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Sample records for detroit mi public

  1. Detroit Public Lighting Department - Commercial and Industrial...

    Energy.gov [DOE] (indexed site)

    PublicLightingEnergyWis... Expiration Date 11302012 State Michigan Program Type Rebate Program Rebate Amount Light Fixtures: 2-130 Lighting Controls: 0.10-65...

  2. ,"Detroit, MI Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Detroit, MI Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  3. Detroit, Michigan: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Detroit, Michigan: Energy Resources (Redirected from Detroit, MI) Jump to: navigation, search Equivalent URI DBpedia Coordinates 42.331427, -83.0457538 Show Map Loading map......

  4. City of Detroit- SmartBuildings Detroit Green Fund Loan

    Office of Energy Efficiency and Renewable Energy (EERE)

    The Economic Development Corporation (EDC) of the City of Detroit is offering financial assistance to commercial, institutional and public buildings in Detroit that install energy efficiency and ...

  5. Detroit Street Lighting Report | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Detroit Street Lighting Report Detroit Street Lighting Report 2015_restoring-detroit.pdf (929.98 KB) More Documents & Publications LED Roadway Lighting OCTOBER 2015 POSTINGS Demonstration Assessment of Light Emitting Diode (LED) Street Lighting, Final Report

  6. Secretary Moniz Applauds Detroit's LED Street Lighting Upgrades |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Applauds Detroit's LED Street Lighting Upgrades Secretary Moniz Applauds Detroit's LED Street Lighting Upgrades June 16, 2014 - 10:46am Addthis Secretary of Energy Ernest Moniz visited Detroit on May 22, 2014, to mark the city's progress installing energy-efficient LED streetlights in an update of its largely broken public lighting system, speaking at the Detroit Area Pre-College Engineering Program. Like so many cities across the country, Detroit is plagued with aging

  7. DOE - Office of Legacy Management -- Dow-Detroit Edison Project...

    Office of Legacy Management (LM)

    Name: None Location: Detroit , Michigan MI.0-02-1 Evaluation Year: 1987 MI.0-02-1 Site Operations: Performed reference design work for a special fast breeder type reactor. ...

  8. Detroit Workshop Highlights

    Energy.gov [DOE]

    View the video showing highlights from the ninth annual DOE Solid-State Lighting Market Development Workshop in Detroit.

  9. American Recovery and Reinvestment Act ( ARRA) FEMP Technical Assistance, U.S. General Services Administration - Project 194 U.S. Custom Cargo Inspection Facility, Detroit, MI

    SciTech Connect

    Arends, J.; Sandusky, William F.

    2010-05-31

    This report documents the findings of an on-site audit of the U.S. Customs Cargo Inspection Facility (CIF) in Detroit, Michigan. The federal landlord for this building is the General Services Administration (GSA). The focus of the audit was to identify various no-cost or low-cost energy-efficiency opportunities that, once implemented, would reduce electrical and gas consumption and increase the operational efficiency of the building. This audit also provided an opportunity to identify potential capital cost projects that should be considered in the future to acquire additional energy (electric and gas) and water savings to further increase the operational efficiency of the building.

  10. DOE - Office of Legacy Management -- Detrex Corp - MI 10

    Office of Legacy Management (LM)

    Detroit , Michigan MI.10-1 Evaluation Year: 1987 MI.10-2 Site Operations: Conducted experimental runs relative to picklingdegreasing of one handful of uranium turnings MI.10-1...

  11. Restoring Detroit's Street Lighting System

    SciTech Connect

    Kinzey, Bruce R.

    2015-10-21

    The City of Detroit is undertaking a comprehensive restoration of its street lighting system that includes transitioning the existing high-pressure sodium (HPS) sources to light-emitting diode (LED). Detroit’s well-publicized financial troubles over the last several years have added many hurdles and constraints to this process. Strategies to overcome these issues have largely been successful, but have also brought some mixed results. This document provides an objective review of the circumstances surrounding the system restoration, the processes undertaken and decisions made, and the results so far.

  12. SEP Success Story: Detroit Diesel

    Energy.gov [DOE]

    This video features Detroit Diesel’s success with DOE’s Superior Energy Performance® (SEP™) program. Daimler’s Detroit Diesel Corporation facility earned Platinum SEP certification in November 2015...

  13. Detroit, MI Natural Gas Exports to Canada

    Energy Information Administration (EIA) (indexed site)

    2010 2011 2012 2013 2014 2015 View History Pipeline Volumes 79 19 0 165 188 0 1996-2015 Pipeline Prices 8.37 5.17 -- 4.44 5.26 -- 1996

  14. Detroit, MI Natural Gas Exports to Canada

    Energy Information Administration (EIA) (indexed site)

    275 43,690 50,347 50,439 46,981 37,528 1996-2015 Pipeline Prices 4.69 4.26 3.10 4.04 5.36 2.91

  15. Ricardo Detroit Technical Center | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Ricardo Detroit Technical Center Jump to: navigation, search Name: Ricardo Detroit Technical Center Place: Van Buren Township, Michigan Zip: 48111-1641 Sector: Services Product:...

  16. Detroit Auto Show 2012 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Detroit Auto Show 2012 Detroit Auto Show 2012 Addthis 1 of 10 Energy Secretary Steven Chu with Chrysler Chief Executive Sergio Marchionne. Image: Hantz Leger (Energy Department ...

  17. Detroit Commuter Hydrogen Project

    SciTech Connect

    Brooks, Jerry; Prebo, Brendan

    2010-07-31

    This project was undertaken to demonstrate the viability of using hydrogen as a fuel in an internal combustion engine vehicle for use as a part of a mass transit system. The advantages of hydrogen as a fuel include renew-ability, minimal environmental impact on air quality and the environment, and potential to reduce dependence on foreign energy sources for the transportation sector. Recognizing the potential for the hydrogen fuel concept, the Southeast Michigan Congress of Governments (SEMCOG) determined to consider it in the study of a proposed regional mass transit rail system for southeast Michigan. SEMCOG wanted to evaluate the feasibility of using hydrogen fueled internal combustion engine (H2ICE) vehicles in shuttle buses to connect the Detroit Metro Airport to a proposed, nearby rail station. Shuttle buses are in current use on the airport for passenger parking and inter-terminal transport. This duty cycle is well suited to the application of hydrogen fuel at this time because of the ability to re-fuel vehicles at a single nearby facility, overcoming the challenge of restricted fuel availability in the undeveloped hydrogen fuel infrastructure. A cooperative agreement between SEMCOG and the DOE was initiated and two H2ICE buses were placed in regular passenger service on March 29, 2009 and operated for six months in regular passenger service. The buses were developed and built by the Ford Motor Company. Wayne County Airport Authority provided the location for the demonstration with the airport transportation contractor, Metro Cars Inc. operating the buses. The buses were built on Ford E450 chassis and incorporated a modified a 6.8L V-10 engine with specially designed supercharger, fuel rails and injectors among other sophisticated control systems. Up to 30 kg of on-board gaseous hydrogen were stored in a modular six tank, 350 bar (5000 psi) system to provide a 150 mile driving range. The bus chassis and body were configured to carry nine passengers with

  18. TEXT-ALTERNATIVE VERSION: DETROIT WORKSHOP HIGHLIGHTS

    Energy.gov [DOE]

    Mayor Mike Duggan, City of Detroit: The DOE has just been an outstanding partner, and I'm really glad to be welcoming you here at this time. So welcome to Detroit.

  19. Detroit, Michigan: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Detroit, Michigan: Energy Resources Jump to: navigation, search Equivalent URI DBpedia Coordinates 42.331427, -83.0457538 Show Map Loading map... "minzoom":false,"mappingservi...

  20. City of Detroit Lakes, Minnesota (Utility Company) | Open Energy...

    OpenEI (Open Energy Information) [EERE & EIA]

    Lakes, Minnesota (Utility Company) Jump to: navigation, search Name: City of Detroit Lakes Place: Minnesota Website: www.ci.detroit-lakes.mn.usmai Facebook: https:...

  1. PP-221 Detroit Edison Company | Department of Energy

    Energy.gov [DOE] (indexed site)

    Permit authorizing Detroit Edison Company to construct, operate and maintain electric transmission facilities at the U.S. - Canada border. PDF icon PP-221 Detroit.pdf More ...

  2. Economic Potential of CHP in Detroit Edison Service Area: The...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Economic Potential of CHP in Detroit Edison Service Area: The Customer Perspective, June 2003 Economic Potential of CHP in Detroit Edison Service Area: The Customer Perspective, ...

  3. City of Detroit (Michigan) EIA Revenue and Sales - February 2008...

    OpenEI (Open Energy Information) [EERE & EIA]

    City of Detroit (Michigan) EIA Revenue and Sales - February 2008 Jump to: navigation, search EIA Monthly Electric Utility Sales and Revenue Data for City of Detroit for February...

  4. City of Detroit (Michigan) EIA Revenue and Sales - May 2008 ...

    OpenEI (Open Energy Information) [EERE & EIA]

    Detroit (Michigan) EIA Revenue and Sales - May 2008 Jump to: navigation, search EIA Monthly Electric Utility Sales and Revenue Data for City of Detroit for May 2008. Monthly...

  5. City of Detroit (Michigan) EIA Revenue and Sales - February 2009...

    OpenEI (Open Energy Information) [EERE & EIA]

    City of Detroit for February 2009. Monthly Electric Utility Sales and Revenue Data Short Name 2009-02 Utility Company City of Detroit (Michigan) Place Michigan Start Date...

  6. City of Detroit (Michigan) EIA Revenue and Sales - November 2008...

    OpenEI (Open Energy Information) [EERE & EIA]

    City of Detroit (Michigan) EIA Revenue and Sales - November 2008 Jump to: navigation, search EIA Monthly Electric Utility Sales and Revenue Data for City of Detroit for November...

  7. City of Detroit (Michigan) EIA Revenue and Sales - December 2008...

    OpenEI (Open Energy Information) [EERE & EIA]

    City of Detroit for December 2008. Monthly Electric Utility Sales and Revenue Data Short Name 2008-12 Utility Company City of Detroit (Michigan) Place Michigan Start Date...

  8. SEP Case Study Webinar: Detroit Diesel Slides

    Energy.gov [DOE]

    This page contains the presentation slides from the Superior Energy Performance (SEP) Measurement and Verification Case Study webinar on Detroit Diesel hosted on July 14, 2016. This webinar...

  9. SmartBuildings Detroit Commercial Case Study

    Energy.gov [DOE]

    SmartBuildings Detroit Commercial Case Study, a document from BetterBuildings for Michigan posted on the website of the U.S. Department of Energy's Better Buildings Neighborhood Program.

  10. Detroit, MI Natural Gas Pipeline Imports From Canada (Million...

    Energy Information Administration (EIA) (indexed site)

    Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 8 11 2013 16 140 24 10 2014 188 - No Data Reported; -- Not Applicable; NA Not Available; W Withheld to avoid ...

  11. Detroit, MI Natural Gas Pipeline Exports to Canada (Million Cubic...

    Energy Information Administration (EIA) (indexed site)

    Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 30,410 31,080 24,908 25,049 2000's 36,007 35,644 7,431 19,737 40,030 40,255 22,156 22,904 27,220 ...

  12. Detroit, MI Natural Gas Pipeline Imports From Canada (Million...

    Energy Information Administration (EIA) (indexed site)

    Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 14,901 11,501 10,925 7,671 2000's 6,171 405 1,948 2,514 1,117 0 0 81 753 21 2010's 79 19 0 165

  13. Detroit, MI Natural Gas Pipeline Exports to Canada (Million Cubic...

    Energy Information Administration (EIA) (indexed site)

    Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 3,465 2,693 3,676 3,988 3,357 3,437 765 3,916 4,318 4,473 4,851 4,752 2012 5,562 5,372 5,253 3,745 3,354 2,811 2,935 3,822 ...

  14. A Look Inside the Detroit Auto Show | Department of Energy

    Energy Saver

    the Detroit Auto Show A Look Inside the Detroit Auto Show January 12, 2011 - 1:15pm Addthis Kerry Duggan Kerry Duggan Waking up at 4:30AM is not my idea of fun. But after I ...

  15. City of Detroit (Michigan) EIA Revenue and Sales - June 2008...

    OpenEI (Open Energy Information) [EERE & EIA]

    City of Detroit for June 2008. Monthly Electric Utility Sales and Revenue Data Short Name 2008-06 Utility Company City of Detroit (Michigan) Place Michigan Start Date 2008-06-01...

  16. City of Detroit (Michigan) EIA Revenue and Sales - August 2008...

    OpenEI (Open Energy Information) [EERE & EIA]

    City of Detroit for August 2008. Monthly Electric Utility Sales and Revenue Data Short Name 2008-08 Utility Company City of Detroit (Michigan) Place Michigan Start Date 2008-08-01...

  17. Secretary Chu's Remarks at Detroit Economic Club -- As Prepared for

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Delivery | Department of Energy Detroit Economic Club -- As Prepared for Delivery Secretary Chu's Remarks at Detroit Economic Club -- As Prepared for Delivery January 11, 2012 - 9:30am Addthis Thank you, President Simon, for the introduction. I also want to thank the Detroit Economic Club for hosting me. For more than 75 years, the Detroit Economic Club has promoted thoughtful conversation on the important issues facing Michigan and our country, and I am pleased to be a part of that

  18. The Detroit Edison Company Smart Grid Demonstration Project ...

    OpenEI (Open Energy Information) [EERE & EIA]

    based in Detroit, Michigan. Overview Demonstrate the use and benefits of Community Energy Storage (CES) systems for utilities and test the ability to integrate secondary-use...

  19. Detroit Beach, Michigan: Energy Resources | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Detroit Beach, Michigan: Energy Resources Jump to: navigation, search Equivalent URI DBpedia Coordinates 41.9311563, -83.3268753 Show Map Loading map... "minzoom":false,"mappi...

  20. SEP Success Story: Detroit Diesel | Department of Energy

    Office of Environmental Management (EM)

    This video features Detroit Diesel's success with DOE's Superior Energy Performance ... SEP certification in November 2015. The video describes how the automotive manufacturer ...

  1. City of Detroit (Michigan) EIA Revenue and Sales - January 2009...

    OpenEI (Open Energy Information) [EERE & EIA]

    January 2009 Jump to: navigation, search EIA Monthly Electric Utility Sales and Revenue Data for City of Detroit for January 2009. Monthly Electric Utility Sales and Revenue Data...

  2. City of Detroit (Michigan) EIA Revenue and Sales - January 2008...

    OpenEI (Open Energy Information) [EERE & EIA]

    January 2008 Jump to: navigation, search EIA Monthly Electric Utility Sales and Revenue Data for City of Detroit for January 2008. Monthly Electric Utility Sales and Revenue Data...

  3. City of Detroit (Michigan) EIA Revenue and Sales - July 2008...

    OpenEI (Open Energy Information) [EERE & EIA]

    July 2008 Jump to: navigation, search EIA Monthly Electric Utility Sales and Revenue Data for City of Detroit for July 2008. Monthly Electric Utility Sales and Revenue Data Short...

  4. City of Detroit (Michigan) EIA Revenue and Sales - March 2009...

    OpenEI (Open Energy Information) [EERE & EIA]

    9 Jump to: navigation, search EIA Monthly Electric Utility Sales and Revenue Data for City of Detroit for March 2009. Monthly Electric Utility Sales and Revenue Data Short Name...

  5. City of Detroit (Michigan) EIA Revenue and Sales - March 2008...

    OpenEI (Open Energy Information) [EERE & EIA]

    March 2008 Jump to: navigation, search EIA Monthly Electric Utility Sales and Revenue Data for City of Detroit for March 2008. Monthly Electric Utility Sales and Revenue Data Short...

  6. City of Detroit (Michigan) EIA Revenue and Sales - April 2008...

    OpenEI (Open Energy Information) [EERE & EIA]

    April 2008 Jump to: navigation, search EIA Monthly Electric Utility Sales and Revenue Data for City of Detroit for April 2008. Monthly Electric Utility Sales and Revenue Data Short...

  7. Superior Energy Performance Webinar: Detroit Diesel SEP Success, July 14,

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    2PM eastern time | Department of Energy Technical Assistance » Superior Energy Performance » Superior Energy Performance Webinar: Detroit Diesel SEP Success, July 14, 2PM eastern time Superior Energy Performance Webinar: Detroit Diesel SEP Success, July 14, 2PM eastern time July 6, 2016 - 2:13pm Addthis The DOE Advanced Manufacturing Office (AMO) is pleased to announce the fourth webinar in its series highlighting U.S. manufacturing facilities that have achieved Superior Energy Performance

  8. Health-hazard evaluation report HETA 84-484-1754, Detroit Fire Fighters, Detroit, Michigan

    SciTech Connect

    Anderson, K.E.; Melius, J.M.

    1986-12-01

    In response to a request from the International Association of Fire Fighters on behalf of the Detroit Fire Fighters Association, Detroit, Michigan, a health hazard evaluation was made of respiratory symptoms and skin irritation in fire fighters involved in a large fire and explosion at a warehouse. Over 200 fire fighters from fire-fighting organizations in three communities were involved in the incident. Site runoff water contained chlordane and malathion in low parts per million; other samples were negative. Nose and throat irritation, cough, and shortness of breath were experienced by a large proportion of fire fighters following the fire, and in 14, 15, and 17 percent, respectively, symptoms persisted over 2 months. Symptoms were significantly associated with time spent at the scene and time spent in heavy smoke. Pulmonary function tests were abnormal in 14 cases, ten due to obstructive lung disease, three to restrictive lung disease, and one to a combination. The authors conclude that better protective equipment is needed for fire fighters at chemical fires. Recommendations include development of a hazardous-materials response team, and implementation of a routine medical surveillance program.

  9. The Office of Minority Economic Impact (MI) was established in Fiscal Year 1979 pursuant to Section 641 Title V1, Part 3 of the National Energy Conservation Policy Act (Public Law 95-619), dated November 9, 1978

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Minority Economic Impact (MI) was established in Fiscal Year 1979 pursuant to Section 641 Title V1, Part 3 of the National Energy Conservation Policy Act (Public Law 95- 619), dated November 9, 1978. The following is MI's legislative mandate. PART 3 - - MINORITY ECONOMIC IMPACT SEC. 641. MINORITY ECONOMIC IMPACT. "(a) Establishment of Office of Minority Economic Impact -- Title II of the Department of Energy Organization Act (42 U.S.C. 7131 - - 7139) is amended by adding at the end thereof

  10. Detroit, MI Natural Gas Pipeline Exports to Canada (Dollars per Thousand

    Energy Information Administration (EIA) (indexed site)

    Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 2.36 2.55 2.26 2.30 2000's 3.74 4.57 3.03 5.47 6.47 8.12 7.61 6.88 8.37 4.01 2010's 4.69 4.26 3.10 4.04 5.36 2.91

  11. Detroit, MI Natural Gas Pipeline Exports to Canada (Dollars per Thousand

    Energy Information Administration (EIA) (indexed site)

    Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 4.72 4.58 4.22 4.51 4.66 4.73 4.55 4.45 4.19 3.92 3.79 3.60 2012 3.14 2.95 2.61 2.33 2.50 2.62 3.08 3.12 2.99 3.41 4.13 3.90 2013 4.04 3.67 3.96 4.42 4.42 4.26 4.02 3.84 3.90 3.89 3.79 4.34 2014 5.67 10.21 7.89 4.89 4.93 4.86 4.44 4.06 4.14 4.11 4.20 4.16 2015 3.38 3.80 3.19 2.77 2.78 2.94 2.97 3.07 2.91 2.71 2.22 2.24 2016 2.50 2.25 1.86 1.92 1.91 2.31 2.96 2.85

  12. Detroit, MI Natural Gas Pipeline Exports to Canada (Million Cubic Feet)

    Energy Information Administration (EIA) (indexed site)

    Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 3,465 2,693 3,676 3,988 3,357 3,437 765 3,916 4,318 4,473 4,851 4,752 2012 5,562 5,372 5,253 3,745 3,354 2,811 2,935 3,822 4,015 4,113 4,636 4,728 2013 4,791 4,331 4,801 3,571 4,430 3,769 3,933 4,131 3,885 2,862 3,886 4,945 2014 4,042 4,259 4,171 3,540 3,852 4,008 3,643 3,461 3,414 4,013 3,800 4,779 2015 3,753 2,420 4,176 2,416 2,035 1,911 2,624 2,674 4,755 4,944 3,048 2,773 2016 2,881 2,701 3,427 1,402 1,301 2,806 2,190 2,324

  13. Detroit, MI Natural Gas Pipeline Imports From Canada (Dollars per Thousand

    Energy Information Administration (EIA) (indexed site)

    Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 2.75 2.51 2.43 2.51 2000's 3.82 9.34 3.56 5.96 6.27 -- -- 8.28 6.58 4.53 2010's 8.37 5.17 -- 4.44 5.26 --

  14. Detroit, MI Natural Gas Pipeline Imports From Canada (Dollars per Thousand

    Energy Information Administration (EIA) (indexed site)

    Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 4.95 5.33 2013 3.80 4.50 4.09 4.63 2014 5.26

  15. Detroit, MI Natural Gas Pipeline Imports From Canada (Million Cubic Feet)

    Energy Information Administration (EIA) (indexed site)

    Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 8 11 2013 16 140 24 10 2014 188

  16. Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    publications Publications JLF Science Publications JLF Facility-related Publications JLF Highlights

  17. Daimler's Detroit Diesel Plant Earns Superior Energy Performance, Saves $37M

    Energy.gov [DOE]

    Daimler’s Detroit Diesel Corporation facility has earned Platinum certification in the U.S. Department of Energy’s (DOE’s) Superior Energy Performance® (SEP™) program. The facility used a rigorous...

  18. Detroit Edison's Fermi 1 - Preparation for Reactor Removal

    SciTech Connect

    Swindle, Danny [Sargent and Lundy Engineers, LLC, 55 E. Monroe Street, Chicago, IL 60603 (United States)

    2008-01-15

    This paper is intended to provide information about the ongoing decommissioning tasks at Detroit Edison's Fermi 1 plant, and in particular, the work being performed to prepare the reactor for removal and disposal. In 1972 Fermi 1 was shutdown and the fuel returned to the Atomic Energy Commission. By the end of 1975, a retirement plan was prepared, the bulk sodium removed, and the plant placed in a safe store condition. The plant systems were left isolated with the sodium containing systems inert with carbon dioxide in an attempt to form a carbonate layer, thus passivating the underlying reactive sodium. In 1996, Detroit Edison determined to evaluate the condition of the plant and to make recommendations in relation to the Fermi 1 future plans. At the end of 1997 approval was obtained to remove the bulk asbestos and residual alkali-metals (i.e., sodium and sodium potassium (NaK)). In 2000, full nuclear decommissioning of the plant was approved. To date, the bulk asbestos insulation has been removed, and the only NaK remaining is located in six capillary instrument tubes. The remaining sodium is contained within the reactor, two of the three primary loops, and miscellaneous removed pipes and equipment to be processed. The preferred method for removing or reacting sodium at Fermi 1 is by injecting superheated steam into a heated, nitrogen inert system. The byproducts of this reaction are caustic sodium hydroxide, hydrogen gas, and heat. The decision was made to separate the three primary loops from the reactor for better control prior to processing each loop and the reactor separately. The first loop has already been processed. The main focus is now to process the reactor to allow removal and disposal of the Class C waste prior to the anticipated June 2008 closure of the Barnwell radioactive waste disposal facility located in South Carolina. Lessons learnt are summarized and concern: the realistic schedule and adherence to the schedule, time estimates, personnel

  19. Measurement of the direct <mi>CP> -violating parameter <mi>Ami><mi>CP> in the decay <mi>D>+<mi>Kmi>-<mimi>+<mi>π>+

    SciTech Connect

    Abazov, V. M.; Abbott, B.; Acharya, B. S.; Adams, M.; Adams, T.; Agnew, J. P.; Alexeev, G. D.; Alkhazov, G.; Alton, A.; Askew, A.; Atkins, S.; Augsten, K.; Avila, C.; Badaud, F.; Bagby, L.; Baldin, B.; Bandurin, D. V.; Banerjee, S.; Barberis, E.; Baringer, P.; Bartlett, J. F.; Bassler, U.; Bazterra, V.; Bean, A.; Begalli, M.; Bellantoni, L.; Beri, S. B.; Bernardi, G.; Bernhard, R.; Bertram, I.; Besançon, M.; Beuselinck, R.; Bhat, P. C.; Bhatia, S.; Bhatnagar, V.; Blazey, G.; Blessing, S.; Bloom, K.; Boehnlein, A.; Boline, D.; Boos, E. E.; Borissov, G.; Borysova, M.; Brandt, A.; Brandt, O.; Brock, R.; Bross, A.; Brown, D.; Bu, X. B.; Buehler, M.; Buescher, V.; Bunichev, V.; Burdin, S.; Buszello, C. P.; Camacho-Pérez, E.; Casey, B. C. K.; Castilla-Valdez, H.; Caughron, S.; Chakrabarti, S.; Chan, K. M.; Chandra, A.; Chapon, E.; Chen, G.; Cho, S. W.; Choi, S.; Choudhary, B.; Cihangir, S.; Claes, D.; Clutter, J.; Cooke, M.; Cooper, W. E.; Corcoran, M.; Couderc, F.; Cousinou, M. -C.; Cutts, D.; Das, A.; Davies, G.; de Jong, S. J.; De La Cruz-Burelo, E.; Déliot, F.; Demina, R.; Denisov, D.; Denisov, S. P.; Desai, S.; Deterre, C.; DeVaughan, K.; Diehl, H. T.; Diesburg, M.; Ding, P. F.; Dominguez, A.; Dubey, A.; Dudko, L. V.; Duperrin, A.; Dutt, S.; Eads, M.; Edmunds, D.; Ellison, J.; Elvira, V. D.; Enari, Y.; Evans, H.; Evdokimov, V. N.; Fauré, A.; Feng, L.; Ferbel, T.; Fiedler, F.; Filthaut, F.; Fisher, W.; Fisk, H. E.; Fortner, M.; Fox, H.; Fuess, S.; Garbincius, P. H.; Garcia-Bellido, A.; García-González, J. A.; Gavrilov, V.; Geng, W.; Gerber, C. E.; Gershtein, Y.; Ginther, G.; Gogota, O.; Golovanov, G.; Grannis, P. D.; Greder, S.; Greenlee, H.; Grenier, G.; Gris, Ph.; Grivaz, J. -F.; Grohsjean, A.; Grünendahl, S.; Grünewald, M. W.; Guillemin, T.; Gutierrez, G.; Gutierrez, P.; Haley, J.; Han, L.; Harder, K.; Harel, A.; Hauptman, J. M.; Hays, J.; Head, T.; Hebbeker, T.; Hedin, D.; Hegab, H.; Heinson, A. P.; Heintz, U.; Hensel, C.; Heredia-De La Cruz, I.; Herner, K.; Hesketh, G.; Hildreth, M. D.; Hirosky, R.; Hoang, T.; Hobbs, J. D.; Hoeneisen, B.; Hogan, J.; Hohlfeld, M.; Holzbauer, J. L.; Howley, I.; Hubacek, Z.; Hynek, V.; Iashvili, I.; Ilchenko, Y.; Illingworth, R.; Ito, A. S.; Jabeen, S.; Jaffré, M.; Jayasinghe, A.; Jeong, M. S.; Jesik, R.; Jiang, P.; Johns, K.; Johnson, E.; Johnson, M.; Jonckheere, A.; Jonsson, P.; Joshi, J.; Jung, A. W.; Juste, A.; Kajfasz, E.; Karmanov, D.; Katsanos, I.; Kaur, M.; Kehoe, R.; Kermiche, S.; Khalatyan, N.; Khanov, A.; Kharchilava, A.; Kharzheev, Y. N.; Kiselevich, I.; Kohli, J. M.; Kozelov, A. V.; Kraus, J.; Kumar, A.; Kupco, A.; Kurča, T.; Kuzmin, V. A.; Lammers, S.; Lebrun, P.; Lee, H. S.; Lee, S. W.; Lee, W. M.; Lei, X.; Lellouch, J.; Li, D.; Li, H.; Li, L.; Li, Q. Z.; Lim, J. K.; Lincoln, D.; Linnemann, J.; Lipaev, V. V.; Lipton, R.; Liu, H.; Liu, Y.; Lobodenko, A.; Lokajicek, M.; Lopes de Sa, R.; Luna-Garcia, R.; Lyon, A. L.; Maciel, A. K. A.; Madar, R.; Magaña-Villalba, R.; Malik, S.; Malyshev, V. L.; Mansour, J.; Martínez-Ortega, J.; McCarthy, R.; McGivern, C. L.; Meijer, M. M.; Melnitchouk, A.; Menezes, D.; Mercadante, P. G.; Merkin, M.; Meyer, A.; Meyer, J.; Miconi, F.; Mondal, N. K.; Mulhearn, M.; Nagy, E.; Narain, M.; Nayyar, R.; Neal, H. A.; Negret, J. P.; Neustroev, P.; Nguyen, H. T.; Nunnemann, T.; Orduna, J.; Osman, N.; Osta, J.; Pal, A.; Parashar, N.; Parihar, V.; Park, S. K.; Partridge, R.; Parua, N.; Patwa, A.; Penning, B.; Perfilov, M.; Peters, Y.; Petridis, K.; Petrillo, G.; Pétroff, P.; Pleier, M. -A.; Podstavkov, V. M.; Popov, A. V.; Prewitt, M.; Price, D.; Prokopenko, N.; Qian, J.; Quadt, A.; Quinn, B.; Ratoff, P. N.; Razumov, I.; Ripp-Baudot, I.; Rizatdinova, F.; Rominsky, M.; Ross, A.; Royon, C.; Rubinov, P.; Ruchti, R.; Sajot, G.; Sánchez-Hernández, A.; Sanders, M. P.; Santos, A. S.; Savage, G.; Savitskyi, M.; Sawyer, L.; Scanlon, T.; Schamberger, R. D.; Scheglov, Y.; Schellman, H.; Schwanenberger, C.; Schwienhorst, R.; Sekaric, J.; Severini, H.; Shabalina, E.; Shary, V.; Shaw, S.; Shchukin, A. A.; Simak, V.; Skubic, P.; Slattery, P.; Smirnov, D.; Snow, G. R.; Snow, J.; Snyder, S.; Söldner-Rembold, S.; Sonnenschein, L.; Soustruznik, K.; Stark, J.; Stoyanova, D. A.; Strauss, M.; Suter, L.; Svoisky, P.; Titov, M.; Tokmenin, V. V.; Tsai, Y. -T.; Tsybychev, D.; Tuchming, B.; Tully, C.; Uvarov, L.; Uvarov, S.; Uzunyan, S.; Van Kooten, R.; van Leeuwen, W. M.; Varelas, N.; Varnes, E. W.; Vasilyev, I. A.; Verkheev, A. Y.; Vertogradov, L. S.; Verzocchi, M.; Vesterinen, M.; Vilanova, D.; Vokac, P.; Wahl, H. D.; Wang, M. H. L. S.; Warchol, J.; Watts, G.; Wayne, M.; Weichert, J.; Welty-Rieger, L.; Williams, M. R. J.; Wilson, G. W.; Wobisch, M.; Wood, D. R.; Wyatt, T. R.; Xie, Y.; Yamada, R.; Yang, S.; Yasuda, T.; Yatsunenko, Y. A.; Ye, W.; Ye, Z.; Yin, H.; Yip, K.; Youn, S. W.; Yu, J. M.; Zennamo, J.; Zhao, T. G.; Zhou, B.; Zhu, J.; Zielinski, M.; Zieminska, D.; Zivkovic, L.

    2014-12-01

    We measure the direct mi>Cmi>mi>P>-violating parameter mi>Ami>mi>Cmi>mi>Pmi> for the decay of the charged charm meson, mi>Dmi>+mi>Kmi>-mi>πmi>+mi>πmi>+ (and charge conjugate), using the full 10.4 mi>fbmi>-1 sample of mi>p>mi>p>¯ collisions at mi>smi>=1.96 mi>TeVmi> collected by the D0 detector at the Fermilab Tevatron collider. We extract the raw reconstructed charge asymmetry by fitting the invariant mass distributions for the sum and difference of charge-specific samples. This quantity is then corrected for detector-related asymmetries using data-driven methods and for possible physics asymmetries (from mi>B>mi>D

  20. Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    PADSTE » ADTSC » Publications Publications The Theory, Simulation, and Computation Science Highlight publications are available online. Contact Communications Email Covers from research highlight publications Covers from the print version of past Theory, Simulation, and Computation science highlights. All Theory, Simulation, and Computation technical papers, journal articles, and publications other than Science Highlights are available in the Research Library Catalog. Science Highlights 2013

  1. Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    work. Today at Berkeley Lab: : The daily newsletter for our employees and collaborators. Publications.lbl.gov: : Over 75,000 of our laboratory's scientific publications,...

  2. MINOS Experiment and NuMI Beam Home Page

    U.S. Department of Energy (DOE) - all webpages

    NuMI-MINOS Neutrino Logo NuMI Beamline and MINOS Experiment Neutrino Logo The MINOS Experiment and NuMI Beamline Fermilab Logo MINOS Experiment Links ◊ MINOS for the Public ◊ Scientific Results ◊ MINOS at Work ◊ NuMI at Work ◊ MINOS+ Experiment Fermilab Neutrino Links ◊ Neutrino FAQ ◊ MINOS Underground Areas at Fermilab ◊ PPD Intensity Frontier Dept Back to - - - ◊ Fermilab at Work ◊ Fermilab Home the MINOS Far Detector in the Soudan Mine MINOS collaborators assembling the

  3. Selected Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    publications

  4. Selected Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    publications /

  5. Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications Engineering Institute Publications Publications are organized by topic. Contact Institute Director Charles Farrar (505) 663-5330 Email UCSD EI Director Michael Todd (858) 534-5951 Professional Staff Assistant Ellie Vigil (505) 667-2818 Email Administrative Assistant Rebecca Duran (505) 665-8899 Email Model Verification and Validation Sensor and Sensing Technologies Structural Health Monitoring Earthquake Engineering and Structural Dynamics Damage Prognosis Other Publications Book

  6. Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications Publications Los Alamos publications demonstrate the Lab's enduring commitment to researching and applying the best science, engineering and technology in order to meet the challenges facing our country and society in the 21st century. NEW ISSUE: 1663 JULY 2016 July 2016 The Brief Lives of Neutrons Turmoil at the Top of the World Not Magic...Quantum Breaking the Bond Ripples in Space and Time Small Fusion Could be Huge Muon Mission in Tuscany NSS Magazine National Security Science

  7. Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications Publications The Burst Buffer Early User program has resulted in several publications, posters and talks. For reference, we list them here. "Accelerating Science with the NERSC Burst Buffer", W. Bhimji, Cray User Group (CUG) 2016 (Best Paper award) "Accelerating Science with the NERSC Burst Buffer", D. Bard, Salishan Conference on High-Speed Computing 2016 "Data Elevator: Low-contention Data Movement in Hierarchical Storage System", Bin Dong, Suren

  8. Rotary engine design: Analysis and developments; Proceedings of the International Congress and Exposition, Detroit, MI, Feb. 27-Mar. 3, 1989

    SciTech Connect

    Not Available

    1989-01-01

    The present conference on the development status of Wankel cycle rotary engine design discusses stratified-charge rotary engine features, techniques for noise and vibration reduction in rotary engines, testing methods for insulated rotary engine components, cyclic combustion variation in rotary engines, and a combustion model for homogeneous charge natural gas rotary engines. Also discussed are fuel-air mixing and distribution in a direct-injection stratified-charge rotary engine, the 'rotary-vee' engine design concept, strain measurements in a rotary engine housing, and a comparison of computed and measured pressure in a premixed-charge natural gas-fueled rotary engine.

  9. DTE Energy Technologies With Detroit Edison Co. and Kinectrics Inc.: Distributed Resources Aggregation Modeling and Field Configuration Testing

    SciTech Connect

    Not Available

    2003-10-01

    Summarizes the work of DTE Energy Technologies, Detroit Edison, and Kinectrics, under contract to DOE's Distribution and Interconnection R&D, to develop distributed resources aggregation modeling and field configuration testing.

  10. Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications Publications Official releases of Richard P. Feynman Center for Innovation publications General Inquiries Richard P. Feynman Center for Innovation (505) 665-9090 Email All years denote Fiscal Years. Progress Report FY15 FCI Progress Report 2015 (pdf) 2014 (pdf) 2013 (pdf) 2011-2012 (pdf) 2009-2010 (pdf) 2007-2008 (pdf) 2005-2006 (pdf) 2004 (pdf) outSTANDING innOVATION Awards After 2011, the outSTANDING innOVATION Awards booklet and Progress Report were combined into a single

  11. Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    GCPCC's collaboration and publication policy Beamline acknowledgement Publication List Please contact us when you have a publication resulting from work done at the GCPCC PX beamline. Miller MD, Phillips GN Jr., White MA, Fox RO, Craft BC III The development of the GCPCC Protein Crystallography Beamline at CAMD. Application of Accelerators in Research and Industry -- Sixteenth Int'l Conf., J.L. Duggan and I.L. Morgan eds., 734-737 (2001). {PDF} Qiu C, Tarrant MK, Choi SH, Sathyamurthy A, Bose R,

  12. Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Book Chapters and Other Publications Book Chapters and Other Publications Contact Institute Director Charles Farrar (505) 663-5330 Email UCSD EI Director Michael Todd (858) 534-5951 Professional Staff Assistant Ellie Vigil (505) 667-2818 Email Administrative Assistant Rebecca Duran (505) 665-8899 Email Book Chapters C. J. Stull, F. M. Hemez and C. R. Farrar, "On Assessing the Robustness of Structural Health Monitoring Technologies," Topics in Model Validation and Uncertainty

  13. Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications Publications To disseminate its innovations, Los Alamos publishes in journals and other documents worldwide. Ali, A N, M M Sandstrom, D M Oschwald, K M Moore, and S F Son. "Laser Ignition of DAAF, DHT and DAATO3.5." Propellants, Explosives, Pyrotechnics 30, no. 5 (2005): 351-355. doi:10.1002/prep.200500025. Arrowsmith, Stephen J, and Steven R Taylor. "Multivariate Acoustic Detection of Small Explosions Using Fisher's Combined Probability Test." Journal of the

  14. Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications Year 2013 Katla Sai Krishna, Pilarisetty Tarakeshwar, Vladimiro Mujica, and Challa S. S. R. Kumar, Chemically Induced Magnetism in Atomically Precise Gold Clusters, Small, 2013, accepted. Katla Sai Krishna, Challa S. S. R. Kumar, Lab-on-a-chip synthesis of inorganic nanomaterials and quantum dots for biomedical applications, Adv. Drug. Del. Rev., 2013, accepted. Jing Liu, Katla Sai Krishna, Yaroslov. B. Losovyj, Soma Chattopadhyaya, Natalia Lozova, Jeffrey T Miller, James J. Spivey,

  15. Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Damage Prognosis Publications-Damage Prognosis Journal articles for the topic Damage Prognosis. Contact Institute Director Charles Farrar (505) 663-5330 Email UCSD EI Director Michael Todd (858) 534-5951 Professional Staff Assistant Ellie Vigil (505) 667-2818 Email Administrative Assistant Rebecca Duran (505) 665-8899 Email Journal articles Gabbatto, M., Conte, J, Kosmatka, J. Farrar, C. R., "Reliability-Based Framework for Fatigue Damage Prognosis of Composite Aircraft Structures,"

  16. Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Earthquake Engineering and Structural Dynamics Earthquake Engineering and Structural Dynamics Publications Journal articles are organized by date. Contact Institute Director Charles Farrar (505) 663-5330 Email UCSD EI Director Michael Todd (858) 534-5951 Professional Staff Assistant Ellie Vigil (505) 667-2818 Email Administrative Assistant Rebecca Duran (505) 665-8899 Email Journal articles D. Mascarenas, D. Macknelly, J. Mullins, H. Wiest and G. Park, "Dynamic characterization of satellite

  17. Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Los Alamos Reports Los Alamos Reports Unless identified as SRD (Secret Restricted Data), these reports are available to the public from the National Technical Information Service, Springfield, VA. Contact Institute Director Charles Farrar (505) 663-5330 Email UCSD EI Director Michael Todd (858) 534-5951 Professional Staff Assistant Ellie Vigil (505) 667-2818 Email Administrative Assistant Rebecca Duran (505) 665-8899 Email Los Alamos Reports E. Figueiredo, G. Park, J. Figueiras, C. R. Farrar,

  18. Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Sensors and Sensing Technologies Sensors and Sensing Technologies Publications Journal articles on Sensors and Sensing Technologies Contact Institute Director Charles Farrar (505) 663-5330 Email UCSD EI Director Michael Todd (858) 534-5951 Professional Staff Assistant Ellie Vigil (505) 667-2818 Email Administrative Assistant Rebecca Duran (505) 665-8899 Email Journal Articles Stull, C.J., Taylor, S. G., Wren, J., Mascarenas, D.L., Farrar, C. R., "Real-Time Condition Assessment of the Raptor

  19. Advanced Communication and Control of Distributed Energy Resources at Detroit Edison

    SciTech Connect

    Haukur Asgeirsson; Richard Seguin

    2004-01-31

    The project objective was to create the communication and control system, the process and the economic procedures that will allow owners (e.g., residential, commercial, industrial, manufacturing, etc.) of Distributed Energy Resources (DER) connected in parallel to the electric distribution to have their resources operated in a manner that protects the electric utility distribution network and personnel that may be working on the network. The Distribution Engineering Workstation (DEW) (a power flow and short circuit modeling tool) was modified to calculate the real-time characteristics of the distribution network based on the real-time electric distribution network information and provide DER operating suggestions to the Detroit Edison system operators so that regional electric stability is maintained. Part of the suggestion algorithm takes into account the operational availability of DER’s, which is known by the Energy Aggregator, DTE Energy Technologies. The availability information will be exchanged from DTE Energy Technologies to Detroit Edison. For the calculated suggestions to be used by the Detroit Edison operators, procedures were developed to allow an operator to operate a DER by requesting operation of the DER through DTE Energy Technologies. Prior to issuing control of a DER, the safety of the distribution network and personnel needs to be taken into account. This information will be exchanged from Detroit Edison to DTE Energy Technologies. Once it is safe to control the DER, DTE Energy Technologies will issue the control signal. The real-time monitoring of the DECo system will reflect the DER control. Multi-vendor DER technologies’ representing approximately 4 MW of capacity was monitored and controlled using a web-based communication path. The DER technologies included are a photovoltaic system, energy storage, fuel cells and natural gas/diesel internal combustion engine generators. This report documents Phase I result for the Detroit Edison

  20. US ENC MI Site Consumption

    Energy Information Administration (EIA) (indexed site)

    MI Site Consumption million Btu $0 $500 $1,000 $1,500 $2,000 $2,500 US ENC MI Expenditures dollars ALL ENERGY average per household (excl. transportation) 0 2,000 4,000 6,000 8,000 10,000 12,000 US ENC MI Site Consumption kilowatthours $0 $250 $500 $750 $1,000 $1,250 $1,500 US ENC MI Expenditures dollars ELECTRICITY ONLY average per household * Michigan households use 123 million Btu of energy per home, 38% more than the U.S. average. * High consumption, combined with low costs for heating fuels

  1. Field Demonstration of a 24-kV Superconducting Cable at Detroit Edison

    SciTech Connect

    Kelley, Nathan; Corsaro, Pietro

    2004-12-01

    Customer acceptance of high temperature superconducting (HTS) cable technology requires a substantial field demonstration illustrating both the system's technical capabilities and its suitability for installation and operation within the utility environment. In this project, the world's first underground installation of an HTS cable using existing ductwork, a 120 meter demonstration cable circuit was designed and installed between the 24 kV bus distribution bus and a 120 kV-24 kV transformer at Detroit Edison's Frisbie substation. The system incorporated cables, accessories, a refrigeration system, and control instrumentation. Although the system was never put in operation because of problems with leaks in the cryostat, the project significantly advanced the state-of-the-art in the design and implementation of Warm Dielectric cable systems in substation applications. Lessons learned in this project are already being incorporated in several ongoing demonstration projects.

  2. Evaluation of Fish Passage Conditions for Juvenile Salmonids Using Sensor Fish at Detroit Dam, Oregon

    SciTech Connect

    Duncan, Joanne P.

    2010-01-29

    Fish passage conditions through two spillways at Detroit Dam on the North Santiam River in Oregon were evaluated by Pacific Northwest National Laboratory for the U.S. Army Corps of Engineers (USACE), Portland District, using Sensor Fish devices. The objective of the study was to describe and compare passage exposure conditions through Spillbay 3 and Spillbay 6 at 1.5- and 3.5-ft gate openings, identifying potential fish injury regions of the routes. The study was performed in July 2009, concurrent with HI-Z balloon-tag studies by Normandeau Associates, Inc. Sensor Fish and live fish were deployed at elevations approximately 3 ft above structure at depths determined using a computational fluid dynamics model. Data collected were analyzed to estimate 1) exposure conditions, particularly exposure to severe collision and shear events by passage route sub-regions; 2) differences in passage conditions between passage routes; and 3) relationships to live-fish injury and mortality data estimates.

  3. Coal-water-slurry autoignition in a high-speed Detroit diesel engine

    SciTech Connect

    Schwalb, J.A.; Ryan, T.W. III.; Kakwani, R.M.; Winsor, R.E.

    1994-10-01

    Autoignition of coal-water-slurry (CWS) fuel in a two-stroke engine operating at 1900 RPM has been achieved. A Pump-Line-Nozzle (PLN) injection system, delivering 400mm{sup 3} injection of CWS, was installed in one modified cylinder of a Detroit Diesel Corporation (DDC) 8V-149TI engine, while the other seven cylinders remained configured for diesel fuel. Coal Combustion was sustained by maintaining high gas and surface temperatures with a combination of hot residual gases, warm inlet air admission, ceramic insulated components and increased compression ratio. The coal-fueled cylinder generated 85kW indicated power (80 percent of rated power), and lower NO{sub x} levels with a combustion efficiency of 99.2 percent. 6 refs., 15 figs., 4 tabs.

  4. US ENC MI Site Consumption

    Annual Energy Outlook

    ... Yes Yes No No 0% 20% 40% 60% 80% 100% US MI No Car CAR IS PARKED WITHIN 20 FT OF ELECTRICAL OUTLET More highlights from RECS on housing characteristics and energy-related ...

  5. Thermoelectric Conversion of Wate Heat to Electricity in an IC...

    Energy.gov [DOE] (indexed site)

    and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. deer10schock.pdf (2.44 MB) More Documents & Publications Thermoelectric Conversion of Waste

  6. Real-time sub-<mi>>ngstrom...

    Office of Scientific and Technical Information (OSTI)

    Real-time sub-<mi>>ngstrom imaging of reversible and irreversible conformations in rhodium catalysts and graphene Kisielowski, Christian; Wang,...

  7. The Detroit Diesel DELTA Engine for Light Trucks and SUVs - Year 2000 Update

    SciTech Connect

    Nabil S. Hakim; Charles E. Freese; Stanley P. Miller

    2000-06-19

    Detroit Diesel Corporation (DDC) is developing the DELTA 4.0L V6 engine, specifically for the North American light truck market. This market poses unique requirements for a diesel engine, necessitating a clean sheet engine design. DELTA was developed from a clean sheet of paper, with the first engine firing just 228 days later. The process began with a Quality Function Deployment (QFD) analysis, which prioritized the development criteria. The development process integrated a co-located, fully cross-functional team. Suppliers were fully integrated and maintained on-site representation. The first demonstration vehicle moved under its own power 12 weeks after the first engine fired. It was demonstrated to the automotive press 18 days later. DELTA has repeatedly demonstrated its ability to disprove historical North American diesel perceptions and compete directly with gasoline engines. This paper outlines the Generation 0.0 development process and briefly defines the engine. A brief indication of the Generation 0.5 development status is given.

  8. Mi GmbH | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Mi GmbH Jump to: navigation, search Name: Mi GmbH Place: Switzerland Zip: CH-6340 Sector: Solar Product: Baar-based manufacturer and distributor of fruit juices. The firm is also...

  9. miRNAs in brain development

    SciTech Connect

    Petri, Rebecca; Malmevik, Josephine; Fasching, Liana; Åkerblom, Malin; Jakobsson, Johan

    2014-02-01

    MicroRNAs (miRNAs) are small, non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. In the brain, a large number of miRNAs are expressed and there is a growing body of evidence demonstrating that miRNAs are essential for brain development and neuronal function. Conditional knockout studies of the core components in the miRNA biogenesis pathway, such as Dicer and DGCR8, have demonstrated a crucial role for miRNAs during the development of the central nervous system. Furthermore, mice deleted for specific miRNAs and miRNA-clusters demonstrate diverse functional roles for different miRNAs during the development of different brain structures. miRNAs have been proposed to regulate cellular functions such as differentiation, proliferation and fate-determination of neural progenitors. In this review we summarise the findings from recent studies that highlight the importance of miRNAs in brain development with a focus on the mouse model. We also discuss the technical limitations of current miRNA studies that still limit our understanding of this family of non-coding RNAs and propose the use of novel and refined technologies that are needed in order to fully determine the impact of specific miRNAs in brain development. - Highlights: • miRNAs are essential for brain development and neuronal function. • KO of Dicer is embryonically lethal. • Conditional Dicer KO results in defective proliferation or increased apoptosis. • KO of individual miRNAs or miRNA families is necessary to determine function.

  10. Hydroacoustic Evaluation of Juvenile Salmonid Passage and Distribution at Detroit Dam, 2011

    SciTech Connect

    Khan, Fenton; Royer, Ida M.; Johnson, Gary E.; Ham, Kenneth D.

    2012-11-15

    Pacific Northwest National Laboratory evaluated juvenile salmonid passage and distribution at Detroit Dam (DET) on the North Santiam River, Oregon for the U.S. Army Corps of Engineers (USACE) to provide data to support decisions on long-term measures to enhance downstream passage at DET and others dams in USACE’s Willamette Valley Project. This study was conducted in response to regulatory requirements necessitated by the listing of Upper Willamette River Spring Chinook salmon (Oncorhynchus tshawytscha) and Upper Willamette River steelhead (O. mykiss) as threatened under the Endangered Species Act. The goal of the study was to provide information of juvenile salmonid passage and distribution at DET from February 2011 through February 2012. The results of the hydroacoustic study provide new and, in some cases, first-ever data on passage estimates, run timing, distributions, and relationships between fish passage and environmental variables at the dam. This information will inform management decisions on the design and development of surface passage and collection devices to help restore Chinook salmon populations in the North Santiam River watershed above DET. During the entire study period, an estimated total of 182,526 smolt-size fish (±4,660 fish, 95% CI) passed through turbine penstock intakes. Run timing peaked in winter and early spring months. Passage rates were highest during late fall, winter and early spring months and low during summer. Horizontal distribution for hours when both turbine units were operated simultaneously indicated Unit 2 passed almost twice as much fish as Unit 1. Diel distribution for smolt-size fish during the study period was fairly uniform, indicating fish were passing the turbines at all times of the day. A total of 5,083 smolt-size fish (± 312 fish, 95% CI) were estimated passed via the spillway when it was open between June 23 and September 27, 2011. Daily passage was low at the spillway during the June-August period, and

  11. DOE - Office of Legacy Management -- Adrian - MI 01

    Office of Legacy Management (LM)

    Adrian - MI 01 FUSRAP Considered Sites Adrian, MI Alternate Name(s): Bridgeport Brass Co. Special Metals Extrusion Plant Bridgeport Brass Company General Motors General Motors Company, Adrian MI.01-1 Location: 1450 East Beecher Street, Adrian, Michigan MI.01-3 Historical Operations: Performed uranium extrusion research and development and metal fabrication work for the AEC using uranium, thorium, and plutonium. MI.01-2 Eligibility Determination: Eligible MI.01-1 Radiological Survey(s):

  12. DOE - Office of Legacy Management -- Oliver Corp - MI 11

    Office of Legacy Management (LM)

    OLIVER CORP. (MI.11 ) Eliminated from further consideration under FUSRAP - Referred to NRC Designated Name: Not Designated Alternate Name: Behnke Warehousing Incorporated MI.11-1...

  13. Gratiot | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Wind energy Facility Type Commercial Scale Wind Facility Status In Service Owner Detroit Edison Developer Invenergy Energy Purchaser Detroit Edison Location Breckenridge MI...

  14. The NuMI neutrino beam

    DOE PAGES [OSTI]

    Adamson, P.; Anderson, K.; Andrews, M.; Andrews, R.; Anghel, I.; Augustine, D.; Aurisano, A.; Avvakumov, S.; Ayres, D. S.; Baller, B.; et al

    2015-10-20

    Our paper describes the hardware and operations of the Neutrinos at the Main Injector (NuMI) beam at Fermilab. It elaborates on the design considerations for the beam as a whole and for individual elements. The most important part of our design details pertaining to individual components is described. Beam monitoring systems and procedures, including the tuning and alignment of the beam and NuMI long-term performance, are also discussed.

  15. The NuMI Neutrino Beam

    SciTech Connect

    Adamson, P.; Anderson, K.; Andrews, M.; Andrews, R.; Anghel, I.; Augustine, D.; Aurisano, A.; Avvakumov, S.; Ayres, D. S.; Baller, B.; Barish, B.; Barr, G.; Barrett, W. L.; Berstein, R. H.; Biggs, J.; Bishai, M.; Blake, A.; Bocean, V.; Bock, G. J.; Boehnlein, D. J.; Bogert, D.; Bourkland, K.; Cao, S. V.; Castromonte, C. M.; Childress, S.; Choudhary, B. C.; Coelho, J. A.B.; Cobb, J. H.; Corwin, L.; Crane, D.; Cravens, J. P.; Cronin-Hennessy, D.; Ducar, R. J.; De Jong, J. K.; Devan, A. V.; Devenish, N. E.; Diwan, M. V.; Erwin, A. R.; Escobar, C. O.; Evans, J. J.; Falk, E.; Feldman, G. J.; Fields, T. H.; Ford, R.; Frohne, M. V.; Gallahger, H. R.; Garkusha, V.; Gomes, R. A.; Goodman, M. C.; Gouffon, P.; Graf, N.; Gran, R.; Grossman, N.; Grzelak, K.; Habig, A.; Hahn, S. R.; Harding, D.; Harris, D.; Harris, P. G.; Hartnell, J.; Hatcher, R.; Hays, S.; Heller, K.; Holin, A.; Huang, J.; Hylen, J.; Ibrahim, A.; Indurthy, D.; Irwin, G. M.; Isvan, Z.; Jaffe, D. E.; James, C.; Jensen, D.; Johnstone, J.; Kafka, T.; Kasahara, S. M.S.; Koizumi, G.; Kopp, S.; Kordosky, M.; Kreymer, A.; Lang, K.; Laughton, C.; Lefeuvre, G.; Ling, J.; Litchfield, P. J.; Loiacono, L.; Lucas, P.; Mann, W. A.; Marchionni, A.; Marshak, M. L.; Mayer, N.; McGivern, C.; Medeiros, M. M.; Mehdiyev, R.; Meier, J. R.; Messier, M. D.; Michael, D. G.; Milburn, R. H.; Miller, J. L.; Miller, W. H.; Mishra, S. R.; Sher, S. Moed; Moore, C. D.; Morfin, J.; Mualem, L.; Mufson, S.; Murgia, S.; Murtagh, M.; Musser, J.; Naples, D.; Nelson, J. K.; Newman, H. B.; Nichol, R. J.; Nowak, J. A.; O'connor, J.; Oliver, W. P.; Olsen, M.; Orchanian, M.; Osprey, S.; Pahlka, R. B.; Paley, J.; Para, A.; Patterson, R. B.; Patzak, T.; Pavlovic, Z.; Pawloski, G.; Perch, A.; Peterson, E. A.; Petyt, D. A.; Pfutzner, M. M.; Phan-Budd, S.; Plunkett, R. K.; Poonthottathil, N.; Prieto, P.; Pushka, D.; Qiu, X.; Radovic, A.; Rameika, R. A.; Ratchford, J.; Rebel, B.; Reilly, R.; Rosenfeld, C.; Rubin, H. A.; Ruddick, K.; Sanchez, M. C.; Saoulidou, N.; Sauer, L.; Schneps, J.; Schoo, D.; Schreckenberger, A.; Schreiner, P.; Shanahan, P.; Sharma, R.; Smart, W.; Smith, C.; Sousa, A.; Stefanik, A.; Tagg, N.; Talaga, R. L.; Tassotto, G.; Thomas, J.; Thompson, J.; Thomson, M. A.; Tian, X.; Timmons, A.; Tinsley, D.; Tognini, S. C.; Toner, R.; Torretta, D.; Trostin, I.; Tzanakos, G.; Urheim, J.; Vahle, P.; Vaziri, K.; Villegas, E.; Viren, B.; Vogel, G.; Webber, R. C.; Weber, A.; Webb, R. C.; Wehmann, A.; White, C.; Whitehead, L.; Whitehead, L. H.; Wojcicki, S. G.; Wong-Squires, M. L.; Yang, T.; Yumiceva, F. X.; Zarucheisky, V.; Zwaska, R.

    2015-10-20

    Our paper describes the hardware and operations of the Neutrinos at the Main Injector (NuMI) beam at Fermilab. It elaborates on the design considerations for the beam as a whole and for individual elements. The most important part of our design details pertaining to individual components is described. Beam monitoring systems and procedures, including the tuning and alignment of the beam and NuMI long-term performance, are also discussed.

  16. MINERvA Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    MINERvA Publications "Measurements of the Inclusive Neutrino and Antineutrino Charged Current Cross Sections in MINERvA Using the Low-ν Flux Method" "Neutrino Flux Predictions for the NuMI Beam" accepted for publication in Phys. Rev. D "First evidence of coherent K+ meson production in neutrino-nucleus scattering" Phys. Rev. Lett. 117, 061802 (2016) "Measurement of K+ production in charged-current νμ interactions" Phys. Rev. D 94, 012002 (2016)

  17. ARM - Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    govPublications Publications Journal Articles Conference Documents Program Documents & Technical Reports Publications Database Public Information Materials Image Library Videos ...

  18. Post Mortem of 120k mi Light-Duty Urea SCR and DPF System

    Energy.gov [DOE]

    Presentation given at the 2007 Diesel Engine-Efficiency & Emissions Research Conference (DEER 2007). 13-16 August, 2007, Detroit, Michigan. Sponsored by the U.S. Department of Energy's (DOE) Office of FreedomCAR and Vehicle Technologies (OFCVT).

  19. Port Huron, MI Liquefied Natural Gas Exports to Canada (Million...

    Energy Information Administration (EIA) (indexed site)

    Huron, MI Liquefied Natural Gas Exports to Canada (Million Cubic Feet) Port Huron, MI Liquefied Natural Gas Exports to Canada (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul ...

  20. DOE - Office of Legacy Management -- Naval Ordnance Plant - MI...

    Office of Legacy Management (LM)

    Eliminated from further consideration under FUSRAP - Referred to DoD for action Designated ... MI.0-03-1 Site Disposition: Eliminated - No Authority - Referred to DoD MI.0-03-1 ...

  1. miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor

    SciTech Connect

    Park, Jong-Kook; Henry, Jon C.; Jiang, Jinmai; Esau, Christine; Gusev, Yuriy; Lerner, Megan R.; Postier, Russell G.; Brackett, Daniel J.; Schmittgen, Thomas D.

    2011-03-25

    Research highlights: {yields} The expression of miR-132 and miR-212 are significantly increased in pancreatic cancer. {yields} miR-132 and miR-212 target the tumor suppressor pRb, resulting in enhanced proliferation. {yields} miR-132 and miR-212 expression is increased by a {beta}2 adrenergic receptor agonist, suggesting a novel mechanism for pancreatic cancer progression. -- Abstract: Numerous microRNAs (miRNAs) are reported as differentially expressed in cancer, however the consequence of miRNA deregulation in cancer is unknown for many miRNAs. We report that two miRNAs located on chromosome 17p13, miR-132 and miR-212, are over-expressed in pancreatic adenocarcinoma (PDAC) tissues. Both miRNAs are predicted to target the retinoblastoma tumor suppressor, Rb1. Validation of this interaction was confirmed by luciferase reporter assay and western blot in a pancreatic cancer cell line transfected with pre-miR-212 and pre-miR-132 oligos. Cell proliferation was enhanced in Panc-1 cells transfected with pre-miR-132/-212 oligos. Conversely, antisense oligos to miR-132/-212 reduced cell proliferation and caused a G{sub 2}/M cell cycle arrest. The mRNA of a number of E2F transcriptional targets were increased in cells over expressing miR-132/-212. Exposing Panc-1 cells to the {beta}2 adrenergic receptor agonist, terbutaline, increased the miR-132 and miR-212 expression by 2- to 4-fold. We report that over-expression of miR-132 and miR-212 result in reduced pRb protein in pancreatic cancer cells and that the increase in cell proliferation from over-expression of these miRNAs is likely due to increased expression of several E2F target genes. The {beta}2 adrenergic pathway may play an important role in this novel mechanism.

  2. “Nodal Gap” induced by the incommensurate diagonal spin density modulation in underdoped high- <mi>Tmi>c> superconductors

    SciTech Connect

    Zhou, Tao; Gao, Yi; Zhu, Jian -Xin

    2015-03-07

    Recently it was revealed that the whole Fermi surface is fully gapped for several families of underdoped cuprates. The existence of the finite energy gap along the <mi>d>-wave nodal lines (nodal gap) contrasts the common understanding of the <mi>d>-wave pairing symmetry, which challenges the present theories for the high-<mi>Tmi><mi>c>superconductors. Here we propose that the incommensurate diagonal spin-density-wave order can account for the above experimental observation. The Fermi surface and the local density of states are also studied. Our results are in good agreement with many important experiments in high-<mi>Tmi><mi>c>superconductors.

  3. Characterization of function and regulation of miR-24-1 and miR-31

    SciTech Connect

    Sun Fenyong; Wang Jiayi; Pan Qiuhui; Yu Yongchun; Zhang Yue; Wan Yang; Wang Ju; Li Xiaoyan; Hong An

    2009-03-13

    To date, numerous microRNAs (miRNAs) have been discovered. However, the function of these miRNAs is largely unknown. While our knowledge of miRNA post-transcriptional processing has greatly expanded in recent years, we have a limited understanding of the regulation and transcription of miRNA genes. In this study, we characterized two BMP-2 upregulated miRNAs, miR-24-1 and miR-31, in mesenchymal stem cells and showed their opposing function in controlling cellular proliferation, and adipogenesis. Furthermore, we are the first to identify and characterize mouse intronic miR-23b{approx}27b{approx}24-1 and intergenic miR-31 genes. Moreover, we found that pri-miR-23b, pri-miR-27b, and pri-miR-24-1 are transcribed independently and their expression profiles are unique when cells are treated with BMP-2, even though they are located closely together.

  4. Characterization of Fish Passage Conditions through a Francis Turbine, Spillway, and Regulating Outlet at Detroit Dam, Oregon, Using Sensor Fish, 2009

    SciTech Connect

    Duncan, Joanne P.; Carlson, Thomas J.

    2011-05-06

    Fish passage conditions through two spillways, a Francis turbine, and a regulating outlet (RO) at Detroit Dam on the North Santiam River in Oregon were evaluated by Pacific Northwest National Laboratory for the U.S. Army Corps of Engineers (USACE), Portland District, using Sensor Fish devices. The objective of the study was to describe and compare passage exposure conditions, identifying potential fish injury regions within the routes. The study was performed in July, October, and December 2009 concurrent with HI-Z balloon-tag studies by Normandeau Associates, Inc. Sensor Fish data were analyzed to estimate 1) exposure conditions, particularly exposure to severe strike, collision, and shear events by passage route sub-regions; 2) differences in passage conditions between passage routes; and 3) relationships to live-fish injury and mortality data estimates. Comparison of the three passage routes evaluated at Detroit Dam indicates that the RO passage route through the 5-ft gate opening was relatively the safest route for fish passage under the operating conditions tested; turbine passage was the most deleterious. These observations were supported also by the survival and malady estimates obtained from live-fish testing. Injury rates were highest for turbine and spillway passage. However, none of the passage routes tested is safe for juvenile salmonid passage.

  5. Detroit Commuter Hydrogen Project

    Office of Energy Efficiency and Renewable Energy (EERE)

    2009 DOE Hydrogen Program and Vehicle Technologies Program Annual Merit Review and Peer Evaluation Meeting, May 18-22, 2009 -- Washington D.C.

  6. Magnetocrystalline anisotropy in <mi>UMn>2<mi>Ge>2 and related Mn-based actinide ferromagnets

    SciTech Connect

    Parker, David S.; Ghimire, Nirmal; Singleton, John; Thompson, J. D.; Bauer, Eric D.; Baumbach, Ryan; Mandrus, David; Li, Ling; Singh, David J.

    2015-05-04

    We present magnetization isotherms in pulsed magnetic fields up to 62 Tesla, supported by first principles calculations, demonstrating a huge uniaxial magnetocrystalline anisotropy energy - approximately 20 MJ/m3 - in <mi>UMn>2<mi>Ge>2. This large anisotropy results from the extremely strong spin-orbit coupling affecting the uranium 5 f electrons, which in the calculations exhibit a substantial orbital moment exceeding 2 μB. Finally, we also find from theoretical calculations that a number of isostructural Mn-actinide compounds are expected to have similarly large anisotropy.

  7. DOE - Office of Legacy Management -- Star Cutter Corp - MI 15

    Office of Legacy Management (LM)

    Eliminated - Potential for contamination considered remote based on limited scope and quantity of materials handled MI.15-2 Radioactive Materials Handled: Yes Primary ...

  8. LBNL: Architecture 2030 District Program and Small Commercial...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Silicon Valley City of San Jose - San Jose, CA - Arizona State University - Phoenix, AZ - Emerging 2030 Districts - Ann Arbor, MI; Detroit, MI; San Antonio, TX; Ithaca, ...

  9. Tax Credits, Rebates & Savings | Department of Energy

    Energy.gov [DOE] (indexed site)

    Detroit Public Lighting Department- Commercial and Industrial Energy Wise Program The Detroit Public Lighting Department (PLD) offers commercial and industrial customers rebates...

  10. Tax Credits, Rebates & Savings | Department of Energy

    Energy.gov [DOE] (indexed site)

    Detroit Public Lighting Department- Commercial and Industrial Energy Wise Program The Detroit Public Lighting Department (PLD) offers commercial and industrial customers...

  11. Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells

    SciTech Connect

    Vrba, Lukas; Jensen, Taylor J.; Garbe, James C.; Heimark, Ronald L.; Cress, Anne E.; Dickinson, Sally; Stampfer, Martha R.; Futscher, Bernard W.

    2009-12-23

    BACKGROUND: The microRNA-200 family participates in the maintenance of an epithelial phenotype and loss of its expression can result in epithelial to mesenchymal transition (EMT). Furthermore, the loss of expression of miR-200 family members is linked to an aggressive cancer phenotype. Regulation of the miR-200 family expression in normal and cancer cells is not fully understood. METHODOLOGY/ PRINCIPAL FINDINGS: Epigenetic mechanisms participate in the control of miR-200c and miR-141 expression in both normal and cancer cells. A CpG island near the predicted mir-200c/mir-141 transcription start site shows a striking correlation between miR-200c and miR-141 expression and DNA methylation in both normal and cancer cells, as determined by MassARRAY technology. The CpG island is unmethylated in human miR-200/miR-141 expressing epithelial cells and in miR-200c/miR-141 positive tumor cells. The CpG island is heavily methylated in human miR-200c/miR-141 negative fibroblasts and miR-200c/miR-141 negative tumor cells. Mouse cells show a similar inverse correlation between DNA methylation and miR-200c expression. Enrichment of permissive histone modifications, H3 acetylation and H3K4 trimethylation, is seen in normal miR-200c/miR-141-positive epithelial cells, as determined by chromatin immunoprecipitation coupled to real-time PCR. In contrast, repressive H3K9 dimethylation marks are present in normal miR-200c/miR-141-negative fibroblasts and miR-200c/miR-141 negative cancer cells and the permissive histone modifications are absent. The epigenetic modifier drug, 5-aza-2'-deoxycytidine, reactivates miR-200c/miR-141 expression showing that epigenetic mechanisms play a functional role in their transcriptional control. CONCLUSIONS/ SIGNIFICANCE: We report that DNA methylation plays a role in the normal cell type-specific expression of miR-200c and miR-141 and this role appears evolutionarily conserved, since similar results were obtained in mouse. Aberrant DNA methylation of the

  12. miR-92a family and their target genes in tumorigenesis and metastasis

    SciTech Connect

    Li, Molin; Guan, Xingfang; Sun, Yuqiang; Mi, Jun; Shu, Xiaohong; Liu, Fang; Li, Chuangang

    2014-04-15

    The miR-92a family, including miR-25, miR-92a-1, miR-92a-2 and miR-363, arises from three different paralog clusters miR-17-92, miR-106a-363, and miR-106b-25 that are highly conservative in the process of evolution, and it was thought as a group of microRNAs (miRNAs) correlated with endothelial cells. Aberrant expression of miR-92a family was detected in multiple cancers, and the disturbance of miR-92a family was related with tumorigenesis and tumor development. In this review, the progress on the relationship between miR-92a family and their target genes and malignant tumors will be summarized. - Highlights: • Aberrant expression of miR-92a, miR-25 and miR-363 can be observed in many kinds of malignant tumors. • The expression of miR-92a family is regulated by LOH, epigenetic alteration, transcriptional factors such as SP1, MYC, E2F, wild-type p53 etc. • Roles of miR-92a family in tumorigenesis and development: promoting cell proliferation, invasion and metastasis, inhibiting cell apoptosis.

  13. Publications | NREL

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications The NREL Publications Database contains bibliographic information about publications developed or written by NREL staff and subcontractors. Search the database for publications from 1977 to the present on subjects related to renewable energy and energy-efficient technologies. Many publications are available electronically as Adobe Acrobat PDFs. The database includes technical reports, journal articles, conference papers, patents, presentations, books, fact sheets, and brochures.

  14. NREL: Transportation Research - Vehicle Thermal Management Publication...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... Fuel Use from Cabin Ventilation, Solar-Reflective Paint, and New Solar-Reflective Glazing. ... Kogler, R. Presented at the 2007 SAE World Congress April 16-19, 2007, Detroit, Michigan. ...

  15. Public Meetings

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Public Meetings Individual Permit: Public Meetings Subscribe to receive notifications for semiannual Individual Permit for Storm Water public meetings. Contact Environmental Communication & Public Involvement P.O. Box 1663 MS M996 Los Alamos, NM 87545 (505) 667-0216 Email Public meeting notifications LANL will email a draft agenda at least one week before the meeting and will consider suggestions from the public for changes or additions to the agenda. Upcoming Meetings 2016 October 18, 2016

  16. Port Huron, MI Natural Gas Pipeline Imports From Canada (Million...

    Energy Information Administration (EIA) (indexed site)

    Million Cubic Feet) Port Huron, MI Natural Gas Pipeline Imports From Canada (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2016 262 - No Data Reported; ...

  17. Related Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Skip navigation links Financial Information Financial Public Processes Asset Management Cost Verification Process Rate Cases BP-18 Rate Case Related Publications Meetings...

  18. CNEEC - Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    CNEEC archival journal publications CNEEC maintains two lists of publications, one devoted to research solely supported by funding from the CNEEC EFRC and another containing...

  19. miR-107 and miR-25 simultaneously target LATS2 and regulate proliferation and invasion of gastric adenocarcinoma (GAC) cells

    SciTech Connect

    Zhang, Mingjun; Wang, Xiaolei; Li, Wanhu; Cui, Yongchun

    2015-05-08

    Although a series of oncogenes and tumor suppressors were identified in the pathological development of gastric adenocarcinoma (GAC), the underlying molecule mechanism were still not fully understood. The current study explored the expression profile of miR-107 and miR-25 in GAC patients and their downstream regulative network. qRT-PCR analysis was performed to quantify the expression of these two miRNAs in serum samples from both patients and healthy controls. Dual luciferase assay was conducted to verify their putative bindings with LATS2. MTT assay, cell cycle assay and transwell assay were performed to explore how miR-107 and miR-25 regulate proliferation and invasion of gastric cancer cells. Findings of this study demonstrated that total miR-107 or miR-25 expression might be overexpressed in gastric cancer patients and they can simultaneously and synchronically regulate LATS2 expression, thereby affecting gastric cancer cell growth and invasion. Therefore, the miR-25/miR-107-LATS2 axis might play an important role in proliferation and invasion of the gastric cancer cells. - Highlights: • Total miR-107 and miR-25 expression is significantly increased in GAC patients. • Both miR-107 and miR-25 can promote proliferation and invasion of GAC cells. • Both miR-107 and miR-25 can target LATS2 and regulate its expression. • miR-107 and miR-25 regulate proliferation and invasion of GAC cells though LATS2.

  20. ARM Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications Thu, 01 Jan 1970 00:00:00 +0000 http://www.arm.gov en Publication Notice: 2 New References Available Thu, 01 Jan 1970 00:00:00 +0000 Publications http://www.arm.gov/publications?date=20161118#20161118 &#60;strong&#62;Lead Author(s)&#60;/strong&#62; Schmid B | Cook DR [...] Publication Notice: 3 New References Available Thu, 01 Jan 1970 00:00:00 +0000 Publications http://www.arm.gov/publications?date=20161116#20161116 &#60;strong&#62;Lead

  1. miR-17 inhibitor suppressed osteosarcoma tumor growth and metastasis via increasing PTEN expression

    SciTech Connect

    Gao, Yong; Luo, Ling-hui; Li, Shuai; Yang, Cao

    2014-02-07

    Highlights: • miR-17 was increased in OS tissues and cell lines. • Inhibition of miR-17 suppressed OS cell proliferation. • Inhibition of miR-17 suppressed OS cell migration and invasion. • PTEN was a target of miR-17. • miR-17 was negatively correlated with PTEN in OS tissues. - Abstract: MicroRNAs (miRNAs) play essential roles in cancer development and progression. Here, we investigated the role of miR-17 in the progression and metastasis of osteosarcoma (OS). miR-17 was frequently increased in OS tissues and cell lines. Inhibition of miR-17 in OS cell lines substantially suppressed cell proliferation, migration, and invasion. Phosphatase and tensin homolog (PTEN) was identified as a target of miR-17, and ectopic expression of miR-17 inhibited PTEN by direct binding to its 3′-untranslated region (3′-UTR). Expression of miR-17 was negatively correlated with PTEN in OS tissues. Together, these findings indicate that miR-17 acts as an oncogenic miRNA and may contribute to the progression and metastasis of OS, suggesting miR-17 as a potential novel diagnostic and therapeutic target of OS.

  2. WINDExchange: Publications

    WindExchange

    Information Resources Printable Version Bookmark and Share Publications Webinars Podcasts Economic Development Studies Wind Turbine Ordinances Awards Publications This page lists all of the publications referenced on the WINDExchange initiative's website. Search the WINDExchange Database Choose a Subject Category All Agricultural Public Power Schools Small Wind Economic Development Policy Start Search Clear Search Filtered by: Publication Date State Program Area Title 10/19/2016 Grounds for

  3. Tax Credits, Rebates & Savings | Department of Energy

    Energy.gov [DOE] (indexed site)

    Detroit Green Fund Loan The Economic Development Corporation (EDC) of the City of Detroit is offering financial assistance to commercial, institutional and public buildings...

  4. ARM - Public Information Materials

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    govPublicationsPublic Information Materials Publications Journal Articles Conference Documents Program Documents Technical Reports Publications Database Public Information...

  5. MiR-218 Mediates tumorigenesis and metastasis: Perspectives and implications

    SciTech Connect

    Lu, Ying-fei; Zhang, Li; Waye, Mary Miu Yee; Fu, Wei-ming; Zhang, Jin-fang

    2015-05-15

    MicroRNAs (miRNAs) are a class of small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. As a highly conserved miRNA across a variety of species, microRNA-218 (miR-218) was found to play pivotal roles in tumorigenesis and progression. A group of evidence has demonstrated that miR-218 acts as a tumor suppressor by targeting many oncogenes related to proliferation, apoptosis and invasion. In this review, we provide a complex overview of miR-218, including its regulatory mechanisms, known functions in cancer and future challenges as a potential therapeutic target in human cancers. - Highlights: • miR-218 is frequently down regulated in multiple cancers. • miR-218 plays pivotal roles in carcinogenesis. • miR-218 mediates proliferation, apoptosis, metastasis, invasion, etc. • miR-218 mediates tumorigenesis and metastasis via multiple pathways.

  6. Energy Deputy Secretary Poneman Tours Minority-Owned Small Business in

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Detroit | Department of Energy Tours Minority-Owned Small Business in Detroit Energy Deputy Secretary Poneman Tours Minority-Owned Small Business in Detroit May 22, 2012 - 10:37am Addthis Deputy Secretary of Energy Daniel Poneman meets with owners and workers at Diversified Chemical Technologies, a small business in Detroit, MI. | Energy Department photo Deputy Secretary of Energy Daniel Poneman meets with owners and workers at Diversified Chemical Technologies, a small business in Detroit,

  7. Public Activities

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    passes. Roadways that are off limits to visiting members of the public will be posted with signs, and motorists will be given site maps to guide them to the public areas....

  8. Public Activities

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Bird Watching Effective January 24, 2005 There are several great bird watching spots in the public areas on Fermilab's site. Driving is restricted to the roads within the public...

  9. Publication Policy

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    publication policy Publication Policy Publication of work performed at JLF JLF encourages dissemination of results of experiments performed at the Facility. Vehicles for the publication may include: Journal articles Conference proceedings articles Books or book chapters Technical reports Dissertations Published patents Published abstracts Invited or contributed talks Popular articles Press reports The decision whether to publish and in what form(s) is the responsibility of the Principal

  10. NuMI Low Energy Flux Prediction Release

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    NuMI Low Energy Flux Prediction Release Neutrino Flux Predictions for the NuMI Beam hep-ex/1607.00704 Data Ancillary data files for this result are available on arXiv at http://arxiv.org/src/1607.00704/anc Among the available data files are: pdf file describing format of all the available files root file of all the available fluxes python code to read and process MINERvA's flux predictions Text Files of the flux, uncertainties, and covariance matrix, with units of neutrinos/m^2/POT, in 0.5 GeV

  11. miRNA-205 affects infiltration and metastasis of breast cancer

    SciTech Connect

    Wang, Zhouquan; Department of Tumor, SenGong Hospital of Shaanxi, Xian 710300 ; Liao, Hehe; Deng, Zhiping; Yang, Po; Du, Ning; Zhanng, Yunfeng; Ren, Hong

    2013-11-08

    Highlights: We detected expression of miR-205 in breast cancer cell lines and tissue samples. We suggest miR-205 is downregulated in human breast cancer tissues and MCF7 cells. We suggest the lower expression of miR-205 play a role in breast cancer onset. These data suggest that miR-205 directly targets HER3 in human breast cancer. -- Abstract: Background: An increasing number of studies have shown that miRNAs are commonly deregulated in human malignancies, but little is known about the function of miRNA-205 (miR-205) in human breast cancer. The present study investigated the influence of miR-205 on breast cancer malignancy. Methods: The expression level of miR-205 in the MCF7 breast cancer cell line was determined by quantitative (q)RT-PCR. We then analyzed the expression of miR-205 in breast cancer and paired non-tumor tissues. Finally, the roles of miR-205 in regulating tumor proliferation, apoptosis, migration, and target gene expression were studied by MTT assay, flow cytometry, qRT-PCR, Western blotting and luciferase assay. Results: miR-205 was downregulated in breast cancer cells or tissues compared with normal breast cell lines or non-tumor tissues. Overexpression of miR-205 reduced the growth and colony-formation capacity of MCF7 cells by inducing apoptosis. Overexpression of miR-205 inhibited MCF7 cell migration and invasiveness. By bioinformation analysis, miR-205 was predicted to bind to the 3? untranslated regions of human epidermal growth factor receptor (HER)3 mRNA, and upregulation of miR-205 reduced HER3 protein expression. Conclusion: miR-205 is a tumor suppressor in human breast cancer by post-transcriptional inhibition of HER3 expression.

  12. Ground Motion Studies at NuMI

    SciTech Connect

    Mayda M. Velasco; Michal Szleper

    2012-02-20

    Ground motion can cause significant deterioration in the luminosity of a linear collider. Vibration of numerous focusing magnets causes continuous misalignments, which makes the beam emittance grow. For this reason, understanding the seismic vibration of all potential LC sites is essential and related efforts in many sites are ongoing. In this document we summarize the results from the studies specific to Fermilab grounds as requested by the LC project leader at FNAL, Shekhar Mishra in FY04-FY06. The Northwestern group focused on how the ground motion effects vary with depth. Knowledge of depth dependence of the seismic activity is needed in order to decide how deep the LC tunnel should be at sites like Fermilab. The measurements were made in the NuMI tunnel, see Figure 1. We take advantage of the fact that from the beginning to the end of the tunnel there is a height difference of about 350 ft and that there are about five different types of dolomite layers. The support received allowed to pay for three months of salary of Michal Szleper. During this period he worked a 100% of his time in this project. That include one week of preparation: 2.5 months of data taking and data analysis during the full period of the project in order to guarantee that we were recording high quality data. We extended our previous work and made more systematic measurements, which included detailed studies on stability of the vibration amplitudes at different depths over long periods of time. As a consequence, a better control and more efficient averaging out of the daytime variation effects were possible, and a better study of other time dependences before the actual depth dependence was obtained. Those initial measurements were made at the surface and are summarized in Figure 2. All measurements are made with equipment that we already had (two broadband seismometers KS200 from GEOTECH and DL-24 portable data recorder). The offline data analysis took advantage of the full Fourier spectra

  13. DOE - Office of Legacy Management -- Mitts-Merrill Co - MI 14

    Office of Legacy Management (LM)

    1993 MI.14-2 Site Operations: Reduced thorium metal chunks into particle sized pieces ... Primary Radioactive Materials Handled: Thorium MI.14-1 Radiological Survey(s): Yes - ...

  14. DOE - Office of Legacy Management -- Mitts-Merrel Co - MI 14

    Office of Legacy Management (LM)

    1993 MI.14-2 Site Operations: Reduced thorium metal chunks into particle sized pieces ... Primary Radioactive Materials Handled: Thorium MI.14-1 Radiological Survey(s): Yes - ...

  15. ARM - Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    HomeroomPublications Outreach Home Room News Publications Traditional Knowledge Kiosks Barrow, Alaska Tropical Western Pacific Site Tours Contacts Students Study Hall About ARM Global Warming FAQ Just for Fun Meet our Friends Cool Sites Teachers Teachers' Toolbox Lesson Plans Publications Climate Education Update Newsletter Would you like to receive our bi-annual newsletter directly to your inbox? Send your contact information to pubs@arm.gov to be added to our distribution. January 2013 An

  16. PNNL: Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Search Welcome to the Pacific Northwest National Laboratory publications page. You can use this page to find citations to materials published since 1998 by PNNL staff or by external researchers using PNNL facilities. The latter are denoted by a logo preceding the citation. Full text copies of many PNNL formal reports are available from this page either as PDF or HTML files. Search Tips Help Select Search Criteria Publication Types All Publications Journal Article Formal Report Conference Paper

  17. Publications | NISAC

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications Publications Thumbnail image of the cover for the Combined Heat and Power (CHP): A Decade of Progress, A Vision for the Future, October 2009 Numerous publications are available to help educate end users, product developers, project managers, and policymakers on the many potential benefits of distributed generation and combined heat and power (CHP) and the barriers to widespread deployment of these technologies. Among these resources are market analyses, databases, fact sheets,

  18. MiR-125a TNF receptor-associated factor 6 to inhibit osteoclastogenesis

    SciTech Connect

    Guo, Li-Juan; Liao, Lan; Yang, Li; Li, Yu; Jiang, Tie-Jian

    2014-02-15

    MicroRNAs (miRNAs) play important roles in osteoclastogenesis and bone resorption. In the present study, we found that miR-125a was dramatically down-regulated during macrophage colony stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ligand (RANKL) induced osteoclastogenesis of circulating CD14+ peripheral blood mononuclear cells (PBMCs). Overexpression of miR-125a in CD14+ PBMCs inhibited osteoclastogenesis, while inhibition of miR-125a promoted osteoclastogenesis. TNF receptor-associated factor 6 (TRAF6), a transduction factor for RANKL/RANK/NFATc1 signal, was confirmed to be a target of miR-125a. EMSA and ChIP assays confirmed that NFATc1 bound to the promoter of the miR-125a. Overexpression of NFATc1 inhibited miR-125a transcription, and block of NFATc1 expression attenuated RANKL-regulated miR-125a transcription. Here, we reported that miR-125a played a biological function in osteoclastogenesis through a novel TRAF6/ NFATc1/miR-125a regulatory feedback loop. It suggests that regulation of miR-125a expression may be a potential strategy for ameliorating metabolic disease. - Highlights: • MiR-125a was significantly down-regulated in osteoclastogenesis of CD14+ PBMCs. • MiR-125a inhibited osteoclast differentiation by targeting TRAF6. • NFATc1 inhibited miR-125a transciption by binding to the promoter of miR-125a. • TRAF6/NFATc1 and miR-125a form a regulatory feedback loop in osteoclastogenesis.

  19. Public Participation

    Energy.gov [DOE]

    Maintaining an open dialog with the public is central to the mission of the Environmental Management Los Alamos Field Office (EM-LA).

  20. Geothermal Publications

    Energy.gov [DOE]

    Here you'll find the Department of Energy's most recent publications about enhanced geothermal systems (EGS) technologies and research and development activities.

  1. EC Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ElectricalSimulationsofSeriesandParallelPVArc-Faults(Presentation)admin2016-04-14T2... All Publications Placeholder Download Filename 39thPVSCElectricalSimulationsofSeriesa...

  2. Port Huron, MI Liquefied Natural Gas Exports (Million Cubic Feet...

    Energy Information Administration (EIA) (indexed site)

    (Million Cubic Feet) Port Huron, MI Liquefied Natural Gas Exports (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2013 1 2014 1 1 1 1 2 1 1 1 1 1 2015 1 1...

  3. Neutron scattering study of spin ordering and stripe pinning in superconducting <mi>La>1.93<mi>Sr>0.07<mi>CuO>4

    SciTech Connect

    Jacobsen, H.; Zaliznyak, I. A.; Savici, A. T.; Winn, B. L.; Chang, S.; Hücker, M.; Gu, G. D.; Tranquada, J. M.

    2015-11-20

    The relationships among charge order, spin fluctuations, and superconductivity in underdoped cuprates remain controversial. We use neutron scattering techniques to study these phenomena in <mi>La>1.93<mi>Sr>0.07<mi>CuO>4 a superconductor with a transition temperature of Tc = 20 K. At T<< Tc, we find incommensurate spin fluctuations with a quasielastic energy spectrum and no sign of a gap within the energy range from 0.2 to 15 meV. A weak elastic magnetic component grows below ~ 10 K, consistent with results from local probes. Regarding the atomic lattice, we have discovered unexpectedly strong fluctuations of the CuO6 octahedra about Cu-O bonds, which are associated with inequivalent O sites within the CuO2 planes. Moreover, we observed a weak elastic (3 30) superlattice peak that implies a reduced lattice symmetry. The presence of inequivalent O sites rationalizes various pieces of evidence for charge stripe order in underdoped La2-xSrxCuO4. The coexistence of superconductivity with quasi-static spin-stripe order suggests the presence of intertwined orders; however, the rotation of the stripe orientation away from the Cu-O bonds might be connected with evidence for a finite gap at the nodal points of the superconducting gap function.

  4. MiR-145 functions as a tumor suppressor targeting NUAK1 in human intrahepatic cholangiocarcinoma

    SciTech Connect

    Xiong, Xinkui; Sun, Daoyi; Chai, Hao; Shan, Wengang; Yu, Yue; Pu, Liyong; Cheng, Feng

    2015-09-18

    The dysregulation of micro (mi)RNAs is associated with cancer development. The miRNA miR-145 is downregulated in intrahepatic cholangiocarcinoma (ICC); however, its precise role in tumor progression has not yet been elucidated. Novel (nua) kinase family (NUAK)1 functions as an oncogene in various cancers and is a putative target of miR-145 regulation. In this study, we investigated the regulation of NUAK1 by miR-145 in ICC. We found that miR-145 level was significantly decreased in ICC tissue and cell lines, which corresponded with an increase in NUAK1 expression. NUAK1 was found to be a direct target of miR-145 regulation. The overexpression of miR-145 in ICC cell lines inhibited proliferation, growth, and invasion by suppressing NUAK1 expression, which was associated with a decrease in Akt signaling and matrix metalloproteinase protein expression. Similar results were observed by inhibiting NUAK1 expression. These results demonstrate that miR-145 can prevent ICC progression by targeting NUAK1 and its downstream effectors, and can therefore be useful for clinical diagnosis and targeted therapy of ICC. - Highlights: • MiR-145 suppresses ICC proliferation and invasion abilities. • We demonstrated that miR-145 directly targets NUAK1 in ICC. • MiR-145 expression in ICC was associated with Akt signaling and MMPs expression.

  5. Radiosensitizing Effects of Ectopic miR-101 on Non-Small-Cell Lung Cancer Cells Depend on the Endogenous miR-101 Level

    SciTech Connect

    Chen, Susie; Wang Hongyan; Ng, Wooi Loon; Curran, Walter J.; Wang Ya

    2011-12-01

    Purpose: Previously, we showed that ectopic miR-101 could sensitize human tumor cells to radiation by targeting ATM and DNA-PK catalytic subunit (DNA-PKcs) to inhibit DNA repair, as the endogenous miR-101 levels are low in tumors in general. However, the heterogeneity of human cancers may result in an exception. The purpose of this study was to test the hypothesis that a few tumor cell lines with a high level of endogenous miR-101 would prove less response to ectopic miR-101. Methods and Materials: Fourteeen non-small-cell lung cancer (NSCLC) cell lines and one immortalized non-malignant lung epithelial cell line (NL20) were used for comparing endogenous miR-101 levels by real-time reverse transcription-polymerase chain reaction. Based on the different miR-101 levels, four cell lines with different miR-101 levels were chosen for transfection with a green fluorescent protein-lentiviral plasmid encoding miR-101. The target protein levels were measured by using Western blotting. The radiosensitizing effects of ectopic miR-101 on these NSCLC cell lines were determined by a clonogenic assay and xenograft mouse model. Results: The endogenous miR-101 level was similar or lower in 13 NSCLC cell lines but was 11-fold higher in one cell line (H157) than in NL20 cells. Although ectopic miR-101 efficiently decreased the ATM and DNA-PKcs levels and increased the radiosensitization level in H1299, H1975, and A549 cells, it did not change the levels of the miR-101 targets or radiosensitivity in H157 cells. Similar results were observed in xenograft mice. Conclusions: A small number of NSCLC cell lines could have a high level of endogenous miR-101. The ectopic miR-101 was able to radiosensitize most NSCLC cells, except for the NSCLC cell lines that had a much higher endogenous miR-101 level. These results suggest that when we choose one miRNA as a therapeutic tool, the endogenous level of the miRNA in each tumor should be considered.

  6. Impact of Connectivity and Automation on Vehicle Energy Use | Argonne

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    National Laboratory Connectivity and Automation on Vehicle Energy Use Title Impact of Connectivity and Automation on Vehicle Energy Use Publication Type Conference Paper Year of Publication 2016 Authors Michel, P, Karbowski, D, Rousseau, A Conference Name SAE 2016 World Congress and Exhibition Date Published 04/2016 Publisher SAE International Conference Location Detroit, MI, USA Other Numbers SAE Technical Paper 2016-01-0152 Abstract Connectivity and automation are increasingly being

  7. Public Library.

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    d 1 Greet the metal turtles at the Mesa Public Library. 2 Take a tour of public art. 3 Start from Ashley Pond and find the smart house. 4 Test your electric personality at the Bradbury Science Museum. 5 Sit a spell in the Romero Cabin. 6 Walk the Rim Trail. 7 Dress up the Oppie and Groves statues. 8 Attend a Gordon's concert. 9 Put together a team for the mud volleyball tournament. 10 Hear authors speak or attend a gallery opening at Mesa Public Library. 11 Hike to the Cave Of The Winds. 12 Join

  8. ARM Publications Database

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    govPublicationsPublications Database Publications Database Submit a Publication Would your publication make a good research highlight? Submit one now. Comments? Need a change to an...

  9. EC Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Wolf-bioadmin2016-04-18T20:58:24+00:00 Popular Downloads Solar Energy Grid Integration ... All Publications Placeholder Download Filename Wolf-bio.pdf filesize 36.22 kB Version 1 ...

  10. EC Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    All Publications Go Back Order by: Title Date added Download count A toolkit for ... and Fuel Cells Program (1273) HyRAM 1.0.1 (421) HyRAM: A methodology and toolkit for ...

  11. Public Activities

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Art Gallery The Art Gallery in Wilson Hall is only open to the public before and after Arts, Lectures and Film Series events. The Gallery is closed to unescorted visitors at all...

  12. EC Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Hyperspectral Imaging admin 2016-04-18T20:58:24+00:00 Popular Downloads Solar Energy Grid ... All Publications Placeholder Download Filename Hyperspectral-Imaging.pdf filesize 1.49 MB ...

  13. Group Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications Background Literature Group: Publications, Annual Reports, Theses, Conference Proceedings Title Lead Author Reference and Link Novel technique to extract experimental symmetry free energy information for nuclear matter J. Mabiala Phys. Rev. C 92, 024605 (2015) Studying heavy-ion collisions with coverage near zero degrees with FAUST-QTS P. Cammarata NIMA 792 61 (2015) Isoscaling of heavy projectile residues and N/Z equilibration in peripheral heavy-ion collisions below the Fermi

  14. Publications | NISAC

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    NISACPublications content top Publications Posted by Admin on Feb 14, 2012 in | Comments 0 comments Reports Rapid Response Reports Sandia Reports Journal Articles Presentations Analyses Title Year Author(s) Type DownloadChemical supply chain modeling for analysis of homeland security events. Computers and Chemical Engineering (SAND2012-2956J)2013 Amy Sun; Mark Ehlen; Mark Pepple; Eric Eidson; Brian Jones Peer-Reviewed naREAcct: a... Read More Publications

  15. PPARγ inhibits ovarian cancer cells proliferation through upregulation of miR-125b

    SciTech Connect

    Luo, Shuang; Wang, Jidong; Ma, Ying; Yao, Zhenwei; Pan, Hongjuan

    2015-06-26

    miR-125b has essential roles in coordinating tumor proliferation, angiogenesis, invasiveness, metastasis and chemotherapy recurrence. In ovarian cancer miR-125b has been shown to be downregulated and acts as a tumor suppressor by targeting proto-oncogene BCL3. PPARγ, a multiple functional transcription factor, has been reported to have anti-tumor effects through inhibition of proliferation and induction of differentiation and apoptosis by targeting the tumor related genes. However, it is unclear whether miR-125b is regulated by PPARγ in ovarian cancer. In this study, we demonstrated that the miR-125b downregulated in ovarian cancer tissues and cell lines. Ligands-activated PPARγ suppressed proliferation of ovarian cancer cells and this PPARγ-induced growth inhibition is mediated by the upregulation of miR-125b. PPARγ promoted the expression of miR-125b by directly binding to the responsive element in miR-125b gene promoter region. Thus, our results suggest that PPARγ can induce growth suppression of ovarian cancer by upregulating miR-125b which inhibition of proto-oncogene BCL3. These findings will extend our understanding of the function of PPARγ in tumorigenesis and miR-125b may be a therapeutic intervention of ovarian cancer. - Highlights: • miR-125b is down-regulated in ovarian cancer tissues and cells. • PPARγ upregulates miR-125b and downregulates its target gene BCL3 expression. • Silence of miR-125b attenuates PPARγ-mediated growth suppression of ovarian cancer cells. • PPARγ promotes the transcription of miR-125b via binding to PPARE in miR-125b gene promoter region.

  16. "Title","Creator/Author","Publication Date","OSTI Identifier...

    Office of Scientific and Technical Information (OSTI)

    Phase diagram of Josephson junction between<mi>s>and<mi>s>superconductors in the dirty...

  17. DTE | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Link to project description http:www.intelligentutility.comarticle1101energy-storage-nrel DTE is a company located in Detroit, MI. References "DTE Energy"...

  18. A High Temperature Direct Vehicle Exhaust Flowmeter for Heavy Duty Diesel Emission Measurements.

    Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  19. Thermoelectric Generator Development for Automotive Waste Heat Recovery

    Office of Energy Efficiency and Renewable Energy (EERE)

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  20. Efficiency Considerations of Diesel Premixed Charge Compression Ignition Combustion

    Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  1. Development of Artificial Ash Accelerated Accumulation Test

    Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  2. Heavy-Duty Powertrain DevelopmentCurrent Status and Future Opportunities

    Office of Energy Efficiency and Renewable Energy (EERE)

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  3. High-Efficiency Engine Technologies Session Introduction

    Office of Energy Efficiency and Renewable Energy (EERE)

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  4. Development of HC-SCR System Using Diesel Fuel as a Reductant

    Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  5. New Developments in Titania-Based Catalysts for Selective Catalytic Reduction of NOx

    Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  6. Novel Catalysts for Nox Reduction with Reductants Produced in-Situ

    Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  7. Power Generating Stationary Engines Nox Control: A Closed Loop Control Technology

    Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  8. Organic Rankine Cycle Turbine for Exhaust Energy Recovery in a Heavy Truck Engine

    Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  9. Cylinder Head Gasket with Integrated Combustion Pressure Sensors

    Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  10. SwRI's HEDGE Technology for High Efficiency, Low Emissions Gasoline Engines

    Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  11. Advanced Radio Frequency-Based Sensors for Monitoring Diesel Particulate Filter Loading and Regeneration

    Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  12. Oxidation State Optimization for Maximum Efficiency of NOx Adsorber Catalysts

    Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  13. Diesel Particulate Oxidation Model: Combined Effects of Fixed & Volatile Carbon

    Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  14. Slide 1

    Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  15. An Analytical Approach for Tail-Pipe Emissions Estimation with...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    with Coupled Engine and Aftertreatment System Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September ...

  16. Validation of a Small Engine Based Procedure for Studying Performance...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    for Engine Friction Reduction and Durable Design Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September ...

  17. Heritage Garden | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Energy Developer Heritage Sustainable Energy Energy Purchaser Consumers Energy Detroit Edison Location Garden MI Coordinates 45.776334, -86.5527241 Show Map Loading...

  18. AVL Powertrain Engineering | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    successadvisor.html AVL Powertrain Engineering is a company located in Detroit, MI. References "AVL" Retrieved from "http:en.openei.orgw...

  19. General Motors | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Motors Jump to: navigation, search Name: General Motors Place: Detroit, MI Website: www.generalmotors.com References: General Motors1 Information About Partnership with NREL...

  20. Reducing fuel consumption on the field, by continuously measuring fuel quality on electronically fuel injected engines.

    Office of Energy Efficiency and Renewable Energy (EERE)

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  1. The Impact of Using Derived Fuel Consumption Maps to Predict Fuel Consumption

    Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  2. Other Participants 2003 | U.S. DOE Office of Science (SC)

    Office of Science (SC)

    ... , Pullman , WA 51. Randolph School , Huntsville , AL 52. Renaissance High School , Detroit , MI 53. Saratoga Springs High School , Saratoga Springs , NY 54. Sault Area High School ...

  3. Performance of a High Speed Indirect Injection Diesel Engine with Poultry Fat Bio-Diesel

    Office of Energy Efficiency and Renewable Energy (EERE)

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  4. Impact of Biodiesel Metals on the Performance and Durability of DOC and DPF Technologies

    Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  5. Improving Diesel Engine Sweet-spot Efficiency and Adapting it to Improve Duty-cycle MPG- plus Increasing Propulsion and Reducing Cost

    Office of Energy Efficiency and Renewable Energy (EERE)

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  6. A Simple Approach of Tuning Catalytic Activity of MFI-Zeolites for Low-Temperature SCR of NOx

    Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  7. Thermal Energy Storage Technology for Transportation and Other Applications D. Bank, M. Maurer, J. Penkala, K. Sehanobish, A. Soukhojak

    Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  8. Advantages of Oxygenates Fuels over Gasoline in Direct Injection Spark Ignition Engines

    Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  9. Performance of an Organic Rankine Cycle Waste Heat Recovery System for Light Duty Diesel Engines

    Office of Energy Efficiency and Renewable Energy (EERE)

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  10. Development of a Thermal Enhancer ’ for Combined Partial Range Burning and Hydrocarbon Dosing

    Office of Energy Efficiency and Renewable Energy (EERE)

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  11. An Analytical Approach for Tail-Pipe Emissions Estimation with Coupled Engine and Aftertreatment System

    Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  12. Development of Optimal Catalyst Designs and Operating Strategies for Lean NOx Reduction in Coupled LNT-SCR Systems

    Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  13. Combustion and Emissions Performance of Dual-Fuel Gasoline and Diesel HECC on a Multi-Cylinder Light Duty Diesel Engine

    Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  14. Analyses Guided Optimization of Wide Range and High Efficiency Turbocharger Compressor

    Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  15. A University Consortium on High Pressure, Lean Combustion for Efficient and Clean IC Engines (UM- lead, MIT, UCB)

    Office of Energy Efficiency and Renewable Energy (EERE)

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  16. Integrated Mathematical Modeling Software Series of Vehicle Propulsion System: (1) Tractive Effort (T sub ew) of Vehicle Road Wheel/Track Sprocket

    Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  17. Improving the NOx-CO2 Trade-Off of an HCCI Engine using a Multi...

    Office of Scientific and Technical Information (OSTI)

    16-19, 2007 in Detroit, MI. Research Org: Sandia National Laboratories (SNL-CA), Livermore, CA (United States) Sponsoring Org: USDOE National Nuclear Security Administration ...

  18. Detection of Ammonia Slip Using NOx Sensor Signal Processing

    Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  19. Potential Health and Environmental Impact from Emerging Technologies and Fuels: A report from the Health Effects Insitute

    Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  20. Magnesium Replacement of Aluminum Cast Components in a Production V6 Engine to Effect Cost-Effective Mass Reduction

    Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  1. Department of Energy Announces Advanced Vehicle Technology Competition...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ... of Washington (Seattle, WA) University of Waterloo (Waterloo, Ontario, Canada) Virginia Tech (Blacksburg, VA) Wayne State University (Detroit, MI) These teams will explore a ...

  2. Performance of the Low-Efficiency Diesel Particulate Filter for Diesel PM Reduction

    Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  3. Development of Urea Dosing System for 10 Liter Heavy Duty Diesel Engine Powered Vehicle

    Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  4. Partial-Flow Diesel Particulate Filter of Sintered Metal Fiber Fleece

    Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  5. An Accelerated Aging Method for Diesel Exhaust Aftertreatment Systems

    Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  6. Optical Measurement Methods used in Calibration and Validation of Modeled Injection Spray Characteristics

    Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  7. Evaluation of Variable Compression Ratio on Energy Efficiency

    Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  8. Efficient Thermally Variable Cooling System

    Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  9. A Thermoelectric Generator with an Intermediate Heat Exchanger for Automotive Waste Heat Recovery System

    Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  10. An Experimental Investigation of Low Octane Gasoline in Diesel Engines

    Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  11. Catalyst by Design- Theoretical, Nanostructural, and Experimental Studies of Emission Treatment Catalyst

    Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  12. Thermoelectric Conversion of Wate Heat to Electricity in an IC Engine Powered Vehicle

    Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  13. Liquid Propane Injection Applications

    Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  14. Sources of UHC and CO in Low Temperature Automotive Diesel Combustion Systems

    Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  15. An Engine System Approach to Exhaust Waste Heat Recovery

    Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  16. Validation of a Small Engine Based Procedure for Studying Performance of Engine Lube Oils, Ionic Liquids as Lubricants and/or Lubricant Additives, Opportunities for Engine Friction Reduction and Durable Design

    Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  17. Influence of Mild Hybridization on Performance and emission in a 4-Cylinder, In-Line Common Rail Diesel Engine

    Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  18. Factors Impacting EGR Cooler Fouling- Main Effects and Interactions

    Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  19. Modular Low Cost High Energy Exhaust Heat Thermoelectric Generator with Closed-Loop Exhaust By-Pass System

    Office of Energy Efficiency and Renewable Energy (EERE)

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  20. Slide Title

    Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  1. Reductant Chemistry during LNT Regeneration for a Lean Gasoline Engine

    Office of Energy Efficiency and Renewable Energy (EERE)

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  2. Integrated Nozzle Flow, Spray, Combustion, & Emission Modeling using KH-ACT Primary Breakup Model & Detailed Chemistry

    Office of Energy Efficiency and Renewable Energy (EERE)

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  3. Modeling Combustion Control for High Power Diesel Mode Switching

    Energy.gov [DOE]

    Poster presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  4. Increased Engine Efficiency via Advancements in Engine Combustion Systems

    Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  5. Development of an SI DI Ethanol Optimized Flex Fuel Engine Using Advanced Valvetrain

    Office of Energy Efficiency and Renewable Energy (EERE)

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  6. Two in One: SCR on Filter

    Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  7. Functionality of Commercial NOx Storage-Reduction Catalysts and the Development of a Representative Model

    Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  8. Function Specific Analysis of the Thermal Durability of Cu-Zeolite SCR Catalyst

    Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  9. Vehicular Thermoelectrics: The New Green Technology

    Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  10. Load Expansion of Stoichiometric HCCI Using Spark Assist and Hydraulic Valve Actuation

    Energy.gov [DOE]

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  11. Progress toward Development of a High-Efficiency Zonal Thermoelectric HVAC System for Automotive Applications

    Office of Energy Efficiency and Renewable Energy (EERE)

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  12. Advanced Diesel Combustion with Low Hydrocarbon and Carbon Monoxide Emissions

    Energy.gov [DOE]

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010.

  13. Workbook Contents

    Energy Information Administration (EIA) (indexed site)

    ,"Worksheet Name","Description"," Of Series","Frequency","Latest Data for" ,"Data 1","Detroit, MI Natural Gas Pipeline Exports to Canada (MMcf)",1,"Annual",2014 ,"Release...

  14. Mr. Shaun Maloney :

    Office of Legacy Management (LM)

    ... Detroit, MI 48232 Chambersburg Engineering Co. Chambersburg, PA Ithaca Gun Co. Ithaca, NY New England Materials Lab., Inc. Teledyne Materials' . Medford, MA NRC Equipment Co. . -. ...

  15. Genome-Wide Analysis of miRNA targets in Brachypodium and Biomass Energy Crops

    SciTech Connect

    Green, Pamela J.

    2015-08-11

    MicroRNAs (miRNAs) contribute to the control of numerous biological processes through the regulation of specific target mRNAs. Although the identities of these targets are essential to elucidate miRNA function, the targets are much more difficult to identify than the small RNAs themselves. Before this work, we pioneered the genome-wide identification of the targets of Arabidopsis miRNAs using an approach called PARE (German et al., Nature Biotech. 2008; Nature Protocols, 2009). Under this project, we applied PARE to Brachypodium distachyon (Brachypodium), a model plant in the Poaceae family, which includes the major food grain and bioenergy crops. Through in-depth global analysis and examination of specific examples, this research greatly expanded our knowledge of miRNAs and target RNAs of Brachypodium. New regulation in response to environmental stress or tissue type was found, and many new miRNAs were discovered. More than 260 targets of new and known miRNAs with PARE sequences at the precise sites of miRNA-guided cleavage were identified and characterized. Combining PARE data with the small RNA data also identified the miRNAs responsible for initiating approximately 500 phased loci, including one of the novel miRNAs. PARE analysis also revealed that differentially expressed miRNAs in the same family guide specific target RNA cleavage in a correspondingly tissue-preferential manner. The project included generation of small RNA and PARE resources for bioenergy crops, to facilitate ongoing discovery of conserved miRNA-target RNA regulation. By associating specific miRNA-target RNA pairs with known physiological functions, the research provides insights about gene regulation in different tissues and in response to environmental stress. This, and release of new PARE and small RNA data sets should contribute basic knowledge to enhance breeding and may suggest new strategies for improvement of biomass energy crops.

  16. DLEU2, frequently deleted in malignancy, functions as a critical host gene of the cell cycle inhibitory microRNAs miR-15a and miR-16-1

    SciTech Connect

    Lerner, Mikael; Harada, Masako; Loven, Jakob; Castro, Juan; Davis, Zadie; Oscier, David; Henriksson, Marie; Sangfelt, Olle; Grander, Dan; Corcoran, Martin M.

    2009-10-15

    The microRNAs miR-15a and miR-16-1 are downregulated in multiple tumor types and are frequently deleted in chronic lymphocytic leukemia (CLL), myeloma and mantle cell lymphoma. Despite their abundance in most cells the transcriptional regulation of miR-15a/16-1 remains unclear. Here we demonstrate that the putative tumor suppressor DLEU2 acts as a host gene of these microRNAs. Mature miR-15a/miR-16-1 are produced in a Drosha-dependent process from DLEU2 and binding of the Myc oncoprotein to two alterative DLEU2 promoters represses both the host gene transcript and levels of mature miR-15a/miR-16-1. In line with a functional role for DLEU2 in the expression of the microRNAs, the miR-15a/miR-16-1 locus is retained in four CLL cases that delete both promoters of this gene and expression analysis indicates that this leads to functional loss of mature miR-15a/16-1. We additionally show that DLEU2 negatively regulates the G1 Cyclins E1 and D1 through miR-15a/miR-16-1 and provide evidence that these oncoproteins are subject to miR-15a/miR-16-1-mediated repression under normal conditions. We also demonstrate that DLEU2 overexpression blocks cellular proliferation and inhibits the colony-forming ability of tumor cell lines in a miR-15a/miR-16-1-dependent way. Together the data illuminate how inactivation of DLEU2 promotes cell proliferation and tumor progression through functional loss of miR-15a/miR-16-1.

  17. Microfluidic Molecular Assay Platform for the Detection of miRNAs...

    Office of Scientific and Technical Information (OSTI)

    Article: Microfluidic Molecular Assay Platform for the Detection of miRNAs, mRNAs, Proteins, and Post-translational Modifications at Single-cell Resolution. Citation Details...

  18. DOE - Office of Legacy Management -- Baker-Perkins Co - MI 13

    Office of Legacy Management (LM)

    Site Disposition: Eliminated - Potential for contamination remote based on limited scope of activities at the site MI.13-3 Radioactive Materials Handled: Yes Primary ...

  19. miR-4295 promotes cell proliferation and invasion in anaplastic thyroid carcinoma via CDKN1A

    SciTech Connect

    Shao, Mingchen; Geng, Yiwei; Lu, Peng; Xi, Ying; Wei, Sidong; Wang, Liuxing; Fan, Qingxia; Ma, Wang

    2015-09-04

    MicroRNAs (miRNAs) play important roles in the pathogenesis of many types of cancers by negatively regulating gene expression at posttranscriptional level. However, the role of microRNAs in anaplastic thyroid carcinoma (ATC), has remained elusive. Here, we identified that miR-4295 promotes ATC cell proliferation by negatively regulates its target gene CDKN1A. In ATC cell lines, CCK-8 proliferation assay indicated that the cell proliferation was promoted by miR-4295, while miR-4295 inhibitor significantly inhibited the cell proliferation. Transwell assay showed that miR-4295 mimics significantly promoted the migration and invasion of ATC cells, whereas miR-4295 inhibitors significantly reduced cell migration and invasion. luciferase assays confirmed that miR-4295 directly bound to the 3'untranslated region of CDKN1A, and western blotting showed that miR-4295 suppressed the expression of CDKN1A at the protein levels. This study indicated that miR-4295 negatively regulates CDKN1A and promotes proliferation and invasion of ATC cell lines. Thus, miR-4295 may represent a potential therapeutic target for ATC intervention. - Highlights: • miR-4295 mimics promote the proliferation and invasion of ATC cells. • miR-4295 inhibitors inhibit the proliferation and invasion of ATC cells. • miR-4295 targets 3′UTR of CDKN1A in ATC cells. • miR-4295 negatively regulates CDKN1A in ATC cells.

  20. Publications - SRSCRO

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Renewing the Nuclear Workforce Renewing the Nuclear Workforce Publications NWI Regional Programs 2-PAGE Overview (Revised 6_2015) Regional Nuclear Workforce Development in the Central Savannah River Area (June 2010) Nuclear Workforce Initiative®: Filling a Critical Career Need (November 2009) Nuclear Workforce Summit - Summary Report (June 2009) Booz Allen Hamilton Nuclear Workforce Survey Report (June 2009) Ensuring a Skilled Workforce for the Nuclear Renaissance (Nov 2008) Types of Nuclear

  1. Public Lecture

    ScienceCinema

    None

    2016-07-12

    An outreach activity is being organized by the Turkish community at CERN, on 5 June 2010 at CERN Main Auditorium. The activity consists of several talks that will take 1.5h in total. The main goal of the activity will be describing the CERN based activities and experiments as well as stimulating the public's attention to the science related topics. We believe the wide communication of the event has certain advantages especially for the proceeding membership process of Turkey.

  2. Groundwater protection for the NuMI project

    SciTech Connect

    Wehmann, A.; Smart, W.; Menary, S.; Hylen, J.; Childress, S.

    1997-10-01

    The physics requirements for the long base line neutrino oscillation experiment MINOS dictate that the NuMI beamline be located in the aquifer at Fermilab. A methodology is described for calculating the level of radioactivation of groundwater caused by operation of this beamline. A conceptual shielding design for the 750 meter long decay pipe is investigated which would reduce radioactivation of the groundwater to below government standards. More economical shielding designs to meet these requirements are being explored. Also, information on local geology, hydrogeology, government standards, and a glossary have been included.

  3. Publications | Photosynthetic Antenna Research Center

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications Publications View: Publications by First Author Publications by Year Also see: Conference Abstracts Other Publications Facilities Publications Publications by First...

  4. PUBLIC SUBMISSION

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    ANDREW%20J.%20FERLIC_cover_DRAFT-0002.html[2/3/2012 12:37:00 PM] PUBLIC SUBMISSION As of: February 03, 2012 Received: December 29, 2011 Status: Pending_Post Tracking No. 80f8ad44 Comments Due: January 20, 2012 Submission Type: Web Docket: DOE-HQ-2012-0004 U.S. Department of Energy Audit Guidance: For-Profit Recipients Comment On: DOE-HQ-2012-0004-0001 Audit Guidance: For-Profit Recipients Document: DOE-HQ-2012-0004-DRAFT-0002 Comment on FR Doc # 2011-32622 Submitter Information Name: ANDREW J.

  5. PUBLIC SUBMISSION

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    2-2012%2010-10-11-600/Document%20List%2003-02-2012%2010-10-11-600_docs/Martin%20WeblerCover_DRAFT-0004.html[2/3/2012 12:40:30 PM] PUBLIC SUBMISSION As of: February 03, 2012 Received: January 05, 2012 Status: Pending_Post Tracking No. 80f8e384 Comments Due: January 20, 2012 Submission Type: Web Docket: DOE-HQ-2012-0004 U.S. Department of Energy Audit Guidance: For-Profit Recipients Comment On: DOE-HQ-2012-0004-0001 Audit Guidance: For-Profit Recipients Document: DOE-HQ-2012-0004-DRAFT-0004

  6. MiR-153 inhibits migration and invasion of human non-small-cell lung cancer by targeting ADAM19

    SciTech Connect

    Shan, Nianxi; Shen, Liangfang; Wang, Jun; He, Dan; Duan, Chaojun

    2015-01-02

    Highlights: • Decreased miR-153 and up-regulated ADAM19 are correlated with NSCLC pathology. • MiR-153 inhibits the proliferation and migration and invasion of NSCLC cells in vitro. • ADAM19 is a direct target of miR-153. • ADAM19 is involved in miR-153-suppressed migration and invasion of NSCLC cells. - Abstract: MiR-153 was reported to be dysregulated in some human cancers. However, the function and mechanism of miR-153 in lung cancer cells remains unknown. In this study, we investigated the role of miR-153 in human non-small-cell lung cancer (NSCLC). Using qRT-PCR, we demonstrated that miR-153 was significantly decreased in clinical NSCLC tissues and cell lines, and downregulation of miR-153 was significantly correlated with lymph node status. We further found that ectopic expression of miR-153 significantly inhibited the proliferation and migration and invasion of NSCLC cells in vitro, suggesting that miR-153 may be a novel tumor suppressor in NSCLC. Further integrated analysis revealed that ADAM19 is as a direct and functional target of miR-153. Luciferase reporter assay demonstrated that miR-153 directly targeted 3′UTR of ADAM19, and correlation analysis revealed an inverse correlation between miR-153 and ADAM19 mRNA levels in clinical NSCLC tissues. Knockdown of ADAM19 inhibited migration and invasion of NSCLC cells which was similar with effects of overexpression of miR-153, while overexpression of ADAM19 attenuated the function of miR-153 in NSCLC cells. Taken together, our results highlight the significance of miR-153 and ADAM19 in the development and progression of NSCLC.

  7. miR-129 suppresses tumor cell growth and invasion by targeting PAK5 in hepatocellular carcinoma

    SciTech Connect

    Zhai, Jian; Qu, Shuping; Li, Xiaowei; Zhong, Jiaming; Chen, Xiaoxia; Qu, Zengqiang; Wu, Dong

    2015-08-14

    Emerging evidence suggests that microRNAs (miRNAs) play important roles in regulating HCC development and progression; however, the mechanisms by which their specific functions and mechanisms remained to be further explored. miR-129 has been reported in gastric cancers, lung cancer and colon cancer. In this study, we disclosed a new tumor suppresser function of miR-129 in HCC. We also found the downregulation of miR-129 occurred in nearly 3/4 of the tumors examined (56/76) compared with adjacent nontumorous tissues, which was more importantly, correlated to the advanced stage and vascular invasion. We then demonstrated that miR-129 overexpression attenuated HCC cells proliferation and invasion, inducing apoptosis in vitro. Moreover, we used miR-129 antagonist and found that anti-miR-129 promoted HCC cells malignant phenotypes. Mechanistically, our further investigations revealed that miR-129 suppressed cell proliferation and invasion by targeting the 3’-untranslated region of PAK5, as well as miR-129 silencing up-regulated PAK5 expression. Moreover, miR-129 expression was inversely correlated with PAK5 expression in 76 cases of HCC samples. RNA interference of PAK5 attenuated anti-miR-129 mediated cell proliferation and invasion in HCC cells. Taken together, these results demonstrated that miR-129 suppressed tumorigenesis and progression by directly targeting PAK5, defining miR-129 as a potential treatment target for HCC. - Highlights: • Decreased of miR-129 is found in HCC and associated with advanced stage and metastasis. • miR-129 suppresses proliferation and invasion of HCC cells. • miR-129 directly targets the 3′ UTR of PAK5 and diminishes PAK5 expression. • PAK5 is involved in miR-129 mediated suppression functions.

  8. Transcriptional regulation of miR-146b by C/EBPβ LAP2 in esophageal cancer cells

    SciTech Connect

    Li, Junxia; Shan, Fabo; Xiong, Gang; Wang, Ju-Ming; Wang, Wen-Lin; Xu, Xueqing; Bai, Yun

    2014-03-28

    Highlights: • MiR-146b promotes esophageal cancer cell proliferation. • MiR-146b inhibits esophageal cancer cell apoptosis. • C/EBPβ directly binds to miR-146b promoter conserved region. • MiR-146b is up-regulated by C/EBPβ LAP2 transcriptional activation. - Abstract: Recent clinical study indicated that up-regulation of miR-146b was associated with poor overall survival of patients in esophageal squamous cell carcinoma. However, the underlying mechanism of miR-146b dysregulation remains to be explored. Here we report that miR-146b promotes cell proliferation and inhibits cell apoptosis in esophageal cancer cell lines. Mechanismly, two C/EBPβ binding motifs are located in the miR-146b promoter conserved region. Among the three isoforms of C/EBPβ, C/EBPβ LAP2 positively regulated miR-146b expression and increases miR-146b levels in a dose-dependent manner through transcription activation of miR-146b gene. Together, these results suggest a miR-146b regulatory mechanism involving C/EBPβ, which may contribute to the up-regulation of miR-146b in esophageal squamous cell carcinoma.

  9. miR-1297 mediates PTEN expression and contributes to cell progression in LSCC

    SciTech Connect

    Li, Xin; Wang, Hong-liang; Peng, Xin; Zhou, Hui-fang; Wang, Xin

    2012-10-19

    Highlights: Black-Right-Pointing-Pointer miR-1297 was found to be overexpressed in LSCC and contribute to the cell progression. Black-Right-Pointing-Pointer PTEN was confirmed to be a target gene of miR-1297. Black-Right-Pointing-Pointer Downregulation of PTEN can rescue the proliferation and invasion ability of miR-1297 downregulated Hep-2 cells. Black-Right-Pointing-Pointer Downregulation of miR-1297 inhibits tumor growth in vivo. -- Abstract: MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression after transcription, and are involved in cancer development. Laryngeal squamous cell carcinoma (LSCC) is one of the most common malignant neoplasms with increasing incidence in recent years. In this paper, we report the overexpression of miR-1297 in LSCC and Hep-2 cells. In addition, PTEN was identified to be directly regulated by miR-1297 through western blot and luciferase activity assay. Furthermore, downregulation of miR-1297 in Hep-2 cells was shown to inhibit cancer cell proliferation, migration, and tumor genesis. Our results document a new epigenetic mechanism for PTEN regulation in LSCC, which is crucial for the development of these tumors.

  10. miR-30a suppresses breast cancer cell proliferation and migration by targeting Eya2

    SciTech Connect

    Fu, Jing; Xu, Xiaojie; Kang, Lei; Zhou, Liying; Wang, Shibin; Lu, Juming; Cheng, Long; Fan, Zhongyi; Yuan, Bin; Tian, Peirong; Zheng, Xiaofei; Yu, Chengze; Ye, Qinong; Lv, Zhaohui

    2014-03-07

    Highlights: • miR-30a represses Eya2 expression by binding to the 3′-untranslated region of Eya2. • The miR-30a/EYA2 axis regulates breast cancer cell proliferation and migration. • The miR-30a/EYA2 axis modulates G1/S cell cycle progression. • The miR-30a/EYA2 axis is dysregulated in breast cancer patients. - Abstract: Eye absent (Eya) proteins are involved in cell fate determination in a broad spectrum of cells and tissues. Aberrant expression of Eya2 has been documented in a variety of cancers and correlates with clinical outcome. However, whether microRNAs (miRNAs) can regulate Eya2 expression remains unknown. Here, we show that miR-30a represses Eya2 expression by binding to the 3′-untranslated region of Eya2. Overexpression of Eya2 in miR-30a-transfected breast cancer cells effectively rescued the inhibition of cell proliferation and migration caused by miR-30a. Knockdown of Eya2 by small-interfering RNA (siRNA) in breast cancer cells mimicked the effect induced by miR-30a and abolished the ability of miR-30a to regulate breast cancer cell proliferation and migration. The miR-30a/Eya2 axis could regulate G1/S cell cycle progression, accompanied by the modulation of expression of cell cycle-related proteins, including cyclin A, cyclin D1, cyclin E, and c-Myc. Moreover, miR-30a expression was downregulated in breast cancer patients, and negatively correlated with Eya2, which was upregulated in breast cancer patients. These data suggest that the miR-30a/Eya2 axis may play an important role in breast cancer development and progression and that miR-30a activation or Eya2 inhibition may be a useful strategy for cancer treatment.

  11. miR-21 modulates resistance of HR-HPV positive cervical cancer cells to radiation through targeting LATS1

    SciTech Connect

    Liu, Shikai; Song, Lili Zhang, Liang; Zeng, Saitian; Gao, Fangyuan

    2015-04-17

    Although multiple miRNAs are found involved in radioresistance development in HR-HPV positive (+) cervical cancer, only limited studies explored the regulative mechanism of the miRNAs. miR-21 is one of the miRNAs significantly upregulated in HR-HPV (+) cervical cancer is also significantly associated with radioresistance. However, the detailed regulative network of miR-21 in radioresistance is still not clear. In this study, we confirmed that miR-21 overexpression was associated with higher level of radioresistance in HR-HPV (+) cervical cancer patients and thus decided to further explore its role. Findings of this study found miR-21 can negatively affect radiosensitivity of HR-HPV (+) cervical cancer cells and decrease radiation induced G2/M block and increase S phase accumulation. By using dual luciferase assay, we verified a binding site between miR-21 and 3′-UTR of large tumor suppressor kinase 1 (LATS1). Through direct binding, miR-21 can regulate LATS1 expression in cervical cancer cells. LATS1 overexpression can reverse miR-21 induced higher colony formation rate and also reduced miR-21 induced S phase accumulation and G2/M phase block reduction under radiation treatment. These results suggested that miR-21-LATS1 axis plays an important role in regulating radiosensitivity. - Highlights: • miR-21 is highly expressed in HR-HPV (+) radioresistant cervical cancer patients. • miR-21 can negatively affect radiosensitivity of HR-HPV (+) cervical cancer cells. • miR-21 can decrease radiation induced G2/M block and increase S phase accumulation. • miR-21 modulates radiosensitivity cervical cancer cell by directly targeting LATS1.

  12. miR-92a is upregulated in cervical cancer and promotes cell proliferation and invasion by targeting FBXW7

    SciTech Connect

    Zhou, Chuanyi; Shen, Liangfang; Mao, Lei; Wang, Bing; Li, Yang; Yu, Huizhi

    2015-02-27

    MicroRNAs (miRNAs) are involved in the cervical carcinogenesis and progression. In this study, we investigated the role of miR-92a in progression and invasion of cervical cancer. MiR-92a was significantly upregulated in cervical cancer tissues and cell lines. Overexpression of miR-92a led to remarkably enhanced proliferation by promoting cell cycle transition from G1 to S phase and significantly enhanced invasion of cervical cancer cells, while its knockdown significantly reversed these cellular events. Bioinformatics analysis suggested F-box and WD repeat domain-containing 7 (FBXW7) as a novel target of miR-92a, and miR-92a suppressed the expression level of FBXW7 mRNA by direct binding to its 3′-untranslated region (3′UTR). Expression of miR-92a was negatively correlated with FBXW7 in cervical cancer tissues. Furthermore, Silencing of FBXW7 counteracted the effects of miR-92a suppression, while its overexpression reversed oncogenic effects of miR-92a. Together, these findings indicate that miR-92a acts as an onco-miRNA and may contribute to the progression and invasion of cervical cancer, suggesting miR-92a as a potential novel diagnostic and therapeutic target of cervical cancer. - Highlights: • miR-92a is elevated in cervical cancer tissues and cell lines. • miR-92a promotes cervical cancer cell proliferation, cell cycle transition from G1 to S phase and invasion. • FBXW7 is a direct target of miR-92a. • FBXW7 counteracts the oncogenic effects of miR-92a on cervical cancer cells.

  13. Marysville, MI Natural Gas Pipeline Imports From Canada (Million Cubic

    Energy Information Administration (EIA) (indexed site)

    Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 10 1,827 135 2000's NA NA 74 0 303 0 24 876 2,252 5,651 2010's 5,694 9,946 8,099 2,337 4,650 1,961 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Natural Gas Pipeline Imports by Point of Entry Marysville, MI Natural Gas Imports by Pipeli

  14. Marysville, MI Natural Gas Pipeline Imports From Canada (Dollars per

    Energy Information Administration (EIA) (indexed site)

    Thousand Cubic Feet) Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 3.48 2.17 2.06 2000's NA NA 3.95 -- 7.80 -- 7.07 7.59 8.59 3.80 2010's 4.44 4.42 2.99 4.15 6.86 2.73 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Price of Natural Gas Pipeline Imports by Point of Entry Marysville, MI Natural Gas

  15. NuMI proton kicker extraction magnet termination resistor system

    SciTech Connect

    Reeves, S.R.; Jensen, C.C.; /Fermilab

    2005-05-01

    The temperature stability of the kicker magnet termination resistor assembly directly affects the field flatness and amplitude stability. Comprehensive thermal enhancements were made to the existing Main Injector resistor assembly design to satisfy NuMI performance specifications. Additionally, a fluid-processing system utilizing Fluorinert{reg_sign} FC-77 high-voltage dielectric was built to precisely control the setpoint temperature of the resistor assembly from 70 to 120F, required to maintain constant resistance during changing operational modes. The Fluorinert{reg_sign} must be continually processed to remove hazardous breakdown products caused by radiation exposure to prevent chemical attack of system components. Design details of the termination resistor assembly and Fluorinert{reg_sign} processing system are described. Early performance results will be presented.

  16. Non-canonical microRNAs miR-320 and miR-702 promote proliferation in Dgcr8-deficient embryonic stem cells

    SciTech Connect

    Kim, Byeong-Moo; Choi, Michael Y.

    2012-09-21

    Highlights: Black-Right-Pointing-Pointer Embryonic stem cells (ESCs) lacking non-canonical miRNAs proliferate slower. Black-Right-Pointing-Pointer miR-320 and miR-702 are two non-canonical miRNAs expressed in ESCs. Black-Right-Pointing-Pointer miR-320 and miR-702 promote proliferation of Dgcr8-deficient ESCs. Black-Right-Pointing-Pointer miR-320 targets p57 and helps to release Dgcr8-deficient ESCs from G1 arrest. Black-Right-Pointing-Pointer miR-702 targets p21 and helps to release Dgcr8-deficient ESCs from G1 arrest. -- Abstract: MicroRNAs are known to contribute significantly to stem cell phenotype by post-transcriptionally regulating gene expression. Most of our knowledge of microRNAs comes from the study of canonical microRNAs that require two sequential cleavages by the Drosha/Dgcr8 heterodimer and Dicer to generate mature products. In contrast, non-canonical microRNAs bypass the cleavage by the Drosha/Dgcr8 heterodimer within the nucleus but still require cytoplasmic cleavage by Dicer. The function of non-canonical microRNAs in embryonic stem cells (ESCs) remains obscure. It has been hypothesized that non-canonical microRNAs have important roles in ESCs based upon the phenotypes of ESC lines that lack these specific classes of microRNAs; Dicer-deficient ESCs lacking both canonical and non-canonical microRNAs have much more severe proliferation defect than Dgcr8-deficient ESCs lacking only canonical microRNAs. Using these cell lines, we identified two non-canonical microRNAs, miR-320 and miR-702, that promote proliferation of Dgcr8-deficient ESCs by releasing them from G1 arrest. This is accomplished by targeting the 3 Prime -untranslated regions of the cell cycle inhibitors p57 and p21 and thereby inhibiting their expression. This is the first report of the crucial role of non-canonical microRNAs in ESCs.

  17. miR-182 targets CHL1 and controls tumor growth and invasion in papillary thyroid carcinoma

    SciTech Connect

    Zhu, Hongling; Fang, Jin; Zhang, Jichen; Zhao, Zefei; Liu, Lianyong; Wang, Jingnan; Xi, Qian; Gu, Mingjun

    2014-07-18

    Highlights: miR-182 and CHL1 expression patterns are negatively correlated. CHL1 is a direct target of miR-182 in PTC cells. miR-182 suppression inhibits PTC cell growth and invasion. CHL1 is involved in miR-182-mediated cell behavior. - Abstract: In this study, we investigated the role and underlying mechanism of action of miR-182 in papillary thyroid carcinoma (PTC). Bioinformatics analysis revealed close homolog of LI (CHL1) as a potential target of miR-182. Upregulation of miR-182 was significantly correlated with CHL1 downregulation in human PTC tissues and cell lines. miR-182 suppressed the expression of CHL1 mRNA through direct targeting of the 3?-untranslated region (3?-UTR). Downregulation of miR-182 suppressed growth and invasion of PTC cells. Silencing of CHL1 counteracted the effects of miR-182 suppression, while its overexpression mimicked these effects. Our data collectively indicate that miR-182 in PTC promotes cell proliferation and invasion through direct suppression of CHL1, supporting the potential utility of miR-182 inhibition as a novel therapeutic strategy against PTC.

  18. Tools for Public Information

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Tools for Public Information Tools for Public Information A list of resources for the public, including Intellus, an online tool that provides transparency and accessibility to the ...

  19. ARM Publications Database

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    DatabaseSearch Publications Database Search Submit a Publication Would your publication make a good research highlight? Submit one now. Comments? Need a change to an existing...

  20. ARM Publications Database

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    DatabaseSearchTips Publications Database Search Submit a Publication Would your publication make a good research highlight? Submit one now. Comments? Need a change to an existing...

  1. Neutron and Nuclear Science Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications Recent publications related to neutron and nuclear science at LANSCE. Neutron and Nuclear Science Publications Chi-Nu Publications DANCE Publications GEANIE Publications ICE House and ICE II Publications (n,z) Publications Neutron Radiography Publications SPIDER Publications Target 2 Publications TPC Publications Links Publications/Media Neutron and Nuclear Science News Profiles Events at LANSCE LANL Research Libary

  2. The Office of Minority Economic Impact (MI) was established in...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Energy Conservation Policy Act (Public Law 95- 619), dated November 9, 1978. The ... Act and other applicable provisions of law, with any person, including minority ...

  3. Downregulation of miRNA-30c and miR-203a is associated with hepatitis C virus core protein-induced epithelial–mesenchymal transition in normal hepatocytes and hepatocellular carcinoma cells

    SciTech Connect

    Liu, Dongjing; Wu, Jilin; Liu, Meizhou; Yin, Hui; He, Jiantai; Zhang, Bo

    2015-09-04

    Hepatitis C virus (HCV) Core protein has been demonstrated to induce epithelial–mesenchymal transition (EMT) and is associated with cancer progression of hepatocellular carcinoma (HCC). However, how the Core protein regulates EMT is still unclear. In this study, HCV Core protein was overexpressed by an adenovirus. The protein levels of EMT markers were measured by Western blot. The xenograft animal model was established by inoculation of HepG2 cells. Results showed that ectopic expression of HCV core protein induced EMT in L02 hepatocytes and HepG2 tumor cells by upregulating vimentin, Sanl1, and Snal2 expression and downregulating E-cadherin expression. Moreover, Core protein downregulated miR-30c and miR-203a levels in L02 and HepG2 cells, but artificial expression of miR-30c and miR-203a reversed Core protein-induced EMT. Further analysis showed that ectopic expression of HCV core protein stimulated cell proliferation, inhibited apoptosis, and increased cell migration, whereas artificial expression of miR-30c and miR-203a significantly reversed the role of Core protein in these cell functions in L02 and HepG2 cells. In the HepG2 xenograft tumor models, artificial expression of miR-30c and miR-203a inhibited EMT and tumor growth. Moreover, L02 cells overexpressing Core protein can form tumors in nude mice. In HCC patients, HCV infection significantly shortened patients' survival time, and loss of miR-30c and miR-203 expression correlated with poor survival. In conclusion, HCV core protein downregulates miR-30c and miR-203a expression, which results in activation of EMT in normal hepatocytes and HCC tumor cells. The Core protein-activated-EMT is involved in the carcinogenesis and progression of HCC. Loss of miR-30c and miR-203a expression is a marker for the poor prognosis of HCC. - Highlights: • HCV core protein downregulates miR-30c and miR-203a expression. • Downregulation of miR-30c and miR-203a activates EMT. • Activated-EMT is involved in the

  4. miR-128 and its target genes in tumorigenesis and metastasis

    SciTech Connect

    Li, Molin, E-mail: molin_li@hotmail.com [Dalian Medical University, Dalian 116044 (China); Fu, Weiming [Center for Food Safety and Environmental Technology, Guangzhou Institute of Advanced Technology, Chinese Academy of Sciences, Guangzhou 511458 (China); Wo, Lulu; Shu, Xiaohong [Dalian Medical University, Dalian 116044 (China); Liu, Fang [The second affiliated hospital of Dalian Medical University, Dalian 116023 (China); Li, Chuangang, E-mail: li_chuangang@sina.com [The second affiliated hospital of Dalian Medical University, Dalian 116023 (China)

    2013-12-10

    MicroRNAs (miRNAs) are a class of endogenous, non-coding, 1824 nucleotide length single-strand RNAs that could modulate gene expression at post-transcriptional level. Previous studies have shown that miR-128 enriched in the brain plays an important role in the development of nervous system and the maintenance of normal physical functions. Aberrant expression of miR-128 has been detected in many types of human tumors and its validated target genes are involved in cancer-related biological processes such as cell proliferation, differentiation and apoptosis. In this review, we will summarize the roles of miR-128 and its target genes in tumorigenesis and metastasis. - Highlights: Aberrant expression of miR-128 can be observed in many kinds of malignant tumors. The molecular mechanisms regulating miR-128 expression are elucidated. Roles of miR-128 and its target genes in tumorigenesis and metastasis are summarized.

  5. miR-125b inhibits osteoblastic differentiation by down-regulation of cell proliferation

    SciTech Connect

    Mizuno, Yosuke; Yagi, Ken; Tokuzawa, Yoshimi; Kanesaki-Yatsuka, Yukiko; Suda, Tatsuo; Katagiri, Takenobu; Fukuda, Toru; Maruyama, Masayoshi; Okuda, Akihiko; Amemiya, Tomoyuki; Kondoh, Yasumitsu; Tashiro, Hideo; Okazaki, Yasushi

    2008-04-04

    Although various microRNAs regulate cell differentiation and proliferation, no miRNA has been reported so far to play an important role in the regulation of osteoblast differentiation. Here we describe the role of miR-125b in osteoblastic differentiation in mouse mesenchymal stem cells, ST2, by regulating cell proliferation. The expression of miR-125b was time-dependently increased in ST2 cells, and the increase in miR-125b expression was attenuated in osteoblastic-differentiated ST2 cells induced by BMP-4. The transfection of exogenous miR-125b inhibited proliferation of ST2 cells and caused inhibition of osteoblastic differentiation. In contrast, when the endogenous miR-125b was blocked by transfection of its antisense RNA molecule, alkaline phosphatase activity after BMP-4 treatment was elevated. These results strongly suggest that miR-125b is involved in osteoblastic differentiation through the regulation of cell proliferation.

  6. miR-15a/16 Enhances Radiation Sensitivity of Non-Small Cell Lung Cancer

    Office of Scientific and Technical Information (OSTI)

    Cells by Targeting the TLR1/NF-κB Signaling Pathway (Journal Article) | SciTech Connect miR-15a/16 Enhances Radiation Sensitivity of Non-Small Cell Lung Cancer Cells by Targeting the TLR1/NF-κB Signaling Pathway Citation Details In-Document Search Title: miR-15a/16 Enhances Radiation Sensitivity of Non-Small Cell Lung Cancer Cells by Targeting the TLR1/NF-κB Signaling Pathway Purpose: Many miRNAs have been identified as essential issues and core determining factors in tumor radiation.

  7. PNNL: Publication Details

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Details Sorry, we cannot locate that Publication. Please try the Publications Database for other PNNL Publications. Powered By ERICA, PNNL's publication metadatabase Publications Search Publications Science as Art Calendar Magazines and Newsletters Pacific Northwest Technology Today DOE Pulse Additional Resources PNNL Technical Library PNNL Photo Library PNNL Brochure Library Related Links PNNL Technical Library

  8. Public Affairs Department

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Public Affairs Department Public Affairs Communications Community Public Affairs Org Chart Education Creative Services ⇒ Navigate Section Public Affairs Communications Community Public Affairs Org Chart Education Creative Services The Public Affairs Department serves Berkeley Lab's scientific and educational missions by: Providing timely information and perspective about scientific discoveries to all of the Lab's internal and external audiences, ranging from potential scientific collaborators

  9. Overexpression of miR-206 suppresses glycolysis, proliferation and migration in breast cancer cells via PFKFB3 targeting

    SciTech Connect

    Ge, Xin; Lyu, Pengwei; Cao, Zhang; Li, Jingruo; Guo, Guangcheng; Xia, Wanjun; Gu, Yuanting

    2015-08-07

    miRNAs, sorting as non-coding RNAs, are differentially expressed in breast tumor and act as tumor promoters or suppressors. miR-206 could suppress the progression of breast cancer, the mechanism of which remains unclear. The study here was aimed to investigate the effect of miR-206 on human breast cancers. We found that miR-206 was down-regulated while one of its predicted targets, 6-Phosphofructo-2-kinase (PFKFB3) was up-regulated in human breast carcinomas. 17β-estradiol dose-dependently decreased miR-206 expression as well as enhanced PFKFB3 mRNA and protein expression in estrogen receptor α (ERα) positive breast cancer cells. Furthermore, we identified that miR-206 directly interacted with 3′-untranslated region (UTR) of PFKFB3 mRNA. miR-206 modulated PFKFB3 expression in MCF-7, T47D and SUM159 cells, which was influenced by 17β-estradiol depending on ERα expression. In addition, miR-206 overexpression impeded fructose-2,6-bisphosphate (F2,6BP) production, diminished lactate generation and reduced cell proliferation and migration in breast cancer cells. In conclusion, our study demonstrated that miR-206 regulated PFKFB3 expression in breast cancer cells, thereby stunting glycolysis, cell proliferation and migration. - Highlights: • miR-206 was down-regulated and PFKFB3 was up-regulated in human breast carcinomas. • 17β-estradiol regulated miR-206 and PFKFB3 expression in ERα+ cancer cells. • miR-206directly interacted with 3′-UTR of PFKFB3 mRNA. • miR-206 fructose-2,6-bisphosphate (F2,6BP) impeded production and lactate generation. • miR-206 reduced cell proliferation and migration in breast cancer cells.

  10. Tax Credits, Rebates & Savings | Department of Energy

    Energy.gov [DOE] (indexed site)

    Equipment, Vending Machine Controls, LED Lighting, Commercial Refrigeration Equipment Detroit Public Lighting Department- Commercial and Industrial Energy Wise Program The...

  11. AMENDMENT OF SOLICITATION/MODIFICATlON OF CONTRACT MI54 I See...

    National Nuclear Security Administration (NNSA)

    MI54 I See Block 16C I REQ. NO. Babcock & Wilcox Technical Services Pantex, LLC PO Box 30020 Amarillo, TX 79120 2. AMENDMENTIMODIFICATION NO. 1 3. EFFECTIVE DATE 1 4. ...

  12. File:USDA-CE-Production-GIFmaps-MI.pdf | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    MI.pdf Jump to: navigation, search File File history File usage Michigan Ethanol Plant Locations Size of this preview: 463 599 pixels. Other resolution: 464 600 pixels. Full...

  13. Simulations of neutron multiplicity measurements with MCNP-PoliMi.

    SciTech Connect

    Mattingly, John K.; Pozzi, Sara A.; Clarke, Shaun D.; Dennis, Ben D.; Miller, Eric C.

    2010-09-01

    The heightened focus on nuclear safeguards and accountability has increased the need to develop and verify simulation tools for modeling these applications. The ability to accurately simulate safeguards techniques, such as neutron multiplicity counting, aids in the design and development of future systems. This work focuses on validating the ability of the Monte Carlo code MCNPX-PoliMi to reproduce measured neutron multiplicity results for a highly multiplicative sample. The benchmark experiment for this validation consists of a 4.5-kg sphere of plutonium metal that was moderated by various thicknesses of polyethylene. The detector system was the nPod, which contains a bank of 15 3He detectors. Simulations of the experiments were compared to the actual measurements and several sources of potential bias in the simulation were evaluated. The analysis included the effects of detector dead time, source-detector distance, density, and adjustments made to the value of {nu}-bar in the data libraries. Based on this analysis it was observed that a 1.14% decrease in the evaluated value of {nu}-bar for 239Pu in the ENDF-VII library substantially improved the accuracy of the simulation.

  14. ARM - Publications Procedures

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    govPublicationsPublications Procedures Page Contents Types of ARM Publications Process for Publishing Planning Documents Science Reports Conference Documents Public Information Materials Recommendation for Journal Articles Proper Acknowledgments Publications Procedures Types of ARM Publications There are two main types of publications in ARM: (1) planning documents and (2) science reports. Planning documents include the ARM Program Plan, Science Plan, Locale Recommendation Plan, and Site

  15. Publications | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Publications Publications Photo courtesy of ©iStockphoto.com/Samohin Photo courtesy of ©iStockphoto.com/Samohin The EERE Publication and Product Library will allow you to find publications and products provided by the DOE's Office of Energy Efficiency and Renewable Energy specifically for our constituents. This database will allow you to do the following: Search for publications and products Download or view publications online Request a copy to be mailed to you. Visit the EERE Publication

  16. Climate Action Champions: Sault Ste. Marie Tribe of Chippewa Indians, MI |

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Department of Energy Sault Ste. Marie Tribe of Chippewa Indians, MI Climate Action Champions: Sault Ste. Marie Tribe of Chippewa Indians, MI The Sault Ste. Marie Tribe of Chippewa Indians is a 44,000-strong federally recognized Indian tribe that is an economic, social and cultural force in its community across the eastern Upper Peninsula counties of Chippewa, Luce, Mackinac, Schoolcraft, Alger, Delta and Marquette, with housing and tribal centers, casinos, and other enterprises that employ

  17. "Title","Creator/Author","Publication Date","OSTI Identifier...

    Office of Scientific and Technical Information (OSTI)

    Real-time sub-<mi>>ngstrom imaging of reversible and irreversible conformations in rhodium catalysts and graphene","Kisielowski, Christian;...

  18. Sandia Energy - PV Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications Home Stationary Power Energy Conversion Efficiency Solar Energy Photovoltaics PV Publications PV PublicationsTara Camacho-Lopez2016-01-05T23:50:37+00:00 Recent...

  19. Find Los Alamos Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Los Alamos Publications Find Los Alamos Publications Some of these resources are Lab-only and will require SSL Portal. Questions? 667-5809 Email Current Lab publications 1663 ...

  20. miR-196a targets netrin 4 and regulates cell proliferation and migration of cervical cancer cells

    SciTech Connect

    Zhang, Jie; Zheng, Fangxia; Yu, Gang; Yin, Yanhua; Lu, Qingyang

    2013-11-01

    Highlights: miR-196a was overexpressed in cervical cancer tissue compared to normal tissue. miR-196a expression elevated proliferation and migration of cervical cancer cells. miR-196a inhibited NTN4 expression by binding 3?-UTR region of NTN4 mRNA. NTN4 inversely correlated with miR-196a expression in cervical tissue and cell line. NTN4 expression was low in cervical cancer tissue compared to normal tissue. -- Abstract: Recent research has uncovered tumor-suppressive and oncogenic potential of miR-196a in various tumors. However, the expression and mechanism of its function in cervical cancer remains unclear. In this study, we assess relative expression of miR-196a in cervical premalignant lesions, cervical cancer tissues, and four cancer cell lines using quantitative real-time PCR. CaSki and HeLa cells were treated with miR-196a inhibitors, mimics, or pCDNA/miR-196a to investigate the role of miR-196a in cancer cell proliferation and migration. We demonstrated that miR-196a was overexpressed in cervical intraepithelial neoplasia 23 and cervical cancer tissue. Moreover, its expression contributes to the proliferation and migration of cervical cancer cells, whereas inhibiting its expression led to a reduction in proliferation and migration. Five candidate targets of miR-196a chosen by computational prediction and Cervical Cancer Gene Database search were measured for their mRNA in both miR-196a-overexpressing and -depleted cancer cells. Only netrin 4 (NTN4) expression displayed an inverse association with miR-196a. Fluorescent reporter assays revealed that miR-196a inhibited NTN4 expression by targeting one binding site in the 3?-untranslated region (3?-UTR) of NTN4 mRNA. Furthermore, qPCR and Western blot assays verified NTN4 expression was downregulated in cervical cancer tissues compared to normal controls, and in vivo mRNA level of NTN4 inversely correlated with miR-196a expression. In summary, our findings provide new insights about the functional role of

  1. Public Assembly Buildings

    Energy Information Administration (EIA) (indexed site)

    Most public assembly buildings were not large convention centers or entertainment arenas; about two-fifths fell into the smallest size category. About one-fifth of public...

  2. Public Outreach committee meeting

    Energy.gov [DOE]

    The ORSSAB Public Outreach Committee meeting is open to the public. The conference call information will be provided as the meeting approaches.

  3. NREL: Wind Research - Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications The NREL wind research program develops publications about its R&D projects, accomplishments, and goals in wind energy technologies. Here you will find links to some ...

  4. Commitment to Public Involvement

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Create a Sustainable Future Commitment to Public Involvement Commitment to Public Involvement LANL is committed to our neighbors August 1, 2013 Lab Director McMillan talks with...

  5. Small Business News, Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Small Business News, Publications Small Business News, Publications Setting new standards and small business initiatives within NNSA that will contribute to developing and...

  6. <mi>B> -meson decay constants from 2+1 -flavor lattice QCD with domain-wall light quarks and relativistic heavy quarks

    SciTech Connect

    Christ, N. H.; Flynn, J. M.; Izubuchi, T.; Kawanai, T.; Lehner, C.; Soni, A.; Van de Water, R. S.; Witzel, O.

    2015-03-01

    We calculate the mi>Bmi>-meson decay constants mi>fmi>mi>Bmi>, mi>fmi>mi>Bmi>mi>smi>, and their ratio in unquenched lattice QCD using domain-wall light quarks and relativistic mi>b> quarks. We use gauge-field ensembles generated by the RBC and UKQCD collaborations using the domain-wall fermion action and Iwasaki gauge action with three flavors of light dynamical quarks. We analyze data at two lattice spacings of mi>ami>0.11, 0.086 fm with unitary pion masses as light as mi>Mmi>mi>πmi>290mi>MeV>; this enables us to control the extrapolation to the physical light-quark masses and continuum. For the mi>b> quarks we use the anisotropic clover action with the relativistic heavy-quark interpretation, such that discretization errors from the heavy-quark action are of the same size as from the light-quark sector. We renormalize the

  7. miR-214 promotes the proliferation and invasion of osteosarcoma cells through direct suppression of LZTS1

    SciTech Connect

    Xu, Zhengyu; Wang, Tao

    2014-06-27

    Highlights: • miR-214 is upregulated in human OS tissues and inversely correlated with LZTS1 expression. • miR-214 directly targets LZTS1 by binding to its 3′-UTR. • miR-214 promotes OS cell proliferation, invasion and tumor growth. • Overexpression of LZTS1 reverses miR-214-induced proliferation and invasion of OS cells. - Abstract: Previous studies have shown that miR-214 functions either as an oncogene or a tumor suppressor in various human cancer types. The role of this microRNA in osteosarcoma (OS) is presently unclear. Here, we demonstrated that miR-214 is frequently upregulated in OS specimens, compared with noncancerous bone tissues. Bioinformatics analysis further revealed leucine zipper, putative tumor suppressor 1 (LZTS1) as a potential target of miR-214. Expression patterns of miR-214 were inversely correlated with those of LZTS1 mRNA and protein in OS tissues. Data from reporter assays showed that miR-214 directly binds to the 3′-untranslated region (3′-UTR) of LZTS1 mRNA and suppresses expression at both transcriptional and translational levels. In functional assays, miR-214 promoted OS cell proliferation, invasion and tumor growth in nude mice, which could be reversed by overexpression of LZTS1. Taken together, our data provide compelling evidence that miR-214 functions as an onco-miRNA in OS, and its oncogenic effects are mediated chiefly through downregulation of LZTS1.

  8. MiR-132 prohibits proliferation, invasion, migration, and metastasis in breast cancer by targeting HN1

    SciTech Connect

    Zhang, Zhan-Guo Chen, Wei-Xun Wu, Yan-Hui Liang, Hui-Fang Zhang, Bi-Xiang

    2014-11-07

    Highlights: • MiR-132 is down-regulated in breast cancer tissues and cell lines. • MiR-132 directly regulates HN1 by binding its 3′ UTR. • MiR-132 shows regulatory role in proliferation, invasion, migration and metastasis. • HN1 is involved in miR-132-mediated cell behavior. • Aberrant HN1 is associated with worse overall survival of breast cancer patients. - Abstract: Accumulating evidence indicates that miRNAs play critical roles in tumorigenesis and cancer progression. This study aims to investigate the role and the underlying mechanism of miR-132 in breast cancer. Here, we report that miR-132 is significantly down-regulated in breast cancer tissues and cancer cell lines. Additional study identifies HN1 as a novel direct target of miR-132. MiR-132 down-regulates HN1 expression by binding to the 3′ UTR of HN1 transcript, thereby, suppressing multiple oncogenic traits such as cancer cell proliferation, invasion, migration and metastasis in vivo and in vitro. Overexpression of HN1 restores miR-132-suppressed malignancy. Importantly, higher HN1 expression is significantly associated with worse overall survival of breast cancer patients. Taken together, our data demonstrate a critical role of miR-132 in prohibiting cell proliferation, invasion, migration and metastasis in breast cancer through direct suppression of HN1, supporting the potential utility of miR-132 as a novel therapeutic strategy against breast cancer.

  9. miR-421 induces cell proliferation and apoptosis resistance in human nasopharyngeal carcinoma via downregulation of FOXO4

    SciTech Connect

    Chen, Liang; Department of Otolaryngology, Guangzhou General Hospital of PLA Guangzhou Command, Guangzhou 510010 ; Tang, Yanping; Wang, Jian; Yan, Zhongjie; Xu, Ruxiang

    2013-06-14

    Highlights: •miR-421 is upregulated in nasopharyngeal carcinoma. •miR-421 induces cell proliferation and apoptosis resistance. •FOXO4 is a direct and functional target of miR-421. -- Abstract: microRNAs have been demonstrated to play important roles in cancer development and progression. Hence, identifying functional microRNAs and better understanding of the underlying molecular mechanisms would provide new clues for the development of targeted cancer therapies. Herein, we reported that a microRNA, miR-421 played an oncogenic role in nasopharyngeal carcinoma. Upregulation of miR-421 induced, whereas inhibition of miR-421 repressed cell proliferation and apoptosis resistance. Furthermore, we found that upregulation of miR-421 inhibited forkhead box protein O4 (FOXO4) signaling pathway following downregulation of p21, p27, Bim and FASL expression by directly targeting FOXO4 3′UTR. Additionally, we demonstrated that FOXO4 expression is critical for miR-421-induced cell growth and apoptosis resistance. Taken together, our findings not only suggest that miR-421 promotes nasopharyngeal carcinoma cell proliferation and anti-apoptosis, but also uncover a novel regulatory mechanism for inactivation of FOXO4 in nasopharyngeal carcinoma.

  10. Public Involvement Plan Public Involvement Plan

    Office of Environmental Management (EM)

    ... To be placed on the email distribution list for Public Involvement News, Cleanup Progress, and ... The documents listed below are available at the DOE Information Center and ...

  11. Jefferson Lab Public Affairs

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Web Design Photography Video Portfolio print version Public Affairs Links Home Journalists' Newsroom Media Photographic Archives What is Jefferson Lab? Community Outreach Public Affairs Children watch demonstrations of JLab equipment Take Our Children to Work Day Community Outreach JLab Event Calendar Schedule a Tour Speaker's Bureau Special Events K-12 Education Program Higher Education Programs JLab Public Newsroom JPIX Image Gallery Scientific Publications Database

  12. Roles of miRNAs in microcystin-LR-induced Sertoli cell toxicity

    SciTech Connect

    Zhou, Yuan; Wang, Hui; Wang, Cong; Qiu, Xuefeng; Benson, Mikael; Yin, Xiaoqin; Xiang, Zou; Li, Dongmei; and others

    2015-08-15

    Microcystin (MC)-LR, a cyclic heptapeptide, is a potent reproductive system toxin. To understand the molecular mechanisms of MC-induced reproductive system cytotoxicity, we evaluated global changes of miRNA and mRNA expression in mouse Sertoli cells following MC-LR treatment. Our results revealed that the exposure to MC-LR resulted in an altered miRNA expression profile that might be responsible for the modulation of mRNA expression. Bio-functional analysis indicated that the altered genes were involved in specific cellular processes, including cell death and proliferation. Target gene analysis suggested that junction injury in Sertoli cells exposed to MC-LR might be mediated by miRNAs through the regulation of the Sertoli cell-Sertoli cell pathway. Collectively, these findings may enhance our understanding on the modes of action of MC-LR on mouse Sertoli cells as well as the molecular mechanisms underlying the toxicity of MC-LR on the male reproductive system. - Highlights: • miRNAs were altered in Sertoli cells exposed to MC-LR. • Alerted genes were involved in different cell functions including the cell morphology. • MC-LR adversely affected Sertoli cell junction formation through the regulating miRNAs.

  13. NREL Publications Win Awards

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications Win Awards For more information contact: e:mail: Public Affairs Golden, Colo., April 17, 1998 — Six publications written at the U.S. Department of Energy's National Renewable Energy Laboratory earned international awards from the Society for Technical Communications (STC). The awards were part of STC's International Technical Publications Competition. Fifteen publications (including the six international winners) also won awards in STC's Rocky Mountain Chapter's annual

  14. Bioenergy Key Publications

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    KEY PUBLICATIONS BIOENERGY TECHNOLOGIES OFFICE Budget and Investment Resources PUBLICATION TITLE PUBLICATION DATE Bioenergy Technologies Office FY 2015 Budget-at-a-Glance March 2014 FY 2015 Congressional Budget Request (pp. 53-71) March 2014 American Recovery and Reinvestment Act: Bioenergy Technologies Office Investments June 2012 2013 Peer Review Report February 2014 Office Overview Resources PUBLICATION TITLE PUBLICATION DATE Bioenergy Technologies Office Walkthrough Presentation July 2014

  15. Publications | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Publications Publications This page contains a table that organizes the names and publication dates of the Bioenergy Technologies Office's key research and development portfolio documents, providing succinct descriptions of each document, and sorting them by category: fact sheets and summaries; design reports/case studies; and plans, roadmaps, and reports. Scroll to the Key Publications table below and read the descriptions to find the publication that best fits your needs. To access the full

  16. Ionizing Radiation–Inducible miR-27b Suppresses Leukemia Proliferation via Targeting Cyclin A2

    SciTech Connect

    Wang, Bo; Li, Dongping; Kovalchuk, Anna; Litvinov, Dmitry; Kovalchuk, Olga

    2014-09-01

    Purpose: Ionizing radiation is a common carcinogen that is important for the development of leukemia. However, the underlying epigenetic mechanisms remain largely unknown. The goal of the study was to explore microRNAome alterations induced by ionizing radiation (IR) in murine thymus, and to determine the role of IR-inducible microRNA (miRNA/miR) in the development of leukemia. Methods and Materials: We used the well-established C57BL/6 mouse model and miRNA microarray profiling to identify miRNAs that are differentially expressed in murine thymus in response to irradiation. TIB152 human leukemia cell line was used to determine the role of estrogen receptor–α (ERα) in miR-27b transcription. The biological effects of ectopic miR-27b on leukemogenesis were measured by western immunoblotting, cell viability, apoptosis, and cell cycle analyses. Results: Here, we have shown that IR triggers the differential expression of miR-27b in murine thymus tissue in a dose-, time- and sex-dependent manner. miR-27b was significantly down-regulated in leukemia cell lines CCL119 and TIB152. Interestingly, ERα was overexpressed in those 2 cell lines, and it was inversely correlated with miR-27b expression. Therefore, we used TIB152 as a model system to determine the role of ERα in miR-27b expression and the contribution of miR-27b to leukemogenesis. β-Estradiol caused a rapid and transient reduction in miR-27b expression reversed by either ERα-neutralizing antibody or ERK1/2 inhibitor. Ectopic expression of miR-27b remarkably suppressed TIB152 cell proliferation, at least in part, by inducing S-phase arrest. In addition, it attenuated the expression of cyclin A2, although it had no effect on the levels of PCNA, PPARγ, CDK2, p21, p27, p-p53, and cleaved caspase-3. Conclusion: Our data reveal that β-estradiol/ERα signaling may contribute to the down-regulation of miR-27b in acute leukemia cell lines through the ERK1/2 pathway, and that miR-27b may function as a tumor

  17. Curcumin inhibits oral squamous cell carcinoma SCC-9 cells proliferation by regulating miR-9 expression

    SciTech Connect

    Xiao, Can; Wang, Lili; Zhu, Lifang; Zhang, Chenping; Zhou, Jianhua

    2014-11-28

    Highlights: • miR-9 expression level was significantly decreased in OSCC tissues. • Curcumin significantly inhibited SCC-9 cells proliferation. • miR-9 mediates the inhibition of SCC-9 proliferation by curcumin. • Curcumin suppresses Wnt/β-catenin signaling in SCC-9 cells. • miR-9 mediates the suppression of Wnt/β-catenin signaling by curcumin. - Abstract: Curcumin, a phytochemical derived from the rhizome of Curcuma longa, has shown anticancer effects against a variety of tumors. In the present study, we investigated the effects of curcumin on the miR-9 expression in oral squamous cell carcinoma (OSCC) and explored the potential relationships between miR-9 and Wnt/β-catenin pathway in curcumin-mediated OSCC inhibition in vitro. As the results shown, the expression levels of miR-9 were significantly lower in clinical OSCC specimens than those in the adjacent non-tumor tissues. Furthermore, our results indicated that curcumin inhibited OSCC cells (SCC-9 cells) proliferation through up-regulating miR-9 expression, and suppressing Wnt/β-catenin signaling by increasing the expression levels of the GSK-3β, phosphorylated GSK-3β and β-catenin, and decreasing the cyclin D1 level. Additionally, the up-regulation of miR-9 by curcumin in SCC-9 cells was significantly inhibited by delivering anti-miR-9 but not control oligonucleotides. Downregulation of miR-9 by anti-miR-9 not only attenuated the growth-suppressive effects of curcumin on SCC-9 cells, but also re-activated Wnt/β-catenin signaling that was inhibited by curcumin. Therefore, our findings would provide a new insight into the use of curcumin against OSCC in future.

  18. miR-339-5p inhibits alcohol-induced brain inflammation through regulating NF-κB pathway

    SciTech Connect

    Zhang, Yu; Wei, Guangkuan; Di, Zhiyong; Zhao, Qingjie

    2014-09-26

    Graphical abstract: - Highlights: • Alcohol upregulates miR-339-5p expression. • miR-339-5p inhibits the NF-kB pathway. • miR-339-5p interacts with and blocks activity of IKK-beat and IKK-epsilon. • miR-339-5p modulates IL-1β, IL-6 and TNF-α. - Abstract: Alcohol-induced neuroinflammation is mediated by the innate immunesystem. Pro-inflammatory responses to alcohol are modulated by miRNAs. The miRNA miR-339-5p has previously been found to be upregulated in alcohol-induced neuroinflammation. However, little has been elucidated on the regulatory functions of this miRNA in alcohol-induced neuroinflammation. We investigated the function of miR-339-5p in alcohol exposed brain tissue and isolated microglial cells using ex vivo and in vitro techniques. Our results show that alcohol induces transcription of miR 339-5p, IL-6, IL-1β and TNF-α in mouse brain tissue and isolated microglial cells by activating NF-κB. Alcohol activation of NF-κB allows for nuclear translocation of the NF-κB subunit p65 and expression of pro-inflammatory mediators. miR-339-5p inhibited expression of these pro-inflammatory factors through the NF-κB pathway by abolishing IKK-β and IKK-ε activity.

  19. miR-208-3p promotes hepatocellular carcinoma cell proliferation and invasion through regulating ARID2 expression

    SciTech Connect

    Yu, Peng; Wu, Dingguo; You, Yu; Sun, Jing; Lu, Lele; Tan, Jiaxing; Bie, Ping

    2015-08-15

    MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at post-transcriptional level. miRNA dysregulation plays a causal role in cancer progression. In this study, miR-208-3p was highly expressed and directly repressed ARID2 expression. As a result, ARID2 expression in hepatocellular carcinoma (HCC) was decreased. In vitro, miR-208-3p down-regulation and ARID2 over-expression elicited similar inhibitory effects on HCC cell proliferation and invasion. In vivo test results revealed that miR-208-3p down-regulation inhibited HCC tumorigenesis in Hep3B cells. Moreover, ARID2 was possibly a downstream element of transforming growth factor beta1 (TGFβ1)/miR-208-3p/ARID2 regulatory pathway. These findings suggested that miR-208-3p up-regulation is associated with HCC cell progression and may provide a new target for liver cancer treatment. - Highlights: • miR-208-3p was highly expressed and directly repressed the expression of ARID2 in HCC. • miR-208-3p contributed to HCC cell progression both in vitro and in vivo. • Over-expression of ARID2 inhibited the HCC cell proliferation and invasion. • Restoration of ARID2 partly reversed the the effect of miR-208-3p down-regulation on HCC cells. • Newly regulatory pathway: miR-208-3p mediated the repression of ARID2 by TGFβ1 in HCC cells.

  20. MicroRNAs expression in ox-LDL treated HUVECs: MiR-365 modulates apoptosis and Bcl-2 expression

    SciTech Connect

    Qin, Bing; Xiao, Bo; Liang, Desheng; Xia, Jian; Li, Ye; Yang, Huan

    2011-06-24

    Highlights: {yields} We evaluated the role of miRNAs in ox-LDL induced apoptosis in ECs. {yields} We found 4 up-regulated and 11 down-regulated miRNAs in apoptotic ECs. {yields} Target genes of the dysregulated miRNAs regulate ECs apoptosis and atherosclerosis. {yields} MiR-365 promotes ECs apoptosis via suppressing Bcl-2 expression. {yields} MiR-365 inhibitor alleviates ECs apoptosis induced by ox-LDL. -- Abstract: Endothelial cells (ECs) apoptosis induced by oxidized low-density lipoprotein (ox-LDL) is thought to play a critical role in atherosclerosis. MicroRNAs (miRNAs) are a class of noncoding RNAs that posttranscriptionally regulate the expression of genes involved in diverse cell functions, including differentiation, growth, proliferation, and apoptosis. However, whether miRNAs are associated with ox-LDL induced apoptosis and their effect on ECs is still unknown. Therefore, this study evaluated potential miRNAs and their involvement in ECs apoptosis in response to ox-LDL stimulation. Microarray and qRT-PCR analysis performed on human umbilical vein endothelial cells (HUVECs) exposed to ox-LDL identified 15 differentially expressed (4 up- and 11 down-regulated) miRNAs. Web-based query tools were utilized to predict the target genes of the differentially expressed miRNAs, and the potential target genes were classified into different function categories with the gene ontology (GO) term and KEGG pathway annotation. In particular, bioinformatics analysis suggested that anti-apoptotic protein B-cell CLL/lymphoma 2 (Bcl-2) is a target gene of miR-365, an apoptomir up-regulated by ox-LDL stimulation in HUVECs. We further showed that transfection of miR-365 inhibitor partly restored Bcl-2 expression at both mRNA and protein levels, leading to a reduction of ox-LDL-mediated apoptosis in HUVECs. Taken together, our findings indicate that miRNAs participate in ox-LDL-mediated apoptosis in HUVECs. MiR-365 potentiates ox-LDL-induced ECs apoptosis by regulating the

  1. Public Reading Room

    Office of Legacy Management (LM)

    By law, DOE must and will make a Public Reading Room available through site closure. Post-Closure: LM will maintain a Public Reading Room in accordance with EPA and Ohio EPA ...

  2. NREL: Energy Storage - Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications Explore NREL's most recent and popular publications. A complete collection of NREL's transportation and energy storage publications can be found in the NREL Publications Database. Papers, Presentations, and Posters Fact sheets Papers, Presentations, and Posters 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996 | 1995 | 1994 2016 NREL Multiphysics Modeling Tools and ISC Device for Designing

  3. Classification Documents and Publications

    Energy.gov [DOE]

    Certain documents and publications created or issued by the Office of Classification are available from this page.

  4. Publications & Reports

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    User Surveys HPC Requirements for Science HPC Workshop Reports NERSC Staff Publications & Presentations Journal Cover Stories Galleries facebook icon Facebook google plus icon Google+ twitter icon Twitter Home » News & Publications » Publications & Reports Publications & Reports » Download the NERSC Strategic Plan (PDF | 3.2 MB) NERSC Annual Reports NERSC's annual reports highlight the scientific accomplishments of its users and innovations of its staff. Read More » Science

  5. Public Forum: Laboratory trails

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Public Comment Opportunities Public Comment Opportunities Below are links to DOE NEPA projects with open comment periods, including comment periods on the proposed scope of planned NEPA documents and on draft NEPA documents (e.g., draft environmental assessments and draft environmental impacts statements). EIS-0530: Nationwide Public Safety Broadband Network Programmatic Environmental Impact Statement for the Southern United States Public Comment Period Ends: December 13, 2016 The First

  6. Publications | Argonne National Laboratory

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications The public CNM Publications database includes journal articles and peer-reviewed conference proceedings that result form research at the CNM. We are also interested in learning about patents or other output in the public domain. Please contact cnm_useroffice@anl.gov with any such information. ACKNOWLEDGING CNM Crediting the CNM by using the proper acknowledgment statement, including CNM staff as co-authors when appropriate, and informing us of the existence of such information is

  7. LANSCE | Lujan Center | Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications Lujan Publications: 2009 - 2012 2012 | 2011 | 2010 | 2009 Publication acknowledgement Lujan Center monitors the number of papers published as a result of the use of our facilities. The Lujan Center's sponsoring agencies requires users to publish results from their non proprietary research. Authorship of publications based on research from user facilities should reflect the normal considerations of recognizing collaborations. Proprietary users are not required to publish. Users are

  8. EIA publications directory, 1992

    SciTech Connect

    Not Available

    1993-06-24

    This directory contains abstracts and ordering information for EIA publications. The abstracts are arranged by broad subject category such as coal, petroleum, natural gas, and electric power. A comprehensive subject index, a title index, and a report number index are included. Each entry gives the title, report number, publication frequency, date, number of pages, and ordering information. Publication began with the 1979 edition.

  9. NREL: Transportation Research - Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications NREL researchers document their findings in technical reports, conference papers, journal articles, and fact sheets. Visit the following online resources to find publications about sustainable transportation research, development, and deployment. Capabilities Overviews These recent publications highlight some of our capabilities, facilities, and projects: Image of fact sheet cover. Sustainable Transportation This overview fact sheet describes NREL's sustainable transportation

  10. MiRNA-125a-5p inhibits glioblastoma cell proliferation and promotes cell differentiation by targeting TAZ

    SciTech Connect

    Yuan, Jian; Xiao, Gelei; Peng, Gang; Liu, Dingyang; Wang, Zeyou; Liao, Yiwei; Liu, Qing; Wu, Minghua; Yuan, Xianrui

    2015-02-06

    Highlights: • Expression of miR-125a-5p is inversely correlated with that of TAZ in glioma cells. • MiR-125a-5p represses TAZ expression in glioma cells. • MiR-125a-5p directly targets the 3′ UTR of TAZ mRNA and promotes its degradation. • MiR-125a-5p represses CTGF and survivin via TAZ, and inhibits glioma cell growth. • MiR-125a-5p inhibits the stem cell features of HFU-251 MG cells. - Abstract: Glioblastoma (GBM) is the most lethal brain tumor due to the resistance to conventional therapies, such as radiotherapy and chemotherapy. TAZ, an important mediator of the Hippo pathway, was found to be up-regulated in diverse cancers, including in GBM, and plays important roles in tumor initiation and progression. However, little is known about the regulation of TAZ expression in tumors. In this study, we found that miR-125a-5p is an important regulator of TAZ in glioma cells by directly targeting the TAZ 3′ UTR. MiR-125a-5p levels are inversely correlated with that of TAZ in normal astrocytes and a panel of glioma cell lines. MiR-125a-5p represses the expression of TAZ target genes, including CTGF and survivin, and inhibits cell proliferation and induces the differentiation of GBM cells; whereas over-expression of TAZ rescues the effects of miR-125a-5p. This study revealed a mechanism for TAZ deregulation in glioma cells, and also demonstrated a tumor suppressor role of miR-125a-5p in glioblastoma cells.

  11. The NuMI proton beam at Fermilab successes and challenges

    SciTech Connect

    Childress, S.; /Fermilab

    2008-11-01

    The NuMI beam at Fermilab has delivered over 5 x 10{sup 20} 120 GeV protons to the neutrino production target since the start for MINOS [1] neutrino oscillation experiment operation in 2005. We report on proton beam commissioning and operation status, including successes and challenges with this beam.

  12. DOE Zero Energy Ready Home Case Study: Cobblestone Homes, Midland, MI

    Office of Energy Efficiency and Renewable Energy (EERE)

    Case study of a DOE Zero Energy Ready home in Midland, MI, that scored HERS 49 without PV or HERS 44 with 1.4 kW of PV. The custom home served as a prototype and energy efficiency demonstration...

  13. MiR-18a regulates the proliferation, migration and invasion of human glioblastoma cell by targeting neogenin

    SciTech Connect

    Song, Yichen; Wang, Ping; Zhao, Wei; Yao, Yilong; Liu, Xiaobai; Ma, Jun; Xue, Yixue; Liu, Yunhui

    2014-05-15

    MiR-17-92 cluster has recently been reported as an oncogene in some tumors. However, the association of miR-18a, an important member of this cluster, with glioblastoma remains unknown. Therefore, this study aims to investigate the expression of miR-18a in glioblastoma and its role in biological behavior of U87 and U251 human glioblastoma cell lines. Quantitative RT-PCR results showed that miR-18a was highly expressed in glioblastoma tissues and U87 and U251 cell lines compared with that in human brain tissues and primary normal human astrocytes, and the expression levels were increased along with the rising pathological grades of glioblastoma. Neogenin was identified as the target gene of miR-18a by dual-luciferase reporter assays. RT-PCR and western blot results showed that its expression levels were decreased along with the rising pathological grades of glioblastoma. Inhibition of miR-18a expression was established by transfecting exogenous miR-18a inhibitor into U87 and U251 cells, and its effects on the biological behavior of glioblastoma cells were studied using CCK-8 assay, transwell assay and flow cytometry. Inhibition of miR-18a expression in U87 and U251 cells significantly up-regulated neogenin, and dramatically suppressed the abilities of cell proliferation, migration and invasion, induced cell cycle arrest and promoted cellular apoptosis. Collectively, these results suggest that miR-18a may regulate biological behavior of human glioblastoma cells by targeting neogenin, and miR-18a can serve as a potential target in the treatment of glioblastoma. - Highlights: • MiR-18a was highly expressed in glioblastoma tissues and U87 and U251 cell lines. • Neogenin was identified as the target gene of miR-18a. • Neogenin expressions were decreased along with the rising pathological grades of glioblastoma. • Inhibition of miR-18a suppressed biological behavior of glioma cells by up-regulating neogenin.

  14. http://www.ars.usda.gov/research/publications/Publications.htm...

    National Nuclear Security Administration (NNSA)

    - Ed Wagner, Larry Tatarko, John Publications Publications Related National Programs Air Quality (203) Soil Resource Management (202) Page 1 of 2 ARS | Publication request:...

  15. miR-7 and miR-218 epigenetically control tumor suppressor genes RASSF1A and Claudin-6 by targeting HoxB3 in breast cancer

    SciTech Connect

    Li, Qiaoyan; Zhu, Fufan; Chen, Puxiang

    2012-07-20

    Highlights: Black-Right-Pointing-Pointer Both miR-7 and miR-218 down-regulates HoxB3 expression by targeting the 3 Prime -UTR of HoxB3 mRNA. Black-Right-Pointing-Pointer A reverse correlation between the levels of endogenous miR-7, miR218 and HoxB3 expression. Black-Right-Pointing-Pointer Epigenetic changes involve in the reactivation of HoxB3. Black-Right-Pointing-Pointer Both miRNAs inhibits the cell cycle and clone formation of breast cancer cells. -- Abstract: Many microRNAs have been implicated as key regulators of cellular growth and differentiation and have been found to dysregulate proliferation in human tumors, including breast cancer. Cancer-linked microRNAs also alter the epigenetic landscape by way of DNA methylation and post-translational modifications of histones. Aberrations in Hox gene expression are important for oncogene or tumor suppressor during abnormal development and malignancy. Although recent studies suggest that HoxB3 is critical in breast cancer, the putative role(s) of microRNAs impinging on HoxB3 is not yet fully understood. In this study, we found that the expression levels of miR-7 and miR-218 were strongly and reversely associated with HoxB3 expression. Stable overexpression of miR-7 and miR-218 was accompanied by reactivation of tumor suppressor genes including RASSF1A and Claudin-6 by means of epigenetic switches in DNA methylation and histone modification, giving rise to inhibition of the cell cycle and clone formation of breast cancer cells. The current study provides a novel link between overexpression of collinear Hox genes and multiple microRNAs in human breast malignancy.

  16. Detroit Edison Co | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Yes Activity Buying Transmission Yes Activity Distribution Yes Activity Wholesale Marketing Yes Activity Retail Marketing Yes Activity Bundled Services Yes Alt Fuel Vehicle Yes...

  17. SEP Case Study Webinar: Detroit Diesel

    Office of Energy Efficiency and Renewable Energy (EERE)

    This Measurement and Verification Case Study webinar is the fourth in its series highlighting U.S. manufacturing facilities that have achieved Superior Energy Performance (SEP) certification. These...

  18. Clean Cities: Detroit Area Clean Cities coalition

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Corporation; the Olkonorei Integrated Pastoralist Survival Program in Tanzania, Africa; and as an instructor at the Japanese Ministry of Education in Imadate, Japan. He has...

  19. DOE Emergency Public Affairs Plan

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Headquarters Office of Public Affairs Emergency Public Affairs Plan The DOE HQ Office of Public Affairs Emergency Public Affairs Plan has been approved for implementation by: __________________________________________________________ Dan Leistikow, Director, HQ Office of Public Affairs Date: ______________ __________________________________________________________ Joseph Krol, Director, HQ Office of Emergency Management Date: ______________ DOE Office of Public Affairs Emergency Public Affairs

  20. Loss of expression of miR-335 is implicated in hepatic stellate cell migration and activation

    SciTech Connect

    Chen, Chao; Wu, Chao-Qun; Zhang, Zong-Qi; Yao, Ding-Kang; Zhu, Liang

    2011-07-15

    Activation and migration of resident stellate cells (HSCs) within the hepatic space of Disse play an important role in hepatic fibrosis, which accounts for the increased numbers of activated HSCs in areas of inflammation during hepatic fibrosis. Currently, microRNAs have been found to play essential roles in HSC differentiation, proliferation, apoptosis, fat accumulation and collagen production. However, little is known about microRNA mediated HSC activation and migration. In this study, the miRNA expression profiles of quiescent HSCs, partially activated HSCs and fully activated HSCs were compared in pairs. Gene ontology (GO) and GO-Map network analysis indicated that the activation of HSCs was regulated by microRNAs. Among them miR-335 was confirmed to be significantly reduced during HSC activation by qRT-PCR, and restoring expression of miR-335 inhibited HSC migration and reduced {alpha}-SMA and collagen type I. Previous study revealed that tenascin-C (TNC), an extracellular matrix glycoprotein involved in cell migration, might be a target of miR-335. Therefore, we further studied the TNC expression in miR-335 over-expressed HSCs. Our data showed that exogenous TNC could enhance HSC migration in vitro and miR-335 restoration resulted in a significant inhibition of TNC expression. These results demonstrated that miR-335 restoration inhibited HSC migration, at least in part, via downregulating the TNC expression.

  1. EA-1690: A123 Systems, Inc., Automotive-Class Lithium-Ion Battery

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Production Facilities near Detroit, MI | Department of Energy 0: A123 Systems, Inc., Automotive-Class Lithium-Ion Battery Production Facilities near Detroit, MI EA-1690: A123 Systems, Inc., Automotive-Class Lithium-Ion Battery Production Facilities near Detroit, MI April 1, 2010 EA-1690: Final Environmental Assessment For a Loan and Grant to A123 Systems, Inc., for Vertically Integrated Mass Production of Automotive-Class Lithium-Ion Batteries April 20, 2010 EA-1690: Finding of No

  2. EA-171-B_Powerex.pdf

    Energy Saver

    Production Facilities near Detroit, MI | Department of Energy 0: A123 Systems, Inc., Automotive-Class Lithium-Ion Battery Production Facilities near Detroit, MI EA-1690: A123 Systems, Inc., Automotive-Class Lithium-Ion Battery Production Facilities near Detroit, MI April 1, 2010 EA-1690: Final Environmental Assessment For a Loan and Grant to A123 Systems, Inc., for Vertically Integrated Mass Production of Automotive-Class Lithium-Ion Batteries April 20, 2010 EA-1690: Finding of No

  3. PSMB4 promotes multiple myeloma cell growth by activating NF-κB-miR-21 signaling

    SciTech Connect

    Zheng, Peihao; Guo, Honggang; Li, Guangchao; Han, Siqi; Luo, Fei; Liu, Yi

    2015-03-06

    Proteasomal subunit PSMB4, was recently identified as potential cancer driver genes in several tumors. However, the regulatory mechanism of PSMB4 on carcinogenesis process remains unclear. In this study, we investigated the expression and roles of PSMB4 in multiple myeloma (MM). We found a significant up-regulation of PSMB4 in MM plasma and cell lines. Ectopic overexpression of PSMB4 promoted cell growth and colony forming ability of MM cells, whereas inhibition of PSMB4 led to a decrease of such events. Furthermore, our results demonstrated the up-regulation of miR-21 and a positive correlation between the levels of miR-21 and PSMB4 in MM. Re-expression of miR-21 markedly rescued PSMB4 knockdown-mediated suppression of cell proliferation and clone-formation. Additionally, while enforced expression of PSMB4 profoundly increased NF-κB activity and the level of miR-21, PSMB4 knockdown or NF-κB inhibition suppressed miR-21 expression in MM cells. Taken together, our results demonstrated that PSMB4 regulated MM cell growth in part by activating NF-κB-miR-21 signaling, which may represent promising targets for novel specific therapies. - Highlights: • First reported upregulation of PSMB4 in MM plasma and cell lines. • PSMB4 promoted MM cell growth and colony forming ability. • Further found miR-21 was up-regulated by PSMB4 in MM plasma and cell lines. • PSMB4-induced miR-21 expression was modulated by NF-κB. • PSMB4-NF-κB-miR-21 axis may be potential therapeutic targets of MM.

  4. Consent Order public meeting

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Consent Order public meeting Consent Order public meeting WHEN: Apr 28, 2016 5:00 PM - 7:00 PM WHERE: Los Alamos County Council Chambers CATEGORY: Community TYPE: Meeting INTERNAL: Calendar Login Event Description On March 1, 2005, NMED, the Department of Energy (DOE) and the Regents of the University of California entered into the 2005 Consent Order that prescribed fence-to-fence cleanup requirements for the Laboratory. The public comment period on the Consent Order closes May 16, 2016

  5. Mound publications for 1991

    SciTech Connect

    Nowka, Stephen L.

    1992-05-01

    This document is a compilation of all Mound formal technical publications and oral presentations for calendar year 1991. It is intended to serve as an aid to personnel in obtaining or referring to specific publications by giving the proper complete reference for each information item published during the year. Some items, such as proceedings publications, may have issue dates or periods of coverage prior to 1991; however, they were formally published during 1991.

  6. Publications | The Ames Laboratory

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Inquiries Publications Below is a bibliography of publications that cite the MPC (or more generically, the Ames Laboratory) as the source for the pure metals, alloys, or single crystals used in said publication. This list is non-exhaustive. If you have a paper in which such a citation is made please send us the citation. Expectations for citation or acknowledgement: MPC operations are funded by the US DOE Office of Basic Energy Sciences. Acknowledgement of the use MPC facilities/services is

  7. NREL: Geothermal Technologies - Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications NREL's geothermal team develops publications, including technical reports and conference papers, about geothermal resource assessments, market and policy analysis, and geothermal research and development (R&D) activities. In addition to the selected documents available below, you can find resources on the U.S. Department of Energy (DOE) Geothermal Technologies Office website or search the NREL Publications Database. Learn more about how research at NREL is accelerating

  8. WIPP - Public Reading Facilities

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Public Reading Facilities/Electronic Reading Facilities The Freedom of Information Act (FOIA) and Electronic FOIA (E-FOIA) require that various specific types of records, as well as various other records, be maintained in public reading facilities. Before you submit a FOIA request, we recommend you contact or visit the appropriate public reading facility to determine if the records you are seeking have already been released. The U.S. Department of Energy (DOE), as well as other related DOE

  9. Jefferson Lab Public Affairs

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Electronic Media print version Public Affairs Links Home Journalists' Newsroom Media Photographic Archives What is Jefferson Lab? Community Outreach Public Affairs Director's Office - Media The Public Affairs Office is prepared to aid media representatives in preparing for JLab stories and photo sessions. We can also help reporters find expert sources for science and technology-based stories. Media kits, provided upon request, offer a wealth of JLab information including fact sheets, photos,

  10. Electronic Public Reading Room

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Guides Video Tutorials Mobile Resources Alerts Bibliographic Management Scholarly Communication & Open Access Copyright Open Access ORCID Primo About the Library » Electronic Public Reading Room Electronic Public Reading Room Find Los Alamos environmental reports on air and water quality, biological and cultural resources, environmental monitoring, and more online using the Electronic Reading Room (EPRR). The Electronic Public Reading Room (EPRR) contains Los Alamos documents required for

  11. Water Power Program: Publications

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    2014 Hydropower Market Report Details Bookmark & Share View Related Welcome to the Water Power Program Publication and Product Library. This library will allow you to find...

  12. Publications | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Lighting (SSL) program produces a comprehensive portfolio of publications, ranging from overviews of the program's research activities to information on numerous SSL issues and ...

  13. Bioenergy Technologies Office: Publications

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Advanced Search Browse by Topic Mail Requests Help Key Publications Newsletter Biomass Basics Multimedia Webinars Databases Analytical Tools Glossary Student & Educator Resources...

  14. Wind Program: Publications

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Resources Publications Advanced Search Browse by Topic Mail Requests Help Energy Basics Wind Energy FAQs Small Wind Systems FAQs Multimedia Related Links Feature featured...

  15. Geothermal Outreach Publications

    Energy.gov [DOE]

    Here you'll find the U.S. Department of Energy's (DOE) most recent outreach publications about geothermal technologies, research, and development.

  16. Sandia National Laboratories: publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    plasticity in BCC transition metals", accepted for publication in Modeling and Simulation in Materials Science and Engineering, April 2013. J. Carroll, W. Z. Abuzaid, J....

  17. Public Outreach Fact Sheet

    Office of Energy Efficiency and Renewable Energy (EERE)

    This fact sheet provides information about the U.S. Department of Energy Office of Legacy Management public outreach principles and approaches.

  18. Other Geothermal Energy Publications

    Energy.gov [DOE]

    Here you'll find links to other organization's publications — including technical reports, newsletters, brochures, and more — about geothermal energy.

  19. Archived Publications and Documents

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Archived Publications and Documents Print ALS 20-Year Roadmap, 2003 Presentations made to the BESAC subcommittee on the 20-Year BES Facilities Roadmap, with references and relevant...

  20. Emergency Public Information

    Directives, Delegations, and Other Requirements [Office of Management (MA)]

    1997-08-21

    This volume defines elements of providing information to the public during and following emergencies. Canceled by DOE G 151.1-4.

  1. National Laboratory Geothermal Publications

    Energy.gov [DOE]

    You can find publications, including technical papers and reports, about geothermal technologies, research, and development at the following U.S. Department of Energy national laboratories.

  2. NREL: Energy Analysis - Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications that Illuminate System Operation with High-Penetration Renewables Beyond Renewable Portfolio Standards: An Assessment of Regional Supply and Demand Conditions ...

  3. Sandia Energy Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publication in Ocean Engineering http:energy.sandia.govpublication-in-ocean-engineering http:energy.sandia.govpublication-in-ocean-engineeringcomments Tue, 22 Dec 2015...

  4. Jefferson Lab Public Affairs

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Electronic Media print version Public Affairs Links Home Journalists' Newsroom Media Photographic Archives What is Jefferson Lab? Community Outreach Jefferson Lab Graphic Identity ...

  5. NEPA-Related Public Involvement

    Energy.gov [DOE]

    The Loan Programs Office’s NEPA-related hearings, public meetings, and public notices (e.g. public scoping meeting, public hearing, notice of proposed floodplain or wetland action) are presented...

  6. Effective Public Participation

    Energy.gov [DOE]

    This paper provides guidance to Department of Energy personnel for involving the public effectively and meaningfully in DOE processes conducted under the National Environmental Policy Act. It was prepared in furtherance of the Secretary of Energy's 1994 Public Participation Policy and Policy on the National Environmental Policy Act.

  7. EIA Publications Directory 1993

    SciTech Connect

    Not Available

    1994-07-18

    This directory contains abstracts and ordering information for EIA publications released in the above time period. The abstracts are arranged by broad subject category such as coal, petroleum, natural gas, and electric power. A comprehensive subject index, a title index, and a report number index are included. Each entry gives the title, report number, publication frequency, date, number of pages, and ordering information.

  8. FWP Scientific Publications

    Energy.gov [DOE]

    Scientific publications either directly studying former workers in the context of the screening program or recruiting former workers in the program as research participants for scientific studies funded by the National Institutes of Health or other research funding sources are summarized below according to publication date.

  9. RLIP76-dependent suppression of PI3K/AKT/Bcl-2 pathway by miR...

    Office of Scientific and Technical Information (OSTI)

    in prostate cancer Citation Details In-Document Search Title: RLIP76-dependent suppression of PI3KAKTBcl-2 pathway by miR-101 induces apoptosis in prostate cancer MicroRNA-101 ...

  10. Aryl hydrocarbon receptor-dependent regulation of miR-196a expression controls lung fibroblast apoptosis but not proliferation

    SciTech Connect

    Hecht, Emelia; Zago, Michela; Sarill, Miles; Rico de Souza, Angela; Gomez, Alvin; Matthews, Jason; Hamid, Qutayba; Eidelman, David H.; Baglole, Carolyn J.

    2014-11-01

    The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor implicated in the regulation of apoptosis and proliferation. Although activation of the AhR by xenobiotics such as dioxin inhibits the cell cycle and control apoptosis, paradoxically, AhR expression also promotes cell proliferation and survival independent of exogenous ligands. The microRNA (miRNA) miR-196a has also emerged as a regulator of proliferation and apoptosis but a relationship between the AhR and miR-196a is not known. Therefore, we hypothesized that AhR-dependent regulation of endogenous miR-196a expression would promote cell survival and proliferation. Utilizing lung fibroblasts from AhR deficient (AhR{sup −/−}) and wild-type (AhR{sup +/+}) mice, we show that there is ligand-independent regulation of miRNA, including low miR-196a in AhR{sup −/−} cells. Validation by qRT-PCR revealed a significant decrease in basal expression of miR-196a in AhR{sup −/−} compared to AhR{sup +/+} cells. Exposure to AhR agonists benzo[a]pyrene (B[a]P) and FICZ as well as AhR antagonist CH-223191 decreased miR-196a expression in AhR{sup +/+} fibroblasts concomitant with decreased AhR protein levels. There was increased proliferation only in AhR{sup +/+} lung fibroblasts in response to serum, corresponding to a decrease in p27{sup KIP1} protein, a cyclin-dependent kinase inhibitor. Increasing the cellular levels of miR-196a had no effect on proliferation or expression of p27{sup KIP1} in AhR{sup −/−} fibroblasts but attenuated cigarette smoke-induced apoptosis. This study provides the first evidence that AhR expression is essential for the physiological regulation of cellular miRNA levels- including miR-196a. Future experiments designed to elucidate the functional relationship between the AhR and miR-196a may delineate additional novel ligand-independent roles for the AhR. - Highlights: • The AhR controls proliferation and apoptosis in lung cells. • The AhR regulates the

  11. Material Activation Benchmark Experiments at the NuMI Hadron Absorber Hall in Fermilab

    SciTech Connect

    Matsumura, H.; Matsuda, N.; Kasugai, Y.; Toyoda, A.; Yashima, H.; Sekimoto, S.; Iwase, H.; Oishi, K.; Sakamoto, Y.; Nakashima, H.; Leveling, A.; Boehnlein, D.; Lauten, G.; Mokhov, N.; Vaziri, K.

    2014-06-15

    In our previous study, double and mirror symmetric activation peaks found for Al and Au arranged spatially on the back of the Hadron absorber of the NuMI beamline in Fermilab were considerably higher than those expected purely from muon-induced reactions. From material activation bench-mark experiments, we conclude that this activation is due to hadrons with energy greater than 3 GeV that had passed downstream through small gaps in the hadron absorber.

  12. Measurement of Pi-K Ratios from the NuMI Target

    SciTech Connect

    Seun, Sin Man

    2007-07-01

    Interactions of protons (p) with the NuMI (Neutrinos at the Main Injector) target are used to create the neutrino beam for the MINOS (Main Injector Neutrino Oscillation Search) Experiment. Using the MIPP (Main Injector Particle Production) experimental apparatus, the production of charged pions and kaons in p+NuMI interactions is studied. The data come from a sample of 2 x 106 events obtained by MIPP using the 120 GeV/c proton beam from the Main Injector at Fermi National Accelerator Laboratory in Illinois, USA. Pions and kaons are identified by measurement in a Ring Imaging Cherenkov detector. Presented are measurements of π-+, K-/K+, π+/K+ and π-/K- production ratios in the momentum range pT < 2 GeV/c transversely and 20 GeV/c < pz < 90 GeV/c longitudinally. Also provided are detailed comparisons of the MIPP NuMI data with the MIPP Thin Carbon data, the MIPP Monte Carlo simulation and the current MINOS models in the relevant momentum ranges.

  13. miR-21 modulates tumor outgrowth induced by human adipose tissue-derived mesenchymal stem cells in vivo

    SciTech Connect

    Shin, Keun Koo; Lee, Ae Lim; Kim, Jee Young; Medical Research Center for Ischemic Tissue Engineering, Pusan National University, Yangsan, Gyeongnam 626-870; BK21 Medical Science Education Center, School of Medicine, Pusan National University, Yangsan, Gyeongnam 626-870 ; Lee, Sun Young; Medical Research Center for Ischemic Tissue Engineering, Pusan National University, Yangsan, Gyeongnam 626-870 ; Bae, Yong Chan; Jung, Jin Sup

    2012-06-15

    Highlights: Black-Right-Pointing-Pointer miR-21 modulates hADSC-induced increase of tumor growth. Black-Right-Pointing-Pointer The action is mostly mediated by the modulation of TGF-{beta} signaling. Black-Right-Pointing-Pointer Inhibition of miR-21 enhances the blood flow recovery in hindlimb ischemia. -- Abstract: Mesenchymal stem cells (MSCs) have generated a great deal of interest in clinical situations, due principally to their potential use in regenerative medicine and tissue engineering applications. However, the therapeutic application of MSCs remains limited, unless the favorable effects of MSCs on tumor growth in vivo, and the long-term safety of the clinical applications of MSCs, can be more thoroughly understood. In this study, we determined whether microRNAs can modulate MSC-induced tumor outgrowth in BALB/c nude mice. Overexpression of miR-21 in human adipose-derived stem cells (hADSCs) inhibited hADSC-induced tumor growth, and inhibition of miR-21 increased it. Downregulation of transforming growth factor beta receptor II (TGFBR2), but not of signal transducer and activator of transcription 3, in hADSCs showed effects similar to those of miR-21 overexpression. Downregulation of TGFBR2 and overexpression of miR21 decreased tumor vascularity. Inhibition of miR-21 and the addition of TGF-{beta} increased the levels of vascular endothelial growth factor and interleukin-6 in hADSCs. Transplantation of miR-21 inhibitor-transfected hADSCs increased blood flow recovery in a hind limb ischemia model of nude mice, compared with transplantation of control oligo-transfected cells. These findings indicate that MSCs might favor tumor growth in vivo. Thus, it is necessary to study the long-term safety of this technique before MSCs can be used as therapeutic tools in regenerative medicine and tissue engineering.

  14. Targeting miR-21 enhances the sensitivity of human colon cancer HT-29 cells to chemoradiotherapy in vitro

    SciTech Connect

    Deng, Jun; Lei, Wan; Fu, Jian-Chun; Zhang, Ling; Li, Jun-He; Xiong, Jian-Ping

    2014-01-17

    Highlight: MiR-21 plays a significant role in 5-FU resistance. This role might be attributed to targeting of hMSH2 as well as TP and DPD via miR-21 targeted hMSH2. Indirectly targeted TP and DPD to influence 5-FU chemotherapy sensitivity. -- Abstract: 5-Fluorouracil (5-FU) is a classic chemotherapeutic drug that has been widely used for colorectal cancer treatment, but colorectal cancer cells are often resistant to primary or acquired 5-FU therapy. Several studies have shown that miR-21 is significantly elevated in colorectal cancer. This suggests that this miRNA might play a role in this resistance. In this study, we investigated this possibility and the possible mechanism underlying this role. We showed that forced expression of miR-21 significantly inhibited apoptosis, enhanced cell proliferation, invasion, and colony formation ability, promoted G1/S cell cycle transition and increased the resistance of tumor cells to 5-FU and X radiation in HT-29 colon cancer cells. Furthermore, knockdown of miR-21 reversed these effects on HT-29 cells and increased the sensitivity of HT-29/5-FU to 5-FU chemotherapy. Finally, we showed that miR-21 targeted the human mutS homolog2 (hMSH2), and indirectly regulated the expression of thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD). These results demonstrate that miR-21 may play an important role in the 5-FU resistance of colon cancer cells.

  15. "Title","Creator/Author","Publication Date","OSTI Identifier...

    Office of Scientific and Technical Information (OSTI)

    Group Flows, Cycles, and<mi>c>-Theorem Folklore","Curtright, Thomas L.; Jin, Xiang; Zachos, Cosmas K.","2012-03-01T05:00:00Z",1098601,"10.1103...

  16. West Berkeley Public Library

    Building Catalog

    Berkeley, CA The West Berkeley Public Library, first opened in December 2013, is the first publicly funded Zero Net Energy public library in California. The library takes advantage of many innovative technologies and passive design strategies to achieve its Zero Net Energy goals. The project's Building Team, led by Harley Ellis Deveraux, partnered with PG&E's Savings By Design program to perform early-stage design analyses including climate modeling, computational fluid dynamics, daylighting, solar modeling, and energy simulations. 04/01/2016 - 15:28

  17. miR-502 inhibits cell proliferation and tumor growth in hepatocellular carcinoma through suppressing phosphoinositide 3-kinase catalytic subunit gamma

    SciTech Connect

    Chen, Suling; Li, Fang; Chai, Haiyun; Tao, Xin; Wang, Haili; Ji, Aifang

    2015-08-21

    MicroRNAs (miRNAs) play a key role in carcinogenesis and tumor progression in hepatocellular carcinoma (HCC). In the present study, we demonstrated that miR-502 significantly inhibits HCC cell proliferation in vitro and tumor growth in vivo. G1/S cell cycle arrest and apoptosis of HCC cells were induced by miR-502. Phosphoinositide 3-kinase catalytic subunit gamma (PIK3CG) was identified as a direct downstream target of miR-502 in HCC cells. Notably, overexpression of PIK3CG reversed the inhibitory effects of miR-502 in HCC cells. Our findings suggest that miR-502 functions as a tumor suppressor in HCC via inhibition of PI3KCG, supporting its utility as a promising therapeutic gene target for this tumor type. - Highlights: • miR-502 suppresses HCC cell proliferation in vitro and tumorigenicity in vivo. • miR-502 regulates cell cycle and apoptosis in HCC cells. • PIK3CG is a direct target of miR-502. • miR-502 and PIK3CG expression patterns are inversely correlated in HCC tissues.

  18. RLIP76-dependent suppression of PI3K/AKT/Bcl-2 pathway by miR-101 induces apoptosis in prostate cancer

    SciTech Connect

    Yang, Jing; Song, Qi; Cai, Yi; Wang, Peng; Wang, Min; Zhang, Dong

    2015-08-07

    MicroRNA-101 (miR-101) participates in carcinogenesis and tumor progression in various cancers. However, its biological functions in prostate cancer are still unclear. Here, we demonstrate that miR-101 represents a critical role in regulating cell apoptosis in prostate cancer cells. We first demonstrated that miR-101 treatment promoted apoptosis in DU145 and PC3 cells by using flow cytometric analysis and transmission electron microscopy (TEM). To verify the mechanisms, we identified a novel miR-101 target, Ral binding protein 1 (RLIP76). We found miR-101 transfection significantly suppresses RLIP76 expression, which can transactivate phosphorylation of PI3K-Akt signaling, and resulted in an amplification of Bcl2-induced apoptosis. Furthermore, we demonstrated that RLIP76 overexpression could reverse the anti-tumor effects of miR-101 in DU145 and PC3 cells by using flow cytometry assay and MTT assay. Taken together, our results revealed that the effect of miR-101 on prostate cancer cell apoptosis was due to RLIP76 regulation of the PI3K/Akt/Bcl-2 signaling pathway. - Highlights: • miR-101 inhibited prostate cancer cell proliferation and enhanced apoptosis. • miR-101 directly targeted and regulated RLIP76 expression. • miR-101 suppressed PI3K/Akt/Bcl-2 signaling pathway by targeting RLIP76.

  19. MiR-20a Induces Cell Radioresistance by Activating the PTEN/PI3K/Akt Signaling Pathway in Hepatocellular Carcinoma

    SciTech Connect

    Zhang, Yuqin; Zheng, Lin; Ding, Yi; Li, Qi; Wang, Rong; Liu, Tongxin; Sun, Quanquan; Yang, Hua; Peng, Shunli; Wang, Wei; Chen, Longhua

    2015-08-01

    Purpose: To investigate the role of miR-20a in hepatocellular carcinoma (HCC) cell radioresistance, which may reveal potential strategies to improve treatment. Methods and Materials: The expression of miR-20a and PTEN were detected in HCC cell lines and paired primary tissues by quantitative real-time polymerase chain reaction. Cell radiation combined with colony formation assays was administrated to discover the effect of miR-20a on radiosensitivity. Bioinformatics prediction and luciferase assay were used to identify the target of miR-20a. The phosphatidylinositol 3-kinase inhibitor LY294002 was used to inhibit phosphorylation of Akt, to verify whether miR-20a affects HCC cell radioresistance through activating the PTEN/PI3K/Akt pathway. Results: MiR-20a levels were increased in HCC cell lines and tissues, whereas PTEN was inversely correlated with it. Overexpression of miR-20a in Bel-7402 and SMMC-7721 cells enhances their resistance to the effect of ionizing radiation, and the inhibition of miR-20a in HCCLM3 and QGY-7701 cells sensitizes them to it. PTEN was identified as a direct functional target of miR-20a for the induction of radioresistance. Overexpression of miR-20a activated the PTEN/PI3K/Akt signaling pathway. Additionally, the kinase inhibitor LY294002 could reverse the effect of miR-20a–induced radioresistance. Conclusion: MiR-20a induces HCC cell radioresistance by activating the PTEN/PI3K/Akt pathway, which suggests that miR-20a/PTEN/PI3K/Akt might represent a target of investigation for developing effective therapeutic strategies against HCC.

  20. Alternative Fuels Data Center: Publications

    Alternative Fuels and Advanced Vehicles Data Center

    Publications Printable Version Share this resource Send a link to Alternative Fuels Data Center: Publications to someone by E-mail Share Alternative Fuels Data Center: Publications on Facebook Tweet about Alternative Fuels Data Center: Publications on Twitter Bookmark Alternative Fuels Data Center: Publications on Google Bookmark Alternative Fuels Data Center: Publications on Delicious Rank Alternative Fuels Data Center: Publications on Digg Find More places to share Alternative Fuels Data

  1. Publications-PHaSe-EFRC

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications Publications of 2014 Publications of 2013 Publications of 2012 Publications of 2011 Publications of 2010 Publications of 2009 2015 Last update 30 April 2015. Jung, Jae Woong; Liu, Feng;Russel, Thomas P.; Ho Jo, Won "Anthracene-Based Medium Bandgap Conjugated Polymers for High Performance Polymer Solar Cells Exceeding 8% PCE Without Additive and Annealing Process", Adv. Energy, Mater., [early view], (2015). DOI: 10.1002/aenm.201500065 Karak, Supravat; Page, Zachariah A;

  2. 2016 Publications | Argonne National Laboratory

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    2016 Publications 2015 Publications News & Events Upcoming Events Press Releases Feature Stories In the News Videos Downloads About HEP at Work Career Opportunities Staff Directory About HEP at Work Career Opportunities Staff Directory Argonne National Laboratory High Energy Physics Research Facilities Capabilities Initiatives Publications News & Events Publications 2016 Publications 2015 Publications 2016 Publications Berger, Joshua, Matthew Cahill-Rowley, Diptimoy Ghosh, JoAnne

  3. Public Comment Opportunities

    Energy.gov [DOE]

    Comments on the Draft EIS and Presidential permit can be submitted verbally during public hearings or in writing to Dr. Julie A Smith at: Office of Electricity Delivery and Energy Reliability (OE...

  4. Public Information Campaigns

    Energy.gov [DOE]

    The U.S. Department of Energy (DOE) supports states, local governments, and tribes in their efforts to carry out education campaigns targeting the general public about energy conservation. These...

  5. Flight Path 5 - Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    - Publications Target 1 Flight Path 05 (1FP05) utilizes low-energy neutrons from a water moderator on the 1L target. Energy resolved neutron radiography at LANSCE pulsed neutron ...

  6. Sandia National Laboratories: Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Facebook Twitter YouTube Flickr RSS Pathfinder Airborne ISR Systems Publications Sandia National Laboratories: Synthetic Aperature Radar (SAR): Publications Reports authored by Sandia National Laboratories 63 results OSTI ID Report No. Type Title Authors Pub. Date Researcher Sponsor 1121978 Full Text Available SAND2013-10619 Technical Report Window taper functions for subaperture processing. Doerry, Armin Walter Dec. 2013 Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

  7. Publications | Argonne National Laboratory

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications Publication Type - Any - Book Book Chapter Conference Paper Conference Proceedings Journal Journal Article Magazine Article Miscellaneous Presentation Report Year - Any - 15 1985 1988 1989 1990 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 Author - Any - Abarzhi, S. I. Abate, J. Abdel-khalik, H. S. Abeysuriya, R. Abhishek, K. Abhyankar, S. Abhyankar, Shrirang Abla, G. Abou-Kandil, H. Abraham, J. A.

  8. Publications | Buildings | NREL

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications NREL publishes a variety of documents related to its research, including technical reports, brochures, and presentations. Read the information below to find out how to find a publication about buildings research at NREL. Accessing Research Papers Buildings Technical Highlights Research Papers - Commercial Research Papers - Residential Accessing Buildings Research Documents Documents produced by NREL related to buildings technologies may be accessed online in several different ways.

  9. Modeling & Simulation publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Modeling and Simulation in the Chemical Sciences » Modeling & Simulation Publications Modeling & Simulation publications Research into alternative forms of energy, especially energy security, is one of the major national security imperatives of this century. Get Expertise David Harradine Physical Chemistry and Applied Spectroscopy Email Josh Smith Chemistry Email The inherent knowledge of transformation has beguiled sorcerers and scientists alike. D.A. Horner, F. Lambert, J.D. Kress,

  10. ORISE: Science Education Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Science Education Publications ORISE reports track U.S. scientific workforce trends The Oak Ridge Institute for Science and Education (ORISE) has published several reports that analyze labor trends, assess classroom technologies and examine other characteristics essential for enhancing America's global competitiveness. The following publications are available as PDF files. To view them, you will need the free Adobe Reader plug-in. Nuclear Engineering Nuclear Engineering Enrollments and Degrees

  11. Sudip Dosanjh: Select Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Dosanjh » Sudip Dosanjh: Select Publications Sudip Dosanjh: Select Publications Sort by: Date | Author | Type 2015 C.S. Daley, L. Ramakrishnan, S. Dosanjh, N.J. Wright, "Analyses of Scientific Workflows for Effective Use of Future Architectures", The 6th International Workshop on Big Data Analytics: Challenges, and Opportunities (BDAC-15), 2015, 2014 Sudip Dosanjh, Shane Canon, Jack Deslippe, Kjiersten Fagnan, Richard Gerber, Lisa Gerhardt, Jason Hick, Douglas Jacobsen, David Skinner,

  12. Is Open to Public

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    4 Severe Weather Workshop, March 4-6, 2004, Is Open to Public Weather enthusiasts may attend the Fourth Annual National Severe Weather Workshop on March 4-6, 2004, at the Marriott Convention Center in Norman, Oklahoma. The workshop, which is open to the public, is designed for emergency managers, storm spotters, and other weather watchers. The country's leading severe weather experts will be discussing their latest research and forecasting techniques. Discussion topics will include new radar

  13. Jefferson Lab Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications Privacy and Security Notice Skip over navigation Search the JLab Site Search Please upgrade your browser. This site's design is only visible in a graphical browser that supports web standards, but its content is accessible to any browser. Concerns? Jefferson Lab Navigation Home Search News Insight print version Research Publications Application On Target Newsletter EHS Manual Property Manual JSA/DOE Contract Acquisition Policy Manual Acquisition Policy Manual Jefferson Lab

  14. LANSCE | Lujan Center | Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Department of Energy, National Nuclear Security Administration nnsa.energy.gov Publications 2009 Publications Please use the following acknowledgement when publishing results based on data measured at the Lujan Center: "This work has benefited from the use of [add here name of specific Lujan instruments] at the Lujan Center at Los Alamos Neutron Science Center, funded by DOE Office of Basic Energy Sciences. Los Alamos National Laboratory is operated by Los Alamos National Security LLC

  15. Biosecurity and Public Health

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Biosecurity and Public Health Biosecurity and Public Health Los Alamos scientists are developing science and technology to improve pathogen detection, create better therapeutics, and anticipate-even prevent-epidemics and pandemics. Contact Us Group Leader Alina Deshpande Email Deputy Group Leader Jeanne Fair Email Group Office (505) 667-2690 Profile pages header Search our Profile pages Los Alamos scientist prepares a sample for screening in a flow cytometer. Ramesh Jha prepares a sample for

  16. MiR-145 is downregulated in human ovarian cancer and modulates cell growth and invasion by targeting p70S6K1 and MUC1

    SciTech Connect

    Wu, Huijuan; Xiao, ZhengHua; Wang, Ke; Liu, Wenxin; Hao, Quan

    2013-11-29

    Highlights: •MiR-145 is downregulated in human ovarian cancer. •MiR-145 targets p70S6K1 and MUC1. •p70S6K1 and MUC1 are involved in miR-145 mediated tumor cell growth and cell invasion, respectively. -- Abstract: MicroRNAs (miRNAs) are a family of small non-coding RNA molecules that regulate gene expression at post-transcriptional levels. Previous studies have shown that miR-145 is downregulated in human ovarian cancer; however, the roles of miR-145 in ovarian cancer growth and invasion have not been fully demonstrated. In the present study, Northern blot and qRT-PCR analysis indicate that miR-145 is downregulated in ovarian cancer tissues and cell lines, as well as in serum samples of ovarian cancer, compared to healthy ovarian tissues, cell lines and serum samples. Functional studies suggest that miR-145 overexpression leads to the inhibition of colony formation, cell proliferation, cell growth viability and invasion, and the induction of cell apoptosis. In accordance with the effect of miR-145 on cell growth, miR-145 suppresses tumor growth in vivo. MiR-145 is found to negatively regulate P70S6K1 and MUC1 protein levels by directly targeting their 3′UTRs. Importantly, the overexpression of p70S6K1 and MUC1 can restore the cell colony formation and invasion abilities that are reduced by miR-145, respectively. MiR-145 expression is increased after 5-aza-CdR treatment, and 5-aza-CdR treatment results in the same phenotype as the effect of miR-145 overexpression. Our study suggests that miR-145 modulates ovarian cancer growth and invasion by suppressing p70S6K1 and MUC1, functioning as a tumor suppressor. Moreover, our data imply that miR-145 has potential as a miRNA-based therapeutic target for ovarian cancer.

  17. Development of Optimal Catalyst Designs and Operating Strategies...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. PDF icon p-05harold.pdf More Documents ...

  18. Optical Measurement Methods used in Calibration and Validation...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. PDF icon p-07klyza.pdf More Documents ...

  19. Stoney Corners II (REpower) | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    Developer Heritage Sustainable Energy Energy Purchaser Traverse City Light & PowerDetroit Edison Location McBain MI Coordinates 44.209, -85.275 Show Map Loading map......

  20. On-Road PM Mass Emission Measured with OBS-TRPM | Department...

    Energy.gov [DOE] (indexed site)

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. p-14wei.pdf (310.84 KB) More Documents ...

  1. Actively controlled vibration welding system and method (Patent...

    Office of Scientific and Technical Information (OSTI)

    OSTI Identifier: 1083924 Assignee: GM Global Technology Operations LLC (Detroit, MI) DOEEE Patent Number(s): 8,408,445 Application Number: 13409,494 Contract Number: EE0002217 ...

  2. Shape memory alloy heat engines and energy harvesting systems...

    Office of Scientific and Technical Information (OSTI)

    Assignee: GM Global Technology Operations LLC (Detroit, MI); Dynalloy, Inc. (Tustin, CA) ARPA-E Patent Number(s): 8,607,562 Application Number: 13340,955 Contract Number: ...

  3. Improving Diesel Engine Sweet-spot Efficiency and Adapting it...

    Energy.gov [DOE] (indexed site)

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. p-18yan.pdf (213.42 KB) More Documents ...

  4. The Impact of Using Derived Fuel Consumption Maps to Predict...

    Energy.gov [DOE] (indexed site)

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. p-09nuszkowski.pdf (76.33 KB) More ...

  5. Analyses Guided Optimization of Wide Range and High Efficiency...

    Energy.gov [DOE] (indexed site)

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. deer10sun.pdf (999.91 KB) More ...

  6. EA-1690: A123 Systems, Inc., Automotive-Class Lithium-Ion Battery...

    Energy Saver

    0: A123 Systems, Inc., Automotive-Class Lithium-Ion Battery Production Facilities near Detroit, MI EA-1690: A123 Systems, Inc., Automotive-Class Lithium-Ion Battery Production ...

  7. Enhancing Heat Recovery for Thermoelectric Devices | Department...

    Energy.gov [DOE] (indexed site)

    Presentation given at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. deer10szybist2.pdf (936.96 KB) More ...

  8. Integrated Nozzle Flow, Spray, Combustion, & Emission Modeling...

    Energy.gov [DOE] (indexed site)

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. p-13som.pdf (285.53 KB) More Documents ...

  9. Reductant Chemistry during LNT Regeneration for a Lean Gasoline...

    Energy.gov [DOE] (indexed site)

    Poster presented at the 16th Directions in Engine-Efficiency and Emissions Research (DEER) Conference in Detroit, MI, September 27-30, 2010. p-09parks.pdf (507.29 KB) More ...

  10. EIS-0431: Extension of public comment period; Notice of public...

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    EIS-0431: Extension of public comment period; Notice of public hearing (Correction) Hydrogen Energy California's Integrated Gasification Combined Cycle and Carbon Capture and ...

  11. Public Scoping Meeting and Public Scoping Period for a Proposed...

    Energy Saver

    public input on the scope of an Environmental Assessment for "Project Icebreaker". ... The public is invited to submit written comments on the scope of issues and resources and ...

  12. Technical Publications | Department of Energy

    Office of Environmental Management (EM)

    Technical Publications Listed below are publications either authored or co-authored by CNS staff. The web links for these publications lead to non-DOE websites. Comparison of the ...

  13. The long non-coding RNA H19-derived miR-675 modulates human gastric cancer cell proliferation by targeting tumor suppressor RUNX1

    SciTech Connect

    Zhuang, Ming; Gao, Wen; Xu, Jing; Wang, Ping; Shu, Yongqian

    2014-06-06

    Graphical abstract: - Highlights: • H19 regulates gastric cancer cell proliferation phenotype via miR-675. • MiR-675 modulates cell proliferation of gastric cancer cells by targeting tumor suppressor RUNX1. • The H19/miR-675/RUNX1 axis plays an important role in the tumorigenesis of gastric cancer. - Abstract: The lncRNA H19 has been recently shown to be upregulated and play important roles in gastric cancer tumorigenesis. However, the precise molecular mechanism of H19 and its mature product miR-675 in the carcinogenesis of gastric cancer remains unclear. In this study, we found that miR-675 was positively expressed with H19 and was a pivotal mediator in H19-induced gastric cancer cell growth promotion. Subsequently, the tumor suppressor Runt Domain Transcription Factor1 (RUNX1) was confirmed to be a direct target of miR-675 using a luciferase reporter assay and Western blotting analyses. A series of rescue assays indicated that RUNX1 mediated H19/miR-67-induced gastric cancer cell phenotypic changes. Moreover, the inverse relationship between the expression of RUNX1 and H19/miR-675 was also revealed in gastric cancer tissues and gastric cancer cell lines. Taken together, our study demonstrated that the novel pathway H19/miR-675/RUNX1 regulates gastric cancer development and may serve as a potential target for gastric cancer therapy.

  14. DOE - NNSA/NFO -- Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications NNSANFO Language Options U.S. DOENNSA - Nevada Field Office The Publications Library section includes the SiteLines newsletter, NFO Strategic Plan, Environmental ...

  15. Testing CPT conservation using the NuMI neutrino beam with the MINOS experiment

    SciTech Connect

    Auty, David John

    2010-05-01

    The MINOS experiment was designed to measure neutrino oscillation parameters with muon neutrinos. It achieves this by measuring the neutrino energy spectrum and flavor composition of the man-made NuMI neutrino beam 1km after the beam is formed and again after 735 km. By comparing the two spectra it is possible to measure the oscillation parameters. The NuMI beam is made up of 7.0% {bar {nu}}{sub {mu}}, which can be separated from the {nu}{sub {mu}} because the MINOS detectors are magnetized. This makes it possible to study {bar {nu}}{sub {mu}} oscillations separately from those of muon neutrinos, and thereby test CPT invariance in the neutrino sector by determining the {bar {nu}}{sub {mu}} oscillation parameters and comparing them with those for {nu}{sub {mu}}, although any unknown physics of the antineutrino would appear as a difference in oscillation parameters. Such a test has not been performed with beam {bar {nu}}{sub {mu}} before. It is also possible to produce an almost pure {bar {nu}}{sub {mu}} beam by reversing the current through the magnetic focusing horns of the NuMI beamline, thereby focusing negatively, instead of positively charged particles. This thesis describes the analysis of the 7% {bar {nu}}{sub {mu}} component of the forward horn current NuMI beam. The {bar {nu}}{sub {mu}} of a data sample of 3.2 x 10{sup 20} protons on target analysis found 42 events, compared to a CPT conserving prediction of 58.3{sub -7.6}{sup +7.6}(stat.){sub -3.6}{sup +3.6}(syst.) events. This corresponds to a 1.9 {sigma} deficit, and a best fit value of {Delta}{bar m}{sub 32}{sup 2} = 18 x 10{sup -3} eV{sup 2} and sin{sup 2} 2{bar {theta}}{sub 23} = 0.55. This thesis focuses particularly on the selection of {bar {nu}}{sub {mu}} events, and investigates possible improvements of the selection algorithm. From this a different selector was chosen, which corroborated the findings of the original selector. The thesis also investigates how the systematic errors affect the

  16. ,"Marysville, MI Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Marysville, MI Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  17. Port Huron, MI Natural Gas Pipeline Imports From Canada (Dollars per

    Energy Information Administration (EIA) (indexed site)

    Thousand Cubic Feet) Dollars per Thousand Cubic Feet) Port Huron, MI Natural Gas Pipeline Imports From Canada (Dollars per Thousand Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2016 2.07 2.06 2.21 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Price of

  18. ,"St. Clair, MI Natural Gas Pipeline Exports to Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Exports to Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","St. Clair, MI Natural Gas Pipeline Exports to Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  19. ,"St. Clair, MI Natural Gas Pipeline Imports From Canada (MMcf)"

    Energy Information Administration (EIA) (indexed site)

    Imports From Canada (MMcf)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","St. Clair, MI Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release Date:","11/30/2016" ,"Excel File

  20. ARM - Publications Article

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    CenterPublicationsPublications Article Media Contact Hanna Goss hanna-dot-goss-at-pnnl-dot-gov @armnewsteam Field Notes Blog Topics Field Notes118 AGU 3 AMIE 10 ARM Aerial Facility 2 ARM Mobile Facility 1 7 ARM Mobile Facility 2 47 ARM Mobile Facility 3 1 BAECC 1 BBOP 4 CARES 1 Data Quality Office 2 ENA 2 GOAMAZON 7 HI-SCALE 5 LASIC 3 MAGIC 15 MC3E 17 PECAN 3 SGP 8 STORMVEX 29 TCAP 3 Search News Search Blog News Center All Categories What's this? Social Media Guidance News Center All Categories

  1. JLF Science Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    science publications JLF Science Publications 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2003-06 Title Author Source Detailed characterization of the LLNL imaging proton spectrometer A. M. Rasmus et al. Rev. Sci. Instrum. 87, 11D831 High-Intensity laser-accelerated ion beam produced from cryogenic micro-jet target M. Gauthier et al. Rev. Sci. Instrum. 87, 11D827 High resolution spectrometer for extended x-ray absorption fine structure measurements in the 6 keV to 15 keV range J. F. Seely

  2. Commitment to Public Involvement

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Create a Sustainable Future » Commitment to Public Involvement Commitment to Public Involvement LANL is committed to our neighbors August 1, 2013 Lab Director McMillan talks with Lab historian Ellen McGhee during Lab tour Lab Director McMillan talks with Lab historian Ellen McGhee during Lab tour RELATED IMAGES http://farm4.staticflickr.com/3815/9442115459_390e5bc841_t.jpg Enlarge http://farm8.staticflickr.com/7111/7650961650_ed1571174f_t.jpg Enlarge

  3. Publications | Department of Energy

    Energy Saver

    | Department of Energy Public Utility Awards EM's Idaho Site Contractor for Energy Conservation Public Utility Awards EM's Idaho Site Contractor for Energy Conservation January 27, 2016 - 12:00pm Addthis Displaying the reward of a team effort between CWI and Idaho Power, from left to right, are Jim Floerke, Chuck Urbanski, and Brian Preussner, all with CWI, and Bo Hanchey and Vern Porter with Idaho Power. Displaying the reward of a team effort between CWI and Idaho Power, from left to right,

  4. QTR Public Webinar 1

    Office of Energy Efficiency and Renewable Energy (EERE)

    This is the second public webinar hosted by the Office of the Under Secretary for Science and Energy to describe work in progress on the QTR 2015. The comment process following this webinar, will provide an opportunity for stakeholders and experts to provide input.

  5. Public Benefit Funds Resources

    Energy.gov [DOE]

    State and/or local financial incentives and programs help building owners execute energy efficiency projects by lowering cost burdens through public benefits funds, grants, loans, or property-assessed clean energy financing; personal, corporate, property, and sales tax incentives; or assistance with permitting fee reduction or elimination.

  6. Assessment of radiological releases from the NuMI facility during MINOS and NOvA operations

    SciTech Connect

    Martens, Mike; /Fermilab

    2007-04-01

    This report makes projections of the radiological releases from the NuMI facility during operations for the MINOS and NO ?A experiments. It includes an estimate of the radionuclide levels released into the atmosphere and the estimated tritium and sodium-22 concentrations in the NuMI sump water and Fermilab pond system. The analysis was performed for NuMI operations with a beam power on target increased from the present 400 kW design up to a possible 1500 kW with future upgrades. The total number of protons on target was assumed to be 18 x 10{sup 20} after the completion of MINOS and 78 x 10{sup 20} after the completion of NO ?A.

  7. Identification of miR-2400 gene as a novel regulator in skeletal muscle satellite cells proliferation by targeting MYOG gene

    SciTech Connect

    Zhang, Wei Wei; Tong, Hui Li; Sun, Xiao Feng; Hu, Qian; Yang, Yu; Li, Shu Feng; Yan, Yun Qin; Li, Guang Peng

    2015-08-07

    MicroRNAs play critical roles in skeletal muscle development as well as in regulation of muscle cell proliferation and differentiation. Previous study in our laboratory showed that the expression level of miR-2400, a novel and unique miRNA from bovine, had significantly changed in skeletal muscle-derived satellite cells (MDSCs) during differentiation, however, the function and expression pattern for miR-2400 in MDSCs has not been fully understood. In this report, we firstly identified that the expression levels of miR-2400 were down-regulated during MDSCs differentiation by stem-loop RT-PCR. Over-expression and inhibition studies demonstrated that miR-2400 promoted MDSCs proliferation by EdU (5-ethynyl-2′ deoxyuridine) incorporation assay and immunofluorescence staining of Proliferating cell nuclear antigen (PCNA). Luciferase reporter assays showed that miR-2400 directly targeted the 3′ untranslated regions (UTRs) of myogenin (MYOG) mRNA. These data suggested that miR-2400 could promote MDSCs proliferation through targeting MYOG. Furthermore, we found that miR-2400, which was located within the eighth intron of the Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) gene, was down-regulated in MDSCs in a direct correlation with the WHSC1L1 transcript by Clustered regularly interspaced palindromic repeats interference (CRISPRi). In addition, these observations not only provided supporting evidence for the codependent expression of intronic miRNAs and their host genes in vitro, but also gave insight into the role of miR-2400 in MDSCs proliferation. - Highlights: • miR-2400 is a novel and unique miRNA from bovine. • miR-2400 could promote skeletal muscle satellite cells proliferation. • miR-2400 directly targeted the 3′ untranslated regions of MYOG mRNA. • miR-2400 could be coexpressed together with its host gene WHSC1L1.

  8. miR-340 inhibits glioblastoma cell proliferation by suppressing CDK6, cyclin-D1 and cyclin-D2

    SciTech Connect

    Li, Xuesong; Gong, Xuhai; Chen, Jing; Zhang, Jinghui; Sun, Jiahang; Guo, Mian

    2015-05-08

    Glioblastoma development is often associated with alteration in the activity and expression of cell cycle regulators, such as cyclin-dependent kinases (CKDs) and cyclins, resulting in aberrant cell proliferation. Recent studies have highlighted the pivotal roles of miRNAs in controlling the development and growth of glioblastoma. Here, we provide evidence for a function of miR-340 in the inhibition of glioblastoma cell proliferation. We found that miR-340 is downregulated in human glioblastoma tissue samples and several established glioblastoma cell lines. Proliferation and neurosphere formation assays revealed that miR-340 plays an oncosuppressive role in glioblastoma, and that its ectopic expression causes significant defect in glioblastoma cell growth. Further, using bioinformatics, luciferase assay and western blot, we found that miR-340 specifically targets the 3′UTRs of CDK6, cyclin-D1 and cyclin-D2, leading to the arrest of glioblastoma cells in the G0/G1 cell cycle phase. Confirming these results, we found that re-introducing CDK6, cyclin-D1 or cyclin-D2 expression partially, but significantly, rescues cells from the suppression of cell proliferation and cell cycle arrest mediated by miR-340. Collectively, our results demonstrate that miR-340 plays a tumor-suppressive role in glioblastoma and may be useful as a diagnostic biomarker and/or a therapeutic avenue for glioblastoma. - Highlights: • miR-340 is downregulated in glioblastoma samples and cell lines. • miR-340 inhibits glioblastoma cell proliferation. • miR-340 directly targets CDK6, cyclin-D1, and cyclin-D2. • miR-340 regulates glioblastoma cell proliferation via CDK6, cyclin-D1 and cyclin-D2.

  9. DOE - NNSA/NFO -- Environmental Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Environmental Publications NNSANFO Language Options U.S. DOENNSA - Nevada Field Office Environmental Publications NNSANFO publications concerning environmental programs are ...

  10. Public Access Policy and Communications | DOE PAGES

    Office of Scientific and Technical Information (OSTI)

    Public Access Policy and Communications Public Access Policy and Communications 72414 Department of Energy Public Access Plan DOE Public Access Plan 22213 White House Office of ...

  11. Public Access Policy and Communications | DOE PAGES

    Office of Scientific and Technical Information (OSTI)

    DOE PAGES Public Access Policy and Communications Public Access Policy and Communications 72414 Department of Energy Public Access Plan DOE Public Access Plan 22213 White House ...

  12. CSC Public Meeting Agenda | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Public Meeting Agenda CSC Public Meeting Agenda PDF icon CSC Public Meeting Agenda More Documents & Publications 2012 Peer Review Overview Agenda FINALAPRILSEABAGENDA.pdf Spectrum ...

  13. Public Affairs | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    Field Offices Sandia National Laboratory Public Affairs Public Affairs The SFO Public Affairs Director is responsible for all public affairs matters connected with the...

  14. ,"Sault St Marie, MI Natural Gas Pipeline Exports to Canada (Million Cubic Feet)"

    Energy Information Administration (EIA) (indexed site)

    Sault St Marie, MI Natural Gas Pipeline Exports to Canada (Million Cubic Feet)" ,"Click worksheet name or tab at bottom for data" ,"Worksheet Name","Description","# Of Series","Frequency","Latest Data for" ,"Data 1","Sault St Marie, MI Natural Gas Pipeline Exports to Canada (Million Cubic Feet)",1,"Annual",2015 ,"Release Date:","10/31/2016" ,"Next Release

  15. Management of Public Communications Publications, and Scientific, Engineering, and Technical Publications

    Directives, Delegations, and Other Requirements [Office of Management (MA)]

    1979-08-10

    This order prescribes policies, standards, and procedures for effective management of Department of Energy (DOE) publications.

  16. Sandia National Laboratories: Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    CMC Publications Visiting Research Scholars' Papers | Formal Documents | Other Papers and Journals | CMC Factsheet Visiting Research Scholars' Papers SAND 2015-0233 Nuclear Security Governance in India: Institutions, Instruments, and Culture Authors: Sitakanta Mishra and Happymon Jacob SAND 2014-1749P Pakistan's Strategic Culture: Formulation of Counterterrorism Policy Author: Dr. Muhammad Tehsin SAND 2014-19982R Iran's Relations to the East: Nonproliferation and Regional Security in a Changing

  17. Public Key FPGA Software

    Energy Science and Technology Software Center

    2013-07-25

    The Public Key (PK) FPGA software performs asymmetric authentication using the 163-bit Elliptic Curve Digital Signature Algorithm (ECDSA) on an embedded FPGA platform. A digital signature is created on user-supplied data, and communication with a host system is performed via a Serial Peripheral Interface (SPI) bus. Software includes all components necessary for signing, including custom random number generator for key creation and SHA-256 for data hashing.

  18. EIA publications directory 1996

    SciTech Connect

    1997-05-01

    This edition of the EIA Publications Directory contains titles and abstracts of periodicals and one-time reports produced by the Energy Information Administration (EIA) from January through December 1996. The body of the Directory contains citations and abstracts arranged by broad subject categories; metadata, coal, oil and gas, nuclear, electricity, renewable and energy/alternative fuels, multifuel, end-use consumption, models, and forecasts.

  19. APPENDIX A PUBLIC SCOPING

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    APPENDIX A PUBLIC SCOPING THIS PAGE INTENTIONALLY LEFT BLANK NOTICE OF SCOPING The U.S. Department of Energy (DOE) is preparing a draft Environmental Assessment to analyze and describe the potential environmental impacts associated with proposed actions at the: National Wind Technology Center (DOE/EA-1914) Jefferson County, Colorado The DOE is proposing to analyze future improvements to the existing National Renewable Energy Laboratory's (NREL) National Wind Technology Center (NWTC). DOE's

  20. EIA publications directory 1997

    SciTech Connect

    1998-04-01

    This edition of the EIA Publications Directory contains 68 titles and abstracts of periodicals and one time reports produced by EIA from January through December 1997. The body of the Directory contains citations and abstracts arranged by broad subject categories; (1) MetaData, (2) Coal, (3) Oil (4) Natural gas, (5) Nuclear, (6) Electricity, (7) Renewable energy and Alternative fuels, (8) Multifuel, (9) End use consumption, (10) Models, and (11) Forecasts.

  1. Fermilab | Publications and Videos

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications and Videos Navbar Toggle About Leadership and Organization Leadership bios Organizational chart Committees and Councils Science Photo and Video Gallery History Diversity Education Safety Sustainability and Environment Contact Related Links DOE FRA UChicago URA Newsroom Spotlight Press releases Fact sheets and brochures symmetry Interactions.org Photo and video archive Resources for ... Employees Researchers, postdocs and graduate students Job seekers Neighbors Industry K-12

  2. Innovation Impact Publications | NREL

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Innovation Impact Publications NREL has a rich history of scientific innovation and partnering with industry in research and development across our primary areas of renewable energy and energy efficiency research: analysis, bioenergy, buildings, manufacturing, solar, transportation, and wind technologies. Learn more about NREL's Innovation Impact by viewing the fact sheets below on our key breakthrough results. Analysis NREL Case Study Leads to International Partnership In 2012, NREL analysts

  3. miR-206 is down-regulated in breast cancer and inhibits cell proliferation through the up-regulation of cyclinD2

    SciTech Connect

    Zhou, Jing; Tian, Ye; Li, Juan; Lu, Binbin; Sun, Ming; Zou, Yanfen; Kong, Rong; Luo, Yanhong; Shi, Yongguo; Wang, Keming; Ji, Guozhong

    2013-04-05

    Highlights: ? miR-206 was downexpressed in tumor samples compared with matched normal samples. ? Enhanced expression of miR-206 could inhibit breast cancer growth in vitro. ? Luciferase confirmed miR-206 functions as an anti-oncogene by targeting cyclinD2. ? A reverse correlation between miR-206 and cyclinD2 in breast cancer was found. -- Abstract: MicroRNAs act as important gene regulators in human genomes, and their aberrant expression is linked to many malignancies. Aberrant expression of miR-206 has been frequently reported in cancer studies; however, the role and mechanism of its function in breast cancer remains unclear. Quantitative real-time PCR was performed to detect the relative expression levels of miR-206 in breast cancer and normal breast tissues. Lower expression of miR-206 in breast cancer tissues was associated with larger tumour size and a more advanced clinical stage. Further in vitro observations showed that the enforced expression of miR-206 in MCF-7 breast cancer cells inhibited cell growth by blocking the G1/S transition and suppressed cell proliferation and colony formation, implying that miR-206 functions as a tumour suppressor in the progression of breast cancer. Interestingly, Luciferase assays first revealed that miR-206 inhibited cyclinD2 expression by targeting two binding sites in the 3?-untranslated region of cyclinD2 mRNA. qRT-PCR and Western blot assays verified that miR-206 reduced cyclinD2 expression at both the mRNA and protein levels. A reverse correlation between miR-206 and cyclinD2 expression was noted in breast cancer tissues. Altogether, our results identify a crucial tumour suppressive role of miR-206 in the progression of breast cancer, at least partly via up-regulation of the expression of cyclinD2, and suggest that miR-206 might be a candidate prognostic predictor or an anticancer therapeutic target for breast cancer patients.

  4. MiR-138 promotes smooth muscle cells proliferation and migration in db/db mice through down-regulation of SIRT1

    SciTech Connect

    Xu, Juan; Li, Li; Yun, Hui-fang; Han, Ye-shan

    2015-08-07

    Background: Diabetic vascular smooth muscle cells (VSMCs) exhibit significantly increased rates of proliferation and migration, which was the most common pathological change in atherosclerosis. In addition, the study about the role for miRNAs in the regulation of VSMC proliferation is just beginning to emerge and additional miRNAs involved in VSMC proliferation modulation should be identified. Methods: The expression of miR-138 and SIRT1 were examined in SMCs separated from db/db mice and in SMC lines C-12511 exposed to high glucose with qRT-PCR and western blot. The regulation of miR-138 on the expression of SMCs was detected with luciferase report assay. VSMCs proliferation and migration assays were performed to examine the effect of miR-138 inhibitor on VSMCs proliferation and migration. Results: We discovered that higher mRNA level of miR-138 and reduced expression of SIRT1 were observed in SMCs separated from db/db mice and in SMC lines C-12511. Moreover, luciferase report assay showed that the activity of SIRT1 3′-UTR was highly increased by miR-138 inhibitor and reduced by miR-138 mimic. In addition, we examined that the up-regulation of NF-κB induced by high glucose in SMCs was reversed by resveratrol and miR-138 inhibitor. MTT and migration assays showed that miR-138 inhibitor attenuated the proliferation and migration of smooth muscle cells. Conclusion: In this study, we revealed that miR-138 might promote proliferation and migration of SMC in db/db mice through suppressing the expression of SIRT1. - Highlights: • Higher mRNA level of miR-138 was observed in SMCs from db/db mice. • The mRNA and protein level of SIRT1 in SMCs from db/db mice were greatly reduced. • miR-138 could regulate the expression of SIRT1 in SMCs. • SIRT1 overexpression reversed the up-regulation of acetylized p65 and NF-κB induced by high glucose. • MiR-138 inhibitor reversed VSMCs proliferation and migration induced by high glucose.

  5. Publications > Research > The Energy Materials Center at Cornell

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications In This Section 2016 2015 2014 2013 2012 2011 2010 2009 Publications 2016 Publications 2015 Publications 2014 Publications 2013 Publications 2012 Publications 2011 Publications 2010 Publications 2009 Publications

  6. Coming On Strong | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    & Emissions Research Conference (DEER 2007). 13-16 August, 2007, Detroit, Michigan. ... PDF icon deer07hires.pdf More Documents & Publications Light Duty Diesels in the United ...

  7. Tax Credits, Rebates & Savings | Department of Energy

    Energy.gov [DOE] (indexed site)

    is offering financial assistance to commercial, institutional and public buildings in Detroit that install energy efficiency and ... Eligibility: Commercial, Local Government,...

  8. Tax Credits, Rebates & Savings | Department of Energy

    Energy.gov [DOE] (indexed site)

    DuctAir sealing, Building Insulation, CustomOthers pending approval, Other EE, Personal Computing Equipment, Pool Pumps, LED Lighting Detroit Public Lighting Department-...

  9. ARM News &#187; Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publication Notice: 3 New References Available Thu, 01 Jan 1970 00:00:00 +0000 Publications http://www.arm.gov/publications?date=20161116#20161116 &#60;strong&#62;Lead Author(s)&#60;/strong&#62; Liljegren JC | Del Genio AD | Li Z, &#60;em&#62;Reviews of Geophysics&#60;/em&#62; [...] Publication Notice: New Journal Reference Available Thu, 01 Jan 1970 00:00:00 +0000 Publications http://www.arm.gov/publications?date=20161115#20161115 Ostler A, R Sussmann, PK Patra,

  10. miR-15a/16 Enhances Radiation Sensitivity of Non-Small Cell Lung Cancer Cells by Targeting the TLR1/NF-κB Signaling Pathway

    SciTech Connect

    Lan, Fengming; Yue, Xiao; Ren, Gang; Li, Hongqi; Ping, Li; Wang, Yingjie; Xia, Tingyi

    2015-01-01

    Purpose: Many miRNAs have been identified as essential issues and core determining factors in tumor radiation. Recent reports have demonstrated that miRNAs and Toll-like receptors could exert reciprocal effects to control cancer development in various ways. However, a novel role of miR-15a/16 in enhancing radiation sensitivity by directly targeting TLR1 has not been reported, to our knowledge. Methods and Materials: Bioinformatic analyses, luciferase reporter assay, biochemical assays, and subcutaneous tumor establishment were used to characterize the signaling pathways of miRNA-15a/16 in response to radiation treatment. Results: First, an inverse correlation between the expression of miR-15a/16 and TLR1 protein was revealed in non-small cell lung cancer (NSCLC) and normal lung tissues. Next, we corroborated that miR-15a/16 specifically bound to TLR1 3′UTR and inhibited the expression of TLR1 in H358 and A549 cells. Furthermore, miR-15a/16 downregulated the activity of the NF-κB signaling pathway through TLR1. In addition, overexpression of miR-15a/16 inhibited survival capability and increased radiation-induced apoptosis, resulting in enhancement of radiosensitivity in H358 and A549 cells. Finally, subcutaneous tumor bearing NSCLC cells in a nude mice model was established, and the results showed that combined groups (miR-15a/16 + radiation) inhibited tumor growth more significantly than did radiation alone. Conclusions: We mainly elucidate that miRNA-15a/16 can enhance radiation sensitivity by regulating the TLR1/NF-κB signaling pathway and act as a potential therapeutic approach to overcome radioresistance for lung cancer treatment.

  11. ARM - Publications: Science Team Meeting Documents: Publication Trends of

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ARM Research Publication Trends of ARM Research Troyan, David Brookhaven National Laboratory This study summarizes the publication record of ARM research. Items of all types listed in the ARM Publication Database and published between 1990 and 2003 are included in this analysis. An historical examination of this type can be used to develop future metrics with regard to published materials

  12. St. Clair, MI Natural Gas Pipeline Imports From Canada (Million Cubic Feet)

    Energy Information Administration (EIA) (indexed site)

    Decade Year-0 Year-1 Year-2 Year-3 Year-4 Year-5 Year-6 Year-7 Year-8 Year-9 1990's 14,132 11,855 34,592 33,388 2000's 17,198 21,747 28,441 5,202 22,853 18,281 10,410 9,633 9,104 6,544 2010's 5,591 5,228 3,531 6,019 16,409 9,024 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 10/31/2016 Next Release Date: 11/30/2016 Referring Pages: U.S. Natural Gas Pipeline Imports by Point of Entry St. Clair, MI Natural

  13. Cyclotron Institute » Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications Cyclotron Institute Upgrade White Paper Annual Reports 2015-2016 (full report) 2014-2015 (full report) 2013-2014 (full report) 2012-2013 (full report) 2011-2012 (full report) 2010-2011 (full report) 2009-2010 (full report) 2008-2009 (full report) 2007-2008 (full report) 2006-2007 (full report) 2005-2006 (full report) 2004-2005 (full report) 2003-2004 (full report) 2002-2003 (full report) 2001-2002 2000-2001 1999-2000 1998-1999

  14. EIA publications directory 1994

    SciTech Connect

    1995-07-20

    Enacted in 1977, the Department of Energy (DOE) Organization Act established the Energy Information Administration (EIA) as the Department`s independent statistical and analytical agency, with a mandate to collect and publish data and prepare analyses on energy production, consumption, prices, resources, and projections of energy supply and demand. This edition of the EIA Publications Directory contains titles and abstracts of periodicals and one-time reports produced by EIA from January through December 1994. The body of the Directory contains citations and abstracts arranged by broad subject categories: metadata, coal, oil and gas, nuclear, electricity, renewable energy/alternative fuels, multifuel, end-use consumption, models, and forecasts.

  15. LANSCE | Lujan Center | Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    0 Publications Please use the following acknowledgement when publishing results based on data measured at the Lujan Center: "This work has benefited from the use of [add here name of specific Lujan instruments] at the Lujan Center at Los Alamos Neutron Science Center, funded by DOE Office of Basic Energy Sciences. Los Alamos National Laboratory is operated by Los Alamos National Security LLC under DOE Contract DE-AC52-06NA25396." Year Citation citation # (as of 06/2013) Instrument 115

  16. LANSCE | Lujan Center | Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    1 Publications Please use the following acknowledgement when publishing results based on data measured at the Lujan Center: "This work has benefited from the use of [add here name of specific Lujan instruments] at the Lujan Center at Los Alamos Neutron Science Center, funded by DOE Office of Basic Energy Sciences. Los Alamos National Laboratory is operated by Los Alamos National Security LLC under DOE Contract DE-AC52-06NA25396." Year Citation citation # (as of 06/2013) Instrument 244

  17. LANSCE | Lujan Center | Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    2 Publications Please use the following acknowledgement when publishing results based on data measured at the Lujan Center: "This work has benefited from the use of [add here name of specific Lujan instruments] at the Lujan Center at Los Alamos Neutron Science Center, funded by DOE Office of Basic Energy Sciences. Los Alamos National Laboratory is operated by Los Alamos National Security LLC under DOE Contract DE-AC52-06NA25396." Year Citation citation # (as of 06/2013) Instrument 373

  18. Observation of Disappearance of Muon Neutrinos in the NuMI Beam

    SciTech Connect

    Pavlovic, Zarko

    2008-05-01

    The Main Injector Neutrino Oscillation Search (MINOS) is a two detector long-baseline neutrino experiment designed to study the disappearance of muon neutrinos. MINOS will test the vμ → vτ oscillation hypothesis and measure precisely Δm232 and sin223 oscillation parameters. The source of neutrinos for MINOS experiment is Fermilab's Neutrinos at the Main Injector (NuMI) beamline. The energy spectrum and the composition of the beam is measured at two locations, one close to the source and the other 735 km down-stream in the Soudan Mine Underground Laboratory in northern Minnesota. The precision measurement of the oscillation parameters requires an accurate prediction of the neutrino flux at the Far Detector. This thesis discusses the calculation of the neutrino flux at the Far Detector and its uncertainties. A technique that uses the Near Detector data to constrain the uncertainties in the calculation of the flux is described. The data corresponding to an exposure of 2.5 x 1020 protons on the NuMI target is presented and an energy dependent disappearance pattern predicted by neutrino oscillation hypotheses is observed in the Far Detector data. The fit to MINOS data, for given exposure, yields the best fit values for Δm$2\\atop{23}$ and sin223 to be (2.38$+0.20\\atop{-0.16}$) x 10-3 eV2/c4and 1.00-0.08, respectively.

  19. Validation of the MCNPX-PoliMi Code to Design a Fast-Neutron Multiplicity Counter

    SciTech Connect

    J. L. Dolan; A. C. Kaplan; M. Flaska; S. A. Pozzi; D. L. Chichester

    2012-07-01

    Many safeguards measurement systems used at nuclear facilities, both domestically and internationally, rely on He-3 detectors and well established mathematical equations to interpret coincidence and multiplicity-type measurements for verifying quantities of special nuclear material. Due to resource shortages alternatives to these existing He-3 based systems are being sought. Work is also underway to broaden the capabilities of these types of measurement systems in order to improve current multiplicity analysis techniques. As a part of a Material Protection, Accounting, and Control Technology (MPACT) project within the U.S. Department of Energy's Fuel Cycle Technology Program we are designing a fast-neutron multiplicity counter with organic liquid scintillators to quantify important quantities such as plutonium mass. We are also examining the potential benefits of using fast-neutron detectors for multiplicity analysis of advanced fuels in comparison with He-3 detectors and testing the performance of such designs. The designs are being developed and optimized using the MCNPX-PoliMi transport code to study detector response. In the full paper, we will discuss validation measurements used to justify the use of the MCNPX-PoliMi code paired with the MPPost multiplicity routine to design a fast neutron multiplicity counter with liquid scintillators. This multiplicity counter will be designed with the end goal of safeguarding advanced nuclear fuels. With improved timing qualities associated with liquid scintillation detectors, we can design a system that is less limited by nuclear materials of high activities. Initial testing of the designed system with nuclear fuels will take place at Idaho National Laboratory in a later stage of this collaboration.

  20. T-1025 IU SciBath-768 detector tests in MI-12

    SciTech Connect

    Tayloe, Rex; Cooper, R.; Garrison, L.; Thornton, T.; Rebenitsch, L.; DeJongh, Fritz; Loer, Benjamin; Ramberg, Erik; Yoo, Jonghee; /Fermilab

    2012-02-11

    This is a memorandum of understanding between the Fermi National Accelerator Laboratory (Fermilab) and the experimenters of Department of Physics and Center for Exploration of Energy and Matter, Indiana University, who have committed to participate in detector tests to be carried out during the 2012 Fermilab Neutrino program. The memorandum is intended solely for the purpose of recording expectations for budget estimates and work allocations for Fermilab, the funding agencies and the participating institutions. it reflects an arrangement that currently is satisfactory to the parties; however, it is recognized and anticipated that changing circumstances of the evolving research program will necessitate revisions. The parties agree to modify this memorandum to reflect such required adjustments. Actual contractual obligations will be set forth in separate documents. The experimenters propsoe to test their prototype 'SciBat-768' detector in the MI-12 building for 3 months (February-April) in Spring 2012. The major goal of this effort is to measure or limit the flux of beam-induced neutrons in a far-off-axis (> 45{sup o}) location of the Booster Neutrino Beamline (BNB). This flux is of interest for a proposed coherent neutral-current neutrino-argon elastic scattering experiment. A second goal is to collect more test data for the SciBath-768 to enable better understanding and calibration of the device. The SciBath-768 detector successfully ran for 3 months in the MINOS Underground Area in Fall 2011 as testbeam experiment T-1014 and is currently running above ground in the MINOS service building. For the run proposed here, the experiments are requesting: space in MI-12 in which to run the SciBath detector during February-April 2012 while the BNB is operating; technical support to help with moving the equipment on site; access to power, internet, and accelerator signals; and a small office space from which to run and monitor the experiment.

  1. EERE Publication and Product Library

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Mail Requests You have not requested any products. You can request that products and publications be mailed to you by clicking on the "Request by Mail" link in the publication...

  2. Public Law 104-134

    Energy Saver

    Public Law 104-134 Debt Collection Improvement Act of 1996 (Public Law 104-134) Updated April 30, 1999 The President has signed into law historic legislation having a major impact ...

  3. MiR-520b suppresses proliferation of hepatoma cells through targeting ten-eleven translocation 1 (TET1) mRNA

    SciTech Connect

    Zhang, Weiying; Lu, Zhanping; Gao, Yuen; Ye, Lihong; Song, Tianqiang; Zhang, Xiaodong

    2015-05-08

    Accumulating evidence indicates that microRNAs are able to act as oncogenes or tumor suppressor genes in human cancer. We previously reported that miR-520b was down-regulated in hepatocellular carcinoma (HCC) and its deregulation was involved in hepatocarcinogenesis. In the present study, we report that miR-520b suppresses cell proliferation in HCC through targeting the ten-eleven translocation 1 (TET1) mRNA. Notably, we identified that miR-520b was able to target 3′-untranslated region (3′UTR) of TET1 mRNA by luciferase reporter gene assays. Then, we revealed that miR-520b was able to reduce the expression of TET1 at the levels of mRNA and protein using reverse transcription-polymerase chain reaction and Western blotting analysis. In terms of function, 5-ethynyl-2-deoxyuridine (EdU) incorporation and colony formation assays demonstrated that the forced miR-520b expression remarkably inhibited proliferation of hepatoma cells, but TET1 overexpression could rescue the inhibition of cell proliferation mediated by miR-520b. Furthermore, anti-miR-520b enhanced proliferation of hepatoma cells, whereas silencing of TET1 abolished anti-miR-520b-induced acceleration of cell proliferation. Then, we validated that the expression levels of miR-520b were negatively related to those of TET1 mRNA in clinical HCC tissues. Thus, we conclude that miR-520b depresses proliferation of liver cancer cells through targeting 3′UTR of TET1 mRNA. Our finding provides new insights into the mechanism of hepatocarcinogenesis. - Highlights: • TET1 is a novel target gene of miR-520b. • TET1 is upregulated in clinical HCC tissues. • MiR-520b is negatively correlated with TET1 in clinical HCC tissues. • MiR-520b depresses the proliferation of HCC cells through targeting TET1 mRNA.

  4. NREL: Transmission Grid Integration - Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications Want updates about future transmission grid integration webinars and ... and Transmission Study Flexible Energy Scheduling Tool for Integration of ...

  5. "Protecting Public Health through Biosecurity"

    SciTech Connect

    Seiders, Barbara AB; Campbell, James R.

    2006-03-04

    "Protecting Public Health through Biosecurity" is an article writen for the Tri-City Herald newspaper special Progress Edition.

  6. Sandia National Laboratories: News: Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications Annual Report Environmental Reports Fact Sheets Labs Accomplishments Lab News Partnerships Annual Report Research Magazine HPC Annual Reports Search Sandia Publications Strategic Plan News Publications Reports authored by Sandia National Laboratories can be obtained through the following sources: Office of Scientific & Technical Information (OSTI): Provides access to Department of Energy research and development reports. National Technical Information Service (NTIS): Official

  7. Publications, 2012 | MIT-Harvard Center for Excitonics

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... organicinorganic bulk heterojunction solar cells," Silvija Gradecak, From Solid State ... Silvija Gradecak, University of Michigan, Ann Arbor, MI, April 2012. "III-V ...

  8. "Title","Creator/Author","Publication Date","OSTI Identifier...

    Office of Scientific and Technical Information (OSTI)

    of Michigan, Ann Arbor, MI (United States); Mackin, D; Beddar, S MD Anderson Cancer Center, Houston, TX (United States); Zheng, Y Procure Proton Therapy Center,...

  9. 2010 Publications Resulting from the Use of NERSC Resources

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    ... 2.0., submitted to International Symposium on ... and Spectra", ACS Journal Chemical Research in Toxicology, Chem. ... SIAM Conference on Mathematics for Industry (MI09) ...

  10. DOE - NNSA/NFO -- EM Public Involvement

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Public Involvement NNSANFO Language Options U.S. DOENNSA - Nevada Field Office Click to subscribe to NNSS News Public Involvement Public Involvement Outreach Photo An integral ...

  11. DOE - NNSA/NFO -- Public Reading Facility

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Public Reading Facility NNSANFO Language Options U.S. DOENNSA - Nevada Field Office Public Reading Facility Photograph of the Public Reading Facility The U.S. Department of ...

  12. DOE - NNSA/NFO -- Current Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Current Publications NNSANFO Language Options U.S. DOENNSA - Nevada Field Office Following are the current publications for the U.S. Department of Energy. Current Publications ...

  13. Property:PublicationName | Open Energy Information

    OpenEI (Open Energy Information) [EERE & EIA]

    publications, such as journal and periodical publications Retrieved from "http:en.openei.orgwindex.php?titleProperty:PublicationName&oldid5930...

  14. Public Reading Room | Jefferson Lab

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Public Reading Room Welcome to the U.S. Department of Energy Public Reading Room. In the Reading Room, you will find a host of technical and non-technical reports about Jefferson Lab and its operations. These reports include the lab's performance report card, environmental impact studies and more. Paper copies of these documents may be read at Jefferson Lab's Public Reading Area, located in CEBAF Center (Building 12), 12000 Jefferson Ave., Newport News, VA 23606. The reading area is located in

  15. 2016 Publications | Argonne National Laboratory

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications 2016 Publications 2016 Publications Ahmed, Shabbir, Kevin Gallagher, Paul Nelson, Naresh Susarla and Dennis Dees. "BatPaC Model Development." Slide presentation at the 2016 DOE Vehicle Technologies Office Annual Merit Review and Peer Evaluation Meeting, Washington, DC US, June 6, 2016 - June 10, 2016. Ahmed, Shabbir, Paul Nelson and Dennis Dees. "Study of a Dry Room in a Battery Manufacturing Plant using a Process Model." Journal of Power Sources 326 Sep 15,

  16. New research, publications and videos

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Researchers have demonstrated an almost four-fold boost of the carrier multiplication yield with nanoengineered quantum dots. Publications August issue of 1663: Los Alamos Science ...

  17. Public Order and Safety Buildings

    Energy Information Administration (EIA) (indexed site)

    | Activity Subcategories | Energy Use Public Order and Safety Buildings... Volunteer fire stations tend not to be government owned, which probably explains why 33 percent of...

  18. Publications | Concentrating Solar Power | NREL

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    develops publications-including technical reports, journal articles, and conference papers-about its research and development (R&D) activities in concentrating solar power (CSP). ...

  19. OCCUPATIONAL RADIATION EXPOSURE – PUBLICATIONS

    Energy.gov [DOE]

    The Radiation Exposure Monitoring System (REMS) database tracks occupational radiation exposures for all monitored DOE employees, contractors, subcontractors and members of the public.

  20. Public Sector Energy Efficiency Programs

    Energy.gov [DOE]

    The program is available to local, state, and federal governments; public school districts; community colleges; and universities that receive electricity and natural gas distribution service from...

  1. Fuel Cell Technologies Office: Publications

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Fuel Cell Technologies Office EERE Fuel Cell Technologies Office Share this resource Publications Advanced Search Browse by Topic Mail Requests Help Feature featured product...

  2. Public Involvment Plan - Rifle, Colorado

    Office of Legacy Management (LM)

    at the New and Old Rifle, Colorado, Uranium Mill Tailings Sites May 1999 Prepared by ... This Public Involvement Plan is tiered to the Uranium Mill Tailings Remedial Action ...

  3. Publications | netl.doe.gov

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Journal PublicationsPatentsTopical Reports Authors Title Journal (page) Date Tran X. ... Coupled Plasma Mass Spectrometry US DOE Topical Report DOENETL-20161794 201604...

  4. Public Utilities Specialist (Energy Efficiency)

    Energy.gov [DOE]

    This position will serve as a Public Utilities Specialist in the Programs group (PEJC) of the Program Implementation organization. The Program Implementation organization is responsible for the...

  5. New research, publications and videos

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    New research, publications and videos Alumni Link: Opportunities, News and Resources for Former Employees Latest Issue:September 2015 all issues All Issues submit New research, ...

  6. Public Involvement and Communications Committee:

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    purposes only 09.08.15 Excerpt from the HAB Process Manual January 2012 Public Involvement and Communications Committee: Develops Board Advice for the TPA agencies on the...

  7. Public Involvement Committee - Transcribed Flipcharts

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    September 3, 2014 Public Involvement Opportunities * Review of PI materials and agency websites, listservs (use of and purpose of notifications). * CD process - approach to PI...

  8. Interested Parties- WAPA Public Comment

    Energy.gov [DOE]

    Comments Received in Response to Western Area Power Administration's Federal Register Notice Titled 'Notice of Proposed Program and Request for Public Comments.'

  9. The RNA-binding protein PCBP2 facilitates gastric carcinoma growth by targeting miR-34a

    SciTech Connect

    Hu, Cheng-En; Liu, Yong-Chao; Zhang, Hui-Dong; Huang, Guang-Jian

    2014-06-13

    Highlights: • PCBP2 is overexpressed in human gastric cancer. • PCBP2 high expression predicts poor survival. • PCBP2 regulates gastric cancer growth in vitro and in vivo. • PCBP2 regulates gastric cancer apoptosis by targeting miR-34a. - Abstract: Gastric carcinoma is the fourth most common cancer worldwide, with a high rate of death and low 5-year survival rate. However, the mechanism underling gastric cancer is still not fully understood. Here in the present study, we identify the RNA-binding protein PCBP2 as an oncogenic protein in human gastric carcinoma. Our results show that PCBP2 is up-regulated in human gastric cancer tissues compared to adjacent normal tissues, and that high level of PCBP2 predicts poor overall and disease-free survival. Knockdown of PCBP2 in gastric cancer cells inhibits cell proliferation and colony formation in vitro, whereas opposing results are obtained when PCBP2 is overexpressed. Our in vivo subcutaneous xenograft results also show that PCBP2 can critically regulate gastric cancer cell growth. In addition, we find that PCBP2-depletion induces apoptosis in gastric cancer cells via up-regulating expression of pro-apoptotic proteins and down-regulating anti-apoptotic proteins. Mechanically, we identify that miR-34a as a target of PCBP2, and that miR-34a is critically essential for the function of PCBP2. In summary, PCBP2 promotes gastric carcinoma development by regulating the level of miR-34a.

  10. Ginsenoside-Rg{sub 1} induces angiogenesis by the inverse regulation of MET tyrosine kinase receptor expression through miR-23a

    SciTech Connect

    Kwok, Hoi-Hin; Chan, Lai-Sheung; Poon, Po-Ying; Yue, Patrick Ying-Kit; Wong, Ricky Ngok-Shun

    2015-09-15

    Therapeutic angiogenesis has been implicated in ischemic diseases and wound healing. Ginsenoside-Rg{sub 1} (Rg{sub 1}), one of the most abundant active components of ginseng, has been demonstrated as an angiogenesis-stimulating compound in different models. There is increasing evidence implicating microRNAs (miRNAs), a group of non-coding RNAs, as important regulators of angiogenesis, but the role of microRNAs in Rg{sub 1}-induced angiogenesis has not been fully explored. In this report, we found that stimulating endothelial cells with Rg{sub 1} could reduce miR-23a expression. In silico experiments predicted hepatocyte growth factor receptor (MET), a well-established mediator of angiogenesis, as the target of miR-23a. Transfection of the miR-23a precursor or inhibitor oligonucleotides validated the inverse relationship of miR-23a and MET expression. Luciferase reporter assays further confirmed the interaction between miR-23a and the MET mRNA 3′-UTR. Intriguingly, ginsenoside-Rg{sub 1} was found to increase MET protein expression in a time-dependent manner. We further demonstrated that ginsenoside-Rg{sub 1}-induced angiogenic activities were indeed mediated through the down-regulation of miR-23a and subsequent up-regulation of MET protein expression, as confirmed by gain- and loss-of-function angiogenic experiments. In summary, our results demonstrated that ginsenoside-Rg{sub 1} could induce angiogenesis by the inverse regulation of MET tyrosine kinase receptor expression through miR-23a. This study has broadened our understanding of the non-genomic effects of ginsenoside-Rg{sub 1,} and provided molecular evidence that warrant further development of natural compound as novel angiogenesis-promoting therapy. - Highlights: • Therapeutic angiogenesis has been implicated in ischemic diseases and wound healing. • Ginsenoside-Rg{sub 1} (Rg{sub 1}) has been demonstrated as an angiogenesis-stimulating compound. • We found that Rg{sub 1} induces angiogenesis by

  11. Analysis of the hydraulic data from the MI fracture zone at the Grimsel Rock Laboratory, Switzerland

    SciTech Connect

    Davey, A.; Karasaki, K.; Long, J.C.S.; Landsfeld, M.; Mensch, A.; Martel, S.J.

    1989-10-01

    One of the major problems in analyzing flow and transport in fractured rock is that the flow may be largely confined to a poorly connected network of fractures. In order to overcome some of this problem, Lawrence Berkeley Laboratory (LBL) has been developing a new type of fracture hydrology model called an equivalent discontinuum model. In this model the authors represent the discontinuous nature of the problem through flow on a partially filled lattice. A key component in constructing an equivalent discontinuum model from this lattice is removing some of the conductive elements such that the system is partially connected in the same manner as the fracture network. This is done through a statistical inverse technique called simulated annealing. The fracture network model is annealed by continually modifying a base model, or template such that the modified systems behave more and more like the observed system. In order to see how the simulated annealing algorithm works, the authors have developed a series of synthetic real cases. In these cases, the real system is completely known so that the results of annealing to steady state data can be evaluated absolutely. The effect of the starting configuration has been studied by varying the percent of conducting elements in the initial configuration. Results have shown that the final configurations converge to about the same percentage of conducting elements. An example using Nagra field data from the Migration Experiment (MI) at Grimsel Rock Laboratory in Switzerland is also analyzed. 24 refs., 33 figs., 3 tabs.

  12. A Flexible Baseline Design for the Advanced High Temperature Reactor Using Metallic Internals (AHTR-MI)

    SciTech Connect

    Peterson, Per F.; Haihua, Zhao

    2006-07-01

    The Advanced High Temperature Reactor (AHTR) is a novel reactor concept that uses clean liquid fluoride salts as a high temperature primary coolant for conventional graphite matrix, coated particle fuels. The very large volumetric heat capacity and excellent natural circulation heat transfer provided by liquid salts enables the design of high-temperature reactors with passive safety features and thermal powers ranging from 2400 to 4000 MW(t). To make optimal use of existing design information, early AHTR designs were modeled upon the S-PRISM sodium pool-reactor design, but introduced an insulated reactor vessel. Subsequent work has shown that liquid-salt cooled systems share important similarities with pressurized water reactors, which use a closed primary loop. This article discusses the use of a closed primary loop immersed in a separate buffer salt tank, which permits the primary loop components to be fabricated from metallic materials (AHTR-MI). This approach may provide several key advantages over open loop approaches, including very large thermal inertia. (authors)

  13. Publications on maglev technologies

    SciTech Connect

    He, J.L.; Coffey, H.T.; Rote, D.M.; Wang, Z.

    1991-12-01

    Magnetically levitated passenger-transportation vehicles, using attractive and repulsive magnetic forces, are currently in the development or prototype-revenue stages in Japan and Germany. The basic principles of these technologies have been understood for several decades, but their practical applications awaited advances in high-power electronic devices, modern controls, superconducting magnets, and improvements in our transportation infrastructures. A considerable amount of work was devoted to magnetic-levitation (maglev) transportation system in the late 1960s and the 1970s. Detailed development was sustained primarily in Germany and Japan. This listing of publications was begun as the initial phase of a design study for a maglev development facility sponsored by the State of Illinois. The listing has been continually updated under programs sponsored by the Federal Railroad Administration and the US Army Corps of Engineers. In 1991, the National Maglev Initiative issued 27 contracts for the study of technical issues related to maglev and four contracts for the definition of maglev systems. In December 1991, the Intermodal Surface Transportation Efficiency Act was enacted, mandating the development of a US-designed maglev system in a six-year period. This listing is offered as an aid to those working on these projects, to help them locate technical papers on relevant technologies. The design and installation of a maglev transportation system will require the efforts of workers in many disciplines, from electronics to economics to safety. Accordingly, the references have been grouped in 14 different sections to expedite review of the listing. In many case, the references are annotated to indicate the general content of the papers. Abstracts are not available. A list of information services from which the listed documents might be obtained and an author index are provided.

  14. Publications | MIT-Harvard Center for Excitonics

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications Publications, Conference Proceedings, and Presentations Browse by year: 2016 2015 2014 2013 2012 2011 2010 2009

  15. Project Management Publications & Documents | Department of Energy

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications & Documents Project Management Publications & Documents << Return to Directives & Documents | Proceed to Policy & Guidance >> Filter by Source Filter by Topic

  16. Monocyte to macrophage differentiation-associated (MMD) targeted by miR-140-5p regulates tumor growth in non-small cell lung cancer

    SciTech Connect

    Li, Weina; He, Fei

    2014-07-18

    Highlights: • Expression of MMD is increased in lung cancer tissues. • Knockdown of MMD inhibits growth of A549 and LLC cells in vitro and in vivo. • MMD is a direct functional target of miR-140-5p. • MiR-140-5p/MMD axis regulates Erk1/2 signaling. - Abstract: Monocyte to macrophage differentiation-associated (MMD) is identified in macrophages as a gene associated with the differentiation from monocytes to macrophages. Recent microarray analysis for non-small cell lung cancer (NSCLC) suggests that MMD is an important signature associated with relapse and survival among patients with NSCLC. Therefore, we speculate that MMD likely plays a role in lung cancer. In this study, we found that the protein level of MMD was increased in lung cancer compared to benign lung tissues, and knockdown of MMD inhibited the growth of A549 and Lewis lung cancer cells (LLC) in vitro and in vivo. Integrated analysis demonstrated that MMD was a direct functional target of miR-140-5p. Furthermore, we found that miR-140-5p/MMD axis could affect the cell proliferation of lung cancer cells by regulating Erk signaling. Together, our results highlight the significance of miR-140-5p/MMD axis in lung cancer, and miR-140-5p/MMD axis could serve as new molecular targets for the therapy against lung cancer.

  17. Effective Public Participation (DOE, 1998)

    Energy.gov [DOE]

    This paper provides guidance to Department of Energy personnel for involving the public effectively and meaningfully in DOE processes conducted under the National Environmental Policy Act. It was prepared in furtherance of the Secretary of Energy's 1994 Public Participation Policy and Policy on the National Environmental Policy Act.

  18. On-Site Research Publications

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    PUBLICATIONS Research News is a new monthly publication from NETL's Office of Research and Development that focuses on exciting research done at the laboratory. For the latest issues of Research News, click here. eNews Archive Netlognews Archive LABNOTES Archive

  19. Public Participation and Community Relations

    Directives, Delegations, and Other Requirements [Office of Management (MA)]

    2003-05-02

    To ensure that public participation and community outreach are integral and effective parts of DOE activities and that decisions are made with the benefit of significant public perspectives. Cancels DOE P 1210.1. Canceled by DOE N 251.104,

  20. Executive summary of major NuMI lessons learned: a review of relevant meetings of Fermilab's DUSEL Beamline Working Group

    SciTech Connect

    Andrews, Mike; Appel, Jeffrey A.; Bogert, Dixon; Childress, Sam; Cossairt, Don; Griffing, William; Grossman, Nancy; Harding, David; Hylen, Jim; Kuchler, Vic; Laughton, Chris; /Fermilab /Argonne /Brookhaven /LBL, Berkeley

    2009-05-01

    We have gained tremendous experience with the NuMI Project on what was a new level of neutrino beams from a high power proton source. We expect to build on that experience for any new long baseline neutrino beam. In particular, we have learned about some things which have worked well and/or where the experience is fairly directly applicable to the next project (e.g., similar civil construction issues including: tunneling, service buildings, outfitting, and potential claims/legal issues). Some things might be done very differently (e.g., decay pipe, windows, target, beam dump, and precision of power supply control/monitoring). The NuMI experience does lead to identification of critical items for any future such project, and what issues it will be important to address. The DUSEL Beamline Working Group established at Fermilab has been meeting weekly to collect and discuss information from that NuMI experience. This document attempts to assemble much of that information in one place. In this Executive Summary, we group relevant discussion of some of the major issues and lessons learned under seven categories: (1) Differences Between the NuMI Project and Any Next Project; (2) The Process of Starting Up the Project; (3) Decision and Review Processes; (4) ES&H: Environment, Safety, and Health; (5) Local Community Buy-In; (6) Transition from Project Status to Operation; and (7) Some Lessons on Technical Elements. We concentrate here on internal project management issues, including technical areas that require special attention. We cannot ignore, however, two major external management problems that plagued the NuMI project. The first problem was the top-down imposition of an unrealistic combination of scope, cost, and schedule. This situation was partially corrected by a rebaselining. However, the full, desirable scope was never achievable. The second problem was a crippling shortage of resources. Critical early design work could not be done in a timely fashion, leading to

  1. Hepatitis B virus X protein mutant HBxΔ127 promotes proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT

    SciTech Connect

    Liu, Fabao; You, Xiaona; Chi, Xiumei; Wang, Tao; Ye, Lihong; Niu, Junqi; Zhang, Xiaodong

    2014-02-07

    Highlights: • Relative to wild type HBx, HBX mutant HBxΔ127 strongly enhances cell proliferation. • Relative to wild type HBx, HBxΔ127 remarkably up-regulates miR-215 in hepatoma cells. • HBxΔ127-elevated miR-215 promotes cell proliferation via targeting PTPRT mRNA. - Abstract: The mutant of virus is a frequent event. Hepatitis B virus X protein (HBx) plays a vital role in the development of hepatocellular carcinoma (HCC). Therefore, the identification of potent mutant of HBx in hepatocarcinogenesis is significant. Previously, we identified a natural mutant of the HBx gene (termed HBxΔ127). Relative to wild type HBx, HBxΔ127 strongly enhanced cell proliferation and migration in HCC. In this study, we aim to explore the mechanism of HBxΔ127 in promotion of proliferation of hepatoma cells. Our data showed that both wild type HBx and HBxΔ127 could increase the expression of miR-215 in hepatoma HepG2 and H7402 cells. However, HBxΔ127 was able to significantly increase miR-215 expression relative to wild type HBx in the cells. We identified that protein tyrosine phosphatase, receptor type T (PTPRT) was one of the target genes of miR-215 through targeting 3′UTR of PTPRT mRNA. In function, miR-215 was able to promote the proliferation of hepatoma cells. Meanwhile anti-miR-215 could partially abolish the enhancement of cell proliferation mediated by HBxΔ127 in vitro. Knockdown of PTPRT by siRNA could distinctly suppress the decrease of cell proliferation mediated by anti-miR-215 in HepG2-XΔ127/H7402-XΔ127 cells. Moreover, we found that anti-miR-215 remarkably inhibited the tumor growth of hepatoma cells in nude mice. Collectively, relative to wild type HBx, HBxΔ127 strongly enhances proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT. Our finding provides new insights into the mechanism of HBx mutant HBxΔ127 in promotion of proliferation of hepatoma cells.

  2. Publications | Center for Gas Separations

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications help Year Title Authors Citation PDF © 2016 The Center for Gas Separations Relevant to Clean Energy Technologies, an Energy Frontier Research Center Click here to select the number of publications visible per page. Filter publications by title, author, or any other part of the citation data. Click on a column header to sort by that column. Click again to toggle between ascending and descending order. Click on any row to see the abstract and ToC image for that entry. Click here for

  3. Argonne National Laboratory 1985 publications

    SciTech Connect

    Kopta, J.A.; Hale, M.R.

    1987-08-01

    This report is a bibliography of scientific and technical 1985 publications of Argonne National Laboratory. Some are ANL contributions to outside organizations' reports published in 1985. This compilation, prepared by the Technical Information Services Technical Publications Section (TPB), lists all nonrestricted 1985 publications submitted to TPS by Laboratory's Divisions. The report is divided into seven parts: Journal Articles - Listed by first author, ANL Reports - Listed by report number, ANL and non-ANL Unnumbered Reports - Listed by report number, Non-ANL Numbered Reports - Listed by report number, Books and Book Chapters - Listed by first author, Conference Papers - Listed by first author, Complete Author Index.

  4. Argonne Scientific Publications | Argonne National Laboratory

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Argonne Scientific Publications Start a New Search Publications Overview Argonne Research Library Argonne Scientific Publications Argonne Scientific Publications is a portal to publications produced by researchers and scientists at Argonne National Laboratory. You can search for citations to journal articles, conference papers and technical reports produced by the Laboratory since 1991. Search Search publication titles, authors, and abstracts. Recent Publications Alderman, O. L. G.; Liska, M. ;

  5. 6 PUBLIC SCOPING MEETING 7 ...

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    19 20 21 22 23 BRIDGES REPORTING & LEGAL VIDEO Certified Shorthand Reporters 24 1030 ... (509) 735-2400 BRIDGES REPORTING & LEGAL VIDEO (800) 358-2345 1 FORMAL PUBLIC COMMENTS 2 ...

  6. Milwaukee Public Library Goes Solar

    Energy.gov [DOE]

    This photograph features the 132-panel rooftop photovoltaic (PV) system installed by the Milwaukee Public Library. The array was installed during an upgrade to the 120-year-old building’s roof. The...

  7. REEE Solicitation Public Meeting Presentation

    Energy.gov [DOE]

    A copy of a REEE Solicitation Public Meeting Presentation. The presentation provides an overview of the Loan Programs Office mission, support, projects, and reviews the Draft Renewable Energy and Energy Efficient Projects Solicitation.

  8. Public Housing Project Performance Benchmarks

    Energy.gov [DOE]

    Reports five major performance metrics that can be used to benchmark proposed energy service company projects within public housing, disaggregated and reported by major retrofit strategy. Author: U.S. Department of Energy

  9. Reporting Publications Just Got Easier!

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    advantages of the changes are: Report journal articles by copying in the DOI or PubMed number. The system will then automatically download all publication details. No more...

  10. Appendix V Public Involvement Plan

    Office of Legacy Management (LM)

    V Public Involvement Plan Revision No.: 6 February 2008 Federal Facility Agreement and Consent Order (FFACO) FFACO, Appendix V February 2008 i FFACO Public Involvement Plan U.S. Department of Energy National Nuclear Security Administration Nevada Site Office Las Vegas, Nevada U.S. Department of Defense Defense Threat Reduction Agency Detachment 1, Nevada Operations Mercury, Nevada U.S. Department of Energy Office of Legacy Management Grand Junction, Colorado FFACO, Appendix V February 2008 ii

  11. Selected Recent Publications and Presentations

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Publications Selected Recent Publications and Presentations Sort by: Date | Author | Type 2016 Zhaoyi Meng, Alice Koniges, Yun (Helen) He, Samuel Williams, Thorsten Kurth, Brandon Cook, Jack Deslippe, Andrea L. Bertozzi, "OpenMP Parallelization and Optimization of Graph-Based Machine Learning Algorithms", IWOMP 2016, 2016, doi: 10.1007/978-3-319-45550-1_2 Michael A. Purvis, Alexander Schafgans, Daniel J. W. Brown, Igor Fomenkov, Rob Rafac, Josh Brown, Yezheng Tao, Slava Rokitski,

  12. New research, publications and videos

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    New research, publications and videos Alumni Link: Opportunities, News and Resources for Former Employees Latest Issue:September 2015 all issues All Issues » submit New research, publications and videos Other information of interest November 1, 2014 Rocket flight test at the Energetic Materials Research and Testing Center launch site near Socorro, NM. Rocket flight test at the Energetic Materials Research and Testing Center launch site near Socorro, NM. Contact Editor Linda Anderman Email News

  13. NERSC Staff Publications & Presentations

    U.S. Department of Energy (DOE) - all webpages (Extended Search)

    Staff Publications & Presentations NERSC Staff Publications & Presentations Sort by: Date | Author | Type 2016 Andrey Ovsyannikov, Brian Van Straalen, Daniel Graves, David Trebotich, "Porting Chombo-Crunch to next-generation architecture", Bay Area Scientific Computing Day, December 11, 2016, Andrey Ovsyannikov, Melissa Romanus, Brian Van Straalen, Gunther H. Weber, David Trebotich, "Scientific Workflows at DataWarp-Speed: Accelerated Data-Intensive Science using NERSC's

  14. Public Services | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Public Services Public Services Find out more about our work with our National Labs Saving Energy Saves You Money Find out more about how technologies move from the lab to the market For Consumers Homes Energy Efficiency 6 Smart Energy Resolutions for 2016 Appliances & Electronics 4 Ways to Slay Energy Vampires This Halloween Now's your chance to ask Energy Department experts your questions about saving energy. This month, we're answering your questions about vehicle fuel efficiency. | Photo

  15. MITEC Small Business Boot Camp In Michigan | Department of Energy

    Energy Saver

    Michigan MITEC Small Business Boot Camp In Michigan September 14, 2016 9:00AM to 3:00PM EDT Detroit, MI DOE's Clean Energy Manufacturing Initiative (CEMI) is hosting a MITEC Boot Camp in Detroit, Michigan coordinated through the Manufacturing Impacts Through Energy and Commerce (MITEC) program. This boot camp is designed to help small- to medium-sized enterprises (SMEs) in advanced energy sectors access DOE national lab capabilities and assets; learn about DOE programs targeting SMEs including

  16. US public perspectives on security :

    SciTech Connect

    Herron, Kerry Gale; Jenkins-Smith, Hank C.; Silva, Carol L.

    2012-02-01

    We report findings from a national Internet survey and a subset of questions administered by telephone in mid-2011 on public assessments of contemporary and emerging interstate nuclear threats, support for strategic arms control, and preferences for responding to limited nuclear attacks on the United States. Additionally, we analyze public views of the threat of terrorism, including cyber attacks, assessments of progress in the struggle against terrorism, and preferences for responding to an act of radiological terrorism against the United States. Also, we report findings from an Internet survey and a subset of questions administered by telephone among the American public in mid-2011 on US energy and environmental security. Key areas of investigation include public views on energy requirements, preferences for energy sources, energy conservation versus development, energy independence, implications of events at Fukushima, Japan, for US public support of nuclear generation, preferences for managing used nuclear fuel, and trust in nuclear risk assessments from government and other public sources. Where possible, findings from each survey are compared with previous surveys in this series for analyses of trends.

  17. Nuclear power and public acceptance

    SciTech Connect

    Hirschmann, H.

    1989-01-01

    Public acceptance is a decisive factor of growing importance, although economics has been and will remain the most decisive factor in ordering new nuclear capacity. Nuclear energy can make an important contribution toward preventing and reducing the greenhouse effect. Many politicians tend to base their decisions not on facts but rather on so called public opinion and consequently to overreact in particular on environmental issues. The entire debate hinges on public confidence rather than on a lack of information. There is no 100% guarantee that technical facilities will operate completely accident-free. Therefore, standards should be harmonized, plants should be operated safely and consequences of possible accidents should be limited. There needs to be some kind of early information system between countries concerning upcoming issues as a prerequisite for acting instead of reacting, because this is an essential tool in convincing the public that they can have more confidence. Technical information alone does not answer the real questions of the public. Political, technical, and economic matters as well as public opinion are interwoven and cannot be separated from each. Therefore, the exchange of experience gained in all these sectors on an international basis must be improved.

  18. Solar Public Interest Waiver | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Solar Public Interest Waiver Solar Public Interest Waiver solar_decision_8-5-11 (91.95 KB) More Documents & Publications Status of Waivers Issued under the Recovery Act: Public Interest Waivers Amended Solar Public Interest Waiver: August 6, 2010 (Amended September 30, 2010) Nationwide Nonavailability Waiver: September 30, 2010

  19. Bioenergy Key Publications | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) (indexed site)

    Key Publications Bioenergy Key Publications This overview highlights key publications issued by the U.S. Department of Energy's Bioenergy Technologies Office. bioenergy_key_publications.pdf (333.56 KB) More Documents & Publications 2013 Peer Review Presentations-Plenaries Technology Pathway Selection Effort 2015 Peer Review Presentations-Plenaries

  20. Mitsubishi iMiEV: An Electric Mini-Car in NREL's Advanced Technology Vehicle Fleet (Fact Sheet)

    SciTech Connect

    Not Available

    2011-10-01

    This fact sheet highlights the Mitsubishi iMiEV, an electric mini-car in the advanced technology vehicle fleet at the National Renewable Energy Laboratory (NREL). In support of the U.S. Department of Energy's fast-charging research efforts, NREL engineers are conducting charge and discharge performance testing on the vehicle. NREL's advanced technology vehicle fleet features promising technologies to increase efficiency and reduce emissions without sacrificing safety or comfort. The fleet serves as a technology showcase, helping visitors learn about innovative vehicles that are available today or are in development. Vehicles in the fleet are representative of current, advanced, prototype, and emerging technologies.