advances and to present our experience in clinically implementing the new linacs and dose delivery methods. Topics to be covered include, technical features of new generation of linacs from different vendors, dosimetric characteristics and clinical need for FFF-beam based IMRT and VMAT, respiration-gated VMAT, the concept and implementation of station parameter optimized radiation therapy (SPORT), beam level imaging and onboard image guidance tools. Emphasis will be on providing fundamental understanding of the new treatment delivery and image guidance strategies, control systems, and the associated dosimetric characteristics. Commissioning and acceptance experience on these new treatment delivery technologies will be reported. Clinical experience and challenges encountered during the process of implementation of the new treatment techniques and future applications of the systems will also be highlighted. Learning Objectives: Present background knowledge of emerging digital linacs and summarize their key geometric and dosimetric features. SPORT as an emerging radiation therapy modality specifically designed to take advantage of digital linacs. Discuss issues related to the acceptance and commissioning of the digital linacs and FFF beams. Describe clinical utility of the new generation of digital linacs and their future applications.

  8. Fuel Cell Technologies Program: Delivery Fact Sheet

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Distribution and Delivery Most of the hydrogen used in the U.S. is produced at or near where it is used - typically at large industrial sites. As a result, an efficient means of delivering large quantities of hydrogen fuel over long distances and at low cost does not yet exist. Before hydrogen can become a mainstream energy carrier, we must first develop and build the infrastructure (e.g. the miles of transmission and distribu- tion pipelines, bulk storage vessels, and refueling stations) that

  9. Real time sensor for therapeutic radiation delivery

    DOE Patents [OSTI]

    Bliss, Mary; Craig, Richard A.; Reeder, Paul L.

    1998-01-01

    The invention is a real time sensor for therapeutic radiation. A probe is placed in or near the patient that senses in real time the dose at the location of the probe. The strength of the dose is determined by either an insertion or an exit probe. The location is determined by a series of vertical and horizontal sensing elements that gives the operator a real time read out dose location relative to placement of the patient. The increased accuracy prevents serious tissue damage to the patient by preventing overdose or delivery of a dose to a wrong location within the body.

  10. Real time sensor for therapeutic radiation delivery

    DOE Patents [OSTI]

    Bliss, M.; Craig, R.A.; Reeder, P.L.

    1998-01-06

    The invention is a real time sensor for therapeutic radiation. A probe is placed in or near the patient that senses in real time the dose at the location of the probe. The strength of the dose is determined by either an insertion or an exit probe. The location is determined by a series of vertical and horizontal sensing elements that gives the operator a real time read out dose location relative to placement of the patient. The increased accuracy prevents serious tissue damage to the patient by preventing overdose or delivery of a dose to a wrong location within the body. 14 figs.

  11. TIMELY DELIVERY OF LASER INERTIAL FUSION ENERGY (LIFE)

    SciTech Connect (OSTI)

    Dunne, A M

    2010-11-30

    The National Ignition Facility (NIF), the world's largest and most energetic laser system, is now operational at Lawrence Livermore National Laboratory. A key goal of the NIF is to demonstrate fusion ignition for the first time in the laboratory. Its flexibility allows multiple target designs (both indirect and direct drive) to be fielded, offering substantial scope for optimization of a robust target design. In this paper we discuss an approach to generating gigawatt levels of electrical power from a laser-driven source of fusion neutrons based on these demonstration experiments. This 'LIFE' concept enables rapid time-to-market for a commercial power plant, assuming success with ignition and a technology demonstration program that links directly to a facility design and construction project. The LIFE design makes use of recent advances in diode-pumped, solid-state laser technology. It adopts the paradigm of Line Replaceable Units utilized on the NIF to provide high levels of availability and maintainability and mitigate the need for advanced materials development. A demonstration LIFE plant based on these design principles is described, along with the areas of technology development required prior to plant construction. A goal-oriented, evidence-based approach has been proposed to allow LIFE power plant rollout on a time scale that meets policy imperatives and is consistent with utility planning horizons. The system-level delivery builds from our prior national investment over many decades and makes full use of the distributed capability in laser technology, the ubiquity of semiconductor diodes, high volume manufacturing markets, and U.S. capability in fusion science and nuclear engineering. The LIFE approach is based on the ignition evidence emerging from NIF and adopts a line-replaceable unit approach to ensure high plant availability and to allow evolution from available technologies and materials. Utilization of a proven physics platform for the ignition

  12. Joint Meeting on Hydrogen Delivery Modeling and Analysis Meeting Attendees

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    List | Department of Energy Attendees List Joint Meeting on Hydrogen Delivery Modeling and Analysis Meeting Attendees List Attendee list from the Joint Meeting on Hydrogen Delivery Modeling and Analysis, May 8-9, 2007 deliv_analysis_attendees.pdf (77.35 KB) More Documents & Publications DOE and FreedomCAR and Fuel Partnership Analysis Workshop Joint Meeting on Hydrogen Delivery Modeling and Analysis Meeting Agenda DOE and FreedomCAR and Fuel Partnership Analysis Workshop

  13. Percentage of Total Natural Gas Industrial Deliveries included in Prices

    U.S. Energy Information Administration (EIA) (indexed site)

    City Gate Price Residential Price Percentage of Total Residential Deliveries included in Prices Commercial Price Percentage of Total Commercial Deliveries included in Prices Industrial Price Percentage of Total Industrial Deliveries included in Prices Electric Power Price Period: Monthly Annual Download Series History Download Series History Definitions, Sources & Notes Definitions, Sources & Notes Show Data By: Data Series Area Mar-16 Apr-16 May-16 Jun-16 Jul-16 Aug-16 View History U.S.

  14. Percentage of Total Natural Gas Residential Deliveries included in Prices

    U.S. Energy Information Administration (EIA) (indexed site)

    City Gate Price Residential Price Percentage of Total Residential Deliveries included in Prices Commercial Price Percentage of Total Commercial Deliveries included in Prices Industrial Price Percentage of Total Industrial Deliveries included in Prices Electric Power Price Period: Monthly Annual Download Series History Download Series History Definitions, Sources & Notes Definitions, Sources & Notes Show Data By: Data Series Area Mar-16 Apr-16 May-16 Jun-16 Jul-16 Aug-16 View History U.S.

  15. Secretary Chu's Remarks as Prepared for Delivery at the Washington

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    University Commencement | Department of Energy as Prepared for Delivery at the Washington University Commencement Secretary Chu's Remarks as Prepared for Delivery at the Washington University Commencement May 21, 2010 - 12:00am Addthis Remarks of Secretary Steven Chu- As Prepared for Delivery Washington University Friday, May 21, 2010 Chancellor Mark Wrighton, the Board of Trustees, faculty, family, and friends here today, thank you for letting me share this wonderful day with you. It is a

  16. Hydrogen Delivery Analysis Plus Meeting: DTT, STT, HPTT, Other Analysts,

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Invited Guests | Department of Energy Plus Meeting: DTT, STT, HPTT, Other Analysts, Invited Guests Hydrogen Delivery Analysis Plus Meeting: DTT, STT, HPTT, Other Analysts, Invited Guests Presentation at the Joint Meeting on Hydrogen Delivery Modeling and Analysis, May 8-9, 2007 deliv_analysis_paster.pdf (318.86 KB) More Documents & Publications Joint Meeting on Hydrogen Delivery Modeling and Analysis Meeting Agenda DOE and FreedomCAR and Fuels Partnership: Analysis Workshop Joint Meeting

  17. H2A Delivery Models and Results | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Models and Results H2A Delivery Models and Results Presentation on hydrogen analysis delivery models and results prepared for DOE January 25 workshop. wkshp_storage_mintz.pdf (1.89 MB) More Documents & Publications Analysis of a Cluster Strategy for Near Term Hydrogen Infrastructure Rollout in Southern California H2A Delivery Scenario Model and Analyses Hydrogen Supply: Cost Estimate for Hydrogen Pathways-Scoping Analysis. January 22, 2002-July 22, 2002

  18. H2A Hydrogen Delivery Infrastructure Analysis Models and Conventional

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Pathway Options Analysis Results - Interim Report | Department of Energy Delivery Infrastructure Analysis Models and Conventional Pathway Options Analysis Results - Interim Report H2A Hydrogen Delivery Infrastructure Analysis Models and Conventional Pathway Options Analysis Results - Interim Report An in-depth comparative analysis of promising infrastructure options for hydrogen delivery and distribution to refueling stations from central, semi-central, and distributed production facilities.

  19. National Electric Delivery Technologies Roadmap: Transforming the Grid to

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Revolutionize Electric Power in North America | Department of Energy Delivery Technologies Roadmap: Transforming the Grid to Revolutionize Electric Power in North America National Electric Delivery Technologies Roadmap: Transforming the Grid to Revolutionize Electric Power in North America This Roadmap provides a framework for all of the stakeholders that comprise the electric industry to work together to achieve common aims. National Electric Delivery Technologies Roadmap: Transforming the

  20. Office of Electricity Delivery And Energy Reliability To Hold Technical

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Conference On The Design Of Future Electric Transmission | Department of Energy Office of Electricity Delivery And Energy Reliability To Hold Technical Conference On The Design Of Future Electric Transmission Office of Electricity Delivery And Energy Reliability To Hold Technical Conference On The Design Of Future Electric Transmission February 5, 2009 - 10:57am Addthis On March 4, 2009, the Department of Energy's Office of Electricity Delivery and Energy Reliability (OE) will conduct a

  1. H2A Delivery: Miscellaneous Cost and H2 Losses

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Miscellaneous Costs and H2 Losses Hydrogen Delivery Analysis Meeting May 8-9, 2006 Matt Ringer National Renewable Energy Laboratory H2A Delivery Presentation Outline * Direct and Indirect Costs * Operating and Maintenance Costs * Labor Costs and Scaling Factor * Component Hydrogen Losses H2A Delivery Direct and Indirect Costs * Currently posted model includes site preparation, engineering and design, project contingency, one-time licensing fees and permitting - Factor of 1.225 above installed

  2. Cybersecurity for Energy Delivery Systems | Department of Energy

    Energy Savers

    Energy Program Cybersecurity Capability Maturity Model (C2M2) Program Cybersecurity Capability Maturity Model (C2M2) Program The Cybersecurity Capability Maturity Model (C2M2) program is a public-private partnership effort that was established as a result of the Administration's efforts to improve electricity subsector cybersecurity capabilities, and to understand the cybersecurity posture of the grid. The C2M2 helps organizations-regardless of size, type, or industry-evaluate, prioritize,

  3. Roadmap to Achieve Energy Delivery Systems Cybersecurity- 2011

    Office of Energy Efficiency and Renewable Energy (EERE)

    As part of the Obama Administration’s goals to enhance the security and reliability of the Nation’s energy infrastructure, the U.S. Department of Energy released the 2011 Roadmap to Achieve Energy...

  4. HYDROGEN PRODUCTION AND DELIVERY INFRASTRUCTURE AS A COMPLEX ADAPTIVE SYSTEM

    SciTech Connect (OSTI)

    Tolley, George S

    2010-06-29

    An agent-based model of the transition to a hydrogen transportation economy explores influences on adoption of hydrogen vehicles and fueling infrastructure. Attention is given to whether significant penetration occurs and, if so, to the length of time required for it to occur. Estimates are provided of sensitivity to numerical values of model parameters and to effects of alternative market and policy scenarios. The model is applied to the Los Angeles metropolitan area In the benchmark simulation, the prices of hydrogen and non-hydrogen vehicles are comparable. Due to fuel efficiency, hydrogen vehicles have a fuel savings advantage of 9.8 cents per mile over non-hydrogen vehicles. Hydrogen vehicles account for 60% of new vehicle sales in 20 years from the initial entry of hydrogen vehicles into show rooms, going on to 86% in 40 years and reaching still higher values after that. If the fuel savings is 20.7 cents per mile for a hydrogen vehicle, penetration reaches 86% of new car sales by the 20th year. If the fuel savings is 0.5 cents per mile, market penetration reaches only 10% by the 20th year. To turn to vehicle price difference, if a hydrogen vehicle costs $2,000 less than a non-hydrogen vehicle, new car sales penetration reaches 92% by the 20th year. If a hydrogen vehicle costs $6,500 more than a non-hydrogen vehicle, market penetration is only 6% by the 20th year. Results from other sensitivity runs are presented. Policies that could affect hydrogen vehicle adoption are investigated. A tax credit for the purchase of a hydrogen vehicle of $2,500 tax credit results in 88% penetration by the 20th year, as compared with 60% in the benchmark case. If the tax credit is $6,000, penetration is 99% by the 20th year. Under a more modest approach, the tax credit would be available only for the first 10 years. Hydrogen sales penetration then reach 69% of sales by the 20th year with the $2,500 credit and 79% with the $6,000 credit. A carbon tax of $38 per metric ton is not large enough to noticeably affect sales penetration. A tax of $116 per metric ton makes centrally produced hydrogen profitable in the very first year but results in only 64% penetration by year 20 as opposed to the 60% penetration in the benchmark case. Provision of 15 seed stations publicly provided at the beginning of the simulation, in addition to the 15 existing stations in the benchmark case, gives sales penetration rates very close to the benchmark after 20 years, namely, 63% and 59% depending on where they are placed.

  5. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    KB) CEDS 2010 Peer Review - Right-Sized SCADA Communications - Loren Toole & Andy ... - Visualization and Modeling DOEOE National SCADA Test Bed Fiscal Year 2009 Work Plan

  6. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    CEDS 2010 Peer Review - TCIPG Center Overview - William Sanders, Illinois.pdf (830.59 KB) CEDS 2010 Peer Review - Converged Networks for SCADA - Himanshu Khurana, Illinois.pdf ...

  7. Cybersecurity for Energy Delivery Systems (CEDS) Contact Information...

    Energy.gov (indexed) [DOE]

    ... Phase 2: Outreach and Test * Complete laboratory environment setups and test R&D solution * Integrate solution into an active microgrid to test interoperability with additional ...

  8. Refuse derived fuel delivery system and distribution conveyors

    SciTech Connect (OSTI)

    Kaminski, D.J.; Frank, E.A.; Grinsteiner, C.S.

    1987-08-18

    This patent describes an apparatus for supplying comminuted combustible solid waste material from a refuse material supply to a combustion apparatus for use as fuel and wherein the combustion apparatus includes at least two fuel charging means each having a hopper for receiving comminuted combustible solid waste material, and the hoppers being positioned in side-by-side relation.

  9. Rapid cycling medical synchrotron and beam delivery system (Patent...

    Office of Scientific and Technical Information (OSTI)

    A paper copy of this document is also available for sale to the public from the National Technical Information Service, Springfield, VA at www.ntis.gov. A medical synchrotron which ...

  10. Ammonia storage and delivery systems for NOx aftertreatment

    Energy.gov [DOE]

    Poster presenation at the 2007 Diesel Engine-Efficiency & Emissions Research Conference (DEER 2007). 13-16 August, 2007, Detroit, Michigan. Sponsored by the U.S. Department of Energy's (DOE) Office of FreedomCAR and Vehicle Technologies (OFCVT).

  11. The electric delivery system-a complex network of transmission...

    Energy.gov (indexed) [DOE]

    As the grid is being upgraded, it is also being challenged by increased needs to integrate variable renewable energy resources such as solar and wind, the potential growth of ...

  12. Rapid cycling medical synchrotron and beam delivery system (Patent...

    Office of Scientific and Technical Information (OSTI)

    The second function of the combined function magnet is to focus or defocus the ... Country of Publication: United States Language: English Word Cloud More Like This Full Text ...

  13. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Presentations on Visualization and Modeling are below. CEDS 2010 Peer Review - Real-Time Security State Visualization - Philip Craig, PNNL.pdf (4.29 MB) CEDS 2010 Peer Review - ...

  14. Cybersecurity for Energy Delivery Systems 2010 Peer Review Presentatio...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Management - Philip Craig, PNNL.pdf (668.25 KB) CEDS 2010 Peer Review - Implications of DBT on Critical Infrastructure and Homeland Security - Philip Craig & Jeff Dagle, PNNL.pdf ...

  15. Oncor Electric Delivery Company LLC | Open Energy Information

    Open Energy Information (Open El) [EERE & EIA]

    Oncor Electric Delivery Company LLC Abbreviation: Oncor Place: Dallas, Texas Zip: 75202 Service Territory: Texas Phone Number: 1.888.313.6862 ParentHolding Organization: Energy...

  16. Oncor Electric Delivery Company, LLC Smart Grid Demonstration...

    Open Energy Information (Open El) [EERE & EIA]

    Grid Demonstration Project Jump to: navigation, search Project Lead Oncor Electric Delivery Company, LLC Country United States Headquarters Location Dallas, Texas Recovery Act...

  17. Oncor Electric Delivery - Commercial and Industrial Rebate Program...

    Energy.gov (indexed) [DOE]

    Contact Oncor Program Info Sector Name Utility Administrator Oncor Electric Delivery Website http:www.takealoadofftexas.comindex.aspx?idcommercial-standard-offer...

  18. ,"Maine Natural Gas Exports (No Intransit Deliveries) (Million...

    U.S. Energy Information Administration (EIA) (indexed site)

    ,"Worksheet Name","Description"," Of Series","Frequency","Latest Data for" ,"Data 1","Maine Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet)",1,"Annual",2014...

  19. Natural Gas Deliveries to Commercial Consumers (Including Vehicle...

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    California (Million Cubic Feet) Natural Gas Deliveries to Commercial Consumers (Including Vehicle Fuel through 1996) in California (Million Cubic Feet) Year Jan Feb Mar Apr May Jun ...

  20. Lighting and Electrical Team Leadership and Project Delivery...

    Energy.gov (indexed) [DOE]

    DOE Technology Manager: Kristen Taddonio Presenter: Linda Sandahl, Pacific Northwest National Laboratory Learn More Lighting and Electrical Team Leadership and Project Delivery - ...

  1. Liquid Hydrogen Production and Delivery from a Dedicated Wind...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Liquid Hydrogen Production and Delivery from a Dedicated Wind Power Plant Amgad Elgowainy and Marianne Mintz, Argonne National Laboratory Darlene Steward and Olga Antonia, NREL ...

  2. Hydrogen Delivery Analysis Plus Meeting: DTT, STT, HPTT, Other...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Plus Meeting: DTT, STT, HPTT, Other Analysts, Invited Guests Hydrogen Delivery Analysis Plus Meeting: DTT, STT, HPTT, Other Analysts, Invited Guests Presentation at the Joint...

  3. H2A Delivery: Forecourt Compression & Storage Optimization (Part II)

    Energy.gov [DOE]

    Presentation by Matthew Hooks of TIAX at the Joint Meeting on Hydrogen Delivery Modeling and Analysis, May 8-9, 2007

  4. Natural Gas Deliveries to Commercial Consumers (Including Vehicle...

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Virginia (Million Cubic Feet) Natural Gas Deliveries to Commercial Consumers (Including Vehicle Fuel through 1996) in Virginia (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul...

  5. Streamline Service Delivery via Customer Communication and Contractor Coordination

    Energy.gov [DOE]

    Better Buildings Neighborhood Program Workforce Peer Exchange Call: Streamlining Service Delivery from the Customer’s Perspective, Call Slides and Discussion Summary, August 30, 2012.

  6. Office of Electricity Delivery and Energy Reliability Cyber Security...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Office of Electricity Delivery and Energy Reliability Cyber Security Project Selections On September 23, 2010, speaking at the inaugural GridWise Global Forum, U.S. Energy ...

  7. Vectren Energy Delivery of Indiana (Electric)- Commercial New Construction Rebates

    Office of Energy Efficiency and Renewable Energy (EERE)

    Vectren Energy Delivery offers commercial customers in Indiana electric rebates for the installation of certain types of equipment in newly constructed buildings through its Energy Design Assist...

  8. DOE Office of Electricity Delivery & Energy Reliability (OE)...

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Delivery & Energy Reliability (OE) Energy Storage Safety Workshop - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & ...

  9. Office of Electricity Delivery & Energy Reliability FY 2012 Budget...

    Energy Savers

    recovery enable sources Office of Electricity Delivery and Energy Reliability recovery, the transition to renewable energy sources, and achieve the President's clean energy goals. ...

  10. Streamline Service Delivery via Customer Communication and Contractor...

    Energy.gov (indexed) [DOE]

    Neighborhood Program Workforce Peer Exchange Call: Streamlining Service Delivery from the Customer's Perspective, Call Slides and Discussion Summary, August 30, 2012. Call Slides ...

  11. Hydrogen Fuel-Cell Electric Hybrid Truck & Zero Emission Delivery...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    DOE Vehicle Technologies Office Review Hydrogen Fuel-Cell Electric Hybrid Truck & Zero Emission Delivery Vehicle Deployment Andrew DeCandis (P.I.) - Senior Air Quality Planner ...

  12. Vehicle Technologies Office - AVTA: All Electric Delivery Trucks...

    Energy.gov (indexed) [DOE]

    Smith Newton all-electric delivery trucks in a variety of fleets. This research was conducted by the National Renewable Energy Laboratory (NREL). Smith Newton Vehicle Performance ...

  13. Percentage of Total Natural Gas Industrial Deliveries included...

    Gasoline and Diesel Fuel Update

    Price Percentage of Total Industrial Deliveries included in Prices Vehicle Fuel Price Electric Power Price Period: Monthly Annual Download Series History Download Series ...

  14. Vehicle Technologies Office - AVTA: Hybrid-Electric Delivery...

    Energy.gov (indexed) [DOE]

    Delivery Vehicles (4.63 MB) More Documents & Publications Vehicle Technologies Office - AVTA: Hybrid-Electric Tractor Vehicles Medium and Heavy-Duty Vehicle Field Evaluations ...

  15. United Parcel Service Evaluates Hybrid Electric Delivery Vans...

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    ... United Parcel Service Evaluates Hybrid Electric Delivery Vans Advanced Vehicle Testing This project is part of a series of evaluations performed by NREL's Fleet Test and Evaluation ...

  16. UNITED STATES DEPARTMENT OF ENERGY OFFICE OF ELECTRICITY DELIVERY...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ("RFI") issued by the Office of Electricity Delivery and Energy Reliability ... formed in 2006 to promote investment in electric transmission through development and ...

  17. New York Natural Gas Exports (No Intransit Deliveries) (Million...

    Gasoline and Diesel Fuel Update

    No Intransit Deliveries) (Million Cubic Feet) New York Natural Gas Exports (No Intransit ... Referring Pages: Natural Gas Exports (Summary) New York U.S. Natural Gas Imports & Exports ...

  18. Office of Electricity Delivery & Energy Reliability FY 2012 Budget...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    & Energy Reliability FY 2012 Budget Request Presentation Presentation by Patricia Hoffman of the Office of Electricity Delivery & Energy Reliability FY 2012 Budget Request....

  19. Examination of Terminal Land Requirements for Hydrogen Delivery

    Energy.gov [DOE]

    Presentation by Jerry Gillette of Argonne National Laboratory at the Joint Meeting on Hydrogen Delivery Modeling and Analysis, May 8-9, 2007

  20. Energy Infrastructure Office of Electricity Delivery and Energy...

    Energy.gov (indexed) [DOE]

    Comparing the Impacts of Northeast Hurricanes on Energy Infrastructure Office of Electricity Delivery and Energy Reliability U.S. Department of Energy April 2013 i For Further ...

  1. Massachusetts Save Energy Now-State, Local, and Regional Delivery...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    for the state, local, and regional delivery of its Save Energy Now program, focusing to reducing energy intensity in Connecticut, Massachusetts, New Hampshire, and Rhode Island. ...

  2. Vectren Energy Delivery of Indiana (Gas) - Commercial Energy...

    Energy.gov (indexed) [DOE]

    350 Programmable Thermostat: 20 Commercial Kitchen Equipment: Varies Summary Vectren Energy Delivery offers commercial natural gas customers in Indiana rebates for the...

  3. DRUG TESING PANEL & CUTOFF CONCENTRATIONS

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    DRUG TESTING PANEL & CUTOFF CONCENTRATIONS Initial Test Analyte Initial Test Cutoff Concentration Confirmatory Test Analyte Confirmatory Test Cutoff Concentration Marijuana ...

  4. Neutron crystallography aids drug design

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Neutron crystallography aids drug design Neutron crystallography aids drug design Researchers have used neutron crystallography for the first time to determine the structure of a clinical drug in complex with its human target enzyme. October 9, 2012 Rich Marquez The Protein Crystallography Station at the Los Alamos Neutron Science Center, where groundbreaking work in new drug-design methods is underway using neutron diffraction techniques. Contact Nancy Ambrosiano Communications Office (505)

  5. INTERGRATED-DRUG-TESTING-SYSTEM.pdf

    Energy Savers

    INTERACTIVE: How Much Carbon Do Countries Emit? INTERACTIVE: How Much Carbon Do Countries Emit? December 7, 2015 - 4:41pm Addthis This interactive map is not viewable in your browser. Please view it in a modern browser. If you are using IE9, you can also view the interactive here Daniel Wood Daniel Wood Data Visualization and Cartographic Specialist, Office of Public Affairs Carly Wilkins Carly Wilkins Multimedia Designer KEY FACTS New interactive lets you compare annual carbon emissions of U.S.

  6. Quality control procedures for dynamic treatment delivery techniques involving couch motion

    SciTech Connect (OSTI)

    Yu, Victoria Y.; Fahimian, Benjamin P.; Xing, Lei; Hristov, Dimitre H.

    2014-08-15

    In this study, the authors introduce and demonstrate quality control procedures for evaluating the geometric and dosimetric fidelity of dynamic treatment delivery techniques involving treatment couch motion synchronous with gantry and multileaf collimator (MLC). Tests were designed to evaluate positional accuracy, velocity constancy and accuracy for dynamic couch motion under a realistic weight load. A test evaluating the geometric accuracy of the system in delivering treatments over complex dynamic trajectories was also devised. Custom XML scripts that control the Varian TrueBeam STx (Serial #3) axes in Developer Mode were written to implement the delivery sequences for the tests. Delivered dose patterns were captured with radiographic film or the electronic portal imaging device. The couch translational accuracy in dynamic treatment mode was 0.01 cm. Rotational accuracy was within 0.3, with 0.04 cm displacement of the rotational axis. Dose intensity profiles capturing the velocity constancy and accuracy for translations and rotation exhibited standard deviation and maximum deviations below 3%. For complex delivery involving MLC and couch motions, the overall translational accuracy for reproducing programmed patterns was within 0.06 cm. The authors conclude that in Developer Mode, TrueBeam is capable of delivering dynamic treatment delivery techniques involving couch motion with good geometric and dosimetric fidelity.

  7. Eighteen-Month Final Evaluation of UPS Second Generation Diesel Hybrid-Electric Delivery Vans

    SciTech Connect (OSTI)

    Lammert, M.; Walkowicz, K.

    2012-09-01

    A parallel hybrid-electric diesel delivery van propulsion system was evaluated at a UPS facility in Minneapolis using on-vehicle data logging, fueling, and maintenance records. Route and drive cycle analysis showed different duty cycles for hybrid vs. conventional delivery vans; routes were switched between the study groups to provide a valid comparison. The hybrids demonstrated greater advantage on the more urban routes; the initial conventional vans' routes had less dense delivery zones. The fuel economy of the hybrids on the original conventional group?s routes was 10.4 mpg vs. 9.2 mpg for the conventional group on those routes a year earlier. The hybrid group's fuel economy on the original hybrid route assignments was 9.4 mpg vs. 7.9 mpg for the conventional group on those routes a year later. There was no statistically significant difference in total maintenance cost per mile or for the vehicle total cost of operation per mile. Propulsion-related maintenance cost per mile was 77% higher for the hybrids, but only 52% more on a cost-per-delivery-day basis. Laboratory dynamometer testing demonstrated 13%-36% hybrid fuel economy improvement, depending on duty cycle, and up to a 45% improvement in ton-mi/gal. NOx emissions increased 21%-49% for the hybrids in laboratory testing.

  8. Preparation of a Magnetically Switchable Bioelectrocatalytic System Employing Cross-Linked Enzyme Aggregates in Magnetic Mesocellular Carbon Foam

    SciTech Connect (OSTI)

    Lee, Jinwoo; Lee, Dohun; Oh, Eunkeu; Kim, Jaeyun; Kim, Young-Pil; Jin, Sunmi; Kim, Hak Sung; Hwang, Yosun; Kwak, Ja Hun; Park, Je-Geun; Shin, Chae-Ho; Kim, Jungbae; Hyeon, Taeghwan

    2005-11-18

    Nanostructured magnetic materials (NMMs)[1] have attracted much attention recently because of their broad biotechnological applications including support matrices for enzyme immobilization,[2] immunoassays,[3] drug delivery,[4] and biosensors.[ 5] Specifically, the easy separation and controlled placement of NMMs by means of an external magnetic field enables their application in the development of immobilized enzyme processes[2] and the construction of magnetically controllable bio-electrocatalytic systems.[5, 6] Herein, we demonstrate the use of immobilized enzymes in NMMs for magnetically switchable bio-electrocatalysis.

  9. Commissioning a passive-scattering proton therapy nozzle for accurate SOBP delivery

    SciTech Connect (OSTI)

    Engelsman, M.; Lu, H.-M.; Herrup, D.; Bussiere, M.; Kooy, H. M.

    2009-06-15

    Proton radiotherapy centers that currently use passively scattered proton beams do field specific calibrations for a non-negligible fraction of treatment fields, which is time and resource consuming. Our improved understanding of the passive scattering mode of the IBA universal nozzle, especially of the current modulation function, allowed us to re-commission our treatment control system for accurate delivery of SOBPs of any range and modulation, and to predict the output for each of these fields. We moved away from individual field calibrations to a state where continued quality assurance of SOBP field delivery is ensured by limited system-wide measurements that only require one hour per week. This manuscript reports on a protocol for generation of desired SOBPs and prediction of dose output.

  10. Synthesis and characterization of pharmaceutical surfactant templated mesoporous silica: Its application to controlled delivery of duloxetine

    SciTech Connect (OSTI)

    Mani, Ganesh; Pushparaj, Hemalatha; Peng, Mei Mei; Muthiahpillai, Palanichamy; Udhumansha, Ubaidulla; Jang, Hyun Tae

    2014-03-01

    Graphical abstract: - Highlights: Usefulness of dual pharmaceutical surfactants in silica synthesis was evaluated. Effects of concentration of secondary template (Tween-40) were studied. Effects of fixed solvothermal condition on mesostructure formation were studied. Duloxetine drug loading capability was studied. Sustained release of duloxetine was evaluated. - Abstract: A new group of mesoporous silica nanoparticles (MSNs) were synthesized using combination pharmaceutical surfactants, Triton X-100 and Tween-40 as template and loaded with duloxetine hydrochloride (DX), for improving the sustained release of DX and patterns with high drug loading. Agglomerated spherical silica MSNs were synthesized by solgel and solvothermal methods. The calcined and drug loaded MSNs were characterized using X-ray diffraction (XRD), BraunnerEmmettTeller (BET), thermogravimetric analysis (TGA), Fourier-transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), differential scanning calorimetry (DSC), diffuse reflectance ultravioletvisible (DRS-UVvis) spectroscopy. MSNs with high surface area and pore volume were selected and studied for their DX loading and release. The selected MSNs can accommodate a maximum of 34% DX within it. About 90% was released at 200 h and hence, the synthesized MSNs were capable of engulfing DX and sustain its release. Further form the Ritger and Peppas, Higuchi model for mechanism drug release from all the MSN matrices follows anomalous transport or Non-Fickian diffusion with the r and n value 0.9 and 0.45 < n < 1, respectively. So, from this study it could be concluded that the MSNs synthesized using pharmaceutical templates were better choice of reservoir for the controlled delivery of drug which requires sustained release.

  11. MEMORANDUM TO: Honorable Patricia Hoffman, Assistant Secretary for Electricity Delivery

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    MEMORANDUM TO: Honorable Patricia Hoffman, Assistant Secretary for Electricity Delivery and Energy Reliability, U.S. Department of Energy FROM: Electricity Advisory Committee (EAC) Richard Cowart, Chair DATE: September 24, 2014 RE: Status and Recommendations for Electricity Delivery Workforce _________________________________________________________________________ Introduction In October, 2012 the EAC submitted a paper to the Secretary of the U.S. Department of Energy recommending actions that

  12. Electric Power Delivery Testing Feasibility Study Task 6 Final Report

    SciTech Connect (OSTI)

    Thomas Tobin

    2009-07-01

    This Final Report is covers the completion of the Electric Power Delivery Testing Feasibility Study. The objective of this project was to research, engineer, and demonstrate high-power laboratory testing protocols to accurately reproduce the conditions on the electric power grid representing both normal load switching and abnormalities such as short-circuit fault protection. Test circuits, equipment, and techniques were developed and proven at reduced power levels to determine the feasibility of building a large-scale high-power testing laboratory capable of testing equipment and systems at simulated high-power conditions of the U.S. power grid at distribution levels up through 38 kiloVolts (kV) and transmission levels up through 230 kV. The project delivered demonstrated testing techniques, high-voltage test equipment for load testing and synthetic short-circuit testing, and recommended designs for future implementation of a high-power testing laboratory to test equipment and systems, enabling increased reliability of the electric transmission and distribution grid.

  13. Drug Testing for DOE Positions | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Drug Testing for DOE Positions Drug Testing for DOE Positions Drug Testing for DOE Positions Drug Testing Matrix Secretary Bodman's Memorandum Regarding Drug Testing at DOE Fact ...

  14. H2A Delivery Components Model and Analysis | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Delivery Components Model and Analysis H2A Delivery Components Model and Analysis Presentation on H2A Delivery Components Model and Analysis for the DOE Hydrogen Delivery High-Pressure Tanks and Analysis Project Review Meeting held February 8-9, 2005 at Argonne National Laboratory 05_ringer_h2a.pdf (788.97 KB) More Documents & Publications H2A Delivery Models and Results Hydrogen Delivery Analysis Plus Meeting: DTT, STT, HPTT, Other Analysts, Invited Guests

  15. U.S. Department of Energy Office of Electricity Delivery & Energy...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Office of Electricity Delivery & Energy Reliability: Transmission Reliability Program U.S. Department of Energy Office of Electricity Delivery & Energy ...

  16. DOE Fuel Cell Technologies Office Record 13013: H2 Delivery Cost...

    Energy Savers

    3013: H2 Delivery Cost Projections - 2013 DOE Fuel Cell Technologies Office Record 13013: H2 Delivery ... past, current, and projected costs for delivering and dispensing hydrogen. ...

  17. FY 2012 Budget Control Table for the Office of Electricity Delivery...

    Energy Savers

    FY 2012 Budget Control Table for the Office of Electricity Delivery and Energy Reliability FY 2012 Budget Control Table for the Office of Electricity Delivery and Energy...

  18. IDC System Specification Document.

    SciTech Connect (OSTI)

    Clifford, David J.

    2014-12-01

    This document contains the system specifications derived to satisfy the system requirements found in the IDC System Requirements Document for the IDC Reengineering Phase 2 project. Revisions Version Date Author/Team Revision Description Authorized by V1.0 12/2014 IDC Reengineering Project Team Initial delivery M. Harris

  19. Dynamic Line Rating Oncor Electric Delivery Smart Grid Program

    SciTech Connect (OSTI)

    Johnson, Justin; Smith, Cale; Young, Mike; Donohoo, Ken; Owen, Ross; Clark, Eddit; Espejo, Raul; Aivaliotis, Sandy; Stelmak, Ron; Mohr, Ron; Barba, Cristian; Gonzalez, Guillermo; Malkin, Stuart; Dimitrova, Vessela; Ragsdale, Gary; Mitchem, Sean; Jeirath, Nakul; Loomis, Joe; Trevino, Gerardo; Syracuse, Steve; Hurst, Neil; Mereness, Matt; Johnson, Chad; Bivens, Carrie

    2013-05-04

    Electric transmission lines are the lifeline of the electric utility industry, delivering its product from source to consumer. This critical infrastructure is often constrained such that there is inadequate capacity on existing transmission lines to efficiently deliver the power to meet demand in certain areas or to transport energy from high-generation areas to high-consumption regions. When this happens, the cost of the energy rises; more costly sources of power are used to meet the demand or the system operates less reliably. These economic impacts are known as congestion, and they can amount to substantial dollars for any time frame of reference: hour, day or year. There are several solutions to the transmission constraint problem, including: construction of new generation, construction of new transmission facilities, rebuilding and reconductoring of existing transmission assets, and Dynamic Line Rating (DLR). All of these options except DLR are capital intensive, have long lead times and often experience strong public and regulatory opposition. The Smart Grid Demonstration Program (SGDP) project co-funded by the Department of Energy (DOE) and Oncor Electric Delivery Company developed and deployed the most extensive and advanced DLR installation to demonstrate that DLR technology is capable of resolving many transmission capacity constraint problems with a system that is reliable, safe and very cost competitive. The SGDP DLR deployment is the first application of DLR technology to feed transmission line real-time dynamic ratings directly into the system operation’s State Estimator and load dispatch program, which optimizes the matching of generation with load demand on a security, reliability and economic basis. The integrated Dynamic Line Rating (iDLR)1 collects transmission line parameters at remote locations on the lines, calculates the real-time line rating based on the equivalent conductor temperature, ambient temperature and influence of wind and solar

  20. Improvements to Hydrogen Delivery Scenario Analysis Model (HDSAM) and Results

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Improvements to Hydrogen Delivery Scenario Analysis Model (HDSAM) and Results May 8, 2007 Amgad Elgowainy Argonne National Laboratory Comparison of Delivery Pathways- V1.0 vs. V2.0 2 1 3 i delivery by a Loading, the plant Version 1.0 character zed components for 3 pathways with single mode. conditioning and storage are at or adjacent to Liquid Hydrogen (LH) Truck H2 Production 100 or 1500 kg/d Compressed H2 (CH) Truck H2 Production 3 or 7 kpsi 100 or 1500 kg/d H2 Production Gaseous H2 Pipeline

  1. PECO energy adopts reliability centered maintenance to improve preventive maintanance of power delivery equipment

    SciTech Connect (OSTI)

    Maurer, R.; Linn, P.; Termine, G.; Schwan, C.

    1996-08-01

    One of the biggest challenges facing PECO Energy, in the area of power delivery, is holding the line on maintenance costs while preserving high levels of worker safety, enhancing equipment reliability, and improving customer satisfaction. PECO has taken an early lead in tackling this apparent industry-wide problem by adopting a proven preventive maintenance (PM) optimization method known as Reliability Centered Maintenance (RCM). The purpose of this paper is to explain: (1) how RCM was successfully introduced at PECO using data, lessons learned and consulting support associated with EPRI`s RCM for Substations research project; (2) how the RCM methodology will be implemented over the long term for the Power Delivery System; and (3) how the RCM activities will help lead to the development of a living PM program that will foster a continuous improvement in equipment reliability through cost-effective preventive maintenance.

  2. Target isolation system, high power laser and laser peening method and system using same

    DOE Patents [OSTI]

    Dane, C. Brent; Hackel, Lloyd A.; Harris, Fritz

    2007-11-06

    A system for applying a laser beam to work pieces, includes a laser system producing a high power output beam. Target delivery optics are arranged to deliver the output beam to a target work piece. A relay telescope having a telescope focal point is placed in the beam path between the laser system and the target delivery optics. The relay telescope relays an image between an image location near the output of the laser system and an image location near the target delivery optics. A baffle is placed at the telescope focal point between the target delivery optics and the laser system to block reflections from the target in the target delivery optics from returning to the laser system and causing damage.

  3. Evaluating Feed Delivery Performance in Scaled Double-Shell Tanks

    SciTech Connect (OSTI)

    Lee, Kearn P.; Thien, Michael G.

    2013-11-07

    The Hanford Tank Operations Contractor (TOC) and the Hanford Waste Treatment and Immobilization Plant (WTP) contractor are both engaged in demonstrating mixing, sampling, and transfer system capability using simulated Hanford High-Level Waste (HLW) formulations. This work represents one of the remaining technical issues with the high-level waste treatment mission at Hanford. The TOCs' ability to adequately mix and sample high-level waste feed to meet the WTP WAC Data Quality Objectives must be demonstrated. The tank mixing and feed delivery must support both TOC and WTP operations. The tank mixing method must be able to remove settled solids from the tank and provide consistent feed to the WTP to facilitate waste treatment operations. Two geometrically scaled tanks were used with a broad spectrum of tank waste simulants to demonstrate that mixing using two rotating mixer jet pumps yields consistent slurry compositions as the tank is emptied in a series of sequential batch transfers. Testing showed that the concentration of slow settling solids in each transfer batch was consistent over a wide range of tank operating conditions. Although testing demonstrated that the concentration of fast settling solids decreased by up to 25% as the tank was emptied, batch-to-batch consistency improved as mixer jet nozzle velocity in the scaled tanks increased.

  4. A Case Study in Proton Pencil-Beam Scanning Delivery

    SciTech Connect (OSTI)

    Kooy, Hanne M.; Clasie, Benjamin M.; Lu, H.-M.; Madden, Thomas M.; Bentefour, Hassan; Depauw, Nicolas M.S.; Adams, Judy A.; Trofimov, Alexei V.; Demaret, Denis; Delaney, Thomas F.; Flanz, Jacob B.

    2010-02-01

    Purpose: We completed an implementation of pencil-beam scanning (PBS), a technology whereby a focused beam of protons, of variable intensity and energy, is scanned over a plane perpendicular to the beam axis and in depth. The aim of radiotherapy is to improve the target to healthy tissue dose differential. We illustrate how PBS achieves this aim in a patient with a bulky tumor. Methods and Materials: Our first deployment of PBS uses 'broad' pencil-beams ranging from 20 to 35 mm (full-width-half-maximum) over the range interval from 32 to 7 g/cm{sup 2}. Such beam-brushes offer a unique opportunity for treating bulky tumors. We present a case study of a large (4,295 cc clinical target volume) retroperitoneal sarcoma treated to 50.4 Gy relative biological effectiveness (RBE) (presurgery) using a course of photons and protons to the clinical target volume and a course of protons to the gross target volume. Results: We describe our system and present the dosimetry for all courses and provide an interdosimetric comparison. Discussion: The use of PBS for bulky targets reduces the complexity of treatment planning and delivery compared with collimated proton fields. In addition, PBS obviates, especially for cases as presented here, the significant cost incurred in the construction of field-specific hardware. PBS offers improved dose distributions, reduced treatment time, and reduced cost of treatment.

  5. Joint Meeting on Hydrogen Delivery Modeling and Analysis Meeting...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Bruce Kelly 9:30 Miscellaneous Costs - Indirect Capital, O&M Factors, Labor and Labor Scaling, Losses: Matt Ringer 9:45 Break 10:00 H2A Delivery Model: New Results and Discussion: ...

  6. Percent of Commercial Natural Gas Deliveries in California Represented...

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    California Represented by the Price (Percent) Percent of Commercial Natural Gas Deliveries in California Represented by the Price (Percent) Year Jan Feb Mar Apr May Jun Jul Aug Sep ...

  7. Inexpensive Delivery of Compressed Hydrogen with Advanced Vessel...

    Energy.gov (indexed) [DOE]

    (367.52 KB) More Documents & Publications President's Hydrogen Fuel Initiative Overview of FreedomCAR & Fuels PartnershipDOE Delivery Program High-Pressure Tube Trailers and Tanks

  8. Vacancy Announcements Posted for Hydrogen Production and Delivery Program

    Energy.gov [DOE]

    The Fuel Cell Technologies Office has posted two vacancy announcements for a position to serve as Program Manager for the Hydrogen Production and Delivery Program in the DOE EERE Fuel Cell Technologies Office. The closing date is October 28, 2014.

  9. Percent of Industrial Natural Gas Deliveries in New Mexico Represented...

    U.S. Energy Information Administration (EIA) (indexed site)

    Mexico Represented by the Price (Percent) Percent of Industrial Natural Gas Deliveries in New Mexico Represented by the Price (Percent) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct ...

  10. Natural Gas Deliveries to Commercial Consumers (Including Vehicle...

    U.S. Energy Information Administration (EIA) (indexed site)

    Mexico (Million Cubic Feet) Natural Gas Deliveries to Commercial Consumers (Including Vehicle Fuel through 1996) in New Mexico (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul ...

  11. Ms. Julie Smith Office of Electricity Delivery and Energy Reliability

    Energy.gov (indexed) [DOE]

    Julie Smith Office of Electricity Delivery and Energy Reliability Mail Code OE-20 U.S. Department of Energy 1000 Independence Avenue Washington, D.C. 20585 Juliea.smith@hq.doe.gov; ...

  12. Lighting and Electrical Team Leadership and Project Delivery - 2014 BTO

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Peer Review | Department of Energy and Electrical Team Leadership and Project Delivery - 2014 BTO Peer Review Lighting and Electrical Team Leadership and Project Delivery - 2014 BTO Peer Review Project Objective The partners involved in the Lighting Energy Efficiency in Parking (LEEP) campaign, along with private and public entities, advocate for and install energy-efficient lighting in public parking lots to foster significant reductions in participants' energy consumption. The project's

  13. OFFICE OF ELECTRICITY DELIVERY AND ENERGY RELIABILITY WEEKLY REPORT

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ELECTRICITY DELIVERY AND ENERGY RELIABILITY WEEKLY REPORT April 17, 2009 Schedule Patricia A. Hoffman, Acting Assistant Secretary, does not have any travel or leave plans for the week beginning April 20, 2009. Key Departmental News OE Staff Participate in TSA/DOT Pipeline Security and Incident Recovery Planning Meeting. On April 1-2, Office of Electricity Delivery and Energy Reliability (OE) staff participated in a Transportation Security Administration (TSA) and Department of Transportation

  14. Examination of Terminal Land Requirements for Hydrogen Delivery

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    May 8, 2007 Jerry Gillette Examination of Terminal Land Requirements for Hydrogen Hydrogen Delivery Analysis Meeting Argonne National Laboratory A Variety of Terminal Configurations May Exist for Various Hydrogen Delivery Pathways „ Gaseous Tube Trailer Pathway - Receive hydrogen from production plant - Store low volumes of gaseous hydrogen for operational stability - Compress hydrogen for storage and/or charging tube trailers - Charge tube trailers in loading bays - Options for production

  15. Renewable Electricity Generation and Delivery at the Sacramento Municipal

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Utility District | Department of Energy Electricity Generation and Delivery at the Sacramento Municipal Utility District Renewable Electricity Generation and Delivery at the Sacramento Municipal Utility District Dairy digester and engine genset at New Hope dairy farm. | <em>Photo courtesy of Sacramento Municipal Utility District</em> Dairy digester and engine genset at New Hope dairy farm. | Photo courtesy of Sacramento Municipal Utility District The Sacramento Municipal Utility

  16. Office of Electricity Delivery and Energy Reliability Recovery Program Plan

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    | Department of Energy Electricity Delivery and Energy Reliability Recovery Program Plan Office of Electricity Delivery and Energy Reliability Recovery Program Plan Microsoft Word - OE PSRP June 5 2009 _OE_ Final.doc (105.88 KB) More Documents & Publications Microsoft Word - PSRP Updates 6-25-10_v2 Update to the 2008 EAC Report: "Smart Grid: Enabler of the New Energy Economy Report Recommendations" EAC Presentation: How DOE is Organized to Provide Leadership on Electricity

  17. California Save Energy Now: State, Regional, and Local Delivery |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Technical Assistance » State and Utility Engagement Activities » California Save Energy Now: State, Regional, and Local Delivery California Save Energy Now: State, Regional, and Local Delivery Map highlighting California The industrial sector in California accounts for approximately one-third of the state's natural gas consumption and one-sixth of its electricity consumption. With approximately 50,000 industrial plants in the state, California manufacturers account for

  18. NREL: Hydrogen and Fuel Cells Research - Hydrogen Production and Delivery

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Hydrogen Production and Delivery Learn how NREL is developing and advancing a number of pathways to renewable hydrogen production. Text Version Most of the hydrogen in the United States is produced by steam reforming of natural gas. For the near term, this production method will continue to dominate. Researchers at NREL are developing advanced processes to produce hydrogen economically from sustainable resources. NREL's hydrogen production and delivery R&D efforts, which are led by Huyen

  19. Statement Of Patricia Hoffman, Assistant Secretary For Electricity Delivery

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    and Energy Reliability, Before The United States House of Representatives Appropriations Subcommittee on Energy and Water Development, March 17, 2015 | Department of Energy Of Patricia Hoffman, Assistant Secretary For Electricity Delivery and Energy Reliability, Before The United States House of Representatives Appropriations Subcommittee on Energy and Water Development, March 17, 2015 Statement Of Patricia Hoffman, Assistant Secretary For Electricity Delivery and Energy Reliability, Before

  20. Statement Of Patricia Hoffman, Assistant Secretary For Electricity Delivery

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    and Energy Reliability, Before The United States House of Representatives Appropriations Subcommittee on Energy and Water Development, March 25, 2014 | Department of Energy Of Patricia Hoffman, Assistant Secretary For Electricity Delivery and Energy Reliability, Before The United States House of Representatives Appropriations Subcommittee on Energy and Water Development, March 25, 2014 Statement Of Patricia Hoffman, Assistant Secretary For Electricity Delivery and Energy Reliability, Before

  1. Statement of Patricia Hoffman, Assistant Secretary for Electricity Delivery

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    and Energy Reliability, before the House Appropriations Subcommittee on Energy and Water Development, March 30, 2011 | Department of Energy House Appropriations Subcommittee on Energy and Water Development, March 30, 2011 Statement of Patricia Hoffman, Assistant Secretary for Electricity Delivery and Energy Reliability, before the House Appropriations Subcommittee on Energy and Water Development, March 30, 2011 Statement of Patricia Hoffman, Assistant Secretary for Electricity Delivery and

  2. Status and EAC Recommendations for Electricity Delivery Workforce

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    (September 2014) | Department of Energy Status and EAC Recommendations for Electricity Delivery Workforce (September 2014) Status and EAC Recommendations for Electricity Delivery Workforce (September 2014) This memo, approved at the September 2014 EAC meeting and delivered to the Department of Energy, reports on the activities since September 2013 of the Workforce Work Group and makes recommendations to the DOE. The recommendations include the development of a DOE response to an October 2012

  3. Testimony Of Patricia Hoffman, Assistant Secretary For Electricity Delivery

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    and Energy Reliability, U.S. Department of Energy before the House Committee on Transportation and Infrastructure April 14, 2016 | Department of Energy Of Patricia Hoffman, Assistant Secretary For Electricity Delivery and Energy Reliability, U.S. Department of Energy before the House Committee on Transportation and Infrastructure April 14, 2016 Testimony Of Patricia Hoffman, Assistant Secretary For Electricity Delivery and Energy Reliability, U.S. Department of Energy before the House

  4. Vehicle Technologies Office - AVTA: All Electric Delivery Trucks |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Delivery Trucks Vehicle Technologies Office - AVTA: All Electric Delivery Trucks The Vehicle Technologies Office's Advanced Vehicle Testing Activity carries out testing on a wide range of advanced vehicles and technologies on dynamometers, closed test tracks, and on-the-road. These results provide benchmark data that researchers can use to develop technology models and guide future research and development. The following set of reports (part of the medium and heavy-duty

  5. Vehicle Technologies Office - AVTA: Hybrid-Electric Delivery Vehicles |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Delivery Vehicles Vehicle Technologies Office - AVTA: Hybrid-Electric Delivery Vehicles The Vehicle Technologies Office's Advanced Vehicle Testing Activity carries out testing on a wide range of advanced vehicles and technologies on dynamometers, closed test tracks, and on-the-road. These results provide benchmark data that researchers can use to develop technology models and guide future research and development. The following set of reports (part of the medium and

  6. Record of Categorical Exclusion (CX) Office of Electricity Delivery and

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energy Reliability (OE): EA-405 Del Norte Energy LLC | Department of Energy Office of Electricity Delivery and Energy Reliability (OE): EA-405 Del Norte Energy LLC Record of Categorical Exclusion (CX) Office of Electricity Delivery and Energy Reliability (OE): EA-405 Del Norte Energy LLC Application from Del Norte to export electric energy to Mexico. Record of Categorical Exclusion (CX) Determination. EA-405 Del Norte Energy.pdf (77.47 KB) More Documents & Publications Record of

  7. Competition Advocates and Task-Order and Delivery Order Ombudsman |

    National Nuclear Security Administration (NNSA)

    National Nuclear Security Administration | (NNSA) Acquisition Management Competition Advocates and Task-Order and Delivery Order Ombudsman There are two senior agency positions dedicated to ensuring full and open competition as a part of the federal contracting process: Competition Advocates and Task-Order and Delivery Order Ombudsman. Competition Advocates are responsible for: Promoting full and open competition; Promoting the acquisition of commercial items; Removing barriers to full and

  8. Two-dimensional inverse planning and delivery with a preclinical image guided microirradiator

    SciTech Connect (OSTI)

    Stewart, James M. P.; Lindsay, Patricia E.; Jaffray, David A.; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9; Department of Radiation Oncology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 3E2; Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9; The Techna Institute for the Advancement of Technology for Health, Toronto, Ontario M5G 1P5

    2013-10-15

    Purpose: Recent advances in preclinical radiotherapy systems have provided the foundation for scaling many of the elements of clinical radiation therapy practice to the dimensions and energy demanded in small animal studies. Such systems support the technical capabilities to accurately deliver highly complex dose distributions, but methods to optimize and deliver such distributions remain in their infancy. This study developed an optimization method based on empirically measured two-dimensional dose kernel measurements to deliver arbitrary planar dose distributions on a recently developed small animal radiotherapy platform.Methods: A two-dimensional dose kernel was measured with repeated radiochromic film measurements for the circular 1 mm diameter fixed collimator of the small animal radiotherapy system at 1 cm depth in a solid water phantom. This kernel was utilized in a sequential quadratic programming optimization framework to determine optimal beam positions and weights to deliver an arbitrary desired dose distribution. The positions and weights were then translated to a set of stage motions to automatically deliver the optimized dose distribution. End-to-end efficacy of the framework was quantified through five repeated deliveries of two dosimetric challenges: (1) a 5 mm radius bullseye distribution, and (2) a sock distribution contained within a 9 13 mm bounding box incorporating rectangular, semicircular, and exponentially decaying geometric constructs and a rectangular linear dose gradient region. These two challenges were designed to gauge targeting, geometric, and dosimetric fidelity.Results: Optimization of the bullseye and sock distributions required 2.1 and 5.9 min and utilized 50 and 77 individual beams for delivery, respectively. Automated delivery of the resulting optimized distributions, validated using radiochromic film measurements, revealed an average targeting accuracy of 0.32 mm, and a dosimetric delivery error along four line profiles

  9. AutoDrug: fully automated macromolecular crystallography workflows for fragment-based drug discovery

    SciTech Connect (OSTI)

    Tsai, Yingssu; McPhillips, Scott E.; Gonzlez, Ana; McPhillips, Timothy M.; Zinn, Daniel; Cohen, Aina E.; Feese, Michael D.; Bushnell, David; Tiefenbrunn, Theresa; Stout, C. David; Ludaescher, Bertram; Hedman, Britt; Hodgson, Keith O.; Soltis, S. Michael

    2013-05-01

    New software has been developed for automating the experimental and data-processing stages of fragment-based drug discovery at a macromolecular crystallography beamline. A new workflow-automation framework orchestrates beamline-control and data-analysis software while organizing results from multiple samples. AutoDrug is software based upon the scientific workflow paradigm that integrates the Stanford Synchrotron Radiation Lightsource macromolecular crystallography beamlines and third-party processing software to automate the crystallography steps of the fragment-based drug-discovery process. AutoDrug screens a cassette of fragment-soaked crystals, selects crystals for data collection based on screening results and user-specified criteria and determines optimal data-collection strategies. It then collects and processes diffraction data, performs molecular replacement using provided models and detects electron density that is likely to arise from bound fragments. All processes are fully automated, i.e. are performed without user interaction or supervision. Samples can be screened in groups corresponding to particular proteins, crystal forms and/or soaking conditions. A single AutoDrug run is only limited by the capacity of the sample-storage dewar at the beamline: currently 288 samples. AutoDrug was developed in conjunction with RestFlow, a new scientific workflow-automation framework. RestFlow simplifies the design of AutoDrug by managing the flow of data and the organization of results and by orchestrating the execution of computational pipeline steps. It also simplifies the execution and interaction of third-party programs and the beamline-control system. Modeling AutoDrug as a scientific workflow enables multiple variants that meet the requirements of different user groups to be developed and supported. A workflow tailored to mimic the crystallography stages comprising the drug-discovery pipeline of CoCrystal Discovery Inc. has been deployed and successfully

  10. Engineering Basis Document Review for Waste Feed Delivery from Single Shell Tanks (SST)

    SciTech Connect (OSTI)

    SMITH, D.F.

    1999-10-07

    This report provides the results of a review conducted on existing operating specifications and safety requirements and provides a summary of applicable design constraints on the Single-Shell Tank (SST) System. The SST System is required to transition from the current waste storage mission to support the Tank Waste Remediation System (TWRS) waste retrieval mission described in the Tank Waste Remediation System Mission Analysis Report (Acree 1998). The SST System is also required to support the Project Hanford Management Contract (PHMC) portions of the Waste Feed Delivery (WFD) mission. In Phase 1 the SST System will be required to retrieve waste from selected SSTs (tanks 241-C-102 and 241-C-104) for transfer to the Double-Shell Tank (DST) System (tanks 241-AZ-101,241-AY-102). The SST System will include all the systems, structures and components required to safely store, retrieve, and transfer waste in support of the TWRS mission. Operational Specification Documents (OSDs) govern operation of the existing SST System components. However, the system will be highly modified to support the TWRS mission. Therefore OSD requirements may not apply to the new system's design. This document describes the review of existing SST OSDs and provides the rationale for selecting or rejecting requirements as constraints on the SST System design. The selected requirements (or design constraints) will be included in System Specification for the Single-Shell Tank System, HNF-3912(Conrads 1999).

  11. Technoeconomic Analysis of Biomethane Production from Biogas and Pipeline Delivery (Presentation)

    SciTech Connect (OSTI)

    Jalalzadeh-Azar, A.

    2010-10-18

    This presentation summarizes "A Technoeconomic Analysis of Biomethane Production from Biogas and Pipeline Delivery".

  12. R&D program benefits estimation: DOE Office of Electricity Delivery and Energy Reliability

    SciTech Connect (OSTI)

    None, None

    2006-12-04

    The overall mission of the U.S. Department of Energy’s Office of Electricity Delivery and Energy Reliability (OE) is to lead national efforts to modernize the electric grid, enhance the security and reliability of the energy infrastructure, and facilitate recovery from disruptions to the energy supply. In support of this mission, OE conducts a portfolio of research and development (R&D) activities to advance technologies to enhance electric power delivery. Multiple benefits are anticipated to result from the deployment of these technologies, including higher quality and more reliable power, energy savings, and lower cost electricity. In addition, OE engages State and local government decision-makers and the private sector to address issues related to the reliability and security of the grid, including responding to national emergencies that affect energy delivery. The OE R&D activities are comprised of four R&D lines: High Temperature Superconductivity (HTS), Visualization and Controls (V&C), Energy Storage and Power Electronics (ES&PE), and Distributed Systems Integration (DSI).

  13. Smarter Drugs: How Protein Crystallography Revolutionizes Drug Design

    SciTech Connect (OSTI)

    Smith, Clyde

    2005-04-26

    According to Smith, protein crystallography allows scientists to design drugs in a much more efficient way than the standard methods traditionally used by large drug companies, which can cost close to a billion dollars and take 10 to 15 years. 'A lot of the work can be compressed down,' Smith said. Protein crystallography enables researchers to learn the structure of molecules involved in disease and health. Seeing the loops, folds and placement of atoms in anything from a virus to a healthy cell membrane gives important information about how these things work - and how to encourage, sidestep or stop their functions. Drug design can be much faster when the relationship between structure and function tells you what area of a molecule to target. Smith will use a timeline to illustrate the traditional methods of drug development and the new ways it can be done now. 'It is very exciting work. There have been some failures, but many successes too.' A new drug to combat the flu was developed in a year or so. Smith will tell us how. He will also highlight drugs developed to combat HIV, Tuberculosis, hypertension and Anthrax.

  14. State Geothermal Data data delivery tools

    Energy Science and Technology Software Center (OSTI)

    2009-08-01

    This web site provides a single online system for AASG State Geothermal Data participants to integrate their data into the NGDS, discovering how to digitize at-risk, legacy, geothermal-relevant data and combine it with existing digital data to create a publicly accessible system.

  15. Separate lubricating system for marine propulsion device

    SciTech Connect (OSTI)

    Matsumoto, K.

    1986-02-25

    This patent describes a lubricating system for a two-cycle internal combustion engine. This system consists of a relatively large remotely positioned lubricant storage tank a relatively small lubricant delivery tank positioned in proximity to the engine for delivering lubricant to its lubricating system and means responsive to the level of lubricant in the delivery tank for transferring lubricant to maintain a predetermined level of lubricant in the delivery tank. The improvement consists of means for providing a warning signal when the level of lubricant in the storage tank falls below a predetermined amount. The means for providing the warning signal operate further to discontinue the transfer of lubricant from the storage tank to the delivery tank. There also is a manual override for operating the means for transferring lubricant from the storage tank to the delivery tank under operator control even when the warning signal has been activated.

  16. H2A Delivery: Miscellaneous Cost and H2 Losses | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Miscellaneous Cost and H2 Losses H2A Delivery: Miscellaneous Cost and H2 Losses Presentation by Matt Ringer of the National Renewable Energy Laboratory at the Joint Meeting on Hydrogen Delivery Modeling and Analysis, May 8-9, 2007 deliv_analysis_ringer.pdf (327.03 KB) More Documents & Publications H2A Delivery Models and Results Hydrogen Delivery Analysis Models H2A Delivery Components Model and Analysis

  17. Random Selection for Drug Screening (Technical Report) | SciTech...

    Office of Scientific and Technical Information (OSTI)

    Subject: 99 GENERAL AND MISCELLANEOUSMATHEMATICS, COMPUTING, AND INFORMATION SCIENCE; PROBABILITY; SAMPLING; DRUG ABUSE; DRUGS; CRIME DETECTION drug screenings, random selection ...

  18. Drug Testing - Memo from Glenn S. Podonsky

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Additionally, the Secretary has determined individuals who have used illegal drugs within ... such time as they can demonstrate non-use of illegal drugs for 12 consecutive months. ...

  19. Tank Farms and Waste Feed Delivery - 12507

    SciTech Connect (OSTI)

    Fletcher, Thomas; Charboneau, Stacy; Olds, Erik

    2012-07-01

    The mission of the Department of Energy's Office of River Protection (ORP) is to safely retrieve and treat the 56 million gallons of Hanford's tank waste and close the Tank Farms to protect the Columbia River. Our discussion of the Tank Farms and Waste Feed Delivery will cover progress made to date with Base and Recovery Act funding in reducing the risk posed by tank waste and in preparing for the initiation of waste treatment at Hanford. The millions of gallons of waste are a by-product of decades of plutonium production. After irradiated fuel rods were taken from the nuclear reactors to the processing facilities at Hanford they were exposed to a series of chemicals designed to dissolve away the rod, which enabled workers to retrieve the plutonium. Once those chemicals were exposed to the fuel rods they became radioactive and extremely hot. They also couldn't be used in this process more than once. Because the chemicals are caustic and extremely hazardous to humans and the environment, underground storage tanks were built to hold these chemicals until a more permanent solution could be found. The underground storage tanks range in capacity from 55,000 gallons to more than 1 million gallons. The tanks were constructed with carbon steel and reinforced concrete. There are eighteen groups of tanks, called 'tank farms', some having as few as two tanks and others up to sixteen tanks. Between 1943 and 1964, 149 single-shell tanks were built at Hanford in the 200 West and East Areas. Heat generated by the waste and the composition of the waste caused an estimated 67 of these single-shell tanks to leak into the ground. Washington River Protection Solutions is the prime contractor responsible for the safe management of this waste. WRPS' mission is to reduce the risk to the environment that is posed by the waste. All of the pumpable liquids have been removed from the single-shell tanks and transferred to the double-shell tanks. What remains in the single-shell tanks are

  20. Test report light duty utility arm power distribution system (PDS)

    SciTech Connect (OSTI)

    Clark, D.A.

    1996-03-04

    The Light Duty Utility Arm (LDUA) Power Distribution System has completed vendor and post-delivery acceptance testing. The Power Distribution System has been found to be acceptable and is now ready for integration with the overall LDUA system.

  1. SAXS Workshop

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    within elastomeric polypropylene; materials synthesis: where living polymerization techniques permit construction of dendrimer structures for drug delivery systems;...

  2. SU-E-T-213: Initial Experience with VMAT Plan and Delivery Verification Using a DICOM-RT Framework and Linac Delivery Log Files

    SciTech Connect (OSTI)

    Reynolds, R; Pompos, A; Gu, X; Jiang, S; Stojadinovic, S

    2014-06-01

    Purpose: Mobius3D/MobiusFX (M3D/MFX), a commercial DICOM-RT based plan and delivery verification system, was used to compare calculated and delivered volumetric modulated arc therapy (VMAT) dose distributions using TrueBeam delivery log files (TrajectoryLogs). Methods: M3D/MFX utilizes measured linac commissioning data to generate institution specific beam models for evaluating planned and delivered dose distributions. 30 RapidArc prostate plans and 30 head and neck SmartArc plans were used in this study. For every plan, CT images, contoured structure sets, RT-plan, and RT-dose files were exported to M3D, which recalculated the patients’ planning CT dose distributions using a collapsed-cone-convolutionsuperposition algorithm. MFX utilized the acquired TrajectoryLogs to compute patients’ delivered dose distributions based on actual treatment delivery parameters. The agreement between computed and delivered dose distributions was evaluated utilizing a (3%, 3mm) global 3D-gamma analysis and dose-volume histogram changes for targets and organs at risk. Results: Excellent 3D-gamma agreements were observed for all VMAT plans. On average, for computed and delivered RapidArc and SmartArc plans the gamma passing rates were (99.0%±1.4%) and (96.8%±1.8%), respectively. The average difference for primary target prescription dose percent-coverage between calculated and delivered plans was (− 0.09%±2.52%) for RapidArc and (−2.71%±4.62%) for SmartArc cases. Similarly, the planning target mean dose differences were (1.38%±0.96%) for RapidArc and (1.17%±0.72%) for SmartArc plans. For the prostate plans, the calculated and delivered variations of the maximum dose for a 2cc volume for bladder and rectum were (1.32%±1.26%) and (0.65%±1.44%), respectively. The spinal-cord 2cc maximum dose differences of (3.26%±1.68%) were observed for the SmartArc plans. Conclusions: Clinical quality assurance practice based on linac treatment log files for verification of delivered 3D

  3. Cell-penetrating DNA-binding protein as a safe and efficient naked DNA delivery carrier in vitro and in vivo

    SciTech Connect (OSTI)

    Kim, Eun-Sung; Yang, Seung-Woo; Hong, Dong-Ki; Kim, Woo-Taek; Kim, Ho-Guen; Lee, Sang-Kyou

    2010-01-29

    Non-viral gene delivery is a safe and suitable alternative to viral vector-mediated delivery to overcome the immunogenicity and tumorigenesis associated with viral vectors. Using the novel, human-origin Hph-1 protein transduction domain that can facilitate the transduction of protein into cells, we developed a new strategy to deliver naked DNA in vitro and in vivo. The new DNA delivery system contains Hph-1-GAL4 DNA-binding domain (DBD) fusion protein and enhanced green fluorescent protein (EGFP) reporter plasmid that includes the five repeats of GAL4 upstream activating sequence (UAS). Hph-1-GAL4-DBD protein formed complex with plasmid DNA through the specific interaction between GAL4-DBD and UAS, and delivered into the cells via the Hph-1-PTD. The pEGFP DNA was successfully delivered by the Hph-1-GAL4 system, and the EGFP was effectively expressed in mammalian cells such as HeLa and Jurkat, as well as in Bright Yellow-2 (BY-2) plant cells. When 10 {mu}g of pEGFP DNA was intranasally administered to mice using Hph-1-GAL4 protein, a high level of EGFP expression was detected throughout the lung tissue for 7 days. These results suggest that an Hph-1-PTD-mediated DNA delivery strategy may be an useful non-viral DNA delivery system for gene therapy and DNA vaccines.

  4. Laser peening with fiber optic delivery

    DOE Patents [OSTI]

    Friedman, Herbert W.; Ault, Earl R.; Scheibner, Karl F.

    2004-11-16

    A system for processing a workpiece using a laser. The laser produces at least one laser pulse. A laser processing unit is used to process the workpiece using the at least one laser pulse. A fiber optic cable is used for transmitting the at least one laser pulse from the laser to the laser processing unit.

  5. Solar Energy: Technologies and Project Delivery | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Solar Energy: Technologies and Project Delivery Solar Energy: Technologies and Project Delivery November 10, 2016 9:00AM to 12:00PM EST Solar energy-including on-site photovoltaics, solar water heating, and solar ventilation air preheating-can contribute to meeting the renewable energy requirements of the Energy Policy Act of 2005, the Energy Independence and Security Act of 2007, and Executive Order 13693, which require the use renewable energy sources at federal sites. This in-person workshop

  6. ,"Alabama Natural Gas Percentage Total Commercial Deliveries (%)"

    U.S. Energy Information Administration (EIA) (indexed site)

    Commercial Deliveries (%)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Alabama Natural Gas Percentage Total Commercial Deliveries (%)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  7. ,"Alabama Natural Gas Percentage Total Industrial Deliveries (%)"

    U.S. Energy Information Administration (EIA) (indexed site)

    Industrial Deliveries (%)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Alabama Natural Gas Percentage Total Industrial Deliveries (%)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  8. U.S. Natural Gas % of Total Residential Deliveries (Percent)

    U.S. Energy Information Administration (EIA) (indexed site)

    Deliveries (Percent) U.S. Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 100 100 100 100 100 100 100 2000's 100 100 100 100 100 100 100 100 100 100 2010's 100 100 100 100 100 100 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: Share of Total U.S. Natural Gas

  9. The development and verification of a highly accurate collision prediction model for automated noncoplanar plan delivery

    SciTech Connect (OSTI)

    Yu, Victoria Y.; Tran, Angelia; Nguyen, Dan; Cao, Minsong; Ruan, Dan; Low, Daniel A.; Sheng, Ke

    2015-11-15

    Purpose: Significant dosimetric benefits had been previously demonstrated in highly noncoplanar treatment plans. In this study, the authors developed and verified an individualized collision model for the purpose of delivering highly noncoplanar radiotherapy and tested the feasibility of total delivery automation with Varian TrueBeam developer mode. Methods: A hand-held 3D scanner was used to capture the surfaces of an anthropomorphic phantom and a human subject, which were positioned with a computer-aided design model of a TrueBeam machine to create a detailed virtual geometrical collision model. The collision model included gantry, collimator, and couch motion degrees of freedom. The accuracy of the 3D scanner was validated by scanning a rigid cubical phantom with known dimensions. The collision model was then validated by generating 300 linear accelerator orientations corresponding to 300 gantry-to-couch and gantry-to-phantom distances, and comparing the corresponding distance measurements to their corresponding models. The linear accelerator orientations reflected uniformly sampled noncoplanar beam angles to the head, lung, and prostate. The distance discrepancies between measurements on the physical and virtual systems were used to estimate treatment-site-specific safety buffer distances with 0.1%, 0.01%, and 0.001% probability of collision between the gantry and couch or phantom. Plans containing 20 noncoplanar beams to the brain, lung, and prostate optimized via an in-house noncoplanar radiotherapy platform were converted into XML script for automated delivery and the entire delivery was recorded and timed to demonstrate the feasibility of automated delivery. Results: The 3D scanner measured the dimension of the 14 cm cubic phantom within 0.5 mm. The maximal absolute discrepancy between machine and model measurements for gantry-to-couch and gantry-to-phantom was 0.95 and 2.97 cm, respectively. The reduced accuracy of gantry-to-phantom measurements was

  10. AFM fluid delivery/liquid extraction surface sampling/electrostatic spray cantilever probe

    SciTech Connect (OSTI)

    Van Berkel, Gary J.

    2015-06-23

    An electrospray system comprises a liquid extraction surface sampling probe. The probe comprises a probe body having a liquid inlet and a liquid outlet, and having a liquid extraction tip. A solvent delivery conduit is provided for receiving solvent liquid from the liquid inlet and delivering the solvent liquid to the liquid extraction tip. An open liquid extraction channel extends across an exterior surface of the probe body from the liquid extraction tip to the liquid outlet. An electrospray emitter tip is in liquid communication with the liquid outlet of the liquid extraction surface sampling probe. A system for analyzing samples, a liquid junction surface sampling system, and a method of analyzing samples are also disclosed.

  11. United Parcel Service Evaluates Hybrid Electric Delivery Vans (Fact Sheet)

    SciTech Connect (OSTI)

    Not Available

    2010-02-01

    This fact sheet describes how the National Renewable Energy Laboratory's Fleet Test and Evaluation team evaluated the 12-month, in-service performance of six Class 4 hybrid electric delivery vans - fueled by regular diesel - and six comparable conventional diesel vans operated by the United Parcel Service.

  12. TO: Honorable Patricia Hoffman, Assistant Secretary for Electricity Delivery

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Figure 1 TO: Honorable Patricia Hoffman, Assistant Secretary for Electricity Delivery and Energy Reliability, U.S. Department of Energy FROM: Electricity Advisory Committee (EAC) Richard Cowart, Chair DATE: September 30, 2015 RE: Grid Modernization: ARRA Accomplishments and Recommendations for Moving Forward ________________________________________________________________________ 1 Background and Purpose The U.S. Department of Energy (DOE)'s smart grid portion of the American Reinvestment and

  13. Comparison of Elekta VMAT with helical tomotherapy and fixed field IMRT: Plan quality, delivery efficiency and accuracy

    SciTech Connect (OSTI)

    Rao Min; Yang Wensha; Chen Fan; Sheng Ke; Ye Jinsong; Mehta, Vivek; Shepard, David; Cao Daliang

    2010-03-15

    Purpose: Helical tomotherapy (HT) and volumetric modulated arc therapy (VMAT) are arc-based approaches to IMRT delivery. The objective of this study is to compare VMAT to both HT and fixed field IMRT in terms of plan quality, delivery efficiency, and accuracy. Methods: Eighteen cases including six prostate, six head-and-neck, and six lung cases were selected for this study. IMRT plans were developed using direct machine parameter optimization in the Pinnacle{sup 3} treatment planning system. HT plans were developed using a Hi-Art II planning station. VMAT plans were generated using both the Pinnacle{sup 3} SmartArc IMRT module and a home-grown arc sequencing algorithm. VMAT and HT plans were delivered using Elekta's PreciseBeam VMAT linac control system (Elekta AB, Stockholm, Sweden) and a TomoTherapy Hi-Art II system (TomoTherapy Inc., Madison, WI), respectively. Treatment plan quality assurance (QA) for VMAT was performed using the IBA MatriXX system while an ion chamber and films were used for HT plan QA. Results: The results demonstrate that both VMAT and HT are capable of providing more uniform target doses and improved normal tissue sparing as compared with fixed field IMRT. In terms of delivery efficiency, VMAT plan deliveries on average took 2.2 min for prostate and lung cases and 4.6 min for head-and-neck cases. These values increased to 4.7 and 7.0 min for HT plans. Conclusions: Both VMAT and HT plans can be delivered accurately based on their own QA standards. Overall, VMAT was able to provide approximately a 40% reduction in treatment time while maintaining comparable plan quality to that of HT.

  14. SciFri AM: Mountain 05: Unified Optimization and Delivery of Intensity-modulated Radiation Therapy and Volume-modulated Arc Therapy

    SciTech Connect (OSTI)

    Chen, J; Hoover, D; MacFarlane, M; Wong, E

    2014-08-15

    Purpose: To study the feasibility of a unified intensity-modulated arc therapy (UIMAT) that combines IMRT and VMAT optimization and delivery in order to produce efficient and superior radiation treatment plans. Methods: Inverse planning for UIMAT was prototyped on the Pinnacle treatment planning system (Philips Medical Systems). UIMAT integrates IMRT and VMAT delivery in the same arc where IMRT was delivered with gantry speed close to zero. Optimal gantry angles for the IMRT phases were selected automatically by the inverse optimization algorithm. Optimization of the VMAT phases and IMRT phases were done simultaneously using Pinnacle's direct machine parameter optimization algorithm. Five treatment plans each for prostate, head and neck, and lung were generated using our unified technique and compared with clinical VMAT or IMRT plans. Delivery verification was performed on an ArcCheck phantom (Sun Nuclear) and delivered in clinical mode on a Varian TrueBeam linear accelerator. Results: In this prototype implementation, compared to the VMAT or IMRT plans, with the plans normalized to the same dose coverage to the planning target volumes, the UIMAT plans produced improved OAR sparing for head and neck cases, while for lung and prostate cases, the dosimetric improvements for OARs were not as significant. In this proof-of-concept work, we demonstrated that a novel radiation therapy delivery technique combining VMAT and IMRT delivery in the same arc is feasible. Initial results showed UIMAT has the potential to be superior to either standard IMRT or VMAT.

  15. Hydrogen Delivery Infrastructure Analysis, Options and Trade-offs, Transition and Long-term

    Energy.gov [DOE]

    Presentation on Hydrogen Delivery Infrastructure Analysis, Options and Trade-offs, Transition and Long-term for the DOE Hydrogen Delivery High-Pressure Tanks and Analysis Project Review Meeting held February 8-9, 2005 at Argonne National Laboratory

  16. DOE and FreedomCAR and Fuel Partnership Hydrogen Delivery and...

    Energy Savers

    DOE and FreedomCAR and Fuel Partnership Hydrogen Delivery and On-Board Storage Analysis Workshop DOE and FreedomCAR and Fuel Partnership Hydrogen Delivery and On-Board Storage ...

  17. NREL: Innovation Impact - Energy Systems Integration

    U.S. Department of Energy (DOE) all webpages (Extended Search)

    Energy Systems Integration Menu Home Home Solar Solar Wind Wind Analysis Analysis Bioenergy Bioenergy Buildings Buildings Transportation Transportation Manufacturing Manufacturing Energy Systems Integration Energy Systems Integration What is Energy Systems Integration? Close Energy systems integration (ESI) brings together the wide range of energy carriers-electricity, thermal sources, and fuels-with other infrastructures, such as water and transportation. Where most energy sources, delivery

  18. Secretary Steven Chu Remarks as Prepared for Delivery to the 2011 IAEA General Conference

    Office of Energy Efficiency and Renewable Energy (EERE)

    2011 IAEA General ConferenceRemarks as Prepared for DeliverySecretary Steven ChuMonday, September 19, 2011

  19. Overview of FreedomCAR & Fuels Partnership/DOE Delivery Program |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy FreedomCAR & Fuels Partnership/DOE Delivery Program Overview of FreedomCAR & Fuels Partnership/DOE Delivery Program Presentation on FreedomCAR & Fuells Partnership for the DOE Hydrogen Delivery High-Pressure Tanks and Analysis Project Review Meeting held February 8-9, 2005 at Argonne National Laboratory 02_parks_dtt.pdf (9.2 MB) More Documents & Publications Delivery Tech Team DOE Hydrogen Program Overview President's Hydrogen Fuel Initiative

  20. Secretary Chu's Remarks at the World Renewable Energy Forum Press Availability- As Prepared for Delivery

    Energy.gov [DOE]

    Secretary Chu's remarks, as prepared for delivery, at a press availability at the World Renewable Energy Forum in Denver, Colorado.

  1. Project Startup: Evaluating Coca-Cola's Class 8 Hybrid-Electric Delivery Trucks (Fact Sheet)

    SciTech Connect (OSTI)

    Not Available

    2011-03-01

    Fact sheet describing the project startup for evaluating Coca-Cola's Class 8 hybrid-electric delivery trucks.

  2. Advanced Technology Light Duty Diesel Aftertreatment System

    Energy.gov [DOE]

    Light duty diesel aftertreatment system consisting of a DOC and selective catalytic reduction catalyst on filter (SCRF), close coupled to the engine with direct gaseous ammonia delivery is designed to reduce cold start NOx and HC emissions

  3. Smart Grid System Report

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    August 2014 2014 Smart Grid System Report Report to Congress August 2014 United States Department of Energy Washington, DC 20585 Department of Energy | August 2014 THIS PAGE INTENTIONALLY LEFT BLANK 2014 Smart Grid System Report Department of Energy | August 2014 Message from the Assistant Secretary Office of Electricity Delivery and Energy Reliability I am pleased to present the 2014 Smart Grid System Report, which is intended to provide an update on the status of smart grid deployment

  4. FOAM: NOVEL DELIVERY TECHNOLOGY FOR REMEDIATION OF VADOSE ZONE ENVIRONMENTS

    SciTech Connect (OSTI)

    Jansik, Danielle P.; Wellman, Dawn M.; Mattigod, Shas V.; Zhong, Lirong; Wu, Yuxin; Foote, Martin; Zhang, Z. F.; Hubbard, Susan

    2011-07-05

    Deep vadose zone environments can be a primary source and pathway for contaminant migration to groundwater. These environments present unique characterization and remediation challenges that necessitate scrutiny and research. The thickness, depth, and intricacies of the deep vadose zone, combined with a lack of understanding of the key subsurface processes (e.g., biogeochemical and hydrologic) affecting contaminant migration, make it difficult to create validated conceptual and predictive models of subsurface flow dynamics and contaminant behavior across multiple scales. These factors also make it difficult to design and deploy sustainable remedial approaches and monitor long-term contaminant behavior after remedial actions. Functionally, the methods for addressing contamination must remove and/or reduce transport of contaminants. This problem is particularly challenging in the arid western United States where the vadose zone is hundreds of feet thick, rendering transitional excavation methods exceedingly costly and ineffective. Delivery of remedial amendments is one of the most challenging and critical aspects for all remedy-based approaches. The conventional approach for delivery is through injection of aqueous remedial solutions. However, heterogeneous deep vadose zone environments present hydrologic and geochemical challenges which limit the effectiveness. Because the flow of solution infiltration is dominantly controlled by gravity and suction, injected liquid preferentially percolates through highly permeable pathways, by-passing low-permeability zones which frequently contain the majority of contamination. Moreover, the wetting front can readily mobilize and enhance contaminant transport to the underlying aquifer prior to stabilization. Development of innovative, in-situ technologies may be the only way to meet remedial action objectives and long-term stewardship goals. Surfactants can be used to lower the liquid surface tension and create stabile foams

  5. Texas Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet)

    U.S. Energy Information Administration (EIA) (indexed site)

    Exports (No Intransit Deliveries) (Million Cubic Feet) Texas Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1980's 11 0 29 394 372 368 422 15,535 1990's 13,983 58,851 93,408 36,423 44,041 61,241 30,435 34,163 46,933 53,260 2000's 83,268 109,063 216,919 278,676 309,891 207,833 205,307 178,897 209,741 195,651 2010's 257,158 374,188 474,060 499,809 546,308 845,949 - = No Data Reported; -- = Not

  6. U.S. Natural Gas Interstate Deliveries (Million Cubic Feet)

    U.S. Energy Information Administration (EIA) (indexed site)

    Deliveries (Million Cubic Feet) U.S. Natural Gas Interstate Deliveries (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1980's 50,697,415 1990's 51,022,894 49,708,414 52,574,795 52,674,053 57,969,941 61,167,051 62,953,877 61,199,549 55,139,674 57,326,720 2000's 58,570,289 65,774,849 63,389,468 65,793,961 64,423,388 63,027,775 61,863,323 66,858,134 70,305,954 72,022,602 2010's 74,778,078 74,661,629 70,195,570 64,110,541 62,505,636 60,548,789 - = No

  7. Michigan Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet)

    U.S. Energy Information Administration (EIA) (indexed site)

    Exports (No Intransit Deliveries) (Million Cubic Feet) Michigan Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1980's 0 0 0 0 9,113 3,257 17,900 38,361 1990's 17,284 14,751 67,763 44,413 49,470 26,948 50,363 56,447 39,683 36,998 2000's 70,980 161,588 171,515 259,597 368,947 337,818 317,291 455,216 531,333 673,318 2010's 721,075 876,267 872,620 684,510 554,675 486,675 - = No Data Reported; -- = Not

  8. Montana Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet)

    U.S. Energy Information Administration (EIA) (indexed site)

    Exports (No Intransit Deliveries) (Million Cubic Feet) Montana Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1980's 162 136 127 178 90 40 39 82 1990's 75 41 14 106 3,087 1,510 2000's 1,606 2,978 16,036 8,889 23,379 19,159 21,245 20,420 16,399 12,504 2010's 9,437 6,826 4,332 2,353 891 35 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual

  9. Louisiana Natural Gas % of Total Residential Deliveries (Percent)

    U.S. Energy Information Administration (EIA) (indexed site)

    % of Total Residential Deliveries (Percent) Louisiana Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 1.14 1.09 1.09 1.08 1.06 1.05 0.95 2000's 1.00 1.03 1.01 0.93 0.88 0.85 0.77 0.79 0.76 0.76 2010's 0.95 0.84 0.77 0.79 0.88 0.78 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date:

  10. Maryland Natural Gas % of Total Residential Deliveries (Percent)

    U.S. Energy Information Administration (EIA) (indexed site)

    % of Total Residential Deliveries (Percent) Maryland Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 1.55 1.58 1.58 1.63 1.56 1.51 1.58 2000's 1.68 1.48 1.64 1.79 1.77 1.78 1.63 1.77 1.66 1.73 2010's 1.75 1.65 1.70 1.70 1.78 1.80 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016

  11. Massachusetts Natural Gas % of Total Residential Deliveries (Percent)

    U.S. Energy Information Administration (EIA) (indexed site)

    % of Total Residential Deliveries (Percent) Massachusetts Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 2.45 2.47 2.18 2.18 2.25 2.26 2.24 2000's 2.28 2.24 2.24 2.48 2.32 2.46 2.38 2.44 2.71 2.78 2010's 2.63 2.74 2.78 2.39 2.49 2.75 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date:

  12. Michigan Natural Gas % of Total Residential Deliveries (Percent)

    U.S. Energy Information Administration (EIA) (indexed site)

    % of Total Residential Deliveries (Percent) Michigan Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 7.46 7.52 7.84 7.62 7.62 7.07 7.42 2000's 7.36 7.20 7.52 7.59 7.44 7.43 7.23 6.95 6.99 6.84 2010's 6.36 6.75 6.67 6.82 6.97 6.77 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016

  13. Mississippi Natural Gas % of Total Residential Deliveries (Percent)

    U.S. Energy Information Administration (EIA) (indexed site)

    % of Total Residential Deliveries (Percent) Mississippi Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.57 0.56 0.56 0.58 0.55 0.55 0.52 2000's 0.54 0.59 0.54 0.52 0.50 0.51 0.49 0.47 0.49 0.49 2010's 0.57 0.52 0.47 0.51 0.56 0.50 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date:

  14. Missouri Natural Gas % of Total Residential Deliveries (Percent)

    U.S. Energy Information Administration (EIA) (indexed site)

    % of Total Residential Deliveries (Percent) Missouri Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 2.71 2.53 2.58 2.62 2.56 2.45 2.37 2000's 2.31 2.44 2.34 2.26 2.25 2.21 2.18 2.15 2.33 2.22 2010's 2.25 2.18 2.00 2.17 2.27 2.07 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016

  15. Montana Natural Gas % of Total Residential Deliveries (Percent)

    U.S. Energy Information Administration (EIA) (indexed site)

    % of Total Residential Deliveries (Percent) Montana Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.41 0.39 0.41 0.42 0.42 0.42 0.42 2000's 0.40 0.42 0.44 0.40 0.41 0.41 0.45 0.42 0.44 0.46 2010's 0.44 0.46 0.46 0.42 0.42 0.41 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016

  16. Nebraska Natural Gas % of Total Residential Deliveries (Percent)

    U.S. Energy Information Administration (EIA) (indexed site)

    % of Total Residential Deliveries (Percent) Nebraska Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.97 0.92 0.93 0.94 0.95 0.90 0.86 2000's 0.85 0.98 0.90 0.83 0.79 0.79 0.82 0.82 0.87 0.84 2010's 0.84 0.84 0.75 0.84 0.83 0.75 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016

  17. Alabama Natural Gas % of Total Electric Utility Deliveries (Percent)

    U.S. Energy Information Administration (EIA) (indexed site)

    Electric Utility Deliveries (Percent) Alabama Natural Gas % of Total Electric Utility Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.17 0.13 0.23 0.23 0.29 0.60 0.53 2000's 0.81 1.29 1.98 1.68 2.14 1.79 2.34 2.57 2.46 3.30 2010's 3.81 4.53 4.40 4.08 4.25 4.12 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016

  18. Alabama Natural Gas % of Total Residential Deliveries (Percent)

    U.S. Energy Information Administration (EIA) (indexed site)

    Residential Deliveries (Percent) Alabama Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 1.04 1.03 1.02 1.08 0.97 1.03 0.90 2000's 0.95 1.03 0.95 0.92 0.90 0.87 0.87 0.75 0.77 0.75 2010's 0.88 0.78 0.66 0.72 0.77 0.71 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring

  19. Alabama Natural Gas % of Total Vehicle Fuel Deliveries (Percent)

    U.S. Energy Information Administration (EIA) (indexed site)

    Vehicle Fuel Deliveries (Percent) Alabama Natural Gas % of Total Vehicle Fuel Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.44 0.20 0.15 0.08 0.71 0.57 0.57 2000's 0.57 0.52 0.52 0.52 0.52 0.67 0.47 0.36 0.32 0.29 2010's 0.37 0.64 0.64 0.63 1.07 1.07 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring

  20. Alabama Natural Gas Percentage Total Commercial Deliveries (Percent)

    U.S. Energy Information Administration (EIA) (indexed site)

    Commercial Deliveries (Percent) Alabama Natural Gas Percentage Total Commercial Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.90 0.88 0.87 0.92 1.01 0.86 0.91 2000's 0.80 0.87 0.80 0.80 0.85 0.84 0.86 0.78 0.80 0.78 2010's 0.87 0.80 0.74 0.77 0.79 0.78 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016

  1. Alaska Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet)

    U.S. Energy Information Administration (EIA) (indexed site)

    Exports (No Intransit Deliveries) (Million Cubic Feet) Alaska Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1980's 49,861 52,857 52,840 52,883 50,172 48,599 51,573 51,424 1990's 52,546 54,005 52,532 55,989 62,682 65,283 67,648 62,187 65,951 63,607 2000's 65,610 65,753 63,439 65,698 62,099 65,124 60,765 48,396 39,164 30,536 2010's 30,100 16,398 9,342 0 13,310 16,519 - = No Data Reported; -- = Not

  2. California Natural Gas Exports (No Intransit Deliveries) (Million Cubic

    U.S. Energy Information Administration (EIA) (indexed site)

    Feet) Exports (No Intransit Deliveries) (Million Cubic Feet) California Natural Gas Exports (No Intransit Deliveries) (Million Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1980's 0 0 0 0 0 1990's 308 2,067 3,761 2000's 13,152 23,320 35,305 53,720 80,019 89,987 101,101 96,757 109,127 101,422 2010's 43,278 94,433 110,656 107,273 120,359 124,276 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of

  3. Alaska Natural Gas % of Total Residential Deliveries (Percent)

    U.S. Energy Information Administration (EIA) (indexed site)

    % of Total Residential Deliveries (Percent) Alaska Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.28 0.31 0.31 0.31 0.30 0.35 0.37 2000's 0.32 0.35 0.33 0.33 0.37 0.37 0.47 0.42 0.44 0.42 2010's 0.39 0.43 0.52 0.39 0.35 0.40 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016

  4. Arkansas Natural Gas % of Total Residential Deliveries (Percent)

    U.S. Energy Information Administration (EIA) (indexed site)

    % of Total Residential Deliveries (Percent) Arkansas Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.92 0.86 0.85 0.88 0.85 0.85 0.77 2000's 0.85 0.78 0.80 0.75 0.71 0.70 0.72 0.69 0.73 0.70 2010's 0.76 0.72 0.63 0.71 0.75 0.72 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016

  5. California Natural Gas % of Total Residential Deliveries (Percent)

    U.S. Energy Information Administration (EIA) (indexed site)

    % of Total Residential Deliveries (Percent) California Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 10.11 10.75 9.85 9.03 9.61 12.17 12.03 2000's 10.34 10.75 10.45 9.80 10.52 10.02 11.26 10.43 10.00 10.06 2010's 10.35 10.87 11.52 9.84 7.81 8.70 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next

  6. Colorado Natural Gas % of Total Residential Deliveries (Percent)

    U.S. Energy Information Administration (EIA) (indexed site)

    % of Total Residential Deliveries (Percent) Colorado Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 2.14 2.05 2.15 2.12 2.32 2.45 2.37 2000's 2.33 2.59 2.64 2.45 2.48 2.57 2.73 2.77 2.74 2.70 2010's 2.74 2.76 2.79 2.76 2.60 2.66 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016

  7. Wyoming Natural Gas % of Total Residential Deliveries (Percent)

    U.S. Energy Information Administration (EIA) (indexed site)

    % of Total Residential Deliveries (Percent) Wyoming Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.26 0.24 0.25 0.26 0.26 0.28 0.26 2000's 0.24 0.23 0.27 0.24 0.25 0.24 0.27 0.26 0.27 0.26 2010's 0.27 0.28 0.28 0.28 0.26 0.25 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016

  8. North Dakota Natural Gas % of Total Residential Deliveries (Percent)

    U.S. Energy Information Administration (EIA) (indexed site)

    % of Total Residential Deliveries (Percent) North Dakota Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.22 0.22 0.23 0.24 0.23 0.22 0.22 2000's 0.22 0.22 0.24 0.23 0.23 0.22 0.22 0.23 0.24 0.24 2010's 0.22 0.23 0.23 0.25 0.25 0.23 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date:

  9. Ohio Natural Gas % of Total Residential Deliveries (Percent)

    U.S. Energy Information Administration (EIA) (indexed site)

    % of Total Residential Deliveries (Percent) Ohio Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 7.14 7.08 7.38 7.15 7.11 6.56 6.73 2000's 6.88 6.47 6.57 6.75 6.59 6.69 6.23 6.34 6.27 6.12 2010's 5.93 6.07 6.05 6.07 6.30 6.19 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016

  10. Oregon Natural Gas % of Total Residential Deliveries (Percent)

    U.S. Energy Information Administration (EIA) (indexed site)

    % of Total Residential Deliveries (Percent) Oregon Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.60 0.60 0.58 0.63 0.65 0.76 0.82 2000's 0.78 0.80 0.79 0.73 0.79 0.82 0.94 0.91 0.92 0.94 2010's 0.85 0.99 1.04 0.94 0.81 0.81 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016

  11. Pennsylvania Natural Gas % of Total Residential Deliveries (Percent)

    U.S. Energy Information Administration (EIA) (indexed site)

    % of Total Residential Deliveries (Percent) Pennsylvania Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 5.43 5.54 5.40 5.32 5.27 4.82 5.11 2000's 5.26 5.01 4.89 5.22 5.09 5.08 4.71 4.90 4.69 4.76 2010's 4.68 4.66 4.76 4.73 5.01 5.11 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date:

  12. Rhode Island Natural Gas % of Total Residential Deliveries (Percent)

    U.S. Energy Information Administration (EIA) (indexed site)

    % of Total Residential Deliveries (Percent) Rhode Island Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.40 0.36 0.36 0.36 0.36 0.36 0.35 2000's 0.37 0.38 0.36 0.40 0.40 0.40 0.39 0.37 0.36 0.37 2010's 0.35 0.36 0.38 0.37 0.39 0.44 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date:

  13. South Carolina Natural Gas % of Total Residential Deliveries (Percent)

    U.S. Energy Information Administration (EIA) (indexed site)

    % of Total Residential Deliveries (Percent) South Carolina Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.49 0.48 0.52 0.56 0.52 0.56 0.54 2000's 0.58 0.58 0.56 0.57 0.60 0.59 0.57 0.53 0.55 0.57 2010's 0.68 0.57 0.55 0.58 0.63 0.60 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date:

  14. South Dakota Natural Gas % of Total Residential Deliveries (Percent)

    U.S. Energy Information Administration (EIA) (indexed site)

    % of Total Residential Deliveries (Percent) South Dakota Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.25 0.25 0.26 0.27 0.27 0.26 0.25 2000's 0.25 0.26 0.26 0.26 0.25 0.25 0.26 0.26 0.28 0.28 2010's 0.27 0.27 0.26 0.28 0.28 0.26 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date:

  15. Tennessee Natural Gas % of Total Residential Deliveries (Percent)

    U.S. Energy Information Administration (EIA) (indexed site)

    % of Total Residential Deliveries (Percent) Tennessee Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 1.19 1.18 1.24 1.34 1.29 1.31 1.28 2000's 1.37 1.43 1.42 1.37 1.34 1.37 1.40 1.29 1.41 1.38 2010's 1.55 1.43 1.30 1.45 1.54 1.46 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date:

  16. Utah Natural Gas % of Total Residential Deliveries (Percent)

    U.S. Energy Information Administration (EIA) (indexed site)

    % of Total Residential Deliveries (Percent) Utah Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 1.05 1.01 1.01 1.04 1.17 1.26 1.17 2000's 1.11 1.15 1.21 1.08 1.24 1.20 1.37 1.28 1.35 1.36 2010's 1.38 1.49 1.44 1.44 1.23 1.27 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016

  17. Vermont Natural Gas % of Total Residential Deliveries (Percent)

    U.S. Energy Information Administration (EIA) (indexed site)

    % of Total Residential Deliveries (Percent) Vermont Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.05 0.05 0.05 0.05 0.05 0.05 0.05 2000's 0.06 0.06 0.06 0.06 0.06 0.06 0.07 0.07 0.06 0.07 2010's 0.06 0.07 0.07 0.07 0.08 0.08 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016

  18. West Virginia Natural Gas % of Total Residential Deliveries (Percent)

    U.S. Energy Information Administration (EIA) (indexed site)

    % of Total Residential Deliveries (Percent) West Virginia Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.71 0.73 0.73 0.71 0.72 0.66 0.67 2000's 0.63 0.67 0.63 0.63 0.62 0.62 0.60 0.56 0.56 0.55 2010's 0.57 0.53 0.54 0.54 0.56 0.54 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date:

  19. Wisconsin Natural Gas % of Total Residential Deliveries (Percent)

    U.S. Energy Information Administration (EIA) (indexed site)

    % of Total Residential Deliveries (Percent) Wisconsin Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 2.63 2.64 2.80 2.82 2.73 2.57 2.70 2000's 2.70 2.63 2.81 2.80 2.78 2.72 2.76 2.78 2.87 2.79 2010's 2.58 2.75 2.71 2.92 2.96 2.75 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date:

  20. Connecticut Natural Gas % of Total Residential Deliveries (Percent)

    U.S. Energy Information Administration (EIA) (indexed site)

    % of Total Residential Deliveries (Percent) Connecticut Natural Gas % of Total Residential Deliveries (Percent) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 0.85 0.86 0.84 0.84 0.81 0.78 0.81 2000's 0.83 0.86 0.82 0.90 0.91 0.92 0.89 0.92 0.88 0.92 2010's 0.89 0.95 0.99 0.96 1.01 1.11 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: